Page last updated: 2024-09-04

tipifarnib and triazoles

tipifarnib has been researched along with triazoles in 3 studies

Compound Research Comparison

Studies
(tipifarnib)
Trials
(tipifarnib)
Recent Studies (post-2010)
(tipifarnib)
Studies
(triazoles)
Trials
(triazoles)
Recent Studies (post-2010) (triazoles)
309929425,8082,25213,501

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Angibaud, P; Bourdrez, X; End, DW; Freyne, E; Lezouret, P; Mannens, G; Mevellec, L; Meyer, C; Pilatte, I; Poncelet, V; Roux, B; Saha, AK; Smets, G; Van Dun, J; Venet, M; Wouters, W1
Bessems, A; De Porre, PM; Dodwell, DJ; Howes, AJ; Johnston, SR; Manikhas, GM; Neven, P; Park, YC; Perez Ruixo, JJ; Romieu, G; Semiglazov, VF; Spaeth, D; Wardley, AM1
Bahia, MT; Buckner, FS; Charman, SA; Chatelain, E; Chennamaneni, NK; Gelb, MH; Hulverson, MA; Laydbak, JU; Lepesheva, GI; Scandale, I; Shackleford, DM; Suryadevara, PK; Verlinde, CL; White, KL1

Trials

1 trial(s) available for tipifarnib and triazoles

ArticleYear
A phase II, randomized, blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapy.
    Breast cancer research and treatment, 2008, Volume: 110, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Double-Blind Method; Estrogen Receptor Modulators; Farnesyltranstransferase; Female; Humans; Letrozole; Middle Aged; Nitriles; Quinolones; Time Factors; Treatment Outcome; Triazoles

2008

Other Studies

2 other study(ies) available for tipifarnib and triazoles

ArticleYear
4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.
    Bioorganic & medicinal chemistry letters, 2003, Dec-15, Volume: 13, Issue:24

    Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Cell Division; Enzyme Inhibitors; Farnesyltranstransferase; Heterocyclic Compounds; Humans; Kinetics; Mice; Microsomes, Liver; Models, Molecular; Molecular Conformation; Quinolones; Structure-Activity Relationship; Triazoles

2003
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:9

    Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Alkyl and Aryl Transferases; Animals; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Female; Humans; Mice; Models, Molecular; Nitroimidazoles; Quinolones; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2012