Page last updated: 2024-08-23

tiotidine and cimetidine

tiotidine has been researched along with cimetidine in 119 studies

Research

Studies (119)

Timeframe	Studies, this research(%)	All Research%
pre-1990	55 (46.22)	18.7374
1990's	39 (32.77)	18.2507
2000's	22 (18.49)	29.6817
2010's	3 (2.52)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Buschauer, A; Elz, S; Hirschfeld, J; Ruat, M; Schunack, W; Schwartz, JC; Traiffort, E	1
Timmerman, H	1
Brown, TH; Ganellin, CR; Griffiths, R; Jones, M; Mitchell, RC; Rana, KK; Saunders, D; Smith, IR; Sore, NE; Young, RC	1
Baldwin, JJ; Bolhofer, WA; Cragoe, EJ; Habecker, CN; Hoffman, JM; Lumma, WC; Phillips, BT; Pietruszkiewicz, AM; Torchiana, ML	1
Blake, JF; Curatolo, WJ; Lombardo, F	1
Beukers, MW; De Grip, WJ; Klaassen, CH; Leurs, R; Timmerman, H; Verzijl, D	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Bakker, RA; Leurs, R; Lim, HD; Ling, P; Thurmond, RL; van Rijn, RM	1
Biagini, GA; Chandramohanadas, R; Darling, C; DeGrado, WF; Diamond, SL; Fisher, N; Greenbaum, DC; Jing, H; Jo, H; Lucumi, E; Napper, AD; Shone, AE; Ward, SA	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Buck, SH; Gilman, DJ; Jones, DF; Wardleworth, JM; Yellin, TO	1
Flezar, M; Florio, C; Heisler, S; Martin, JG	1
Campillo, M; Giraldo, J; Martín, M; Pardo, L	1
Hough, LB; Nalwalk, JW	2
DelValle, J; Gantz, I; Guo, YJ; Konda, Y; Munzert, G; Tashiro, T; Wang, LD; Yamada, T	1
Barker, LA; Petropoulos, AC; Winbery, SL	1
Endou, M; Gando, S; Hattori, Y; Kanno, M	2
Arima, N; Chiba, T; Kinoshita, Y; Nakamura, A; Nakata, H; Yamashita, Y	1
Orsetti, M; Sorba, G	1
Nowak, JZ; Sek, B	1
Gabel, RA; Macia, RA; Matthews, WD; Reginato, MJ	1
Krielaart, MJ; van Buuren, KJ; Veenstra, DM	1
Black, JW; Shankley, NP	3
Hellstrand, K; Hermodsson, S	1
Arrang, JM; Garbarg, M; Schwartz, JC	1
Jais, AM; Ridzwan, BH; Waton, NG	1
Gajtkowski, GA; Norris, DB; Rising, TJ; Wood, TP	1
Belfiore, P; Giachetti, A; Micheletti, R; Nicosia, S; Oliva, D	1
Foreman, JC; Norris, DB; Rising, TJ; Webber, SE	2
Black, JW; Leff, P; Shankley, NP	1
Batzri, S; Harmon, JW	1
Nielsen, ST	1
Bast, A; Kramer, K; Timmerman, H	1
Calcutt, CR; Ganellin, CR; Griffiths, R; Leigh, BK; Maguire, JP; Mitchell, RC; Mylek, ME; Parsons, ME; Smith, IR; Young, RC	1
Bast, A; Rekka, E; Sterk, GJ; Timmerman, H	1
Crissman, JW; Robertson, JL; Streett, CS	1
Barker, LA; Winbery, SL	1
Al-Gadi, M; Hill, SJ	1
Leff, P; Trist, DG	1
Black, J; Gerskowitch, VP; Leff, P; Shankley, NP; Trist, DG	1
Rademaker, B; Sterk, GJ; Timmerman, H; van der Goot, H; van der Schaar, MW	1
Hughes, MJ; Kilpatrick, C; Light, KE; Serbus, DC	1
Leigh, BK; Mylek, ME; Smith, IR	1
Coombes, JD; Norris, DB; Rising, TJ; Ross, BC; Steward, A	1
Fedan, JS; Hogaboom, GK; Horstemeyer, DL; Ice, KS; O'donnell, JP; Smith, DJ	1
Bast, A; Kroes, BH; Savenije-Chapel, EM	1
Levi, R; Trzeciakowski, JP	1
Brater, C; Feldman, M; Richardson, CT; Welborn, J	1
Brater, DC; Feldman, M; Kaojarern, S; Richardson, CT	1
Domschke, S; Domschke, W	1
Douglas, AP; Strecker, RB; Valenzuela, JE	1
Cheret, AM; Lewin, MJ; Pignal, F	1
Avant, GR; Mitchell, MC; Patwardhan, RV; Schenker, S; Speeg, KV	1
Bertaccini, G; Coruzzi, G	1
Barker, LA	1
Batzri, S; Dyer, J; Harmon, JW; Thompson, WF	1
Buyniski, JP; Cavanagh, RL; Usakewicz, JJ	1
Dinoso, VP	1
Radbil', OS; Sukherova, MI	1
Flannery, MC; Johnston, BJ; McIsaac, RL	1
Bertaccini, G; Coruzzi, G; Fesani, F; Medici, D; Poli, E	1
Hirata, Y; Ishii, Y; Yanagisawa, I	1
Calvete, JA; Donegan, JL; Hayes, RJ; Oates, NS; Sloan, TP	1
Dobson, P; Yellin, TO	1
Cimprich, RE; Robertson, JL; Streett, CS	1
Yellin, TO; Zavecz, JH	1
Lewis, S; Rising, TJ	1
Johnson, CL; Kalinyak, K; Sawutz, DG; Whitsett, JA	1
Daly, MJ; Humphray, JM; Stables, R	1
Gajtkowski, GA; Norris, DB; Rising, TJ	1
Asano, T; Fukushima, Y; Katagiri, H; Matsuhashi, N; Oka, Y; Saitoh, T; Sugano, K; Takata, K; van Breda, E; Yazaki, Y	1
Ballabeni, V; Barocelli, E; Chiavarini, M; Impicciatore, M	1
Arima, N; Chiba, T; Kinoshita, Y; Nakamura, A; Yamashita, Y	1
Inaba, N; Ohnishi, H; Onodera, S; Shibata, M; Suzuki, T; Tanaka, M; Yamaura, T	1
Abita, JP; Callebert, J; Chastre, E; Gespach, C; Housset, B; Launay, JM; Mirossay, L; Zimber, A	1
Fukushima, Y; Kodama, T; Matsuhashi, N; Mori, H; Saitoh, T; Sugano, K; Yazaki, Y	1
Hough, LB; Mischler, SA; Nalwalk, JW; Thoburn, KK	1
Hamada, K; Kobayashi, F; Sekiguchi, H; Taga, F; Uchida, H	1
Bondoux, D; Emami, S; Gespach, C; Haimart, M; Launay, JM; Mutel, V; Oset-Gasque, MJ	1
Fukuda, K; Matsumura, F; Tanaka, S	1
Asano, T; Fukushima, Y; Ishihara, H; Katagiri, H; Kodama, T; Matsuhashi, N; Oka, Y; Saitoh, T; Sugano, K; Yazaki, Y	1
Clark, EA; Hill, SJ	1
Agut, J; Ortiz, JA; Sacristán, A; Sánchez, JC	1
Aihara, M; Anai, M; Asano, T; Fukushima, Y; Funaki, M; Katagiri, H; Matsuhashi, N; Ogihara, T; Oka, Y; Saitoh, T; Sugano, K; Takata, K; Tsukuda, K; Yazaki, Y	1
Bergoc, R; Cricco, G; Davio, C; Duran, H; Fitzsimons, C; Molinari, B; Palmieri, M; Rivera, E	1
Bizot-Espiard, JG; Caignard, DH; Guillaumet, G; Pfeiffer, B; Renard, P; Savelon, L; Viaud, MC	1
Bergoc, R; Davio, C; Legnazzi, BL; Monczor, F; Rivera, E	1
Davio, C; Legnazzi, BL; Monczor, F; Rivera, E	1
Durán, H; Fitzsimons, C; Labombarda, F; Molinari, B; Rivera, E	1
Del Valle, J; Gantz, I; Hoeltzel, M; Hunter, R; Wang, LD	1
Buschauer, A; Schulze, FR; Schunack, W; Wolf, C	1
Fukuoka, M; Haraguchi, R; Iwanaga, T; Kubo, H; Nakajima, S; Tohda, Y	1
Carman-Krzan, M; Lipnik-Stangelj, M	1
Asano, T; Fukushima, Y; Kajiwara, T; Katsube, T; Mori, H; Ogawa, K; Ohkawa, SI; Otsuka, H; Saitoh, T; Takahashi, H; Tamai, M	1
Baldi, A; Brodsky, A; Davio, C; Fernandez, N; Lemos Legnazzi, B; Martin, ME; Monczor, F; Shayo, C	1
Falus, A; László, V; Orsó, E; Pállinger, E; Pós, Z; Rothe, G; Schmitz, G; Szeberényi, JB; Szeberényi, S; Zsinkó, M	1
Buschauer, A; Kelley, MT; Seifert, R; Wenzel-Seifert, K	1
Buzás, E; Falus, A; Fitzsimons, CP; Lazar-Molnar, E; Rivera, ES; Tomoskozi, Z	1
Bürckstümmer, T; Buschauer, A; Dove, S; Kelley, MT; Seifert, R; Wenzel-Seifert, K	1
Anai, M; Asano, T; Fukushima, Y; Ishikawa, M; Ishikawa, T; Kajiwara, T; Katsube, T; Ogawa, K; Ohkawa, S; Omata, M; Otsuka, H; Saitoh, T	1
Nowak, JZ; Przybysz, M; Zalewska-Kaszubska, J; Zawilska, JB	1
Anai, M; Asano, T; Fujishiro, M; Fukushima, Y; Funaki, M; Inukai, K; Ishikawa, T; Nagai, R; Ogihara, T; Omata, M; Onishi, Y; Ono, H; Saitoh, T; Sakoda, H; Tsukuda, K	1
Anai, M; Asano, T; Fukushima, Y; Ishikawa, M; Ishikawa, T; Kajiwara, T; Katsube, T; Mori, H; Ogawa, K; Ohkawa, S; Omata, M; Otsuka, H; Saitoh, T; Takahashi, H; Tamai, M	1
Fogel, WA; Stasiak, A; Wagner, W	1
Arias-Montaño, JA; García, L; Guerrero-Hernández, A; Rueda, A; Soria-Jasso, LE	1
Durán, H; Engel, N; Fitzsimons, C; Molinari, B; Policastro, L; Rivera, E	1
Nowak, JZ; Woldan-Tambor, A; Zawilska, JB	1
Aceves, J; Arias-Montaño, JA; Bárbara, A	1
Baldi, A; Davio, C; Fernandez, N; Legnazzi, BL; Monczor, F; Riveiro, ME; Shayo, C	1
Cannon, KE; Fleck, MW; Hough, LB	1
Monczor, F	1
Alisch, R; Buschauer, A; Elz, S; Sadek, B	1

Reviews

3 review(s) available for tiotidine and cimetidine

Article	Year
Histamine H3 ligands: just pharmacological tools or potential therapeutic agents? Journal of medicinal chemistry, 1990, Volume: 33, Issue:1 Topics: Animals; Histamine; Histamine Antagonists; Molecular Structure; Neurotransmitter Agents; Receptors, Histamine; Receptors, Histamine H3; Structure-Activity Relationship	1990
New histamine H2-receptor antagonists. Hepato-gastroenterology, 1980, Volume: 27, Issue:3 Topics: Animals; Anticoagulants; Chemical Phenomena; Chemistry; Cimetidine; Confusion; Dogs; Drug Interactions; Duodenal Ulcer; Furans; Gastric Juice; Gastric Mucosa; Guanidines; Gynecomastia; Histamine H2 Antagonists; Humans; Imidazoles; Male; Molecular Conformation; Ranitidine; Spermatozoa; Thiazoles	1980
[New generation of histamine H2 receptor blockaders]. Sovetskaia meditsina, 1982, Issue:12 Topics: Animals; Anti-Ulcer Agents; Cimetidine; Furans; Guanidines; Histamine H2 Antagonists; Humans; Imidazoles; Ranitidine; Thiazoles	1982

Trials

2 trial(s) available for tiotidine and cimetidine

Article	Year
Tiotidine, a new long-acting histamine H2-receptor antagonist: comparison with cimetidine. Gastroenterology, 1981, Volume: 80, Issue:2 Topics: Adult; Cimetidine; Duodenal Ulcer; Gastric Acid; Gastric Emptying; Gastrins; Guanidines; Histamine H2 Antagonists; Humans; Middle Aged; Polyethylene Glycols; Thiazoles	1981
Tiotidine, a new H2-receptor antagonist, is a potent inhibitor of nocturnal acid secretion in duodenal ulcer patients. Digestive diseases and sciences, 1981, Volume: 26, Issue:5 Topics: Adult; Cimetidine; Drug Evaluation; Duodenal Ulcer; Gastric Acid; Guanidines; Histamine H2 Antagonists; Humans; Middle Aged; Thiazoles	1981

Other Studies

114 other study(ies) available for tiotidine and cimetidine

Article	Year
Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor. Journal of medicinal chemistry, 1992, Jun-12, Volume: 35, Issue:12 Topics: Aniline Compounds; Animals; Atrial Function; Azides; Guanidines; Guinea Pigs; Heart Atria; Heart Rate; Iodine Radioisotopes; Male; Muscle Contraction; Receptors, Histamine H2; Structure-Activity Relationship; Sulfonamides; Vasoconstriction	1992
Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists. Journal of medicinal chemistry, 1988, Volume: 31, Issue:3 Topics: Algorithms; Animals; Blood-Brain Barrier; Brain; Chemical Phenomena; Chemistry, Physical; Clonidine; Guinea Pigs; Histamine H2 Antagonists; Imipramine; Pyrilamine; Structure-Activity Relationship	1988
Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine. Journal of medicinal chemistry, 1983, Volume: 26, Issue:2 Topics: Animals; Benzene Derivatives; Biological Assay; Cimetidine; Dogs; Folic Acid; Gastric Juice; Guanidines; Guinea Pigs; Heart Atria; Histamine H2 Antagonists; Indicators and Reagents; Myocardial Contraction; Receptors, Histamine; Receptors, Histamine H2; Structure-Activity Relationship; Thiazoles	1983
Computation of brain-blood partitioning of organic solutes via free energy calculations. Journal of medicinal chemistry, 1996, Nov-22, Volume: 39, Issue:24 Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics	1996
Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells. British journal of pharmacology, 1997, Volume: 122, Issue:5 Topics: Adenylyl Cyclases; Animals; Baculoviridae; beta-Cyclodextrins; Blotting, Western; Cell Line, Transformed; Cholesterol; Cimetidine; Cyclic AMP; Cyclodextrins; Epitopes; Fluorescent Antibody Technique; Guanidines; Histamine H2 Antagonists; Histidine; Insecta; Microscopy, Confocal; Oligonucleotides; Piperidines; Ranitidine; Rats; Receptors, Histamine H2; Transfection	1997
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:3 Topics: Cell Line; Histamine Agonists; Humans; Imidazoles; Indoles; Isothiuronium; Ligands; Methylhistamines; Piperazines; Radioligand Assay; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Receptors, Histamine H4	2005
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9 Topics: Animals; Antimalarials; Drug Resistance, Multiple; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
ICI 125,211: a new gastric antisecretory agent acting on histamine H2-receptors. Life sciences, 1979, Dec-03, Volume: 25, Issue:23 Topics: Animals; Cimetidine; Dogs; Female; Gastric Mucosa; Guanidines; Guinea Pigs; Heart; Heart Rate; Histamine; Histamine H2 Antagonists; Myocardial Contraction; Thiazoles; Thiourea; Time Factors	1979
Identification of adenylate cyclase-coupled histamine H2 receptors in guinea pig tracheal smooth muscle cells in culture and the effect of dexamethasone. American journal of respiratory cell and molecular biology, 1992, Volume: 7, Issue:6 Topics: Adenylyl Cyclases; Animals; Calcium; Cations, Divalent; Cells, Cultured; Cimetidine; Cyclic AMP; Cyclic GMP; Dexamethasone; Guinea Pigs; Histamine; Male; Muscle, Smooth; Receptors, Histamine H2; Trachea	1992
Theoretical studies on the histamine H2 receptor: molecular mechanism of action of antagonists. Molecular pharmacology, 1992, Volume: 42, Issue:2 Topics: Cimetidine; Computer Simulation; Guanidines; Histamine H1 Antagonists; Histamine H2 Antagonists; Kinetics; Models, Chemical; Molecular Conformation; Ranitidine; Receptors, Histamine H1; Structure-Activity Relationship	1992
Inhibition of morphine antinociception by centrally administered histamine H2 receptor antagonists. European journal of pharmacology, 1992, Apr-29, Volume: 215, Issue:1 Topics: Animals; Benzothiazoles; Brain; Cimetidine; Histamine H2 Antagonists; Injections, Intraventricular; Male; Morphine; Nociceptors; Phenoxypropanolamines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Thiazoles	1992
Modulation of morphine antinociception by antagonism of H2 receptors in the periaqueductal gray. Brain research, 1992, Aug-14, Volume: 588, Issue:1 Topics: Analgesics; Animals; Cimetidine; Dose-Response Relationship, Drug; Histamine H2 Antagonists; Injections; Male; Morphine; Pain Measurement; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Histamine H2	1992
Molecular basis for the interaction of histamine with the histamine H2 receptor. The Journal of biological chemistry, 1992, Oct-15, Volume: 267, Issue:29 Topics: Amino Acid Sequence; Animals; Cell Membrane; Cimetidine; Cloning, Molecular; Cyclic AMP; Dogs; Histamine; Histamine H2 Antagonists; Kinetics; Liver Neoplasms, Experimental; Mutagenesis, Site-Directed; Rats; Receptors, Histamine H2; Transfection; Tumor Cells, Cultured	1992
Effect of short-term treatment with gastrin and related peptides on gastrointestinal histamine H2-receptors. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:2 Topics: Adenylyl Cyclases; Animals; Cimetidine; Digestive System; Dimaprit; Gastrins; Guinea Pigs; Histamine; In Vitro Techniques; Male; Pentagastrin; Receptors, Histamine H2; Sincalide; Thiourea	1992
Characterization of histamine receptors modulating inotropic and biochemical activities in rabbit left atria. European journal of pharmacology, 1991, Apr-10, Volume: 196, Issue:1 Topics: Animals; Atrial Function; Cardiotonic Agents; Cimetidine; Female; Heart; Heart Atria; Histamine; Hydrolysis; Inositol Phosphates; Male; Myocardial Contraction; Phosphatidylinositols; Pyrilamine; Rabbits; Receptors, Histamine H1; Receptors, Histamine H2; Stimulation, Chemical; Tritium	1991
Presence of histamine H2-receptors on human gastric carcinoma cell line MKN-45 and their increase by retinoic acid treatment. Biochemical and biophysical research communications, 1991, May-15, Volume: 176, Issue:3 Topics: Binding, Competitive; Cell Line; Cimetidine; Cyclic AMP; Histamine; Histamine H2 Antagonists; Humans; Kinetics; Receptors, Histamine H2; Stomach Neoplasms; Tretinoin	1991
Characterization of an accessory binding area in the histamine H2 receptor. European journal of pharmacology, 1991, Jul-12, Volume: 207, Issue:3 Topics: Animals; Binding Sites; Cerebral Cortex; Cimetidine; Guinea Pigs; Heart Atria; Histamine H2 Antagonists; Ileum; Male; Piperidines; Ranitidine; Receptors, Histamine H2; Structure-Activity Relationship; Triazoles	1991
Cyclic AMP generating systems in vertebrate retina: effects of histamine and an established retinal modulator, dopamine. Agents and actions, 1991, Volume: 33, Issue:1-2 Topics: Adenylyl Cyclases; Animals; Cerebral Cortex; Chickens; Cimetidine; Colforsin; Cyclic AMP; Dimaprit; Dopamine; Female; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Methylhistamines; Pyrilamine; Receptors, Histamine H1; Receptors, Histamine H2; Retina; Thiazoles; Thiourea	1991
Hypotension induced by growth-hormone-releasing peptide is mediated by mast cell serotonin release in the rat. Toxicology and applied pharmacology, 1990, Volume: 104, Issue:3 Topics: Analysis of Variance; Animals; Cimetidine; Cyproheptadine; Dose-Response Relationship, Drug; Drug Synergism; Growth Hormone-Releasing Hormone; Histamine H2 Antagonists; Histamine Release; Hormones; Hypotension; Injections, Intravenous; Ketanserin; Male; Mast Cells; Naloxone; Oligopeptides; Pyrilamine; Rats; Rats, Inbred Strains; Serotonin	1990
Mechanism of action of H2-antagonists on histamine- or dimaprit-stimulated H2-receptors of spontaneously beating guinea-pig atrium. Agents and actions, 1990, Volume: 31, Issue:1-2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cimetidine; Dimaprit; Famotidine; Female; Guinea Pigs; Heart; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Radioligand Assay; Ranitidine; Receptors, Histamine H2; Thiourea	1990
Identification and characterization of histamine H1- and H2-receptors in guinea-pig left atrial membranes by [3H]-mepyramine and [3H]-tiotidine binding. British journal of pharmacology, 1991, Volume: 103, Issue:2 Topics: Animals; Cimetidine; Female; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Guinea Pigs; Heart Atria; In Vitro Techniques; Kinetics; Male; Membranes; Myocardial Contraction; Pyrilamine; Receptors, Histamine H1; Receptors, Histamine H2	1991
The isolated stomach preparation of the mouse: a physiological unit for pharmacological analysis. British journal of pharmacology, 1985, Volume: 86, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Atropine Derivatives; Benzimidazoles; Cimetidine; Fasting; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mice; Muscarine; Omeprazole; Pentagastrin; Pressure; Tetrodotoxin; Thiocyanates	1985
Pharmacological analysis of the muscarinic receptors involved when McN-A 343 stimulates acid secretion in the mouse isolated stomach. British journal of pharmacology, 1985, Volume: 86, Issue:3 Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Atropine; Benzodiazepinones; Cimetidine; Drug Interactions; Gastric Acid; Histamine H2 Antagonists; In Vitro Techniques; Mice; Muscarine; Parietal Cells, Gastric; Pirenzepine; Quaternary Ammonium Compounds; Receptors, Muscarinic; Tetrodotoxin	1985
Differential effects of histamine receptor antagonists on human natural killer cell activity. International archives of allergy and applied immunology, 1987, Volume: 84, Issue:3 Topics: Cell Survival; Cimetidine; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Histamine H2 Antagonists; Interferons; Killer Cells, Natural; Leukocytes, Mononuclear; Ranitidine	1987
Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors. Neuroscience, 1987, Volume: 23, Issue:1 Topics: Animals; Burimamide; Cerebral Cortex; Cimetidine; Histamine; Histamine Release; Hypothalamus; Hypothalamus, Posterior; Imidazoles; Impromidine; Male; Potassium; Pyrilamine; Rats; Rats, Inbred Strains; Receptors, Histamine; Receptors, Histamine H3; Synaptosomes; Thiazoles	1987
Anti-acid secretion activity of drugs cimetidine, ranitidine, tiotidine D 15,144 in dogs fixed with gastric fistulae. General pharmacology, 1989, Volume: 20, Issue:2 Topics: Animals; Cimetidine; Dogs; Female; Gastric Acid; Gastric Fistula; Histamine H2 Antagonists; Ranitidine; Time Factors	1989
The use of an in vitro binding assay to predict histamine H2-antagonist activity. Agents and actions, 1985, Volume: 16, Issue:3-4 Topics: Adenylyl Cyclase Inhibitors; Animals; Cimetidine; Female; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Male; Receptors, Histamine H2; Tritium	1985
Evaluation of novel compounds interacting with H2-histamine receptors: effect on histamine-sensitive adenylate cyclase activity in guinea-pig gastric mucosa. Agents and actions, 1985, Volume: 16, Issue:5 Topics: Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; Cimetidine; Gastric Mucosa; Guinea Pigs; Histamine; Histamine H2 Antagonists; Imidazoles; Male	1985
The binding of [3H]-tiotidine to homogenates of guinea-pig lung parenchyma. British journal of pharmacology, 1985, Volume: 86, Issue:2 Topics: Animals; Binding, Competitive; Cimetidine; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Kinetics; Lung	1985
Pharmacological analysis of the pentagastrin-tiotidine interaction in the mouse isolated stomach. British journal of pharmacology, 1985, Volume: 86, Issue:3 Topics: Animals; Binding, Competitive; Cimetidine; Gastric Acid; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Mathematics; Mice; Models, Biological; Parietal Cells, Gastric; Pentagastrin	1985
Pharmacological analysis of muscarinic receptors coupled to oxyntic cell secretion in the mouse stomach. British journal of pharmacology, 1985, Volume: 86, Issue:3 Topics: Animals; Atropine; Atropine Derivatives; Benzodiazepinones; Binding, Competitive; Cimetidine; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Mice; Muscarine; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Parietal Cells, Gastric; Pirenzepine; Receptors, Muscarinic; Trachea	1985
A study of the H2-receptor for histamine stimulating adenylate cyclase in homogenates of guinea-pig lung parenchyma. British journal of pharmacology, 1986, Volume: 87, Issue:1 Topics: Adenylyl Cyclases; Animals; Cimetidine; Colforsin; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Lung; Male; Propranolol; Pyrilamine; Receptors, Histamine; Receptors, Histamine H2	1986
Is [3H]-tiotidine a specific ligand for the H2-receptor? Pharmacology, 1986, Volume: 32, Issue:5 Topics: Animals; Binding, Competitive; Cimetidine; Cyclic AMP; Gastric Mucosa; Guinea Pigs; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Radioligand Assay; Receptors, Histamine; Receptors, Histamine H2	1986
Tiotidine and ICIA 5165 inhibit central and peripheral H2 receptors with equal potency. Pharmacology, 1987, Volume: 34, Issue:1 Topics: Adenylyl Cyclase Inhibitors; Animals; Cimetidine; Guanidines; Guinea Pigs; Heart Rate; Hippocampus; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Thiazoles	1987
Relation between pharmacological response and receptor binding with histamine blocking drugs. Irreversible antagonism of three analogues of mifentidine on right atrium and cerebral cortex of the guinea-pig. Agents and actions, 1987, Volume: 21, Issue:1-2 Topics: Animals; Cell Membrane; Cerebral Cortex; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Heart; Heart Atria; Histamine H2 Antagonists; Imidazoles; Male; Receptors, Histamine H2	1987
Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. British journal of pharmacology, 1988, Volume: 93, Issue:1 Topics: Animals; Benzothiazoles; Binding, Competitive; Brain Chemistry; Cimetidine; Cyclic AMP; Female; Guinea Pigs; Hippocampus; Histamine H2 Antagonists; In Vitro Techniques; Male; Phenoxypropanolamines; Piperidines; Rats; Thiazoles; Uterus	1988
Identification of structural characteristics of some potential H2-receptor antagonists that determine the interaction with rat hepatic P-450. Chemico-biological interactions, 1988, Volume: 67, Issue:1-2 Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Histamine H2 Antagonists; Male; Microsomes, Liver; Molecular Structure; NADP; Ranitidine; Rats; Rats, Inbred Strains; Structure-Activity Relationship	1988
Morphologic stomach findings in rats and mice treated with the H2 receptor antagonists, ICI 125,211 and ICI 162,846. Toxicologic pathology, 1988, Volume: 16, Issue:2 Topics: Animals; Carcinogens; Cimetidine; Female; Histamine H2 Antagonists; Male; Mice; Mice, Inbred Strains; Pyrazoles; Rats; Rats, Inbred Strains; Stomach; Stomach Diseases; Stomach Neoplasms	1988
Metronidazole and 5-aminosalicylic acid enhance the contractile activity of histaminergic agonists on the guinea-pig isolated ileum. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3 Topics: Aminosalicylic Acids; Animals; Cimetidine; Computers; Dimaprit; Dose-Response Relationship, Drug; Drug Synergism; Duodenum; Female; Guinea Pigs; Heart; Histamine; Ileum; In Vitro Techniques; Jejunum; Male; Mesalamine; Metronidazole; Muscle Contraction; Myenteric Plexus; Pyrilamine; Receptors, Histamine; Scopolamine; Tetrodotoxin; Thiourea	1986
Characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in rabbit cerebral cortical slices. British journal of pharmacology, 1985, Volume: 85, Issue:4 Topics: Adenosine; Animals; Cerebral Cortex; Chlorpheniramine; Cimetidine; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Imidazoles; Impromidine; Kinetics; Mathematics; Metiamide; Rabbits; Ranitidine; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Thiazoles	1985
Quantification of H2-agonism by clonidine and dimaprit in an adenylate cyclase assay. Agents and actions, 1985, Volume: 16, Issue:3-4 Topics: Adenylyl Cyclases; Animals; Cimetidine; Clonidine; Dimaprit; Guinea Pigs; Histamine; In Vitro Techniques; Myocardium; Receptors, Histamine; Receptors, Histamine H2; Thiourea	1985
Resultant action of cimetidine in a cardiac adenylate cyclase assay: its elucidation by concentration-ratios analysis. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3 Topics: Adenylyl Cyclases; Animals; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Heart Rate; Histamine; Male; Myocardium; Receptors, Histamine H2	1987
Histamine H2-binding on guinea pig cerebral cortex. Agents and actions, 1986, Volume: 18, Issue:1-2 Topics: Animals; Cerebral Cortex; Cimetidine; Gastric Acid; Guinea Pigs; Histamine; In Vitro Techniques; Myocardium; Receptors, Histamine; Receptors, Histamine H2; Tritium	1986
Antagonistic activity of tiotidine and ranitidine on guinea-pig and rabbit atria. European journal of pharmacology, 1986, Nov-12, Volume: 131, Issue:1 Topics: Animals; Cimetidine; Female; Guinea Pigs; Heart Rate; Histamine Antagonists; In Vitro Techniques; Kinetics; Male; Myocardial Contraction; Rabbits; Ranitidine	1986
3H-tiotidine binding to guinea-pig cortical and striatal membranes. Agents and actions, 1986, Volume: 19, Issue:3-4 Topics: Animals; Cerebral Cortex; Cimetidine; Corpus Striatum; Guinea Pigs; In Vitro Techniques; Kinetics; Membranes	1986
In vitro histamine H2-antagonist activity of the novel compound HUK 978. Life sciences, 1985, Nov-04, Volume: 37, Issue:18 Topics: Adenylyl Cyclases; Animals; Cerebral Cortex; Cimetidine; Dose-Response Relationship, Drug; Gastric Mucosa; Guanidines; Guinea Pigs; Histamine; Ileum; Receptors, Histamine; Receptors, Histamine H2; Thiazoles	1985
Binding of 4(5)-[2-(4-azido-2-nitroanilino)ethyl]imidazole to histamine receptors in guinea pig cerebral cortical membranes. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1986, Volume: 181, Issue:4 Topics: Animals; Binding, Competitive; Cerebral Cortex; Cimetidine; Guinea Pigs; Histamine; Kinetics; Male; Membranes; Pyrilamine; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H2; Substrate Specificity; Vas Deferens	1986
Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers. Xenobiotica; the fate of foreign compounds in biological systems, 1984, Volume: 14, Issue:5 Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Ranitidine; Rats; Rats, Inbred Strains; Safrole	1984
The cardiac pharmacology of tiotidine (LCL 125, 211): a new histamine H2-receptor antagonist. The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Node; Cimetidine; Guanidines; Guinea Pigs; Heart; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Myocardial Contraction; Thiazoles	1980
New drugs for peptic ulcer. British medical journal, 1980, Jul-12, Volume: 281, Issue:6233 Topics: Benzamides; Benzodiazepinones; Cimetidine; Furans; Guanidines; Histamine H2 Antagonists; Humans; Morpholines; Parasympatholytics; Pepsin A; Peptic Ulcer; Piperazines; Pirenzepine; Prostaglandins E, Synthetic; Ranitidine; Thiazoles; Trimipramine	1980
Tiotidine and cimetidine--kinetics and dynamics. Clinical pharmacology and therapeutics, 1981, Volume: 29, Issue:2 Topics: Adult; Cimetidine; Dose-Response Relationship, Drug; Female; Guanidines; Histamine H2 Antagonists; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Middle Aged; Thiazoles; Time Factors	1981
Effects of H2-receptor antagonists cimetidine, ranitidine, and ICI 125,211 on histamine-stimulated adenylate cyclase activity in guinea pig gastric mucosa. Molecular pharmacology, 1981, Volume: 20, Issue:2 Topics: Adenylyl Cyclases; Animals; Cimetidine; Furans; Gastric Mucosa; Guanidines; Guinea Pigs; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Kinetics; Ranitidine; Structure-Activity Relationship; Thiazoles	1981
Inhibition of microsomal drug metabolism by histamine H2-receptor antagonists studied in vivo and in vitro in rodents. Gastroenterology, 1982, Volume: 82, Issue:1 Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Breath Tests; Cimetidine; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Furans; Guanidines; Histamine H2 Antagonists; Male; Mice; Mice, Inbred ICR; Microsomes, Liver; Ranitidine; Rats; Rats, Inbred Strains; Thiazoles; Time Factors	1982
Effect of some new Histamine H2-receptor antagonists on the guinea-pig papillary muscle. Naunyn-Schmiedeberg's archives of pharmacology, 1981, Volume: 317, Issue:3 Topics: Animals; Cimetidine; Furans; Guanidines; Guinea Pigs; Histamine Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Myocardial Contraction; Papillary Muscles; Ranitidine; Thiazoles	1981
Histamine H1- and muscarinic receptor antagonist activity of cimetidine and tiotidine in the guinea pig isolated ileum. Agents and actions, 1981, Volume: 11, Issue:6-7 Topics: Animals; Carbachol; Cimetidine; Guanidines; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Thiazoles	1981
Interaction of histamine with gastric mucosal cells. Effect of histamine H2 antagonists on binding and biological response. Molecular pharmacology, 1982, Volume: 22, Issue:1 Topics: Animals; Cimetidine; Cyclic AMP; Furans; Gastric Mucosa; Guanidines; Guinea Pigs; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Ranitidine; Receptors, Histamine; Thiazoles	1982
A comparison of some of the pharmacological properties of etintidine, a new histamine H2-receptor antagonist, with those of cimetidine, ranitidine and tiotidine. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 224, Issue:1 Topics: Adrenergic beta-Antagonists; Animals; Cimetidine; Dogs; Female; Furans; Gastric Juice; Guanidines; Guinea Pigs; Heart Rate; Histamine H1 Antagonists; Histamine H2 Antagonists; Imidazoles; In Vitro Techniques; Male; Myocardial Contraction; Parasympatholytics; Ranitidine; Rats; Rats, Inbred Strains; Thiazoles; Uterine Contraction	1983
The role of antagonists to acid secretion. Comprehensive therapy, 1982, Volume: 8, Issue:12 Topics: 16,16-Dimethylprostaglandin E2; Benzodiazepinones; Cimetidine; Furans; Gastric Acid; Gastrointestinal Diseases; Guanidines; Histamine H2 Antagonists; Humans; Pirenzepine; Proglumide; Ranitidine; Somatostatin; Thiazoles	1982
Dose-response curve analysis of gastric secretory responses in the dog and man to impromidine: a new histamine-H2-receptor agonist. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 225, Issue:1 Topics: Adult; Animals; Binding, Competitive; Cimetidine; Dogs; Dose-Response Relationship, Drug; Female; Gastric Acid; Guanidines; Histamine H2 Antagonists; Humans; Imidazoles; Impromidine; Receptors, Histamine; Receptors, Histamine H2; Thiazoles	1983
Negative inotropic effect of some H2-receptor antagonists on the isolated human atria. Experientia, 1983, Nov-15, Volume: 39, Issue:11 Topics: Calcium; Cimetidine; Depression, Chemical; Dose-Response Relationship, Drug; Heart Atria; Histamine H2 Antagonists; Humans; Imidazoles; Myocardial Contraction; Pyrimidinones; Verapamil	1983
Histamine H2 receptor antagonists. 1. Synthesis of N-cyano and N-carbamoyl amidine derivatives and their biological activities. Journal of medicinal chemistry, 1984, Volume: 27, Issue:7 Topics: Amidines; Animals; Carbamates; Cimetidine; Dogs; Histamine; Histamine H2 Antagonists; Nitriles; Ranitidine; Structure-Activity Relationship	1984
Genetic heterogeneity of histamine H2-receptors in the mouse vas deferens. British journal of pharmacology, 1984, Volume: 83, Issue:3 Topics: Animals; Calcium; Cimetidine; Electric Stimulation; Genetic Variation; Histamine H2 Antagonists; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Receptors, Histamine; Receptors, Histamine H2; Species Specificity; Vas Deferens	1984
A radioimmunoassay for the histamine H2-antagonist, tiotidine. Agents and actions, 1984, Volume: 15, Issue:3-4 Topics: Animals; Cimetidine; Dogs; Gastric Acid; Histamine; Histamine H2 Antagonists; Radioimmunoassay	1984
Pathologic findings in the stomachs of rats treated with the H2-receptor antagonist tiotidine. Scandinavian journal of gastroenterology. Supplement, 1984, Volume: 101 Topics: Animals; Atrophy; Cimetidine; Female; Histamine H2 Antagonists; Male; Parietal Cells, Gastric; Pylorus; Rats; Rats, Inbred Strains; Stomach; Stomach Neoplasms; Time Factors	1984
Interaction of alpha-adrenergic imidazolines with cardiac histamine H2-receptors. European journal of pharmacology, 1981, May-08, Volume: 71, Issue:2-3 Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Guanidines; Guinea Pigs; Heart; Heart Rate; Histamine Release; Imidazoles; In Vitro Techniques; Male; Myocardial Contraction; Receptors, Histamine; Receptors, Histamine H2; Stereoisomerism; Sympathomimetics; Tetrahydronaphthalenes; Thiazoles; Tolazoline	1981
A species comparison of the histamine H2-receptor on mast cells and basophils. Agents and actions, 1982, Volume: 12, Issue:3 Topics: Animals; Basophils; Cimetidine; Female; Furans; Guanidines; Guinea Pigs; Histamine H2 Antagonists; Histamine Release; Humans; In Vitro Techniques; Lung; Male; Mast Cells; Ranitidine; Rats; Receptors, Histamine; Receptors, Histamine H2; Species Specificity; Thiazoles	1982
Histamine H2 receptor desensitization in HL-60 human promyelocytic leukemia cells. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 231, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Cell Differentiation; Cell Line; Cimetidine; Cyclic AMP; Dimaprit; Dinoprostone; Dose-Response Relationship, Drug; Histamine; Humans; Leukemia, Myeloid, Acute; Prostaglandins E; Receptors, Histamine; Receptors, Histamine H2; Thiocarbamates; Thiourea	1984
Pharmacological interactions between ranitidine, cimetidine, metiamide and tiotidine at histamine H2-receptor sites in guinea-pig atria. Agents and actions, 1982, Volume: 12, Issue:1-2 Topics: Animals; Cimetidine; Dimaprit; Drug Interactions; Furans; Guanidines; Guinea Pigs; Heart; Heart Rate; Histamine; In Vitro Techniques; Metiamide; Ranitidine; Receptors, Histamine; Receptors, Histamine H2; Thiazoles; Thiourea	1982
Histamine H2-binding studies in the guinea-pig brain. Agents and actions, 1984, Volume: 14, Issue:3-4 Topics: Animals; Brain Chemistry; Cimetidine; Female; Guinea Pigs; Male; Pyrilamine; Radioligand Assay; Receptors, Histamine; Receptors, Histamine H2; Tritium	1984
Structural and functional analysis of the canine histamine H2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action. The Biochemical journal, 1995, Sep-01, Volume: 310 ( Pt 2) Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Amino Acid Sequence; Animals; Asparagine; Base Sequence; Binding, Competitive; Calcium; Cell Line; Cell Membrane; Chlorocebus aethiops; CHO Cells; Cimetidine; Cloning, Molecular; Codon; Cricetinae; Cyclic AMP; Dogs; Dose-Response Relationship, Drug; Glycosylation; GTP-Binding Proteins; Histamine; Histamine H2 Antagonists; Immunoblotting; Kidney; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Point Mutation; Protein Structure, Secondary; Receptors, Histamine H2; Recombinant Proteins; Transfection	1995
R-alpha-methylhistamine-induced inhibition of gastric acid secretion in pylorus-ligated rats via central histamine H3 receptors. British journal of pharmacology, 1995, Volume: 115, Issue:7 Topics: Animals; Cimetidine; Female; Gastric Acid; Gastric Mucosa; Histamine Agonists; Histamine Antagonists; Injections, Intraventricular; Methylhistamines; Piperidines; Pylorus; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine H3	1995
Homologous desensitization of histamine H2 receptors in the human gastric carcinoma cell line MKN-45. The American journal of physiology, 1993, Volume: 265, Issue:5 Pt 1 Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cimetidine; Colforsin; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Histamine; Histamine H2 Antagonists; Humans; Kinetics; Receptors, Histamine H2; Sodium Fluoride; Stomach Neoplasms; Tumor Cells, Cultured	1993
[Studies on histamine H2-receptor antagonistic property of FRG-8813, a novel anti-ulcer drug]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1995, Volume: 105, Issue:4 Topics: Acetamides; Aminopyrine; Animals; Cerebral Cortex; Cimetidine; Dose-Response Relationship, Drug; Gastric Mucosa; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Male; Myocardial Contraction; Piperidines; Pyridines; Stimulation, Chemical; Time Factors	1995
Histamine H2 receptors and histidine decarboxylase in normal and leukemic human monocytes and macrophages. The American journal of physiology, 1994, Volume: 267, Issue:2 Pt 2 Topics: Adenylyl Cyclases; Binding Sites; Cimetidine; Cyclic AMP; Enzyme Activation; Gene Expression; Histamine; Histamine H2 Antagonists; Histidine Decarboxylase; Humans; Hydrogen Peroxide; Leukemia; Macrophages; Macrophages, Alveolar; Monocytes; Receptors, Histamine H1; Reference Values; Tumor Cells, Cultured	1994
Expression of histamine H2 receptor in Chinese hamster ovary cells: a probe to study the desensitization mechanism. Journal of gastroenterology, 1994, Volume: 29 Suppl 7 Topics: Animals; CHO Cells; Cimetidine; Cricetinae; Cyclic AMP; Dogs; Histamine; Histamine H2 Antagonists; Receptors, Histamine H2; Transfection	1994
Histamine-induced modulation of nociceptive responses. Pain, 1994, Volume: 58, Issue:1 Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Mesencephalon; Microinjections; Naloxone; Nociceptors; Pain Measurement; Periaqueductal Gray; Pyrimidinones; Raphe Nuclei; Rats; Rats, Sprague-Dawley	1994
Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy] propyl] urea. Arzneimittel-Forschung, 1993, Volume: 43, Issue:2 Topics: Animals; Cerebral Cortex; Cimetidine; Dogs; Famotidine; Food; Gastric Acid; Guinea Pigs; Heart Atria; Heart Rate; Histamine H2 Antagonists; In Vitro Techniques; Kinetics; Male; Phenylurea Compounds; Piperidines; Pylorus; Rats; Rats, Wistar; Tetragastrin	1993
Increase of human platelet serotonin uptake by atypical histamine receptors. The American journal of physiology, 1994, Volume: 266, Issue:2 Pt 2 Topics: Adult; Aminoquinolines; Biological Transport; Blood Platelets; Cimetidine; Cyclic AMP; Dimaprit; Famotidine; Female; Histamine Antagonists; Histidine; Humans; Imipramine; Impromidine; In Vitro Techniques; Male; Metiamide; Middle Aged; Models, Biological; Platelet Aggregation; Receptors, Histamine; Serotonin	1994
Histamine H2 receptor mediates keratan sulfate secretion in rabbit chondrocytes: role of cAMP. The American journal of physiology, 1993, Volume: 265, Issue:6 Pt 1 Topics: Animals; Bucladesine; Cartilage, Articular; Cells, Cultured; Cholera Toxin; Cimetidine; Colforsin; Cyclic AMP; Dimaprit; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Keratan Sulfate; Kinetics; Methylhistamines; Parathyroid Hormone; Proteoglycans; Rabbits; Receptors, Histamine H2; Sulfates; Sulfur Radioisotopes	1993
Desensitization of canine histamine H2 receptor expressed in Chinese hamster ovary cells. Biochemical and biophysical research communications, 1993, Feb-15, Volume: 190, Issue:3 Topics: Adenylyl Cyclases; Animals; Bucladesine; Cell Membrane; CHO Cells; Cimetidine; Cricetinae; Dogs; Down-Regulation; Histamine; In Vitro Techniques; Receptors, Histamine H2; Recombinant Proteins; Transfection	1993
Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin. European journal of pharmacology, 1996, Jan-25, Volume: 296, Issue:2 Topics: Animals; Cerebral Cortex; Cimetidine; Guanosine 5'-O-(3-Thiotriphosphate); Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Male; Methylhistamines; Pertussis Toxin; Protein Binding; Pyrilamine; Radioligand Assay; Rats; Receptors, Histamine H3; Sulfur Radioisotopes; Virulence Factors, Bordetella	1996
Action of ebrotidine, ranitidine and cimetidine on the specific binding to histamine H1- and H2-receptors. Arzneimittel-Forschung, 1997, Volume: 47, Issue:4A Topics: Animals; Benzenesulfonates; Cell Membrane; Cerebellum; Cerebral Cortex; Cimetidine; Depression, Chemical; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Isotope Labeling; Male; Protein Binding; Pyrilamine; Ranitidine; Receptors, Histamine H1; Receptors, Histamine H2; Thiazoles; Tritium	1997
Role of the C terminus in histamine H2 receptor signaling, desensitization, and agonist-induced internalization. The Journal of biological chemistry, 1997, Aug-01, Volume: 272, Issue:31 Topics: Amino Acid Sequence; Animals; Cimetidine; COS Cells; Cyclic AMP; Histamine Agonists; Molecular Sequence Data; Receptors, Histamine H2; Structure-Activity Relationship	1997
Atypical association of H1 and H2 histamine receptors with signal transduction pathways during multistage mouse skin carcinogenesis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46, Issue:8 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Count; Cimetidine; Cyclic AMP; Female; Histamine H1 Antagonists; Histamine H2 Antagonists; Hydrolysis; Mast Cells; Mice; Phosphatidylinositols; Pyrilamine; Receptors, Histamine H1; Receptors, Histamine H2; Second Messenger Systems; Signal Transduction; Skin Neoplasms; Tetradecanoylphorbol Acetate	1997
Substituted pyrido[3,2-b]oxazin-3(4H)-ones: synthesis and evaluation of antinociceptive activity. Bioorganic & medicinal chemistry, 1998, Volume: 6, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Cimetidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Histamine Antagonists; Male; Mice; Models, Chemical; Nociceptors; Oxazines; Pyridines; Pyrilamine; Pyrrolidines; Receptors, Opioid; Structure-Activity Relationship	1998
Histamine receptors in human epithelial cells--characterization of the receptor G-protein-effector system. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1 Topics: Breast; Cell Line; Cimetidine; Epithelial Cells; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Histamine H1 Antagonists; Histamine H2 Antagonists; Humans; Inositol; Models, Theoretical; Phosphatidylinositols; Pyrilamine; Radioligand Assay; Receptors, Cell Surface; Receptors, Histamine	1998
Tiotidine, a classical H2-antagonist, presents characteristics of an inverse agonist in U937 cell line. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1 Topics: Cimetidine; Cyclic AMP; Dose-Response Relationship, Drug; Guanidines; Histamine Agonists; Histamine H2 Antagonists; Humans; Imidazoles; Lymphoma, Large B-Cell, Diffuse; Receptors, Histamine H2; Tumor Cells, Cultured	1998
Histamine receptors signalling in epidermal tumor cell lines with H-ras gene alterations. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cimetidine; Cyclic AMP; Gene Expression Regulation, Neoplastic; Genes, ras; Histamine Agonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Inositol Phosphates; Keratinocytes; Mice; Mutation; Oncogene Protein p21(ras); Pyrilamine; Receptors, Histamine; Second Messenger Systems; Signal Transduction; Tumor Cells, Cultured	1998
Characterization of the histamine H2 receptor structural components involved in dual signaling. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:2 Topics: Adenylyl Cyclases; Animals; Cimetidine; Dogs; Histamine; Peptide Fragments; Receptors, Histamine H2; Signal Transduction; Type C Phospholipases	1998
Combined histamine H1/H2 receptor antagonists: part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1998, Volume: 6, Issue:3 Topics: Animals; Atrial Function; Cimetidine; Guinea Pigs; Heart Atria; Histamine H1 Antagonists; Histamine H2 Antagonists; Ileum; In Vitro Techniques; Pheniramine; Structure-Activity Relationship	1998
Roles of histamine receptor in a guinea pig asthma model. International journal of immunopharmacology, 1998, Volume: 20, Issue:10 Topics: Animals; Asthma; Cimetidine; Disease Models, Animal; Guinea Pigs; Histamine Antagonists; Lung; Male; Pyrilamine; Radioligand Assay; Receptors, Histamine H1; Receptors, Histamine H2	1998
Molecular properties of central and peripheral histamine H1 and H2 receptors. Pflugers Archiv : European journal of physiology, 2000, Volume: 439, Issue:3 Suppl Topics: Animals; Astrocytes; Binding, Competitive; Cattle; Cells, Cultured; Cerebral Cortex; Cimetidine; Endothelium, Vascular; Histamine H1 Antagonists; Histamine H2 Antagonists; Muscle, Smooth, Vascular; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine H1; Receptors, Histamine H2	2000
Long-lasting binding of IT-066 to human histamine H2 receptor. Digestive diseases and sciences, 2000, Volume: 45, Issue:4 Topics: Animals; Anti-Ulcer Agents; CHO Cells; Cimetidine; Cricetinae; Cyclic AMP; Famotidine; Fixatives; Formaldehyde; Histamine H2 Antagonists; Piperidines; Polymers; Protein Binding; Pyridines; Ranitidine; Receptors, Histamine H2	2000
Rapid desensitization and slow recovery of the cyclic AMP response mediated by histamine H(2) receptors in the U937 cell line. Biochemical pharmacology, 2000, Jul-15, Volume: 60, Issue:2 Topics: beta-Adrenergic Receptor Kinases; Cimetidine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Guanidines; Histamine Agonists; Histamine H2 Antagonists; Humans; Imidazoles; Phosphoric Diester Hydrolases; Radioligand Assay; Receptors, Histamine H2; Tritium; U937 Cells	2000
Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Immunology letters, 2001, Apr-02, Volume: 76, Issue:3 Topics: Antigens, CD; Biomarkers; Cell Differentiation; Cell Membrane; Cells, Cultured; Cimetidine; Dendritic Cells; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Histidine Decarboxylase; Humans; Triprolidine	2001
Similar apparent constitutive activity of human histamine H(2)-receptor fused to long and short splice variants of G(salpha). The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:3 Topics: Alternative Splicing; Animals; Cell Membrane; Cells, Cultured; Cimetidine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gs; Guanidine; Guanosine 5'-O-(3-Thiotriphosphate); Histamine Agonists; Histamine H2 Antagonists; Humans; Insecta; Radioligand Assay; Receptors, Histamine H2; Recombinant Fusion Proteins; Sulfur Radioisotopes; Transfection; Tritium	2001
Histamine deficiency induces tissue-specific down-regulation of histamine H2 receptor expression in histidine decarboxylase knockout mice. FEBS letters, 2001, Nov-16, Volume: 508, Issue:2 Topics: Animals; Cimetidine; Down-Regulation; Gene Deletion; Gene Expression Profiling; Histamine; Histidine Decarboxylase; Mice; Mice, Knockout; Organ Specificity; Receptors, Histamine H2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2001
Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists. Molecular pharmacology, 2001, Volume: 60, Issue:6 Topics: Alternative Splicing; Amino Acid Sequence; Animals; Binding Sites; Cell Membrane; Cells, Cultured; Cimetidine; GTP-Binding Protein alpha Subunits, Gs; Guanidine; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Histamine Agonists; Humans; Insecta; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Conformation; Protein Isoforms; Ranitidine; Receptors, Histamine H2; Sequence Homology, Amino Acid; Species Specificity; Structure-Activity Relationship; Sulfur Radioisotopes; Tritium	2001
Potent and long-lasting action of lafutidine on the human histamine H(2) receptor. Digestion, 2001, Volume: 64, Issue:3 Topics: Acetamides; Animals; CHO Cells; Cimetidine; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Famotidine; Histamine H2 Antagonists; Humans; Piperidines; Pyridines; Receptors, Histamine H2; Transfection	2001
Characterization of histamine H(2)-like receptors in duck cerebral cortical membranes by [(3)H]tiotidine binding. Neuroscience letters, 2002, Feb-22, Volume: 319, Issue:3 Topics: Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Cimetidine; Ducks; Female; Histamine H2 Antagonists; Ligands; Male; Membranes; Receptors, Histamine H2; Tritium	2002
G649, an allelic variant of the human H2 receptor with low basal activity, is resistant to upregulation upon antagonist exposure. The pharmacogenomics journal, 2001, Volume: 1, Issue:1 Topics: Alleles; Animals; CHO Cells; Cimetidine; Cricetinae; Cyclic AMP; Histamine; Histamine H2 Antagonists; Humans; Mutation; Receptors, Histamine H2; Up-Regulation	2001
Effects of N-alpha-methyl-histamine on human H(2) receptors expressed in CHO cells. Gut, 2002, Volume: 50, Issue:6 Topics: Animals; CHO Cells; Cimetidine; Cricetinae; Cyclic AMP; Famotidine; Female; Histamine Agonists; Histamine Antagonists; Histamine H2 Antagonists; Methylhistamines; Ovary; Piperidines; Receptors, Histamine H2; Receptors, Histamine H3	2002
Mouse mammary epithelial cells bear histamine receptors. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51 Suppl 1 Topics: Animals; Binding Sites; Cimetidine; Epithelial Cells; Female; Histamine Agonists; Histamine H1 Antagonists; Histamine H2 Antagonists; Mammary Glands, Animal; Methylhistamines; Mice; Mice, Inbred BALB C; Pyrilamine; Radiopharmaceuticals; Receptors, Histamine	2002
The initial inositol 1,4,5-trisphosphate response induced by histamine is strongly amplified by Ca(2+) release from internal stores in smooth muscle. Cell calcium, 2002, Volume: 31, Issue:4 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Androstadienes; Animals; Calcium; Carbachol; Cimetidine; Extracellular Space; Guinea Pigs; Histamine; Histamine Agonists; Inositol 1,4,5-Trisphosphate; Kinetics; Lithium; Muscle, Smooth; Pyrilamine; Ryanodine; Thapsigargin; Type C Phospholipases; Urinary Bladder; Wortmannin	2002
Regulation of phospholipase C activation by the number of H(2) receptors during Ca(2+)-induced differentiation of mouse keratinocytes. Biochemical pharmacology, 2002, May-15, Volume: 63, Issue:10 Topics: Animals; Binding Sites; Blotting, Northern; Calcium; Cell Differentiation; Cells, Cultured; Cimetidine; Cyclic AMP; Enzyme Activation; Histamine; Histamine H2 Antagonists; Histidine Decarboxylase; Keratinocytes; Mice; Receptors, Histamine H2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tritium; Type C Phospholipases	2002
Histamine H(2) -like receptors in chick cerebral cortex: effects on cyclic AMP synthesis and characterization by [(3) H]tiotidine binding. Journal of neurochemistry, 2002, Volume: 81, Issue:5 Topics: Adenylyl Cyclases; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Chickens; Cimetidine; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Guinea Pigs; Histamine; Histamine Agonists; Histamine Antagonists; Male; Radioligand Assay; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3	2002
Histamine H1 receptors in rat dorsal raphe nucleus: pharmacological characterisation and linking to increased neuronal activity. Brain research, 2002, Nov-08, Volume: 954, Issue:2 Topics: Action Potentials; Animals; Brain Stem; Cimetidine; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Inositol Phosphates; Male; Neurons; Pyrilamine; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Histamine H1; Serotonin	2002
Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model. Molecular pharmacology, 2003, Volume: 64, Issue:2 Topics: Animals; Cimetidine; COS Cells; Dose-Response Relationship, Drug; Histamine Agonists; Histamine H2 Antagonists; Humans; Models, Biological; Receptors, Histamine H2; Transfection; Tritium; Tumor Cells, Cultured; U937 Cells	2003
Effects of cimetidine-like drugs on recombinant GABAA receptors. Life sciences, 2004, Oct-08, Volume: 75, Issue:21 Topics: Cell Line; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Fibroblasts; Histamine H2 Antagonists; Humans; Patch-Clamp Techniques; Ranitidine; Receptors, GABA-A; Recombinant Proteins	2004
Mechanisms of inverse agonism at histamine H(2) receptors - potential benefits and concerns. Inflammopharmacology, 2006, Volume: 14, Issue:1-2 Topics: Animals; Cimetidine; Histamine Agonists; Histamine H2 Antagonists; Humans; Ligands; Receptors, Histamine H2	2006
Synthesis and dual histamine H₁ and H₂ receptor antagonist activity of cyanoguanidine derivatives. Molecules (Basel, Switzerland), 2013, Nov-15, Volume: 18, Issue:11 Topics: Animals; Cimetidine; Guanidines; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Piperidines; Pyrilamine	2013