Page last updated: 2024-08-16

tiopronin and leucine

tiopronin has been researched along with leucine in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	41 (95.35)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (4.65)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Benoliel, JJ; Berthier, JL; Bourgoin, S; Cesselin, F; Hamon, M; Hirsch, M; Mauborgne, A	1
Livett, BG; Marley, PD; Mitchelhill, KI	1
Aoki, K; Kajiwara, M; Oka, T	2
Basilico, L; Giagnoni, G; Gori, E; Mennuni, L; Parolaro, D; Pecora, N	1
Giros, B; Gros, C; Llorens-Cortes, C; Schwartz, JC	1
Borson, DB; Jacoby, DB; Nadel, JA; Tamaoki, J	1
Martinez, JL; Walker, RC; Weinberger, SB; Zafuto, CE	1
Gros, C; Llorens-Cortes, C; Schwartz, JC	2
Bourgoin, S; Cesselin, F; Dickenson, AH; Fournié-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP	1
Hill, RG; Hughes, J; Pittaway, KM	1
Kameyama, T; Katoh, A; Nabeshima, T	1
Fukaya, H; Furukawa, H; Hiramatsu, M; Kameyama, T; Nabeshima, T	1
Charpentier, B; Durieux, C; Pelaprat, D; Roques, BP	1
Artaud, F; Bouboutou, R; Bourgoin, S; Cesselin, F; Clot, AM; Fournie-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP	1
Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H	1
Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF	1
Han, JS; Jin, WQ; Zhou, ZF	2
Coquerel, A; Costentin, J; Dubuc, I; Kitabgi, P; Menard, JF	1
Anadón, A; Martinez-Larrañaga, MR	1
Bouboutou, R; Bourgoin, S; Cesselin, F; Devin, J; Fournie-Zaluski, MC; Hamon, M; Roques, B; Waksman, G	1
Han, JS; Yuan, H	1
Bouboutou, R; Chaillet, P; Costentin, J; Coulaud, A; Devin, J; Fournié-Zaluski, MC; Roques, BP; Waksman, G	1
Besselievre, R; Bouboutou, R; Devin, J; Fournie-Zaluski, MC; Roques, BP; Waksman, G	1
Chaillet, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Zajac, JM	1
Chou, J; Costa, E; Del Rio, J; Tang, J; Yang, HY	1
Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP	1
Brandt, U; Lentzen, H; Palenker, J	1
Lentzen, H; Palenker, J	1
Chaillet, P; Costentin, J; de la Baume, S; Marcais-Collado, H; Schwartz, JC; Yi, CC	2
Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A	2
Bouboutou, R; Chaillet, P; Cherot, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Waksman, G	1
Checler, F; Emson, PC; Kitabgi, P; Vincent, JP	1
de la Baume, S; Giros, B; Gros, C; Schwartz, JC	1
Chaillet, P; Costentin, J; Lecomte, JM; Marçais, H; Natan, LB; Uchida, G	1
Llorens-Cortes, C; Schwartz, JC	1
Costa, E; Yang, HY; Zhang, AZ	1
Bond, JS; Hengst, JA	1

Other Studies

43 other study(ies) available for tiopronin and leucine

Article	Year
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2 Topics: Animals; Captopril; Dipeptides; In Vitro Techniques; Leucine; Male; Metalloendopeptidases; Naloxone; Neprilysin; Oligopeptides; Peptidyl-Dipeptidase A; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Thiorphan; Tiopronin	1987
Effects of opioid peptides containing the sequence of Met5-enkephalin or Leu5-enkephalin on nicotine-induced secretion from bovine adrenal chromaffin cells. Journal of neurochemistry, 1986, Volume: 46, Issue:1 Topics: Adenosine Triphosphate; Adrenal Medulla; Amino Acid Sequence; Animals; Bacitracin; Cattle; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Epinephrine; Guinea Pigs; Leucine; Nicotine; Norepinephrine; Peptide Fragments; Phenanthrolines; Rabbits; Receptors, Opioid; Thiorphan; Tiopronin	1986
The inactivation of [Met5]-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens. Japanese journal of pharmacology, 1986, Volume: 40, Issue:2 Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Captopril; Dipeptides; Dose-Response Relationship, Drug; Endopeptidases; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Neprilysin; Peptidyl-Dipeptidase A; Phenylalanine; Thiorphan; Tiopronin; Vas Deferens	1986
Binding studies of dermorphin and its L-form on rat brain opioid receptors. Pharmacological research communications, 1987, Volume: 19, Issue:2 Topics: Alanine; Animals; Binding, Competitive; Biological Assay; Brain; Captopril; Ileum; Leucine; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship; Thiorphan; Tiopronin	1987
[Opioid peptides: metabolism and receptors]. Gastroenterologie clinique et biologique, 1987, Volume: 11, Issue:3 Pt 2 Topics: Animals; Brain; Cattle; Endopeptidases; Endorphins; Enkephalins; Humans; Leucine; Mice; Neprilysin; Pro-Opiomelanocortin; Protease Inhibitors; Protein Precursors; Receptors, Opioid; Thiorphan; Tiopronin	1987
Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase. Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 64, Issue:6 Topics: Animals; Captopril; Disease Models, Animal; Ferrets; In Vitro Techniques; Influenza A virus; Leucine; Leupeptins; Metalloendopeptidases; Muscle Contraction; Muscle, Smooth; Neprilysin; Orthomyxoviridae Infections; Thiorphan; Tiopronin; Trachea	1988
Characterization of enkephalin degradation in rat plasma. NIDA research monograph, 1986, Volume: 75 Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Leucine; Enkephalins; Kinetics; Leucine; Male; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1986
Evaluation of striatal enkephalin release in vivo from steady state levels and turnover rates of the tripeptide Tyr-Gly-Gly. NIDA research monograph, 1986, Volume: 75 Topics: Animals; Anti-Bacterial Agents; Corpus Striatum; Enkephalins; In Vitro Techniques; Kinetics; Leucine; Male; Mice; Oligopeptides; Pentobarbital; Thiorphan; Tiopronin	1986
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord. NIDA research monograph, 1986, Volume: 75 Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain; Rats; Spinal Cord; Thiorphan; Tiopronin	1986
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors. Neuropharmacology, 1987, Volume: 26, Issue:4 Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time; Sincalide; Tetragastrin; Thiorphan; Tiopronin	1987
Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility). The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:1 Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Corpus Striatum; Dopamine; Enkephalin, Methionine; Enkephalins; Leucine; Male; Metalloendopeptidases; Mice; Motor Activity; Naloxone; Neprilysin; Pimozide; Stress, Physiological; Thiorphan; Tiopronin	1988
Potentiation of phencyclidine-induced stereotyped behaviors in rats by thiorphan and bestatin. European journal of pharmacology, 1986, Jan-14, Volume: 120, Issue:1 Topics: Amino Acids, Sulfur; Animals; Drug Synergism; Leucine; Male; Naloxone; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Thiorphan; Time Factors; Tiopronin	1986
Investigation on the metabolism of CCK8 analogues by rat brain slices. Neuropeptides, 1986, Volume: 7, Issue:1 Topics: Animals; Cerebral Cortex; Chloromercuribenzoates; Corpus Striatum; Hydrolysis; In Vitro Techniques; Leucine; p-Chloromercuribenzoic Acid; Peptide Fragments; Sincalide; Swine; Synaptic Membranes; Thiorphan; Tiopronin	1986
Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1 Topics: Animals; Dipeptides; Dose-Response Relationship, Drug; Enkephalin, Methionine; Leucine; Male; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin	1986
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain. Neuropharmacology, 1986, Volume: 25, Issue:5 Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Time Factors; Tiopronin	1986
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord. Brain research, 1987, Apr-07, Volume: 408, Issue:1-2 Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin	1987
Electroacupuncture and morphine analgesia potentiated by bestatin and thiorphan administered to the nucleus accumbens of the rabbit. Brain research, 1986, Aug-20, Volume: 380, Issue:2 Topics: Amino Acids, Sulfur; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Methionine; Immune Sera; Leucine; Male; Microinjections; Morphine; Naloxone; Nucleus Accumbens; Rabbits; Septal Nuclei; Thiorphan; Time Factors; Tiopronin; Transcutaneous Electric Nerve Stimulation	1986
Naloxone-insensitive potentiation of neurotensin hypothermic effect by the enkephalinase inhibitor thiorphan. Brain research, 1986, Nov-29, Volume: 398, Issue:2 Topics: Amino Acids, Sulfur; Animals; Body Temperature; Captopril; Drug Synergism; Endopeptidases; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Neprilysin; Neurotensin; Thiorphan; Tiopronin	1986
An inhibitory action of tetracyclines on guinea-pig myenteric plexus. Naunyn-Schmiedeberg's archives of pharmacology, 1987, Volume: 335, Issue:2 Topics: Animals; Captopril; Drug Interactions; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Leucine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Protease Inhibitors; Tetracyclines; Thiorphan; Tiopronin	1987
In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain. European journal of pharmacology, 1985, Nov-05, Volume: 117, Issue:2 Topics: Aminopeptidases; Animals; Brain; Brain Chemistry; Corpus Striatum; Dipeptides; Enkephalin, Methionine; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Mice; Protease Inhibitors; Rats; Thiorphan; Tiopronin	1985
[Electroacupuncture accelerates the biogenesis of central enkephalins in the rat]. Sheng li xue bao : [Acta physiologica Sinica], 1985, Volume: 37, Issue:3 Topics: Acupuncture Therapy; Aminopeptidases; Animals; Brain; Electric Stimulation Therapy; Enkephalin, Leucine; Enkephalin, Methionine; Female; Leucine; Male; Phenylalanine; Radioimmunoassay; Rats; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation	1985
New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties. Journal of medicinal chemistry, 1985, Volume: 28, Issue:9 Topics: Aminopeptidases; Analgesia; Animals; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Hydroxylamines; Leucine; Male; Mice; Neprilysin; Protease Inhibitors; Rabbits; Rats; Stereoisomerism; Thiorphan; Tiopronin	1985
Binding of the bidentate inhibitor [3H]HACBO-Gly to the rat brain neutral endopeptidase "enkephalinase". Biochemical and biophysical research communications, 1985, Aug-30, Volume: 131, Issue:1 Topics: Animals; Brain; Captopril; Cell Membrane; Corpus Striatum; Glycine; Hydroxylamines; Leucine; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Substantia Nigra; Thiorphan; Tiopronin; Tissue Distribution	1985
Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: validation of a radioimmunoassay, localisation and effects of peptidase inhibitors. European journal of pharmacology, 1985, Dec-17, Volume: 119, Issue:3 Topics: Animals; Brain; Captopril; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Mice; Microwaves; Nalorphine; Neprilysin; Oligopeptides; Protease Inhibitors; Radioimmunoassay; Thiorphan; Tiopronin	1985
[Inhibition of enkephalins degradation in the nucleus accumbens leads to potentiation of acupuncture and morphine analgesia]. Sheng li xue bao : [Acta physiologica Sinica], 1985, Volume: 37, Issue:4 Topics: Acupuncture Therapy; Aminopeptidases; Analgesia; Animals; Electric Stimulation Therapy; Endopeptidases; Enkephalin, Leucine; Enkephalin, Methionine; Leucine; Male; Morphine; Neprilysin; Nucleus Accumbens; Protease Inhibitors; Rabbits; Septal Nuclei; Thiorphan; Tiopronin; Transcutaneous Electric Nerve Stimulation	1985
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia. European journal of pharmacology, 1984, May-18, Volume: 101, Issue:1-2 Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan; Tiopronin	1984
The role of bestatin-sensitive aminopeptidase, angiotensin converting enzyme and thiorphan-sensitive "enkephalinase" in the potency of enkephalins in the guinea-pig ileum. Japanese journal of pharmacology, 1984, Volume: 36, Issue:1 Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Anti-Bacterial Agents; Captopril; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Leucine; Male; Neprilysin; Oligopeptides; Peptides; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin	1984
Action of peptidase inhibitors on methionine5-enkephalin-arginine6-phenylalanine7 (YGGFMRF) and methionine5-enkephalin (YGGFM) metabolism and on electroacupuncture antinociception. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:2 Topics: Acupuncture Therapy; Analgesia; Animals; Captopril; Electronarcosis; Enkephalin, Methionine; Leucine; Male; Perfusion; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Thiorphan; Tiopronin	1984
Pain control by endogenous enkephalins is mediated by mu opioid receptors. Life sciences, 1983, Volume: 33 Suppl 1 Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin	1983
Enkephalin degradation by enkephalinergic neuroblastoma cells. Involvement of angiotensin-converting-enzyme. Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 325, Issue:3 Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Cell Membrane; Cells, Cultured; Enkephalin, Leucine; Hydrolysis; Leucine; Mice; Neuroblastoma; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin	1984
Localization of the thiorphan-sensitive endopeptidase, termed enkephalinase A, on glial cells. FEBS letters, 1983, Mar-07, Volume: 153, Issue:1 Topics: Aminopeptidases; Animals; Astrocytes; Brain; Cell Membrane; Cells, Cultured; Endopeptidases; Enkephalin, Leucine; Kinetics; Leucine; Neprilysin; Protease Inhibitors; Rats; Thiorphan; Tiopronin	1983
Peptidases involved in the inactivation of exogenous and endogenous enkephalins. Journal of neural transmission. Supplementum, 1983, Volume: 18 Topics: Aminopeptidases; Animals; Brain; Endopeptidases; Enkephalins; Leucine; Mice; Neprilysin; Nociceptors; Rats; Thiorphan; Tiopronin	1983
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats. Neuropharmacology, 1983, Volume: 22, Issue:11 Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Sensory Thresholds; Species Specificity; Thiorphan; Tiopronin	1983
Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes. European journal of pharmacology, 1984, Jul-20, Volume: 102, Issue:3-4 Topics: Aminopeptidases; Analgesics; Animals; Brain; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kidney; Leucine; Neprilysin; Protease Inhibitors; Rabbits; Rats; Reaction Time; Thiorphan; Tiopronin	1984
Inactivation of neurotensin by rat brain synaptic membranes. Cleavage at the Pro10-Tyr11 bond by endopeptidase 24.11 (enkephalinase) and a peptidase different from proline-endopeptidase. Journal of neurochemistry, 1984, Volume: 43, Issue:5 Topics: Animals; Captopril; Dipeptides; Endopeptidases; Hydrolysis; Leucine; Neprilysin; Neurotensin; Peptide Fragments; Peptide Hydrolases; Proline; Prolyl Oligopeptidases; Rats; Serine Endopeptidases; Synaptic Membranes; Thiorphan; Tiopronin; Tyrosine	1984
Effect of bestatin and thiorphan on [Met5]enkephalin-Arg6-Phe7-induced analgesia. European journal of pharmacology, 1984, Oct-15, Volume: 105, Issue:3-4 Topics: Amino Acids, Sulfur; Aminopeptidases; Analgesia; Animals; Enkephalin, Methionine; Leucine; Male; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1984
[Inhibition of the evoked liberation of (Met5)enkephalin from slices of globus pallidus in the presence of thiorphan and bestatin]. Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 1983, Volume: 297, Issue:13 Topics: Amino Acids, Sulfur; Aminopeptidases; Animals; Electric Stimulation; Enkephalin, Methionine; Globus Pallidus; In Vitro Techniques; Leucine; Potassium Chloride; Protease Inhibitors; Rats; Thiorphan; Tiopronin	1983
Inhibition of enkephalin metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor. European journal of pharmacology, 1983, Jan-21, Volume: 86, Issue:3-4 Topics: Aminopeptidases; Analgesics; Animals; Brain; Drug Synergism; Enkephalins; Hydrolysis; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred Strains; Puromycin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1983
Involvement of endogenous enkephalins in the mouse 'behavioral despair' test. European journal of pharmacology, 1984, Jan-27, Volume: 97, Issue:3-4 Topics: Aminopeptidases; Animals; Behavior, Animal; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Motor Activity; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin	1984
Changes in turnover of cerebral monoamines following inhibition of enkephalin metabolism by thiorphan and bestatin. European journal of pharmacology, 1984, Sep-17, Volume: 104, Issue:3-4 Topics: alpha-Methyltyrosine; Amino Acids, Sulfur; Aminopeptidases; Animals; Biogenic Amines; Brain; Enkephalins; Leucine; Male; Methyltyrosines; Mice; Naloxone; Protease Inhibitors; Thiorphan; Tiopronin	1984
Nociception, enkephalin content and dipeptidyl carboxypeptidase activity in brain of mice treated with exopeptidase inhibitors. Neuropharmacology, 1982, Volume: 21, Issue:7 Topics: Animals; Brain; Corpus Striatum; Endopeptidases; Enkephalin, Methionine; Enkephalins; Exopeptidases; Female; Leucine; Mice; Neprilysin; Nociceptors; Protease Inhibitors; Thiorphan; Tiopronin	1982
Transport of meprin subunits through the secretory pathway: role of the transmembrane and cytoplasmic domains and oligomerization. The Journal of biological chemistry, 2004, Aug-13, Volume: 279, Issue:33 Topics: Alanine; Amino Acid Motifs; Amino Acid Sequence; Animals; Caseins; Cell Line; Cell Membrane; Chromatography; Culture Media; Cytoplasm; Dimerization; Disulfides; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Gene Deletion; Glycine; Glycoside Hydrolases; Golgi Apparatus; Humans; Immunoblotting; Leucine; Metalloendopeptidases; Mice; Models, Biological; Molecular Sequence Data; Mutagenesis; Mutation; Plasmids; Protein Structure, Tertiary; Protein Transport; Recombinant Fusion Proteins; Tiopronin	2004