timolol has been researched along with metoprolol in 124 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 77 (62.10) | 18.7374 |
| 1990's | 9 (7.26) | 18.2507 |
| 2000's | 28 (22.58) | 29.6817 |
| 2010's | 9 (7.26) | 24.3611 |
| 2020's | 1 (0.81) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Baldwin, JJ; Christy, ME; Denny, GH; Freedman, MB; Gross, DM; Habecker, CN; Lyle, PA; Ponticello, GS; Sweet, CS; Varga, SL | 1 |
| Carrupt, PA; el Tayar, N; Testa, B; Van de Waterbeemd, H | 1 |
| Baldwin, JJ; Gross, DM; McClure, DE; Williams, M | 1 |
| Baldwin, JJ; Denny, GH; Freedman, MB; Gross, DM; Hirschmann, R; Ponticello, GS; Sweet, CS | 1 |
| Carrupt, PA; Gaillard, P; Schambel, P; Testa, B | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Hwang, KK; Mandagere, AK; Thompson, TN | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Baker, JG | 1 |
| Caron, G; Ermondi, G | 1 |
| Chandrasena, G; Gavai, AV; Nayeem, A; Santone, K; Vaz, RJ | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Duke, BJ; Jackman, GP; Louis, SN; Louis, WJ; Machida, CA; Nero, TL; Rezmann-Vitti, LA | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Bard, B; Carrupt, PA; Martel, S | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Chang, Q; Chen, Z; Hu, G; Hu, L; Li, Q; Long, J | 1 |
| Meier, J | 1 |
| Lund-Johansen, P | 2 |
| Kiechel, JR; Meier, J | 1 |
| Bellucci, R; Bonomi, L; Massa, F; Noya, E; Perfetti, S | 1 |
| Anderton, RC; Frith, PA; Hargreave, FE; Kumana, CR; Newhouse, MT; Ruffin, RE | 1 |
| Eliasson, K; Lins, LE; Sundqvist, K | 1 |
| Lederballe Pedersen, O; Mikkelsen, E | 1 |
| Bousser, MG; Massiou, H | 1 |
| Dumasia, MC; Houghton, E | 1 |
| Akritopoulos, P; Petounis, AD | 1 |
| From, RP; Mehta, MP; Pathak, D | 1 |
| Dolva, LO; Eide, I; Gullestad, L; Kjekshus, J; Kjeldsen, SE | 1 |
| Chiou, GC; Liu, HK; McLaughlin, MA; Watanabe, K | 1 |
| Palkama, A; Raij, K; Uusitalo, H; Uusitalo, R | 1 |
| Fletcher, GF | 1 |
| Lennard, MS | 1 |
| Smith, RL | 1 |
| Fishbein, L; Jackson, CD | 1 |
| Halawa, B; Mazurek, W | 1 |
| Lennard, MS; Silas, JH; Tucker, GT; Woods, HF | 1 |
| Tfelt-Hansen, P | 1 |
| Lathers, CM; Spivey, WH | 1 |
| Srivastava, KC | 1 |
| Nathanson, JA | 1 |
| Eldrup, E; Jørgensen, EO; Knudsen, JB; Winther, K | 1 |
| Kato, T; Nagamine, F; Nakasone, J; Noguchi, K; Sakanashi, M | 1 |
| Dolva, LO; Gullestad, L; Kjekshus, J; Søyland, E | 1 |
| al-Gohary, O; Lyal, J; Murray, JB | 1 |
| Vidt, DG | 1 |
| Potter, DE; Rowland, JM | 1 |
| Johansson, SR; McCall, M; Vedin, JA; Wilhelmsson, C | 1 |
| Innemee, HC; Ros, FE; van Zwieten, PA | 1 |
| Lowenthal, DT | 1 |
| Aeschlimann, J; Bucheli, J; Eltz, H; Gloor, B; Urner-Bloch, U | 1 |
| Frishman, WH; Koch-Weser, J | 1 |
| Borer, JS; Moses, JW | 1 |
| Hjalmarson, A | 1 |
| Gorlin, R; Moser, M | 1 |
| Iskandrian, AS; Kotler, MN; Segal, BL | 1 |
| Moss, AJ | 1 |
| Alvan, G; Calissendorff, BM; Haglund, K; Marén, N; Seideman, P | 1 |
| Amery, A; Bulpitt, C; Cattaert, A; Fagard, R; Staessen, J; Vanhees, L | 1 |
| Julian, DG | 1 |
| Gettes, LS; Griggs, TR; Wagner, GS | 1 |
| Vedin, A; Wilhelmsson, C | 1 |
| Pratt, CM; Roberts, R | 1 |
| Ribeiro, LG | 1 |
| Delius, W | 1 |
| Weisswange, A | 1 |
| Caimi, G; Capobianco, D; Catania, A; Frazzetta, F; Sarno, A | 1 |
| Teräväinen, H | 1 |
| Jackson, EA; Sullman, SA | 1 |
| Ferguson, RK; Rotmensch, HH; Vlasses, PH | 1 |
| Chung, DC; Laschuk, MJ | 1 |
| Friedewald, WT; Frishman, WH; Furberg, CD | 1 |
| Peele, ME; Shulkin, BL; Utiger, RD | 1 |
| Tomov, I | 1 |
| McGoon, MD; Vlietstra, RE | 1 |
| Buja, LM; Willerson, JT | 1 |
| Clusin, WT; Gillis, AM | 1 |
| Khan, AH | 1 |
| Maroko, PR; Ribeiro, LG; Vik-Mo, H | 1 |
| Bradley, L; Doggrell, SA | 1 |
| Gyllenhaal, O; Vessman, J | 1 |
| Thind, GS | 1 |
| Eriksen, JS; Nielsen, NV | 2 |
| Nielsen, NV | 1 |
| Collignon-Brach, J; Weekers, R | 1 |
| Alm, A; Törnquist, P; Wickström, CP | 1 |
| Forfang, K; Gullestad, L | 1 |
| Osterziel, KJ | 1 |
| Caldwell, GW; Evangelisto, M; Masucci, JA; White, R | 1 |
| Caldwell, GW; Demarest, K; Easlick, SM; Gunnet, J; Masucci, JA | 1 |
| Anderson, GM; Clark, JP; Gurwitz, JH; Lau, P; Rochon, PA; Shear, NH; Tu, JV | 1 |
| Gordeladze, JO; Jynge, P; Sellevold, OF | 1 |
| Dale, J; Heldal, M; Sire, S | 1 |
| Baldridge, WH; Baptiste, DC; Chauhan, BC; Hartwick, AT; Jollimore, CA; Kelly, ME; Tremblay, F | 1 |
| Abou-Sekkina, MM; El-Ries, MA; Hassan, SS; Wassel, A | 1 |
| Banga, AK; Betageri, GV; Chaturvedula, A; Conjeevaram, R; Sunkara, G | 1 |
| Iwaki, M; Kawase, A; Komura, H | 1 |
| Borer, JS; Camm, AJ; Danchin, N; Ferrari, R; Fox, K; Lopez Sendon, JL; Steg, PG; Tardif, JC; Tavazzi, L; Tendera, M | 1 |
| Arstall, MA; Beltrame, JF; Horowitz, JD; Zeitz, CJ | 1 |
| Boralli, VB; Danhof, M; de Lange, EC; Freijer, J; Krekels, EH; Slijkerman, P; van Steeg, TJ | 1 |
19 review(s) available for timolol and metoprolol
| Article | Year |
|---|---|
Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Models, Molecular; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1988 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Comparative pharmacokinetics of beta-blockers].
Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Half-Life; Humans; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Sotalol; Timolol | 1978 |
[Beta-blockers and migraine].
Topics: Adrenergic beta-Antagonists; Atenolol; Clinical Trials as Topic; Dilatation, Pathologic; Evoked Potentials, Visual; Humans; Metoprolol; Migraine Disorders; Nadolol; Platelet Aggregation; Propranolol; Receptors, Serotonin; Timolol | 1992 |
Oxidation phenotype and the metabolism and action of beta-blockers.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Drug Interactions; Ethanolamines; Humans; Hypertension; Kinetics; Metoprolol; Oxidation-Reduction; Phenotype; Propranolol; Timolol | 1985 |
A toxicological review of beta-adrenergic blockers.
Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Cocarcinogenesis; Ethanolamines; Female; Kinetics; Labetalol; Lethal Dose 50; Male; Metoprolol; Mice; Mutagens; Nadolol; Neoplasms, Experimental; Oxprenolol; Pindolol; Practolol; Propanolamines; Propranolol; Rats; Sotalol; Timolol | 1986 |
[Effect of beta-adrenolytic drugs on the survival of patients after myocardial infarction].
Topics: Adrenergic beta-Antagonists; Adult; Aftercare; Aged; Clinical Trials as Topic; Follow-Up Studies; Humans; Metoprolol; Middle Aged; Myocardial Infarction; Oxprenolol; Propranolol; Time Factors; Timolol | 1986 |
Advances in the medical management of renovascular hypertension.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteriosclerosis; Atenolol; Captopril; Dipeptides; Enalapril; Female; Humans; Hypertension, Renovascular; Male; Metoprolol; Middle Aged; Nadolol; Pindolol; Propanolamines; Propranolol; Renal Artery Obstruction; Renin-Angiotensin System; Saralasin; Timolol | 1984 |
beta-Adrenoceptor antagonists: new drugs and new indications.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Glaucoma; Humans; Hypertension; Kinetics; Metoprolol; Migraine Disorders; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol | 1981 |
Beta-adrenergic antagonists in the treatment of patients with heart disease.
Topics: Acebutolol; Adrenergic beta-Agonists; Alprenolol; Animals; Arrhythmias, Cardiac; Bronchial Spasm; Cardiomyopathy, Hypertrophic; Coronary Disease; Female; Heart Diseases; Heart Failure; Humans; Hypertension; Metoprolol; Mitral Valve Prolapse; Mitral Valve Stenosis; Nadolol; Nervous System Diseases; Pindolol; Pregnancy; Pregnancy Complications, Cardiovascular; Propanolamines; Propranolol; Receptors, Adrenergic, beta; Structure-Activity Relationship; Timolol | 1981 |
Beta blocking agents: current status in the prevention of sudden coronary death.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Atenolol; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Practolol; Propranolol; Prospective Studies; Random Allocation; Timolol | 1982 |
Comparative review of beta-blocking agents.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Atenolol; Humans; Hypertension; Metoprolol; Migraine Disorders; Myocardial Infarction; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol | 1984 |
The new beta-adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Atenolol; Humans; Labetalol; Metoprolol; Nadolol; Oxprenolol; Pindolol; Propanolamines; Timolol | 1984 |
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans; Hypertension; Metoprolol; Myocardial Infarction; Oxprenolol; Pindolol; Practolol; Propranolol; Receptors, Adrenergic, beta; Risk; Sotalol; Timolol | 1984 |
[Therapeutic value of the long-term administration of beta-adrenergic blockaders after myocardial infarct].
Topics: Adrenergic beta-Antagonists; Alprenolol; Clinical Trials as Topic; Humans; Metoprolol; Myocardial Infarction; Placebos; Practolol; Propranolol; Random Allocation; Sotalol; Time Factors; Timolol | 1984 |
Short- and long-term influence of beta-adrenergic antagonists after acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Clinical Trials as Topic; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Humans; Metoprolol; Myocardial Infarction; Myocardium; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Time Factors; Timolol | 1984 |
The role of beta-adrenergic receptor antagonists in the prevention of sudden cardiac death.
Topics: Action Potentials; Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Cardiac Complexes, Premature; Coronary Disease; Drug Therapy, Combination; Humans; Metoprolol; Myocardial Infarction; Propranolol; Recurrence; Time Factors; Timolol | 1984 |
Resting heart rate in cardiovascular disease.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Carbazoles; Cardiac Output, Low; Cardiovascular Diseases; Carvedilol; Coronary Artery Disease; Coronary Disease; Exercise Test; Heart Rate; Humans; Metoprolol; Multivariate Analysis; Myocardial Infarction; Myocardial Ischemia; Prognosis; Propanolamines; Risk Assessment; Risk Factors; Timolol; Ventricular Dysfunction, Left | 2007 |
Is there still a role for treatment with beta-adrenoceptor antagonists in post-myocardial infarction patients with well-preserved left ventricular systolic function?
Topics: Adrenergic Antagonists; Angioplasty, Balloon, Coronary; Endothelium, Vascular; Humans; Metoprolol; Myocardial Infarction; Propranolol; Thrombolytic Therapy; Timolol; Ventricular Function, Left | 2008 |
29 trial(s) available for timolol and metoprolol
| Article | Year |
|---|---|
Selectivity of beta adrenoreceptor antagonist drugs assessed by histamine bronchial provocation.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Airway Resistance; Asthma; Double-Blind Method; Drug Interactions; Female; Forced Expiratory Volume; Histamine; Humans; Male; Metoprolol; Middle Aged; Organ Specificity; Propranolol; Pulse; Timolol | 1979 |
[Beta-blockers and migraine].
Topics: Adrenergic beta-Antagonists; Atenolol; Clinical Trials as Topic; Dilatation, Pathologic; Evoked Potentials, Visual; Humans; Metoprolol; Migraine Disorders; Nadolol; Platelet Aggregation; Propranolol; Receptors, Serotonin; Timolol | 1992 |
Effect of beta-adrenergic blockade on hormonal responses during continuous and intermittent exercise.
Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Blood Pressure; Dopamine; Epinephrine; Exercise; Fatigue; Fatty Acids, Nonesterified; Growth Hormone; Heart Rate; Hormones; Humans; Hydrocortisone; Male; Metoprolol; Middle Aged; Norepinephrine; Prolactin; Renin; Timolol | 1989 |
[Effect of beta-adrenolytic drugs on the survival of patients after myocardial infarction].
Topics: Adrenergic beta-Antagonists; Adult; Aftercare; Aged; Clinical Trials as Topic; Follow-Up Studies; Humans; Metoprolol; Middle Aged; Myocardial Infarction; Oxprenolol; Propranolol; Time Factors; Timolol | 1986 |
Efficacy of beta-blockers in migraine. A critical review.
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Double-Blind Method; Humans; Metoprolol; Migraine Disorders; Nadolol; Propranolol; Racemases and Epimerases; Timolol | 1986 |
Difference between beta-1-selective and non-selective beta-blockade during continuous and intermittent exercise.
Topics: Administration, Oral; Adult; Blood Pressure; Double-Blind Method; Exercise; Humans; Male; Metoprolol; Middle Aged; Oxygen Consumption; Physical Endurance; Potassium; Random Allocation; Timolol | 1988 |
Duration of action of beta blockers.
Topics: Adrenergic beta-Antagonists; Adult; Alprenolol; Atenolol; Blood Pressure; Coronary Disease; Heart Rate; Humans; Metoprolol; Penbutolol; Physical Exertion; Pindolol; Propranolol; Regression Analysis; Rest; Sotalol; Time Factors; Timolol | 1980 |
[Clinical trials of various glaucoma drugs acting on the adrenergic system (author's transl)].
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Drug Combinations; Epinephrine; Glaucoma; Guanethidine; Humans; Metoprolol; Timolol | 1980 |
Beta blocking agents: current status in the prevention of sudden coronary death.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Atenolol; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Practolol; Propranolol; Prospective Studies; Random Allocation; Timolol | 1982 |
Forum: beta-adrenoreceptor blockade after acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Death, Sudden; Humans; Metoprolol; Myocardial Infarction; Propranolol; Recurrence; Timolol | 1982 |
beta-Blockers and myocardial infarction.
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Clinical Trials as Topic; Death, Sudden; Diuretics; Humans; Hypertension; Metoprolol; Myocardial Infarction; Propranolol; Recurrence; Time Factors; Timolol | 1982 |
Postinfarction therapy with beta blockers: who should be treated?
Topics: Adrenergic beta-Antagonists; Alprenolol; Clinical Trials as Topic; Double-Blind Method; Heart; Humans; Metoprolol; Myocardial Infarction; Propranolol; Random Allocation; Timolol | 1982 |
Secondary prevention with beta-adrenoceptor blockers in post-myocardial infarction patients.
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Double-Blind Method; Humans; Metoprolol; Myocardial Infarction; Oxprenolol; Practolol; Propranolol; Recurrence; Sotalol; Timolol | 1982 |
Beta-adrenergic blocking agents after myocardial infarction: an undocumented need in patients at lowest risk.
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Humans; Metoprolol; Myocardial Infarction; Propranolol; Research Design; Risk; Time Factors; Timolol | 1983 |
Beta blockers in ischemic heart disease.
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Humans; Metoprolol; Myocardial Infarction; Prospective Studies; Random Allocation; Timolol | 1983 |
Chronic beta blockade therapy in patients after myocardial infarction.
Topics: Adrenergic beta-Antagonists; Aged; Alprenolol; Clinical Trials as Topic; Double-Blind Method; Humans; Metoprolol; Myocardial Infarction; Practolol; Propranolol; Timolol | 1983 |
[Use of adrenergic beta blockaders after myocardial infarction].
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Humans; Metoprolol; Myocardial Infarction; Propranolol; Timolol | 1983 |
[Beta receptor blockers and calcium antagonists in coronary disease. Differential therapeutic aspects].
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Humans; Metoprolol; Middle Aged; Myocardial Infarction; Oxygen Consumption; Placebos; Prognosis; Propranolol; Timolol | 1983 |
[Improved prognosis using beta blockers after myocardial infarct?].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Oxprenolol; Prognosis; Propranolol; Sotalol; Timolol | 1984 |
Prophylactic use of beta-adrenergic blockade in survivors of myocardial infarction.
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Death, Sudden; Humans; Metoprolol; Myocardial Infarction; Propranolol; Recurrence; Timolol | 1984 |
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans; Hypertension; Metoprolol; Myocardial Infarction; Oxprenolol; Pindolol; Practolol; Propranolol; Receptors, Adrenergic, beta; Risk; Sotalol; Timolol | 1984 |
[Therapeutic value of the long-term administration of beta-adrenergic blockaders after myocardial infarct].
Topics: Adrenergic beta-Antagonists; Alprenolol; Clinical Trials as Topic; Humans; Metoprolol; Myocardial Infarction; Placebos; Practolol; Propranolol; Random Allocation; Sotalol; Time Factors; Timolol | 1984 |
Short- and long-term influence of beta-adrenergic antagonists after acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Animals; Catecholamines; Clinical Trials as Topic; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Humans; Metoprolol; Myocardial Infarction; Myocardium; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Time Factors; Timolol | 1984 |
Beta-adrenoreceptor blocking agents. Their role in reducing chances of recurrent infarction and death.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Propranolol; Recurrence; Sympatholytics; Timolol | 1983 |
Timolol and metoprolol. A diurnal study of the ocular and systemic effects in glaucoma patients.
Topics: Aged; Blood Pressure; Circadian Rhythm; Clinical Trials as Topic; Double-Blind Method; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Propanolamines; Timolol | 1981 |
Timolol and metoprolol in glaucoma. A comparison of the ocular hypotensive effect, local and systemic tolerance.
Topics: Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Glaucoma; Heart Rate; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Propanolamines; Timolol | 1981 |
A diurnal study of the ocular hypotensive effect of metoprolol mounted on ophthalmic rods compared to timolol eye drops in glaucoma patients.
Topics: Aged; Blood Pressure; Circadian Rhythm; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Ophthalmic Solutions; Propanolamines; Timolol | 1981 |
Initial and long-term effects of metoprolol and timolol on the intraocular pressure. A comparison in healthy subjects.
Topics: Adult; Double-Blind Method; Female; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Propanolamines; Random Allocation; Tears; Timolol | 1981 |
Randomised training after myocardial infarction: short and long-term effects of exercise training after myocardial infarction in patients on beta-blocker treatment. A randomized, controlled study.
Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Electrocardiography; Exercise Test; Exercise Therapy; Female; Follow-Up Studies; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Time Factors; Timolol; Treatment Outcome | 2000 |
82 other study(ies) available for timolol and metoprolol
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2.
Topics: Adrenergic beta-Antagonists; Animals; Female; Guinea Pigs; Heart Rate; Hydrogen Bonding; Imidazoles; In Vitro Techniques; Receptors, Adrenergic, beta; Solubility; Structure-Activity Relationship | 1986 |
Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.
Topics: Adrenergic beta-Antagonists; Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Dihydroalprenolol; Female; Guinea Pigs; Indicators and Reagents; Lung; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Propanolamines; Stereoisomerism | 1982 |
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.
Topics: Adrenergic alpha-Agonists; Animals; Female; Guinea Pigs; Heart; Imidazoles; Indicators and Reagents; Isoproterenol; Magnetic Resonance Spectroscopy; Receptors, Adrenergic; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1983 |
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Inactivation, Metabolic; Liver; Microsomes, Liver; Models, Biological; Permeability; Pharmacokinetics; Rats; Species Specificity | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Algorithms; Animals; Cell Line; CHO Cells; Cricetinae; Dioxoles; Humans; Propanolamines; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3 | 2005 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A 3D-QSAR model for CYP2D6 inhibition in the aryloxypropanolamine series.
Topics: Animals; Cytochrome P-450 CYP2D6 Inhibitors; Humans; Inhibitory Concentration 50; Models, Molecular; Propanolamines; Quantitative Structure-Activity Relationship; Substrate Specificity | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Role of Tyr(356(7.43)) and Ser(190(4.57)) in antagonist binding in the rat beta1-adrenergic receptor.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Models, Molecular; Mutagenesis, Site-Directed; Propanolamines; Rats; Receptors, Adrenergic, beta-1; Serine; Stereoisomerism; Transfection; Tyrosine | 2006 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Repositioning; Drug Screening Assays, Antitumor; Humans; Melanoma; Molecular Docking Simulation; Molecular Structure; Propanols; Skin Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Once-daily treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Hypertension; Metoprolol; Pindolol; Propranolol; Timolol | 1976 |
Pindolol: a pharmacokinetic comparison with other beta-adrenoceptor blocking agents.
Topics: Adrenergic beta-Antagonists; Alprenolol; Biological Availability; Half-Life; Humans; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Protein Binding; Sotalol; Timolol | 1977 |
alpha-Methyldopa and beta-blockers in hypertension--a comparison of their haemodynamic effects.
Topics: Adrenergic beta-Antagonists; Alprenolol; Hemodynamics; Humans; Hypertension; Methyldopa; Metoprolol; Physical Exertion; Propranolol; Time Factors; Timolol | 1978 |
Comparison of the effects of nine beta-adrenergic blocking agents on intraocular pressure in rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Drug Tolerance; Ethanolamines; Intraocular Pressure; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Rabbits; Sotalol; Timolol | 1979 |
Vasospastic phenomena in patients treated with beta-adrenoceptor blocking agents.
Topics: Adrenergic beta-Antagonists; Alprenolol; Blood Circulation; Cardiac Output; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propranolol; Raynaud Disease; Skin Temperature; Timolol | 1979 |
Beta-blocker withdrawal syndrome.
Topics: Humans; Metoprolol; Nifedipine; Propanolamines; Propranolol; Pyridines; Substance Withdrawal Syndrome; Timolol | 1979 |
Screening and confirmatory analysis of beta-agonists, beta-antagonists and their metabolites in horse urine by capillary gas chromatography-mass spectrometry.
Topics: Administration, Oral; Animals; Clenbuterol; Doping in Sports; Gas Chromatography-Mass Spectrometry; Horses; Injections, Intravenous; Isoxsuprine; Metoprolol; Propranolol; Timolol | 1991 |
Influence of topical and systemic beta-blockers on tear production.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Betaxolol; Butoxamine; Drug Administration Routes; Injections, Intramuscular; Lacrimal Apparatus; Male; Metoprolol; Oxprenolol; Propanolamines; Propranolol; Rabbits; Time Factors; Timolol | 1989 |
Serum potassium concentrations following succinylcholine in patients undergoing beta-adrenoceptor blocking therapy.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Blood Pressure; Heart Rate; Humans; Metoprolol; Middle Aged; Nadolol; Ophthalmic Solutions; Potassium; Propranolol; Succinylcholine; Time Factors; Timolol | 1989 |
Are beta-adrenergic mechanisms involved in ocular hypotensive actions of adrenergic drugs?
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Aqueous Humor; Butoxamine; Cats; Dihydroalprenolol; Female; Intraocular Pressure; Male; Metoprolol; Propanolamines; Propranolol; Timolol | 1985 |
Comparison of the effects of adrenergic agonists and alpha-, beta 1-, beta 2-antagonists on the intraocular pressure and adenylate cyclase activity in the ciliary processes of the rabbit.
Topics: Acebutolol; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Ciliary Body; Intraocular Pressure; Isoproterenol; Labetalol; Metoprolol; Rats; Timolol; Water | 1985 |
Exercise training during chronic beta blockade in cardiovascular disease.
Topics: Adrenergic beta-Antagonists; Atenolol; Coronary Artery Bypass; Female; Heart Rate; Humans; Male; Metoprolol; Myocardial Infarction; Nadolol; Physical Exertion; Propanolamines; Propranolol; Timolol | 1985 |
Polymorphic metabolism of the beta-adrenoreceptor blocking drugs and its clinical relevance.
Topics: Adrenergic beta-Antagonists; Animals; Biological Availability; Blood Pressure; Debrisoquin; Ethanolamines; Glucuronates; Humans; Hydroxylation; Kinetics; Lipids; Metoprolol; Phenotype; Polymorphism, Genetic; Propranolol; Solubility; Structure-Activity Relationship; Timolol | 1985 |
Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Debrisoquin; Genetic Variation; Humans; Hypertension; Isoquinolines; Kinetics; Male; Metoprolol; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Propranolol; Structure-Activity Relationship; Timolol | 1986 |
The effect of beta blockers on cardiac neural discharge associated with coronary occlusion in the cat.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Coronary Disease; Heart Rate; Metoprolol; Neurons; Practolol; Sympathetic Nervous System; Timolol | 1987 |
Influence of some beta blockers (pindolol, atenolol, timolol and metoprolol) on aggregation and arachidonic acid metabolism in human platelets.
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Arachidonic Acid; Arachidonic Acids; Atenolol; Blood Platelets; Collagen; Epinephrine; Humans; Metoprolol; Phospholipids; Pindolol; Platelet Aggregation; Thromboxane B2; Timolol | 1987 |
Stereospecificity of beta adrenergic antagonists: R-enantiomers show increased selectivity for beta-2 receptors in ciliary process.
Topics: Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Betaxolol; Ciliary Body; Heart; Isoproterenol; Male; Metoprolol; Myocardium; Propanolamines; Rabbits; Receptors, Adrenergic, beta; Stereoisomerism; Structure-Activity Relationship; Timolol | 1988 |
Differential effects of timolol and metoprolol on platelet function at rest and during exercise.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Blood Platelets; Double-Blind Method; Epinephrine; Exercise Test; Humans; Male; Metoprolol; Middle Aged; Norepinephrine; Physical Exertion; Platelet Count; Timolol | 1988 |
Effects of atenolol and some other beta-adrenoceptor blocking agents on norepinephrine-induced responses in isolated and perfused rat hearts.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Heart; Heart Rate; In Vitro Techniques; Male; Metoprolol; Myocardial Contraction; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Timolol | 1988 |
Adsorption of antihypertensives by suspensoids. Part 2. The adsorption of acebutolol, metoprolol, nadolol, oxprenolol, and timolol by attapulgite, charcoal, kaolin and magnesium trisilicate.
Topics: Acebutolol; Adsorption; Antihypertensive Agents; Charcoal; Kaolin; Magnesium; Magnesium Compounds; Magnesium Silicates; Metoprolol; Nadolol; Oxprenolol; Silicic Acid; Silicon; Silicon Compounds; Timolol | 1988 |
Adrenergic drugs and intraocular pressure: suppression of ocular hypertension induced by water loading.
Topics: Adrenergic beta-Antagonists; Animals; Butoxamine; Dobutamine; Ephedrine; Epinephrine; Intraocular Pressure; Isoproterenol; Male; Metoprolol; Propranolol; Pupil; Rabbits; Sympathomimetics; Terbutaline; Timolol; Water | 1980 |
Ocular penetration of beta-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Atenolol; Carbon Radioisotopes; Ciliary Body; Cornea; Eye; Female; Iris; Male; Metoprolol; Nictitating Membrane; Propranolol; Rabbits; Timolol; Tritium | 1980 |
New beta-adrenergic blockers.
Topics: Adrenergic beta-Antagonists; Aged; Humans; Metoprolol; Nadolol; Propanolamines; Timolol | 1980 |
Beta-blockers after myocardial infarction.
Topics: Adrenergic beta-Antagonists; Humans; Metoprolol; Myocardial Infarction; Propranolol; Timolol | 1982 |
Managing angina with beta blockers.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Humans; Metoprolol; Nadolol; Nitrates; Propanolamines; Propranolol; Timolol | 1982 |
Additive intraocular pressure reducing effect of topical timolol during systemic beta-blockade.
Topics: Administration, Oral; Administration, Topical; Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Blood Pressure; Female; Humans; Intraocular Pressure; Male; Metoprolol; Middle Aged; Propanolamines; Timolol | 1982 |
Secondary prevention after myocardial infarction.
Topics: Adrenergic beta-Antagonists; Coronary Disease; Humans; Metoprolol; Myocardial Infarction; Prognosis; Propranolol; Timolol | 1982 |
Central haemodynamic effects of beta blockers in hypertension. A comparison between atenolol, metoprolol, timolol, penbutolol, alprenolol pindolol and bunitrolol.
Topics: Adrenergic beta-Antagonists; Alprenolol; Atenolol; Hemodynamics; Humans; Hypertension; Metoprolol; Pindolol; Propanolamines; Time Factors; Timolol | 1983 |
Essential hypertension. The behaviour of the haemorheological determinants and their trends during beta-blocker treatment.
Topics: Adrenergic beta-Antagonists; Aged; Blood Proteins; Blood Viscosity; Female; Fibrinogen; Hematocrit; Humans; Hypertension; Male; Metoprolol; Middle Aged; Serum Albumin; Timolol | 1983 |
Beta-blockers in isoproterenol-enhanced essential tremor.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Humans; Isoproterenol; Metoprolol; Middle Aged; Propranolol; Timolol; Tremor | 1984 |
Beta-adrenergic antagonist inhibition of hepatic 3,5,3'-triiodothyronine production.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atenolol; Dithiothreitol; Liver; Male; Metoprolol; Nadolol; Pindolol; Propanolamines; Propranolol; Rats; Rats, Inbred Strains; Timolol; Triiodothyronine | 1984 |
Beta-adrenergic blockers. Choosing among them.
Topics: Adrenergic beta-Antagonists; Atenolol; Cardiovascular Diseases; Humans; Kinetics; Metoprolol; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol | 1984 |
Comparative effects of propranolol, timolol and metoprolol on myocardial infarct size after experimental coronary artery occlusion.
Topics: Animals; Blood Pressure; Coronary Circulation; Dogs; Fatty Acids, Nonesterified; Female; Heart Rate; Male; Metoprolol; Myocardial Infarction; Myocardium; Oxygen Consumption; Propranolol; Timolol | 1984 |
Effects of the (+/-)-, (+)- and (-)-forms of propranolol, timolol and metoprolol on noradrenergic transmission in the rat isolated right ventricle.
Topics: Animals; Drug Interactions; Electric Stimulation; Heart Ventricles; In Vitro Techniques; Isomerism; Male; Metoprolol; Myocardial Contraction; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Stimulation, Chemical; Timolol; Tritium | 1984 |
Gas chromatography with nitrogen-selective detection of metoprolol from human plasma after reaction with phosgene.
Topics: Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Metoprolol; Phosgene; Propanolamines; Timolol | 1983 |
Newer antihypertensive agents.
Topics: Aged; Antihypertensive Agents; Captopril; Diuretics; Humans; Hypertension; Male; Metoprolol; Middle Aged; Mineralocorticoid Receptor Antagonists; Pindolol; Saralasin; Timolol; United States; Vasoconstrictor Agents | 1980 |
[Comparative clinical study of metoprolol and timolol (author's transl)].
Topics: Glaucoma; Humans; Intraocular Pressure; Metoprolol; Propanolamines; Time Factors; Timolol; Vasoconstriction | 1981 |
[Drug therapy of angina pectoris. Are the possibilities exploited well enough?].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Angina, Unstable; Female; Humans; Isosorbide Dinitrate; Male; Metoprolol; Middle Aged; Propranolol; Retrospective Studies; Timolol | 1995 |
[Beta-receptor blockers after revascularization in coronary sclerosis].
Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Coronary Artery Bypass; Coronary Disease; Humans; Male; Metoprolol; Multicenter Studies as Topic; Myocardial Infarction; Propranolol; Recurrence; Time Factors; Timolol | 1995 |
Evaluation of the immobilized artificial membrane phosphatidylcholine. Drug discovery column for high-performance liquid chromatographic screening of drug-membrane interactions.
Topics: Acebutolol; Acetonitriles; Adrenergic beta-Antagonists; Alprenolol; Aniline Compounds; Atenolol; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Membranes, Artificial; Metoprolol; Models, Chemical; Osmolar Concentration; Oxprenolol; Phosphatidylcholines; Pindolol; Propranolol; Reproducibility of Results; Timolol | 1998 |
In vitro permeability of eight beta-blockers through Caco-2 monolayers utilizing liquid chromatography/electrospray ionization mass spectrometry.
Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Atenolol; Biological Availability; Caco-2 Cells; Cell Membrane Permeability; Chromatography, Liquid; Epithelial Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Mass Spectrometry; Metoprolol; Molecular Structure; Oxprenolol; Pindolol; Propranolol; Research Design; Timolol | 1998 |
Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose.
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Atenolol; Chlorthalidone; Confidence Intervals; Databases as Topic; Diuretics; Drug Compounding; Evaluation Studies as Topic; Female; Humans; Hydrochlorothiazide; Logistic Models; Male; Metolazone; Metoprolol; Myocardial Infarction; Odds Ratio; Ontario; Propranolol; Retrospective Studies; Sex Factors; Sodium Chloride Symporter Inhibitors; Timolol | 1999 |
Beta-adrenergic signalling and threshold adrenaline concentration for induction of fibrillation in the perfused heart pretreated with antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Cyclic AMP; Enalapril; Epinephrine; GTP-Binding Proteins; In Vitro Techniques; Male; Metoprolol; Perfusion; Potassium; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Signal Transduction; Timolol; Verapamil | 1999 |
Comparison of the neuroprotective effects of adrenoceptor drugs in retinal cell culture and intact retina.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Brimonidine Tartrate; Calcium; Cell Culture Techniques; Cell Survival; Dose-Response Relationship, Drug; Fura-2; Glutamic Acid; Metoprolol; N-Methylaspartate; Neuroglia; Neuroprotective Agents; Quinoxalines; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Timolol | 2002 |
Polymeric matrix membrane sensors for sensitive potentiometric determination of some beta-blockers in pharmaceutical preparations.
Topics: Adrenergic beta-Antagonists; Atenolol; Bisoprolol; Indicators and Reagents; Ions; Metoprolol; Phosphates; Polyvinyl Chloride; Potentiometry; Propranolol; Sensitivity and Specificity; Timolol; Tungsten Compounds | 2003 |
Iontophoretic in vivo transdermal delivery of beta-blockers in hairless rats and reduced skin irritation by liposomal formulation.
Topics: Administration, Cutaneous; Adrenergic beta-Antagonists; Animals; Biological Transport; Chromatography, High Pressure Liquid; Drug Carriers; Injections, Intravenous; Iontophoresis; Irritants; Liposomes; Metoprolol; Oxprenolol; Propranolol; Rats; Skin; Skin Absorption; Sotalol; Stereoisomerism; Timolol | 2003 |
Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: assessment of nonlinearity of metoprolol, timolol, and propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; Blood Proteins; Drug Design; Female; Male; Metabolic Clearance Rate; Metoprolol; Microsomes, Liver; Nonlinear Dynamics; Predictive Value of Tests; Propranolol; Rats; Rats, Wistar; Substrate Specificity; Timolol | 2005 |
Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Algorithms; Animals; Blood Proteins; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Male; Metoprolol; Models, Biological; Propranolol; Protein Binding; Rats; Rats, Inbred WKY; Receptors, Adrenergic, beta; Timolol | 2009 |