tirucallane and ursane

Extensive phytochemical investigation on the whole herbs of Euphorbia hypericifolia led to the isolation of 18 structurally diverse tetracyclic and pentacyclic triterpenoids, including four 4α,14α-dimethyl-5α-ergostanes (1-4), two seco-adiananes (5 and 6), three dammaranes (7-9), four cycloartanes (10-13), one tirucallane (14), two fernanes (15 and 16), one ursane (17), and one oleanane (18). Among them, euphypenoids A (1) and B (5) were new triterpenoids. Their structures were elucidated on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction, and chemical transformation. All isolates were screened for their cytotoxic activities against the colorectal cancer cell line HCT-116, and compounds 1, 12, and 15 showed remarkable activities with IC

Topics: Antineoplastic Agents, Phytogenic; China; Dammaranes; Euphorbia; HCT116 Cells; Humans; Molecular Structure; Phytochemicals; Triterpenes

Two new ursane-type triterpenes characterized as 3-oxo-24-acetoxy-11α-hydroxy-urs-12-ene (1) and methyl 3α-acetoxy-11α-methoxy-urs-12-en-24-oate (2), together with known compounds 3-11, were isolated from Boswellia rivae oleo-gum resin exudate. Their structural elucidation was accomplished using physical, chemical, and spectroscopic methods. The compounds exhibited weak to moderate antibacterial activities against some Gram-positive and Gram-negative bacteria.

Topics: Anti-Bacterial Agents; Boswellia; Electron Spin Resonance Spectroscopy; Gram-Negative Bacteria; Gram-Positive Bacteria; Kenya; Microbial Sensitivity Tests; Molecular Structure; Resins, Plant; Triterpenes