timolol has been researched along with eye in 141 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (34.75) | 18.7374 |
| 1990's | 39 (27.66) | 18.2507 |
| 2000's | 28 (19.86) | 29.6817 |
| 2010's | 24 (17.02) | 24.3611 |
| 2020's | 1 (0.71) | 2.80 |
| Authors | Studies |
|---|---|
| Le Douarec, JC; Lotti, VJ; Schmitt, C; Vareilles, P | 1 |
| D'Anna, SA; Koslov, S; Kues, HA; Lutty, GA; McLeod, DS; Monahan, JC | 1 |
| Lee, VH; Ohdo, S; Zhu, J | 1 |
| Järvinen, K; Urtti, A | 1 |
| Baba, H; Tokoro, T; Yamazaki, S | 1 |
| Kitada, S; Lee, DA; Nguyen, KD; Shapourifar-Tehrani, S; Williams, DE | 1 |
| Lee, VH; Moy, KC; Podder, SK | 1 |
| Bloedow, DC; Ellis, PP; Pfoff, DS; Riegel, MR; Wu, PY | 1 |
| Cruess, DF; Kao, SF; Kincaid, MC; Rabbani, R; Skuta, GL; Smith, DL | 1 |
| Smith, SE; Trew, DR | 1 |
| Lee, VH; Luo, AM; Sasaki, H | 1 |
| Chiou, GC; Li, BH; Shen, ZF; Zhao, F | 1 |
| Haruta, Y; Hill, JM; Kaufman, HE; Reidy, JJ; Rootman, DS | 1 |
| Chiou, FY; Chiou, GC; Li, BH; Ruiz-Razura, A | 1 |
| Bartels, SP; Belmonte, C; Liu, JH; Neufeld, AH | 1 |
| Fredj, D; Lapalus, P; Moulin, G | 1 |
| Chen, J; Dowling, MC; Feldmann, BJ; Woodward, DF | 1 |
| Hesse, R; Kendall, K; Lavin, P; Mundorf, T; Nardin, G; Zimmerman, TJ | 1 |
| Bundgaard, H; Lee, VH; Potter, DE; Shumate, DJ | 1 |
| Briones, O; Dawson, CR; Santos, C | 1 |
| Araullo-Cruz, T; Gordon, YJ; Harwick, J; Romanowski, E | 1 |
| Berman, E; Dudley, JB; Haruta, Y; Hill, JM; Kwon, BS; Maguire, LJ; Shimomura, Y | 1 |
| Aula, P; Huupponen, R; Kaila, T; Salminen, L | 1 |
| Fukado, Y; Inatomi, M; Koide, R; Maeda, I; Oguchi, K; Uchida, E; Ueda, T; Yasuhara, H | 1 |
| Pipkin, JD; Repta, AJ; Rork, G; Sendo, T; Urtti, A | 1 |
| Huupponen, R; Kaila, T; Salminen, L | 1 |
| Green, K; Hatchett, TL | 1 |
| Shin, DH | 1 |
| Chiou, GC; Yan, HY | 1 |
| Bullimore, MA; Gilmartin, B | 1 |
| Albert, J; Davidson, J; Putterman, GJ | 1 |
| Caruso, C; Cennamo, G; Nastri, G | 1 |
| Trawick, AB | 1 |
| Kodama, T | 1 |
| Green, K; Schermerhorn, J | 1 |
| Chiou, GC; Lauber, JK; McLaughlin, MA | 1 |
| Innemee, HC; Ros, FE; van Zwieten, PA | 1 |
| Bartels, SP; Jumblatt, MM; Neufeld, AH; Roth, HO | 1 |
| Colasanti, BK; Trotter, RR | 1 |
| Bengtsson, E; Holmdahl, G | 1 |
| Avaux, G; Missotten, L; Van Tornout, I; Van Wijnendaele, J | 1 |
| Araie, M; Ishii, Y; Kitagawa, M; Sakai, Y; Takase, M; Yokoyama, Y | 1 |
| Chou, A; Go, F; Hori, S; Komatsu, M; Takase, M | 1 |
| Kaufman, HE; Leader, B; Zimmerman, TJ | 1 |
| Folberg, R; Hargett, NA; McLean, IW; Weaver, JE | 1 |
| Petursson, GJ; Shock, JP; Stone, JE; Zalta, AH | 1 |
| Doyle, WJ; Meeks, RH; Weber, PA | 1 |
| Aziz, MZ; Green, K; Jay, WM | 1 |
| Bartels, SP; Liu, JH; Neufeld, AH | 1 |
| Kramer, P; Ritch, R | 1 |
| Baumann, JD; Hetherington, J; Zimmerman, TJ | 1 |
| Fraunfelder, FT; Meyer, SM | 1 |
| Salminen, L; Urtti, A | 1 |
| Gilmartin, B; Hogan, RE; Thompson, SM | 1 |
| Keates, EU; Stone, R | 1 |
| Anderson, J; Blumenthal, M; Chen, CC; Duzman, E; Twizer, H | 1 |
| Babický, A; Obenberger, J; Růzicková, E; Výborný, P | 1 |
| Araie, M; Kitagawa, M; Takase, M; Yokoyama, Y | 1 |
| Blanchet, LM; Coupland, SG; Kirkham, TH; Nelson, DE | 1 |
| LeDouarec, JC; Lotti, VJ; Schmitt, CJ | 1 |
| Bosem, ME; Lusky, M; Morsman, CD; Weinreb, RN | 1 |
| Cunliffe, I; McIntyre, C; Rees, R; Rennie, I | 1 |
| Kaila, T; Vuori, ML | 1 |
| Kaila, T; Rouhiainen, H; Saano, V; Urtti, A | 1 |
| Becker, MA; Liu, GS; Menon, IA; Persad, SD; Thibodeau, JR; Trope, GE | 1 |
| Kompella, UB; Lee, VH; Lee, YH | 1 |
| Chetoni, P; Lee, VH; Li, SY; Saettone, MF; Sasaki, H | 1 |
| Urtti, A | 1 |
| Freedman, NJ; Freedman, SF; Keates, EU; Lobaugh, B; Ollie, A; Samsa, GP; Shields, MB | 1 |
| Claridge, KG | 1 |
| Crandall, AS; Mamalis, N; Sharir, M; Zimmerman, TJ | 1 |
| Carr, RD; Humphries, RG; Millar, JC; Wilson, WS | 1 |
| Acheampong, AA; Breau, A; Lam, S; Luo, W; Shackleton, M; Tang-Liu, DD | 1 |
| Chen, IJ; Chiou, GC; Hong, SJ; Liu, SX; Sheu, MM; Wu, BN | 1 |
| Cheng, YL; Friedrich, SW; Rootman, DS; Saville, BA | 1 |
| Hong, SJ; Wang, HZ; Wu, KY | 1 |
| Chetoni, P; Perini, G; Saettone, MF; Vigetti, B | 1 |
| Ichikawa, M; Kawakami, S; Mukai, T; Nakamura, J; Nishida, K; Sasaki, H; Yamamura, K | 1 |
| Crichton, AC; Drance, SM; Greve, EL; Hoyng, PF; Mills, RP; Rulo, AH | 1 |
| Huang, JK; Hung, PT; Shih, YF; Wang, TH | 1 |
| Abiko, T; Ishiko, S; Kato, Y; Kitaya, N; Mori, F; Nagaoka, T; Ogasawara, H; Yoshida, A | 1 |
| Barros, MD; Bodor, N; Farag, HH; Prokai, L; Somogyi, G; Wu, WM | 1 |
| Berrino, L; Boldrini, E; Imperatore, A; Lampa, E; Matera, MG; Rossi, F; Russo, F | 1 |
| Jaitely, V; Mysore, N; Venkatesan, N; Vyas, SP | 1 |
| Ichikawa, M; Mukai, T; Nakamura, J; Nakashima, M; Nishida, K; Sasaki, H; Yamamura, K | 1 |
| Cantor, LB; Evans, DW; Harris, A | 1 |
| Järvinen, K; Paronen, P; Sääskilahti, M; Svarfvar, B; Tarvainen, T; Urtii, A | 1 |
| Becker, R; Pillunat, LE; Schmidt, KG; von Rückmann, A | 1 |
| Cole, C; Garzozi, H; Harris, A; Jonescu-Cuypers, CP; Kagemann, L; Martin, B; Nowacki, EA | 1 |
| Ishibashi, Y; Muto, T; Roy, S; Sato, T | 1 |
| Mao, J; Sui, R; Zhao, J | 1 |
| Izumi, H; Karita, K; Naito, A; Tamai, M | 1 |
| Archibald, ML; Chauhan, BC; Kelly, ME; LeVatte, TL; Tan, AY; Tremblay, F | 1 |
| Calissendorff, B; Grunge-Lowerud, A; Högberg, G; Sjöquist, B | 1 |
| Gressnerová, S; Oláh, Z; Veselá, A; Veselovský, J | 1 |
| Kaila, T; Korte, JM; Saari, KM | 1 |
| Bucci, MG; Centofanti, M; Gregori, D; Manni, G; Migliardj, R; Oddone, F; Scipioni, M | 1 |
| Recker, K | 1 |
| Brignoli, R; Mermoud, A; Ravinet, E | 1 |
| Agarwal, HC; Gupta, V; Sihota, R | 1 |
| Ishibashi, T; Kinoshita, S; Yokoi, N | 1 |
| Harris, A; Janulevicienë, I; Kagemann, L; McCranor, L; Siesky, B | 1 |
| Criado, S; García, NA | 1 |
| Aggarwal, D; Kaur, IP | 1 |
| Aggermann, T; Buehl, W; Eichler, HG; Fuchsjäger-Mayrl, G; Kolodjaschna, J; Polska, E; Rainer, G; Schmetterer, L; Vass, C; Wally, B; Weigert, G | 1 |
| Chauhan, A; Zhu, H | 1 |
| Martínez, A; Sánchez, M | 1 |
| Hardarson, SH; Loftsson, T; Níelsdóttir, GE; Sigurdsson, HH; Stefánsson, E; Valgeirsson, J | 1 |
| Harris, A; Malinovsky, VE; McCranor, L; Rechtman, E; Siesky, B; Sines, D; Yung, CW; Zalish, M | 1 |
| Li, R; Liu, JH; Nelson, TR; Weinreb, RN | 1 |
| Ammon, DM; Borazjani, RN; Foster, WJ; Garcia, CA; Hacker, MC; Haesslein, A; Kunzler, JF; Mikos, AG; Salamone, JC; Ueda, H | 1 |
| Higuchi, S; Kawazu, K; Kitahara, T; Nakamura, J; Nakashima, M; Nishida, K; Sakanaka, K; Sasaki, H; Tomonari, M | 1 |
| Czechowicz-Janicka, K; Kałuzny, BJ; Kałuzny, J; Kecik, D; Sobecki, R; Stewart, JA; Stewart, WC | 1 |
| Ajayi, BG; Ashaye, AO; Fasina, O | 1 |
| Ammon, DM; Borazjani, RN; Hacker, MC; Haesslein, A; Kunzler, JF; Mikos, AG; Salamone, JC; Ueda, H | 1 |
| Konstas, AG; Kozobolis, VP; Lasaridis, AN; Mikropoulos, D; Nelson, LA; Pikilidou, MI; Sarafidis, PA; Stewart, WC; Tsironi, S | 1 |
| Bwatwa, J; Ehrlich, R; Harris, A; Kagemann, L; McCranor, L; Miller, B; Regev, G; Siesky, B; Stefansson, E | 1 |
| García-Pérez, JL; González-Gordaliza, C; Muñoz-Negrete, FJ; Puerto-Hernández, B; Rebolleda Fernández, G | 1 |
| Bastien, NR; Behki, R; Boucher, S; Crichton, AC; Harasymowycz, P; Hutnik, CM; Ibrahim, F; Liao, C; Rifkind, AW; Sampalis, JS; Solomon, L | 1 |
| Daito, M; Hiraoka, T; Kiuchi, T; Okamoto, F; Oshika, T | 1 |
| Hakkola, J; Mäenpää, J; Pelkonen, O; Vapaatalo, H; Volotinen, M | 1 |
| Cai, SP; Liu, G; Liu, X; Pang, IH; Wang, H; Yan, N; Yu, W; Zeng, T | 1 |
| Abrams, L; Cantor, L; Ehrlich, R; Harris, A; Hollander, DA; Rusia, D; Shoja, MM; Shoshani, Y; Siesky, B; Williams, JM | 1 |
| Cunha-Júnior, Ada S; Faraco, AG; Fulgêncio, Gde O; Ribeiro, RR; Viana, FA; Yoshida, MI | 1 |
| Ohguro, H; Ohguro, I | 1 |
| Burke, MT; Carbia, BE; Chauhan, A; Peng, CC; Plummer, C | 1 |
| Garhöfer, G; Hommer, A; Popa-Cherecheanu, A; Qiao, C; Resch, H; Schmetterer, L; Sperl, P | 1 |
| Feke, GT; Pasquale, LR; Rhee, DJ; Turalba, AV | 1 |
| Barros, Jde N; Faria, NV; Gomes, JÁ; Mello, PA; Montiani-Ferreira, F; Nogueira-Filho, PA; Russ, HH | 1 |
| Carmichael, TR; Choonara, YE; du Toit, LC; Kumar, P; Moosa, RM; Pillay, V; Tomar, LK; Tyagi, C | 1 |
| Backman, JT; Kautiainen, H; Mäenpää, J; Neuvonen, M; Neuvonen, PJ; Niemi, M; Volotinen-Maja, M | 1 |
| Fukuda, M; Sasaki, H | 1 |
| Bikiaris, DN; Karavas, E; Kostoglou, M; Koukaras, EN; Koutris, E; Siafaka, PI; Titopoulou, A | 1 |
| Ha, SJ; Seo, du R | 1 |
| Antopolsky, M; Hagström, M; Kidron, H; Latonen, S; Manzanares, JA; Rimpelä, AK; Schmitt, M; Urtti, A | 1 |
| Aslan, CA; Baltepe Altıok, I; Eliacik, M; Gulkilik, G; Karaman Erdur, S; Kaya, F | 1 |
| Cong, X; Molloy, BL; Watson, C | 1 |
| Allemandi, DA; Arias, FJ; Fernández-Colino, A; Girotti, A; Palma, SD; Quinteros, DA | 1 |
| Ma, F; Ma, H; Ma, J; Shang, Q; Su, J; Wang, X; Yu, J; Zhang, T | 1 |
| Desai, AR; Maulvi, FA; Patil, RJ; Ranch, KM; Shah, DO; Shah, SA; Shukla, MR; Vaidya, RJ; Vyas, BA | 1 |
| Babiskin, A; Chen, Z; Fan, J; German, C; Przekwas, A; Tan, ML; Walenga, R; Zhao, L | 1 |
5 review(s) available for timolol and eye
| Article | Year |
|---|---|
Advances in ocular pharmacology.
Topics: Animals; Cannabis; Carbachol; Cytochalasin B; Epinephrine; Eye; Eye Diseases; Glaucoma; Humans; Idoxuridine; Interferons; Intraocular Pressure; Keratitis; Membranes, Artificial; Pharmaceutical Preparations; Timolol; Trifluridine; Vidarabine; Virus Diseases | 1980 |
Delivery of antiglaucoma drugs: ocular vs systemic absorption.
Topics: Absorption; Animals; Biological Availability; Delayed-Action Preparations; Drug Delivery Systems; Eye; Glaucoma; Half-Life; Humans; Ophthalmic Solutions; Timolol | 1994 |
Reduced intraocular pressure and increased ocular perfusion pressure in normal tension glaucoma: a review of short-term studies with three dose regimens of latanoprost treatment.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Circadian Rhythm; Dose-Response Relationship, Drug; Eye; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Timolol | 1997 |
Four years later: a clinical update on latanoprost.
Topics: Antihypertensive Agents; Aqueous Humor; Blood Flow Velocity; Circadian Rhythm; Clinical Trials as Topic; Drug Therapy, Combination; Eye; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ocular Hypertension; Prostaglandins F, Synthetic; Safety; Sulfonamides; Thiophenes; Timolol | 2003 |
Metabolism of ophthalmic timolol: new aspects of an old drug.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Eye; Glaucoma; Heart Rate; Humans; Intraocular Pressure; Liver; Timolol | 2011 |
28 trial(s) available for timolol and eye
| Article | Year |
|---|---|
Effects of eyelid closure and nasolacrimal duct occlusion on the systemic absorption of ocular timolol in human subjects.
Topics: Absorption; Administration, Topical; Adult; Eye; Eyelids; Female; Humans; Male; Nasolacrimal Duct; Timolol | 1986 |
Tonic accommodation, cognitive demand, and ciliary muscle innervation.
Topics: Accommodation, Ocular; Adult; Cognition; Eye; Humans; Male; Muscles; Optometry; Sympathetic Nervous System; Timolol | 1987 |
Effect of topical timolol maleate on exercise performance.
Topics: Administration, Topical; Adult; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Eye; Female; Heart Rate; Humans; Male; Physical Exertion; Placebos; Random Allocation; Respiration; Timolol | 1984 |
The effect of Timolol Maleate on tonic accommodation, tonic vergence, and pupil diameter.
Topics: Accommodation, Ocular; Eye; Eye Movements; Fixation, Ocular; Humans; Sympathetic Nervous System; Timolol | 1984 |
Diacetyl derivative of nadolol. I. Ocular pharmacology and short-term ocular hypotensive effect in glaucomatous eyes.
Topics: Absorption; Adult; Animals; Clinical Trials as Topic; Double-Blind Method; Eye; Female; Glaucoma, Open-Angle; Humans; Hydrolysis; Male; Nadolol; Ocular Hypertension; Propanolamines; Rabbits; Timolol | 1982 |
The effect of topical beta-adrenoceptor blocking agents on pulsatile ocular blood flow.
Topics: Adrenergic beta-Antagonists; Betaxolol; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Levobunolol; Male; Middle Aged; Ocular Hypertension; Pulsatile Flow; Time Factors; Timolol | 1995 |
Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level.
Topics: Administration, Topical; Adult; Carteolol; Cholesterol; Cholesterol, HDL; Double-Blind Method; Eye; Humans; Intraocular Pressure; Lipids; Male; Middle Aged; Ophthalmic Solutions; Prospective Studies; Timolol | 1993 |
A comparison of the ocular tolerability of a single dose of timolol and levobunolol in healthy normotensive volunteers.
Topics: Adult; Aged; Asthenopia; Double-Blind Method; Drug Tolerance; Eye; Female; Humans; Intraocular Pressure; Levobunolol; Male; Middle Aged; Timolol; Vision Disorders | 1993 |
The effect of 0.5% timolol maleate on the ocular perfusion of ocular hypertensive patients by scanning laser flowmetry.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Blood Volume; Eye; Female; Humans; Male; Ocular Hypertension; Regional Blood Flow; Timolol | 1997 |
Effect of timolol and UF-021 (a prostaglandin-related compound) on pulsatile ocular blood flow in normal volunteers.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Adult; Blood Pressure; Dinoprost; Double-Blind Method; Eye; Heart Rate; Humans; Intraocular Pressure; Ophthalmic Solutions; Pulsatile Flow; Reference Values; Reproducibility of Results; Timolol | 1997 |
Primary open-angle glaucoma patients characterized by ocular vasospasm demonstrate a different ocular vascular response to timolol versus betaxolol.
Topics: Adrenergic beta-Antagonists; Betaxolol; Cross-Over Studies; Double-Blind Method; Eye; Female; Glaucoma, Open-Angle; Hemodynamics; Humans; Hypercapnia; Intraocular Pressure; Male; Middle Aged; Ophthalmic Artery; Spasm; Timolol; Ultrasonography, Doppler, Color; Vascular Resistance | 1999 |
[Ocular pulse amplitude, intraocular pressure and beta blocker/carbonic anhydrase inhibition in combined therapy of primary open-angle glaucoma].
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Pulsatile Flow; Sulfonamides; Thiophenes; Timolol | 1999 |
Effect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucoma.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Flow Velocity; Ciliary Arteries; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Eye; Fluorescein Angiography; Glaucoma, Open-Angle; Humans; Indocyanine Green; Intraocular Pressure; Laser-Doppler Flowmetry; Ophthalmic Artery; Ophthalmic Solutions; Ophthalmoscopy; Regional Blood Flow; Retinal Artery; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Ultrasonography; Visual Acuity | 2001 |
Systemic bioavailability and cardiopulmonary effects of 0.5% timolol eyedrops.
Topics: Absorption; Adrenergic beta-Antagonists; Adult; Area Under Curve; Biological Availability; Blood Pressure; Cross-Over Studies; Eye; Female; Forced Expiratory Volume; Heart Rate; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Timolol; Vital Capacity | 2002 |
Effect of changing from concomitant timolol pilocarpine to bimatoprost monotherapy on ocular blood flow and IOP in primary chronic angle closure glaucoma.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Aged; Amides; Bimatoprost; Chronic Disease; Cloprostenol; Drug Therapy, Combination; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Lipids; Male; Middle Aged; Pilocarpine; Prospective Studies; Pulsatile Flow; Regional Blood Flow; Single-Blind Method; Timolol; Treatment Outcome | 2003 |
A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients.
Topics: Adult; Aged; Antihypertensive Agents; Blood Flow Velocity; Cross-Over Studies; Drug Therapy, Combination; Eye; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Middle Aged; Prostaglandins F, Synthetic; Pulsatile Flow; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Ultrasonography, Doppler | 2004 |
Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension.
Topics: Aged; Antihypertensive Agents; Choroid; Double-Blind Method; Eye; Female; Glaucoma, Open-Angle; Heart Rate; Hemodynamics; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Middle Aged; Ocular Hypertension; Optic Disk; Regional Blood Flow; Regression Analysis; Retinal Vessels; Sulfonamides; Thiophenes; Timolol | 2005 |
A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Middle Aged; Prostaglandins F, Synthetic; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2006 |
A comparative analysis of the effects of the fixed combination of timolol and dorzolamide versus latanoprost plus timolol on ocular hemodynamics and visual function in patients with primary open-angle glaucoma.
Topics: Adrenergic beta-Antagonists; Aged; Blood Pressure; Cross-Over Studies; Double-Blind Method; Eye; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol; Visual Acuity | 2006 |
Efficacy and safety of latanoprost versus pilocarpine/timolol maleate fixed combination in patients with primary open-angle glaucoma or ocular hypertension.
Topics: Aged; Drug Administration Schedule; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Pain; Pilocarpine; Prostaglandins F, Synthetic; Timolol; Treatment Outcome; Vision Disorders | 2008 |
24-hour intraocular pressure and blood pressure levels with latanoprost/timolol fixed combination versus timolol.
Topics: Aged; Blood Pressure; Circadian Rhythm; Cross-Over Studies; Drug Administration Schedule; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prostaglandins F, Synthetic; Timolol | 2009 |
Ocular blood flow and oxygen delivery to the retina in primary open-angle glaucoma patients: the addition of dorzolamide to timolol monotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Eye; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Middle Aged; Oximetry; Oxygen; Regional Blood Flow; Retina; Retinal Vessels; Sulfonamides; Thiophenes; Timolol; Ultrasonography, Doppler, Color | 2010 |
[Evaluation of the effect of bimatoprost/timolol fixed combination on ocular blood flow in patients with ocular hypertension using colour Doppler imaging. Preliminary study].
Topics: Amides; Antihypertensive Agents; Bimatoprost; Cloprostenol; Double-Blind Method; Drug Combinations; Eye; Female; Humans; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Regional Blood Flow; Timolol; Ultrasonography, Doppler, Color | 2010 |
Short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and blood flow in glaucoma.
Topics: Administration, Ophthalmic; Aged; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Male; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2012 |
A double-masked randomized crossover study comparing the effect of latanoprost/timolol and brimonidine/timolol fixed combination on intraocular pressure and ocular blood flow in patients with primary open-angle glaucoma or ocular hypertension.
Topics: Aged; Antihypertensive Agents; Blood Flow Velocity; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Time Factors; Timolol; Ultrasonography, Doppler, Color | 2012 |
Effects of dorzolamide-timolol and brimonidine-timolol on retinal vascular autoregulation and ocular perfusion pressure in primary open angle glaucoma.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Homeostasis; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Quinoxalines; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol | 2013 |
Ocular surface evaluation in patients treated with a fixed combination of prostaglandin analogues with 0.5% timolol maleate topical monotherapy: a randomized clinical trial.
Topics: Aged; Amides; Antihypertensive Agents; Bimatoprost; Cloprostenol; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; HLA-DR Antigens; Humans; Immunohistochemistry; Interleukin-6; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Prostaglandins F, Synthetic; Prostaglandins, Synthetic; Single-Blind Method; Timolol; Travoprost; Treatment Outcome | 2013 |
Preventive Dorzolamide-Timolol for Rising Intraocular Pressure During Steep Trendelenburg Position Surgery.
Topics: Adult; Aged; Blood Pressure; Double-Blind Method; Drug Combinations; Eye; Female; Head-Down Tilt; Humans; Intraocular Pressure; Intraoperative Complications; Laparoscopy; Male; Middle Aged; Monitoring, Intraoperative; Ocular Hypertension; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2016 |
108 other study(ies) available for timolol and eye
| Article | Year |
|---|---|
[Experimental studies with timolol: a new ocular hypotensive agent (author's transl)].
Topics: Animals; Aqueous Humor; Eye; Intraocular Pressure; Propanolamines; Rabbits; Timolol | 1978 |
Increased sensitivity of the non-human primate eye to microwave radiation following ophthalmic drug pretreatment.
Topics: Administration, Topical; Animals; Capillary Permeability; Endothelium, Corneal; Eye; Fluorescein Angiography; Iris; Macaca fascicularis; Macaca mulatta; Microwaves; Pilocarpine; Timolol | 1992 |
Light-dark variations in ocular timolol concentrations following topical solution instillation in the pigmented rabbit.
Topics: Absorption; Animals; Anterior Eye Segment; Chromatography, High Pressure Liquid; Conjunctiva; Dark Adaptation; Eye; Light; Male; Ophthalmic Solutions; Pigmentation; Rabbits; Sclera; Timolol; Uvea | 1992 |
Duration and long-term efficacy of phenylephrine-induced reduction in the systemic absorption of ophthalmic timolol in rabbits.
Topics: Absorption; Animals; Conjunctiva; Eye; Female; Longitudinal Studies; Male; Nasal Mucosa; Ophthalmic Solutions; Phenylephrine; Rabbits; Timolol; Vasoconstriction | 1992 |
[Effects of timolol and carteolol on ocular pulsatile blood flow].
Topics: Adult; Carteolol; Eye; Humans; Intraocular Pressure; Pulsatile Flow; Regional Blood Flow; Timolol | 1992 |
Effects of timolol, betaxolol, and levobunolol on human tenon's fibroblasts in tissue culture.
Topics: Benzalkonium Compounds; Betaxolol; Cell Adhesion; Cell Division; Cells, Cultured; DNA Replication; Eye; Fascia; Fibroblasts; Humans; Levobunolol; Timolol | 1992 |
Improving the safety of topically applied timolol in the pigmented rabbit through manipulation of formulation composition.
Topics: Administration, Topical; Animals; Chromatography, High Pressure Liquid; Drug Delivery Systems; Eye; Hydrogen-Ion Concentration; Male; Polymers; Rabbits; Timolol | 1992 |
Effect of nasolacrimal occlusion on timolol concentrations in the aqueous humor of the human eye.
Topics: Aged; Aged, 80 and over; Aqueous Humor; Cataract Extraction; Eye; Female; Humans; Male; Middle Aged; Nasolacrimal Duct; Timolol | 1992 |
The effects of glaucoma medications on Tenon's capsule and conjunctiva in the rabbit.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Conjunctiva; Disease Models, Animal; Epinephrine; Eye; Fascia; Glaucoma; Pilocarpine; Pilot Projects; Rabbits; Timolol | 1991 |
Postural studies in pulsatile ocular blood flow: II. Chronic open angle glaucoma.
Topics: Adult; Aged; Blood Pressure; Chronic Disease; Eye; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Posture; Pulsatile Flow; Supination; Time Factors; Timolol | 1991 |
Ocular drug interactions involving topically applied timolol in the pigmented rabbit.
Topics: Absorption; Animals; Drug Interactions; Epinephrine; Eye; Male; Ophthalmic Solutions; Pilocarpine; Rabbits; Timolol | 1991 |
Effects of D-timolol and L-timolol on ocular blood flow and intraocular pressure.
Topics: Administration, Topical; Animals; Choroid; Eye; Female; Injections, Intravenous; Intraocular Pressure; Male; Rabbits; Regional Blood Flow; Retinal Vessels; Stereoisomerism; Timolol | 1990 |
Trifluridine decreases ocular HSV-1 recovery, but not herpetic lesions after timolol iontophoresis.
Topics: Animals; Eye; Iontophoresis; Keratitis, Dendritic; Rabbits; Simplexvirus; Thymidine; Timolol; Trifluridine | 1989 |
Microvascular access to the uveal tract in the rabbit eye for ocular pharmacologic studies.
Topics: Animals; Catheterization, Peripheral; Dose-Response Relationship, Drug; Eye; Insulin; Intraocular Pressure; Microcirculation; Pharmaceutical Preparations; Pilocarpine; Rabbits; Timolol; Uvea | 1989 |
Effects of stimulation of the ocular sympathetic nerves on IOP and aqueous humor flow.
Topics: Animals; Anterior Chamber; Aqueous Humor; Electric Stimulation; Eye; Female; Intraocular Pressure; Male; Phentolamine; Rabbits; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sympathetic Nervous System; Timolol | 1987 |
[Kinetics of drugs in ophthalmology].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Animals; Anti-Bacterial Agents; Eye; Eye Diseases; Humans; Kinetics; Ophthalmic Solutions; Pharmaceutical Preparations; Timolol; Tissue Distribution | 1985 |
Topical timolol, at conventional, unilateral doses causes bilateral ocular beta-blockade in rabbits.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Eye; Female; Heart Rate; Intraocular Pressure; Isoproterenol; Male; Rabbits; Time Factors; Timolol | 1987 |
Tolerability of timolol and betaxolol in patients with chronic open-angle glaucoma.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Betaxolol; Chronic Disease; Drug Tolerance; Eye; Female; Glaucoma, Open-Angle; Humans; Male; Middle Aged; Ophthalmic Solutions; Propanolamines; Timolol | 1987 |
Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol.
Topics: Adrenergic beta-Antagonists; Animals; Eye; Heart; Heart Rate; Intraocular Pressure; Isoproterenol; Levobunolol; Male; Prodrugs; Rabbits; Timolol | 1988 |
Peripheral adrenergic stimulation and indomethacin in experimental ocular shedding of HSV.
Topics: Animals; Eye; Hydroxydopamines; Indomethacin; Keratitis, Dendritic; Oxidopamine; Rabbits; Simplexvirus; Stimulation, Chemical; Sympathomimetics; Timolol | 1987 |
Timolol promotes reactivation of latent HSV-1 in the mouse iontophoresis model.
Topics: Animals; Eye; Ganglia; Iontophoresis; Male; Mice; Mice, Inbred BALB C; Reaction Time; Simplexvirus; Timolol; Trigeminal Nerve; Virus Activation | 1987 |
Timolol induces HSV-1 ocular shedding in the latently infected rabbit.
Topics: Administration, Topical; Animals; Eye; Iontophoresis; Keratitis, Dendritic; Rabbits; Simplexvirus; Timolol | 1987 |
Timolol binding to bovine ocular melanin in vitro.
Topics: Animals; Binding, Competitive; Cattle; Ethanol; Eye; Hydrogen-Ion Concentration; In Vitro Techniques; Iris; Kinetics; Melanins; Propranolol; Stereoisomerism; Timolol | 1988 |
Ocular hypotensive effects of monoamine oxidase-A inhibitors in rabbit.
Topics: Animals; Drug Synergism; Epinephrine; Eye; Intraocular Pressure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pupil; Rabbits; Time Factors; Timolol; Tissue Distribution | 1988 |
Application site dependent ocular absorption of timolol.
Topics: Absorption; Administration, Topical; Animals; Ciliary Body; Conjunctiva; Cornea; Drug Administration Routes; Eye; Iris; Rabbits; Sclera; Timolol; Vitreous Body | 1988 |
Regional ocular blood flow after chronic topical glaucoma drug treatment.
Topics: Animals; Drug Evaluation, Preclinical; Echothiophate Iodide; Epinephrine; Eye; Glaucoma; Microspheres; Norepinephrine; Pilocarpine; Rabbits; Regional Blood Flow; Timolol | 1987 |
Bilateral effects of monocular timolol treatment.
Topics: Eye; Humans; Intraocular Pressure; Male; Middle Aged; Timolol | 1986 |
Effects of antiglaucoma drugs on the blood flow in rabbit eyes.
Topics: Animals; Blood Flow Velocity; Butyrophenones; Drug Evaluation, Preclinical; Eye; Glaucoma; Haloperidol; Intraocular Pressure; Pilocarpine; Rabbits; Timolol; Trifluperidol | 1986 |
Lack of metabolism of timolol by ocular tissues.
Topics: Animals; Chromatography, High Pressure Liquid; Culture Techniques; Eye; Liver; Macaca fascicularis; Rabbits; Timolol | 1985 |
Attempt to arrest eye growth by means of ocular hypotony.
Topics: Animals; Eye; Intraocular Pressure; Timolol; Ultrasonography | 1985 |
Potential systemic and ocular side effects associated with topical administration of timolol maleate.
Topics: Eye; Humans; Ophthalmic Solutions; Timolol | 1985 |
[A study of arterially perfused enucleated eye--drug effects on aqueous humor formation].
Topics: Acetazolamide; Animals; Aqueous Humor; Epinephrine; Eye; In Vitro Techniques; Organ Preservation; Ouabain; Perfusion; Pilocarpine; Rabbits; Timolol | 1985 |
Blood flow in aphakic rabbit eyes after sub-chronic glaucoma drug treatment.
Topics: Animals; Aphakia; Choroid; Ciliary Body; Echothiophate Iodide; Epinephrine; Eye; Intraocular Pressure; Iris; Norepinephrine; Optic Nerve; Pilocarpine; Rabbits; Regional Blood Flow; Retinal Vessels; Timolol | 1985 |
Timolol and pilocarpine are hypotensive in light-induced avian glaucoma.
Topics: Animals; Aqueous Humor; Chickens; Eye; Glaucoma; Injections, Intravenous; Intraocular Pressure; Light; Pilocarpine; Radiation Injuries, Experimental; Timolol | 1985 |
Ocular penetration of beta-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Atenolol; Carbon Radioisotopes; Ciliary Body; Cornea; Eye; Female; Iris; Male; Metoprolol; Nictitating Membrane; Propranolol; Rabbits; Timolol; Tritium | 1980 |
Pharmacological effects of topical timolol in the rabbit eye.
Topics: Adrenergic beta-Antagonists; Animals; Ciliary Body; Cyclic AMP; Eye; In Vitro Techniques; Intraocular Pressure; Iris; Isoproterenol; Propanolamines; Rabbits; Timolol | 1980 |
Effects of selective beta 1- and beta 2-adrenoreceptor agonists and antagonists on intraocular pressure in the cat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Atenolol; Carbachol; Cats; Dose-Response Relationship, Drug; Echothiophate Iodide; Eye; Female; Intraocular Pressure; Male; Sympathectomy; Timolol | 1981 |
The effect of timolol maleate on the disruption of the blood-aqueous barrier in the rabbit eye.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Aqueous Humor; Eye; Melanocyte-Stimulating Hormones; Propanolamines; Prostaglandins E; Rabbits; Timolol | 1981 |
The effect of beta blocking drugs and carboxyanhydrase inhibitors on the standing potential of the eye.
Topics: Acetazolamide; Action Potentials; Adrenergic beta-Antagonists; Adult; Carbonic Anhydrase Inhibitors; Electrooculography; Eye; Humans; Timolol | 1980 |
Beta-adrenergic blockers: ocular penetration and binding to the uveal pigment.
Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Cornea; Eye; Permeability; Pigment Epithelium of Eye; Propanolamines; Rabbits; Time Factors; Timolol; Uvea | 1982 |
[A preliminary study of effects of beta-blockers and benzalkonium chloride on pigmented rabbit's eye; electrophysiological and morphological studies].
Topics: Adrenergic beta-Antagonists; Animals; Benzalkonium Compounds; Electroretinography; Eye; Female; Male; Preservatives, Pharmaceutical; Propanolamines; Rabbits; Retinal Pigments; Timolol | 1983 |
Filtering valve implant for neovascular glaucoma in proliferative diabetic retinopathy.
Topics: Adult; Cryosurgery; Diabetic Retinopathy; Equipment Failure; Eye; Female; Filtration; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Lasers; Neovascularization, Pathologic; Timolol | 1982 |
Topical timolol and epinephrine: biochemical actions and interactions in the rabbit eye in vivo.
Topics: Administration, Topical; Animals; Aqueous Humor; Cyclic AMP; Drug Combinations; Epinephrine; Eye; Propanolamines; Rabbits; Timolol | 1983 |
Effect of topical epinephrine and timolol on ocular and optic nerve blood flow in phakic and aphakic rabbit eyes.
Topics: Animals; Aphakia; Choroid; Ciliary Body; Epinephrine; Eye; Female; Intraocular Pressure; Iris; Male; Optic Nerve; Rabbits; Regional Blood Flow; Retinal Vessels; Timolol | 1984 |
Effects of timolol on intraocular pressure following ocular adrenergic denervation.
Topics: Animals; Eye; Ganglia, Sympathetic; Intraocular Pressure; Rabbits; Receptors, Adrenergic; Timolol | 1984 |
The treatment of acute angle-closure glaucoma revisited.
Topics: Acetazolamide; Acute Disease; Aged; Drug Therapy, Combination; Eye; Glaucoma; Humans; Middle Aged; Pilocarpine; Timolol | 1984 |
Side effects of timolol.
Topics: Administration, Topical; Cardiovascular System; Central Nervous System; Eye; Humans; Respiration; Timolol | 1983 |
Safe use of ocular drugs in the elderly.
Topics: Adrenal Cortex Hormones; Aged; Anesthetics, Local; Epinephrine; Eye; Humans; Ophthalmic Solutions; Parasympatholytics; Phenylephrine; Thimerosal; Timolol | 1984 |
Disposition of ophthalmic timolol in treated and untreated rabbit eyes. A multiple and single dose study.
Topics: Albinism; Animals; Eye; Ophthalmic Solutions; Rabbits; Timolol; Tissue Distribution | 1984 |
The effect of d-timolol on intraocular pressure in patients with ocular hypertension.
Topics: Administration, Topical; Adult; Aged; Blood Pressure; Double-Blind Method; Drug Evaluation; Eye; Female; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Pupil; Random Allocation; Stereoisomerism; Timolol; Visual Acuity | 1984 |
[Timolol effects in the rabbit eye (author's transl)].
Topics: Animals; Eye; Intraocular Pressure; Propanolamines; Rabbits; Timolol | 1982 |
[Timolol maleate: pharmacokinetic analysis of ocular penetration in the rabbit eye and effects on human aqueous humor dynamics (author's transl)].
Topics: Adult; Animals; Aqueous Humor; Eye; Humans; Male; Ophthalmic Solutions; Propanolamines; Rabbits; Timolol | 1980 |
Effect of timolol maleate on intraocular pressure and pupil cycle time in normal eyes.
Topics: Administration, Topical; Adult; Drug Administration Schedule; Eye; Humans; Intraocular Pressure; Maleates; Propanolamines; Reflex, Pupillary; Timolol | 1981 |
Penetration of timolol into the rabbit eye. Measurements after ocular instillation and intravenous injection.
Topics: Administration, Topical; Animals; Aqueous Humor; Carbon Radioisotopes; Chromatography, Gas; Eye; Injections, Intravenous; Propanolamines; Rabbits; Scintillation Counting; Time Factors; Timolol; Tissue Distribution | 1980 |
The effect of topical beta-blocker medications on the proliferation and viability of human Tenon's capsule fibroblasts in tissue culture.
Topics: Adrenergic beta-Antagonists; Benzalkonium Compounds; Carteolol; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Eye; Fascia; Fibroblasts; Humans; Levobunolol; Ophthalmic Solutions; Timolol | 1995 |
Plasma kinetics and antagonist activity of topical ocular timolol in elderly patients.
Topics: Absorption; Administration, Topical; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Aged; Aged, 80 and over; Cataract Extraction; Eye; Humans; Lenses, Intraocular; Middle Aged; Ophthalmic Solutions; Radioligand Assay; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Timolol | 1995 |
Controlled ocular timolol delivery: systemic absorption and intraocular pressure effects in humans.
Topics: Absorption; Aged; Drug Delivery Systems; Eye; Female; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Silicones; Timolol | 1994 |
Ocular timolol levels after drug withdrawal: an experimental model.
Topics: Animals; Aqueous Humor; Eye; Melanins; Models, Biological; Ophthalmic Solutions; Pigment Epithelium of Eye; Rabbits; Timolol; Tissue Distribution; Uvea | 1994 |
Systemic absorption pathways of topically applied beta adrenergic antagonists in the pigmented rabbit.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Atenolol; Betaxolol; Biological Availability; Conjunctiva; Eye; Levobunolol; Male; Nasal Mucosa; Nasolacrimal Duct; Rabbits; Time Factors; Timolol | 1993 |
Influence of drug release rate on systemic timolol absorption from polymeric ocular inserts in the pigmented rabbit.
Topics: Absorption; Animals; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Carriers; Eye; Eyelids; Male; Polymers; Rabbits; Suppositories; Timolol | 1994 |
The effect of topical pilocarpine on pulsatile ocular blood flow.
Topics: Administration, Topical; Aged; Drug Therapy, Combination; Eye; Glaucoma, Open-Angle; Humans; Middle Aged; Pilocarpine; Pulsatile Flow; Regional Blood Flow; Timolol | 1993 |
Drug effects on intraocular pressure and vascular flow in the bovine perfused eye using radiolabelled microspheres.
Topics: Adrenergic beta-Antagonists; Animals; Blood Flow Velocity; Carteolol; Cattle; Cerium Radioisotopes; Choroid; Ciliary Body; Eye; Intraocular Pressure; Iris; Microspheres; Nitroprusside; Perfusion; Regional Blood Flow; Timolol; Vasodilator Agents; Verapamil | 1995 |
Comparison of concentration-time profiles of levobunolol and timolol in anterior and posterior ocular tissues of albino rabbits.
Topics: Absorption; Adrenergic beta-Antagonists; Animals; Aqueous Humor; Biological Availability; Choroid; Ciliary Body; Eye; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Iris; Levobunolol; Ophthalmic Solutions; Optic Nerve; Rabbits; Retina; Timolol; Tissue Distribution; Vitreous Body | 1995 |
Vaninolol: a novel compound for the treatment of glaucoma and ischemic retinopathy.
Topics: Adrenergic beta-Antagonists; Animals; Blood Flow Velocity; Butanones; Electroretinography; Eye; Female; Glaucoma; Intraocular Pressure; Ischemia; Male; Microspheres; Ocular Hypertension; Propanolamines; Rabbits; Rats; Retina; Retinal Artery; Retinal Artery Occlusion; Timolol | 1995 |
Pharmacokinetic differences between ocular inserts and eyedrops.
Topics: Absorption; Animals; Delayed-Action Preparations; Eye; Male; Models, Biological; Ophthalmic Solutions; Rabbits; Timolol | 1996 |
Effects of pilocarpine and other antiglaucoma drugs on cultured human Tenon's fibroblast cells.
Topics: Adrenergic beta-Antagonists; Betaxolol; Carteolol; Cell Division; Cells, Cultured; Eye; Fibroblasts; Glaucoma; Humans; Levobunolol; Muscarinic Agonists; Pilocarpine; Thymidine; Timolol | 1997 |
[Ophthalmic mucoadhesive vehicles: preliminary study of ocular pharmacokinetics "in vivo"].
Topics: Adhesiveness; Adrenergic beta-Antagonists; Animals; Eye; Mucous Membrane; Ophthalmic Solutions; Polymers; Rabbits; Timolol | 1996 |
In-situ ocular absorption of ophthalmic beta-blockers through ocular membranes in albino rabbits.
Topics: Absorption; Adrenergic beta-Antagonists; Animals; Carteolol; Conjunctiva; Cornea; Eye; Male; Propanolamines; Rabbits; Sclera; Timolol | 1997 |
Ocular-specific delivery of timolol by sequential bioactivation of its oxime and methoxime analogs.
Topics: Administration, Topical; Adrenergic beta-Agonists; Animals; Eye; Hydrolysis; Intraocular Pressure; Isoproterenol; Kinetics; Male; Rabbits; Rats; Rats, Sprague-Dawley; Tachycardia; Timolol | 1997 |
Bioavailability of timolol and aceclidine after ocular instillation in the rabbit.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Aqueous Humor; Area Under Curve; Biological Availability; Eye; Half-Life; Male; Parasympathomimetics; Pupil; Quinuclidines; Rabbits; Spectrophotometry, Ultraviolet; Timolol | 1998 |
Discoidal niosome based controlled ocular delivery of timolol maleate.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Delayed-Action Preparations; Drug Delivery Systems; Eye; Female; Hydrogen-Ion Concentration; Intraocular Pressure; Male; Micelles; Polyethylene Glycols; Rabbits; Surface-Active Agents; Timolol | 1998 |
Characterization of ocular pharmacokinetics of beta-blockers using a diffusion model after instillation.
Topics: Absorption; Administration, Topical; Adrenergic beta-Antagonists; Algorithms; Animals; Anterior Chamber; Aqueous Humor; Cornea; Dextrans; Diffusion; Eye; Fluorescein-5-isothiocyanate; Isoquinolines; Models, Biological; Rabbits; Timolol | 1999 |
Drug release from cation exchange membrane in rabbit eye.
Topics: Acrylic Resins; Adsorption; Animals; Cations; Chromatography, High Pressure Liquid; Conjunctiva; Eye; Ion Exchange; Male; Membranes, Artificial; Osmolar Concentration; Polyvinyls; Propranolol; Rabbits; Timolol | 1999 |
Short-term effect of beta-adrenoreceptor blocking agents on ocular blood flow.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Betaxolol; Blood Flow Velocity; Blood Pressure; Carteolol; Choroid; Ciliary Body; Eye; Heart Rate; Intraocular Pressure; Rabbits; Random Allocation; Regional Blood Flow; Retinal Vessels; Timolol; Vascular Resistance | 2001 |
[The effect of three kinds of anti-glaucoma eyedrops on ocular blood flow].
Topics: Adult; Aged; Epinephrine; Eye; Female; Fluorescein Angiography; Glaucoma; Humans; Levobunolol; Male; Middle Aged; Ophthalmic Solutions; Regional Blood Flow; Timolol | 2000 |
Effects of a beta-adrenergic blocking agent timolol on intra ocular pressure responses induced by stimulation of cervical sympathetic nerve in the cat.
Topics: Adrenergic beta-Antagonists; Adrenergic Fibers; Animals; Cats; Cervical Vertebrae; Electric Stimulation; Eye; Intraocular Pressure; Timolol | 2001 |
Timolol concentrations in rat ocular tissues and plasma after topical and intraperitoneal dosing.
Topics: Absorption; Administration, Topical; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Biological Availability; Chromatography, High Pressure Liquid; Eye; Injections, Intraperitoneal; Intraocular Pressure; Rats; Rats, Long-Evans; Timolol; Tissue Distribution | 2002 |
Bioavailability in the human eye of a fixed combination of latanoprost and timolol compared to monotherapy.
Topics: Absorption; Aged; Aqueous Humor; Biological Availability; Drug Combinations; Eye; Female; Half-Life; Humans; Intraocular Pressure; Latanoprost; Male; Prostaglandins F, Synthetic; Time Factors; Timolol | 2002 |
[Physiologic significance of the interaction between timolol and free amino acids in eye structures].
Topics: Adrenergic beta-Antagonists; Amino Acids; Autoradiography; Chromatography, Thin Layer; Eye; Glaucoma, Open-Angle; Timolol | 2002 |
The pulsatile ocular blood flow behaviour in open angle glaucoma patients after replacing timolol therapy with timolol and dorzolamide fixed combination: preliminary study.
Topics: Adrenergic beta-Antagonists; Aged; Blood Flow Velocity; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Pulsatile Flow; Sulfonamides; Thiophenes; Timolol | 2002 |
[Glaucoma: an ocular blood flow disorder?].
Topics: Adrenergic beta-Antagonists; Adult; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Eye; Female; Glaucoma; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Rheology; Risk Factors; Sulfonamides; Thiophenes; Time Factors; Timolol | 2003 |
Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.
Topics: Adrenergic beta-Antagonists; Adult; Contrast Media; Cornea; Epithelium, Corneal; Eye; Female; Fluorescein; Humans; Irritants; Levobunolol; Male; Middle Aged; Reference Values; Solutions; Tears; Timolol | 2003 |
Vitamin B2-sensitised photooxidation of the ophthalmic drugs Timolol and Pindolol: kinetics and mechanism.
Topics: Adrenergic beta-Antagonists; Animals; Anions; Electrons; Eye; Free Radicals; Kinetics; Light; Models, Chemical; Oxygen; Oxygen Consumption; Photosensitizing Agents; Pindolol; Reactive Oxygen Species; Riboflavin; Spectrophotometry; Time Factors; Timolol; Ultraviolet Rays | 2004 |
Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system.
Topics: Adhesives; Animals; Drug Delivery Systems; Eye; Liposomes; Male; Ophthalmic Solutions; Rabbits; Timolol | 2005 |
A mathematical model for ocular tear and solute balance.
Topics: Eye; Homeostasis; Humans; Instillation, Drug; Models, Biological; Ophthalmic Solutions; Osmolar Concentration; Surface Tension; Tears; Timolol | 2005 |
Ocular powder: dry topical formulations of timolol are well tolerated in rabbits.
Topics: Animals; Aqueous Humor; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eye; Feasibility Studies; Female; Male; Powders; Rabbits; Radiography; Reproducibility of Results; Timolol | 2006 |
Resistance to blood flow in the rabbit ophthalmic artery after topical treatment with timolol.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Blood Flow Velocity; Blood Pressure; Dose-Response Relationship, Drug; Eye; Heart Rate; Intraocular Pressure; Ophthalmic Artery; Rabbits; Regional Blood Flow; Timolol; Ultrasonography, Doppler, Color | 2007 |
Biodegradable fumarate-based drug-delivery systems for ophthalmic applications.
Topics: Acetazolamide; Animals; Antihypertensive Agents; Biocompatible Materials; Carbonic Anhydrase Inhibitors; Chromatography, High Pressure Liquid; Dichlorphenamide; Diuretics; Drug Carriers; Drug Delivery Systems; Eye; Fumarates; Implants, Experimental; Molecular Structure; Polypropylenes; Rabbits; Timolol | 2009 |
Ocular pharmacokinetic/pharmacodynamic modeling for timolol in rabbits using a telemetry system.
Topics: Adrenergic beta-Antagonists; Algorithms; Animals; Eye; Injections; Intraocular Pressure; Male; Rabbits; Telemetry; Timolol | 2008 |
The effect of timolol maleate on tear film break-up time in Nigerians.
Topics: Adrenergic beta-Agonists; Adult; Aged; Case-Control Studies; Dry Eye Syndromes; Eye; Female; Glaucoma, Open-Angle; Humans; Male; Middle Aged; Nigeria; Surveys and Questionnaires; Tears; Time Factors; Timolol | 2008 |
Matrix modifications modulate ophthalmic drug delivery from photo-cross-linked poly(propylene fumarate)-based networks.
Topics: Acetazolamide; Antihypertensive Agents; Diuretics; Drug Administration Routes; Drug Carriers; Drug Delivery Systems; Eye; Fumarates; Molecular Structure; Ophthalmic Solutions; Polyethylene Glycols; Polymers; Polypropylenes; Timolol | 2009 |
Effectiveness of dorzolamide–timolol (COSOPT) in patients who were treatment naive for open-angle glaucoma or ocular hypertension: the COSOPT first-line study.
Topics: Aged; Drug Combinations; Eye; Female; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Multicenter Studies as Topic; Ocular Hypertension; Ophthalmic Solutions; Prostaglandins F, Synthetic; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Treatment Outcome | 2010 |
Time course of changes in ocular aberrations after instillation of carteolol long-acting solution and timolol gel-forming solution.
Topics: Adrenergic beta-Antagonists; Adult; Carteolol; Eye; Female; Gels; Humans; Male; Ophthalmic Solutions; Timolol | 2011 |
Characterization of intraocular pressure responses of the Tibetan monkey (Macaca thibetana).
Topics: Animals; Antihypertensive Agents; Circadian Rhythm; Cloprostenol; Eye; Glaucoma; Intraocular Pressure; Macaca; Male; Models, Animal; Naphazoline; Pyrrolidines; Timolol; Tonometry, Ocular; Travoprost | 2011 |
New mucoadhesive chitosan film for ophthalmic drug delivery of timolol maleate: in vivo evaluation.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Calorimetry, Differential Scanning; Chitosan; Drug Delivery Systems; Eye; Intraocular Pressure; Male; Ophthalmic Solutions; Rabbits; Solubility; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Timolol; Tissue Adhesives; Water | 2012 |
The effects of a fixed combination of 0.5% timolol and 1% dorzolamide on optic nerve head blood circulation.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Blood Pressure; Carbonic Anhydrase Inhibitors; Drug Combinations; Drug Synergism; Eye; Female; Heart Rate; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Optic Disk; Perfusion; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol; Young Adult | 2012 |
Extended drug delivery by contact lenses for glaucoma therapy.
Topics: Animals; Antihypertensive Agents; Contact Lenses, Extended-Wear; Dogs; Drug Delivery Systems; Eye; Glaucoma; Intraocular Pressure; Ophthalmic Solutions; Timolol; Vitamin E | 2012 |
In vivo evaluation and in-depth pharmaceutical characterization of a rapidly dissolving solid ocular matrix for the topical delivery of timolol maleate in the rabbit eye model.
Topics: Administration, Ophthalmic; Animals; Antihypertensive Agents; Chick Embryo; Chorioallantoic Membrane; Drug Delivery Systems; Eye; In Vitro Techniques; Ophthalmic Solutions; Permeability; Rabbits; Solubility; Timolol | 2014 |
Paroxetine markedly increases plasma concentrations of ophthalmic timolol; CYP2D6 inhibitors may increase the risk of cardiovascular adverse effects of 0.5% timolol eye drops.
Topics: Adult; Area Under Curve; Cardiovascular Diseases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Eye; Heart Rate; Humans; Male; Ophthalmic Solutions; Paroxetine; Risk; Timolol; Young Adult | 2014 |
The transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes.
Topics: Animals; Benzalkonium Compounds; Chromatography, Liquid; Cloprostenol; Cornea; Drug Combinations; Eye; Glaucoma; Male; Ophthalmic Solutions; Preservatives, Pharmaceutical; Prostaglandins F, Synthetic; Rabbits; Sulfonamides; Thiophenes; Timolol | 2015 |
Chitosan derivatives as effective nanocarriers for ocular release of timolol drug.
Topics: Chemistry, Pharmaceutical; Chitosan; Drug Carriers; Drug Liberation; Eye; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Polyphosphates; Spectroscopy, Fourier Transform Infrared; Succinic Anhydrides; Timolol; X-Ray Diffraction | 2015 |
Comparison of Ocular Pulse Amplitude Lowering Effects of Preservative-Free Tafluprost and Preservative-Free Dorzolamide-Timolol Fixed Combination Eyedrops.
Topics: Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Low Tension Glaucoma; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Preservatives, Pharmaceutical; Prostaglandins F; Retrospective Studies; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2015 |
Drug Distribution to Retinal Pigment Epithelium: Studies on Melanin Binding, Cellular Kinetics, and Single Photon Emission Computed Tomography/Computed Tomography Imaging.
Topics: Animals; Cells, Cultured; Chloroquine; Eye; Hydrogen-Ion Concentration; Iodine Radioisotopes; Kinetics; Melanins; Methotrexate; Nadolol; Protein Binding; Rats; Retinal Pigment Epithelium; Single Photon Emission Computed Tomography Computed Tomography; Swine; Timolol | 2016 |
Effects of dorzolamide/timolol fixed combination on retrobulbar hemodynamics in pseudoexfoliative glaucoma.
Topics: Aged; Carbonic Anhydrase Inhibitors; Cross-Sectional Studies; Drug Combinations; Exfoliation Syndrome; Eye; Female; Hemodynamics; Humans; Male; Middle Aged; Prospective Studies; Regional Blood Flow; Retinal Artery; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2016 |
Self-Assembling Elastin-Like Hydrogels for Timolol Delivery: Development of an Ophthalmic Formulation Against Glaucoma.
Topics: Animals; Antihypertensive Agents; Calorimetry, Differential Scanning; Cell Line; Drug Carriers; Drug Liberation; Elastin; Eye; Fibroblasts; Glaucoma; Humans; Hydrogels; Intraocular Pressure; Male; Models, Animal; Ophthalmic Solutions; Rabbits; Rheology; Silk; Timolol; Treatment Outcome | 2017 |
Changes in Ocular Hemodynamics after Carotid Artery Angioplasty and Stenting (CAAS) in Patients with Different Severity of Ocular Ischemic Syndrome.
Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon; Blood Flow Velocity; Carbonic Anhydrase Inhibitors; Carotid Artery, Internal; Carotid Stenosis; Drug Therapy, Combination; Eye; Female; Humans; Intraocular Pressure; Iris; Ischemia; Laser Coagulation; Male; Neovascularization, Pathologic; Ophthalmic Artery; Prospective Studies; Retinal Vessels; Stents; Sulfonamides; Thiazines; Timolol; Ultrasonography, Doppler, Color; Visual Acuity | 2018 |
Effect of gold nanoparticles on timolol uptake and its release kinetics from contact lenses: In vitro and in vivo evaluation.
Topics: Animals; Contact Lenses; Drug Liberation; Eye; Gold; Intraocular Pressure; Kinetics; Metal Nanoparticles; Rabbits; Timolol; Tissue Distribution | 2019 |
Computational Model of In Vivo Corneal Pharmacokinetics and Pharmacodynamics of Topically Administered Ophthalmic Drug Products.
Topics: Administration, Topical; Animals; Cornea; Eye; Humans; Ophthalmic Solutions; Rabbits; Timolol | 2023 |