Page last updated: 2024-09-04

tipifarnib and lonafarnib

tipifarnib has been researched along with lonafarnib in 38 studies

Compound Research Comparison

Studies
(tipifarnib)
Trials
(tipifarnib)
Recent Studies (post-2010)
(tipifarnib)
Studies
(lonafarnib)
Trials
(lonafarnib)
Recent Studies (post-2010) (lonafarnib)
30992942243490
3099294603

Protein Interaction Comparison

ProteinTaxonomytipifarnib (IC50)lonafarnib (IC50)
Chain A, Protein farnesyltransferase alpha subunitRattus norvegicus (Norway rat)0.0019
Chain B, Protein farnesyltransferase beta subunitRattus norvegicus (Norway rat)0.0019
GTPase HRasHomo sapiens (human)0.07
ATP-dependent translocase ABCB1Homo sapiens (human)2.7
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaBos taurus (cattle)0.0083
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaHomo sapiens (human)0.1498
Protein farnesyltransferase subunit betaBos taurus (cattle)0.0083
Protein farnesyltransferase subunit betaHomo sapiens (human)0.1498
Protein farnesyltransferase subunit betaRattus norvegicus (Norway rat)0.0019
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaRattus norvegicus (Norway rat)0.0019
Geranylgeranyl transferase type-1 subunit betaBos taurus (cattle)0.0083

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's30 (78.95)29.6817
2010's6 (15.79)24.3611
2020's2 (5.26)2.80

Authors

AuthorsStudies
Cohen, J; Curtin, ML; Florjancic, AS; Frost, DJ; Gu, WZ; Muchmore, SW; Sham, HL1
Bauch, JL; Cohen, J; Gu, WZ; Hutchins, CW; Jakob, CG; Leonard, NM; Li, Q; Lin, NH; Marsh, K; Park, D; Rosenberg, SH; Sham, HL; Stoll, VS; Sullivan, G; Tong, Y; Wang, GT; Wang, L; Wang, X; Zhang, H1
Bell, IM1
Claiborne, A; Cohen, J; Frost, D; Gu, W; Hasvold, L; Hutchins, C; Jakob, CG; Li, Q; Li, T; Muchmore, S; Rosenberg, SH; Sham, HL; Stoll, VS1
Claiborne, A; Cohen, J; Frost, D; Gu, WZ; Hutchins, C; Li, Q; Lin, NH; Rosenberg, SH; Sham, HL; Stoll, VS; Wang, W; Woods, KW1
Bauer, KD; Bendale, P; Buckner, FS; Chakrabarti, D; Floyd, D; Gelb, MH; Hamilton, A; Hornéy, CP; Lombardo, LJ; Nallan, L; Pendyala, PR; Rivas, K; Sebti, S; Van Voorhis, WC; Weber, PC; Williams, DK; Windsor, WT; Yokoyama, K1
Brunsveld, L; Gelb, MH; Hrycyna, CA; Michaelis, S; Tamanoi, F; Van Voorhis, WC; Waldmann, H1
Bonovolias, ID; Chatzopoulou, M; Demopoulos, VJ; Nicolaou, I; Tsiftsoglou, AS; Vizirianakis, IS1
Distefano, MD; Ochocki, JD1
Buuh, ZY; Lyu, Z; Wang, RE1
Korzeniecki, C; Priefer, R1
Adjei, AA; End, DW; Karp, JE; Kaufmann, SH; Lancet, JE; Wright, JJ1
Bernhard, E; Hahn, SM; McKenna, WG1
Adjei, AA; Dy, GK; Haluska, P1
Dancey, JE1
Caponigro, F1
Adjei, AA; Dy, GK1
Baum, C; Kirschmeier, P1
Kelland, LR1
Cortes, J1
de Bono, JS; Rowinsky, EK; Tolcher, AW1
Tauchi, T1
Cortes, J; Jabbour, E; Kantarjian, H1
Helbig, G; Hołowiecki, J1
Elhamri, M; Thomas, X1
Abbruzzese, A; Budillon, A; Caponigro, F; Caraglia, M; Marra, M; Tagliaferri, P1
Feldman, EJ2
Appels, NM; Beijnen, JH; Schellens, JH1
Jiang, D; Zhang, M1
Harousseau, JL1
Berk, S; Gajewski, TF; Ho, AW; Kuna, T; Marks, RE; Robbel, C1
Le Moulec, S; Loriot, Y; Soria, JC1
Li, M; Liu, A; Liu, B; Luo, X; Yu, H; Zheng, H1
Crovella, S; De Leo, L; Decorti, G; Marcuzzi, A; Pontillo, A; Tommasini, A1
Fernandes, PA; Moorthy, NS; Ramos, MJ; Sousa, SF1
Eşkazan, AE; Özgür Yurttaş, N1
Cohen, J; Frost, D; Galicia, T; Gu, WZ; Hutchins, C; Li, Q; Li, T; Rosenberg, SH; Sham, HL; Stoll, VS; Woods, KW1

Reviews

25 review(s) available for tipifarnib and lonafarnib

ArticleYear
Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy?
    Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Design; Farnesyltranstransferase; Genes, ras; Humans; Neoplasms

2004
Therapeutic intervention based on protein prenylation and associated modifications.
    Nature chemical biology, 2006, Volume: 2, Issue:10

    Topics: Animals; Antineoplastic Agents; Humans; Models, Molecular; Molecular Conformation; Progeria; Protein Prenylation; Proteins

2006
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
    Journal of medicinal chemistry, 2010, Oct-14, Volume: 53, Issue:19

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia; Multipotent Stem Cells; Neoplastic Stem Cells; Pharmacogenetics

2010
Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.
    Journal of medicinal chemistry, 2018, 04-26, Volume: 61, Issue:8

    Topics: Acetylation; Animals; Citrullination; Enzyme Inhibitors; Glycosylation; Humans; Methylation; Phosphorylation; Protein Prenylation; Protein Processing, Post-Translational; Proteins; Ubiquitination

2018
Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway.
    European journal of medicinal chemistry, 2021, Feb-05, Volume: 211

    Topics: Humans; Models, Molecular; Molecular Structure; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Signal Transduction

2021
Current status of clinical trials of farnesyltransferase inhibitors.
    Current opinion in oncology, 2001, Volume: 13, Issue:6

    Topics: Alkyl and Aryl Transferases; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Leukemia; Neoplasms; Piperidines; Pyridines; Quinolones; Signal Transduction

2001
Farnesyltransferase inhibitors.
    Seminars in oncology, 2001, Volume: 28, Issue:5 Suppl 16

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins

2001
Farnesyl transferase inhibitors as anticancer agents.
    European journal of cancer (Oxford, England : 1990), 2002, Volume: 38, Issue:13

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Cell Division; Clinical Trials as Topic; Combined Modality Therapy; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Imidazoles; Neoplasms; Piperidines; Pyridines; Quinolones; Tumor Cells, Cultured

2002
Agents targeting ras signaling pathway.
    Current pharmaceutical design, 2002, Volume: 8, Issue:25

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzamides; Benzodiazepines; Enzyme Inhibitors; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Imidazoles; MAP Kinase Kinase Kinases; Oligonucleotides, Antisense; Phosphorothioate Oligonucleotides; Piperidines; Proto-Oncogene Proteins c-raf; Pyridines; Quinolones; Signal Transduction

2002
Farnesyltransferase inhibitors in breast cancer therapy.
    Cancer investigation, 2002, Volume: 20 Suppl 2

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Female; Fluorouracil; Humans; Mice; Neoplasm Proteins; Paclitaxel; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2002
Preclinical and clinical evaluation of farnesyltransferase inhibitors.
    Current oncology reports, 2003, Volume: 5, Issue:2

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Imidazoles; Piperidines; Pyridines; Quinolones

2003
Farnesyl transferase inhibitors in the treatment of breast cancer.
    Expert opinion on investigational drugs, 2003, Volume: 12, Issue:3

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Female; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins

2003
Farnesyltransferase inhibitors and their potential in the treatment of breast carcinoma.
    Seminars in oncology, 2003, Volume: 30, Issue:5 Suppl 16

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Piperidines; Protein Prenylation; Proto-Oncogene Mas; Pyridines; Quinolones; ras Proteins; Signal Transduction

2003
[Molecular pathogenesis of chronic myeloid leukemia and tyrosine kinase inhibitor].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2004, Volume: 45, Issue:1

    Topics: Animals; Benzamides; Chromosome Aberrations; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Piperidines; Pyridines; Pyrimidines; Quinolones; Randomized Controlled Trials as Topic; Thionucleotides

2004
Clinical activity of farnesyl transferase inhibitors in hematologic malignancies: possible mechanisms of action.
    Leukemia & lymphoma, 2004, Volume: 45, Issue:11

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Cell Line, Tumor; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Hematologic Neoplasms; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins; Signal Transduction

2004
[Ras signaling pathway as a target for farnesyltransferase inhibitors--a new, promising prospects in the treatment for malignant disorders].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2004, Volume: 57, Issue:9-10

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Farnesyltranstransferase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Imidazoles; Neoplasms; Piperidines; Point Mutation; Pyridines; Quinolones; Signal Transduction

2004
[Farnesyltransferase inhibitors: preliminary results in acute myeloid leukemia].
    Bulletin du cancer, 2005, Volume: 92, Issue:3

    Topics: Alkyl and Aryl Transferases; Benzodiazepines; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Leukemia, Myeloid, Acute; Mitogen-Activated Protein Kinase 1; Myeloproliferative Disorders; Piperidines; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Quinolones; ras Proteins; rho GTP-Binding Proteins

2005
Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications.
    Current drug targets, 2005, Volume: 6, Issue:3

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Mevalonic Acid; Neoplasms; Phosphatidylinositol 3-Kinases; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; ras Proteins

2005
Farnesyltransferase inhibitors in myelodysplastic syndrome.
    Current hematology reports, 2005, Volume: 4, Issue:3

    Topics: Acute Disease; Aged; Alkyl and Aryl Transferases; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Progression; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Hematologic Neoplasms; Humans; Leukemia, Myeloid; Middle Aged; Myelodysplastic Syndromes; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Pyridines; Quinolones; Remission Induction; Signal Transduction; Treatment Outcome

2005
Development of farnesyl transferase inhibitors: a review.
    The oncologist, 2005, Volume: 10, Issue:8

    Topics: Animals; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins

2005
[Farnesyl transferase inhibitors--a novel agent for breast cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:4

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Humans; Piperidines; Protein Prenylation; Pyridines; Quinolones; ras Proteins

2006
Farnesyltransferase inihibitors in hematologic malignancies.
    Blood reviews, 2007, Volume: 21, Issue:4

    Topics: Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Hematologic Neoplasms; Humans; Piperidines; Pyridines; Quinolones; Signal Transduction

2007
Farnesyltransferase inhibitors in myelodysplastic syndrome.
    Current hematologic malignancy reports, 2006, Volume: 1, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow Diseases; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Progression; Farnesyltranstransferase; Gastrointestinal Diseases; Genes, ras; Hematologic Neoplasms; Humans; Middle Aged; Myelodysplastic Syndromes; Piperidines; Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; Treatment Outcome

2006
Farnesyltransferase inhibitors: a comprehensive review based on quantitative structural analysis.
    Current medicinal chemistry, 2013, Volume: 20, Issue:38

    Topics: Antineoplastic Agents; Biological Products; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Neoplasms; Piperidines; Pyridines; Quantitative Structure-Activity Relationship; Quinolones

2013
Novel therapeutic approaches in chronic myeloid leukemia.
    Leukemia research, 2020, Volume: 91

    Topics: Antineoplastic Agents; Clinical Trials as Topic; Drug Resistance, Neoplasm; Everolimus; Fusion Proteins, bcr-abl; Gene Expression; Histone Deacetylase Inhibitors; Homoharringtonine; Humans; Immunotherapy; Interferon-alpha; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Targeted Therapy; Niacinamide; Piperidines; Polyethylene Glycols; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Quinolones; Recombinant Proteins

2020

Trials

1 trial(s) available for tipifarnib and lonafarnib

ArticleYear
[Farnesyl transferase inhibitors--a novel agent for breast cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:4

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Humans; Piperidines; Protein Prenylation; Pyridines; Quinolones; ras Proteins

2006

Other Studies

13 other study(ies) available for tipifarnib and lonafarnib

ArticleYear
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.
    Bioorganic & medicinal chemistry letters, 2003, Apr-07, Volume: 13, Issue:7

    Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Biological Availability; Biphenyl Compounds; Crystallography, X-Ray; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Half-Life; Imidazoles; Indicators and Reagents; Mice; Models, Molecular; Rats

2003
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.
    Journal of medicinal chemistry, 2004, Jan-29, Volume: 47, Issue:3

    Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Benzamides; Biological Availability; Cell Membrane Permeability; Crystallography, X-Ray; Dogs; Drug Design; Farnesyltranstransferase; Imidazoles; Models, Molecular; Molecular Structure; Nitriles; Structure-Activity Relationship

2004
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
    Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21

    Topics: 4-Quinolones; Alkyl and Aryl Transferases; Crystallography, X-Ray; Farnesyltranstransferase; Models, Molecular; Pyridones; Quinolones; Structure-Activity Relationship

2004
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Apr-15, Volume: 15, Issue:8

    Topics: Alkyl and Aryl Transferases; Animals; Cattle; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxyquinolines; Indoles; Mice; NIH 3T3 Cells; Quinolones; Stereoisomerism

2005
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
    Journal of medicinal chemistry, 2005, Jun-02, Volume: 48, Issue:11

    Topics: Alkyl and Aryl Transferases; Animals; Antimalarials; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Farnesyltranstransferase; Female; Humans; Malaria; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Plasmodium berghei; Plasmodium falciparum; Protein Prenylation; Quinolones; Rats; Structure-Activity Relationship

2005
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.
    MedChemComm, 2013, Volume: 4, Issue:3

    Topics:

2013
Farnesyl transferase inhibitors: a major breakthrough in anticancer therapy? Naples, 12 April 2002.
    Anti-cancer drugs, 2002, Volume: 13, Issue:8

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Piperidines; Pyridines; Quinolones

2002
Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes.
    Clinical lymphoma, 2003, Volume: 4 Suppl 1

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Farnesyltranstransferase; Humans; Imidazoles; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Piperidines; Pyridines; Quinolones

2003
Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.
    Blood, 2007, Sep-15, Volume: 110, Issue:6

    Topics: Antibodies, Monoclonal; Blotting, Western; CD28 Antigens; CD3 Complex; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; HSP40 Heat-Shock Proteins; Humans; Interferon-gamma; Interleukin-2; Interleukin-4; Lymphocyte Activation; MAP Kinase Kinase 4; Methionine; Phosphorylation; Piperidines; Protein Prenylation; Pyridines; Quinolones; Ribonuclease, Pancreatic; Ribosomal Protein S6 Kinases, 70-kDa; RNA Processing, Post-Transcriptional; T-Lymphocytes; Th1 Cells; Th2 Cells

2007
[Targeting KRAS pathway in NSCLC therapy].
    Bulletin du cancer, 2009, Volume: 96 Suppl

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Non-Small-Cell Lung; Farnesyltranstransferase; Genes, ras; Humans; Lung Neoplasms; Mice; Mitogen-Activated Protein Kinase Kinases; Mutation; Neoplasm Proteins; Niacinamide; Phenylurea Compounds; Piperidines; Pyridines; Quinolones; raf Kinases; ras Proteins; Sorafenib

2009
Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells.
    Cancer letters, 2010, Nov-01, Volume: 297, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Lung Neoplasms; Mechanistic Target of Rapamycin Complex 1; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Mutation; Neuropeptides; Phosphorylation; Piperidines; Prenylation; Proteins; Pyridines; Quinolones; Ras Homolog Enriched in Brain Protein; Ribosomal Protein S6; RNA Interference; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factors; Transfection

2010
The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency.
    Pediatric research, 2011, Volume: 70, Issue:1

    Topics: Acyclic Monoterpenes; Alendronate; Animals; Anti-Inflammatory Agents; Cell Line; Child; Child, Preschool; Cholesterol; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Inflammation Mediators; Lovastatin; Male; Mevalonate Kinase Deficiency; Mice; Monocytes; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Polyenes; Polyisoprenyl Phosphates; Polyunsaturated Alkamides; Pyridines; Quinolones; Terpenes

2011
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Alkyl and Aryl Transferases; Animals; Benzimidazoles; Enzyme Inhibitors; Farnesyltranstransferase; Indoles; Mice; NIH 3T3 Cells; Quinolones

2005