titanocene has been researched along with carbene* in 1 studies
1 other study(ies) available for titanocene and carbene
| Article | Year |
|---|---|
Preparation of Titanocene-Gold Compounds Based on Highly Active Gold(I)-N-Heterocyclic Carbene Anticancer Agents: Preliminary in vitro Studies in Renal and Prostate Cancer Cell Lines.
Heterometallic titanocene-based compounds containing gold(I)-phosphane fragments have been extremely successful against renal cancer in vitro and in vivo. The exchange of phosphane by N-heterocyclic carbene ligands to improve or modulate their pharmacological profile afforded bimetallic complexes effective against prostate cancer, but less effective against renal cancer in vitro. Herein we report the synthesis of new bimetallic Ti-Au compounds by the incorporation of two previously reported highly active gold(I)-N-heterocyclic carbene fragments derived from 4,5-diarylimidazoles. The two new compounds [(η Topics: Antineoplastic Agents; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Coordination Complexes; Density Functional Theory; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gold; Heterocyclic Compounds; Humans; Methane; Molecular Structure; Organometallic Compounds; Structure-Activity Relationship | 2019 |