Page last updated: 2024-09-04

tipifarnib and simvastatin

tipifarnib has been researched along with simvastatin in 5 studies

Compound Research Comparison

Studies
(tipifarnib)
Trials
(tipifarnib)
Recent Studies (post-2010)
(tipifarnib)
Studies
(simvastatin)
Trials
(simvastatin)
Recent Studies (post-2010) (simvastatin)
30992948,4421,7303,630

Protein Interaction Comparison

ProteinTaxonomytipifarnib (IC50)simvastatin (IC50)
photoreceptor-specific nuclear receptorHomo sapiens (human)1.164
transactivating tegument protein VP16 [Human herpesvirus 1]Human alphaherpesvirus 1 (Herpes simplex virus type 1)4.426
Bile salt export pumpHomo sapiens (human)10
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHomo sapiens (human)0.7843
ATP-dependent translocase ABCB1Homo sapiens (human)9.5
Insulin receptor Rattus norvegicus (Norway rat)0.0034
Prostaglandin G/H synthase 2Homo sapiens (human)0.0034
3-hydroxy-3-methylglutaryl-coenzyme A reductase Rattus norvegicus (Norway rat)0.0111
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)0.049
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)6.7

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Beloueche, M; Jackson, LE; Leach, MO; Ronen, SM1
de Jonge-Peeters, SD; de Vries, EG; Kuipers, F; van der Weide, K; Vellenga, E1
Busceti, MT; Caraglia, M; Falcone, D; Fratto, D; Gallelli, L; Maselli, R; Pelaia, G; Renda, T; Savino, R; Terracciano, R; Vatrella, A1
Ahmed, TA; Hayslip, J; Leggas, M1

Other Studies

5 other study(ies) available for tipifarnib and simvastatin

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells.
    British journal of cancer, 2001, Mar-02, Volume: 84, Issue:5

    Topics: 3T3 Cells; Animals; Benzoquinones; Biomarkers, Tumor; Cell Division; Cell Line, Transformed; Enzyme Inhibitors; Genes, ras; Lactams, Macrocyclic; Magnetic Resonance Spectroscopy; MAP Kinase Signaling System; Mice; Mutation; Nucleotides; Phosphorylcholine; Proto-Oncogene Proteins p21(ras); Quinolones; Rifabutin; Simvastatin; Transfection

2001
Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, May-01, Volume: 15, Issue:9

    Topics: Anticholesteremic Agents; Antigens, CD34; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Drug Therapy, Combination; Farnesyltranstransferase; Humans; Leukemia, Myeloid, Acute; Quinolones; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin

2009
Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells.
    Cell proliferation, 2012, Volume: 45, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Lung Neoplasms; MAP Kinase Signaling System; Phosphorylation; Quinolones; Simvastatin

2012
Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition.
    Leukemia research, 2014, Volume: 38, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia; Quinolones; ras Proteins; Simvastatin

2014