tixocortol-pivalate and nickel-sulfate

There have been few studies regarding the results of the Korean standard patch test.. The purpose of this study was to analyze the type and frequency of common contact allergens in Korea and to compare the results with those of previous reports.. From June 2009 to June 2014, 330 patients with suspected allergic contact dermatitis who visited our clinic were tested using the Korean standard patch test.. The highest sensitization rate was found for nickel sulfate (47.58%). There was a significant gender difference in the prevalence of sensitization to nickel sulfate (OR = 2.41, p = .0004) and wool alcohol (OR = 2.85, p = .0358). Higher sensitization to nickel sulfate (OR = 1.18, p = .0159), 4-phenylenediamine (OR = 1.23, p= .003), tixocortol-21-pivalte (OR 1.48, p = .0212) and lower sensitization to thimerosal (OR = 0.77, p = .0023) were associated with increasing age. Patients with allergic contact dermatitis on the scalp had a significantly higher risk of sensitization to 4-phenylenediamine (OR = 3.07, p = .0013). Patients with allergic contact dermatitis on the hands had significantly higher risks of sensitization to wool alcohol (OR = 3.44, p = .0083), formaldehyde (OR = 2.52, p = .0178), and colophony (OR = 2.05, p = .0499).. These results demonstrate trends in patch test results in Korea and the basis for the presumption of the route of allergen exposure.

Topics: Allergens; Dermatitis, Allergic Contact; Humans; Hydrocortisone; Nickel; Odds Ratio; Patch Tests; Phenylenediamines; Prevalence; Republic of Korea; Sex Factors

We have studied, immunohistochemically, hypersensitivity reactions to corticosteroids and compared them with allergic contact dermatitis from nickel and appropriate controls. We could find no qualitative differences between nickel and corticosteroid contact reactions, providing further evidence that hypersensitivity to corticosteroids is an immunologically mediated reaction.

Topics: Administration, Topical; Anti-Inflammatory Agents; Cell Adhesion Molecules; Dermatitis, Allergic Contact; E-Selectin; Endothelium; Gene Expression; Humans; Hydrocortisone; Immunohistochemistry; Intercellular Adhesion Molecule-1; Irritants; Keratinocytes; Lymphocytes; Membrane Glycoproteins; Nickel; Receptors, Immunologic