Page last updated: 2024-08-16

timolol and metoprolol

timolol has been researched along with metoprolol in 124 studies

Research

Studies (124)

TimeframeStudies, this research(%)All Research%
pre-199077 (62.10)18.7374
1990's9 (7.26)18.2507
2000's28 (22.58)29.6817
2010's9 (7.26)24.3611
2020's1 (0.81)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Baldwin, JJ; Christy, ME; Denny, GH; Freedman, MB; Gross, DM; Habecker, CN; Lyle, PA; Ponticello, GS; Sweet, CS; Varga, SL1
Carrupt, PA; el Tayar, N; Testa, B; Van de Waterbeemd, H1
Baldwin, JJ; Gross, DM; McClure, DE; Williams, M1
Baldwin, JJ; Denny, GH; Freedman, MB; Gross, DM; Hirschmann, R; Ponticello, GS; Sweet, CS1
Carrupt, PA; Gaillard, P; Schambel, P; Testa, B1
Topliss, JG; Yoshida, F1
Faller, B; Wohnsland, F1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL1
Hwang, KK; Mandagere, AK; Thompson, TN1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Baker, JG1
Caron, G; Ermondi, G1
Chandrasena, G; Gavai, AV; Nayeem, A; Santone, K; Vaz, RJ1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Duke, BJ; Jackman, GP; Louis, SN; Louis, WJ; Machida, CA; Nero, TL; Rezmann-Vitti, LA1
Abraham, MH; Acree, WE; Ibrahim, A1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Bard, B; Carrupt, PA; Martel, S1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chang, Q; Chen, Z; Hu, G; Hu, L; Li, Q; Long, J1
Meier, J1
Lund-Johansen, P2
Kiechel, JR; Meier, J1
Bellucci, R; Bonomi, L; Massa, F; Noya, E; Perfetti, S1
Anderton, RC; Frith, PA; Hargreave, FE; Kumana, CR; Newhouse, MT; Ruffin, RE1
Eliasson, K; Lins, LE; Sundqvist, K1
Lederballe Pedersen, O; Mikkelsen, E1
Bousser, MG; Massiou, H1
Dumasia, MC; Houghton, E1
Akritopoulos, P; Petounis, AD1
From, RP; Mehta, MP; Pathak, D1
Dolva, LO; Eide, I; Gullestad, L; Kjekshus, J; Kjeldsen, SE1
Chiou, GC; Liu, HK; McLaughlin, MA; Watanabe, K1
Palkama, A; Raij, K; Uusitalo, H; Uusitalo, R1
Fletcher, GF1
Lennard, MS1
Smith, RL1
Fishbein, L; Jackson, CD1
Halawa, B; Mazurek, W1
Lennard, MS; Silas, JH; Tucker, GT; Woods, HF1
Tfelt-Hansen, P1
Lathers, CM; Spivey, WH1
Srivastava, KC1
Nathanson, JA1
Eldrup, E; Jørgensen, EO; Knudsen, JB; Winther, K1
Kato, T; Nagamine, F; Nakasone, J; Noguchi, K; Sakanashi, M1
Dolva, LO; Gullestad, L; Kjekshus, J; Søyland, E1
al-Gohary, O; Lyal, J; Murray, JB1
Vidt, DG1
Potter, DE; Rowland, JM1
Johansson, SR; McCall, M; Vedin, JA; Wilhelmsson, C1
Innemee, HC; Ros, FE; van Zwieten, PA1
Lowenthal, DT1
Aeschlimann, J; Bucheli, J; Eltz, H; Gloor, B; Urner-Bloch, U1
Frishman, WH; Koch-Weser, J1
Borer, JS; Moses, JW1
Hjalmarson, A1
Gorlin, R; Moser, M1
Iskandrian, AS; Kotler, MN; Segal, BL1
Moss, AJ1
Alvan, G; Calissendorff, BM; Haglund, K; Marén, N; Seideman, P1
Amery, A; Bulpitt, C; Cattaert, A; Fagard, R; Staessen, J; Vanhees, L1
Julian, DG1
Gettes, LS; Griggs, TR; Wagner, GS1
Vedin, A; Wilhelmsson, C1
Pratt, CM; Roberts, R1
Ribeiro, LG1
Delius, W1
Weisswange, A1
Caimi, G; Capobianco, D; Catania, A; Frazzetta, F; Sarno, A1
Teräväinen, H1
Jackson, EA; Sullman, SA1
Ferguson, RK; Rotmensch, HH; Vlasses, PH1
Chung, DC; Laschuk, MJ1
Friedewald, WT; Frishman, WH; Furberg, CD1
Peele, ME; Shulkin, BL; Utiger, RD1
Tomov, I1
McGoon, MD; Vlietstra, RE1
Buja, LM; Willerson, JT1
Clusin, WT; Gillis, AM1
Khan, AH1
Maroko, PR; Ribeiro, LG; Vik-Mo, H1
Bradley, L; Doggrell, SA1
Gyllenhaal, O; Vessman, J1
Thind, GS1
Eriksen, JS; Nielsen, NV2
Nielsen, NV1
Collignon-Brach, J; Weekers, R1
Alm, A; Törnquist, P; Wickström, CP1
Forfang, K; Gullestad, L1
Osterziel, KJ1
Caldwell, GW; Evangelisto, M; Masucci, JA; White, R1
Caldwell, GW; Demarest, K; Easlick, SM; Gunnet, J; Masucci, JA1
Anderson, GM; Clark, JP; Gurwitz, JH; Lau, P; Rochon, PA; Shear, NH; Tu, JV1
Gordeladze, JO; Jynge, P; Sellevold, OF1
Dale, J; Heldal, M; Sire, S1
Baldridge, WH; Baptiste, DC; Chauhan, BC; Hartwick, AT; Jollimore, CA; Kelly, ME; Tremblay, F1
Abou-Sekkina, MM; El-Ries, MA; Hassan, SS; Wassel, A1
Banga, AK; Betageri, GV; Chaturvedula, A; Conjeevaram, R; Sunkara, G1
Iwaki, M; Kawase, A; Komura, H1
Borer, JS; Camm, AJ; Danchin, N; Ferrari, R; Fox, K; Lopez Sendon, JL; Steg, PG; Tardif, JC; Tavazzi, L; Tendera, M1
Arstall, MA; Beltrame, JF; Horowitz, JD; Zeitz, CJ1
Boralli, VB; Danhof, M; de Lange, EC; Freijer, J; Krekels, EH; Slijkerman, P; van Steeg, TJ1

Reviews

19 review(s) available for timolol and metoprolol

ArticleYear
Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:11

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Models, Molecular; Receptors, Adrenergic, beta; Structure-Activity Relationship

1988
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Comparative pharmacokinetics of beta-blockers].
    La Nouvelle presse medicale, 1978, Sep-20, Volume: 7, Issue:31

    Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Half-Life; Humans; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Sotalol; Timolol

1978
[Beta-blockers and migraine].
    Pathologie-biologie, 1992, Volume: 40, Issue:4

    Topics: Adrenergic beta-Antagonists; Atenolol; Clinical Trials as Topic; Dilatation, Pathologic; Evoked Potentials, Visual; Humans; Metoprolol; Migraine Disorders; Nadolol; Platelet Aggregation; Propranolol; Receptors, Serotonin; Timolol

1992
Oxidation phenotype and the metabolism and action of beta-blockers.
    Klinische Wochenschrift, 1985, Apr-01, Volume: 63, Issue:7

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Drug Interactions; Ethanolamines; Humans; Hypertension; Kinetics; Metoprolol; Oxidation-Reduction; Phenotype; Propranolol; Timolol

1985
A toxicological review of beta-adrenergic blockers.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 6, Issue:3

    Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Cocarcinogenesis; Ethanolamines; Female; Kinetics; Labetalol; Lethal Dose 50; Male; Metoprolol; Mice; Mutagens; Nadolol; Neoplasms, Experimental; Oxprenolol; Pindolol; Practolol; Propanolamines; Propranolol; Rats; Sotalol; Timolol

1986
[Effect of beta-adrenolytic drugs on the survival of patients after myocardial infarction].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1986, Jan-01, Volume: 39, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aftercare; Aged; Clinical Trials as Topic; Follow-Up Studies; Humans; Metoprolol; Middle Aged; Myocardial Infarction; Oxprenolol; Propranolol; Time Factors; Timolol

1986
Advances in the medical management of renovascular hypertension.
    The Urologic clinics of North America, 1984, Volume: 11, Issue:3

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteriosclerosis; Atenolol; Captopril; Dipeptides; Enalapril; Female; Humans; Hypertension, Renovascular; Male; Metoprolol; Middle Aged; Nadolol; Pindolol; Propanolamines; Propranolol; Renal Artery Obstruction; Renin-Angiotensin System; Saralasin; Timolol

1984
beta-Adrenoceptor antagonists: new drugs and new indications.
    The New England journal of medicine, 1981, Aug-27, Volume: 305, Issue:9

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Glaucoma; Humans; Hypertension; Kinetics; Metoprolol; Migraine Disorders; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol

1981
Beta-adrenergic antagonists in the treatment of patients with heart disease.
    Disease-a-month : DM, 1981, Volume: 27, Issue:9

    Topics: Acebutolol; Adrenergic beta-Agonists; Alprenolol; Animals; Arrhythmias, Cardiac; Bronchial Spasm; Cardiomyopathy, Hypertrophic; Coronary Disease; Female; Heart Diseases; Heart Failure; Humans; Hypertension; Metoprolol; Mitral Valve Prolapse; Mitral Valve Stenosis; Nadolol; Nervous System Diseases; Pindolol; Pregnancy; Pregnancy Complications, Cardiovascular; Propanolamines; Propranolol; Receptors, Adrenergic, beta; Structure-Activity Relationship; Timolol

1981
Beta blocking agents: current status in the prevention of sudden coronary death.
    Annals of the New York Academy of Sciences, 1982, Volume: 382

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Atenolol; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Practolol; Propranolol; Prospective Studies; Random Allocation; Timolol

1982
Comparative review of beta-blocking agents.
    Connecticut medicine, 1984, Volume: 48, Issue:4

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Atenolol; Humans; Hypertension; Metoprolol; Migraine Disorders; Myocardial Infarction; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol

1984
The new beta-adrenergic antagonists.
    Canadian Anaesthetists' Society journal, 1984, Volume: 31, Issue:4

    Topics: Adrenergic beta-Antagonists; Atenolol; Humans; Labetalol; Metoprolol; Nadolol; Oxprenolol; Pindolol; Propanolamines; Timolol

1984
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
    Current problems in cardiology, 1984, Volume: 9, Issue:3

    Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans; Hypertension; Metoprolol; Myocardial Infarction; Oxprenolol; Pindolol; Practolol; Propranolol; Receptors, Adrenergic, beta; Risk; Sotalol; Timolol

1984
[Therapeutic value of the long-term administration of beta-adrenergic blockaders after myocardial infarct].
    Vutreshni bolesti, 1984, Volume: 23, Issue:3

    Topics: Adrenergic beta-Antagonists; Alprenolol; Clinical Trials as Topic; Humans; Metoprolol; Myocardial Infarction; Placebos; Practolol; Propranolol; Random Allocation; Sotalol; Time Factors; Timolol

1984
Short- and long-term influence of beta-adrenergic antagonists after acute myocardial infarction.
    The American journal of cardiology, 1984, Dec-21, Volume: 54, Issue:11

    Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Clinical Trials as Topic; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Humans; Metoprolol; Myocardial Infarction; Myocardium; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Time Factors; Timolol

1984
The role of beta-adrenergic receptor antagonists in the prevention of sudden cardiac death.
    Comprehensive therapy, 1984, Volume: 10, Issue:9

    Topics: Action Potentials; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Cardiac Complexes, Premature; Coronary Disease; Drug Therapy, Combination; Humans; Metoprolol; Myocardial Infarction; Propranolol; Recurrence; Time Factors; Timolol

1984
Resting heart rate in cardiovascular disease.
    Journal of the American College of Cardiology, 2007, Aug-28, Volume: 50, Issue:9

    Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Carbazoles; Cardiac Output, Low; Cardiovascular Diseases; Carvedilol; Coronary Artery Disease; Coronary Disease; Exercise Test; Heart Rate; Humans; Metoprolol; Multivariate Analysis; Myocardial Infarction; Myocardial Ischemia; Prognosis; Propanolamines; Risk Assessment; Risk Factors; Timolol; Ventricular Dysfunction, Left

2007
Is there still a role for treatment with beta-adrenoceptor antagonists in post-myocardial infarction patients with well-preserved left ventricular systolic function?
    Acute cardiac care, 2008, Volume: 10, Issue:3

    Topics: Adrenergic Antagonists; Angioplasty, Balloon, Coronary; Endothelium, Vascular; Humans; Metoprolol; Myocardial Infarction; Propranolol; Thrombolytic Therapy; Timolol; Ventricular Function, Left

2008

Trials

29 trial(s) available for timolol and metoprolol

ArticleYear
Selectivity of beta adrenoreceptor antagonist drugs assessed by histamine bronchial provocation.
    Clinical pharmacology and therapeutics, 1979, Volume: 25, Issue:5 Pt 1

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Airway Resistance; Asthma; Double-Blind Method; Drug Interactions; Female; Forced Expiratory Volume; Histamine; Humans; Male; Metoprolol; Middle Aged; Organ Specificity; Propranolol; Pulse; Timolol

1979
[Beta-blockers and migraine].
    Pathologie-biologie, 1992, Volume: 40, Issue:4

    Topics: Adrenergic beta-Antagonists; Atenolol; Clinical Trials as Topic; Dilatation, Pathologic; Evoked Potentials, Visual; Humans; Metoprolol; Migraine Disorders; Nadolol; Platelet Aggregation; Propranolol; Receptors, Serotonin; Timolol

1992
Effect of beta-adrenergic blockade on hormonal responses during continuous and intermittent exercise.
    Cardiovascular drugs and therapy, 1989, Volume: 3, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; Dopamine; Epinephrine; Exercise; Fatigue; Fatty Acids, Nonesterified; Growth Hormone; Heart Rate; Hormones; Humans; Hydrocortisone; Male; Metoprolol; Middle Aged; Norepinephrine; Prolactin; Renin; Timolol

1989
[Effect of beta-adrenolytic drugs on the survival of patients after myocardial infarction].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1986, Jan-01, Volume: 39, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aftercare; Aged; Clinical Trials as Topic; Follow-Up Studies; Humans; Metoprolol; Middle Aged; Myocardial Infarction; Oxprenolol; Propranolol; Time Factors; Timolol

1986
Efficacy of beta-blockers in migraine. A critical review.
    Cephalalgia : an international journal of headache, 1986, Volume: 6 Suppl 5

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Double-Blind Method; Humans; Metoprolol; Migraine Disorders; Nadolol; Propranolol; Racemases and Epimerases; Timolol

1986
Difference between beta-1-selective and non-selective beta-blockade during continuous and intermittent exercise.
    Clinical physiology (Oxford, England), 1988, Volume: 8, Issue:5

    Topics: Administration, Oral; Adult; Blood Pressure; Double-Blind Method; Exercise; Humans; Male; Metoprolol; Middle Aged; Oxygen Consumption; Physical Endurance; Potassium; Random Allocation; Timolol

1988
Duration of action of beta blockers.
    Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Alprenolol; Atenolol; Blood Pressure; Coronary Disease; Heart Rate; Humans; Metoprolol; Penbutolol; Physical Exertion; Pindolol; Propranolol; Regression Analysis; Rest; Sotalol; Time Factors; Timolol

1980
[Clinical trials of various glaucoma drugs acting on the adrenergic system (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1980, Volume: 176, Issue:4

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Drug Combinations; Epinephrine; Glaucoma; Guanethidine; Humans; Metoprolol; Timolol

1980
Beta blocking agents: current status in the prevention of sudden coronary death.
    Annals of the New York Academy of Sciences, 1982, Volume: 382

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Atenolol; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Practolol; Propranolol; Prospective Studies; Random Allocation; Timolol

1982
Forum: beta-adrenoreceptor blockade after acute myocardial infarction.
    Australian and New Zealand journal of medicine, 1982, Volume: 12, Issue:2

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Death, Sudden; Humans; Metoprolol; Myocardial Infarction; Propranolol; Recurrence; Timolol

1982
beta-Blockers and myocardial infarction.
    Archives of internal medicine, 1982, Volume: 142, Issue:9

    Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Clinical Trials as Topic; Death, Sudden; Diuretics; Humans; Hypertension; Metoprolol; Myocardial Infarction; Propranolol; Recurrence; Time Factors; Timolol

1982
Postinfarction therapy with beta blockers: who should be treated?
    International journal of cardiology, 1982, Volume: 1, Issue:5-6

    Topics: Adrenergic beta-Antagonists; Alprenolol; Clinical Trials as Topic; Double-Blind Method; Heart; Humans; Metoprolol; Myocardial Infarction; Propranolol; Random Allocation; Timolol

1982
Secondary prevention with beta-adrenoceptor blockers in post-myocardial infarction patients.
    American heart journal, 1982, Volume: 104, Issue:6

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Double-Blind Method; Humans; Metoprolol; Myocardial Infarction; Oxprenolol; Practolol; Propranolol; Recurrence; Sotalol; Timolol

1982
Beta-adrenergic blocking agents after myocardial infarction: an undocumented need in patients at lowest risk.
    Journal of the American College of Cardiology, 1983, Volume: 1, Issue:6

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Humans; Metoprolol; Myocardial Infarction; Propranolol; Research Design; Risk; Time Factors; Timolol

1983
Beta blockers in ischemic heart disease.
    The American journal of cardiology, 1983, Jul-20, Volume: 52, Issue:2

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Humans; Metoprolol; Myocardial Infarction; Prospective Studies; Random Allocation; Timolol

1983
Chronic beta blockade therapy in patients after myocardial infarction.
    The American journal of cardiology, 1983, Oct-01, Volume: 52, Issue:7

    Topics: Adrenergic beta-Antagonists; Aged; Alprenolol; Clinical Trials as Topic; Double-Blind Method; Humans; Metoprolol; Myocardial Infarction; Practolol; Propranolol; Timolol

1983
[Use of adrenergic beta blockaders after myocardial infarction].
    Arquivos brasileiros de cardiologia, 1983, Volume: 40, Issue:2

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Humans; Metoprolol; Myocardial Infarction; Propranolol; Timolol

1983
[Beta receptor blockers and calcium antagonists in coronary disease. Differential therapeutic aspects].
    Deutsche medizinische Wochenschrift (1946), 1983, Jul-29, Volume: 108, Issue:30

    Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Humans; Metoprolol; Middle Aged; Myocardial Infarction; Oxygen Consumption; Placebos; Prognosis; Propranolol; Timolol

1983
[Improved prognosis using beta blockers after myocardial infarct?].
    Lebensversicherungs Medizin, 1984, Jan-01, Volume: 36, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Oxprenolol; Prognosis; Propranolol; Sotalol; Timolol

1984
Prophylactic use of beta-adrenergic blockade in survivors of myocardial infarction.
    Heart & lung : the journal of critical care, 1984, Volume: 13, Issue:4

    Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Death, Sudden; Humans; Metoprolol; Myocardial Infarction; Propranolol; Recurrence; Timolol

1984
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
    Current problems in cardiology, 1984, Volume: 9, Issue:3

    Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans; Hypertension; Metoprolol; Myocardial Infarction; Oxprenolol; Pindolol; Practolol; Propranolol; Receptors, Adrenergic, beta; Risk; Sotalol; Timolol

1984
[Therapeutic value of the long-term administration of beta-adrenergic blockaders after myocardial infarct].
    Vutreshni bolesti, 1984, Volume: 23, Issue:3

    Topics: Adrenergic beta-Antagonists; Alprenolol; Clinical Trials as Topic; Humans; Metoprolol; Myocardial Infarction; Placebos; Practolol; Propranolol; Random Allocation; Sotalol; Time Factors; Timolol

1984
Short- and long-term influence of beta-adrenergic antagonists after acute myocardial infarction.
    The American journal of cardiology, 1984, Dec-21, Volume: 54, Issue:11

    Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Clinical Trials as Topic; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Humans; Metoprolol; Myocardial Infarction; Myocardium; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Time Factors; Timolol

1984
Beta-adrenoreceptor blocking agents. Their role in reducing chances of recurrent infarction and death.
    Archives of internal medicine, 1983, Volume: 143, Issue:9

    Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Propranolol; Recurrence; Sympatholytics; Timolol

1983
Timolol and metoprolol. A diurnal study of the ocular and systemic effects in glaucoma patients.
    Acta ophthalmologica, 1981, Volume: 59, Issue:4

    Topics: Aged; Blood Pressure; Circadian Rhythm; Clinical Trials as Topic; Double-Blind Method; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Propanolamines; Timolol

1981
Timolol and metoprolol in glaucoma. A comparison of the ocular hypotensive effect, local and systemic tolerance.
    Acta ophthalmologica, 1981, Volume: 59, Issue:3

    Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Glaucoma; Heart Rate; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Propanolamines; Timolol

1981
A diurnal study of the ocular hypotensive effect of metoprolol mounted on ophthalmic rods compared to timolol eye drops in glaucoma patients.
    Acta ophthalmologica, 1981, Volume: 59, Issue:4

    Topics: Aged; Blood Pressure; Circadian Rhythm; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Ophthalmic Solutions; Propanolamines; Timolol

1981
Initial and long-term effects of metoprolol and timolol on the intraocular pressure. A comparison in healthy subjects.
    Acta ophthalmologica, 1981, Volume: 59, Issue:4

    Topics: Adult; Double-Blind Method; Female; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Propanolamines; Random Allocation; Tears; Timolol

1981
Randomised training after myocardial infarction: short and long-term effects of exercise training after myocardial infarction in patients on beta-blocker treatment. A randomized, controlled study.
    Scandinavian cardiovascular journal : SCJ, 2000, Volume: 34, Issue:1

    Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Electrocardiography; Exercise Test; Exercise Therapy; Female; Follow-Up Studies; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Time Factors; Timolol; Treatment Outcome

2000

Other Studies

82 other study(ies) available for timolol and metoprolol

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Female; Guinea Pigs; Heart Rate; Hydrogen Bonding; Imidazoles; In Vitro Techniques; Receptors, Adrenergic, beta; Solubility; Structure-Activity Relationship

1986
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:8

    Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Dihydroalprenolol; Female; Guinea Pigs; Indicators and Reagents; Lung; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Propanolamines; Stereoisomerism

1982
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:7

    Topics: Adrenergic alpha-Agonists; Animals; Female; Guinea Pigs; Heart; Imidazoles; Indicators and Reagents; Isoproterenol; Magnetic Resonance Spectroscopy; Receptors, Adrenergic; Receptors, Adrenergic, beta; Structure-Activity Relationship

1983
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
    Journal of medicinal chemistry, 1996, Jan-05, Volume: 39, Issue:1

    Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes

1996
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
    Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6

    Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water

2001
Cheminformatic models to predict binding affinities to human serum albumin.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids

2001
Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates.
    Journal of medicinal chemistry, 2002, Jan-17, Volume: 45, Issue:2

    Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Inactivation, Metabolic; Liver; Microsomes, Liver; Models, Biological; Permeability; Pharmacokinetics; Rats; Species Specificity

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors.
    British journal of pharmacology, 2005, Volume: 144, Issue:3

    Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Algorithms; Animals; Cell Line; CHO Cells; Cricetinae; Dioxoles; Humans; Propanolamines; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3

2005
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water

2005
A 3D-QSAR model for CYP2D6 inhibition in the aryloxypropanolamine series.
    Bioorganic & medicinal chemistry letters, 2005, Sep-01, Volume: 15, Issue:17

    Topics: Animals; Cytochrome P-450 CYP2D6 Inhibitors; Humans; Inhibitory Concentration 50; Models, Molecular; Propanolamines; Quantitative Structure-Activity Relationship; Substrate Specificity

2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Role of Tyr(356(7.43)) and Ser(190(4.57)) in antagonist binding in the rat beta1-adrenergic receptor.
    Journal of medicinal chemistry, 2006, Jun-15, Volume: 49, Issue:12

    Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Models, Molecular; Mutagenesis, Site-Directed; Propanolamines; Rats; Receptors, Adrenergic, beta-1; Serine; Stereoisomerism; Transfection; Tyrosine

2006
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
    Journal of medicinal chemistry, 2009, May-28, Volume: 52, Issue:10

    Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.
    Bioorganic & medicinal chemistry, 2020, 05-01, Volume: 28, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Repositioning; Drug Screening Assays, Antitumor; Humans; Melanoma; Molecular Docking Simulation; Molecular Structure; Propanols; Skin Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured

2020
Once-daily treatment of hypertension.
    British medical journal, 1976, Jul-24, Volume: 2, Issue:6029

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Hypertension; Metoprolol; Pindolol; Propranolol; Timolol

1976
Pindolol: a pharmacokinetic comparison with other beta-adrenoceptor blocking agents.
    Acta medica Scandinavica. Supplementum, 1977, Volume: 606

    Topics: Adrenergic beta-Antagonists; Alprenolol; Biological Availability; Half-Life; Humans; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Protein Binding; Sotalol; Timolol

1977
alpha-Methyldopa and beta-blockers in hypertension--a comparison of their haemodynamic effects.
    Clinical and experimental pharmacology & physiology. Supplement, 1978, Volume: 4

    Topics: Adrenergic beta-Antagonists; Alprenolol; Hemodynamics; Humans; Hypertension; Methyldopa; Metoprolol; Physical Exertion; Propranolol; Time Factors; Timolol

1978
Comparison of the effects of nine beta-adrenergic blocking agents on intraocular pressure in rabbits.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1979, Mar-05, Volume: 210, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Drug Tolerance; Ethanolamines; Intraocular Pressure; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Rabbits; Sotalol; Timolol

1979
Vasospastic phenomena in patients treated with beta-adrenoceptor blocking agents.
    Acta medica Scandinavica. Supplementum, 1979, Volume: 628

    Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Circulation; Cardiac Output; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propranolol; Raynaud Disease; Skin Temperature; Timolol

1979
Beta-blocker withdrawal syndrome.
    Lancet (London, England), 1979, Mar-10, Volume: 1, Issue:8115

    Topics: Humans; Metoprolol; Nifedipine; Propanolamines; Propranolol; Pyridines; Substance Withdrawal Syndrome; Timolol

1979
Screening and confirmatory analysis of beta-agonists, beta-antagonists and their metabolites in horse urine by capillary gas chromatography-mass spectrometry.
    Journal of chromatography, 1991, Apr-05, Volume: 564, Issue:2

    Topics: Administration, Oral; Animals; Clenbuterol; Doping in Sports; Gas Chromatography-Mass Spectrometry; Horses; Injections, Intravenous; Isoxsuprine; Metoprolol; Propranolol; Timolol

1991
Influence of topical and systemic beta-blockers on tear production.
    International ophthalmology, 1989, Volume: 13, Issue:1-2

    Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Betaxolol; Butoxamine; Drug Administration Routes; Injections, Intramuscular; Lacrimal Apparatus; Male; Metoprolol; Oxprenolol; Propanolamines; Propranolol; Rabbits; Time Factors; Timolol

1989
Serum potassium concentrations following succinylcholine in patients undergoing beta-adrenoceptor blocking therapy.
    Journal of clinical anesthesia, 1989, Volume: 1, Issue:5

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Blood Pressure; Heart Rate; Humans; Metoprolol; Middle Aged; Nadolol; Ophthalmic Solutions; Potassium; Propranolol; Succinylcholine; Time Factors; Timolol

1989
Are beta-adrenergic mechanisms involved in ocular hypotensive actions of adrenergic drugs?
    Ophthalmic research, 1985, Volume: 17, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Aqueous Humor; Butoxamine; Cats; Dihydroalprenolol; Female; Intraocular Pressure; Male; Metoprolol; Propanolamines; Propranolol; Timolol

1985
Comparison of the effects of adrenergic agonists and alpha-, beta 1-, beta 2-antagonists on the intraocular pressure and adenylate cyclase activity in the ciliary processes of the rabbit.
    Acta ophthalmologica, 1985, Volume: 63, Issue:1

    Topics: Acebutolol; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Ciliary Body; Intraocular Pressure; Isoproterenol; Labetalol; Metoprolol; Rats; Timolol; Water

1985
Exercise training during chronic beta blockade in cardiovascular disease.
    The American journal of cardiology, 1985, Apr-26, Volume: 55, Issue:10

    Topics: Adrenergic beta-Antagonists; Atenolol; Coronary Artery Bypass; Female; Heart Rate; Humans; Male; Metoprolol; Myocardial Infarction; Nadolol; Physical Exertion; Propanolamines; Propranolol; Timolol

1985
Polymorphic metabolism of the beta-adrenoreceptor blocking drugs and its clinical relevance.
    European journal of clinical pharmacology, 1985, Volume: 28 Suppl

    Topics: Adrenergic beta-Antagonists; Animals; Biological Availability; Blood Pressure; Debrisoquin; Ethanolamines; Glucuronates; Humans; Hydroxylation; Kinetics; Lipids; Metoprolol; Phenotype; Polymorphism, Genetic; Propranolol; Solubility; Structure-Activity Relationship; Timolol

1985
Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol.
    Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Debrisoquin; Genetic Variation; Humans; Hypertension; Isoquinolines; Kinetics; Male; Metoprolol; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Propranolol; Structure-Activity Relationship; Timolol

1986
The effect of beta blockers on cardiac neural discharge associated with coronary occlusion in the cat.
    Journal of clinical pharmacology, 1987, Volume: 27, Issue:8

    Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Coronary Disease; Heart Rate; Metoprolol; Neurons; Practolol; Sympathetic Nervous System; Timolol

1987
Influence of some beta blockers (pindolol, atenolol, timolol and metoprolol) on aggregation and arachidonic acid metabolism in human platelets.
    Prostaglandins, leukotrienes, and medicine, 1987, Volume: 29, Issue:1

    Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Arachidonic Acid; Arachidonic Acids; Atenolol; Blood Platelets; Collagen; Epinephrine; Humans; Metoprolol; Phospholipids; Pindolol; Platelet Aggregation; Thromboxane B2; Timolol

1987
Stereospecificity of beta adrenergic antagonists: R-enantiomers show increased selectivity for beta-2 receptors in ciliary process.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1

    Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Betaxolol; Ciliary Body; Heart; Isoproterenol; Male; Metoprolol; Myocardium; Propanolamines; Rabbits; Receptors, Adrenergic, beta; Stereoisomerism; Structure-Activity Relationship; Timolol

1988
Differential effects of timolol and metoprolol on platelet function at rest and during exercise.
    European journal of clinical pharmacology, 1988, Volume: 33, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Blood Platelets; Double-Blind Method; Epinephrine; Exercise Test; Humans; Male; Metoprolol; Middle Aged; Norepinephrine; Physical Exertion; Platelet Count; Timolol

1988
Effects of atenolol and some other beta-adrenoceptor blocking agents on norepinephrine-induced responses in isolated and perfused rat hearts.
    Japanese journal of pharmacology, 1988, Volume: 47, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Heart; Heart Rate; In Vitro Techniques; Male; Metoprolol; Myocardial Contraction; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Timolol

1988
Adsorption of antihypertensives by suspensoids. Part 2. The adsorption of acebutolol, metoprolol, nadolol, oxprenolol, and timolol by attapulgite, charcoal, kaolin and magnesium trisilicate.
    Pharmaceutica acta Helvetiae, 1988, Volume: 63, Issue:1

    Topics: Acebutolol; Adsorption; Antihypertensive Agents; Charcoal; Kaolin; Magnesium; Magnesium Compounds; Magnesium Silicates; Metoprolol; Nadolol; Oxprenolol; Silicic Acid; Silicon; Silicon Compounds; Timolol

1988
Adrenergic drugs and intraocular pressure: suppression of ocular hypertension induced by water loading.
    Experimental eye research, 1980, Volume: 30, Issue:1

    Topics: Adrenergic beta-Antagonists; Animals; Butoxamine; Dobutamine; Ephedrine; Epinephrine; Intraocular Pressure; Isoproterenol; Male; Metoprolol; Propranolol; Pupil; Rabbits; Sympathomimetics; Terbutaline; Timolol; Water

1980
Ocular penetration of beta-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol.
    Documenta ophthalmologica. Advances in ophthalmology, 1980, Apr-15, Volume: 48, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Atenolol; Carbon Radioisotopes; Ciliary Body; Cornea; Eye; Female; Iris; Male; Metoprolol; Nictitating Membrane; Propranolol; Rabbits; Timolol; Tritium

1980
New beta-adrenergic blockers.
    American family physician, 1980, Volume: 22, Issue:2

    Topics: Adrenergic beta-Antagonists; Aged; Humans; Metoprolol; Nadolol; Propanolamines; Timolol

1980
Beta-blockers after myocardial infarction.
    The Medical letter on drugs and therapeutics, 1982, Apr-30, Volume: 24, Issue:608

    Topics: Adrenergic beta-Antagonists; Humans; Metoprolol; Myocardial Infarction; Propranolol; Timolol

1982
Managing angina with beta blockers.
    Geriatrics, 1982, Volume: 37, Issue:10

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Humans; Metoprolol; Nadolol; Nitrates; Propanolamines; Propranolol; Timolol

1982
Additive intraocular pressure reducing effect of topical timolol during systemic beta-blockade.
    Acta ophthalmologica, 1982, Volume: 60, Issue:1

    Topics: Administration, Oral; Administration, Topical; Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Blood Pressure; Female; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Propanolamines; Timolol

1982
Secondary prevention after myocardial infarction.
    Advances in cardiology, 1982, Volume: 31

    Topics: Adrenergic beta-Antagonists; Coronary Disease; Humans; Metoprolol; Myocardial Infarction; Prognosis; Propranolol; Timolol

1982
Central haemodynamic effects of beta blockers in hypertension. A comparison between atenolol, metoprolol, timolol, penbutolol, alprenolol pindolol and bunitrolol.
    European heart journal, 1983, Volume: 4 Suppl D

    Topics: Adrenergic beta-Antagonists; Alprenolol; Atenolol; Hemodynamics; Humans; Hypertension; Metoprolol; Pindolol; Propanolamines; Time Factors; Timolol

1983
Essential hypertension. The behaviour of the haemorheological determinants and their trends during beta-blocker treatment.
    Japanese heart journal, 1983, Volume: 24, Issue:5

    Topics: Adrenergic beta-Antagonists; Aged; Blood Proteins; Blood Viscosity; Female; Fibrinogen; Hematocrit; Humans; Hypertension; Male; Metoprolol; Middle Aged; Serum Albumin; Timolol

1983
Beta-blockers in isoproterenol-enhanced essential tremor.
    Acta neurologica Scandinavica, 1984, Volume: 69, Issue:2

    Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Humans; Isoproterenol; Metoprolol; Middle Aged; Propranolol; Timolol; Tremor

1984
Beta-adrenergic antagonist inhibition of hepatic 3,5,3'-triiodothyronine production.
    Endocrinology, 1984, Volume: 115, Issue:3

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atenolol; Dithiothreitol; Liver; Male; Metoprolol; Nadolol; Pindolol; Propanolamines; Propranolol; Rats; Rats, Inbred Strains; Timolol; Triiodothyronine

1984
Beta-adrenergic blockers. Choosing among them.
    Postgraduate medicine, 1984, Sep-01, Volume: 76, Issue:3

    Topics: Adrenergic beta-Antagonists; Atenolol; Cardiovascular Diseases; Humans; Kinetics; Metoprolol; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol

1984
Comparative effects of propranolol, timolol and metoprolol on myocardial infarct size after experimental coronary artery occlusion.
    Journal of the American College of Cardiology, 1984, Volume: 4, Issue:4

    Topics: Animals; Blood Pressure; Coronary Circulation; Dogs; Fatty Acids, Nonesterified; Female; Heart Rate; Male; Metoprolol; Myocardial Infarction; Myocardium; Oxygen Consumption; Propranolol; Timolol

1984
Effects of the (+/-)-, (+)- and (-)-forms of propranolol, timolol and metoprolol on noradrenergic transmission in the rat isolated right ventricle.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 270, Issue:1

    Topics: Animals; Drug Interactions; Electric Stimulation; Heart Ventricles; In Vitro Techniques; Isomerism; Male; Metoprolol; Myocardial Contraction; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Stimulation, Chemical; Timolol; Tritium

1984
Gas chromatography with nitrogen-selective detection of metoprolol from human plasma after reaction with phosgene.
    Journal of chromatography, 1983, Mar-11, Volume: 273, Issue:1

    Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Metoprolol; Phosgene; Propanolamines; Timolol

1983
Newer antihypertensive agents.
    Comprehensive therapy, 1980, Volume: 6, Issue:3

    Topics: Aged; Antihypertensive Agents; Captopril; Diuretics; Humans; Hypertension; Male; Metoprolol; Middle Aged; Mineralocorticoid Receptor Antagonists; Pindolol; Saralasin; Timolol; United States; Vasoconstrictor Agents

1980
[Comparative clinical study of metoprolol and timolol (author's transl)].
    Journal francais d'ophtalmologie, 1981, Volume: 4, Issue:4

    Topics: Glaucoma; Humans; Intraocular Pressure; Metoprolol; Propanolamines; Time Factors; Timolol; Vasoconstriction

1981
[Drug therapy of angina pectoris. Are the possibilities exploited well enough?].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1995, Aug-10, Volume: 115, Issue:18

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Angina, Unstable; Female; Humans; Isosorbide Dinitrate; Male; Metoprolol; Middle Aged; Propranolol; Retrospective Studies; Timolol

1995
[Beta-receptor blockers after revascularization in coronary sclerosis].
    Deutsche medizinische Wochenschrift (1946), 1995, Sep-15, Volume: 120, Issue:37

    Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Coronary Artery Bypass; Coronary Disease; Humans; Male; Metoprolol; Multicenter Studies as Topic; Myocardial Infarction; Propranolol; Recurrence; Time Factors; Timolol

1995
Evaluation of the immobilized artificial membrane phosphatidylcholine. Drug discovery column for high-performance liquid chromatographic screening of drug-membrane interactions.
    Journal of chromatography. A, 1998, Mar-27, Volume: 800, Issue:2

    Topics: Acebutolol; Acetonitriles; Adrenergic beta-Antagonists; Alprenolol; Aniline Compounds; Atenolol; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Membranes, Artificial; Metoprolol; Models, Chemical; Osmolar Concentration; Oxprenolol; Phosphatidylcholines; Pindolol; Propranolol; Reproducibility of Results; Timolol

1998
In vitro permeability of eight beta-blockers through Caco-2 monolayers utilizing liquid chromatography/electrospray ionization mass spectrometry.
    Journal of mass spectrometry : JMS, 1998, Volume: 33, Issue:7

    Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Atenolol; Biological Availability; Caco-2 Cells; Cell Membrane Permeability; Chromatography, Liquid; Epithelial Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Mass Spectrometry; Metoprolol; Molecular Structure; Oxprenolol; Pindolol; Propranolol; Research Design; Timolol

1998
Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose.
    Journal of the American Geriatrics Society, 1999, Volume: 47, Issue:8

    Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Atenolol; Chlorthalidone; Confidence Intervals; Databases as Topic; Diuretics; Drug Compounding; Evaluation Studies as Topic; Female; Humans; Hydrochlorothiazide; Logistic Models; Male; Metolazone; Metoprolol; Myocardial Infarction; Odds Ratio; Ontario; Propranolol; Retrospective Studies; Sex Factors; Sodium Chloride Symporter Inhibitors; Timolol

1999
Beta-adrenergic signalling and threshold adrenaline concentration for induction of fibrillation in the perfused heart pretreated with antihypertensive drugs.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1999, Volume: 199, Issue:3

    Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Cyclic AMP; Enalapril; Epinephrine; GTP-Binding Proteins; In Vitro Techniques; Male; Metoprolol; Perfusion; Potassium; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Signal Transduction; Timolol; Verapamil

1999
Comparison of the neuroprotective effects of adrenoceptor drugs in retinal cell culture and intact retina.
    Investigative ophthalmology & visual science, 2002, Volume: 43, Issue:8

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Brimonidine Tartrate; Calcium; Cell Culture Techniques; Cell Survival; Dose-Response Relationship, Drug; Fura-2; Glutamic Acid; Metoprolol; N-Methylaspartate; Neuroglia; Neuroprotective Agents; Quinoxalines; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Timolol

2002
Polymeric matrix membrane sensors for sensitive potentiometric determination of some beta-blockers in pharmaceutical preparations.
    Journal of pharmaceutical and biomedical analysis, 2003, Apr-24, Volume: 32, Issue:1

    Topics: Adrenergic beta-Antagonists; Atenolol; Bisoprolol; Indicators and Reagents; Ions; Metoprolol; Phosphates; Polyvinyl Chloride; Potentiometry; Propranolol; Sensitivity and Specificity; Timolol; Tungsten Compounds

2003
Iontophoretic in vivo transdermal delivery of beta-blockers in hairless rats and reduced skin irritation by liposomal formulation.
    Pharmaceutical research, 2003, Volume: 20, Issue:9

    Topics: Administration, Cutaneous; Adrenergic beta-Antagonists; Animals; Biological Transport; Chromatography, High Pressure Liquid; Drug Carriers; Injections, Intravenous; Iontophoresis; Irritants; Liposomes; Metoprolol; Oxprenolol; Propranolol; Rats; Skin; Skin Absorption; Sotalol; Stereoisomerism; Timolol

2003
Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: assessment of nonlinearity of metoprolol, timolol, and propranolol.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:12

    Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; Blood Proteins; Drug Design; Female; Male; Metabolic Clearance Rate; Metoprolol; Microsomes, Liver; Nonlinear Dynamics; Predictive Value of Tests; Propranolol; Rats; Rats, Wistar; Substrate Specificity; Timolol

2005
Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach.
    Journal of pharmaceutical sciences, 2009, Volume: 98, Issue:10

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Algorithms; Animals; Blood Proteins; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Metoprolol; Models, Biological; Propranolol; Protein Binding; Rats; Rats, Inbred WKY; Receptors, Adrenergic, beta; Timolol

2009