tirapazamine has been researched along with cinnoline* in 1 studies
1 other study(ies) available for tirapazamine and cinnoline
| Article | Year |
|---|---|
Quinoxalino[2,3-c]cinnolines and their 5-N-oxide: alkoxylation of methyl-substituted quinoxalino[2,3-c]cinnolines to acetals and orthoesters.
We report the alkoxylation of methyl-substituted quinoxalino[2,3-c]cinnolines to give acetals and orthoesters in high yields. Routes to the precursors of this alkoxylation reaction as well as other quinoxalino[2,3-c]cinnoline and their 5-oxide derivatives are reported. Most of these quinoxalino[2,3-c]cinnolines were prepared by cyclization of the corresponding 2-amino-3-(2-nitrophenyl)quinoxaline, which, in turn, result from an unusual Beirut reaction from benzofurazan oxides plus 2-nitrobenzylcyanides. Mechanistic explanations for these intriguing reactions are presented. Topics: Acetals; Alcohols; Antineoplastic Agents; Benzoxazoles; Chemistry, Pharmaceutical; Cyanides; Cyclization; Esters; Heterocyclic Compounds, 2-Ring; Humans; Magnetic Resonance Spectroscopy; Neoplasms; Oxides; Quinoxalines; Tirapazamine; Triazines | 2011 |