toborinone has been researched along with carbostyril in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 27 (79.41) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujiki, H; Hosokawa, T; Imaizumi, T; Kinoshita, S; Mori, T; Noda, T; Ohura, M; Takemoto, K; Tominaga, M; Yabuuchi, Y | 1 |
| Fujioka, T; Hosokawa, T; Mori, T; Sumida, T; Teramoto, S; Tominaga, M; Yabuuchi, Y | 1 |
| Endoh, M; Katano, Y; Kawabata, Y; Norota, I | 1 |
| Fujiki, H; Ishikawa, M; Itoh, S; Koga, K; Mori, T; Tominaga, M; Yabuuchi, Y | 1 |
| Ishikawa, M; Itoh, S; Koga, K; Mori, T; Tominaga, M; Yabuuchi, Y | 1 |
| Bhat, G; Burwig, S; Eppert, D; Hoit, BD; Walsh, RA | 1 |
| Kitani, M; Miyamoto, G; Odomi, M | 1 |
| Abe, H; Awaji, T; Hashimoto, K; Motomura, S; Wu, Z | 1 |
| Fujita, T; Hirayama, A; Kitani, M; Kodama, K; Mishima, M; Miyamoto, G; Ohnishi, A; Ohno, T; Takeshige, Y; Toyoki, T | 1 |
| Feldman, AM; Strobeck, JE | 1 |
| Bergin, JD; Cowart, TD; Feldman, AM; Feldman, MD; Haber, HL; Heesch, CM; Johnson, W; Kass, DA; Pak, PH; Powers, ER; Wu, CC | 1 |
| Fujiki, H; Itoh, S; Mori, T; Tominaga, M; Yabuuchi, Y; Yoshida, K | 1 |
| Ishihara, H; Kanda, H; Kato, R; Nagata, K; Sobue, T; Yokota, M | 1 |
| Fujiki, H; Iijima, T; Mori, T; Orito, K; Sekiguchi, K; Takase, H; Tominaga, M | 1 |
| Fujioka, T; Hosokawa, T; Mori, T; Sumida, T; Takemoto, K; Teramoto, S; Tominaga, M; Tsujimi, S; Yabuuchi, Y | 1 |
| Fujiki, H; Mori, T; Orito, K; Takase, H | 1 |
| Fujiki, H; Imaizumi, T; Mori, T; Tominaga, M; Yoshida, K | 1 |
| Fujiki, H; Itoh, S; Mori, T; Tominaga, M | 1 |
| Ishihara, H; Iwase, M; Machii, T; Nagata, K; Sobue, T; Yokota, M | 1 |
| Roden, DM; Snyders, DJ; Yang, T | 1 |
| Kitani, M; Matsubara, J; Miyamoto, G; Nagasawa, M; Odomi, M; Uchida, M; Yamada, T | 1 |
| Bito, H; Kadotani, H; Kato, N; Maruyama, K; Ogawa, R | 1 |
| Fujiki, H; Ishikawa, M; Koga, K; Mori, T; Yabuuchi, Y | 1 |
| Abraham, WT; Bristow, MR; Ferguson, DA; Lindenfeld, J; Lowes, BD; Scheffel, CA; White, M; Wolfel, EE | 1 |
| Cowart, TD; Feldman, MD; Haber, HL; MacGowan, GA; Tedesco, C; Wu, C | 1 |
| Belenkie, I; Semeniuk, LM; Tyberg, JV | 1 |
| Akamatsu, T; Hirata, T; Horinokuchi, N; Kuro, M; Uchida, O | 1 |
| MacGowan, GA | 1 |
| Hashimoto, K; Satoh, Y; Sugiyama, A | 1 |
| Fujiki, H; Izumoto, H; Kawazoe, K | 1 |
| Bramer, SL; Brisson, J; Kitani, M; Miyamoto, G; Tammara, B; Trang, JM | 1 |
| Young, JB | 1 |
| Bramer, SL; Kitani, M; Miyamoto, G; Tammara, B; Trang, JM | 1 |
| Aoki, H; Hiramatsu, N; Kageyama, K; Mizobe, T; Nakajima, Y; Nozuchi, S | 1 |
3 review(s) available for toborinone and carbostyril
| Article | Year |
|---|---|
Quinolinone derivatives in the management of congestive heart failure.
Topics: Animals; Cardiotonic Agents; Heart Failure; Humans; Pyrazines; Quinolines; Quinolones | 1994 |
Clinical overview of the novel inotropic agent toborinone.
Topics: Animals; Cardiotonic Agents; Heart Failure; Hemodynamics; Humans; Quinolones | 2000 |
New therapeutic choices in the management of acute congestive heart failure.
Topics: Acute Disease; Heart Failure; Humans; Hydrazones; Milrinone; Natriuretic Agents; Natriuretic Peptide, Brain; Pyridazines; Quinolones; Simendan; Treatment Outcome; Vasodilator Agents | 2001 |
9 trial(s) available for toborinone and carbostyril
| Article | Year |
|---|---|
Effects of a novel inotropic agent (OPC-18790) on systolic and diastolic function in patients with severe heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Diastole; Double-Blind Method; Echocardiography; Female; Heart Atria; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Pulmonary Wedge Pressure; Quinolones; Radionuclide Ventriculography; Stroke Volume; Systole; Ventricular Function, Left | 1994 |
Pharmacokinetics and pharmacodynamics of intravenous OPC-18790 in humans: a novel nonglycosidic inotropic agent.
Topics: Adult; Cardiotonic Agents; Echocardiography; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Quinolones; Ventricular Function, Left | 1994 |
Acute cardiovascular effects of OPC-18790 in patients with congestive heart failure. Time- and dose-dependence analysis based on pressure-volume relations.
Topics: Blood Pressure; Cardiomyopathy, Dilated; Cardiotonic Agents; Heart Rate; Humans; Quinolones; Stroke Volume | 1996 |
A novel inotropic vasodilator, OPC-18790, reduces myocardial oxygen consumption and improves mechanical efficiency with congestive heart failure.
Topics: Cardiotonic Agents; Dobutamine; Heart; Heart Failure; Hemodynamics; Humans; Middle Aged; Oxygen Consumption; Prospective Studies; Quinolones; Vascular Resistance; Vasodilator Agents; Ventricular Function, Left | 1996 |
Effect of dobutamine and OPC-18790 on diastolic chamber stiffness in patients with idiopathic dilated cardiomyopathy.
Topics: Adult; Aged; Cardiomyopathy, Dilated; Cardiotonic Agents; Diastole; Dobutamine; Female; Humans; Male; Middle Aged; Quinolones; Ventricular Function, Left | 1997 |
[Effects of toborinone on systemic circulation in patients under general anesthesia].
Topics: Adult; Aged; Anesthesia, General; Cardiotonic Agents; Female; Hemodynamics; Humans; Infusions, Intravenous; Intraoperative Care; Male; Middle Aged; Quinolones | 1997 |
Study on the effectiveness of toborinone (OPC-18790) in the treatment of heart failure in patients following cardiac surgery.
Topics: Aged; Cardiac Surgical Procedures; Cardiotonic Agents; Extracorporeal Circulation; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Postoperative Complications; Quinolones | 1999 |
The effects of concomitant administration of theophylline and toborinone on the pharmacokinetics of both compounds in poor and extensive metabolizers via CYP2D6.
Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Drug Interactions; Humans; Quinolones; Theophylline; Vasodilator Agents | 2002 |
The pharmacokinetics of toborinone in subjects with congestive heart failure and concomitant renal impairment and/or concomitant hepatic impairment.
Topics: Adult; Aged; Cardiotonic Agents; Chromatography, High Pressure Liquid; Female; Heart Failure; Humans; Indicators and Reagents; Infusions, Intravenous; Kidney Diseases; Kidney Function Tests; Liver Diseases; Liver Function Tests; Male; Middle Aged; Quinolones; Reproducibility of Results; Time Factors | 2002 |
22 other study(ies) available for toborinone and carbostyril
| Article | Year |
|---|---|
Cardiovascular actions of OPC-18790: a novel positive inotropic agent with little chronotropic action.
Topics: Animals; Atrioventricular Node; Cardiotonic Agents; Cats; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Guinea Pigs; Heart Ventricles; Hemodynamics; Male; Models, Cardiovascular; Myocardial Contraction; Papillary Muscles; Quinolones; Rabbits; Sinoatrial Node | 1992 |
Novel positive inotropic agents: synthesis and biological activities of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinone derivatives.
Topics: Animals; Cardiotonic Agents; Dogs; Female; Hemodynamics; Male; Quinolones; Structure-Activity Relationship | 1992 |
Effects of a novel cardiotonic agent (+-)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolino ne (OPC-18790) on contractile force, cyclic AMP level, and aequorin light transients in dog ventricular myocardium.
Topics: Aequorin; Animals; Calcium; Carbachol; Cardiotonic Agents; Cyclic AMP; Dogs; Electrophysiology; Female; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Quinolones; Stimulation, Chemical | 1994 |
Effects of OPC-18790, a new positive inotropic agent, on energetics in the ischaemic canine heart: a 31P-MRS study.
Topics: Amrinone; Animals; Blood Pressure; Cardiotonic Agents; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Energy Metabolism; Female; Heart Rate; Magnetic Resonance Imaging; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Quinolones | 1995 |
Differential effects of OPC-18790, amrinone and dobutamine on cardiac function and energy metabolism in the guinea-pig isolated ischaemic heart.
Topics: Adenosine Triphosphate; Amrinone; Animals; Cardiac Pacing, Artificial; Cardiotonic Agents; Coronary Circulation; Dobutamine; Energy Metabolism; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Ischemia; Phosphocreatine; Quinolones; Ventricular Function, Left | 1995 |
Stereoselective high-performance liquid chromatographic assay for the determination of OPC-18790 enantiomers in human plasma and urine.
Topics: Cardiotonic Agents; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Molecular Structure; Quinolones; Solvents; Stereoisomerism | 1993 |
Effects of OPC-18790, a new positive inotropic agent, on canine ventricular arrhythmias.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Coronary Circulation; Disease Models, Animal; Dogs; Epinephrine; Female; Heart Rate; Male; Myocardial Contraction; Myocardial Ischemia; Ouabain; Quinolones; Tachycardia, Ventricular; Vasodilation; Ventricular Fibrillation | 1993 |
Cardiovascular effects of the combination of OPC-18790 and dopamine in halothane-anesthetized dogs.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Dogs; Dopamine; Drug Combinations; Female; Halothane; Heart Rate; Male; Quinolones; Time Factors | 1995 |
Positive inotropic and chronotropic effects of toborinone and its electrophysiological properties in the isolated hearts of rabbits and guinea-pigs.
Topics: Action Potentials; Animals; Cardiotonic Agents; Cyclic AMP; Electrophysiology; Guinea Pigs; Heart; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Muscle Contraction; Myocardial Contraction; Patch-Clamp Techniques; Quinolones; Rabbits | 1996 |
Synthesis and biological activities of optically active 6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone (OPC-18790).
Topics: Animals; Cardiotonic Agents; Dogs; In Vitro Techniques; Myocardial Contraction; Quinolones; Stereoisomerism | 1996 |
Effects of toborinone (OPC-18790), a new positive inotropic agent, on action potential in guinea pig sinoatrial node: compared with milrinone and E-4031.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Cardiotonic Agents; Electrophysiology; Guinea Pigs; Male; Milrinone; Phosphodiesterase Inhibitors; Piperidines; Pyridines; Pyridones; Quinolones; Sinoatrial Node | 1996 |
OPC-18790, a novel positive inotropic agent, has both arterial and venous vascular dilating actions in the dog.
Topics: Animals; Autonomic Denervation; Blood Pressure; Cardiac Output; Cardiotonic Agents; Dogs; Female; Heart; Heart Rate; Male; Microspheres; Quinolones; Vascular Resistance; Vasodilator Agents | 1996 |
Effects of toborinone on myocardial oxygen consumption in pacing-induced heart failure dogs.
Topics: Animals; Cardiac Pacing, Artificial; Cardiotonic Agents; Dogs; Female; Heart; Heart Failure; Hemodynamics; Male; Myocardial Contraction; Myocardium; Oxygen Consumption; Quinolones; Ventricular Function, Left | 1996 |
Inhibition of cardiac potassium currents by the vesnarinone analog OPC-18790: comparison with quinidine and dofetilide.
Topics: Animals; Cardiotonic Agents; Female; L Cells; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenethylamines; Potassium Channel Blockers; Quinidine; Quinolones; Recombinant Proteins; Sulfonamides | 1997 |
Biotransformation of the novel inotropic agent toborinone (OPC-18790) in rats and dogs. Evidence for the formation of novel glutathione and two cysteine conjugates.
Topics: Animals; Biotransformation; Cardiotonic Agents; Cysteine; Dogs; Feces; Glutathione; Male; Mass Spectrometry; Quinolones; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1997 |
Comparative study of toborinone (OPC-18790) and milrinone on energy metabolism in microembolized guinea pig hearts.
Topics: Animals; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Heart; Male; Milrinone; Myocardial Ischemia; Pyridones; Quinolones | 1997 |
Comparative hemodynamic effects of OPC-18790 and dobutamine in patients with advanced heart failure.
Topics: Adrenergic beta-Antagonists; Aged; Cardiotonic Agents; Dobutamine; Female; Heart; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Quinolones; Ventricular Function, Left | 1994 |
Direct myocardial effects of OPC-18790 in human heart failure: beneficial effects on contractile and diastolic function demonstrated by intracoronary infusion with pressure-volume analysis.
Topics: Aged; Cardiac Catheterization; Cardiotonic Agents; Diastole; Heart; Heart Failure; Heart Rate; Hemodynamics; Humans; Infusions, Intravenous; Middle Aged; Myocardial Contraction; Quinolones; Systole; Treatment Outcome; Ventricular Function | 1998 |
Acute effects of toborinone on vascular capacitance and conductance in experimental heart failure.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dogs; Enalaprilat; Female; Heart Failure; Hemodynamics; Hydralazine; Male; Nitroglycerin; Phosphodiesterase Inhibitors; Quinolones; Vascular Capacitance; Vasodilator Agents | 1998 |
Electropharmacologic effects of a new phosphodiesterase III inhibitor, toborinone (OPC-18790), assessed in an in vivo canine model.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Blood Pressure; Cardiotonic Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Dogs; Electrocardiography; Electrophysiologic Techniques, Cardiac; Female; Heart Rate; Hemodynamics; Male; Phosphodiesterase Inhibitors; Quinolones; Ventricular Function | 2001 |
Vascular relaxant effects of toborinone on the isolated canine internal mammary artery.
Topics: Animals; Dogs; Mammary Arteries; Quinolones; Vasodilation; Vasodilator Agents | 2001 |
Toborinone and olprinone, phosphodiesterase III inhibitors, inhibit human platelet aggregation due to the inhibition of both calcium release from intracellular stores and calcium entry.
Topics: Blood Platelets; Calcium; Cyclic AMP; Humans; Imidazoles; In Vitro Techniques; Intracellular Space; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridones; Quinolones; Thrombin | 2004 |