Page last updated: 2024-08-23

tobramycin and fosfomycin

tobramycin has been researched along with fosfomycin in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.11)18.7374
1990's1 (2.70)18.2507
2000's8 (21.62)29.6817
2010's18 (48.65)24.3611
2020's7 (18.92)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Duewelhenke, N; Eysel, P; Krut, O1
Cheung, A; Götz, F; Herbert, S; Meehl, M1
Amblard, M; Bastide, L; Gualtieri, M; Leonetti, JP; Martinez, J; Pugniere, M; Roquet, F; Villain-Guillot, P1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Cars, O; Löwdin, E; Melhus, A; Tängdén, T1
Blázquez, J; Couce, A; Rodríguez-Rojas, A1
Hamprecht, A; Higgins, PG; Schneiders, T; Seifert, H1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A1
Banerjee, A; Chakrapani, H; Khodade, VS; Lahiri, S; Pulipeta, M; Rangarajan, R; Sharath Chandra, M1
Bardowski, J; Młynarczyk, A; Młynarczyk, G; Osowiecki, H1
Kreft, B; Marre, R; Sack, K; Schulz, E1
Kanno, H; Takahashi, K1
Martinez-Martinez, L; Pascual, A; Perea, EJ; Rodriguez, G; Suárez, AI1
Baker, WR; Barker, LM; Burns, JL; Gurgel, JL; Kenney, TF; MacLeod, DL; Moss, SC; Sutherland, JL1
Blázquez, J; Castañeda-García, A; Couce, A; Gómez, C; Maciá, MD; Oliver, A; Rodríguez-Rojas, A1
Armero, C; Gobernado, M; González, F; López-Quílez, A; Perpiñán, H; Sahuquillo-Arce, JM; Selva, M; Vanaclocha, H1
Geller, DE; Kissner, DG; McColley, SA; McKevitt, M; Montgomery, AB; Moorehead, L; Rolfe, MW; Rosen, JM; Trapnell, BC1
Elborn, JS; McCaughey, G; McKevitt, M; Tunney, MM1
Baker, WR; Barker, LM; Kenney, TF; MacLeod, DL; Sutherland, JL; Therrien, JH; Velayudhan, J1
Anderson, GG; Henig, NR; Kenney, TF; Macleod, DL; O'Toole, GA1
Diamond, P; Elborn, JS; McCaughey, G; McKevitt, M; Tunney, MM1
Elborn, JS; Gilpin, DF; Hoffman, LR; McCaughey, G; McKevitt, M; Schneiders, T; Tunney, MM1
Antoniu, S1
Aktaş, Z; Cantón, R; Díez-Aguilar, M; Morosini, MI; Rodríguez, I; Tedim, AP1
Bergen, PJ; Hirsch, EB; Kirkpatrick, CM; Landersdorfer, CB; McIntosh, MP; Peleg, AY; Walsh, CC1
Avery, LM; Nicolau, DP; Sutherland, CA1
El-Wafa, WMA; Ibrahim, YM1
Bostrom, MP; Carli, AV; Levack, AE; Miller, AO; Turajane, K; Wellman, DS; Yang, X1
Bragantini, D; Carrara, E; Cattaneo, P; Chiamenti, M; Ellis, S; Franceschi, F; Giske, CG; Lodise, T; Menchinelli, G; Piddock, LJV; Righi, E; Sanguinetti, M; Savoldi, A; Scudeller, L; Tacconelli, E1
Abbasi, S; Ataei, B; Hakamifard, A; Homayouni, A; Khorvash, F; Torfeh Esfahani, AA1
Cuesta, T; Genova, R; Laborda, P; Martínez, JL; Sanz-García, F1
Albur, M; Attwood, M; Griffin, P; Macgowan, AP; Noel, AR1
Aktas, Z; Boral, O; Issever, H; Oksuz, L; Oncul, O; Sonmez, N1

Reviews

1 review(s) available for tobramycin and fosfomycin

ArticleYear
Systematic review and meta-analysis of in vitro efficacy of antibiotic combination therapy against carbapenem-resistant Gram-negative bacilli.
    International journal of antimicrobial agents, 2021, Volume: 57, Issue:5

    Topics: Amikacin; Anti-Bacterial Agents; Azabicyclo Compounds; Carbapenems; Ceftazidime; Cephalosporins; Colistin; Drug Combinations; Drug Resistance, Bacterial; Drug Synergism; Drug Therapy, Combination; Fosfomycin; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Imipenem; In Vitro Techniques; Microbial Sensitivity Tests; Polymyxins; Rifampin; Tazobactam; Tobramycin

2021

Trials

2 trial(s) available for tobramycin and fosfomycin

ArticleYear
Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection.
    American journal of respiratory and critical care medicine, 2012, Jan-15, Volume: 185, Issue:2

    Topics: Administration, Inhalation; Adult; Anti-Bacterial Agents; Cough; Cystic Fibrosis; Double-Blind Method; Drug Combinations; Female; Forced Expiratory Volume; Fosfomycin; Humans; Male; Middle Aged; Pseudomonas aeruginosa; Pseudomonas Infections; Respiratory Function Tests; Tobramycin; Treatment Outcome; United States

2012
Comparing inhaled colistin with inhaled fosfomycin/tobramycin as an adjunctive treatment for ventilator-associated pneumonia: An open-label randomized controlled trial.
    The clinical respiratory journal, 2023, Volume: 17, Issue:4

    Topics: Administration, Inhalation; Anti-Bacterial Agents; Colistin; Fosfomycin; Humans; Pneumonia, Bacterial; Pneumonia, Ventilator-Associated; Tobramycin; Treatment Outcome

2023

Other Studies

34 other study(ies) available for tobramycin and fosfomycin

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1

    Topics: Acetamides; Aminoglycosides; Anti-Bacterial Agents; Antimycin A; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Chloramphenicol; Clindamycin; Dose-Response Relationship, Drug; Fluoroquinolones; Glycolysis; HeLa Cells; Humans; Lactic Acid; Linezolid; Macrolides; Mitochondria; Osteoblasts; Oxazolidinones; Rotenone; Tetracyclines; Time Factors

2007
Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Gene Expression Regulation, Bacterial; Humans; Microbial Sensitivity Tests; Polymyxin B; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus; Vancomycin; Vancomycin Resistance

2007
Structure-activity relationships of phenyl-furanyl-rhodanines as inhibitors of RNA polymerase with antibacterial activity on biofilms.
    Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17

    Topics: Animals; Anti-Bacterial Agents; Biofilms; CHO Cells; Cricetinae; Cricetulus; DNA-Directed RNA Polymerases; Furans; Gram-Positive Bacteria; Microbial Sensitivity Tests; Rhodanine; Staphylococcus epidermidis; Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Foreign travel is a major risk factor for colonization with Escherichia coli producing CTX-M-type extended-spectrum beta-lactamases: a prospective study with Swedish volunteers.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; beta-Lactamases; Child; Child, Preschool; Escherichia coli; Escherichia coli Infections; Female; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Sweden; Travel; White People; Young Adult

2010
Frequency of spontaneous resistance to fosfomycin combined with different antibiotics in Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:11

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Fosfomycin; Mutation; Pseudomonas aeruginosa

2010
In vivo selection of a missense mutation in adeR and conversion of the novel blaOXA-164 gene into blaOXA-58 in carbapenem-resistant Acinetobacter baumannii isolates from a hospitalized patient.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Bacterial Proteins; Carbapenems; Drug Resistance, Bacterial; Fatal Outcome; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Reverse Transcriptase Polymerase Chain Reaction

2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:1

    Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics

2011
Bioreductively Activated Reactive Oxygen Species (ROS) Generators as MRSA Inhibitors.
    ACS medicinal chemistry letters, 2014, Jul-10, Volume: 5, Issue:7

    Topics:

2014
Chromosomal localization of resistance to fosfomycin and aminocyclitol antibiotics in hospital strains of Staphylococcus aureus.
    Acta microbiologica Polonica, 1985, Volume: 34, Issue:2

    Topics: Anti-Bacterial Agents; Chromosome Mapping; Chromosomes, Bacterial; DNA Transposable Elements; DNA, Bacterial; Drug Resistance, Microbial; Fosfomycin; Genes, Bacterial; Genetic Markers; Gentamicins; Kanamycin; Plasmids; Staphylococcus aureus; Tobramycin; Transduction, Genetic

1985
[Experimental studies of the nephroprotective effect of fosfomycin].
    Wiener medizinische Wochenschrift (1946), 1987, Feb-28, Volume: 137, Issue:4

    Topics: Acute Kidney Injury; Animals; Cisplatin; Cyclosporins; Dose-Response Relationship, Drug; Female; Fosfomycin; Glycopeptides; Kidney Tubular Necrosis, Acute; Kidney Tubules; Rats; Rats, Inbred Strains; Teicoplanin; Tobramycin

1987
Synergistic activities of combinations of beta-lactams, fosfomycin, and tobramycin against Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 1984, Volume: 26, Issue:5

    Topics: Anti-Bacterial Agents; Cefoperazone; Cefsulodin; Drug Synergism; Fosfomycin; Microbial Sensitivity Tests; Piperacillin; Pseudomonas aeruginosa; Tobramycin

1984
In-vitro activity of antimicrobial agent combinations against multiresistant Acinetobacter baumannii.
    The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:6

    Topics: Acinetobacter; Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Ceftazidime; Cephalosporins; Ciprofloxacin; Drug Resistance, Multiple; Drug Therapy, Combination; Fosfomycin; Imipenem; Microbial Sensitivity Tests; Thienamycins; Tobramycin

1996
Antibacterial activities of a fosfomycin/tobramycin combination: a novel inhaled antibiotic for bronchiectasis.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 64, Issue:4

    Topics: Administration, Inhalation; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bronchiectasis; Colony Count, Microbial; Drug Combinations; Drug Interactions; Fosfomycin; Humans; Lung; Male; Microbial Sensitivity Tests; Microbial Viability; Pneumonia, Bacterial; Rats; Tobramycin; Treatment Outcome

2009
Assessing the emergence of resistance: the absence of biological cost in vivo may compromise fosfomycin treatments for P. aeruginosa infections.
    PloS one, 2010, Apr-15, Volume: 5, Issue:4

    Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Fosfomycin; Genetic Fitness; Imipenem; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

2010
Antimicrobial resistance in more than 100,000 Escherichia coli isolates according to culture site and patient age, gender, and location.
    Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amikacin; Ampicillin; Anti-Bacterial Agents; Cefotaxime; Child; Child, Preschool; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Female; Fosfomycin; Humans; Imipenem; Infant; Male; Middle Aged; Nitrofurantoin; Retrospective Studies; Tobramycin; Young Adult

2011
Antimicrobial activity of fosfomycin and tobramycin in combination against cystic fibrosis pathogens under aerobic and anaerobic conditions.
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2012, Volume: 11, Issue:3

    Topics: Anti-Bacterial Agents; Biofilms; Colony Count, Microbial; Cystic Fibrosis; Drug Combinations; Fosfomycin; Humans; Lung; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microbial Viability; Pseudomonas aeruginosa; Pseudomonas Infections; Staphylococcal Infections; Tobramycin

2012
Fosfomycin enhances the active transport of tobramycin in Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:3

    Topics: Bacterial Proteins; Biological Transport, Active; Carrier Proteins; Drug Synergism; Fosfomycin; Microbial Sensitivity Tests; Mucins; Mutation Rate; Protein Biosynthesis; Pseudomonas aeruginosa; Tobramycin

2012
Eradication of Pseudomonas aeruginosa biofilms on cultured airway cells by a fosfomycin/tobramycin antibiotic combination.
    Pathogens and disease, 2013, Volume: 67, Issue:1

    Topics: Anti-Bacterial Agents; Biofilms; Cell Survival; Cells, Cultured; Colony Count, Microbial; Drug Synergism; Epithelial Cells; Fosfomycin; Humans; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Tobramycin

2013
Resistance development of cystic fibrosis respiratory pathogens when exposed to fosfomycin and tobramycin alone and in combination under aerobic and anaerobic conditions.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Adult; Aerobiosis; Anaerobiosis; Anti-Bacterial Agents; Culture Media; Cystic Fibrosis; Drug Resistance, Bacterial; Drug Synergism; Drug Therapy, Combination; Fosfomycin; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mutation Rate; Pseudomonas aeruginosa; Pseudomonas Infections; Staphylococcal Infections; Tobramycin

2013
Fosfomycin and tobramycin in combination downregulate nitrate reductase genes narG and narH, resulting in increased activity against Pseudomonas aeruginosa under anaerobic conditions.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:11

    Topics: Anaerobiosis; Anti-Bacterial Agents; Bacterial Proteins; Cystic Fibrosis; Drug Combinations; Fosfomycin; Gene Expression Regulation, Bacterial; Humans; Isoenzymes; Lung; Microbial Sensitivity Tests; Nitrate Reductase; Nitrates; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin; Transcription, Genetic

2013
Novel inhaled combined antibiotic formulations in the treatment of Pseudomonas aeruginosa airways infections in cystic fibrosis.
    Expert review of anti-infective therapy, 2015, Volume: 13, Issue:7

    Topics: Administration, Inhalation; Anti-Bacterial Agents; Clinical Trials as Topic; Cystic Fibrosis; Drug Combinations; Fosfomycin; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Respiratory Tract Infections; Tobramycin; Treatment Outcome

2015
Antimicrobial Activity of Fosfomycin-Tobramycin Combination against Pseudomonas aeruginosa Isolates Assessed by Time-Kill Assays and Mutant Prevention Concentrations.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10

    Topics: Anti-Infective Agents; Drug Synergism; Fosfomycin; Microbial Sensitivity Tests; Mutation; Pseudomonas aeruginosa; Tobramycin

2015
Clinically relevant concentrations of fosfomycin combined with polymyxin B, tobramycin or ciprofloxacin enhance bacterial killing of Pseudomonas aeruginosa, but do not suppress the emergence of fosfomycin resistance.
    The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:8

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Interactions; Drug Resistance, Bacterial; Fosfomycin; Humans; Microbial Viability; Polymyxin B; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

2016
Prevalence of in vitro synergistic antibiotic interaction between fosfomycin and nonsusceptible antimicrobials in carbapenem-resistant Pseudomonas aeruginosa.
    Journal of medical microbiology, 2019, Volume: 68, Issue:6

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Azabicyclo Compounds; Carbapenems; Ceftazidime; Cephalosporins; Drug Combinations; Drug Resistance, Bacterial; Drug Synergism; Fosfomycin; Humans; Meropenem; Prevalence; Pseudomonas aeruginosa; Pseudomonas Infections; Tazobactam; Tobramycin; United States

2019
In Vitro Activity of Fosfomycin in Double and Triple Combinations with Imipenem, Ciprofloxacin and Tobramycin Against Multidrug-Resistant Escherichia coli.
    Current microbiology, 2020, Volume: 77, Issue:5

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Multiple, Bacterial; Drug Synergism; Egypt; Fosfomycin; Imipenem; Microbial Sensitivity Tests; Tobramycin; Uropathogenic Escherichia coli

2020
Thermal Stability and in Vitro Elution Kinetics of Alternative Antibiotics in Polymethylmethacrylate (PMMA) Bone Cement.
    The Journal of bone and joint surgery. American volume, 2021, 09-15, Volume: 103, Issue:18

    Topics: Acinetobacter baumannii; Amikacin; Anti-Bacterial Agents; Bone Cements; Drug Stability; Fosfomycin; Kinetics; Meropenem; Microbial Sensitivity Tests; Polymethyl Methacrylate; Prosthesis-Related Infections; Staphylococcus aureus; Tobramycin

2021
Collateral Sensitivity to Fosfomycin of Tobramycin-Resistant Mutants of
    International journal of molecular sciences, 2023, Apr-07, Volume: 24, Issue:8

    Topics: Anti-Bacterial Agents; Drug Collateral Sensitivity; Fosfomycin; Genomics; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Tobramycin

2023
Antibacterial effect of seven days exposure to ceftolozane-tazobactam as monotherapy and in combination with fosfomycin or tobramycin against Pseudomonas aeruginosa with ceftolozane-tazobactam MICs at or above 4 mg/l in an in vitro pharmacokinetic model.
    The Journal of antimicrobial chemotherapy, 2023, 09-05, Volume: 78, Issue:9

    Topics: Anti-Bacterial Agents; Cephalosporins; Fosfomycin; Humans; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Tazobactam; Tobramycin

2023
Efficacy of antibiotic combinations in an experimental sepsis model with Pseudomonas aeruginosa.
    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2023, Volume: 54, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Colistin; Fosfomycin; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Rats; Sepsis; Tobramycin

2023