Page last updated: 2024-09-04

tipifarnib and manumycin

tipifarnib has been researched along with manumycin in 3 studies

Compound Research Comparison

Studies (tipifarnib)	Trials (tipifarnib)	Recent Studies (post-2010) (tipifarnib)	Studies (manumycin)	Trials (manumycin)	Recent Studies (post-2010) (manumycin)
309	92	94	159	0	47

Protein Interaction Comparison

Protein	Taxonomy	tipifarnib (IC50)	manumycin (IC50)
Thioredoxin reductase 1, cytoplasmic	Rattus norvegicus (Norway rat)		0.81
GTPase KRas	Homo sapiens (human)		3.58

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (66.67)	24.3611
2020's	1 (33.33)	2.80

Authors

Authors	Studies
Korzeniecki, C; Priefer, R	1
Crovella, S; De Leo, L; Decorti, G; Marcuzzi, A; Pontillo, A; Tommasini, A	1
Fang, H; Gao, P; Jiang, X; Qiao, J	1

Reviews

1 review(s) available for tipifarnib and manumycin

Article	Year
Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway. European journal of medicinal chemistry, 2021, Feb-05, Volume: 211 Topics: Humans; Models, Molecular; Molecular Structure; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Signal Transduction	2021

Other Studies

2 other study(ies) available for tipifarnib and manumycin

Article	Year
The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency. Pediatric research, 2011, Volume: 70, Issue:1 Topics: Acyclic Monoterpenes; Alendronate; Animals; Anti-Inflammatory Agents; Cell Line; Child; Child, Preschool; Cholesterol; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Inflammation Mediators; Lovastatin; Male; Mevalonate Kinase Deficiency; Mice; Monocytes; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Polyenes; Polyisoprenyl Phosphates; Polyunsaturated Alkamides; Pyridines; Quinolones; Terpenes	2011
In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida. Annals of clinical microbiology and antimicrobials, 2013, Dec-05, Volume: 12 Topics: Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Microbial Sensitivity Tests; Polyenes; Polyunsaturated Alkamides; Quinolones	2013

Article

Year

The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency.

Pediatric research, 2011, Volume: 70, Issue:1

Topics: Acyclic Monoterpenes; Alendronate; Animals; Anti-Inflammatory Agents; Cell Line; Child; Child, Preschool; Cholesterol; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Inflammation Mediators; Lovastatin; Male; Mevalonate Kinase Deficiency; Mice; Monocytes; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Polyenes; Polyisoprenyl Phosphates; Polyunsaturated Alkamides; Pyridines; Quinolones; Terpenes

2011

In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida.

Annals of clinical microbiology and antimicrobials, 2013, Dec-05, Volume: 12

Topics: Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Microbial Sensitivity Tests; Polyenes; Polyunsaturated Alkamides; Quinolones

2013