tipifarnib has been researched along with topotecan in 2 studies
Studies (tipifarnib) | Trials (tipifarnib) | Recent Studies (post-2010) (tipifarnib) | Studies (topotecan) | Trials (topotecan) | Recent Studies (post-2010) (topotecan) |
---|---|---|---|---|---|
309 | 92 | 94 | 2,392 | 626 | 792 |
Protein | Taxonomy | tipifarnib (IC50) | topotecan (IC50) |
---|---|---|---|
Cytochrome P450 3A4 | Homo sapiens (human) | 1.5211 | |
DNA topoisomerase 1 | Homo sapiens (human) | 0.8525 | |
DNA topoisomerase 2-alpha | Homo sapiens (human) | 0.605 | |
DNA topoisomerase 2-beta | Homo sapiens (human) | 0.605 | |
Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | 0.06 | |
Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | 8.6 | |
Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | 1.3 | |
Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 0.17 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (50.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
Karp, J | 1 |
2 other study(ies) available for tipifarnib and topotecan
Article | Year |
---|---|
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Future research directions for the treatment of AML.
Topics: Antineoplastic Agents; Azacitidine; Biomedical Research; Carbazoles; Carboplatin; Cytarabine; Daunorubicin; Decitabine; Enzyme Inhibitors; Etoposide; Flavonoids; Furans; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Piperidines; Quinolones; Staurosporine; Topotecan; Tretinoin | 2008 |