Page last updated: 2024-09-04

tipifarnib and pemetrexed

tipifarnib has been researched along with pemetrexed in 2 studies

Compound Research Comparison

Studies
(tipifarnib)
Trials
(tipifarnib)
Recent Studies (post-2010)
(tipifarnib)
Studies
(pemetrexed)
Trials
(pemetrexed)
Recent Studies (post-2010) (pemetrexed)
30992942,4696571,695

Protein Interaction Comparison

ProteinTaxonomytipifarnib (IC50)pemetrexed (IC50)
Thymidylate synthase Escherichia coli1.1
Dihydrofolate reductaseHomo sapiens (human)4.0309
Dihydrofolate reductaseLacticaseibacillus casei2.3
Thymidylate synthaseHomo sapiens (human)8.1787
Dihydrofolate reductaseEscherichia coli K-122.3
Folate receptor betaHomo sapiens (human)0.2585
Folate receptor alphaHomo sapiens (human)0.2417
Trifunctional purine biosynthetic protein adenosine-3Homo sapiens (human)0.0342
Bifunctional purine biosynthesis protein ATICHomo sapiens (human)0.07
Reduced folate transporterHomo sapiens (human)0.0928
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii1.655
Proton-coupled folate transporterHomo sapiens (human)0.0229

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Heinemann, V1

Reviews

1 review(s) available for tipifarnib and pemetrexed

ArticleYear
Gemcitabine in the treatment of advanced pancreatic cancer: a comparative analysis of randomized trials.
    Seminars in oncology, 2002, Volume: 29, Issue:6 Suppl 20

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Camptothecin; Capecitabine; Cisplatin; Deoxycytidine; Docetaxel; Fluorouracil; Gemcitabine; Glutamates; Guanine; Humans; Hydroxamic Acids; Irinotecan; Organic Chemicals; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Pancreatic Neoplasms; Pemetrexed; Phenylbutyrates; Quinolones; Randomized Controlled Trials as Topic; Taxoids

2002

Other Studies

1 other study(ies) available for tipifarnib and pemetrexed

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013