Page last updated: 2024-08-23

tobramycin and apramycin

tobramycin has been researched along with apramycin in 154 studies

Research

Studies (154)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (14.94)	18.7374
1990's	30 (19.48)	18.2507
2000's	39 (25.32)	29.6817
2010's	35 (22.73)	24.3611
2020's	27 (17.53)	2.80

Authors

Authors	Studies
Cannon, M; Chahwala, SB; Cundliffe, E; Davies, J; Perzynski, S	1
Chaney, MO; Jones, ND; Lam, LK; O'Connor, S	1
Hagaman, EW; Wenkert, E	1
Lashev, LD; Marinkov, TN; Pashov, DA	1
Bennett, M; Hart, CA; Hunter, JE; Shelley, JC; Walton, JR	3
Cundliffe, E; Drocourt, D; Holmes, DJ; Tiraby, G	1
Baltz, RH; Solenberg, PJ	1
Cannon, M; Davies, J; Moazed, D; Noller, HF; Woodcock, J	1
Davies, J; Gomez-Lus, R; Otal, I; Salauze, D	1
Chaslus-Dancla, E; Lafont, JP; Marin, M; Meurisse, M; Pohl, P	1
Hutchinson, CR; Lewandowska-Skarbek, M	1
Castillo, J; Gil, J; Gómez-Lus, ML; Gómez-Lus, R; Gómez-Lus, S; Goñi, P; Madero, P; Rivera, MJ; Rubio, MC	1
Chaslus-Dancla, E; Courvalin, P; Gerbaud, G; Glupcznski, Y; Lafont, JP; Lagorce, M	1
Kyriakis, SC	1
Hafez, HM; Heil, G; Woernle, H	1
Avramova, RS; Kirova, NZ; Leseva, MD; Petkov, AS; Tiagunenko, IuV	1
Lovering, AM; Reeves, DS; White, LO	1
Diakov, L; Pashov, D; Vangelov, S	1
Carlier, C; Chaslus-Dancla, E; Courvalin, P; Lafont, JP; Martel, JL	1
Andreotis, J; Cracknell, VC; Facibeni, G; Owais, E; Pradella, G	1
Ferguson, JL; Rowe, B; Threlfall, EJ; Ward, LR	1
Bradley, DE; Hedges, RW; Shannon, KP; Wray, C	1
Shikha, I	1
Diakov, L; Lashev, L; Pashov, D	1
Bernath, A; Bock, R; Freidlin, PJ; Fromer, A; Hoexter, S; Perlstein, Z; Samberg, Y; Tomer, S; Ziv, G	1
Chaslus-Dancla, E; Lafont, JP	1
Bor, A; Elad, D; Nouws, JF; Soback, S; Ziv, G	1
Burgett, SG; Ingolia, TD; Kaster, KR; Rao, RN	1
Jansen, WA	1
Hedges, RW; Shannon, KP	1
Kozumplík, J; Vlcek, Z	1
Abe, Y; Kawaguchi, H; Naito, T; Nakagawa, S	1
Lashev, LD; Mihailov, R	1
Cunney, RJ; Johnson, AP; Malde, M; Smyth, EG; Woodford, N	1
Young, HK	1
Burns, L; Cooke, EM; George, RC; Johnson, AP; Naidoo, J; Threlfall, EJ; Woodford, N	1
Erickson, BZ; Ross, RF; Tanner, AC	1
Couturier, M; Glupczynski, Y; Lintermans, P; Marin, M; Pohl, P; Van Robaeys, G	1
Fira, D; Topisirovic, L; Vasiljevic, B	1
Glickman, A; Kurtz, B; Risenberg, R; Ziv, G	1
Adamson, M; Lightfoot, D; Mackie, JT; Wishart, M	1
Ebrecht, A; Fries, R; Kobe, A	1
Davies, J; Paget, E	1
Adeola, O; Orban, JI; Patterson, JA; Richards, GN; Sutton, AL	1
Demidchuk, IuA; Fedorenko, VA; Golets, LM	1
Johnson, AP	1
Angus, M; Hopkins, G; Low, JC; Munro, D; Rankin, SC	1
Chattin, SE; Mathew, AG; Upchurch, WG	1
Dua, M; Khanna, M; Lal, R	1
Diarra, MS; Jacques, M; Malouin, F	1
Harvey, SC; Kirst, HA; Li, X; Skolnick, P	1
Ebner, PD; Mathew, AG	1
Martín, M; Mateu, E	1
Beverley, SM; Gehring, AM; Losick, R; Nodwell, JR	1
Gómez-Lus, R	1
Carlson, SA; Frana, TS; Griffith, RW	1
Heller, ED; Leitner, G; Waiman, R	1
Li, TB; Shang, GD; Wang, YG; Xia, HZ	1
Edrington, TS; Farrington, LA; Harvey, RB; Nisbet, DJ	1
Ding, XM; Jiang, WH; Jiao, RS; Tian, YQ; Zhang, N; Zhao, GP	1
Arnett, DB; Cullen, P; Ebner, PD; Mathew, AG	1
Bischoff, KM; Callaway, TR; Edrington, TS; Genovese, KJ; Nisbet, DJ	1
Guo, FC; Kwakkel, RP; Li, HS; Li, WK; Li, XP; Luo, JY; Verstegen, MW; Williams, BA	1
Gunn, GJ; Hillman, K; Hoyle, DV; Knight, HI; Low, JC; Pearce, MC; Shaw, DJ; Woolhouse, ME	1
Consaul, SA; Pavelka, MS	1
Amyes, SG; Pearce, MC; Woolhouse, ME; Yates, CM	1
Du, Y; Li, T; Wang, YG; Xia, H	1
Djeneva, HA; Dyankov, VN; Gurov, BI; Haritova, AM; Lashev, LD; Sotirova, PG	1
Denap, JC; Hergenrother, PJ; Musk, DJ; Thomas, JR	1
Fish, S; Froelich, JM; Han, Q; Hermann, T; Simonsen, KB; Vourloumis, D; Wall, D; Zhao, Q	1
Chen, L; Jiang, W; Lu, Y; Yu, H	1
Clift, RE; Ebner, PD; Garner, KN; Liamthong, S; Mathew, AG; Saxton, AM	1
Feng, YJ; Jiang, ZP; Lin, QY; Wan, JF; Yang, SX; Zhu, WP	1
Blanchard, JS; Magalhaes, ML	1
Fedorka-Cray, PJ; Gray, JT; Harmon, BG; Jones, RD; Kim, LM	1
Kondo, J; Urzhumtsev, A; Westhof, E	1
François, B; Kondo, J; Urzhumtsev, A; Westhof, E	2
Chae, BJ; Hahn, TW; Lee, SL; Lohakare, JD; Moon, WK	1
Emborg, HD; Hammerum, AM; Jakobsen, L; Jensen, VF; Seyfarth, AM	1
Bai, X; Jiang, W; Jiao, R; Jin, Z; Li, X; Tian, W; Wu, H; Xu, M; Yang, Y; Zhao, G; Zhu, Y	1
Amyes, SG; Roe, AJ; Shaw, DJ; Woolhouse, ME; Yates, CM	1
Gunn, GJ; Hall, M; Hunter, EA; Low, JC	1
Baasov, T; Barbieri, CM; Hainrichson, M; Kondo, J; Nudelman, I; Pilch, DS; Shallom-Shezifi, D; Westhof, E	1
Bernacchi, S; Dumas, P; Ennifar, E; Freisz, S; Maechling, C; Marquet, R; Spiess, B	1
Bechthold, A; Fedoryshyn, M; Luzhetskyy, A; Petzke, L; Welle, E	1
He, W; Li, Y; Shao, R; Wang, Y	1
Balenci, D; Bonechi, G; D'Amelio, N; Dziuba, M; Gaggelli, E; Gaggelli, N; Jezowska-Bojczuk, M; Molteni, E; Swiecicki, G; Szczepanik, W; Valensin, G	1
Ding, LJ; Fan, MZ; Zhang, XY	1
Belo, A; Bernardo, F; da Costa, PM; Gonçalves, J	1
Balenci, D; Cellai, L; D'Amelio, N; Gaggelli, E; Gaggelli, N; Molteni, E; Valensin, G	1
Fessler, AT; Kadlec, K; Schwarz, S	1
Choi, MJ; Jung, SC; Kim, AR; Kim, MN; Lim, SK; Nam, HM	1
Fedorenko, V; Luzhetskyy, A; Myronovskyi, M; Welle, E	1
Jang, GC; Jung, SC; Kim, A; Lee, HS; Lim, SK; Nam, HM	1
Fenner, AM; Kerns, RJ	1
Hong, W; Yan, S	1
Akbergenov, R; Böttger, EC; Dubbaka, SR; Duscha, S; Lang, K; Matt, T; Meyer, M; Ng, CL; Perez-Fernandez, D; Ramakrishnan, V; Schacht, J; Sha, SH; Shcherbakov, D; Vasella, A; Xie, J	1
Couto, N; Feßler, AT; Kadlec, K; Pomba, CF; Schwarz, S	1
Aitken, CE; Ehrenberg, M; Johansson, M; Korlach, J; Marshall, RA; Puglisi, EV; Puglisi, JD; Tsai, A; Uemura, S	1
Ciesiołka, J; Gaggelli, E; Gaggelli, N; Górska, A; Jeżowska-Bojczuk, M; Nagaj, J; Stokowa-Sołtys, K; Szczepanik, W; Valensin, G; Wrzesiński, J	1
Garneau-Tsodikova, S; Green, KD; Jennings, BC; Labby, KJ	1
Adir, N; Baasov, T; Jaffe, CL; Kondo, J; Kopelyanskiy, D; Shalev, M	1
Jang, GC; Jung, SC; Kim, AR; Kim, TS; Lee, HS; Lim, SK; Nam, HM	1
Cameron, A; Gaynor, EC	1
Böttger, EC; Crich, D; Duscha, S; Mandhapati, AR; Shcherbakov, D; Vasella, A	1
Böttger, EC; Freihofer, P; Lenaerts, A; Meyer, M; Scherman, M; Teague, J	1
Chen, Q; Zhang, J	1
Combes, S; Gidenne, T; Jacquier, V; Oswald, IP; Rogel-Gaillard, C	1
Hall, RM; Harmer, CJ; Holt, KE	1
Guo, Z; Jin, Y; Li, H; Liang, L; Liu, X; Long, Z; Wei, J; Wu, N; Zhang, Q	1
Hansen, MH; Hendriksen, RS; Herrero-Fresno, A; Nielsen, A; Nielsen, SS; Olsen, JE; Zachariasen, C	1
Benhida, R; Darfeuille, F; Di Giorgio, A; Duca, M; Staedel, C; Tran, TP; Vo, DD	1
Deng, Z; Ding, W; Ji, X; Li, Y; Lv, M; Su, L; Yu, Y; Zhang, C; Zhang, Q; Zhao, J	1
Dasenaki, ME; Michali, CS; Thomaidis, NS	1
Eguchi, T; Kudo, F; Tokumitsu, T	1
Kirby, JE; Smith, KP	1
Kim, KS; Kim, M	2
Dai, C; Tang, S; Velkov, T; Xiao, X; Yang, X; Zhao, T	1
Böttger, EC; Crich, D; Hobbie, SN; Kato, T; Mandhapati, AR; Shcherbakov, D; Vasella, A; Yang, G	1
Aboklaish, AF; Böttger, EC; Cao, S; Crich, D; Ercan, O; Hobbie, SN; Hughes, D; Huseby, DL; Juhas, M; Petersson, A; Polikanov, YS; Rominski, A; Teo, J; Tyrrell, JM; Walsh, TR; Widlake, E	1
Berg, G; Kang, AD; Kirby, JE; Riedel, S; Smith, KP; Vijayakumar, D	1
Čusak, A; Durán-Alonso, MB; Fernández-Martínez, M; Fujs, Š; García-Mateo, N; Ishikawa, M; Knipper, M; Kosec, G; López-Hernández, I; Löwenheim, H; Martínez-Martínez, L; Müller, M; Petković, H; Rüttiger, L; Schimmang, T; Singer, W	1
Fazaeli, R; Naser, I; Saadi, Z; Vafajoo, L	1
Badr, IHA; Mabrouk, MM; Noureldin, HAM; Saad, AHK	1
Chen, C; Hu, W; Li, J; Li, R; Lu, X; Muhammad, I; Tian, E; Wu, Z	1
Böttger, EC; Crich, D; Fang, QJ; Gysin, M; Haldimann, K; Hobbie, SN; Osinnii, I; Quirke, JCK; Rajasekaran, P; Sarpe, VA; Schacht, J; Sha, SH; Shcherbakov, D; Sonousi, A; Vasella, A	1
Baruch, BB; Engel, H; Fridman, M; Simhaev, L; Zada, SL	1
Aparicio, T; de Lorenzo, V; García-Gutiérrez, C; Lombó, F; Martínez-García, E; Torres-Sánchez, L; Villar, CJ	1
Cheng, P; Li, F; Li, J; Liu, R; Muhammad, I; Xiao, T; Yang, Y; Yu, H; Zhang, X	1
Becker, K; Gysin, M; Haldimann, K; Hobbie, SN; Plattner, M	1
Böttger, EC; Chow, CS; Crich, D; Gysin, M; Haldimann, K; Hobbie, SN; Janusic, T; Quirke, JCK; Schacht, J; Sha, SH; Sonousi, A; Vasella, A; Waduge, P; Xu, S	1
Bhatia, SK; Choi, TR; Gurav, R; Kim, HJ; Kim, SH; Lee, HS; Lee, SM; Park, S; Park, SL; Park, YL; Seo, SO; Song, HS; Sung, C; Yang, YH	1
Backlund, M; Cao, S; Ercan, O; Friberg, LE; Giachou, P; Grinberga, S; Hansen, J; Hobbie, SN; Hughes, D; Liepinsh, E; Petersson, A; Sou, T; Tomczak, M; Urbas, M; Vingsbo Lundberg, C; Zabicka, D	1
Andrén, PE; Aranzana-Climent, V; Becker, K; Böttger, EC; Cao, S; Friberg, LE; Haldimann, K; Hobbie, SN; Hughes, D; Nilsson, A; Platzack, B; Shariatgorji, R	1
Ding, HZ; Fu, JL; Jiang, HX; Wu, SL; Zhang, HL	1
Friberg, LE	1
Chi, HT; Deng, Z; Wu, L; Yu, Y; Zhang, Q	1
Bordeleau, E; Evdokimova, E; Koteva, K; Savchenko, A; Stogios, PJ; Wright, GD	1
Garofalo, R; Günenç, AN; Lenz, C; Rodnina, MV; Samatova, E; Urlaub, H; Wohlgemuth, I	1
Chen, L; Du, H; Fouts, DE; Hao, M; Kreiswirth, BN; Satlin, M; Schuyler, J; Shashkina, E; Zhang, H	1
Abrantes, P; Albuquerque, T; Amaro, A; Costa, SS; Couto, I; Ferreira, C; Feßler, AT; Kadlec, K; Kaspar, H; Morais, C; Pomba, C; Ribeiro, R; Schink, AK; Schwarz, S	1
Kulik, A; Maier, H; Martinovic, L; Mitousis, L; Musiol-Kroll, EM; Stiefel, A; Stockert, S; Wohlleben, W	1
Andrén, PE; Becker, K; Berruga-Fernández, T; Böttger, EC; Brönstrup, M; Cao, S; Crich, D; Erlandsson, M; Friberg, LE; Grinberga, S; Haldimann, K; Hansen, J; Hobbie, SN; Hotop, SK; Hughes, D; Huseby, DL; Kuka, J; Liepinsh, E; Lindmark, E; Nilsson, A; Platzack, B; Shariatgorji, R; Vingsbo Lundberg, C	1
Böttger, EC; Hobbie, SN; Ordway, DJ; Petrig, A; Sander, P; Selchow, P; Verma, D; Whittel, N	1
Gao, H; Liu, Y; Ni, X; Sun, J; Xia, H; Yan, D	1
Chirkova, A; Friberg, LE; Hobbie, SN; Lindberg, J; Palma Villar, R; Rosenborg, S; Zhao, C	1
Argüello, H; Cabrera-Rubio, R; Cotter, PD; Crispie, F; Garrido, JJ; Manzanilla, EG; Ortiz Sanjuán, JM	1
Ashley, EA; Becker, K; Gysin, M; Haldimann, K; Hinfonthong, P; Hobbie, SN; Hon, PY; Hopkins, J; Kaewphanderm, N; Kesteman, T; Ling, CL; Nguyen, TH; Pham, TD; Roberts, T; Sengduangphachanh, A; Simmalavong, M; Simpson, AJH; Tan, P; Tran, HH; Turner, P; van Doorn, HR; Vasoo, S	1
Ande, C; Böttger, EC; Crich, D; Haldimann, K; Hobbie, SN; Pirrone, MG; Vasella, A	1
Fan, PH; Liu, HW; Sato, S; Yeh, YC	1

Reviews

2 review(s) available for tobramycin and apramycin

Article	Year
Do nonclinical uses of antibiotics make a difference? Infection control and hospital epidemiology, 1994, Volume: 15, Issue:7 Topics: Animal Husbandry; Animals; Anti-Bacterial Agents; Aquaculture; Bacteria; Drug Resistance, Microbial; Drug Utilization; Humans; Nebramycin	1994
Evolution of bacterial resistance to antibiotics during the last three decades. International microbiology : the official journal of the Spanish Society for Microbiology, 1998, Volume: 1, Issue:4 Topics: Anti-Bacterial Agents; Cinnamates; DNA Transposable Elements; Drug Resistance, Microbial; Escherichia coli; Evolution, Molecular; Gram-Positive Bacteria; Haemophilus influenzae; Hygromycin B; Mycobacterium; Nebramycin; Plasmids	1998

Article

Year

Do nonclinical uses of antibiotics make a difference?

Infection control and hospital epidemiology, 1994, Volume: 15, Issue:7

Topics: Animal Husbandry; Animals; Anti-Bacterial Agents; Aquaculture; Bacteria; Drug Resistance, Microbial; Drug Utilization; Humans; Nebramycin

1994

Evolution of bacterial resistance to antibiotics during the last three decades.

International microbiology : the official journal of the Spanish Society for Microbiology, 1998, Volume: 1, Issue:4

Topics: Anti-Bacterial Agents; Cinnamates; DNA Transposable Elements; Drug Resistance, Microbial; Escherichia coli; Evolution, Molecular; Gram-Positive Bacteria; Haemophilus influenzae; Hygromycin B; Mycobacterium; Nebramycin; Plasmids

1998

Trials

6 trial(s) available for tobramycin and apramycin

Article	Year
An evaluation of apramycin soluble powder for the treatment of naturally acquired Escherichia coli infections in broilers. Journal of veterinary pharmacology and therapeutics, 1986, Volume: 9, Issue:3 Topics: Animals; Anti-Bacterial Agents; Body Weight; Chickens; Clinical Trials as Topic; Escherichia coli Infections; Nebramycin; Poultry Diseases	1986
Effects of antibiotic regimens on the fecal shedding patterns of pigs infected with salmonella typhimurium. Journal of food protection, 2000, Volume: 63, Issue:6 Topics: Animals; Anti-Bacterial Agents; Drug Therapy, Combination; Feces; Female; Male; Nebramycin; Oxytetracycline; Salmonella Infections, Animal; Salmonella typhimurium; Swine; Swine Diseases; Time Factors	2000
Effects of supplementation of beta-glucans on growth performance, nutrient digestibility, and immunity in weanling pigs. Journal of animal science, 2006, Volume: 84, Issue:6 Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Anti-Bacterial Agents; Antibodies, Bacterial; beta-Glucans; Carbadox; Diet; Dietary Supplements; Digestion; Dose-Response Relationship, Drug; Male; Nebramycin; Pasteurella multocida; Swine; Weaning	2006
Early modulation of the cecal microbial activity in the young rabbit with rapidly fermentable fiber: impact on health and growth. Journal of animal science, 2014, Volume: 92, Issue:12 Topics: Age Factors; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Anti-Bacterial Agents; Cecum; Diet; Dietary Fiber; Digestion; Diterpenes; Eating; Fatty Acids; Fermentation; Microbiota; Nebramycin; Rabbits	2014
Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose. The Journal of antimicrobial chemotherapy, 2022, 09-30, Volume: 77, Issue:10 Topics: Aminoglycosides; Anti-Bacterial Agents; Humans; Infusions, Intravenous; Nebramycin	2022
Using Shotgun Sequencing to Describe the Changes Induced by In-Feed Zinc Oxide and Apramycin in the Microbiomes of Pigs One Week Postweaning. Microbiology spectrum, 2022, 08-31, Volume: 10, Issue:4 Topics: Animals; Anti-Bacterial Agents; Diarrhea; Escherichia coli; Gastrointestinal Microbiome; Nebramycin; Swine; Zinc Oxide	2022

Other Studies

146 other study(ies) available for tobramycin and apramycin

Article	Year
Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesis. European journal of biochemistry, 1979, Volume: 99, Issue:3 Topics: Anti-Bacterial Agents; Bacillus megaterium; Bacterial Proteins; Escherichia coli; Hygromycin B; Leucine; Nebramycin; Poly U; Protein Biosynthesis; Protoplasts; Puromycin	1979
Apramycin, a unique aminocyclitol antibiotic. The Journal of organic chemistry, 1976, Jun-11, Volume: 41, Issue:12 Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Nebramycin; Streptomyces; X-Ray Diffraction	1976
Carbon-13 nuclear magnetic resonance spectroscopy of naturally occurring substances. XXXIX. Apramycin--an application of amine protonation parameters. The Journal of organic chemistry, 1976, Feb-20, Volume: 41, Issue:4 Topics: Aminoglycosides; Anti-Bacterial Agents; Magnetic Resonance Spectroscopy; Methods; Nebramycin	1976
Interspecies differences in the pharmacokinetics of kanamycin and apramycin. Veterinary research communications, 1992, Volume: 16, Issue:4 Topics: Animals; Body Weight; Chickens; Columbidae; Female; Goats; Half-Life; Injections, Intravenous; Kanamycin; Male; Models, Statistical; Nebramycin; Rabbits; Sheep; Species Specificity	1992
Apramycin resistance plasmids in Escherichia coli: possible transfer to Salmonella typhimurium in calves. Epidemiology and infection, 1992, Volume: 108, Issue:2 Topics: Animals; Cattle; Cattle Diseases; Escherichia coli; Nebramycin; R Factors; Salmonella Infections, Animal; Salmonella typhimurium	1992
Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius. Gene, 1991, Jun-15, Volume: 102, Issue:1 Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cloning, Molecular; Drug Resistance, Microbial; Escherichia coli; Kanamycin Resistance; Methyltransferases; Molecular Sequence Data; Nebramycin; Restriction Mapping; RNA, Ribosomal, 16S; Sequence Homology, Nucleic Acid; Streptomyces; Transcription, Genetic	1991
Transposition of Tn5096 and other IS493 derivatives in Streptomyces griseofuscus. Journal of bacteriology, 1991, Volume: 173, Issue:3 Topics: Anti-Bacterial Agents; Base Sequence; Cloning, Molecular; DNA Transposable Elements; Drug Resistance, Microbial; Macrolides; Molecular Sequence Data; Nebramycin; Plasmids; Restriction Mapping; Spores, Bacterial; Streptomyces; Temperature	1991
Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA. The EMBO journal, 1991, Volume: 10, Issue:10 Topics: Aminoglycosides; Anti-Bacterial Agents; Autoradiography; Escherichia coli; Nebramycin; Neomycin; Nucleic Acid Conformation; Nucleic Acid Hybridization; RNA, Ribosomal, 16S	1991
Aminoglycoside acetyltransferase 3-IV (aacC4) and hygromycin B 4-I phosphotransferase (hphB) in bacteria isolated from human and animal sources. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:10 Topics: Acetylation; Acetyltransferases; Animals; Autoradiography; Cattle; Drug Resistance, Microbial; Enterobacteriaceae; Genes, Bacterial; Humans; Hybridization, Genetic; Hygromycin B; Microbial Sensitivity Tests; Nebramycin; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Plasmids; Transfection	1990
High genetic homology between plasmids of human and animal origins conferring resistance to the aminoglycosides gentamicin and apramycin. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:3 Topics: Animals; Cattle; DNA; Drug Resistance, Microbial; Escherichia coli; Gentamicins; Humans; Nebramycin; Nucleic Acid Hybridization; Plasmids; Salmonella; Swine	1991
Phenotypic suppression by aminoglycoside antibiotics of mutations blocking erythromycin biosynthesis in Saccharopolyspora erythraea. Journal of bacteriology, 1990, Volume: 172, Issue:11 Topics: Anti-Bacterial Agents; Erythromycin; Gram-Positive Bacteria; Mutation; Nebramycin; Phenotype; Suppression, Genetic; Transformation, Bacterial	1990
Resistance to apramycin in two enterobacterial clinical isolates: detection of a 3-N-acetyltransferase IV. Journal of chemotherapy (Florence, Italy), 1990, Volume: 2, Issue:4 Topics: Acetyltransferases; Drug Resistance, Microbial; Electrophoresis, Agar Gel; Escherichia coli; Humans; Klebsiella pneumoniae; Nebramycin; Plasmids; Species Specificity	1990
Detection of apramycin resistant Enterobacteriaceae in hospital isolates. FEMS microbiology letters, 1989, Oct-15, Volume: 52, Issue:3 Topics: Animals; Anti-Bacterial Agents; Cattle; Cross Infection; DNA Probes; Drug Resistance, Microbial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Nebramycin; Nucleic Acid Hybridization; R Factors; Replicon; Transfection	1989
The effect of avilamycin in the control of stress-induced post-weaning diarrhoea in piglets. Journal of veterinary pharmacology and therapeutics, 1989, Volume: 12, Issue:3 Topics: Animal Feed; Animals; Diarrhea; Eating; Female; Growth Substances; Male; Nebramycin; Quinoxalines; Random Allocation; Stress, Physiological; Swine; Swine Diseases; Weaning; Weight Gain	1989
[Pseudomonas aeruginosa infections in turkey poults and treatment trials with apramycin]. Berliner und Munchener tierarztliche Wochenschrift, 1987, Feb-01, Volume: 100, Issue:2 Topics: Animals; Anti-Bacterial Agents; Nebramycin; Poultry Diseases; Pseudomonas aeruginosa; Pseudomonas Infections; Turkeys	1987
[Comparative study of apramycin-resistant microorganisms isolated from man and animals]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1988, Volume: 33, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bacteria; Cross Infection; Drug Resistance, Microbial; Environmental Microbiology; Escherichia coli Infections; Humans; Microbial Sensitivity Tests; Nebramycin; Swine; Swine Diseases	1988
AAC(1): a new aminoglycoside-acetylating enzyme modifying the Cl aminogroup of apramycin. The Journal of antimicrobial chemotherapy, 1987, Volume: 20, Issue:6 Topics: Acetyltransferases; Anti-Bacterial Agents; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Drug Resistance, Microbial; Escherichia coli; Magnetic Resonance Spectroscopy; Nebramycin	1987
[Chronic 90-day toxicity of apramycin in chickens]. Veterinarno-meditsinski nauki, 1987, Volume: 24, Issue:9 Topics: Animals; Anti-Bacterial Agents; Blood Cells; Body Weight; Chickens; Dose-Response Relationship, Drug; Female; Male; Nebramycin; Time Factors	1987
Emergence of aminoglycoside 3-N-acetyltransferase IV in Escherichia coli and Salmonella typhimurium isolated from animals in France. Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:2 Topics: Acetyltransferases; Animals; Cattle; Cattle Diseases; Disease Outbreaks; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Feces; France; Gentamicins; Nebramycin; Phenotype; R Factors; Salmonella Infections, Animal; Salmonella typhimurium	1986
Characterization of plasmids conferring resistance to gentamicin and apramycin in strains of Salmonella typhimurium phage type 204c isolated in Britain. The Journal of hygiene, 1986, Volume: 97, Issue:3 Topics: Acetyltransferases; Animals; Anti-Bacterial Agents; Bacteriocin Plasmids; Bacteriophage Typing; Cattle; Gentamicins; Humans; Nebramycin; R Factors; Salmonella typhimurium; United Kingdom	1986
Apramycin and gentamicin resistance in Escherichia coli and salmonellas isolated from farm animals. The Journal of hygiene, 1986, Volume: 97, Issue:3 Topics: Acetyltransferases; Animals; Animals, Domestic; Anti-Bacterial Agents; Cattle; Conjugation, Genetic; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Infections; Gentamicins; Nebramycin; Poultry; R Factors; Salmonella; Salmonella Infections, Animal; Salmonella typhimurium; Sheep; Swine; United Kingdom	1986
[Apramycin blood concentrations and distribution in the body of calves after different methods of administration]. Veterinarno-meditsinski nauki, 1987, Volume: 24, Issue:1 Topics: Animals; Anti-Bacterial Agents; Body Burden; Cattle; Female; Kinetics; Male; Meat; Nebramycin; Time Factors; Tissue Distribution	1987
[Subchronic toxicity of apramycin in pigs]. Veterinarno-meditsinski nauki, 1987, Volume: 24, Issue:7 Topics: Animals; Anti-Bacterial Agents; Blood Cell Count; Body Weight; Chronic Disease; Dose-Response Relationship, Drug; Female; Hemoglobins; Male; Nebramycin; Swine; Swine Diseases; Time Factors	1987
Apramycin: minimal inhibitory concentrations for avian Escherichia coli and serum levels after intramuscular injection in turkeys. Journal of veterinary pharmacology and therapeutics, 1985, Volume: 8, Issue:1 Topics: Age Factors; Animals; Anti-Bacterial Agents; Escherichia coli; Escherichia coli Infections; Injections, Intramuscular; Nebramycin; Poultry Diseases; Turkeys	1985
Resistance to gentamicin and apramycin in Escherichia coli from calves in France. The Veterinary record, 1985, Jul-27, Volume: 117, Issue:4 Topics: Animals; Anti-Bacterial Agents; Cattle; Drug Resistance, Microbial; Escherichia coli; France; Gentamicins; Microbial Sensitivity Tests; Nebramycin	1985
Clinical pharmacology of apramycin in calves. Journal of veterinary pharmacology and therapeutics, 1985, Volume: 8, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Cattle; Cattle Diseases; Female; Injections, Intramuscular; Injections, Intravenous; Kinetics; Male; Nebramycin	1985
Analysis of a bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing. Nucleic acids research, 1983, Oct-11, Volume: 11, Issue:19 Topics: Anti-Bacterial Agents; Base Sequence; DNA Restriction Enzymes; Drug Resistance, Microbial; Escherichia coli; Genes, Bacterial; Hygromycin B; Nebramycin; Nucleic Acid Hybridization; Operon; Plasmids; Protein Biosynthesis; Transcription, Genetic	1983
[A comparison of the effectiveness of furazolidone and apramycin in the control of colibacillosis in weaned piglets]. Tijdschrift voor diergeneeskunde, 1983, Apr-15, Volume: 108, Issue:8 Topics: Animals; Anti-Bacterial Agents; Edema Disease of Swine; Escherichia coli Infections; Furazolidone; Nebramycin; Swine; Swine Diseases	1983
Resistance to apramycin in Escherichia coli isolated from animals: detection of a novel aminoglycoside-modifying enzyme. Journal of general microbiology, 1984, Volume: 130, Issue:3 Topics: Acetyltransferases; Aminoglycosides; Animals; Anti-Bacterial Agents; Drug Resistance, Microbial; Escherichia coli; Nebramycin; Neomycin; Plasmids	1984
[The effect of apramycin on bacterial contamination and the survival of boar semen during a short preservation period]. Veterinarni medicina, 1984, Volume: 29, Issue:8 Topics: Animals; Anti-Bacterial Agents; Cell Survival; Male; Nebramycin; Semen; Semen Preservation; Spermatozoa; Swine	1984
Aminoglycoside antibiotics. XIV. Synthesis and activity of 6-O-(3-amino-3-deoxy-alpha-D-glucopyranosyl)-and 5-O-(beta-D-ribofuranosyl)apramycins. The Journal of antibiotics, 1981, Volume: 34, Issue:11 Topics: Acetylation; Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry, Physical; Magnetic Resonance Spectroscopy; Nebramycin	1981
Pharmacokinetics of apramycin in Japanese quails. Journal of veterinary pharmacology and therapeutics, 1994, Volume: 17, Issue:5 Topics: Administration, Oral; Animals; Coturnix; Female; Injections, Intravenous; Male; Models, Biological; Nebramycin; Regression Analysis; Sex Characteristics; Species Specificity	1994
Urinary isolates of apramycin-resistant Escherichia coli and Klebsiella pneumoniae from Dublin. Epidemiology and infection, 1995, Volume: 114, Issue:1 Topics: Conjugation, Genetic; Drug Resistance, Microbial; Escherichia coli; Gene Transfer Techniques; Humans; Ireland; Klebsiella pneumoniae; Microbial Sensitivity Tests; Nebramycin; Plasmids; Species Specificity; Urine	1995
Apramycin-resistant Escherichia coli isolated from pigs and a stockman. Epidemiology and infection, 1994, Volume: 112, Issue:3 Topics: Agricultural Workers' Diseases; Animals; Cats; Diarrhea; Disease Outbreaks; DNA Probes; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Infections; Feces; Female; Humans; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Nebramycin; Nucleic Acid Hybridization; R Factors; Serotyping; Swine; Swine Diseases	1994
Gentamicin resistance in clinical isolates of Escherichia coli encoded by genes of veterinary origin. Journal of medical microbiology, 1994, Volume: 40, Issue:3 Topics: Acetyltransferases; Animals; Conjugation, Genetic; DNA Probes; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Gentamicins; Humans; Hygromycin B; Klebsiella pneumoniae; Nebramycin; Nucleic Acid Hybridization; R Factors; Restriction Mapping; Tobramycin	1994
Adaptation of the Sensititre broth microdilution technique to antimicrobial susceptibility testing of Mycoplasma hyopneumoniae. Veterinary microbiology, 1993, Volume: 36, Issue:3-4 Topics: Amoxicillin; Animals; Anti-Infective Agents, Urinary; Drug Resistance, Microbial; Erythromycin; Lincomycin; Microbial Sensitivity Tests; Mycoplasma; Nebramycin; Nitrofurans; Oxazolidinones; Oxytetracycline; Reproducibility of Results; Spectinomycin; Swine; Tylosin	1993
Replicon typing characterization of plasmids encoding resistance to gentamicin and apramycin in Escherichia coli and Salmonella typhimurium isolated from human and animal sources in Belgium. Epidemiology and infection, 1993, Volume: 111, Issue:2 Topics: Animals; Belgium; Cattle; Citrobacter freundii; Conjugation, Genetic; DNA, Bacterial; Drug Resistance, Microbial; Electrophoresis, Agar Gel; Enterobacteriaceae; Escherichia coli; Gentamicins; Humans; Klebsiella pneumoniae; Nebramycin; Nucleic Acid Hybridization; R Factors; Replicon; Salmonella typhimurium	1993
Human isolates of apramycin-resistant Escherichia coli which contain the genes for the AAC(3)IV enzyme. Epidemiology and infection, 1993, Volume: 110, Issue:2 Topics: Acetyltransferases; Adult; Aged; DNA Probes; DNA, Bacterial; Drug Resistance, Microbial; England; Escherichia coli; Escherichia coli Infections; Female; Gentamicins; Humans; Male; Microbial Sensitivity Tests; Nebramycin; Pregnancy	1993
A genetic study of apramycin-resistant mutants of Escherichia coli. Journal of basic microbiology, 1993, Volume: 33, Issue:1 Topics: Chromosome Mapping; Drug Resistance, Microbial; Escherichia coli; Mutation; Nebramycin	1993
Serum and milk concentrations of apramycin in lactating cows, ewes and goats. Journal of veterinary pharmacology and therapeutics, 1995, Volume: 18, Issue:5 Topics: Animals; Anti-Bacterial Agents; Cattle; Female; Goats; Injections, Intramuscular; Injections, Intravenous; Lactation; Linear Models; Mammary Glands, Animal; Mastitis; Mastitis, Bovine; Milk; Nebramycin; Sheep; Sheep Diseases; Species Specificity	1995
Antibiotic resistant phage types of Salmonella typhimurium in dairy cattle. Australian veterinary journal, 1996, Volume: 73, Issue:5 Topics: Animals; Anti-Bacterial Agents; Bacteriophage Typing; Cattle; Cattle Diseases; Diarrhea; Drug Resistance, Microbial; Female; Nebramycin; Salmonella Infections, Animal; Salmonella Phages; Salmonella typhimurium; Spectinomycin; Victoria	1996
Minimum inhibitory concentrations of intestinal Escherichia coli from broiler chickens after oral administration of apramycin. The Journal of applied bacteriology, 1996, Volume: 80, Issue:1 Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Chickens; Cloaca; Escherichia coli; Microbial Sensitivity Tests; Nebramycin	1996
Apramycin resistance as a selective marker for gene transfer in mycobacteria. Journal of bacteriology, 1996, Volume: 178, Issue:21 Topics: Anti-Bacterial Agents; Conjugation, Genetic; Drug Resistance, Microbial; Electroporation; Gene Transfer Techniques; Genetic Engineering; Genetic Vectors; Mycobacterium; Nebramycin; Transformation, Genetic	1996
Growth performance and intestinal microbial populations of growing pigs fed diets containing sucrose thermal oligosaccharide caramel. Journal of animal science, 1997, Volume: 75, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bacteria, Anaerobic; Bifidobacterium; Candy; Carbohydrates; Cecum; Diet; Dietary Sucrose; Enterobacteriaceae; Female; Food Coloring Agents; Intestines; Lactobacillus; Male; Nebramycin; Oligosaccharides; Organic Chemicals; Swine	1997
[Characteristics of Streptomyces kanamyceticus mutants resistant to aminoglycoside antibiotics]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1996, Volume: 41, Issue:6 Topics: Anti-Bacterial Agents; Drug Resistance, Microbial; Genes, Bacterial; Genetic Variation; Gentamicins; Kanamycin; Kanamycin Resistance; Microbial Sensitivity Tests; Mutation; Nebramycin; Neomycin; Spores, Bacterial; Streptomyces	1996
Veterinary use of antimicrobial agents and problems of resistance in human bacterial infections. The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:2 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Cattle; Cattle Diseases; Drug Resistance, Microbial; Humans; Nebramycin; Swine; Swine Diseases	1997
Antimicrobial resistance of Salmonella enterica typhimurium DT104 isolates and investigation of strains with transferable apramycin resistance. Epidemiology and infection, 1997, Volume: 118, Issue:2 Topics: Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Drug Resistance, Microbial; Gentamicins; Humans; Microbial Sensitivity Tests; Nebramycin; R Factors; Retrospective Studies; Salmonella Infections, Animal; Salmonella typhimurium; Scotland	1997
Incidence of antibiotic resistance in fecal Escherichia coli isolated from commercial swine farms. Journal of animal science, 1998, Volume: 76, Issue:2 Topics: Animals; Anti-Bacterial Agents; Carbadox; Chi-Square Distribution; Drug Resistance, Microbial; Escherichia coli; Feces; Female; Gentamicins; Male; Microbial Sensitivity Tests; Nebramycin; Neomycin; Oxytetracycline; Swine	1998
Selection of suitable marker genes for the development of cloning vectors and electroporation in different strains of Amycolatopsis mediterranei. Microbiological research, 1998, Volume: 153, Issue:3 Topics: Actinomycetaceae; Anti-Bacterial Agents; DNA, Bacterial; Drug Resistance, Microbial; Electroporation; Erythromycin; Escherichia coli; Genetic Markers; Genetic Vectors; Nebramycin; Plasmids; Restriction Mapping; Thiostrepton	1998
Postantibiotic and physiological effects of tilmicosin, tylosin, and apramycin at subminimal and suprainhibitory concentrations on some swine and bovine respiratory tract pathogens. International journal of antimicrobial agents, 1999, Volume: 12, Issue:3 Topics: Animals; Anti-Bacterial Agents; Cattle; Gram-Negative Bacteria; Hemolysis; Macrolides; Microbial Sensitivity Tests; Nebramycin; Respiratory System; Swine; Tylosin	1999
The antibacterial and NMDA receptor activating properties of aminoglycosides are dissociable. European journal of pharmacology, 2000, Jan-03, Volume: 387, Issue:1 Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Binding, Competitive; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Escherichia coli; Female; Male; Membrane Potentials; Membranes; Nebramycin; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Complementary; Staphylococcus aureus; Tritium; Xenopus	2000
Antimicrobial resistance in enteric porcine Escherichia coli strains in Spain. The Veterinary record, 2000, Jun-10, Volume: 146, Issue:24 Topics: Amoxicillin; Animals; Animals, Newborn; Anti-Bacterial Agents; Cephalosporins; Colistin; Diarrhea; Drug Resistance, Microbial; Enrofloxacin; Escherichia coli; Escherichia coli Infections; Fluoroquinolones; Microbial Sensitivity Tests; Nebramycin; Neomycin; Quinolones; Spain; Swine; Swine Diseases	2000
Genomewide insertional mutagenesis in Streptomyces coelicolor reveals additional genes involved in morphological differentiation. Proceedings of the National Academy of Sciences of the United States of America, 2000, Aug-15, Volume: 97, Issue:17 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Proteins; Base Sequence; Chromosomes, Bacterial; DNA Transposable Elements; Genes, Bacterial; Genome, Bacterial; Microbial Sensitivity Tests; Molecular Sequence Data; Multigene Family; Mutagenesis, Insertional; Nebramycin; Phenotype; Physical Chromosome Mapping; Pigments, Biological; Recombination, Genetic; Sequence Alignment; Spores, Bacterial; Streptomyces	2000
Relative distribution and conservation of genes encoding aminoglycoside-modifying enzymes in Salmonella enterica serotype typhimurium phage type DT104. Applied and environmental microbiology, 2001, Volume: 67, Issue:1 Topics: Acetyltransferases; Animals; Anti-Bacterial Agents; Bacteriophage Typing; Drug Resistance, Microbial; Gentamicins; Kanamycin Kinase; Kanamycin Resistance; Nebramycin; Salmonella Infections, Animal; Salmonella typhimurium; Streptomycin	2001
The effect of apramycin on colonization of pathogenic Escherichia coli in the intestinal tract of chicks. The veterinary quarterly, 2001, Volume: 23, Issue:2 Topics: Animals; Anti-Bacterial Agents; Bacteremia; Bacterial Adhesion; Cells, Cultured; Chickens; Colony Count, Microbial; Escherichia coli; Escherichia coli Infections; Food Deprivation; Intestines; Nebramycin; Poultry Diseases; Water Deprivation	2001
[Cloning of the sugar related biosynthesis gene cluster from Streptomyces tenebrarius H6]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2001, Volume: 17, Issue:3 Topics: Anti-Bacterial Agents; Cloning, Molecular; Glucose; Multigene Family; Nebramycin; Streptomyces; Thymine Nucleotides	2001
Evaluation of subtherapeutic use of the antibiotics apramycin and carbadox on the prevalence of antimicrobial-resistant Salmonella infection in swine. Journal of food protection, 2001, Volume: 64, Issue:12 Topics: Animals; Anti-Bacterial Agents; Carbadox; Drug Resistance, Multiple, Bacterial; Microbial Sensitivity Tests; Nebramycin; Prevalence; Salmonella; Salmonella Infections, Animal; Swine; Swine Diseases	2001
[Establishment of gene replacement/disruption system through homologous recombination in Amycolatopsis mediterranei U32]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2002, Volume: 18, Issue:4 Topics: Actinomycetales; DNA, Bacterial; Drug Resistance, Microbial; Genes, Bacterial; Mutagenesis; Nebramycin; Plasmids; Recombination, Genetic	2002
Characterization of resistance patterns and detection of apramycin resistance genes in Escherichia coli isolated from swine exposed to various environmental conditions. International journal of food microbiology, 2003, Dec-15, Volume: 89, Issue:1 Topics: Animal Husbandry; Animals; Anti-Bacterial Agents; Colony Count, Microbial; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Feces; Microbial Sensitivity Tests; Nebramycin; Polymerase Chain Reaction; Random Allocation; Swine; Swine Diseases	2003
Characterization of antimicrobial resistant Salmonella Kinshasa from dairy calves in Texas. Letters in applied microbiology, 2004, Volume: 38, Issue:2 Topics: Ampicillin; Animals; Anti-Bacterial Agents; Cattle; Chloramphenicol; Conjugation, Genetic; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Feces; Fluoroquinolones; Gene Transfer, Horizontal; Microbial Sensitivity Tests; Nebramycin; Neomycin; Oxytetracycline; Public Health; Risk Factors; Salmonella; Serotyping; Spectinomycin; Streptomycin; Sulfamethoxazole; Tetracycline; Texas	2004
Effects of mushroom and herb polysaccharides, as alternatives for an antibiotic, on the cecal microbial ecosystem in broiler chickens. Poultry science, 2004, Volume: 83, Issue:2 Topics: Agaricales; Animals; Anti-Bacterial Agents; Cecum; Chickens; Female; Hydrogen-Ion Concentration; Nebramycin; Plant Extracts; Plants, Medicinal; Polysaccharides; Probiotics; Random Allocation; Viscosity; Weight Gain	2004
Acquisition and epidemiology of antibiotic-resistant Escherichia coli in a cohort of newborn calves. The Journal of antimicrobial chemotherapy, 2004, Volume: 53, Issue:5 Topics: Ampicillin; Ampicillin Resistance; Animals; Animals, Newborn; Anti-Bacterial Agents; Anti-Infective Agents; Cattle; Cohort Studies; Colony Count, Microbial; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Feces; Microbial Sensitivity Tests; Nalidixic Acid; Nebramycin; Penicillins; Scotland	2004
Use of a novel allele of the Escherichia coli aacC4 aminoglycoside resistance gene as a genetic marker in mycobacteria. FEMS microbiology letters, 2004, May-15, Volume: 234, Issue:2 Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Genetic Markers; Gentamicins; Kanamycin; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Mycobacterium; Nebramycin; Plasmids; Restriction Mapping	2004
High frequency transfer and horizontal spread of apramycin resistance in calf faecal Escherichia coli. The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:2 Topics: Acetyltransferases; Animals; Anti-Bacterial Agents; Cattle; Cluster Analysis; Conjugation, Genetic; DNA Primers; DNA, Bacterial; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Escherichia coli; Feces; Gene Transfer, Horizontal; Genotype; Microbial Sensitivity Tests; Nebramycin; Phenotype; Plasmids; Reverse Transcriptase Polymerase Chain Reaction	2004
Identification and functional analysis of dTDP-glucose-4,6-dehydratase gene and its linked gene cluster in an aminoglycoside antibiotics producer of Streptomyces tenebrarius H6. Current microbiology, 2004, Volume: 49, Issue:2 Topics: Amino Acid Sequence; Chromosomes, Bacterial; Clostridium; DNA, Bacterial; Gene Deletion; Gene Order; Genes, Bacterial; Glycosyltransferases; Hydro-Lyases; Kanamycin; Mannosyltransferases; Molecular Sequence Data; Multigene Family; Mutagenesis, Insertional; Nebramycin; Open Reading Frames; Pseudomonas putida; Rhamnose; Sequence Analysis, DNA; Sequence Homology; Streptomyces; Thymine Nucleotides; Tobramycin; Xanthomonas	2004
Pharmacokinetics of gentamicin and apramycin in turkeys roosters and hens in the context of pharmacokinetic-pharmacodynamic relationships. Journal of veterinary pharmacology and therapeutics, 2004, Volume: 27, Issue:5 Topics: Animals; Cross-Over Studies; Drug Interactions; Escherichia coli; Female; Gentamicins; Gram-Negative Bacterial Infections; Injections, Intramuscular; Injections, Intravenous; Male; Microbial Sensitivity Tests; Nebramycin; Poultry Diseases; Salmonella; Turkeys	2004
Combating drug-resistant bacteria: small molecule mimics of plasmid incompatibility as antiplasmid compounds. Journal of the American Chemical Society, 2004, Dec-01, Volume: 126, Issue:47 Topics: Aminoglycosides; Base Sequence; beta-Lactamases; Biomimetic Materials; DNA Helicases; DNA-Binding Proteins; Drug Resistance, Multiple, Bacterial; Escherichia coli; Nebramycin; Nucleic Acid Conformation; R Factors; RNA, Messenger; RNA, Untranslated; Trans-Activators	2004
Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex. Angewandte Chemie (International ed. in English), 2005, Apr-29, Volume: 44, Issue:18 Topics: Anti-Bacterial Agents; Base Pairing; Base Sequence; Crystallography, X-Ray; Glycosides; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Nebramycin; RNA	2005
Cloning and preliminary characterization of lh3 gene encoding a putative acetyltransferase from a rifamycin SV-producing strain Amycolatopsis mediterranei. Biotechnology letters, 2005, Volume: 27, Issue:15 Topics: Acetyltransferases; Actinomycetales; Amino Acid Sequence; Cloning, Molecular; DNA; Erythromycin; Gene Expression Regulation, Fungal; Hydrogen Peroxide; Molecular Sequence Data; Mutation; Nebramycin; Open Reading Frames; Phenotype; Physical Chromosome Mapping; Plasmids; Protein Structure, Tertiary; Recombination, Genetic; Repressor Proteins; Rifamycins; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Transcription Factors	2005
Effects of antibiotic use in sows on resistance of E. coli and Salmonella enterica Typhimurium in their offspring. Foodborne pathogens and disease, 2005,Fall, Volume: 2, Issue:3 Topics: Animals; Animals, Newborn; Animals, Suckling; Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Feces; Female; Microbial Sensitivity Tests; Nebramycin; Oxytetracycline; Pregnancy; Random Allocation; Salmonella Infections, Animal; Salmonella typhimurium; Swine; Swine Diseases	2005
Pretreatment of apramycin wastewater by catalytic wet air oxidation. Journal of environmental sciences (China), 2005, Volume: 17, Issue:4 Topics: Air; Biodegradation, Environmental; Catalysis; Drug Industry; Industrial Waste; Nebramycin; Oxidation-Reduction; Water Pollutants, Chemical	2005
The kinetic mechanism of AAC3-IV aminoglycoside acetyltransferase from Escherichia coli. Biochemistry, 2005, Dec-13, Volume: 44, Issue:49 Topics: Acetyltransferases; Anti-Bacterial Agents; Calorimetry; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Humans; Hydrogen-Ion Concentration; Isotopes; Molecular Structure; Nebramycin; Substrate Specificity	2005
Susceptibility of Escherichia coli from growing piglets receiving antimicrobial feed additives. Foodborne pathogens and disease, 2005,Winter, Volume: 2, Issue:4 Topics: Animal Feed; Animals; Anti-Infective Agents; Carbadox; Chlortetracycline; Drug Resistance, Bacterial; Escherichia coli; Feces; Food Additives; Gentamicins; Microbial Sensitivity Tests; Nebramycin; Swine	2005
Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site. Nucleic acids research, 2006, Volume: 34, Issue:2 Topics: Animals; Crystallography, X-Ray; Genetic Code; Humans; Models, Molecular; Nebramycin; Nucleic Acid Conformation; Ribosomes; RNA, Bacterial; RNA, Protozoan; RNA, Ribosomal, 16S; RNA, Ribosomal, 18S; Tetrahymena thermophila	2006
Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding site complexed with apramycin. Angewandte Chemie (International ed. in English), 2006, May-12, Volume: 45, Issue:20 Topics: Aminoglycosides; Anti-Bacterial Agents; Base Pairing; Crystallography, X-Ray; Cytoplasm; Genetic Code; Humans; Nebramycin; Nucleic Acid Conformation; Ribosomes	2006
Correlation between apramycin and gentamicin use in pigs and an increasing reservoir of gentamicin-resistant Escherichia coli. The Journal of antimicrobial chemotherapy, 2006, Volume: 58, Issue:1 Topics: Animals; Anti-Bacterial Agents; Denmark; Drug Resistance, Multiple, Bacterial; Drug Utilization; Escherichia coli; Gentamicins; Nebramycin; Swine; Time Factors; Veterinary Drugs	2006
Glycine origin of the methyl substituent on C7'-N of octodiose for the biosynthesis of apramycin. Science in China. Series C, Life sciences, 2006, Volume: 49, Issue:4 Topics: Carbohydrate Sequence; Carbon; Carbon Isotopes; Culture Media; Glycine; Molecular Sequence Data; Nebramycin; Nitrogen; Saccharopolyspora; Serine; Threonine	2006
Enhancement of bacterial competitive fitness by apramycin resistance plasmids from non-pathogenic Escherichia coli. Biology letters, 2006, Sep-22, Volume: 2, Issue:3 Topics: Animals; Anti-Bacterial Agents; Cattle; Conjugation, Genetic; Drug Resistance; Drug Resistance, Bacterial; Escherichia coli; Gene Transfer Techniques; Gene Transfer, Horizontal; Models, Genetic; Nebramycin; Phenotype; Plasmids	2006
Crystallographic studies of Homo sapiens ribosomal decoding A site complexed with aminoglycosides. Nucleic acids symposium series (2004), 2005, Issue:49 Topics: Aminoglycosides; Anti-Bacterial Agents; Crystallography, X-Ray; Humans; Nebramycin; Paromomycin; RNA; RNA, Mitochondrial; RNA, Ribosomal; Tobramycin	2005
Evaluation of a survey approach to estimating the prevalence of cattle carrying antimicrobial-resistant Escherichia coli. Veterinary journal (London, England : 1997), 2008, Volume: 175, Issue:3 Topics: Ampicillin; Animals; Anti-Infective Agents; Cattle; Cattle Diseases; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Feces; Microbial Sensitivity Tests; Nalidixic Acid; Nebramycin; Population Surveillance; Prevalence; Scotland	2008
Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites. Chembiochem : a European journal of chemical biology, 2007, Sep-24, Volume: 8, Issue:14 Topics: Aminoglycosides; Base Sequence; Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Kinetics; Luciferases; Models, Chemical; Molecular Conformation; Molecular Sequence Data; Nebramycin; Nucleic Acid Conformation; Paromomycin; Protein Binding; Ribosomes; RNA	2007
Aminoglycoside binding to the HIV-1 RNA dimerization initiation site: thermodynamics and effect on the kissing-loop to duplex conversion. Nucleic acids research, 2007, Volume: 35, Issue:21 Topics: 5' Untranslated Regions; Aminoglycosides; Anti-Bacterial Agents; Antiviral Agents; Binding Sites; Calorimetry; Cinnamates; Dimerization; HIV-1; Hygromycin B; Models, Molecular; Nebramycin; Nucleic Acid Conformation; Paromomycin; RNA, Viral; Thermodynamics	2007
Marker removal from actinomycetes genome using Flp recombinase. Gene, 2008, Aug-01, Volume: 419, Issue:1-2 Topics: Actinomycetales; Chromosomes, Fungal; DNA Nucleotidyltransferases; Drug Resistance, Microbial; Gene Expression; Genes, Synthetic; Genetic Engineering; Genetic Markers; Genome, Fungal; Nebramycin; Recombination, Genetic; Streptomyces coelicolor; Streptomyces lividans	2008
A new post-PKS modification process in the carbamoyltransferase gene inactivation strain of Streptomyces hygroscopicus 17997. The Journal of antibiotics, 2008, Volume: 61, Issue:6 Topics: Antibiotics, Antineoplastic; Benzoquinones; Carboxyl and Carbamoyl Transferases; Cell Line, Tumor; Cytotoxins; Gene Silencing; Genetic Engineering; Humans; Lactams, Macrocyclic; Multigene Family; Mutagenesis, Insertional; Nebramycin; Polyketide Synthases; Streptomyces	2008
Structural features and oxidative stress towards plasmid DNA of apramycin copper complex. Dalton transactions (Cambridge, England : 2003), 2009, Feb-21, Issue:7 Topics: Antioxidants; Ascorbic Acid; Circular Dichroism; Copper; DNA; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Chemical; Nebramycin; Oxidants; Oxidative Stress; Plasmids; Thermodynamics	2009
Resistance patterns and detection of aac(3)-IV gene in apramycin-resistant Escherichia coli isolated from farm animals and farm workers in northeastern of China. Research in veterinary science, 2009, Volume: 87, Issue:3 Topics: Animals; Anti-Bacterial Agents; Chickens; China; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Humans; Nebramycin; Occupational Exposure; Poultry Diseases; Swine; Swine Diseases	2009
Field trial evaluating changes in prevalence and patterns of antimicrobial resistance among Escherichia coli and Enterococcus spp. isolated from growing broilers medicated with enrofloxacin, apramycin and amoxicillin. Veterinary microbiology, 2009, Nov-18, Volume: 139, Issue:3-4 Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Chickens; Drug Resistance, Multiple, Bacterial; Enrofloxacin; Enterococcus; Escherichia coli; Feces; Fluoroquinolones; Microbial Sensitivity Tests; Nebramycin; Poultry Diseases	2009
Structural features of apramycin bound at the bacterial ribosome a site as detected by NMR and CD spectroscopy. Chembiochem : a European journal of chemical biology, 2010, Jan-25, Volume: 11, Issue:2 Topics: Anti-Bacterial Agents; Bacterial Translocation; Binding Sites; Circular Dichroism; Magnetic Resonance Spectroscopy; Nebramycin; Ribosomes	2010
Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Cattle; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Sequence Data; Nebramycin; Polymerase Chain Reaction; Swine	2011
Apramycin and gentamicin resistances in indicator and clinical Escherichia coli isolates from farm animals in Korea. Foodborne pathogens and disease, 2011, Volume: 8, Issue:1 Topics: Animals; Animals, Domestic; Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Genes, Bacterial; Gentamicins; Korea; Microbial Sensitivity Tests; Nebramycin; Swine	2011
Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes. Applied and environmental microbiology, 2011, Volume: 77, Issue:15 Topics: Actinobacteria; Codon, Initiator; Diterpenes; Genes, Reporter; Genetic Vectors; Glucuronidase; Glycosides; Lysine; Nebramycin; Promoter Regions, Genetic; Protein Biosynthesis; Recombinant Fusion Proteins	2011
Detection and characterization of aparmycin-resistant Escherichia coli from humans in Korea. Microbial drug resistance (Larchmont, N.Y.), 2011, Volume: 17, Issue:4 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Conjugation, Genetic; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Infections; Gentamicins; Humans; Microbial Sensitivity Tests; Nebramycin; Polymerase Chain Reaction	2011
Synthesis, separation, and characterization of amphiphilic sulfated oligosaccharides enabled by reversed-phase ion pairing LC and LC-MS methods. Carbohydrate research, 2011, Dec-13, Volume: 346, Issue:17 Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Kanamycin; Nebramycin; Neomycin; Spectrometry, Mass, Electrospray Ionization; Sulfuric Acid Esters	2011
Engineering Streptomyces tenebrarius to synthesize single component of carbamoyl tobramycin. Letters in applied microbiology, 2012, Volume: 55, Issue:1 Topics: Anti-Bacterial Agents; Conjugation, Genetic; Fermentation; Gene Knockout Techniques; Genetic Engineering; Genetic Vectors; Multigene Family; Nebramycin; Streptomyces; Tobramycin	2012
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin. Proceedings of the National Academy of Sciences of the United States of America, 2012, Jul-03, Volume: 109, Issue:27 Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Binding Sites; Deafness; Drug Design; Gentamicins; Guinea Pigs; Hair Cells, Auditory; HEK293 Cells; Humans; Mice; Mitochondria; Mutagenesis; Mycobacterium; Nebramycin; Organ Culture Techniques; Protein Biosynthesis; Pseudomonas aeruginosa; Rabbits; Reticulocytes; Ribosomes; Staphylococcus aureus	2012
Unusual small plasmids carrying the novel resistance genes dfrK or apmA isolated from methicillin-resistant or -susceptible staphylococci. The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:10 Topics: Animals; Anti-Bacterial Agents; DNA, Bacterial; Drug Resistance, Bacterial; Gene Order; Humans; Methicillin-Resistant Staphylococcus aureus; Molecular Sequence Data; Nebramycin; Plasmids; Sequence Analysis, DNA; Sequence Homology; Staphylococcal Infections; Staphylococcus; Trimethoprim	2012
The impact of aminoglycosides on the dynamics of translation elongation. Cell reports, 2013, Feb-21, Volume: 3, Issue:2 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria; Fluorescence Resonance Energy Transfer; Gentamicins; Nebramycin; Nucleic Acid Conformation; Paromomycin; Peptide Chain Elongation, Translational; RNA, Ribosomal, 16S; RNA, Transfer, Amino Acyl	2013
High affinity of copper(II) towards amoxicillin, apramycin and ristomycin. Effect of these complexes on the catalytic activity of HDV ribozyme. Journal of inorganic biochemistry, 2013, Volume: 124 Topics: Amoxicillin; Catalysis; Copper; Electron Spin Resonance Spectroscopy; Hepatitis Delta Virus; Magnetic Resonance Spectroscopy; Nebramycin; Ristocetin; RNA, Catalytic; RNA, Viral	2013
Redesign of substrate specificity and identification of the aminoglycoside binding residues of Eis from Mycobacterium tuberculosis. Biochemistry, 2013, Jul-30, Volume: 52, Issue:30 Topics: Acetylation; Acetyltransferases; Amino Acid Sequence; Amino Acid Substitution; Aminoglycosides; Antibiotics, Antitubercular; Antigens, Bacterial; Bacterial Proteins; Binding Sites; Drug Resistance, Multiple, Bacterial; Kanamycin; Kinetics; Molecular Conformation; Mutant Proteins; Mycobacterium smegmatis; Mycobacterium tuberculosis; Nebramycin; Paromomycin; Recombinant Proteins; Sequence Alignment; Substrate Specificity	2013
Identification of the molecular attributes required for aminoglycoside activity against Leishmania. Proceedings of the National Academy of Sciences of the United States of America, 2013, Aug-13, Volume: 110, Issue:33 Topics: Crystallization; Gentamicins; Leishmania; Leishmaniasis; Models, Molecular; Molecular Structure; Nebramycin; Protein Binding; Protein Conformation; Ribosomal Proteins	2013
Prevalence and characterization of apramycin-resistant Salmonella enterica serotype Typhimurium isolated from healthy and diseased pigs in Korea during 1998 through 2009. Journal of food protection, 2013, Volume: 76, Issue:8 Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Escherichia coli; Food Safety; Gentamicins; Humans; Korea; Meat; Nebramycin; Prevalence; Salmonella typhimurium; Swine; Tobramycin	2013
Hygromycin B and apramycin antibiotic resistance cassettes for use in Campylobacter jejuni. PloS one, 2014, Volume: 9, Issue:4 Topics: Arylsulfatases; Campylobacter jejuni; Drug Resistance, Microbial; Gene Deletion; Gene Transfer Techniques; Genes, Bacterial; Genetic Complementation Test; Genetic Vectors; Hygromycin B; Mutagenesis, Insertional; Nebramycin	2014
Importance of the 6'-hydroxy group and its configuration for apramycin activity. ChemMedChem, 2014, Volume: 9, Issue:9 Topics: Animals; Anti-Bacterial Agents; Bacteria; Carbohydrate Sequence; Catalytic Domain; Cell-Free System; Molecular Sequence Data; Nebramycin; Protein Biosynthesis; Protein Synthesis Inhibitors; Rabbits; Ribosomes; Structure-Activity Relationship	2014
In vivo efficacy of apramycin in murine infection models. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11 Topics: Amikacin; Animals; Anti-Bacterial Agents; Female; Interferon-gamma; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Knockout; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nebramycin; Neutropenia; Staphylococcal Infections; Tuberculosis, Pulmonary	2014
Predicting the long-term toxicity of five-antibiotic mixtures to Vibrio qinghaiensis sp. Q67. Pakistan journal of pharmaceutical sciences, 2014, Volume: 27, Issue:5 Suppl Topics: Anti-Bacterial Agents; Chloramphenicol; Nebramycin; Paromomycin; Streptomycin; Tetracycline; Vibrio	2014
A type 2 A/C2 plasmid carrying the aacC4 apramycin resistance gene and the erm(42) erythromycin resistance gene recovered from two Salmonella enterica serovars. The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:4 Topics: Animals; Anti-Bacterial Agents; DNA Helicases; Drug Resistance, Bacterial; Erythromycin; Evolution, Molecular; Genes, Bacterial; Genome, Bacterial; Molecular Sequence Data; Nebramycin; Plasmids; Salmonella enterica; Salmonella Infections, Animal; Sequence Analysis, DNA; Swine; Swine Diseases	2015
A sensitive non-derivatization method for apramycin and impurities analysis using hydrophilic interaction liquid chromatography and charged aerosol detection. Talanta, 2016, Volume: 146 Topics: Aerosols; Analytic Sample Preparation Methods; Chromatography, Liquid; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Nebramycin	2016
Apramycin treatment affects selection and spread of a multidrug-resistant Escherichia coli strain able to colonize the human gut in the intestinal microbiota of pigs. Veterinary research, 2016, Jan-07, Volume: 47 Topics: Animals; Anti-Bacterial Agents; Bacterial Shedding; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Feces; Female; Humans; Intestines; Male; Nebramycin; Selection, Genetic; Swine; Swine Diseases; Time Factors; Zoonoses	2016
Oncogenic MicroRNAs Biogenesis as a Drug Target: Structure-Activity Relationship Studies on New Aminoglycoside Conjugates. Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Apr-04, Volume: 22, Issue:15 Topics: Aminoglycosides; Biological Evolution; Drug Delivery Systems; Humans; MicroRNAs; Models, Molecular; Nebramycin; Neomycin; Stomach Neoplasms; Structure-Activity Relationship	2016
Characterization of a C3 Deoxygenation Pathway Reveals a Key Branch Point in Aminoglycoside Biosynthesis. Journal of the American Chemical Society, 2016, 05-25, Volume: 138, Issue:20 Topics: Aminoglycosides; Carbohydrate Sequence; Catalysis; Nebramycin; Oxidoreductases; Oxygen; Substrate Specificity	2016
Analysis of 76 veterinary pharmaceuticals from 13 classes including aminoglycosides in bovine muscle by hydrophilic interaction liquid chromatography-tandem mass spectrometry. Journal of chromatography. A, 2016, Jun-24, Volume: 1452 Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Bromhexine; Calibration; Cattle; Chromatography, Liquid; Drug Residues; Hydrophobic and Hydrophilic Interactions; Kanamycin; Muscles; Nebramycin; Pyrans; Solid Phase Extraction; Tandem Mass Spectrometry; Veterinary Drugs	2016
Substrate specificity of radical S-adenosyl-l-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3'-deoxygenation of aminoglycoside antibiotics. The Journal of antibiotics, 2017, Volume: 70, Issue:4 Topics: Actinobacteria; Aminoglycosides; Anti-Bacterial Agents; Hydro-Lyases; Kanamycin; NADP; Nebramycin; Substrate Specificity	2017
Evaluation of apramycin activity against carbapenem-resistant and -susceptible strains of Enterobacteriaceae. Diagnostic microbiology and infectious disease, 2016, Volume: 86, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Microbial Sensitivity Tests; Nebramycin	2016
YmdB-mediated down-regulation of sucA inhibits biofilm formation and induces apramycin susceptibility in Escherichia coli. Biochemical and biophysical research communications, 2017, 01-29, Volume: 483, Issue:1 Topics: Biofilms; Carrier Proteins; Down-Regulation; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Ketoglutarate Dehydrogenase Complex; Microbial Sensitivity Tests; Nebramycin; Ribonuclease III	2017
Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs. PloS one, 2017, Volume: 12, Issue:4 Topics: Administration, Oral; Amoxicillin; Animals; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Nebramycin; Swine	2017
Stress-responsively modulated ymdAB-clsC operon plays a role in biofilm formation and apramycin susceptibility in Escherichia coli. FEMS microbiology letters, 2017, 07-06, Volume: 364, Issue:13 Topics: Anti-Bacterial Agents; Biofilms; Carrier Proteins; Cold-Shock Response; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Microbial Sensitivity Tests; Nebramycin; Operon; Promoter Regions, Genetic; Transcription, Genetic	2017
Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues: Importance of the Configuration at the 6'-Position and Differences between the 6'-Amino and Hydroxy Series. Journal of the American Chemical Society, 2017, 10-18, Volume: 139, Issue:41 Topics: Anti-Bacterial Agents; Nebramycin; Neomycin; Paromomycin; Ribosomes	2017
In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii. The Journal of antimicrobial chemotherapy, 2019, 04-01, Volume: 74, Issue:4 Topics: Acinetobacter baumannii; Acinetobacter Infections; Africa; Aminoglycosides; Anti-Bacterial Agents; Asia; Carbapenems; Drug Resistance, Bacterial; Enterobacteriaceae; Enterobacteriaceae Infections; Europe; Genotype; Humans; Microbial Sensitivity Tests; Nebramycin; South America; Whole Genome Sequencing	2019
Evaluation of apramycin against spectinomycin-resistant and -susceptible strains of Neisseria gonorrhoeae. The Journal of antimicrobial chemotherapy, 2019, 05-01, Volume: 74, Issue:5 Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Gonorrhea; Humans; Microbial Sensitivity Tests; Nebramycin; Neisseria gonorrhoeae; Spectinomycin	2019
Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Scientific reports, 2019, 02-20, Volume: 9, Issue:1 Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cell Line; Drug Resistance, Bacterial; Gentamicins; Guinea Pigs; Hair Cells, Auditory, Inner; Hearing Loss; Humans; Nebramycin; Neomycin; Ototoxicity; Protein Synthesis Inhibitors; Round Window, Ear	2019
Adsorptive removal of apramycin antibiotic from aqueous solutions using Tween 80-and Triton X-100 modified clinoptilolite: experimental and fixed-bed modeling investigations. International journal of environmental health research, 2020, Volume: 30, Issue:5 Topics: Adsorption; Anti-Bacterial Agents; Models, Theoretical; Nebramycin; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Water Purification; Zeolites	2020
Simple spectrofluorimetric methods for determination of veterinary antibiotic drug (apramycin sulfate) in pharmaceutical preparations and milk samples. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2020, Jan-05, Volume: 224 Topics: Animals; Drug Residues; Hydrogen-Ion Concentration; Limit of Detection; Linear Models; Milk; Nebramycin; Reproducibility of Results; Spectrometry, Fluorescence; Veterinary Drugs	2020
Tentative epidemiologic cut-off value and resistant characteristic detection of apramycin against Escherichia coli from chickens. FEMS microbiology letters, 2019, 08-01, Volume: 366, Issue:16 Topics: Animals; Anti-Bacterial Agents; Chickens; China; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Genes, Bacterial; Microbial Sensitivity Tests; Nebramycin; Poultry Diseases	2019
Apralogs: Apramycin 5- Journal of the American Chemical Society, 2020, 01-08, Volume: 142, Issue:1 Topics: Aminoacyltransferases; Anti-Bacterial Agents; Carbohydrate Conformation; Carbohydrate Sequence; Drug Resistance, Bacterial; Ethers; Glycosides; Microbial Sensitivity Tests; Nebramycin	2020
Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics. Journal of the American Chemical Society, 2020, 02-12, Volume: 142, Issue:6 Topics: Anti-Bacterial Agents; Cell Membrane Permeability; Gentamicins; Hair Cells, Auditory; Humans; Mitochondria; Molecular Dynamics Simulation; Nebramycin; Proteins; Ribosomes	2020
Multifunctional SEVA shuttle vectors for actinomycetes and Gram-negative bacteria. MicrobiologyOpen, 2020, Volume: 9, Issue:6 Topics: Anti-Bacterial Agents; Apigenin; Bioreactors; Drug Resistance, Bacterial; Escherichia coli; Genetic Engineering; Genetic Vectors; Nebramycin; Plasmids; Replication Origin; Streptomyces	2020
Wild-type cutoff for Apramycin against Escherichia coli. BMC veterinary research, 2020, Aug-26, Volume: 16, Issue:1 Topics: Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Microbial Sensitivity Tests; Nebramycin; Swine; Swine Diseases	2020
Epidemiologic, Phenotypic, and Structural Characterization of Aminoglycoside-Resistance Gene International journal of molecular sciences, 2020, Aug-25, Volume: 21, Issue:17 Topics: Acetyltransferases; Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Carbapenems; Catalytic Domain; Databases, Genetic; Drug Resistance, Bacterial; Genome, Bacterial; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Methyltransferases; Molecular Epidemiology; Mutagenesis, Site-Directed; Nebramycin; Standard of Care; Structure-Activity Relationship	2020
An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity. ChemMedChem, 2021, 01-19, Volume: 16, Issue:2 Topics: Animals; Anti-Bacterial Agents; Carbohydrate Conformation; Cochlea; Escherichia coli; Mice; Microbial Sensitivity Tests; Nebramycin	2021
NaCl Concentration-Dependent Aminoglycoside Resistance of Journal of microbiology and biotechnology, 2021, Feb-28, Volume: 31, Issue:2 Topics: Aminoglycosides; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Gentamicins; Halomonas; Kanamycin; Kanamycin Kinase; Nebramycin; Sodium Chloride	2021
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin. Clinical pharmacology and therapeutics, 2021, Volume: 109, Issue:4 Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Bacteriological Techniques; Dogs; Dose-Response Relationship, Drug; Escherichia coli; Guinea Pigs; Mice; Models, Biological; Nebramycin; Rats	2021
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2021, Volume: 27, Issue:9 Topics: Acinetobacter baumannii; Acinetobacter Infections; Aminoglycosides; Animals; Anti-Bacterial Agents; Colistin; Lung; Mice; Microbial Sensitivity Tests; Nebramycin	2021
Research Note: Epidemiological cutoff values and acquired resistance mechanisms of three veterinary antibiotics against Escherichia coli from chicken respiratory tract infections. Poultry science, 2021, Volume: 100, Issue:2 Topics: Animals; Anti-Bacterial Agents; Chickens; China; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Fluoroquinolones; Microbial Sensitivity Tests; Nebramycin; Poultry Diseases; Respiratory Tract Infections; Thiamphenicol	2021
Pivotal Role of Translation in Anti-Infective Development. Clinical pharmacology and therapeutics, 2021, Volume: 109, Issue:4 Topics: Aminoglycosides; Anti-Infective Agents; Antiviral Agents; Carbapenems; Dose-Response Relationship, Drug; Drug Approval; Drug Development; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Models, Biological; Nebramycin; Research Design; United States; United States Food and Drug Administration	2021
Two Cryptic Self-Resistance Mechanisms in Streptomyces tenebrarius Reveal Insights into the Biosynthesis of Apramycin. Angewandte Chemie (International ed. in English), 2021, 04-12, Volume: 60, Issue:16 Topics: Actinobacteria; Anti-Bacterial Agents; Nebramycin	2021
ApmA Is a Unique Aminoglycoside Antibiotic Acetyltransferase That Inactivates Apramycin. mBio, 2021, 02-09, Volume: 12, Issue:1 Topics: Acetylation; Acetyltransferases; Aminoglycosides; Anti-Bacterial Agents; Crystallization; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Humans; Microbial Sensitivity Tests; Nebramycin	2021
Translation error clusters induced by aminoglycoside antibiotics. Nature communications, 2021, 03-23, Volume: 12, Issue:1 Topics: Aminoglycosides; Anti-Bacterial Agents; Escherichia coli; Mass Spectrometry; Mutation, Missense; Nebramycin; Peptide Elongation Factor Tu; Peptides; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteome; Proteomics; Recombinant Proteins; Ribosomes; Streptomycin; Stress, Physiological	2021
Apramycin resistance in epidemic carbapenem-resistant Klebsiella pneumoniae ST258 strains. The Journal of antimicrobial chemotherapy, 2021, 07-15, Volume: 76, Issue:8 Topics: Anti-Bacterial Agents; Carbapenems; Epidemics; Humans; Klebsiella Infections; Klebsiella pneumoniae; Multilocus Sequence Typing; Nebramycin	2021
Proposal of Epidemiological Cutoff Values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Microbial drug resistance (Larchmont, N.Y.), 2021, Volume: 27, Issue:11 Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Nebramycin; Staphylococcus aureus; Thiamphenicol; Veterinary Medicine	2021
Engineering of Molecules (Basel, Switzerland), 2021, Jul-18, Volume: 26, Issue:14 Topics: Actinobacteria; Aminoglycosides; Anti-Bacterial Agents; Fermentation; Genetic Engineering; Multigene Family; Nebramycin; Tobramycin	2021
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis. EBioMedicine, 2021, Volume: 73 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Humans; Hydrogen-Ion Concentration; Mice; Microbial Sensitivity Tests; Nebramycin; Pyelonephritis; Rats; Treatment Outcome; Urinary Tract Infections	2021
Apramycin Overcomes the Inherent Lack of Antimicrobial Bactericidal Activity in Mycobacterium abscessus. Antimicrobial agents and chemotherapy, 2022, 02-15, Volume: 66, Issue:2 Topics: Animals; Anti-Bacterial Agents; Mice; Microbial Sensitivity Tests; Mycobacterium abscessus; Mycobacterium Infections, Nontuberculous; Nebramycin	2022
Characterization and utilization of methyltransferase for apramycin production in Streptoalloteichus tenebrarius. Journal of industrial microbiology & biotechnology, 2022, Jul-30, Volume: 49, Issue:4 Topics: Actinobacteria; Actinomycetales; Aminoglycosides; Anti-Bacterial Agents; Escherichia coli; Methyltransferases; Nebramycin; Streptomyces; Tobramycin	2022
Apramycin susceptibility of multidrug-resistant Gram-negative blood culture isolates in five countries in Southeast Asia. International journal of antimicrobial agents, 2022, Volume: 60, Issue:4 Topics: Amikacin; Aminoglycosides; Anti-Bacterial Agents; Asia, Southeastern; Blood Culture; Carbapenems; Cephalosporins; Colistin; Drug Resistance, Multiple, Bacterial; Gentamicins; Gram-Negative Bacteria; Microbial Sensitivity Tests; Nebramycin; Pseudomonas aeruginosa; Tobramycin	2022
Importance of Co-operative Hydrogen Bonding in the Apramycin-Ribosomal Decoding A-Site Interaction. ChemMedChem, 2023, 01-03, Volume: 18, Issue:1 Topics: Aminoglycosides; Anti-Bacterial Agents; Hydrogen Bonding; Nebramycin; Ribosomes	2023
Biosynthetic Origin of the Octose Core and Its Mechanism of Assembly during Apramycin Biosynthesis. Journal of the American Chemical Society, 2023, 10-04, Volume: 145, Issue:39 Topics: Aminoglycosides; Anti-Bacterial Agents; Carbon; Nebramycin	2023