tocainide has been researched along with lidocaine in 284 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 245 (86.27) | 18.7374 |
| 1990's | 30 (10.56) | 18.2507 |
| 2000's | 7 (2.46) | 29.6817 |
| 2010's | 2 (0.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Byrnes, EW; Feldman, HS; McMaster, PD; Takman, BH; Tenthorey, PA | 1 |
| Byrnes, EW; DiRubio, RL; Feldman, HS; McMaster, PD; Takman, BH; Tenthorey, PA | 1 |
| Bódi, I; Frank, L; Hankovszky, OH; Hideg, K | 1 |
| Feldman, HS; McMaster, PD; Ronfeld, RA; Sandberg, RV; Smith, ER; Tenthorey, PA | 1 |
| Block, AJ; Byrnes, EW; McMaster, PD; Tenthorey, PA | 1 |
| Block, AJ; Byrnes, EW; McMaster, PD; Ronfeld, RA; Tenthorey, PA | 1 |
| Adams, HJ; Kronberg, GH; Takman, BH; Tenthorey, PA | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Coumel, P; Krikler, D; Rosen, MR; Wellens, HJ; Zipes, DP | 1 |
| Rabkin, SW | 1 |
| Almotrefi, AA; Dzimiri, N | 2 |
| Conte-Camerino, D; Fakler, B; Franchini, C; Rüdel, R; Ruppersberg, JP; Spittelmeister, W; Stützel, R; Tortorella, V; Tricarico, D | 1 |
| Arnér, S; Lindblom, U; Meyerson, BA; Molander, C | 1 |
| Gehret, JR; Heaney, LA; Lynch, JJ; Stupienski, RF; Wallace, AA | 1 |
| Annesley, T; vasBinder, E | 1 |
| Bolton, CF; Hahn, AF; Parkes, AW; Stewart, SA | 1 |
| Duker, BG | 1 |
| Bertorini, TE; Puniani, TS | 1 |
| Carr, RA; Foster, RT; Freitag, D; Pasutto, FM | 1 |
| Hammermeister, KE | 1 |
| Gottlieb, SS; Kukin, ML; Medina, N; Packer, M; Yushak, M | 1 |
| Cleveland, R; Estes, NA; Manolis, AS; Payne, D; Rastegar, H; Smith, E | 1 |
| Ahmad, S | 1 |
| Coto, H; Hiromasa, S; Kupersmith, J; Li, ZY; Maldonado, C | 1 |
| Axelson, JE; Kwok, DW; McErlane, KM | 1 |
| Desai, DM; Gal, J; Meyer-Lehnert, S | 1 |
| Adamson, PB; Foreman, RD; Hull, SS; Schwartz, PJ; Stith, RD; Vanoli, E | 1 |
| Axelson, J; Igwemezie, L; Kerr, CR; McErlane, KM; Pillai, G; Price, JD; Vaughan, R | 1 |
| Beijnen, JH; Underberg, WJ; van Gijn, R | 1 |
| Bernton, HF; Feinberg, L; Ferrans, V; Sato, N; Travis, WD | 1 |
| Fakler, B; Rüdel, R; Ruppersberg, JP; Spittelmeister, W | 1 |
| Axelson, JE; Kwok, DW; McErlane, KM; Pillai, G; Vaughan, R | 1 |
| Roden, DM | 2 |
| Hashimoto, K; Ishii, M; Komori, S; Mitsuhashi, H | 1 |
| Annesley, T; Davenport, R; Giacherio, D; Matz, K | 1 |
| Podrid, PJ | 2 |
| Keefe, DL; Miura, D; Somberg, JC | 1 |
| Mahapatra, D; Mahapatra, RK | 1 |
| Sasyniuk, BI; Valois, M | 1 |
| Lüderitz, B; Manz, M; Wagner, WL | 1 |
| Cannon, NJ; Duff, HJ; Sheldon, RS | 1 |
| Cannon, NJ; Duff, HJ; Nies, AS; Sheldon, RS | 1 |
| Block, AJ; Merrill, D; Smith, ER | 1 |
| Allen, JD; Harron, DW; Uprichard, AC | 1 |
| Brinkmeier, H; Jockusch, H; Mehrke, G | 1 |
| Brownstein, SL; Constantin, L; Kienzle, MG; Martins, JB | 1 |
| Schwarz, JR | 1 |
| Graboys, TB; Grossbard, CL; Lown, B; Patt, MV | 1 |
| Wilson, JH | 1 |
| Ambrosioni, E; Boriani, G; Boschi, S; Capucci, A; Frabetti, L; Gubelli, S; Magnani, B; Marchesini, B | 1 |
| Martinez, R; Swerdlow, CD | 1 |
| Celestin, C; Foster, JR; Patterson, JH; Powell, JR; Rice, TL | 1 |
| Grauer, K; Gums, J; Skluth, H | 1 |
| Gibson, SM; Morrill, GB | 1 |
| Barbey, JT; Echt, DS; Kopelman, HA; Murray, KT; Roden, DM; Siddoway, LA; Woosley, RL | 1 |
| Snyder, DW | 1 |
| Böhlen, R; Kingston, WJ; Moxley, RT; Ricker, K | 1 |
| Guerra, C; Harris, SC; Wallace, JE | 1 |
| Betzu, R; Downs, L; Gould, LA; Muller, R; Pradeep, V; Vacek, T | 1 |
| Lampert, S; Lown, B; Podrid, PJ; Ravid, S | 1 |
| Burchiel, KJ; Chabal, C; Russell, LC | 1 |
| Benning, CA; Burke, PA | 1 |
| Kwapiszewski, W; Piranowicz-Chaber, E; Skulski, L | 1 |
| Kwapiszewski, W; Pirianowicz-Chaber, E; Skulski, L | 1 |
| Camacho, LM; Grafe, P; Lehmann-Horn, F; Ricker, K; Rüdel, R | 1 |
| Grigat, G; Schwarz, JR | 1 |
| Somberg, J | 1 |
| Roden, DM; Siddoway, LA; Woosley, RL | 1 |
| Roy, D | 1 |
| Engel, T; Kelliher, GJ; Kowey, P; Wetstein, L | 1 |
| Kapil, RP; Lalonde, RL; Mattern, AL; North, DS | 1 |
| Kulkarni, PS; Mikell, FL; Parcon, JP; Subauste, CS | 1 |
| Henderson, GL; Hyde, DM; Robbins, DL; White, RH | 1 |
| Krácmar, J; Krácmarová, J; Stejskal, Z | 1 |
| Arrowsmith, JB; Bosco, L; Creamer, JI | 1 |
| DeSimone, A; Dunn, JM; Groth, PE | 1 |
| Bertram, K; Füchtbauer, EM; Jockusch, H; Reininghaus, J | 1 |
| Hohnloser, SH; Lange, HW; Lown, B; Podrid, PJ; Raeder, EA | 1 |
| Greenspon, AJ; Volosin, KJ | 1 |
| Covinsky, JO; Forrence, E; Mullen, C | 1 |
| Blum, R; Hession, M; Lampert, S; Lown, B; Podrid, PJ; Stein, J | 1 |
| Garton, JP; Gertz, MA; Jennings, WH | 1 |
| Echt, DS; Roden, DM; Woosley, RL | 1 |
| Jones, CW | 1 |
| Flowers, D; Keefe, DL; Somberg, JC; Torres, V; Williams, S | 1 |
| Hillis, WS; Kelman, AW; Murdoch, G; Pottage, A; Thomson, AH; Whiting, B | 1 |
| Andersson, KE; Wettrell, G | 1 |
| Morganroth, J; Nestico, PF | 4 |
| Huang, SK; Marcus, FI | 1 |
| Hulshof, JH; Vermeij, P | 2 |
| Bleske, BE; Zhanel, GG | 1 |
| Tucker, LE | 1 |
| Roden, DM; Woosley, RL | 1 |
| Streib, EW | 2 |
| Proelss, HF; Townsend, TB | 1 |
| Light, RT; Onrot, J; Robertson, D; Robertson, RM; Tantengco, MV | 1 |
| Kinnaird, AA; Man, RY | 2 |
| Harries-Jones, R | 1 |
| Bernard, R; de Hemptinne, J; Gillet, JM; Lewinson, H; Liebens, I; Renard, M; Shita, A; Waterschoot, P | 1 |
| Smith, PJ | 1 |
| Bansal, AM; Frank, WE; Kugler, JD; Norberg, WJ; Pinsky, WW | 1 |
| Barnfield, C; Kemmenoe, AV | 1 |
| Bauman, JL; Deal, BJ; Gallastegui, JL; Hariman, RJ; Martinez, JJ; Miller, SM; Scagliotti, D | 1 |
| Cameron, JS; Dersham, GH; Han, J; O'Connell, DP | 1 |
| Horowitz, LN; Morganroth, J | 1 |
| Bettini, R; Disertori, M; Furlanello, F; Gramegna, L; Stirpe, E; Vergara, G | 1 |
| Lindblom, U; Lindström, P | 1 |
| Kadin, ME; Soff, GA | 1 |
| Bikadoroff, S | 1 |
| Lenarz, T | 1 |
| Di Biase, M; Favale, S; Rizzon, P; Visani, L | 1 |
| Fisher, JD; Kim, SG; Mercando, AD | 1 |
| Eigenberg, MC | 1 |
| Easley, AR; Mann, DE; Reiter, MJ | 1 |
| Kaplan, RM; Paris, PM; Schuster, MR; Stewart, RD | 1 |
| Boutagy, J; O'Shea, K | 1 |
| Hattori, Y; Ishihara, T; Kodama, I; Kusunoki, T; Toyama, J; Yamada, K | 1 |
| Butler, ML; Esterbrooks, D; Hilleman, DE; Mohiuddin, SM; Mooss, AN; Sketch, MH; Stengel, LA | 1 |
| Dahl, JM; Esterbrooks, D; Hilleman, DE; Mohiuddin, SM; Mooss, AN | 1 |
| Cohen, A | 1 |
| Woosley, RL | 1 |
| Beirne, GJ; Moorthy, AV; Patel, AK; Raehl, CL | 1 |
| Friedman, H; Greenblatt, DJ; Meneilly, GP; Scavone, JM | 1 |
| Sperry, K; Standefer, JC; Wohlenberg, N | 1 |
| Hammill, SC; Kreeger, RW | 1 |
| Linderer, EM; Tippe, A | 1 |
| Duker, G; Reid, JJ | 1 |
| Adhar, GC; Bardy, GH; Clay, D; Greene, HL; Lance, BL; Swerdlow, CD | 1 |
| Jockusch, H; Reininghaus, J; Stuhlfauth, I; Zippel, M | 1 |
| Schönweiler, R | 1 |
| Demarco, T; Finkbeiner, W; Gamsu, G; Golden, JA; Stein, MG | 1 |
| Barbey, JT; Echt, DS; Roden, DM; Thompson, KA; Woosley, RL | 1 |
| Blevins, DD; Ellington, BF; Patel, RM | 1 |
| Hattwick, M; Hobbs, J; Kreider, SD; Lange, WR | 1 |
| Goddard, M; Oliphant, LD | 1 |
| Baedeker, W; Barthel, P; Blömer, H; Goedel-Meinen, L; Hofmann, M; Schmidt, G | 1 |
| Lazarus, M; Li, C; Van Natta, B | 1 |
| Berchtold, MW; Jockusch, H; Kluxen, FW; Schöffl, F | 1 |
| Almgren, O; Axenborg, J; Duker, G | 1 |
| Coulter, DM | 1 |
| Cheesman, M; Ward, DE | 1 |
| Aichele, R; Heller, AH; Paik, H | 1 |
| Hirosawa, K; Kasanuki, H; Onishi, S | 1 |
| Pepper, GA | 1 |
| Clarke, CW; el-Mahdi, EO | 1 |
| Bakshi, M; Branagan, P; Kelly, JG; MacMahon, B; Walsh, MJ | 1 |
| Hoffman, BF | 1 |
| Greenberg, RM; Greenspon, AJ; Volosin, K | 1 |
| Collignon, P; Legrand, V | 1 |
| Cohen, MR | 1 |
| Shea, JJ | 2 |
| Horowitz, LN; Kutalek, SP; Morganroth, J | 1 |
| Kuhn, W; Neuser, D; Przuntek, H; Russ, H; Stasch, JP; Witteler, M | 1 |
| Blayney, AW; Colman, BH; Guy, AM; Phillips, MS | 1 |
| Henriksson, NG; Lyttkens, L; Magnusson, M; Padoan, S; Pyykkö, I; Schalén, L | 1 |
| Horowitz, LN; Morganroth, J; Nestico, PF | 1 |
| Morganroth, J; Oshrain, C; Steele, PP | 1 |
| Pfordt, J | 1 |
| Haass, A; Mielke, U; Schmidt, W; Sen, S | 1 |
| Wästerström, SA | 2 |
| Braun, J; Engelmaier, F; Gessler, U; Gluth, WP; Sörgel, F | 1 |
| Vincent, FM; Vincent, T | 1 |
| Borchard, U; Ewerbeck, S; Hafner, D | 1 |
| Hanyok, JJ | 1 |
| Gupta, RN; Lew, M | 1 |
| Fukuzaki, H; Itoh, S; Kobayashi, K | 1 |
| Gülzow, J; Lenarz, T | 1 |
| Lindblom, U; Wiesenfeld-Hallin, Z | 1 |
| Wiesenfeld-Hallin, Z; Woolf, CJ | 1 |
| Modig, J | 1 |
| Sanna, GP | 1 |
| Almotrefi, AA; Baker, JB | 1 |
| Schmitz, W | 1 |
| Hillis, WS; Whiting, B | 1 |
| Somberg, JC | 1 |
| Doherty, JU; Josephson, ME; Kienzle, MG; Williams, PD; Zygmont, D | 1 |
| Duff, HJ; Oates, JA; Roden, DM; Woosley, RL | 1 |
| Mohiuddin, SM; Ross, WB | 1 |
| Lüderitz, B | 1 |
| Sevick, RJ; Wyse, DG | 1 |
| Courtney, KR | 3 |
| Gintant, GA; Hoffman, BF; Naylor, RE | 1 |
| Schilling, G; Schwartzkopff, B; Simon, H | 1 |
| Alpert, JS; Dalen, JE; Haffajee, CI; Howe, JP; Ockene, IS; Paraskos, JA; Sacks, GM | 1 |
| Campbell, RW; Elton, RA; Goodfellow, RM; Hutton, I; Taylor, E | 1 |
| Hess, DS; Scheinman, MM | 1 |
| Augustin, J; Graffner, C; Hanrath, P; Kuck, KH; Pottage, A; Runge, M; Wiegers, U | 1 |
| Datta, SK; Mandal, SK | 1 |
| McErlane, KM; Pillai, GK | 1 |
| Avery, GS; Brogden, RN; Heel, RC; Holmes, B; Speight, TM | 1 |
| Rosen, MR; Wit, AL | 1 |
| Aberg, G; Aberg, L; Fitzgerald, T; McCollom, K; Moller, R; Ronfeld, R | 1 |
| Erhardt, L; Ericsson, CG; Olsson, G; Rehnqvist, N; Sjögren, A; Svensson, G | 1 |
| Block, PJ; Winkle, RA | 1 |
| Pottage, A | 1 |
| Aronow, WS; Esterbrooks, D; Hee, TT; Hilleman, DE; Mohiuddin, SM; Mooss, AN; Patterson, AJ; Reich, JW; Sketch, MH | 1 |
| Harvengt, C | 1 |
| Böhlen, R; Ricker, K; Rohkamm, R | 1 |
| Gal, J; Johnson, P; Maloney, JD; Mastropaolo, W; Moyer, TP; Sedman, AJ | 1 |
| Akhras, F; Emery, P; Holt, D; Jackson, G; Upward, JW | 1 |
| Endell, W; Oltmanns, D; Pottage, A | 1 |
| Hertzberger, DH; Nauta, IL; Rensing, JB; Ruland, CM | 1 |
| Endell, W; Oltmanns, D; Pottage, T | 1 |
| Colley, DG; Duff, HJ; Maffucci, R; Marney, S; Oates, JA; Primm, RK; Roden, DM; Woosley, RL | 1 |
| Currie, P; Ramsdale, DR | 1 |
| Barrigón, S; Tamargo, J; Tejerina, T | 1 |
| Larsson, B; Lyttkens, L; Wästerström, SA | 1 |
| Harrison, DJ; Wathen, CG | 1 |
| Axelson, JE; Kerr, CR; McErlane, KM; Pillai, GK | 1 |
| Gal, J; Sedman, AJ | 2 |
| Gebhardt, A; Hilpert, P; Schmuderer, R | 1 |
| Antonsson, AM; Gyllenhaal, O; Johansson, L; Kylberg-Hanssen, K; Vessman, J | 1 |
| Rossi, L | 1 |
| Carapetis, RJ; Ilsley, AH; Mather, LE; Runciman, WB; Upton, RN | 1 |
| DePace, NL; Morganroth, J; Nestico, PF | 1 |
| Harrison, DC; Mead, RH | 1 |
| McDevitt, DG | 1 |
| Hugenholtz, PG; Serruys, PW; Vanhaleweyk, G | 1 |
| Camm, AJ | 1 |
| Orning, OM | 1 |
| Hellestrand, KJ | 1 |
| Harley, S; Johnson, J; MacVaugh, H; Morganroth, J; Panidis, IP; Smith, E | 1 |
| Allen-Narker, RA; Barritt, DW; Goodfellow, RM; Jordan, SC; Marshall, AJ; Roberts, CJ | 1 |
| Bettini, R; Dal Forno, P; Disertori, M; Furlanello, F; Gramegna, L; Inama, G; Vergara, G | 1 |
| Davidson, NM; Farquhar, DL | 1 |
| Heger, JJ; Prystowsky, EN; Zipes, DP | 1 |
| Luck, JC; Mann, DE; Pratt, CM; Wyndham, CR | 1 |
| Carr, RK; Higgins, SB; Oates, JA; Reele, SB; Roden, DM; Smith, RF; Woosley, RL | 1 |
| Klein, MD; Levine, PA; Ryan, TJ | 1 |
| Ban, T; Kojima, M; Oshita, S; Sada, H | 1 |
| Alpert, JS; Dalen, JE; Haffajee, CI | 1 |
| Harrison, DC; Mason, JW; Winkle, RA | 1 |
| Cho, YW; Kuemmerle, HP; Singh, BN | 1 |
| Evers, H; Luostarinen, V; Lyytikäinen, MT; Wahlén, A | 1 |
| Flanagan, RJ; Gettings, SD; Holt, DW | 1 |
| Axelson, JE; Venkataramanan, R | 1 |
| Nademanee, K; Singh, BN | 1 |
| Borg, T; Karlström, G; Modig, J; Rikner, L; Sahlstedt, B | 1 |
| Block, AJ; Ronfeld, RA; Wolshin, EM | 1 |
| Lown, B; Podrid, PJ | 1 |
| Witkowska, M | 1 |
| Axelson, JE; McErlane, KM; Pillai, GK | 1 |
| Axelson, JE; Elvin, AT; Lalka, D | 1 |
| Johansson, L; Vessman, J | 1 |
| Abbott, FS; Axelson, JE; Venkataramanan, R | 1 |
| Mouselimis, N; Wester, HA | 1 |
| Braude, AC; Chamberlain, DW; Downar, E; Rebuck, AS | 1 |
| Cathcart, JM | 1 |
| Echt, DS; Griffin, JC; Keefe, DL; Mason, JW; Ross, DL; Swerdlow, CD; Sze, DY; Winkle, RA | 1 |
| Bloedow, DC; Gal, J; Sedman, AJ | 1 |
| Atallah, G; Kirkorian, G; Moleur, P; Touboul, P | 1 |
| Axelson, JE; Chan, KT; Elvin, AT; Gipple, KJ; Lalka, D | 1 |
| Davis, A; Hörmann, K; Schmidt, H; Stasche, N | 1 |
| Luo, L; Wiesenfeld-Hallin, Z | 1 |
| Jarvi, EJ; Loi, CM; Vestal, RE; Wei, X | 1 |
| Katz, J | 1 |
| Hauser, U; Hillebrandt, M; Rudack, C; Wagenmann, M | 1 |
| Dai, R; Friedman, FK; Thummel, KE; Vestal, RE; Wei, X; Zhai, S | 1 |
| Blackburn-Munro, G; Erichsen, HK; Hao, JX; Xu, XJ | 1 |
| Carr, DB; Challapalli, V; Lau, J; McNicol, ED; Tremont-Lukats, IW | 1 |
| Erve, JC | 1 |
42 review(s) available for tocainide and lidocaine
| Article | Year |
|---|---|
Pulmonary fibrosis associated with tocainide: report of a case with literature review.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biopsy; Cardiomegaly; Female; Humans; Lidocaine; Lung; Pulmonary Fibrosis; Time Factors; Tocainide | 1990 |
The role of antiarrhythmic drugs in prevention of sudden cardiac death.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide | 1985 |
The treatment of ventricular rhythm disturbances.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Disopyramide; Electric Countershock; Electric Stimulation; Electrocardiography; Exercise Test; Flecainide; Heart Ventricles; Humans; Lidocaine; Phenytoin; Piperidines; Procainamide; Quinidine; Risk; Tachycardia; Tocainide; United States; Ventricular Fibrillation; Verapamil | 1986 |
Ventricular arrhythmias. An assessment of newer therapeutic agents.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Flecainide; Humans; Lidocaine; Mexiletine; Tocainide; United States | 1989 |
Class IB antiarrhythmic drugs: tocainide, mexiletine, and moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Tocainide | 1989 |
Antiarrhythmic drug therapy. Recent advances and current status.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil | 1985 |
Clinical pharmacology of old and new antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide | 1985 |
Antiarrhythmic drugs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium Channel Blockers; Cell Membrane; Disopyramide; Electrophysiology; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide | 1986 |
Clinical pharmacology of antiarrhythmic agents.
Topics: Adrenergic beta-Antagonists; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Calcium Channel Blockers; Electrophysiology; Encainide; Flecainide; Heart Conduction System; Humans; Lidocaine; Moricizine; Phenothiazines; Piperidines; Quaternary Ammonium Compounds; Sotalol; Tocainide | 1985 |
Effects of congestive heart failure on the pharmacokinetics and pharmacodynamics of antiarrhythmic agents.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Digitalis; Disopyramide; Drug Interactions; Encainide; Flecainide; Half-Life; Heart Failure; Hemodynamics; Humans; Kidney; Kinetics; Lidocaine; Liver; Piperidines; Plants, Medicinal; Plants, Toxic; Potassium; Procainamide; Quinidine; Regional Blood Flow; Tocainide | 1986 |
Cardiovascular drugs. I: Antidysrhythmic drugs.
Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Cardiovascular Agents; Disopyramide; Drug Interactions; Humans; Kinetics; Lidocaine; Mexiletine; Phenytoin; Procainamide; Tocainide; Verapamil | 1986 |
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment.
Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil | 1986 |
Antiarrhythmic drug therapy of ventricular arrhythmias.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil | 1986 |
Drug therapy. Tocainide.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Interactions; Electrocardiography; Half-Life; Humans; Kinetics; Lidocaine; Mental Processes; Tocainide | 1986 |
Antiarrhythmic agents for chronic ventricular arrhythmias.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine; Tocainide | 1987 |
Class 1B agents lidocaine, mexiletine, tocainide, phenytoin.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Phenytoin; Tocainide | 1987 |
New antiarrhythmic drugs: tocainide, mexiletine, flecainide, encainide, and amiodarone.
Topics: Administration, Oral; Amiodarone; Anilides; Anti-Arrhythmia Agents; Drug Interactions; Encainide; Flecainide; Heart Conduction System; Humans; Lidocaine; Mexiletine; Tachycardia; Tocainide | 1987 |
Tocainide and mexiletine. Orally effective lidocaine analogues.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Kinetics; Lidocaine; Mexiletine; Propylamines; Tocainide | 1985 |
Modification of the electrophysiologic matrix by antiarrhythmic drugs.
Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzocaine; Electrophysiology; Heart Conduction System; Heart Rate; Humans; Lidocaine; Time Factors; Tocainide; Ventricular Fibrillation | 1985 |
Tocainide: a new oral antiarrhythmic agent.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Electrocardiography; Hemodynamics; Humans; Injections, Intravenous; Kinetics; Lidocaine; Tocainide | 1985 |
Antiarrhythmic drug therapy (Part 2). Benefits and hazards.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Propafenone; Propiophenones; Tocainide | 1985 |
A review of the uses and limitations of tocainide--a class IB antiarrhythmic agent.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Drug Interactions; Electrocardiography; Electrophysiology; Emergencies; Heart; Heart Ventricles; Hemodynamics; Humans; Lidocaine; Myocardial Contraction; Myocardial Infarction; Tocainide | 1985 |
[Electrophysiological classification of newer antiarrhythmic drugs (author's transl)].
Topics: Action Potentials; Adrenergic beta-Antagonists; Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Quinidine; Sodium; Tocainide | 1980 |
Antiarrhythmic drug therapy for sustained ventricular tachycardia.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bethanidine; Calcium Channel Blockers; Disopyramide; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Encainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Phenytoin; Piperidines; Procainamide; Quinidine; Tachycardia; Tocainide | 1984 |
New antiarrhythmic drugs.
Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half-Life; Humans; Hypertension; Lidocaine; Metoprolol; Nadolol; Nifedipine; Propanolamines; Propranolol; Tocainide; Verapamil | 1983 |
Tocainide. A review of its pharmacological properties and therapeutic efficacy.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Interactions; Electrophysiology; Hemodynamics; Humans; Kinetics; Lidocaine; Tissue Distribution; Tocainide | 1983 |
Electropharmacology of antiarrhythmic drugs.
Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Electric Conductivity; Heart Atria; Heart Ventricles; Humans; Lidocaine; Membrane Potentials; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Procainamide; Propranolol; Purkinje Fibers; Quinidine; Tocainide; Verapamil | 1983 |
Hemodynamic effects of antiarrhythmic drugs.
Topics: Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Bretylium Compounds; Calcium Channel Blockers; Disopyramide; Dose-Response Relationship, Drug; Encainide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Myocardial Contraction; Phenytoin; Piperidines; Procainamide; Quinidine; Tocainide | 1983 |
Clinical profiles of newer class I antiarrhythmic agents--tocainide, mexiletine, encainide, flecainide and lorcainide.
Topics: Administration, Oral; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Dose-Response Relationship, Drug; Electrophysiology; Encainide; Flecainide; Hemodynamics; Humans; Injections, Intravenous; Kinetics; Lidocaine; Mexiletine; Piperidines; Tocainide | 1983 |
Serum tocainide enantiomer concentrations in human subjects.
Topics: Animals; Arrhythmias, Cardiac; Humans; Kinetics; Lidocaine; Tocainide | 1984 |
Therapy with conventional antiarrhythmic drugs for ventricular arrhythmias.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Heart Ventricles; Humans; Lidocaine; Procainamide; Propranolol; Quinidine; Tocainide | 1984 |
Therapy with investigational antiarrhythmic drugs.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Tocainide | 1984 |
Haemodynamic effects of encainide, flecainide, lorcainide and tocainide.
Topics: Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Encainide; Flecainide; Hemodynamics; Humans; Lidocaine; Piperidines; Tocainide | 1984 |
Cardiac electrophysiology of four new antiarrhythmic drugs--encainide, flecainide, lorcainide and tocainide.
Topics: Action Potentials; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Electrocardiography; Electrophysiology; Encainide; Flecainide; Heart; Heart Conduction System; Humans; Lidocaine; Piperidines; Sinoatrial Node; Tocainide | 1984 |
Comparison of the efficacy of newly developed antiarrhythmic drugs in the treatment of ventricular tachyarrhythmias.
Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Coronary Disease; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Piperidines; Tachycardia; Tocainide; Ventricular Fibrillation | 1984 |
New insights into the drug treatment of ventricular arrhythmias.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Disopyramide; Humans; Kinetics; Lidocaine; Procainamide; Propranolol; Quinidine; Tocainide | 1984 |
Medical treatment of tinnitus.
Topics: Amitriptyline; Anti-Arrhythmia Agents; Auditory Pathways; Drug Combinations; Humans; Lidocaine; Pain; Perphenazine; Tinnitus; Tocainide | 1984 |
Investigational antiarrhythmic drugs for the treatment of ventricular rhythm disturbances.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Tocainide | 1984 |
[Clinical pharmacology of anti-arrhythymia agents. II. Lignocaine, mexiletine, tocainide, phenytoin].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Kinetics; Lidocaine; Mexiletine; Tocainide | 1981 |
[New antiarrythmic drugs: mexiletine, tocainide, lorcainide, encainide, flecainide, propafenone, cipralan, sotalol].
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Electrophysiology; Encainide; Flecainide; Hemodynamics; Humans; Imidazoles; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Sotalol; Tocainide | 1982 |
Systemic administration of local anesthetic agents to relieve neuropathic pain.
Topics: Administration, Oral; Anesthetics, Intravenous; Anesthetics, Local; Flecainide; Humans; Lidocaine; Mexiletine; Nervous System Diseases; Pain; Randomized Controlled Trials as Topic; Tocainide | 2005 |
Cyclic metabolites: chemical and biological considerations.
Topics: Biotransformation; Etidocaine; Humans; Lidocaine; Melatonin; Methadone; Mitoxantrone; Oxazoles; Tocainide; Xenobiotics | 2008 |
36 trial(s) available for tocainide and lidocaine
| Article | Year |
|---|---|
Comparative hemodynamic effects of procainamide, tocainide, and encainide in severe chronic heart failure.
Topics: Aged; Anilides; Anti-Arrhythmia Agents; Clinical Trials as Topic; Encainide; Female; Heart Failure; Hemodynamics; Humans; Lidocaine; Male; Procainamide; Random Allocation; Tocainide | 1990 |
Randomized double-blind study of intravenous tocainide versus lidocaine for suppression of ventricular arrhythmias after cardiac surgery.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Coronary Disease; Double-Blind Method; Female; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Postoperative Complications; Randomized Controlled Trials as Topic; Tocainide | 1990 |
Stereoselective pharmacokinetics of tocainide in human uraemic patients and in healthy subjects.
Topics: Adult; Female; Half-Life; Humans; Lidocaine; Male; Metabolic Clearance Rate; Stereoisomerism; Tocainide; Uremia | 1990 |
The role of antiarrhythmic drugs in prevention of sudden cardiac death.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide | 1985 |
Efficacy and safety of oral tocainide in refractory ventricular arrhythmia: a preliminary report on an open label study.
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Central Nervous System Diseases; Clinical Trials as Topic; Drug Eruptions; Electrocardiography; Female; Humans; Lidocaine; Long QT Syndrome; Male; Middle Aged; Tachycardia; Tocainide | 1986 |
[Combination of sotalol with the class I B substances mexiletine or tocainide in complex ventricular extrasystole].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Sotalol; Tocainide | 1987 |
Tocainide and metoprolol: an efficacious therapeutic combination in the treatment of premature ventricular beats.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Humans; Lidocaine; Male; Metoprolol; Middle Aged; Monitoring, Physiologic; Random Allocation; Tocainide | 1989 |
Mexiletine and tocainide: a comparison of antiarrhythmic efficacy, adverse effects, and predictive value of lidocaine testing.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Drug Evaluation; Drug Resistance; Drug Therapy, Combination; Electric Stimulation; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Prospective Studies; Quinidine; Random Allocation; Tocainide | 1989 |
The effect of histamine-2 receptor antagonists on tocainide pharmacokinetics.
Topics: Adult; Anti-Arrhythmia Agents; Cimetidine; Drug Interactions; Female; Half-Life; Histamine H2 Antagonists; Humans; Lidocaine; Male; Middle Aged; Ranitidine; Tocainide | 1988 |
Prophylactic tocainide or lidocaine in acute myocardial infarction.
Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged; Myocardial Infarction; Stereoisomerism; Tocainide | 1986 |
Electrophysiologic testing of tocainide and mexiletine for ventricular tachycardia: assessment of the need to test both drugs.
Topics: Drug Evaluation; Heart Ventricles; Humans; Lidocaine; Mexiletine; Prospective Studies; Tachycardia; Tocainide | 1986 |
The analgesic effect of tocainide in trigeminal neuralgia.
Topics: Adult; Aged; Carbamazepine; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Tocainide; Trigeminal Neuralgia | 1987 |
Treatment of tinnitus with lidocaine and tocainide.
Topics: Administration, Oral; Animals; Clinical Trials as Topic; Double-Blind Method; Evoked Potentials, Auditory; Hearing Loss, Sensorineural; Humans; Infusions, Intravenous; Lidocaine; Rabbits; Random Allocation; Tinnitus; Tocainide | 1986 |
Double-blind randomized comparison of intravenous tocainide versus lidocaine in the treatment of chronic ventricular arrhythmias.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; Male; Random Allocation; Tocainide | 1987 |
[Effect of class I anti-arrhythmia agents on the signal-averaged ECG].
Topics: Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Clinical Trials as Topic; Coronary Disease; Disopyramide; Electrocardiography; Female; Flecainide; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Myocardial Infarction; Random Allocation; Signal Processing, Computer-Assisted; Tachycardia; Tocainide | 1988 |
The value of tocainide in the treatment of tinnitus. A double-blind controlled study.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Clinical Trials as Topic; Double-Blind Method; Drug Eruptions; Humans; Lidocaine; Middle Aged; Random Allocation; Tinnitus; Tocainide | 1985 |
Tocainide for arrhythmias.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Heart Ventricles; Humans; Kinetics; Lidocaine; Tocainide | 1985 |
Tocainide: a new oral antiarrhythmic agent.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Electrocardiography; Hemodynamics; Humans; Injections, Intravenous; Kinetics; Lidocaine; Tocainide | 1985 |
A sequential double blind cross-over trial of tocainide hydrochloride in tinnitus.
Topics: Adult; Aged; Clinical Trials as Topic; Dizziness; Double-Blind Method; Headache; Humans; Lidocaine; Middle Aged; Tinnitus; Tocainide | 1985 |
A review of the uses and limitations of tocainide--a class IB antiarrhythmic agent.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Drug Interactions; Electrocardiography; Electrophysiology; Emergencies; Heart; Heart Ventricles; Hemodynamics; Humans; Lidocaine; Myocardial Contraction; Myocardial Infarction; Tocainide | 1985 |
Comparative efficacy and safety of oral tocainide and quinidine for benign and potentially lethal ventricular arrhythmias.
Topics: Administration, Oral; Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Female; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Monitoring, Physiologic; Quinidine; Random Allocation; Tocainide | 1985 |
Auditory brainstem-evoked response after single-dose injection of lidocaine and tocainide.
Topics: Adult; Audiometry, Evoked Response; Auditory Pathways; Brain Stem; Evoked Potentials, Auditory; Humans; Lidocaine; Reaction Time; Tocainide | 1985 |
[Tinnitus therapy with lidocaine and tocainide].
Topics: Administration, Oral; Auditory Threshold; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Evoked Potentials, Auditory; Humans; Infusions, Parenteral; Lidocaine; Random Allocation; Tinnitus; Tocainide | 1985 |
Selection of an antiarrhythmic drug for a sudden-death-prevention trial.
Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Encainide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Moricizine; Morpholines; Phenothiazines; Piperidines; Tocainide; Verapamil | 1982 |
Comparison of tocainide and prajmalium bitartrate for the treatment of ventricular arrhythmias.
Topics: Adult; Aged; Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Female; Heart Diseases; Humans; Lidocaine; Male; Middle Aged; Prajmaline; Tocainide | 1983 |
Prophylaxis of primary ventricular fibrillation with tocainide in acute myocardial infarction.
Topics: Anti-Arrhythmia Agents; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Myocardial Infarction; Random Allocation; Tocainide; Ventricular Fibrillation | 1983 |
Comparative study of tocainide and lidocaine in patients admitted for suspected acute myocardial infarction.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Female; Humans; Lidocaine; Male; Middle Aged; Myocardial Infarction; Tocainide | 1983 |
[Comparative studies of tocainide and propafenone in the treatment of ventricular arrhythmias].
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Electrocardiography; Female; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Propafenone; Propiophenones; Tocainide | 1984 |
Efficacy and safety of intravenous tocainide compared with intravenous lidocaine for acute ventricular arrhythmias immediately after cardiac surgery.
Topics: Acute Disease; Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Clinical Trials as Topic; Double-Blind Method; Female; Heart Ventricles; Humans; Infusions, Parenteral; Lidocaine; Male; Middle Aged; Postoperative Complications; Random Allocation; Tocainide | 1984 |
Prophylaxis against ventricular arrhythmias in suspected acute myocardial infarction: a comparison of tocainide and disopyramide.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Female; Humans; Lidocaine; Male; Middle Aged; Myocardial Infarction; Tocainide; Ventricular Fibrillation | 1984 |
Accumulation of drugs on inner ear melanin. Therapeutic and ototoxic mechanisms.
Topics: Adult; Anesthetics, Local; Animals; Auditory Threshold; Brain Stem; Clinical Trials as Topic; Double-Blind Method; Ear, Inner; Evoked Potentials, Auditory; Guinea Pigs; Hair Cells, Auditory; Humans; Kanamycin; Lidocaine; Male; Melanins; Microscopy, Electron, Scanning; Rats; Tinnitus; Tocainide | 1984 |
Antiarrhythmic efficacy, pharmacokinetics and clinical safety of tocainide in convalescent myocardial infarction patients.
Topics: Adult; Aged; Anilides; Arrhythmias, Cardiac; Blood Pressure; Clinical Trials as Topic; Coronary Angiography; Electrocardiography; Humans; Lidocaine; Middle Aged; Myocardial Infarction; Placebos; Tocainide | 1980 |
Effects of tocainide, an oral analogue of lidocaine, on thromboembolism after total hip replacement.
Topics: Aged; Drug Evaluation; Female; Hip Prosthesis; Humans; Lidocaine; Male; Middle Aged; Phlebography; Postoperative Complications; Pulmonary Embolism; Thromboembolism; Tocainide | 1981 |
[The effect of anti-arrhythmic drugs on myocardial function (author's transl)].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Depression, Chemical; Disopyramide; Echocardiography; Humans; Lidocaine; Mexiletine; Middle Aged; Myocardial Contraction; Placebos; Propafenone; Propiophenones; Tocainide | 1982 |
Assessment of the value of tocainide hydrochloride in the treatment of tinnitus.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Random Allocation; Tinnitus; Tocainide | 1982 |
[Treatment of tinnitus with lidocaine? A report of clinical experiences].
Topics: Administration, Oral; Anesthetics, Local; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Lidocaine; Tinnitus; Tocainide; Treatment Outcome | 1997 |
209 other study(ies) available for tocainide and lidocaine
| Article | Year |
|---|---|
New antiarrhythmic agents. 2. Amide alkyl alpha-amino xylidides.
Topics: Aniline Compounds; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Chemical Phenomena; Chemistry; Chloroform; Coronary Vessels; Dogs; Mice; Structure-Activity Relationship; Xylenes | 1979 |
New antiarrhythmic agents. 3. Primary beta-amino anilides.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Chloroform; Coronary Vessels; Dogs; Mice | 1979 |
New antiarrhythmic agents. 2,2,5,5-Tetramethyl-3-pyrroline-3-carboxamides and 2,2,5,5-tetramethylpyrrolidine-3-carboxamindes.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Evaluation, Preclinical; Indicators and Reagents; Magnetic Resonance Spectroscopy; Nicotine; Ouabain; Rats; Spectrophotometry, Infrared; Structure-Activity Relationship | 1986 |
New antiarrhythmic agents. 4. 1'-(Aminoalkyl)-1,2,3,4-tetrahydronaphthalene-1-spiro-3'-pyrrolidine-2',5'-dione derivatives.
Topics: Animals; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry; Dogs; Kinetics; Naphthalenes; Pyrrolidinones; Tetrahydronaphthalenes | 1981 |
New antiarrhythmic agents. 5. alpha-Aminoaceto-2,6-xylidides with functionalized amide alkyl substituents.
Topics: Acetanilides; Anesthesia, Spinal; Animals; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry; Female; Lethal Dose 50; Mice; Sheep | 1981 |
New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides.
Topics: Animals; Anti-Arrhythmia Agents; Central Nervous System; Chemical Phenomena; Chemistry; Female; Mice; Structure-Activity Relationship; Toluidines | 1981 |
New antiarrhythmic agents. 7. 2,3-Diaminopropionanilides.
Topics: Anesthetics, Local; Anilides; Animals; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry; Female; Heart Rate; Lethal Dose 50; Mice; Rats | 1981 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
Newer antiarrhythmic drugs.
Topics: Administration, Oral; Adult; Amiodarone; Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Child; Edrophonium; Electrophysiology; Heart Conduction System; Heart Ventricles; Humans; Injections, Intravenous; Lidocaine; Mexiletine; Recurrence; Tachycardia; Tocainide; Verapamil; Wolff-Parkinson-White Syndrome | 1978 |
Effect of antiarrhythmic drugs on choline uptake in cardiac cells in culture.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Chick Embryo; Choline; Dose-Response Relationship, Drug; Encainide; Flecainide; Heart; Lidocaine; Myocardium; Propafenone; Tocainide | 1992 |
Comparative effects of procainamide, tocainide and lorcainide on Na(+)-K(+)-ATPase in guinea pig heart preparations.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Female; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardium; Ouabain; Piperidines; Procainamide; Sodium-Potassium-Exchanging ATPase; Tocainide | 1991 |
Stereoselective interaction of tocainide and its chiral analogs with the sodium channels in human myoballs.
Topics: Humans; Lidocaine; Membrane Potentials; Models, Molecular; Molecular Structure; Muscles; Rhabdomyosarcoma; Sodium Channels; Stereoisomerism; Structure-Activity Relationship; Tocainide; Tumor Cells, Cultured | 1991 |
The effect of modifying potassium concentration on the inhibition of myocardial Na(+)-K(+)-ATPase by two class IB antiarrhythmic drugs: lidocaine and tocainide.
Topics: Animals; Anti-Arrhythmia Agents; Female; Guinea Pigs; In Vitro Techniques; Lidocaine; Male; Myocardium; Potassium; Sodium-Potassium-Exchanging ATPase; Tocainide | 1991 |
Prolonged relief of neuralgia after regional anesthetic blocks. A call for further experimental and systematic clinical studies.
Topics: Adolescent; Adult; Aged; Anesthesia, Local; Animals; Female; Humans; Lidocaine; Male; Middle Aged; Nerve Block; Neuralgia; Pain Measurement; Palliative Care; Rats; Rats, Inbred Strains; Time Factors; Tocainide | 1990 |
Antiarrhythmic actions of tocainide in canine models of previous myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Dogs; Female; Heart Conduction System; Lidocaine; Male; Myocardial Infarction; Tachycardia; Time Factors; Tocainide | 1991 |
Liquid chromatographic analysis of mexiletine in serum, with alternate application to tocainide, procainamide, and N-acetylprocainamide.
Topics: Acecainide; Chromatography, High Pressure Liquid; Humans; Lidocaine; Mexiletine; Procainamide; Tocainide | 1991 |
Neuromyotonia in hereditary motor neuropathy.
Topics: Adolescent; Anti-Arrhythmia Agents; Carbamazepine; Child; Electromyography; Female; Humans; Lidocaine; Male; Muscles; Myotonia Congenita; Myotonic Dystrophy; Neural Conduction; Neuromuscular Diseases; Pedigree; Peripheral Nerves; Peripheral Nervous System Diseases; Phenytoin; Tocainide | 1991 |
Frequency dependent effects of tocainide, quinidine, and flecainide on conduction as reflected in the rise time of the monophasic action potential in the isolated guinea pig heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Flecainide; Guinea Pigs; Heart Conduction System; Heart Ventricles; In Vitro Techniques; Kinetics; Lidocaine; Quinidine; Tocainide | 1991 |
Tocainide therapy in muscle cramps and spasms due to neuromuscular disease.
Topics: Adult; Aged; Aged, 80 and over; Electromyography; Female; Humans; Lidocaine; Male; Middle Aged; Muscle Cramp; Neuromuscular Diseases; Spasm; Tocainide | 1991 |
Stereospecific high-performance liquid chromatographic determination of tocainide.
Topics: Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Cyanates; Humans; Isocyanates; Lidocaine; Male; Naphthalenes; Stereoisomerism; Tocainide | 1991 |
Adverse hemodynamic effects of antiarrhythmic drugs in congestive heart failure.
Topics: Anilides; Anti-Arrhythmia Agents; Encainide; Heart Failure; Hemodynamics; Humans; Lidocaine; Procainamide; Tocainide | 1990 |
Tocainide: interstitial pneumonitis.
Topics: Aged; Anti-Arrhythmia Agents; Drug Hypersensitivity; Humans; Lidocaine; Male; Pulmonary Fibrosis; Tocainide | 1990 |
Selective effects of tocainide in canine acute myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Electrocardiography; Heart Conduction System; Lidocaine; Myocardial Infarction; Tocainide | 1990 |
A gas chromatographic assay for tocainide carbamoyl-O-beta-D-glucuronide:quantitation of the base hydrolyzed product, 3-(2',6'-xylyl)-5-methylhydantoin.
Topics: Adult; Anti-Arrhythmia Agents; Calibration; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Hydantoins; Hydrolysis; Lidocaine; Male; Reproducibility of Results; Sodium Hydroxide; Tocainide | 1990 |
Reversed-phase LC resolutions of chiral antiarrhythmic agents via derivatization with homochiral isothiocyanates.
Topics: Anti-Arrhythmia Agents; Chromatography, Liquid; Flecainide; Humans; Indicators and Reagents; Lidocaine; Male; Mexiletine; Propafenone; Thiocyanates; Tocainide | 1990 |
Tocainide and mortality after myocardial infarction: a prospective study in conscious dogs.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Lidocaine; Myocardial Infarction; Prospective Studies; Retrospective Studies; Survival Rate; Tocainide | 1990 |
Gas chromatographic analysis, with nitrogen detection, of tocainide in plasma.
Topics: Humans; Lidocaine; Nitrogen; Tocainide | 1990 |
Inactivation of human sodium channels and the effect of tocainide.
Topics: Cerebellar Neoplasms; Humans; Lidocaine; Medulloblastoma; Models, Biological; Sodium Channels; Tetrodotoxin; Tocainide; Tumor Cells, Cultured | 1990 |
Preparative high-performance liquid chromatography and preparative thin-layer chromatography isolation of tocainide carbamoyl-O-beta-D-glucuronide: structural characterization by gas chromatography-mass spectrometry and fast atom bombardment-mass spectrom
Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Gas Chromatography-Mass Spectrometry; Glucuronidase; Humans; Hydrolysis; Lidocaine; Methylation; Spectrometry, Mass, Fast Atom Bombardment; Tocainide | 1990 |
Antiarrhythmic drugs. Clinical pharmacology of the old and the new agents.
Topics: Acecainide; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden; Delayed-Action Preparations; Disopyramide; Heart Arrest; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Resuscitation; Tocainide | 1985 |
Canine digitalis arrhythmia as a model for detecting Na-channel blocking antiarrhythmic drugs: a comparative study using other canine arrhythmia models and the new antiarrhythmic drugs, propafenone, tocainide, and SUN 1165.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Dogs; Epinephrine; Female; Ion Channels; Lidocaine; Ligation; Male; Ouabain; Propafenone; Propiophenones; Sodium; Tocainide | 1985 |
A high performance liquid chromatographic assay for tocainide with alternate application for the determination of lidocaine, procainamide, and N-acetylprocainamide.
Topics: Acecainide; Administration, Oral; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Lidocaine; Procainamide; Tocainide | 1986 |
Modification of the frequency- and voltage-dependent effects of quinidine when administered in combination with tocainide in canine Purkinje fibers.
Topics: Action Potentials; Animals; Dogs; Female; Heart Conduction System; Ion Channels; Lidocaine; Male; Purkinje Fibers; Quinidine; Tocainide | 1987 |
A receptor for type I antiarrhythmic drugs associated with rat cardiac sodium channels.
Topics: Animals; Anti-Arrhythmia Agents; Batrachotoxins; Disopyramide; Ion Channels; Lidocaine; Male; Myocardium; Rats; Receptors, Drug; Sodium; Stereoisomerism; Tocainide | 1987 |
Stereospecific interaction of tocainide with the cardiac sodium channel.
Topics: Animals; Anti-Arrhythmia Agents; Batrachotoxins; Heart; In Vitro Techniques; Ion Channels; Lidocaine; Male; Rabbits; Rats; Rats, Inbred Strains; Sodium; Stereoisomerism; Tocainide | 1988 |
Stereoselectivity of tocainide pharmacodynamics in vivo and in vitro.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chloroform; Electrocardiography; Female; Heart Conduction System; In Vitro Techniques; Injections, Subcutaneous; Lidocaine; Mice; Myocardial Contraction; Rabbits; Stereoisomerism; Tocainide | 1988 |
Effects of tocainide enantiomers on experimental arrhythmias produced by programmed electrical stimulation.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Electric Stimulation; Electrocardiography; Female; Lidocaine; Male; Stereoisomerism; Tocainide | 1988 |
The myotonic mouse mutant ADR: electrophysiology of the muscle fiber.
Topics: Action Potentials; Animals; Chlorides; Ion Channels; Lidocaine; Mice; Mice, Neurologic Mutants; Muscle Contraction; Muscles; Myotonia; Phenotype; Tocainide | 1988 |
Possible proarrhythmic effects of tocainide in dilated cardiomyopathy.
Topics: Cardiomyopathy, Dilated; Heart Arrest; Humans; Lidocaine; Male; Middle Aged; Tachycardia; Tocainide | 1988 |
[Membrane currents and action potentials of myelinated nerve fibers and their modification by diphenylhydantoin and tocainide].
Topics: Action Potentials; Animals; In Vitro Techniques; Ion Channels; Lidocaine; Nerve Fibers, Myelinated; Phenytoin; Potassium Channels; Rana esculenta; Rats; Rats, Inbred Strains; Sodium Channels; Tocainide | 1988 |
Combination antiarrhythmic therapy for management of malignant ventricular arrhythmia.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Quinidine; Tachycardia; Tocainide | 1988 |
Breast milk tocainide levels.
Topics: Anti-Arrhythmia Agents; Female; Humans; Lidocaine; Milk, Human; Tocainide | 1988 |
Lidocaine & tocainide & mexiletine.
Topics: Drug Interactions; Humans; Lidocaine; Mexiletine; Tocainide | 1989 |
Influence of rifampin on tocainide pharmacokinetics in humans.
Topics: Adult; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Female; Humans; Lidocaine; Male; Rifampin; Tocainide | 1989 |
Tocainide-induced aplastic anemia.
Topics: Adult; Anemia, Aplastic; Anti-Arrhythmia Agents; Humans; Lidocaine; Male; Tocainide | 1989 |
Potassium uptake in muscle during paramyotonic weakness.
Topics: Adult; Arteries; Cold Temperature; Exercise; Forearm; Humans; Hyperkalemia; Infant; Lidocaine; Male; Muscles; Myotonia; Paralysis; Periodicity; Potassium; Tocainide; Veins | 1989 |
Assay of free and total tocainide by high performance liquid chromatography (HPLC) with ultraviolet (UV) detection.
Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Lidocaine; Spectrophotometry, Ultraviolet; Tocainide | 1989 |
Sinoatrial block due to tocainide.
Topics: Aged; Anti-Arrhythmia Agents; Electrocardiography; Female; Heart Block; Humans; Lidocaine; Sinoatrial Block; Tocainide | 1989 |
Congestive heart failure induced by six of the newer antiarrhythmic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Encainide; Female; Heart Failure; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Moricizine; Phenothiazines; Piperidines; Propafenone; Risk Factors; Stroke Volume; Tocainide | 1989 |
The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Injections, Intravenous; Lidocaine; Male; Mexiletine; Neural Conduction; Neuroma; Rats; Rats, Inbred Strains; Sciatic Nerve; Stress, Mechanical; Tocainide | 1989 |
Tocainide in the cardiac ICU.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Critical Care; Female; Humans; Lidocaine; Male; Middle Aged; Tocainide | 1989 |
[Amino acid derivatives of 2,6 and p-aminobenzoic acid. I. Synthesis of derivatives of 2,6-xylidine and various derivatives of PAB].
Topics: 4-Aminobenzoic Acid; Aniline Compounds; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chemical Phenomena; Chemistry; Drug Evaluation; Humans; Lidocaine; Procainamide; Tocainide | 1989 |
[Amino acid derivatives of 2,6-xylidine and p-aminobenzoic acid. II. Synthesis of derivatives of N-(p-aminobenzoylaminoalkylacyl)-2,6-xylidines and study of their resistance to proteolytic factors].
Topics: Aniline Compounds; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Drug Resistance; Gastric Juice; Humans; Hydrolysis; In Vitro Techniques; Lidocaine; Pancreatin; Pepsin A; Tocainide | 1989 |
Adynamia episodica hereditaria: what causes the weakness?
Topics: Adult; Cold Temperature; Electromyography; Humans; Hydrochlorothiazide; In Vitro Techniques; Lidocaine; Male; Paralyses, Familial Periodic; Potassium; Sodium Channels; Tocainide | 1989 |
Tocainide blocks Na currents by accumulation of inactivated Na channels.
Topics: Animals; Cell Membrane Permeability; Electric Conductivity; Electrophysiology; Lidocaine; Male; Membrane Potentials; Nerve Fibers, Myelinated; Ranidae; Rats; Rats, Inbred Strains; Sodium Channels; Species Specificity; Tocainide | 1988 |
Tocainide-induced pulmonary toxicity.
Topics: Diagnosis, Differential; Female; Humans; Lidocaine; Middle Aged; Pulmonary Fibrosis; Tocainide | 1988 |
Tocainide suppression of immune-complex-mediated dermal inflammation: comparison with prostaglandin E1.
Topics: Alprostadil; Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Arthus Reaction; Dose-Response Relationship, Drug; Female; Immunization, Passive; Lidocaine; Rats; Tocainide; Vasculitis | 1986 |
[UV-spectrophotometry in drug control. 33. New drugs with benzene, pyridine, quinoline and phenanthrene chromophores in the molecule. 6. The effect of substitution and solvents].
Topics: Benzene Derivatives; Chemistry, Pharmaceutical; Clenbuterol; Ipratropium; Lidocaine; Morpholines; Oxolinic Acid; Phenanthrenes; Pyridines; Quinolines; Solvents; Spectrophotometry, Ultraviolet; Tocainide; Tramadol | 1987 |
Severe dermatologic reactions reported after treatment with tocainide.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Dermatitis, Exfoliative; Drug Eruptions; Erythema Multiforme; Female; Humans; Lidocaine; Male; Middle Aged; Product Surveillance, Postmarketing; Stevens-Johnson Syndrome; Stomatitis; Tocainide; United States | 1987 |
Tocainide: a severe adverse reaction.
Topics: Aged; Anti-Arrhythmia Agents; Drug Eruptions; Drug Hypersensitivity; Humans; Lidocaine; Male; Tocainide | 1988 |
The myotonic mouse mutant ADR: physiological and histochemical properties of muscle.
Topics: Adenosine Triphosphatases; Animals; Electromyography; Glycerolphosphate Dehydrogenase; Lidocaine; Mice; Mice, Neurologic Mutants; Muscle Contraction; Muscles; Myotonia; Phenotype; Succinate Dehydrogenase; Tocainide | 1988 |
Short- and long-term therapy with tocainide for malignant ventricular tachyarrhythmias.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Death, Sudden; Female; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Recurrence; Tachycardia; Time Factors; Tocainide; Ventricular Fibrillation | 1986 |
Tocainide: a new drug for ventricular arrhythmias.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Heart; Hemodynamics; Humans; Kinetics; Lidocaine; Tocainide | 1986 |
A seizure induced by concurrent lidocaine-tocainide therapy--is it just a case of additive toxicity?
Topics: Aged; Drug Synergism; Drug Therapy, Combination; Humans; Lidocaine; Male; Seizures; Substance Withdrawal Syndrome; Tocainide | 1986 |
Mexiletine and tocainide: does response to one predict response to the other?
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electric Stimulation; Electrocardiography; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Propylamines; Stroke Volume; Tachycardia; Tocainide; Ventricular Fibrillation | 1986 |
Aplastic anemia due to tocainide.
Topics: Aged; Anemia, Aplastic; Anti-Arrhythmia Agents; Female; Humans; Lidocaine; Tocainide | 1986 |
Mass-spectrometric assay of tocainide in serum.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Lidocaine; Pharmaceutical Preparations; Tocainide | 1986 |
The pharmacokinetics of R- and S-tocainide in patients with acute ventricular arrhythmias.
Topics: Acute Disease; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Humans; Kinetics; Lidocaine; Male; Middle Aged; Stereoisomerism; Time Factors; Tocainide | 1986 |
Dose finding of tocainide in the treatment of tinnitus.
Topics: Administration, Oral; Adult; Aged; Drug Evaluation; Female; Humans; Kinetics; Lidocaine; Male; Middle Aged; Tinnitus; Tocainide; Urticaria | 1986 |
Converting patients from intravenous lidocaine to oral tocainide treatment.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Drug Administration Schedule; Humans; Infusions, Parenteral; Lidocaine; Tocainide | 1986 |
Tocainide-induced granulomatous hepatitis.
Topics: Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Granuloma; Humans; Lidocaine; Male; Middle Aged; Tocainide | 1986 |
Successful treatment with tocainide of recessive generalized congenital myotonia.
Topics: Genes, Recessive; Humans; Lidocaine; Male; Myotonia Congenita; Tocainide | 1986 |
Simultaneous liquid-chromatographic determination of five antiarrhythmic drugs and their major active metabolites in serum.
Topics: Anti-Arrhythmia Agents; Buffers; Chromatography, High Pressure Liquid; Disopyramide; Ethylamines; Heart Diseases; Humans; Hydrogen-Ion Concentration; Lidocaine; Procainamide; Quinidine; Temperature; Tocainide | 1986 |
Orthostatic hypotension: clinical spectrum and approach to treatment.
Topics: Adult; Aged; Amiodarone; Disopyramide; Female; Flecainide; Humans; Hypotension, Orthostatic; Lidocaine; Male; Middle Aged; Piperidines; Procainamide; Quinidine; Sympathomimetics; Tocainide | 1986 |
Electrophysiological effects of tocainide on canine subendocardial Purkinje fibers surviving infarction.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electric Stimulation; Female; Heart; Heart Conduction System; In Vitro Techniques; Kinetics; Lidocaine; Male; Myocardial Infarction; Purkinje Fibers; Tocainide | 1986 |
Tocainide and myotonic dystrophy.
Topics: Humans; Lidocaine; Myotonic Dystrophy; Tocainide | 1986 |
[Hemodynamic repercussions and clinical tolerance of 6 class I anti-arrhythmia agents in acute myocardial infarction].
Topics: Ajmaline; Anti-Arrhythmia Agents; Benzeneacetamides; Fluorenes; Hemodynamics; Lidocaine; Mexiletine; Myocardial Infarction; Piperidines; Tocainide | 1986 |
Measurement of tocainide in serum by capillary gas chromatography.
Topics: Anti-Arrhythmia Agents; Chromatography, Gas; Humans; Lidocaine; Tocainide | 1986 |
Torsade de pointes: successful acute control by lidocaine and chronic control by tocainide in two patients--one each with acquired long QT and the congenital long QT syndrome.
Topics: Adolescent; Child; Electrocardiography; Humans; Lidocaine; Male; Tachycardia; Time Factors; Tocainide | 1986 |
A sudden death due to tocainide overdose.
Topics: Aged; Death, Sudden; Humans; Lidocaine; Liver; Male; Tocainide | 1986 |
Effects of tocainide on Purkinje fibers from normal and infarcted ventricular tissues.
Topics: Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Conduction System; Lidocaine; Male; Myocardial Infarction; Purkinje Fibers; Tocainide | 1986 |
Second generation antiarrhythmic agents: have we reached antiarrhythmic Nirvana?
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Tocainide | 1987 |
Drug therapy: flecainide and tocainide.
Topics: Aged; Anti-Arrhythmia Agents; Flecainide; Humans; Lidocaine; Tocainide | 1987 |
[Electrophysiologic and clinical study of tocainide, a new class IB drug].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Monitoring, Physiologic; Tocainide | 1986 |
Paramyotonia congenita: successful treatment with tocainide. Clinical and electrophysiologic findings in seven patients.
Topics: Action Potentials; Adult; Exercise Test; Female; Humans; Lidocaine; Male; Myotonia Congenita; Potassium; Temperature; Tocainide | 1987 |
Tocainide-induced reversible agranulocytosis and anemia.
Topics: Aged; Agranulocytosis; Anemia; Anti-Arrhythmia Agents; Erythropoiesis; Humans; Lidocaine; Male; Tocainide | 1987 |
Mental changes associated with tocainide, a new antiarrhythmic.
Topics: Affective Symptoms; Attention; Electroencephalography; Female; Humans; Lidocaine; Middle Aged; Tocainide | 1987 |
Combination of tocainide and quinidine for better tolerance and additive effects in patients with coronary artery disease.
Topics: Aged; Arrhythmias, Cardiac; Coronary Disease; Drug Combinations; Drug Evaluation; Drug Tolerance; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Quinidine; Tocainide | 1987 |
Mexitil and cross-allergenicity.
Topics: Cross Reactions; Humans; Lidocaine; Mexiletine; Tocainide | 1987 |
Efficacy of class Ib (lidocaine-like) antiarrhythmic agents for prevention of sustained ventricular tachycardia secondary to coronary artery disease.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Electrophysiology; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Procainamide; Tachycardia; Tocainide; Ventricular Fibrillation | 1987 |
Effect on the seizure threshold in dogs of tocainide/lidocaine administration.
Topics: Animals; Dogs; Drug Interactions; Female; Lidocaine; Seizures; Tocainide | 1987 |
Liquid-chromatographic determination of tocainide in plasma, with N-acyl derivatives of tocainide as internal standards.
Topics: Anti-Arrhythmia Agents; Chromatography, Liquid; Humans; Lidocaine; Tocainide | 1987 |
Use-dependent blocking action of newly developed lidocaine-analogs on maximum rate of rise of action potentials in guinea pig papillary muscle.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Depression, Chemical; Guinea Pigs; Kinetics; Lidocaine; Mexiletine; Papillary Muscles; Structure-Activity Relationship; Tocainide | 1987 |
Efficacy and tolerance of tocainide during long-term treatment of malignant ventricular arrhythmias.
Topics: Death, Sudden; Female; Follow-Up Studies; Humans; Kinetics; Lidocaine; Male; Middle Aged; Recurrence; Tachycardia; Time Factors; Tocainide; Ventricular Fibrillation | 1987 |
Accidental overdose of tocainide successfully treated.
Topics: Aged; Anti-Arrhythmia Agents; Gastric Lavage; Humans; Intubation, Intratracheal; Lidocaine; Male; Pacemaker, Artificial; Renal Dialysis; Tocainide | 1987 |
Mexiletine and tocainide: a profile of two lidocaine analogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Heart; Humans; In Vitro Techniques; Lidocaine; Mexiletine; Tocainide | 1987 |
Tocainide pharmacokinetics during continuous ambulatory peritoneal dialysis.
Topics: Half-Life; Humans; Lidocaine; Male; Middle Aged; Osmolar Concentration; Peritoneal Dialysis, Continuous Ambulatory; Tocainide | 1987 |
Gas chromatographic analysis of underivatized tocainide.
Topics: Adult; Anti-Arrhythmia Agents; Chromatography, Gas; Female; Humans; Indicators and Reagents; Lidocaine; Reference Standards; Tocainide | 1987 |
Fatal intoxication by tocainide.
Topics: Adult; Anti-Arrhythmia Agents; Body Fluids; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Female; Gas Chromatography-Mass Spectrometry; Humans; Lidocaine; Suicide; Tocainide | 1987 |
Action of tocainide and mexiletine on the excitation threshold of myelinated nerves.
Topics: Action Potentials; Animals; Electrophysiology; In Vitro Techniques; Lidocaine; Membrane Potentials; Mexiletine; Myelin Sheath; Nerve Fibers; Rana esculenta; Sodium; Tocainide | 1987 |
Recording of monophasic action potentials in the horizontally perfused guinea pig heart. An in vitro method to study drug-induced changes in cardiac electrophysiology.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrodes; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Lidocaine; Male; Perfusion; Quaternary Ammonium Compounds; Signal Processing, Computer-Assisted; Suction; Tocainide | 1987 |
Tocainide for drug-resistant sustained ventricular tachyarrhythmias.
Topics: Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Humans; Lidocaine; Male; Middle Aged; Monitoring, Physiologic; Tachycardia; Tocainide; Ventricular Fibrillation | 1988 |
Reduction of myosin-light-chain phosphorylation and of parvalbumin content in myotonic mouse muscle and its reversal by tocainide.
Topics: Animals; Lidocaine; Mice; Mice, Mutant Strains; Muscle Contraction; Muscle Proteins; Muscles; Myosins; Myotonia; Parvalbumins; Phosphoproteins; Phosphorylation; Tocainide | 1988 |
[Therapy of severe tinnitus. A report of experiences].
Topics: Adult; Aged; Female; Humans; Infusion Pumps; Iontophoresis; Lidocaine; Male; Middle Aged; Tinnitus; Tocainide | 1987 |
Computed tomography: pathologic correlation in lung disease due to tocainide.
Topics: Aged; Anti-Arrhythmia Agents; Biopsy; Female; Humans; Lidocaine; Lung; Pulmonary Fibrosis; Tocainide; Tomography, X-Ray Computed | 1988 |
Tocainide plus quinidine for treatment of ventricular arrhythmias.
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Therapy, Combination; Female; Humans; Lidocaine; Male; Middle Aged; Quinidine; Tocainide | 1988 |
Analysis for aminoethyl-(2,6-dimethylphenyl)carboxamide (tocainide) in serum with a varian advanced automated sample processor and analytichem extraction cassettes.
Topics: Autoanalysis; Humans; Lidocaine; Tocainide | 1988 |
Potential benefit of tocainide in the treatment of ciguatera: report of three cases.
Topics: Adult; Animals; Ciguatera Poisoning; Female; Fishes; Foodborne Diseases; Humans; Lidocaine; Male; Marine Toxins; Middle Aged; Tocainide | 1988 |
Tocainide-associated neutropenia and lupus-like syndrome.
Topics: Agranulocytosis; Humans; Lidocaine; Lupus Erythematosus, Systemic; Male; Middle Aged; Neutropenia; Syndrome; Tocainide | 1988 |
Irreversible interstitial pneumonitis associated with tocainide therapy.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Humans; Lidocaine; Male; Pulmonary Fibrosis; Tocainide | 1988 |
Opposite regulation of the mRNAs for parvalbumin and p19/6.8 in myotonic mouse muscle.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Immunochemistry; Lidocaine; Mice; Mice, Mutant Strains; Muscle Proteins; Muscles; Myotonia; Nucleic Acid Hybridization; Parvalbumins; Protein Biosynthesis; RNA, Messenger; Tocainide | 1988 |
Computerized evaluation of drug-induced changes in guinea-pig epicardial monophasic action potentials.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrodes; Guinea Pigs; Lidocaine; Pericardium; Sotalol; Tocainide | 1988 |
Adverse reactions to tocainide.
Topics: Anti-Arrhythmia Agents; Drug Eruptions; Female; Humans; Lidocaine; Male; Nervous System Diseases; Tocainide | 1985 |
Exacerbation of ventricular tachycardia by tocainide.
Topics: Aged; Electrocardiography; Female; Heart Ventricles; Humans; Hypotension; Lidocaine; Male; Middle Aged; Syncope; Tachycardia; Tocainide | 1985 |
Efficacy of phenytoin, procainamide, and tocainide in murine genetic myotonia.
Topics: Animals; Lidocaine; Mice; Mice, Mutant Strains; Myotonia; Phenytoin; Procainamide; Tocainide | 1985 |
The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of paroxysmal tachycardias.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathies; Chromatography, High Pressure Liquid; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propafenone; Propiophenones; Quinidine; Tachycardia, Paroxysmal; Time Factors; Tocainide; Verapamil | 1985 |
Tocainide (Tonocard) for ventricular arrhythmias.
Topics: Arrhythmias, Cardiac; Humans; Kinetics; Lidocaine; Tocainide | 1985 |
Confusion and paranoia associated with oral tocainide.
Topics: Administration, Oral; Cognition Disorders; Confusion; Female; Humans; Lidocaine; Middle Aged; Paranoid Disorders; Tocainide | 1985 |
Pharmacokinetics and haemodynamic effects of tocainide in patients with acute myocardial infarction complicated by left ventricular failure.
Topics: Aged; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output; Chromatography, Gas; Creatine Kinase; Electrocardiography; Female; Half-Life; Heart Failure; Heart Rate; Hemodynamics; Humans; Kinetics; Lidocaine; Male; Middle Aged; Myocardial Infarction; Stroke Volume; Time Factors; Tocainide | 1985 |
Tocainide associated agranulocytosis.
Topics: Agranulocytosis; Humans; Lidocaine; Male; Middle Aged; Tachycardia; Tocainide | 1985 |
Haemodynamic effects of class I antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Disopyramide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide | 1985 |
Medication errors. Be sure you have the correct dose before administering a drug.
Topics: Arrhythmias, Cardiac; Humans; Lidocaine; Male; Medication Errors; Middle Aged; Nursing Staff, Hospital; Tocainide | 1985 |
Medical treatment of tinnitus.
Topics: Humans; Lidocaine; Tinnitus; Tocainide | 1985 |
Effect of tocainide on the concentrations of norepinephrine dopamine, serotonin and histamine in rat brain and its binding affinity to neuroceptors.
Topics: Animals; Anti-Arrhythmia Agents; Biogenic Amines; Brain; Dopamine; Histamine; Lidocaine; Male; Norepinephrine; Rats; Rats, Inbred Strains; Sensory Receptor Cells; Serotonin; Time Factors; Tocainide | 1985 |
The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness, vertigo, and nystagmus.
Topics: Administration, Topical; Adult; Caloric Tests; Dimenhydrinate; Humans; Infusions, Parenteral; Lidocaine; Motion Sickness; Nausea; Nystagmus, Physiologic; Scopolamine; Tocainide; Vertigo | 1985 |
[Analysis and toxicity of the anti-arrhythmia agent tocainide].
Topics: Adult; Anti-Arrhythmia Agents; Biotransformation; Female; Humans; Lidocaine; Suicide; Tissue Distribution; Tocainide | 1985 |
Antimyotonic therapy with tocainide under ECG control in the myotonic dystrophy of Curschmann-Steinert.
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Lidocaine; Male; Middle Aged; Monitoring, Physiologic; Myotonic Dystrophy; Syndrome; Tocainide | 1985 |
Pharmacokinetics of tocainide in patients with severe renal failure.
Topics: Acute Kidney Injury; Adult; Aged; Creatinine; Female; Half-Life; Hemodynamics; Humans; Kidney Failure, Chronic; Kinetics; Lidocaine; Male; Metabolic Clearance Rate; Middle Aged; Tocainide | 1985 |
Tocainide encephalopathy.
Topics: Aged; Brain Diseases; Humans; Lidocaine; Male; Tocainide | 1985 |
Electrophysiological and antiarrhythmic actions of tocainide in isolated heart preparations of the guinea pig.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electric Stimulation; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Tocainide | 1985 |
Tocainide.
Topics: Anti-Arrhythmia Agents; Humans; Kinetics; Lidocaine; Tocainide | 1985 |
Liquid chromatographic determination of mexiletine and tocainide in human plasma with fluorescence detection after reaction with a modified o-phthalaldehyde reagent.
Topics: Chromatography, Liquid; Drug Stability; Humans; Lidocaine; Mexiletine; o-Phthalaldehyde; Propylamines; Spectrometry, Fluorescence; Tocainide | 1985 |
[Anti-arrhythmia agents (II): Mexiletine, aprindine, tocainide and amiodarone].
Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Humans; Lidocaine; Mexiletine; Tocainide | 1985 |
The effect of systemic tocainide, lidocaine and bupivacaine on nociception in the rat.
Topics: Animals; Bupivacaine; Injections, Intraperitoneal; Lidocaine; Male; Nociceptors; Rats; Rats, Inbred Strains; Time Factors; Tocainide | 1985 |
The systemic administration of local anaesthetics produces a selective depression of C-afferent fibre evoked activity in the spinal cord.
Topics: Animals; Blood Pressure; Depression, Chemical; Electric Stimulation; Evoked Potentials; Heart Rate; Lidocaine; Motor Neurons; Nerve Fibers; Neural Conduction; Neurons, Afferent; Rats; Rats, Inbred Strains; Reflex, Monosynaptic; Spinal Cord; Spinal Nerve Roots; Sural Nerve; Tocainide | 1985 |
The role of lumbar epidural anaesthesia as antithrombotic prophylaxis in total hip replacement.
Topics: Anesthesia, Epidural; Anesthetics, Local; Blood Coagulation; Fibrinolysis; Hemodynamics; Hip Prosthesis; Humans; Lidocaine; Platelet Aggregation; Postoperative Complications; Pulmonary Embolism; Thrombophlebitis; Tocainide | 1985 |
New drugs in the management of ventricular arrhythmias.
Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Drug Interactions; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Propafenone; Propiophenones; Tocainide | 1984 |
The antifibrillatory potency of aprindine, mexiletine, tocainide and lignocaine compared on Langendorff-perfused hearts of rabbits and guinea-pigs.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; In Vitro Techniques; Indenes; Lidocaine; Male; Mexiletine; Ouabain; Perfusion; Propylamines; Rabbits; Tocainide; Ventricular Fibrillation | 1980 |
Antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil | 1983 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil | 1984 |
Antiarrhythmic therapy: new additions and future expectations.
Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Bretylium Tosylate; Disopyramide; Encainide; Humans; Lidocaine; Mexiletine; Tocainide; Verapamil | 1983 |
[Drug therapy of arrhythmia in coronary cardiopathy].
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Cardiac Complexes, Premature; Coronary Disease; Disopyramide; Electrocardiography; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Tachycardia; Tocainide | 1983 |
Long-term management of arrhythmogenic right ventricular dysplasia.
Topics: Adolescent; Cardiomegaly; Cardiomyopathies; Disopyramide; Electrocardiography; Heart Ventricles; Humans; Lidocaine; Male; Tachycardia; Tocainide | 1983 |
Depressant effects of drugs used in myotonia therapy.
Topics: Animals; In Vitro Techniques; Ion Channels; Lidocaine; Mexiletine; Muscle Contraction; Myotonia; Phenytoin; Procainamide; Quinidine; Rana catesbeiana; Tocainide | 1982 |
The influence of molecular form of local anesthetic-type antiarrhythmic agents on reduction of the maximum upstroke velocity of canine cardiac Purkinje fibers.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Benzocaine; Dogs; Heart Conduction System; Ion Channels; Lidocaine; Membrane Potentials; Molecular Conformation; Purkinje Fibers; Sodium; Tocainide | 1983 |
Chronic tocainide therapy for refractory high-grade ventricular arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Drug Administration Schedule; Female; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Tocainide | 1983 |
Pharmacokinetics of tocainide in patients with renal dysfunction and during haemodialysis.
Topics: Aged; Female; Half-Life; Humans; Kidney Diseases; Kinetics; Lidocaine; Male; Middle Aged; Renal Dialysis; Tocainide | 1983 |
Nodal bradycardia induced by tocainide.
Topics: Aged; Bradycardia; Female; Humans; Lidocaine; Tocainide | 1983 |
Gas--liquid chromatographic resolution and assay of tocainide enantiomers using a chiral capillary column and study of their selective disposition in man.
Topics: Adult; Anti-Arrhythmia Agents; Chromatography, Gas; Fluorocarbons; Humans; Lidocaine; Male; Stereoisomerism; Time Factors; Tocainide | 1983 |
Antiarrhythmic effects of tocainide and lidocaine in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Catecholamines; Coronary Disease; Dogs; Heart Rate; Lidocaine; Male; Respiration; Seizures; Tocainide | 1983 |
Tocainide kinetics in congestive heart failure.
Topics: Adult; Aged; Arrhythmias, Cardiac; Drug Evaluation; Female; Heart Failure; Heart Ventricles; Humans; Kinetics; Lidocaine; Male; Middle Aged; Tocainide | 1983 |
Drugs recently released in Belgium.
Topics: Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Arrhythmias, Cardiac; Bacterial Infections; Belgium; Child; Clavulanic Acids; Drug Combinations; Humans; Lidocaine; Tocainide | 1983 |
Different effectiveness of tocainide and hydrochlorothiazide in paramyotonia congenita with hyperkalemic episodic paralysis.
Topics: Adult; Humans; Hydrochlorothiazide; Hyperkalemia; Hypothermia, Induced; Lidocaine; Male; Myotonia Congenita; Paralysis; Physical Exertion; Potassium; Tocainide | 1983 |
The appropriate dosage regime for the transition from intravenous lignocaine to oral tocainide after acute myocardial infarction.
Topics: Administration, Oral; Anti-Arrhythmia Agents; Drug Administration Schedule; Female; Half-Life; Humans; Injections, Intravenous; Lidocaine; Male; Myocardial Infarction; Time Factors; Tocainide | 1983 |
Pharmacokinetics of tocainide in patients with combined hepatic and renal dysfunction.
Topics: Adult; Aged; Creatinine; Half-Life; Humans; Infusions, Parenteral; Kidney Diseases; Kinetics; Lidocaine; Liver Cirrhosis; Male; Middle Aged; Tocainide | 1983 |
Heart failure and hepatitis in a patient taking tocainide.
Topics: Amiodarone; Chemical and Drug Induced Liver Injury; Heart Failure; Humans; Lidocaine; Liver Function Tests; Male; Middle Aged; Tocainide | 1984 |
Alteration of the kinetics of tocainide in combined hepatic and renal insufficiency.
Topics: Anti-Arrhythmia Agents; Humans; Kidney Diseases; Lidocaine; Liver Diseases; Metabolic Clearance Rate; Tocainide | 1983 |
Molecular basis for the antigenicity of lidocaine analogs: tocainide and mexiletine.
Topics: Aged; Anti-Arrhythmia Agents; Antigens; Cross Reactions; Drug Hypersensitivity; Female; Humans; Intradermal Tests; Lidocaine; Mexiletine; Propylamines; Structure-Activity Relationship; Tocainide | 1984 |
Paranoid psychosis induced by tocainide.
Topics: Acute Disease; Anti-Arrhythmia Agents; Humans; Lidocaine; Male; Middle Aged; Paranoid Disorders; Time Factors; Tocainide | 1984 |
Comparison of three beta-amino anilides: IQB-M-81, lidocaine and tocainide, on isolated rat atria.
Topics: Animals; Anti-Arrhythmia Agents; Azepines; Calcium; Heart Atria; Heart Conduction System; Heart Rate; In Vitro Techniques; Isoproterenol; Lidocaine; Myocardial Contraction; Rats; Rats, Inbred Strains; Tocainide | 1983 |
Tocainide and tinnitus. Clinical effect and site of action.
Topics: Animals; Chemical Phenomena; Chemistry; Ear, Inner; Humans; In Vitro Techniques; Lidocaine; Male; Melanins; Rats; Rats, Inbred Strains; Tinnitus; Tocainide | 1984 |
Paranoid psychoses induced by tocainide.
Topics: Aged; Female; Humans; Lidocaine; Paranoid Disorders; Tachycardia; Tocainide | 1984 |
Stereospecific salivary excretion of tocainide enantiomers in man.
Topics: Adult; Chromatography, Gas; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Lidocaine; Male; Saliva; Stereoisomerism; Time Factors; Tocainide | 1984 |
Simultaneous determination of the enantiomers of tocainide in blood plasma using gas-liquid chromatography with electron-capture detection.
Topics: Amphetamine; Chromatography, Gas; Drug Stability; Humans; Lidocaine; Stereoisomerism; Time Factors; Tocainide | 1984 |
The interaction of cycle length with the electrophysiological effect of lidocaine, tocainide and verapamil on canine Purkinje fibers.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Electric Stimulation; Electrophysiology; Female; Heart Conduction System; Lidocaine; Male; Purkinje Fibers; Time Factors; Tocainide; Verapamil | 1984 |
Monitoring of S- and R-tocainide in human plasma after heptafluorobutyrylation, separation on Chirasil-Val and electron-capture detection.
Topics: Acylation; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry; Chromatography, Gas; Fluorocarbons; Humans; Indicators and Reagents; Lidocaine; Stereoisomerism; Tocainide | 1984 |
Nursing care for survivors of sudden cardiac death.
Topics: Adaptation, Psychological; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Heart Arrest; Heart Conduction System; Humans; Lidocaine; Mexiletine; Moricizine; Nursing Assessment; Phenothiazines; Tocainide | 1984 |
A sheep preparation for studying interactions between blood flow and drug disposition. III: Effects of general and spinal anaesthesia on regional blood flow and oxygen tensions.
Topics: Anesthesia, General; Anesthesia, Spinal; Animals; Cefoxitin; Chlormethiazole; Hemodynamics; Lidocaine; Meperidine; Oxygen; Partial Pressure; Pharmaceutical Preparations; Regional Blood Flow; Sheep; Tocainide | 1984 |
Ventricular arrhythmias: current concepts.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Procainamide; Propranolol; Quinidine; Tocainide | 1984 |
The clinical pharmacology of lidocaine congeners--review of encainide, flecainide, lorcainide and tocainide.
Topics: Anilides; Benzeneacetamides; Encainide; Flecainide; Humans; Kinetics; Lidocaine; Piperidines; Tocainide | 1984 |
The use of tocainide, encainide, lorcainide and flecainide for supraventricular arrhythmias.
Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrioventricular Node; Benzeneacetamides; Encainide; Flecainide; Heart Atria; Humans; Lidocaine; Piperidines; Tachycardia; Tocainide; Wolff-Parkinson-White Syndrome | 1984 |
Worsening of arrhythmias during pharmacological treatment.
Topics: Adolescent; Adult; Aged; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Child; Disopyramide; Female; Follow-Up Studies; Humans; Lidocaine; Male; Middle Aged; Nadolol; Piperidines; Propafenone; Propanolamines; Propiophenones; Tocainide | 1984 |
Tinnitus: treatment methods and results.
Topics: Adult; Aged; Anticonvulsants; Benzodiazepines; Cochlear Nerve; Female; Humans; Labyrinth Diseases; Lidocaine; Male; Meniere Disease; Middle Aged; Otosclerosis; Perceptual Masking; Streptomycin; Tinnitus; Tocainide | 1984 |
Possible hepatoxicity of tocainide.
Topics: Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Lidocaine; Liver; Middle Aged; Tocainide | 1984 |
Drug therapy of cardiac arrhythmias.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Biological Availability; Encainide; Half-Life; Humans; Imidazoles; Intestinal Absorption; Kinetics; Lidocaine; Metabolic Clearance Rate; Mexiletine; Propafenone; Propiophenones; Protein Binding; Tachycardia; Tocainide | 1983 |
Tocainide therapy for refractory ventricular arrhythmias.
Topics: Adult; Aged; Anilides; Antibodies, Antinuclear; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Heart Ventricles; Humans; Lidocaine; Male; Middle Aged; Tocainide | 1980 |
Interval-dependent effects of small antiarrhythmic drugs on excitability of guinea-pig myocardium.
Topics: Action Potentials; Alprenolol; Anilides; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Lidocaine; Papillary Muscles; Procainamide; Structure-Activity Relationship; Tocainide | 1980 |
Effects of tocainide and lidocaine on the transmembrane action potentials as related to external potassium and calcium concentrations in guinea-pig papillary muscles.
Topics: Action Potentials; Anilides; Animals; Anti-Arrhythmia Agents; Calcium; Computers; Electric Stimulation; Female; Guinea Pigs; Heart; Kinetics; Lidocaine; Male; Papillary Muscles; Potassium; Tocainide | 1980 |
Tocainide for refractory ventricular arrhythmias of myocardial infarction.
Topics: Adult; Anilides; Antibodies, Antinuclear; Arrhythmias, Cardiac; Female; Heart Failure; Humans; Kinetics; Lidocaine; Male; Myocardial Infarction; Tocainide | 1980 |
Tocainide for drug-resistant ventricular arrhythmias: efficacy, side effects, and lidocaine responsiveness for predicting tocainide success.
Topics: Aged; Anilides; Dose-Response Relationship, Drug; Female; Glomerulonephritis; Humans; Lidocaine; Male; Middle Aged; Tachycardia; Tocainide; Ventricular Fibrillation | 1980 |
Clinical pharmacology of antiarrhythmic drugs: a review and overview, part II.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Humans; Kinetics; Lidocaine; Mexiletine; Phenytoin; Procainamide; Propranolol; Tocainide | 1981 |
Antithrombotic effects of lidocaine and related compounds on laser-induced microvascular injury.
Topics: Anesthetics, Local; Animals; Bupivacaine; Cricetinae; Female; Lasers; Lidocaine; Microcirculation; Thrombosis; Tocainide | 1981 |
Simple method for the measurement of tocainide and lignocaine in blood plasma or serum using gas--liquid chromatography with flame ionisation detection.
Topics: Chromatography, Gas; Humans; Injections, Intravenous; Lidocaine; Tocainide | 1981 |
3-(2,6-Xylyl)-5-methylhydantoin--a metabolite or a metabonate of tocainide in rats.
Topics: Animals; Biotransformation; Drug Stability; Hydantoins; Lidocaine; Male; Rats; Tocainide | 1981 |
Advances in antiarrhythmic therapy. The role of newer antiarrhythmic drugs.
Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Atrioventricular Node; Humans; Lidocaine; Mexiletine; Tocainide; Verapamil | 1982 |
Significance of bicarbonate for antiarrhythmic drug action.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Bicarbonates; Buffers; Heart; HEPES; Lidocaine; Membrane Potentials; Tocainide | 1981 |
On the kinetics and dynamics of tocainide and its metabolites.
Topics: Aged; Animals; Anti-Arrhythmia Agents; Ataxia; Female; Heart Conduction System; Humans; In Vitro Techniques; Kinetics; Lidocaine; Male; Mice; Middle Aged; Models, Biological; Myocardial Infarction; Rabbits; Tocainide | 1982 |
Tocainide for refractory symptomatic ventricular arrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiology; Exercise Test; Female; Follow-Up Studies; Humans; Lidocaine; Male; Middle Aged; Recurrence; Tachycardia; Tocainide; Ventricular Fibrillation | 1982 |
Electron-capture gas-liquid chromatographic determination of tocainide in biological fluids using fused silica capillary columns.
Topics: Animals; Anti-Arrhythmia Agents; Chromatography, Gas; Injections, Intravenous; Lidocaine; Male; Rats; Rats, Inbred Strains; Reference Values; Tocainide | 1982 |
Tocainide protein binding in normal volunteers and trauma patients.
Topics: Anti-Arrhythmia Agents; Humans; Lidocaine; Orosomucoid; Protein Binding; Tocainide; Wounds and Injuries | 1982 |
Determination of tocainide in human plasma by gas chromatography with nitrogen-selective detection after Schiff base formation.
Topics: Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Liquid; Humans; Lidocaine; Reference Values; Schiff Bases; Tocainide | 1982 |
Metabolism of tocainide in the rat.
Topics: Animals; Anti-Arrhythmia Agents; Biotransformation; In Vitro Techniques; Lidocaine; Male; Mass Spectrometry; Methylation; Rats; Rats, Inbred Strains; Tocainide | 1982 |
Tocainide-associated interstitial pneumonitis.
Topics: Aged; Anti-Arrhythmia Agents; Humans; Lidocaine; Male; Pulmonary Fibrosis; Tocainide | 1982 |
Antiarrhythmic drug combinations in the treatment of ventricular tachycardia.
Topics: Aged; Anilides; Anti-Arrhythmia Agents; Blood Pressure; Drug Therapy, Combination; Electrophysiology; Encainide; Female; Humans; Lidocaine; Male; Middle Aged; Procainamide; Propranolol; Quinidine; Tachycardia; Tocainide | 1982 |
Tocainide--an alternative to mexiletine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Mexiletine; Tocainide | 1982 |
Serum binding of tocainide and its enantiomers in human subjects.
Topics: Adult; Anti-Arrhythmia Agents; Blood Proteins; Humans; In Vitro Techniques; Lidocaine; Male; Protein Binding; Stereoisomerism; Tocainide | 1982 |
Pre-column derivatization with fluorescamine and high-performance liquid chromatographic analysis of drugs. Application to tocainide.
Topics: Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Fluorescamine; Humans; Lidocaine; Spectrometry, Fluorescence; Tocainide | 1982 |
Species differences in the urinary excretion of the novel primary amine conjugate: tocainide carbamoyl O-beta-D-glucuronide.
Topics: Animals; Cats; Chlorocebus aethiops; Dogs; Gerbillinae; Guinea Pigs; Lidocaine; Macaca nemestrina; Mice; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Tocainide | 1982 |
[The lidocaine test in tinnitus. Determination of its current status].
Topics: Administration, Oral; Adult; Aged; Auditory Threshold; Chronic Disease; Diazepam; Dose-Response Relationship, Drug; Female; Hearing Tests; Humans; Infusions, Intravenous; Lidocaine; Loudness Perception; Male; Middle Aged; Sick Role; Tinnitus; Tocainide | 1994 |
Effects of intrathecal local anesthetics on spinal excitability and on the development of autotomy.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Decerebrate State; Denervation; Electrophysiology; Female; Injections, Spinal; Lidocaine; Male; Rats; Rats, Sprague-Dawley; Reflex; Sciatic Nerve; Self Mutilation; Spinal Cord; Tocainide | 1995 |
Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity.
Topics: Animals; Anti-Arrhythmia Agents; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Immunoblotting; In Vitro Techniques; Kinetics; Lidocaine; Male; Mexiletine; Microsomes, Liver; Oxidoreductases; Rats; Rats, Sprague-Dawley; Tocainide | 1995 |
Comments on Luo and Wiesenfeld-Hallin (Pain 63 (1995) 173-179)
Topics: Anesthetics, Local; Animals; Denervation; Injections, Spinal; Lidocaine; Postoperative Complications; Preoperative Care; Rats; Sciatic Nerve; Self Mutilation; Tocainide | 1996 |
Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide.
Topics: Anti-Arrhythmia Agents; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Immunoblotting; In Vitro Techniques; Kinetics; Lidocaine; Mexiletine; Models, Molecular; Oxidoreductases; Tocainide | 1999 |
A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.
Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Lamotrigine; Lidocaine; Male; Mexiletine; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Time Factors; Tocainide; Triazines | 2003 |