Page last updated: 2024-08-16

tiopronin and thiorphan

tiopronin has been researched along with thiorphan in 105 studies

Research

Studies (105)

Timeframe	Studies, this research(%)	All Research%
pre-1990	101 (96.19)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (0.95)	29.6817
2010's	3 (2.86)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brimacombe, KR; Dulcey, AE; Goldsborough, AS; Gottesman, MM; Griffiths, G; Hall, MD; Handley, MD; Kannan, P; Pluchino, KM	1
Cuesta-Bernal, J; El-Delik, J; Frank, D; Göttig, S; Klingler, FM; Koenigs, A; Müller, HF; Pogoryelov, D; Pos, KM; Proschak, E; Sjuts, H; Wichelhaus, TA	2
Kehl, LJ	1
Borson, DB; Caughey, G; Corrales, R; Gold, M; Nadel, JA; Ramachandran, J; Varsano, S; Viro, N	1
Stimler-Gerard, NP	1
Benoliel, JJ; Berthier, JL; Bourgoin, S; Cesselin, F; Hamon, M; Hirsch, M; Mauborgne, A	1
Borson, DB; Nadel, JA; Sekizawa, K; Tamaoki, J	1
Basbaum, CB; Borson, DB; Graf, PD; Nadel, JA; Sekizawa, K; Tamaoki, J	1
Coats, SR; Drazen, JM; Shore, SA; Stimler-Gerard, NP	1
Tseng, LF	1
Livett, BG; Marley, PD; Mitchelhill, KI	1
Dzoljic, MR; Haffmans, J; van Amsterdam, JC; Walsum, MV	1
Cohen, ML; Evans, DA; Frederickson, RC; Mendelsohn, LG; Scott, WL	1
Cadden, S; Chitour, D; Le Bars, D; Villanueva, L	1
Roques, BP	1
Autry, WL; Barbaz, BS; Norman, JA	1
Aoki, K; Kajiwara, M; Oka, T	2
Fanciullacci, M; Geppetti, P; Lecomte, JM; Michelacci, S; Sicuteri, F; Spillantini, MG	1
Kalivas, PW; Richardson-Carlson, R	1
Ernst, M; Roby, A; Willer, JC	1
Federigo, S; Grazia, SM; Marcello, F; Sergio, M	1
Basilico, L; Giagnoni, G; Gori, E; Mennuni, L; Parolaro, D; Pecora, N	1
Buéno, L; Fioramonti, J	1
Giros, B; Gros, C; Llorens-Cortes, C; Schwartz, JC	1
Borson, DB; Jacoby, DB; Nadel, JA; Tamaoki, J	1
Costentin, J; Giros, B; Michael-Titus, A; Preterre, P	1
Martinez, JL; Walker, RC; Weinberger, SB; Zafuto, CE	1
Gros, C; Llorens-Cortes, C; Schwartz, JC	2
Bourgoin, S; Cesselin, F; Dickenson, AH; Fournié-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP	1
Dzoljic, MR	1
Livingston, SJ; Rooney, KF; Sewell, RD; Smith, HJ	1
Buéno, L; Liberge, M; Rivière, PM	1
De la Baume, S; Schwartz, JC	1
Borson, DB; Dusser, DJ; Graf, PD; Nadel, JA; Sekizawa, K	1
Hill, RG; Hughes, J; Pittaway, KM	1
Aoyagi, T; Hachisu, M; Hiranuma, T; Murata, S; Umezawa, H	1
Buéno, L; Rivière, PJ	1
Kameyama, T; Katoh, A; Nabeshima, T	1
Fukaya, H; Furukawa, H; Hiramatsu, M; Kameyama, T; Nabeshima, T	1
Charpentier, B; Durieux, C; Pelaprat, D; Roques, BP	1
Artaud, F; Bouboutou, R; Bourgoin, S; Cesselin, F; Clot, AM; Fournie-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP	1
Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H	1
Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF	1
Benchetrit, T; Fournié-Zaluski, MC; Roques, BP	1
Costentin, J; Danvy, D; Duhamel, L; Duhamel, P; Giros, B; Gros, C; Lecomte, JM; Plaquevent, JC; Schwartz, JC; Vlaiculescu, A	1
Costentin, J; Lecomte, JM; Marçais-Collado, H; Schwartz, JC; Uchida, G	1
Han, JS; Jin, WQ; Zhou, ZF	2
Devin, J; Fournié-Zaluski, MC; Lucas-Soroca, E; Roques, BP	1
Chaillet, P; Costentin, J; Leboyer, M; Lecomte, JM; Llorens-Cortes, C; Marcais-Collado, H; Schwartz, JC; Vlaiculescu, A	1
Hiranuma, T; Oka, T	1
Coquerel, A; Costentin, J; Dubuc, I; Kitabgi, P; Menard, JF	1
Bouthenet, ML; De la Baume, S; Pollard, H; Ronco, P; Schwartz, JC; Verroust, P	1
Dzoljic, MR; Haffmans, J	1
Anadón, A; Martinez-Larrañaga, MR	1
Bouboutou, R; Bourgoin, S; Cesselin, F; Devin, J; Fournie-Zaluski, MC; Hamon, M; Roques, B; Waksman, G	1
Beckman, AL; Sartin, NF; Stanton, TL	1
Han, JS; Yuan, H	1
Buéno, L; Fargeas, MJ; Fioramonti, J	1
Frederickson, RC; Johnson, BG; Mendelsohn, LG; Scott, WL	1
Bouboutou, R; Chaillet, P; Costentin, J; Coulaud, A; Devin, J; Fournié-Zaluski, MC; Roques, BP; Waksman, G	1
Deschodt-Lanckman, M	1
Besselievre, R; Bouboutou, R; Devin, J; Fournie-Zaluski, MC; Roques, BP; Waksman, G	1
Hachisu, M; Hiranuma, T; Murata, S; Shibazaki, Y; Takahashi, H	1
Chaillet, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Zajac, JM	1
Bean, AJ; Vaught, JL	1
Chou, J; Costa, E; Del Rio, J; Tang, J; Yang, HY	1
Cohen, ML; Geary, LE; Scott, WL; Wiley, KS	1
Chaillet, P; Costentin, J; Fournié-Zaluski, MC; Lucas-Soroca, E; Roques, BP	1
Checler, F; Kitabgi, P; Vincent, JP	1
Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP	1
Brandt, U; Lentzen, H; Palenker, J	1
Amano, H; Kaneko, S; Morimoto, Y; Takagi, H	1
Lentzen, H; Palenker, J	1
Chaillet, P; Costentin, J; de la Baume, S; Marcais-Collado, H; Schwartz, JC; Yi, CC	2
Baum, T; Becker, FT; Desiderio, DM; Sabin, C; Sybertz, EJ	1
Benoist, JM; Gautron, M; Guilbaud, G; Kayser, V	1
Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A	2
Billard, W; Chipkin, RE; Kreutner, W	1
Bouboutou, R; Chaillet, P; Cherot, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Waksman, G	1
Checler, F; Emson, PC; Kitabgi, P; Vincent, JP	1
Almenoff, J; Orlowski, M	1
de la Baume, S; Giros, B; Gros, C; Schwartz, JC	1
Guilbaud, G; Kayser, V	1
Soudijn, W; van Amsterdam, JG; van Buuren, KJ	1
Chaillet, P; Costentin, J; Lecomte, JM; Marçais, H; Natan, LB; Uchida, G	1
Giovino, AA; Glimcher, PW; Hoebel, BG; Margolin, DH	1
de Groat, WC; Hisamitsu, T	1
Chipkin, RE; O'Connor, P	1
Llorens-Cortes, C; Schwartz, JC	1
Costa, E; Yang, HY; Zhang, AZ	1
Barnett, A; Berger, J; Billard, W; Chipkin, RE; Iorio, LC	1
Costa, E; Harsing, LG; Majane, EM; Yang, HY	1
Wood, PL	1
Barnett, A; Chipkin, RE; Iorio, LC; Latranyi, MZ	1
Fournié-Zaluski, MC; Lecomte, JM; Llorens, C; Malfroy, B; Roques, BP; Schwartz, JC; Soroca, E	1
De La Baume, S; Fournie-Zaluski, MC; Gros, C; Patey, G; Roques, B; Schwartz, JC; Soroca-Lucas, E	1
Harty, GJ; Yaksh, TL	1
Fulcher, IS; Kenny, AJ; Matsas, R; Turner, AJ	1
Chew, GH; Lowe, EW; McIntyre, NR; Merkler, DJ; Owen, TC	1

Reviews

2 review(s) available for tiopronin and thiorphan

Article	Year
[Enkephalinase inhibitors and molecular study of the differences between active sites of enkephalinase and angiotensin-converting enzyme]. Journal de pharmacologie, 1985, Volume: 16 Suppl 1 Topics: Analgesics; Animals; Binding Sites; Drug Synergism; Endopeptidases; Enkephalins; Humans; Metalloendopeptidases; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Sulfhydryl Compounds; Thiorphan; Tiopronin	1985
Enkephalins, other endogenous opioids and colonic motility in dog and man. Gastroenterologie clinique et biologique, 1987, Volume: 11, Issue:3 Pt 2 Topics: Animals; Central Nervous System; Colon; Dogs; Endorphins; Enkephalins; Gastrointestinal Motility; Humans; In Vitro Techniques; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Species Specificity; Thiorphan; Tiopronin	1987

Article

Year

[Enkephalinase inhibitors and molecular study of the differences between active sites of enkephalinase and angiotensin-converting enzyme].

Journal de pharmacologie, 1985, Volume: 16 Suppl 1

Topics: Analgesics; Animals; Binding Sites; Drug Synergism; Endopeptidases; Enkephalins; Humans; Metalloendopeptidases; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Sulfhydryl Compounds; Thiorphan; Tiopronin

1985

Enkephalins, other endogenous opioids and colonic motility in dog and man.

Gastroenterologie clinique et biologique, 1987, Volume: 11, Issue:3 Pt 2

Topics: Animals; Central Nervous System; Colon; Dogs; Endorphins; Enkephalins; Gastrointestinal Motility; Humans; In Vitro Techniques; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Species Specificity; Thiorphan; Tiopronin

1987

Other Studies

103 other study(ies) available for tiopronin and thiorphan

Article	Year
Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin. Journal of medicinal chemistry, 2011, Jul-28, Volume: 54, Issue:14 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Multidrug Resistance-Associated Proteins; Orphan Drug Production; Paclitaxel; RNA Stability; RNA, Messenger; Structure-Activity Relationship; Tiopronin	2011
Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria. Journal of medicinal chemistry, 2015, Apr-23, Volume: 58, Issue:8 Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Crystallography, X-Ray; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Humans; Imipenem; Klebsiella Infections; Klebsiella pneumoniae; Models, Molecular; Pseudomonas aeruginosa; Pseudomonas Infections; Sulfhydryl Compounds	2015
Correction to Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria. Journal of medicinal chemistry, 2015, Aug-13, Volume: 58, Issue:15 Topics:	2015
Analgesia after inhibition of enkephalin degradation. Journal of the American Dental Association (1939), 1986, Volume: 112, Issue:2 Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Naloxone; Neprilysin; Protease Inhibitors; Spinal Cord; Substance P; Thiorphan; Tiopronin	1986
Enkephalinase inhibitors potentiate substance P-induced secretion of 35SO4-macromolecules from ferret trachea. Experimental lung research, 1987, Volume: 12, Issue:1 Topics: Animals; Drug Synergism; Endopeptidases; Enkephalin, Methionine; Ferrets; Glycopeptides; In Vitro Techniques; Male; Molecular Weight; Mucus; Neprilysin; Protease Inhibitors; Rabbits; Substance P; Sulfates; Thiorphan; Tiopronin; Trachea	1987
Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung. The Journal of clinical investigation, 1987, Volume: 79, Issue:6 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Complement C3; Complement C3a; Complement C5; Complement C5a; Drug Interactions; Endopeptidases; Glycopeptides; Guinea Pigs; Lung; Muscle Contraction; N-Formylmethionine Leucyl-Phenylalanine; Peptidyl-Dipeptidase A; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Thiorphan; Tiopronin; Trachea	1987
Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2 Topics: Animals; Captopril; Dipeptides; In Vitro Techniques; Leucine; Male; Metalloendopeptidases; Naloxone; Neprilysin; Oligopeptides; Peptidyl-Dipeptidase A; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Thiorphan; Tiopronin	1987
Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea. Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 63, Issue:4 Topics: Airway Resistance; Amino Acids, Sulfur; Animals; Electric Stimulation; Ferrets; In Vitro Techniques; Metalloendopeptidases; Neprilysin; Substance P; Thiorphan; Tiopronin; Trachea	1987
Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3 Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Epithelium; Ferrets; In Vitro Techniques; Metalloendopeptidases; Muscle Contraction; Neprilysin; Neurokinin A; Neurokinin B; Neuropeptides; Substance P; Tachykinins; Thiorphan; Tiopronin; Trachea	1987
Substance P-induced bronchoconstriction in the guinea pig. Enhancement by inhibitors of neutral metalloendopeptidase and angiotensin-converting enzyme. The American review of respiratory disease, 1988, Volume: 137, Issue:2 Topics: Amino Acids, Sulfur; Angiotensin-Converting Enzyme Inhibitors; Animals; Bronchi; Captopril; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Male; Methacholine Chloride; Methacholine Compounds; Plethysmography, Whole Body; Protease Inhibitors; Respiration, Artificial; Substance P; Thiorphan; Time Factors; Tiopronin	1988
Release of a dynorphin A (1-8) degrading enzyme from the spinal cord by intraventricular morphine in the rat. Life sciences, 1988, Volume: 42, Issue:13 Topics: Animals; Aprotinin; Bacitracin; Binding, Competitive; Dynorphins; Injections, Intraventricular; Kinetics; Male; Morphine; Neuropeptides; Peptide Fragments; Peptide Hydrolases; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin	1988
Effects of opioid peptides containing the sequence of Met5-enkephalin or Leu5-enkephalin on nicotine-induced secretion from bovine adrenal chromaffin cells. Journal of neurochemistry, 1986, Volume: 46, Issue:1 Topics: Adenosine Triphosphate; Adrenal Medulla; Amino Acid Sequence; Animals; Bacitracin; Cattle; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guinea Pigs; Leucine; Nicotine; Norepinephrine; Peptide Fragments; Phenanthrolines; Rabbits; Receptors, Opioid; Thiorphan; Tiopronin	1986
Phelorphan, an inhibitor of enzymes involved in the biodegradation of enkephalins, affected the withdrawal symptoms in chronic morphine-dependent rats. Neuroscience, 1987, Volume: 22, Issue:1 Topics: Aminopeptidases; Animals; Brain; CD13 Antigens; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Male; Morphine Dependence; Naloxone; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome; Thiorphan; Tiopronin	1987
Enantiomers of [R,S]-thiorphan: dissociation of analgesia from enkephalinase A inhibition. Life sciences, 1985, Apr-01, Volume: 36, Issue:13 Topics: Amino Acids, Sulfur; Analgesics; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Guinea Pigs; Male; Mice; Neprilysin; Protease Inhibitors; Stereoisomerism; Thiorphan; Tiopronin	1985
Failure of ES 52, a highly potent enkephalinase inhibitor, to affect nociceptive transmission by rat dorsal horn convergent neurones. Brain research, 1985, Apr-29, Volume: 333, Issue:1 Topics: Amino Acids, Sulfur; Animals; Enkephalins; Male; Nociceptors; Pain; Rats; Spinal Cord; Synaptic Transmission; Thiorphan; Tiopronin	1985
Angiotensin-converting enzyme inhibitors potentiate the analgesic activity of [Met]-enkephalin-Arg6-Phe7 by inhibiting its degradation in mouse brain. Molecular pharmacology, 1985, Volume: 28, Issue:6 Topics: Analgesics; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain; Captopril; Enalapril; Enalaprilat; Enkephalin, Methionine; Hydrolysis; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Peptidyl-Dipeptidase A; Synaptic Membranes; Thiorphan; Tiopronin	1985
The inactivation of [Met5]-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens. Japanese journal of pharmacology, 1986, Volume: 40, Issue:2 Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Captopril; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Neprilysin; Peptidyl-Dipeptidase A; Phenylalanine; Thiorphan; Tiopronin; Vas Deferens	1986
In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF. European journal of pharmacology, 1986, Jun-05, Volume: 125, Issue:1 Topics: Amino Acids, Sulfur; Endopeptidases; Humans; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Thiorphan; Tiopronin	1986
Endogenous enkephalin modulation of dopamine neurons in ventral tegmental area. The American journal of physiology, 1986, Volume: 251, Issue:2 Pt 2 Topics: Animals; Behavior, Animal; Dopamine; Enkephalins; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Opioid; Tegmentum Mesencephali; Thiorphan; Tiopronin	1986
The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans. Neuropharmacology, 1986, Volume: 25, Issue:8 Topics: Adult; Amino Acids, Sulfur; Electric Stimulation; Endopeptidases; Enkephalins; Female; Humans; Male; Middle Aged; Neprilysin; Pain; Protease Inhibitors; Recruitment, Neurophysiological; Reflex; Spinal Cord; Sural Nerve; Synaptic Transmission; Thiorphan; Tiopronin	1986
Pharmacological "enkephalinase" inhibition in man. Advances in experimental medicine and biology, 1986, Volume: 198 Pt B Topics: Amino Acids, Sulfur; Captopril; Endopeptidases; Headache; Neprilysin; Peptidyl-Dipeptidase A; Phenylalanine; Protease Inhibitors; Stereoisomerism; Thiorphan; Tiopronin	1986
Binding studies of dermorphin and its L-form on rat brain opioid receptors. Pharmacological research communications, 1987, Volume: 19, Issue:2 Topics: Alanine; Animals; Binding, Competitive; Biological Assay; Brain; Captopril; Ileum; Leucine; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship; Thiorphan; Tiopronin	1987
[Opioid peptides: metabolism and receptors]. Gastroenterologie clinique et biologique, 1987, Volume: 11, Issue:3 Pt 2 Topics: Animals; Brain; Cattle; Endopeptidases; Endorphins; Enkephalins; Humans; Leucine; Mice; Neprilysin; Pro-Opiomelanocortin; Protease Inhibitors; Protein Precursors; Receptors, Opioid; Thiorphan; Tiopronin	1987
Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase. Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 64, Issue:6 Topics: Animals; Captopril; Disease Models, Animal; Ferrets; In Vitro Techniques; Influenza A virus; Leucine; Leupeptins; Metalloendopeptidases; Muscle Contraction; Muscle, Smooth; Neprilysin; Orthomyxoviridae Infections; Thiorphan; Tiopronin; Trachea	1988
Role of endogenous enkephalins in locomotion evidenced by acetorphan, an "enkephalinase" inhibitor. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3 Topics: Amino Acids, Sulfur; Animals; Dose-Response Relationship, Drug; Enkephalins; Hydroxydopamines; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thiorphan; Tiopronin	1987
Characterization of enkephalin degradation in rat plasma. NIDA research monograph, 1986, Volume: 75 Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Leucine; Enkephalins; Kinetics; Leucine; Male; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1986
Evaluation of striatal enkephalin release in vivo from steady state levels and turnover rates of the tripeptide Tyr-Gly-Gly. NIDA research monograph, 1986, Volume: 75 Topics: Animals; Anti-Bacterial Agents; Corpus Striatum; Enkephalins; In Vitro Techniques; Kinetics; Leucine; Male; Mice; Oligopeptides; Pentobarbital; Thiorphan; Tiopronin	1986
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord. NIDA research monograph, 1986, Volume: 75 Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain; Rats; Spinal Cord; Thiorphan; Tiopronin	1986
Enkephalinase inhibitors attenuate naloxone-precipitated withdrawal syndrome. NIDA research monograph, 1986, Volume: 75 Topics: Amino Acids, Sulfur; Animals; Cerebral Ventricles; Cerebrospinal Fluid; Dipeptides; Glycopeptides; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substance Withdrawal Syndrome; Thiorphan; Tiopronin	1986
Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan. Psychopharmacology, 1988, Volume: 94, Issue:4 Topics: Amino Acids, Sulfur; Analgesics; Animals; Body Temperature; Body Weight; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan; Tiopronin	1988
Influence of enkephalinase inhibitors on gastric emptying in mice depends on the nature of the meal. Life sciences, 1988, Volume: 42, Issue:21 Topics: Amino Acids, Sulfur; Animals; Dietary Fats; Enkephalin, Methionine; Gastric Emptying; Male; Mice; Thiorphan; Tiopronin	1988
Labelling and exploration of the active site of enkephalinase (EC 3.4.24.11) in kidney membranes with [3H]thiorphan as ligand. European journal of pharmacology, 1988, Apr-27, Volume: 149, Issue:1-2 Topics: Amino Acids, Sulfur; Animals; Binding Sites; Cell Membrane; In Vitro Techniques; Kidney; Ligands; Male; Metalloendopeptidases; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1988
Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Ferrets; Glycopeptides; Kinins; Male; Metalloendopeptidases; Muscle Contraction; Neprilysin; Thiorphan; Tiopronin; Trachea	1988
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors. Neuropharmacology, 1987, Volume: 26, Issue:4 Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time; Sincalide; Tetragastrin; Thiorphan; Tiopronin	1987
Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes. Life sciences, 1987, Jul-13, Volume: 41, Issue:2 Topics: Aminopeptidases; Analgesia; Animals; Corpus Striatum; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Drug Synergism; Endopeptidases; Enkephalin, Methionine; Guinea Pigs; Hydroxamic Acids; Male; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin	1987
Origin of the stimulation of food intake by oral administration of enkephalinase inhibitors in sheep. Life sciences, 1987, Jul-20, Volume: 41, Issue:3 Topics: Administration, Oral; Amino Acids, Sulfur; Analgesics; Animals; Appetite; Cerebral Ventricles; Endopeptidases; Female; Injections, Intravenous; Injections, Intraventricular; Neprilysin; Protease Inhibitors; Sheep; Thiorphan; Tiopronin	1987
Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility). The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1 Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Leucine; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Pimozide; Stress, Physiological; Thiorphan; Tiopronin	1988
Potentiation of phencyclidine-induced stereotyped behaviors in rats by thiorphan and bestatin. European journal of pharmacology, 1986, Jan-14, Volume: 120, Issue:1 Topics: Amino Acids, Sulfur; Animals; Drug Synergism; Leucine; Male; Naloxone; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Thiorphan; Time Factors; Tiopronin	1986
Investigation on the metabolism of CCK8 analogues by rat brain slices. Neuropeptides, 1986, Volume: 7, Issue:1 Topics: Animals; Cerebral Cortex; Chloromercuribenzoates; Corpus Striatum; Hydrolysis; In Vitro Techniques; Leucine; p-Chloromercuribenzoic Acid; Peptide Fragments; Sincalide; Swine; Synaptic Membranes; Thiorphan; Tiopronin	1986
Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1 Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Methionine; Leucine; Male; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin	1986
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain. Neuropharmacology, 1986, Volume: 25, Issue:5 Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Time Factors; Tiopronin	1986
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord. Brain research, 1987, Apr-07, Volume: 408, Issue:1-2 Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin	1987
Relationship between the inhibitory potencies of thiorphan and retrothiorphan enantiomers on thermolysin and neutral endopeptidase 24.11 and their interactions with the thermolysin active site by computer modelling. Biochemical and biophysical research communications, 1987, Sep-30, Volume: 147, Issue:3 Topics: Amino Acids, Sulfur; Binding Sites; Computer Simulation; Isomerism; Metalloendopeptidases; Neprilysin; Protease Inhibitors; Protein Conformation; Thermodynamics; Thermolysin; Thiorphan; Tiopronin; Zinc	1987
Enantiomers of thiorphan and acetorphan: correlation between enkephalinase inhibition, protection of endogenous enkephalins and behavioral effects. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2 Topics: Amino Acids, Sulfur; Analgesia; Angiotensin-Converting Enzyme Inhibitors; Animals; Corpus Striatum; Enkephalins; Globus Pallidus; In Vitro Techniques; Male; Metalloendopeptidases; Mice; Motor Activity; Neprilysin; Rats; Rats, Inbred Strains; Stereoisomerism; Thermolysin; Thiorphan; Tiopronin	1987
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors. European journal of pharmacology, 1987, Dec-01, Volume: 144, Issue:2 Topics: Amino Acids, Sulfur; Animals; Castor Oil; Diarrhea; Drug Interactions; Gastrointestinal Transit; Loperamide; Male; Metalloendopeptidases; Mice; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1987
Electroacupuncture and morphine analgesia potentiated by bestatin and thiorphan administered to the nucleus accumbens of the rabbit. Brain research, 1986, Aug-20, Volume: 380, Issue:2 Topics: Amino Acids, Sulfur; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Immune Sera; Leucine; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Rabbits; Septal Nuclei; Thiorphan; Time Factors; Tiopronin; Transcutaneous Electric Nerve Stimulation	1986
1H NMR configurational correlation for retro-inverso dipeptides: application to the determination of the absolute configuration of "enkephalinase" inhibitors. Relationships between stereochemistry and enzyme recognition. Journal of medicinal chemistry, 1986, Volume: 29, Issue:5 Topics: Amino Acids, Sulfur; Chromatography, High Pressure Liquid; Dipeptides; Endopeptidases; Magnetic Resonance Spectroscopy; Methylation; Neprilysin; Protease Inhibitors; Protein Conformation; Stereoisomerism; Thiorphan; Tiopronin	1986
Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:3 Topics: Amino Acids, Sulfur; Analgesics; Animals; Antidiarrheals; Biogenic Amines; Brain Chemistry; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Injections; Kinetics; Male; Mice; Naloxone; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1986
Effects of peptidase inhibitors on the [Met5]-enkephalin hydrolysis in ileal and striatal preparations of guinea-pig: almost complete protection of degradation by the combination of amastatin, captopril and thiorphan. Japanese journal of pharmacology, 1986, Volume: 41, Issue:4 Topics: Animals; Anti-Bacterial Agents; Captopril; Corpus Striatum; Enkephalin, Methionine; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Male; Membranes; Oligopeptides; Peptides; Protease Inhibitors; Thiorphan; Tiopronin	1986
Naloxone-insensitive potentiation of neurotensin hypothermic effect by the enkephalinase inhibitor thiorphan. Brain research, 1986, Nov-29, Volume: 398, Issue:2 Topics: Amino Acids, Sulfur; Animals; Body Temperature; Captopril; Drug Synergism; Endopeptidases; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Neprilysin; Neurotensin; Thiorphan; Tiopronin	1986
Characterisation of two probes for the localisation of enkephalinase in rat brain: [3H]thiorphan and a 125I-labeled monoclonal antibody. European journal of pharmacology, 1987, Jan-13, Volume: 133, Issue:2 Topics: Amino Acids, Sulfur; Animals; Antibodies, Monoclonal; Autoradiography; Binding Sites; Brain; Endopeptidases; Iodine Radioisotopes; Kinetics; Male; Neprilysin; Radioligand Assay; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin; Tritium	1987
Inhibition of enkephalinase activity attenuates naloxone-precipitated withdrawal symptoms. General pharmacology, 1987, Volume: 18, Issue:1 Topics: Amino Acids, Sulfur; Animals; Behavior, Animal; Endopeptidases; Injections; Injections, Intraventricular; Male; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan; Tiopronin	1987
An inhibitory action of tetracyclines on guinea-pig myenteric plexus. Naunyn-Schmiedeberg's archives of pharmacology, 1987, Volume: 335, Issue:2 Topics: Animals; Captopril; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Leucine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Protease Inhibitors; Tetracyclines; Thiorphan; Tiopronin	1987
In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain. European journal of pharmacology, 1985, Nov-05, Volume: 117, Issue:2 Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Corpus Striatum; Dipeptides; Enkephalin, Methionine; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Mice; Protease Inhibitors; Rats; Thiorphan; Tiopronin	1985
Changes in body temperature and metabolic rate following microinjection of Met-enkephalinamide in the preoptic/anterior hypothalamus of rats. Regulatory peptides, 1985, Nov-28, Volume: 12, Issue:4 Topics: Animals; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; Enkephalin, Methionine; Male; Metabolic Clearance Rate; Microinjections; Naloxone; Preoptic Area; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1985
[Electroacupuncture accelerates the biogenesis of central enkephalins in the rat]. Sheng li xue bao : [Acta physiologica Sinica], 1985, Volume: 37, Issue:3 Topics: Acupuncture Therapy; Aminopeptidases; Animals; Brain; Electric Stimulation Therapy; Enkephalin, Leucine; Enkephalin, Methionine; Female; Leucine; Male; Phenylalanine; Radioimmunoassay; Rats; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation	1985
Enhancement of colonic motor response to feeding by central endogenous opiates in the dog. Life sciences, 1985, Jul-01, Volume: 36, Issue:26 Topics: Animals; Colon; Dogs; Eating; Endorphins; Enkephalin, Methionine; Female; Gastrointestinal Motility; Humans; Mice; Naltrexone; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin	1985
Thiorphan and analogs: lack of correlation between potency to inhibit "enkephalinase A" in vitro and analgesic potency in vivo. The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:2 Topics: Amino Acids, Sulfur; Analgesics; Animals; Enkephalins; In Vitro Techniques; Male; Mice; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Stereoisomerism; Thiorphan; Tiopronin	1985
New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties. Journal of medicinal chemistry, 1985, Volume: 28, Issue:9 Topics: Aminopeptidases; Analgesia; Animals; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Hydroxylamines; Leucine; Male; Mice; Neprilysin; Protease Inhibitors; Rabbits; Rats; Stereoisomerism; Thiorphan; Tiopronin	1985
[Enkephalinase, an enzyme in the catabolism of neuropeptides and circulating hormones]. Revue medicale de Bruxelles, 1985, Volume: 6, Issue:6 Topics: Brain; Endopeptidases; Enkephalins; Humans; Kidney; Neprilysin; Nerve Tissue Proteins; Thiorphan; Tiopronin	1985
Binding of the bidentate inhibitor [3H]HACBO-Gly to the rat brain neutral endopeptidase "enkephalinase". Biochemical and biophysical research communications, 1985, Aug-30, Volume: 131, Issue:1 Topics: Animals; Brain; Captopril; Cell Membrane; Corpus Striatum; Glycine; Hydroxylamines; Leucine; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Substantia Nigra; Thiorphan; Tiopronin; Tissue Distribution	1985
Relationship between enkephalinase inhibition of thiorphan in vivo and its analgesic activity. Journal of pharmacobio-dynamics, 1985, Volume: 8, Issue:9 Topics: Amino Acids, Sulfur; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Brain; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Morphine; Neprilysin; Nerve Tissue Proteins; Nociceptors; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time; Thiorphan; Tiopronin	1985
Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors. European journal of pharmacology, 1985, Dec-17, Volume: 119, Issue:3 Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Mice; Microwaves; Nalorphine; Neprilysin; Oligopeptides; Protease Inhibitors; Radioimmunoassay; Thiorphan; Tiopronin	1985
[Inhibition of enkephalins degradation in the nucleus accumbens leads to potentiation of acupuncture and morphine analgesia]. Sheng li xue bao : [Acta physiologica Sinica], 1985, Volume: 37, Issue:4 Topics: Acupuncture Therapy; Aminopeptidases; Analgesia; Animals; Electric Stimulation Therapy; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Morphine; Neprilysin; Nucleus Accumbens; Protease Inhibitors; Rabbits; Septal Nuclei; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation	1985
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia. European journal of pharmacology, 1984, May-18, Volume: 101, Issue:1-2 Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan; Tiopronin	1984
The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileum. Japanese journal of pharmacology, 1984, Volume: 36, Issue:1 Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Neprilysin; Oligopeptides; Peptides; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin	1984
Physical dependence produced by chronic intracerebroventricular infusion of [D-Arg]kyotorphin or thiorphan to rats. European journal of pharmacology, 1984, Oct-15, Volume: 105, Issue:3-4 Topics: Amino Acids, Sulfur; Analgesics; Animals; Cerebral Ventricles; Endorphins; Humans; Male; Morphine; Naloxone; Neprilysin; Opioid-Related Disorders; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome; Thiorphan; Tiopronin	1984
Action of peptidase inhibitors on methionine5-enkephalin-arginine6-phenylalanine7 (YGGFMRF) and methionine5-enkephalin (YGGFM) metabolism and on electroacupuncture antinociception. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:2 Topics: Acupuncture Therapy; Analgesia; Animals; Captopril; Electronarcosis; Enkephalin, Methionine; Leucine; Male; Perfusion; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Thiorphan; Tiopronin	1984
Degradation of exogenous enkephalin in the guinea-pig ileum: relative importance of aminopeptidase, enkephalinase and angiotensin converting enzyme activity. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:1 Topics: Aminopeptidases; Angiotensin I; Animals; Bradykinin; Endopeptidases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin	1982
Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan. Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:11 Topics: Amino Acids, Sulfur; Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Corpus Striatum; Kinetics; Mice; Protease Inhibitors; Stereoisomerism; Structure-Activity Relationship; Thiorphan; Tiopronin	1983
Degradation of neurotensin by rat brain synaptic membranes: involvement of a thermolysin-like metalloendopeptidase (enkephalinase), angiotensin-converting enzyme, and other unidentified peptidases. Journal of neurochemistry, 1983, Volume: 41, Issue:2 Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Endopeptidases; Kinetics; Male; Neprilysin; Neurotensin; Peptide Hydrolases; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Rats, Inbred Strains; Synaptic Membranes; Thiorphan; Tiopronin	1983
Pain control by endogenous enkephalins is mediated by mu opioid receptors. Life sciences, 1983, Volume: 33 Suppl 1 Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin	1983
Enkephalin degradation by enkephalinergic neuroblastoma cells. Involvement of angiotensin-converting-enzyme. Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 325, Issue:3 Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Cell Membrane; Cells, Cultured; Enkephalin, Leucine; Hydrolysis; Leucine; Mice; Neuroblastoma; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin	1984
Opioid activity of enkephalin analogues containing the kyotorphin-related structure in the N-terminus. Neuropharmacology, 1984, Volume: 23, Issue:4 Topics: Analgesics; Animals; Brain; Cell Membrane; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Thiorphan; Tiopronin; Vas Deferens	1984
Localization of the thiorphan-sensitive endopeptidase, termed enkephalinase A, on glial cells. FEBS letters, 1983, Mar-07, Volume: 153, Issue:1 Topics: Aminopeptidases; Animals; Astrocytes; Brain; Cell Membrane; Cells, Cultured; Endopeptidases; Enkephalin, Leucine; Kinetics; Leucine; Neprilysin; Protease Inhibitors; Rats; Thiorphan; Tiopronin	1983
Peptidases involved in the inactivation of exogenous and endogenous enkephalins. Journal of neural transmission. Supplementum, 1983, Volume: 18 Topics: Aminopeptidases; Animals; Brain; Endopeptidases; Enkephalins; Leucine; Mice; Neprilysin; Nociceptors; Rats; Thiorphan; Tiopronin	1983
Enkephalinase 'A' inhibition by thiorphan: central and peripheral cardiovascular effects. European journal of pharmacology, 1983, Oct-14, Volume: 94, Issue:1-2 Topics: Amino Acids, Sulfur; Anesthesia; Animals; Hemodynamics; Injections, Intraventricular; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin	1983
Depressive effects of morphine and of an enkephalinase inhibitor on responses of ventro-basal thalamic neurones to noxious stimuli. Life sciences, 1983, Volume: 33 Suppl 1 Topics: Amino Acids, Sulfur; Animals; Morphine; Neprilysin; Neurons; Nociceptors; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Thalamus; Thiorphan; Tiopronin	1983
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats. Neuropharmacology, 1983, Volume: 22, Issue:11 Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Sensory Thresholds; Species Specificity; Thiorphan; Tiopronin	1983
Potentiation of the hypoglycemic effect of insulin by thiorphan, an enkephalinase inhibitor. European journal of pharmacology, 1984, Jun-15, Volume: 102, Issue:1 Topics: Amino Acids, Sulfur; Animals; Blood Glucose; Brain; Drug Synergism; Enkephalin, Methionine; Insulin; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1984
Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes. European journal of pharmacology, 1984, Jul-20, Volume: 102, Issue:3-4 Topics: Aminopeptidases; Analgesics; Animals; Brain; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kidney; Leucine; Neprilysin; Protease Inhibitors; Rabbits; Rats; Reaction Time; Thiorphan; Tiopronin	1984
Inactivation of neurotensin by rat brain synaptic membranes. Cleavage at the Pro10-Tyr11 bond by endopeptidase 24.11 (enkephalinase) and a peptidase different from proline-endopeptidase. Journal of neurochemistry, 1984, Volume: 43, Issue:5 Topics: Animals; Captopril; Dipeptides; Endopeptidases; Hydrolysis; Leucine; Neprilysin; Neurotensin; Peptide Fragments; Peptide Hydrolases; Proline; Prolyl Oligopeptidases; Rats; Serine Endopeptidases; Synaptic Membranes; Thiorphan; Tiopronin; Tyrosine	1984
Effect of bestatin and thiorphan on [Met5]enkephalin-Arg6-Phe7-induced analgesia. European journal of pharmacology, 1984, Oct-15, Volume: 105, Issue:3-4 Topics: Amino Acids, Sulfur; Aminopeptidases; Analgesia; Animals; Enkephalin, Methionine; Leucine; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1984
Biochemical and immunological properties of a membrane-bound brain metalloendopeptidase: comparison with thermolysin-like kidney neutral metalloendopeptidase. Journal of neurochemistry, 1984, Volume: 42, Issue:1 Topics: Animals; Brain; Endopeptidases; Hydrogen-Ion Concentration; Hydrolysis; Immunodiffusion; Kidney; Metalloendopeptidases; Oligopeptides; Rabbits; Thermolysin; Thiorphan; Tiopronin	1984
[Inhibition of the evoked liberation of (Met5)enkephalin from slices of globus pallidus in the presence of thiorphan and bestatin]. Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 1983, Volume: 297, Issue:13 Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Electric Stimulation; Enkephalin, Methionine; Globus Pallidus; In Vitro Techniques; Leucine; Potassium Chloride; Protease Inhibitors; Rats; Thiorphan; Tiopronin	1983
Inhibition of enkephalin metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor. European journal of pharmacology, 1983, Jan-21, Volume: 86, Issue:3-4 Topics: Aminopeptidases; Analgesics; Animals; Brain; Drug Synergism; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Puromycin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1983
The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats. Brain research, 1983, May-09, Volume: 267, Issue:1 Topics: Amino Acids, Sulfur; Analgesia; Animals; Arthritis; Arthritis, Experimental; Male; Morphine; Naloxone; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Sensory Thresholds; Thiorphan; Tiopronin; Vocalization, Animal	1983
Purification and characterization of enkephalin-degradating enzymes from calf-brain striatum. Biochemical and biophysical research communications, 1983, Sep-15, Volume: 115, Issue:2 Topics: Aminopeptidases; Animals; Cattle; Corpus Striatum; Dipeptides; Enkephalin, Leucine; Kinetics; Thiorphan; Tiopronin; Tissue Distribution	1983
Involvement of endogenous enkephalins in the mouse 'behavioral despair' test. European journal of pharmacology, 1984, Jan-27, Volume: 97, Issue:3-4 Topics: Aminopeptidases; Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Motor Activity; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin	1984
Endogenous opiate reward induced by an enkephalinase inhibitor, thiorphan, injected into the ventral midbrain. Behavioral neuroscience, 1984, Volume: 98, Issue:2 Topics: Amino Acids, Sulfur; Animals; Endorphins; Enkephalin, Methionine; Female; Mesencephalon; Naloxone; Rats; Rats, Inbred Strains; Reward; Tegmentum Mesencephali; Thiorphan; Tiopronin	1984
The inhibitory effect of opioid peptides and morphine applied intrathecally and intracerebroventricularly on the micturition reflex in the cat. Brain research, 1984, Apr-23, Volume: 298, Issue:1 Topics: Animals; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Female; Morphine; Naloxone; Oligopeptides; Reflex; Thiorphan; Tiopronin; Urination	1984
Comparisons between warm and cold water swim stress in mice. Life sciences, 1984, Aug-06, Volume: 35, Issue:6 Topics: Analgesia; Animals; Cold Temperature; Hot Temperature; Male; Mice; Naloxone; Protease Inhibitors; Stress, Physiological; Swimming; Thiorphan; Time Factors; Tiopronin	1984
Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin. European journal of pharmacology, 1984, Sep-17, Volume: 104, Issue:3-4 Topics: alpha-Methyltyrosine; Amino Acids, Sulfur; Aminopeptidases; Animals; Biogenic Amines; Brain; Enkephalins; Leucine; Male; Methyltyrosines; Mice; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin	1984
Nociception, enkephalin content and dipeptidyl carboxypeptidase activity in brain of mice treated with exopeptidase inhibitors. Neuropharmacology, 1982, Volume: 21, Issue:7 Topics: Animals; Brain; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Enkephalins; Exopeptidases; Female; Leucine; Mice; Neprilysin; Nociceptors; Protease Inhibitors; Thiorphan; Tiopronin	1982
In vitro and in vivo effects of thiorphan: an inhibitor of enkephalinase A. Advances in biochemical psychopharmacology, 1982, Volume: 33 Topics: Amino Acids, Sulfur; Aminopeptidases; Analgesics; Animals; Captopril; Drug Synergism; Enkephalins; In Vitro Techniques; Male; Mice; Naloxone; Neprilysin; Protease Inhibitors; Thiorphan; Tiopronin	1982
Possible role of dipeptidyl carboxypeptidase n the metabolism of Met5-enkephalin and Met5-enkephalin-Arg6-Phe7. Advances in biochemical psychopharmacology, 1982, Volume: 33 Topics: Animals; Captopril; Cattle; Chlorides; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1982
Phasic enkephalinergic modulation of nigrostriatal dopamine metabolism: potentiation with enkephalinase inhibitors. European journal of pharmacology, 1982, Aug-13, Volume: 82, Issue:1-2 Topics: Animals; Corpus Striatum; Dopamine; Enkephalins; Hydroxamic Acids; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Substantia Nigra; Thiorphan; Tiopronin	1982
Potentiation of [D-ala2]enkephalinamide analgesia in rats by thiorphan. European journal of pharmacology, 1982, Sep-24, Volume: 83, Issue:3-4 Topics: Amino Acids, Sulfur; Analgesics; Animals; Drug Synergism; Enkephalin, Methionine; Male; Naloxone; Neprilysin; Nociceptors; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Time Factors; Tiopronin	1982
The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice. Nature, 1980, Nov-20, Volume: 288, Issue:5788 Topics: Amino Acids, Sulfur; Analgesia; Animals; Binding Sites; Dose-Response Relationship, Drug; Drug Synergism; Endorphins; Enkephalins; Mice; Neprilysin; Nociceptors; Protease Inhibitors; Thiorphan; Tiopronin	1980
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition. Science (New York, N.Y.), 1981, Jun-05, Volume: 212, Issue:4499 Topics: Amino Acids, Sulfur; Animals; Corpus Striatum; Endorphins; Enkephalin, Methionine; Enkephalins; Mice; Neprilysin; Potassium; Protease Inhibitors; Rats; Thiorphan; Tiopronin	1981
Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5] enkephalin. European journal of pharmacology, 1982, Apr-23, Volume: 79, Issue:3-4 Topics: Amino Acids, Sulfur; Analgesics; Animals; Captopril; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Injections, Spinal; Macaca; Morphine; Neprilysin; Protease Inhibitors; Rats; Species Specificity; Thiorphan; Tiopronin	1982
Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors. The Biochemical journal, 1982, May-01, Volume: 203, Issue:2 Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalins; Glycopeptides; Hydrolysis; Kidney; Neprilysin; Organophosphorus Compounds; Protease Inhibitors; Swine; Synaptic Membranes; Thermolysin; Thiorphan; Tiopronin	1982
Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase (PAM). FEBS letters, 2006, Jan-23, Volume: 580, Issue:2 Topics: Animals; Binding Sites; Copper; Mixed Function Oxygenases; Molecular Structure; Multienzyme Complexes; Oxidation-Reduction; Protease Inhibitors; Protein Structure, Tertiary; Rats; Thiorphan; Tiopronin	2006