tirandamycin-a has been researched along with tirandalydigin* in 3 studies
1 review(s) available for tirandamycin-a and tirandalydigin
| Article | Year |
|---|---|
[Stereocontrolled Total Synthesis of Biologically Active Natural Products].
　This review article describes the total syntheses of englerin A, ophiodilactones A and B, marinomycin A, N-methylwelwitindolinone C isothiocyanate, tirandamycins A-D, and tirandalydigin, which possess intriguing biological activities and challenging structures with characteristic ring systems. The focus is on the synthetic methodologies that lead to the highly stereocontrolled assembly of these natural products. Topics: Alkenes; Aminoglycosides; Benzene Derivatives; Biological Products; Indole Alkaloids; Lactones; Macrolides; Molecular Conformation; Sesquiterpenes, Guaiane; Stereoisomerism | 2018 |
2 other study(ies) available for tirandamycin-a and tirandalydigin
| Article | Year |
|---|---|
Unified synthesis of tirandamycins and streptolydigins.
The asymmetric total syntheses of tirandamycins A-D and tirandalydigin as well as the synthesis of the left-hand fragment of streptolydiginone and streptolydigin from a common intermediate are described. The comprehensive approach features the highly enantio- and diastereoselective assembly of the anti,anti,syn-stereotetrad unit which relies on a cinchona alkaloid-catalyzed asymmetric Morita-Baylis-Hillman reaction. Topics: Aminoglycosides; Anti-Bacterial Agents; Bridged Bicyclo Compounds, Heterocyclic; Hydrogenation; Pyrrolidinones; Stereoisomerism | 2015 |
Tirandalydigin, a novel tetramic acid of the tirandamycin-streptolydigin type. I. Taxonomy of the producing organism, fermentation and biological activity.
Tirandalydigin is a new tetramic acid antibiotic which was discovered in a screen designed to find compounds with activity against pathogenic anaerobic bacteria. It was named tirandalydigin because it possesses structural features that are common to both tirandamycin and streptolydigin. The producing culture, strain AB 1006A-9, is a Streptomyces and was compared to the streptomycetes that synthesize tirandamycin and streptolydigin. It is closely related to the former culture and was named Streptomyces tirandis subsp. umidus. Tirandalydigin has MICs in the range of 0.5 to 32 micrograms/ml against many pathogenic anaerobes, streptococci, enterococci and legionellae. Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria; Chromatography, High Pressure Liquid; Fermentation; In Vitro Techniques; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Streptomyces | 1992 |