Page last updated: 2024-09-04

tipifarnib and l 778,123

tipifarnib has been researched along with l 778,123 in 12 studies

Compound Research Comparison

Studies (tipifarnib)	Trials (tipifarnib)	Recent Studies (post-2010) (tipifarnib)	Studies (l 778,123)	Trials (l 778,123)	Recent Studies (post-2010) (l 778,123)
309	92	94	23	3	2
309	92	94	15	0	5

Protein Interaction Comparison

Protein	Taxonomy	l 778,123 (IC50)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Bos taurus (cattle)	0.0485
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Homo sapiens (human)	0.3319
Protein farnesyltransferase subunit beta	Bos taurus (cattle)	0.0485
Protein farnesyltransferase subunit beta	Homo sapiens (human)	0.402
Geranylgeranyl transferase type-1 subunit beta	Homo sapiens (human)	0.0983
Protein farnesyltransferase subunit beta	Rattus norvegicus (Norway rat)	0.0036
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Rattus norvegicus (Norway rat)	0.0036

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (83.33)	29.6817
2010's	1 (8.33)	24.3611
2020's	1 (8.33)	2.80

Authors

Authors	Studies
Bernhard, E; Hahn, SM; McKenna, WG	1
Adjei, AA; Dy, GK; Haluska, P	1
Kelland, LR	1
Heymach, JV; Johnson, BE	1
Helbig, G; Hołowiecki, J	1
Elhamri, M; Thomas, X	1
Abbruzzese, A; Budillon, A; Caponigro, F; Caraglia, M; Marra, M; Tagliaferri, P	1
Appels, NM; Beijnen, JH; Schellens, JH	1
Bauch, JL; Cohen, J; Gu, WZ; Hutchins, CW; Jakob, CG; Leonard, NM; Li, Q; Lin, NH; Marsh, K; Park, D; Rosenberg, SH; Sham, HL; Stoll, VS; Sullivan, G; Tong, Y; Wang, GT; Wang, L; Wang, X; Zhang, H	1
Bell, IM	1
Distefano, MD; Ochocki, JD	1
Korzeniecki, C; Priefer, R	1

Reviews

10 review(s) available for tipifarnib and l 778,123

Article	Year
Farnesyltransferase inhibitors. Seminars in oncology, 2001, Volume: 28, Issue:5 Suppl 16 Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins	2001
Farnesyl transferase inhibitors as anticancer agents. European journal of cancer (Oxford, England : 1990), 2002, Volume: 38, Issue:13 Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzodiazepines; Cell Division; Clinical Trials as Topic; Combined Modality Therapy; Enzyme Inhibitors; Farnesyltranstransferase; Genes, ras; Humans; Imidazoles; Neoplasms; Piperidines; Pyridines; Quinolones; Tumor Cells, Cultured	2002
Farnesyl transferase inhibitors in the treatment of breast cancer. Expert opinion on investigational drugs, 2003, Volume: 12, Issue:3 Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Farnesyltranstransferase; Female; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins	2003
Farnesyl transferase inhibitors for patients with lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-15, Volume: 10, Issue:12 Pt 2 Topics: Alkyl and Aryl Transferases; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Farnesyltranstransferase; Humans; Imidazoles; Lung Neoplasms; Quinolones; Signal Transduction; Treatment Outcome	2004
[Ras signaling pathway as a target for farnesyltransferase inhibitors--a new, promising prospects in the treatment for malignant disorders]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2004, Volume: 57, Issue:9-10 Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Farnesyltranstransferase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Imidazoles; Neoplasms; Piperidines; Point Mutation; Pyridines; Quinolones; Signal Transduction	2004
[Farnesyltransferase inhibitors: preliminary results in acute myeloid leukemia]. Bulletin du cancer, 2005, Volume: 92, Issue:3 Topics: Alkyl and Aryl Transferases; Benzodiazepines; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Leukemia, Myeloid, Acute; Mitogen-Activated Protein Kinase 1; Myeloproliferative Disorders; Piperidines; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Quinolones; ras Proteins; rho GTP-Binding Proteins	2005
Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications. Current drug targets, 2005, Volume: 6, Issue:3 Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Benzodiazepines; Farnesyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Mevalonic Acid; Neoplasms; Phosphatidylinositol 3-Kinases; Piperidines; Protein Prenylation; Protein Processing, Post-Translational; Pyridines; Quinolones; ras Proteins	2005
Development of farnesyl transferase inhibitors: a review. The oncologist, 2005, Volume: 10, Issue:8 Topics: Animals; Antineoplastic Agents; Benzodiazepines; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Imidazoles; Piperidines; Pyridines; Quinolones; ras Proteins	2005
Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy? Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8 Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Design; Farnesyltranstransferase; Genes, ras; Humans; Neoplasms	2004
Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway. European journal of medicinal chemistry, 2021, Feb-05, Volume: 211 Topics: Humans; Models, Molecular; Molecular Structure; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Signal Transduction	2021

Other Studies

2 other study(ies) available for tipifarnib and l 778,123

Article	Year
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors. Journal of medicinal chemistry, 2004, Jan-29, Volume: 47, Issue:3 Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Benzamides; Biological Availability; Cell Membrane Permeability; Crystallography, X-Ray; Dogs; Drug Design; Farnesyltranstransferase; Imidazoles; Models, Molecular; Molecular Structure; Nitriles; Structure-Activity Relationship	2004
Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections. MedChemComm, 2013, Volume: 4, Issue:3 Topics:	2013

Article

Year

Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.

Journal of medicinal chemistry, 2004, Jan-29, Volume: 47, Issue:3

Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Benzamides; Biological Availability; Cell Membrane Permeability; Crystallography, X-Ray; Dogs; Drug Design; Farnesyltranstransferase; Imidazoles; Models, Molecular; Molecular Structure; Nitriles; Structure-Activity Relationship

2004

Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.

MedChemComm, 2013, Volume: 4, Issue:3

Topics:

2013