Page last updated: 2024-08-16

timolol and indomethacin

timolol has been researched along with indomethacin in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (22.50)	18.7374
1990's	8 (20.00)	18.2507
2000's	12 (30.00)	29.6817
2010's	11 (27.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Hwang, KK; Mandagere, AK; Thompson, TN	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Caron, G; Ermondi, G	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bhandare, P; Dhume, V; Diniz-D'Souza, R; Mainker, A	1
Höh, H	1
Jones, TR; Masson, P	2
Briones, O; Dawson, CR; Santos, C	1
de Jong, PT; Leys, MJ; Pameijer, JH	1
Abrams, SM; Mekki, QA; Petounis, AD; Turner, P	1
Clark, L; Cohen, MM; Feldman, F; Goldberg, HS	1
Gherezghiher, T; Koss, M; March, WF; Nordquist, R	1
Clark, L; Cohen, MM; Feldman, F; Lichter, M	1
Haddeman, E; Hoyng, PF; van Alphen, GW	1
Kitamura, Y; Okamura, T; Toda, N	1
Okamura, T; Toda, N; Yoshida, K	1
Kaehler, C; Kieselbach, G; Saria, A; Troger, J	2
Peng, DW	1
Chen, B; Justin, R	1

Reviews

1 review(s) available for timolol and indomethacin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

4 trial(s) available for timolol and indomethacin

Article	Year
[Local anesthetic effect and subjective tolerance of 0.5% levobunolol in normal eyes]. Klinische Monatsblatter fur Augenheilkunde, 1990, Volume: 197, Issue:1 Topics: Adolescent; Adult; Anesthetics, Local; Betaxolol; Cornea; Double-Blind Method; Humans; Indomethacin; Levobunolol; Middle Aged; Nociceptors; Ophthalmic Solutions; Pain Measurement; Propoxycaine; Prospective Studies; Randomized Controlled Trials as Topic; Sensory Thresholds; Timolol	1990
Indomethacin does not attenuate the ocular hypotensive effect of timolol. British journal of clinical pharmacology, 1985, Volume: 19, Issue:4 Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Female; Humans; Indomethacin; Intraocular Pressure; Male; Timolol	1985
Effect of topical indomethacin and timolol maleate on intraocular pressure in normal subjects. American journal of ophthalmology, 1985, May-15, Volume: 99, Issue:5 Topics: Double-Blind Method; Humans; Indomethacin; Intraocular Pressure; Random Allocation; Timolol	1985
[Prevention of IOP rise following laser iridectomy with topical timolol and indomethacin]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1993, Volume: 29, Issue:2 Topics: Female; Glaucoma, Angle-Closure; Humans; Indomethacin; Iris; Laser Therapy; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Postoperative Complications; Premedication; Prospective Studies; Timolol	1993

Other Studies

35 other study(ies) available for timolol and indomethacin

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates. Journal of medicinal chemistry, 2002, Jan-17, Volume: 45, Issue:2 Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Inactivation, Metabolic; Liver; Microsomes, Liver; Models, Biological; Permeability; Pharmacokinetics; Rats; Species Specificity	2002
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Protective effect of propranolol on ethanol-induced gastric lesions in mice. European journal of pharmacology, 1990, Nov-27, Volume: 191, Issue:2 Topics: Administration, Oral; Animals; Ethanol; Gastrointestinal Hemorrhage; Indomethacin; Injections, Intraperitoneal; Male; Mice; Premedication; Propranolol; Stomach Ulcer; Timolol	1990
Effects of timolol, indomethacin, and MK-571 on bronchoconstriction to infused leukotriene D4 in guinea pigs. Canadian journal of physiology and pharmacology, 1990, Volume: 68, Issue:7 Topics: Aerosols; Anesthesia; Animals; Bronchi; Constriction, Pathologic; Guinea Pigs; Indomethacin; Infusions, Intravenous; Male; Propionates; Quinolines; SRS-A; Timolol	1990
Peripheral adrenergic stimulation and indomethacin in experimental ocular shedding of HSV. Current eye research, 1987, Volume: 6, Issue:1 Topics: Animals; Eye; Hydroxydopamines; Indomethacin; Keratitis, Dendritic; Oxidopamine; Rabbits; Simplexvirus; Stimulation, Chemical; Sympathomimetics; Timolol	1987
Intermediate-term changes in intraocular pressure after neodymium-YAG laser posterior capsulotomy. American journal of ophthalmology, 1985, Aug-15, Volume: 100, Issue:2 Topics: Humans; Indomethacin; Intraocular Pressure; Lasers; Lens Capsule, Crystalline; Lens, Crystalline; Ophthalmic Solutions; Timolol	1985
Comparative study of the pulmonary effects of intravenous leukotrienes and other bronchoconstrictors in anaesthetized guinea pigs. Prostaglandins, 1985, Volume: 29, Issue:5 Topics: Airway Resistance; Anesthesia; Animals; Arachidonic Acid; Arachidonic Acids; Atropine; Blood Pressure; Bronchi; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Hexamethonium Compounds; Histamine; Indomethacin; Lung; Male; Methysergide; Prostaglandin Endoperoxides, Synthetic; Pyrilamine; SRS-A; Timolol; Vagotomy	1985
Ultrastructural and pharmacologic studies on laser-induced glaucoma in primates and rabbits. Lasers in surgery and medicine, 1984, Volume: 4, Issue:4 Topics: Animals; Disease Models, Animal; Epinephrine; Glaucoma; Indomethacin; Intraocular Pressure; Lasers; Macaca mulatta; Male; Rabbits; Time Factors; Timolol; Trabecular Meshwork	1984
Effect of indomethacin on the ocular hypotensive action of timolol maleate. American journal of ophthalmology, 1984, Jul-15, Volume: 98, Issue:1 Topics: Double-Blind Method; Humans; Indomethacin; Intraocular Pressure; Ophthalmic Solutions; Random Allocation; Timolol	1984
Does prostacyclin mediate alpha-adrenergic induced hypotension? Documenta ophthalmologica. Advances in ophthalmology, 1982, Sep-30, Volume: 53, Issue:2 Topics: Animals; Aqueous Humor; Epinephrine; Epoprostenol; Indomethacin; Intraocular Pressure; Iris; Isoproterenol; Norepinephrine; Phenoxybenzamine; Rabbits; Timolol; Tranylcypromine	1982
Role of nitroxidergic nerve in dog retinal arterioles in vivo and arteries in vitro. The American journal of physiology, 1994, Volume: 266, Issue:5 Pt 2 Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arterioles; Atropine; Dogs; Electric Stimulation; Endothelium, Vascular; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroglycerin; Papaverine; Retinal Vessels; Tetrodotoxin; Timolol	1994
Involvement of nitroxidergic and noradrenergic nerves in the relaxation of dog and monkey temporal veins. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:5 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amino Acid Oxidoreductases; Animals; Arginine; Atropine; Dinoprost; Dogs; Electric Stimulation; Female; Hexamethonium; Indomethacin; Macaca; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH Dehydrogenase; Nerve Fibers; Nicotine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Prazosin; Tetrodotoxin; Timolol; Veins	1995
Indomethacin reduces substance P levels in human ocular aqueous humor. European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1 Topics: Adult; Aged; Aqueous Humor; Female; Gentamicins; Humans; Indomethacin; Male; Middle Aged; Radioimmunoassay; Substance P; Timolol	1993
Topical indomethacin decreases substance P immunoreactivity in human ocular aqueous humor. Regulatory peptides, 1993, Jul-02, Volume: 46, Issue:1-2 Topics: Administration, Topical; Analysis of Variance; Aqueous Humor; Cataract Extraction; Humans; Indomethacin; Radioimmunoassay; Substance P; Timolol	1993
Characterisation and drug release performance of biodegradable chitosan-graphene oxide nanocomposites. Carbohydrate polymers, 2014, Mar-15, Volume: 103 Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chitosan; Cisplatin; Drug Delivery Systems; Graphite; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Indomethacin; Nanocomposites; Oxides; Propranolol; Surface Properties; Timolol	2014