Page last updated: 2024-08-16

timolol and clonidine

timolol has been researched along with clonidine in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (29.17)	18.7374
1990's	24 (33.33)	18.2507
2000's	19 (26.39)	29.6817
2010's	7 (9.72)	24.3611
2020's	1 (1.39)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Neufeld, AH; Page, ED	1
Brubaker, RF; Koskela, T	1
Arkin, LM; Cummings, HL; Robin, AL; Sulewski, ME	1
Lee, SH; Lee, SY; Parrow, KA; Shin, DH; Yaldo, MK	1
Carabine, UA; Milligan, KR; Moore, JA	1
Brubaker, RF; Gharagozloo, NZ	1
Coleman, AL; Robin, AL	1
Lewis, RA; Shields, MB; Wilkerson, M	1
Tost, M	1
Robin, AL	1
Bacon, DR; Fahrenbach, WF; Van Buskirk, EM	1
Morrison, JC; Robin, AL	1
Dandona, L; Morrison, JC; Quigley, HA; Robin, AL	1
Cherian, L; Klemm, WR; Sukul, NC	1
Burke, JA; Potter, DE	1
Andersen, KS; Grong, K; Lekven, J; Stangeland, L; Vik-Mo, H	1
Blask, DE; Stockmeier, CA	1
Brunner, HR; Nussberger, J; Waeber, B	1
Clark, BG; Vestal, RE	1
Jounela, AJ; Juustila, HJ; Lilja, M; Paalzow, L	1
Ciracì, G; Giummarra, C; Reibaldi, A	1
Hopkins, GA	1
Agnoli, A; Barbieri, RM; De Marinis, M; Feliciani, M; Grillo, G	1
Dunwiddie, TV; Hoffer, BJ; Mueller, AL	1
Gross, G; Täumer, R	1
Junker, C; Junker, H	1
Lehmann, RP; Ritch, R; Shin, DH; Shrader, CE; Stewart, WC; van Buskirk, EM	1
Dartt, DA; Dicker, DM; Hodges, RR; Ronco, LV; Rose, PE	1
Alimgil, ML; Benian, O; Erda, S	1
Chuniaud, M; Demailly, P; Hitchings, RA; Nagasubramanian, S; Pannarale, MR; Parsons, DG; Pecori-Giraldi, J; Stodtmeister, R	1
Bausher, L; Horio, B; Matsui, H; Mead, A; Sears, M	1
Horwitz, B; Kottler, M; Laibovitz, R; Ritch, R; Stewart, RH; Stewart, WC	1
Agarwal, HC; Rajashekar, YL; Sihota, R	1
Alçelik, T; Caglar, Y; Elibol, O; Yüksel, N	1
Lee, MS; Pasha, M; Weitzman, M	1
Burnstein, Y; Higginbotham, EJ; Shelton, K	1
Brubaker, R; Dinslage, S; McLaren, J	1
Schwartz, M; Wheeler, LA; Yoles, E	1
Kaya, M; Mete, U; Ozdemir, N; Polat, S; Soylu, M; Unlügenç, Z	1
Brubaker, RF; Maus, TL; Nau, C	1
Kaufman, PF	1
Konstas, AG; Maltezos, A; Mantziris, DA; Sine, CS; Stewart, WC	1
Cheung, J; Sharma, S	1
Connor, TB; Dev, S; Han, DP; Mieler, WF; Mittra, RA; Pollack, JS; Pulido, JS	1
Dluzen, DE; Ebner, K; Engelmann, M; Landgraf, R; Muraoka, S	1
Ciranna, L; Li Volsi, G; Licata, F; Santangelo, F	1
Barbier, A; Elena, PP; Lacheretz, F; Le Fur, G; Maffrand, JP; Serradeil-Le Gal, C	1
Oruç, S; Sener, EC	1
Chua, JK; Lai, JS; Lam, DS; Tham, CC	1
Agarwal, H; Rajashekhar, YL; Sihota, R; Venkatesh, P	1
Bronzi, D; Di Mauro, M; Li Volsi, G; Licata, F; Lombardo, P; Santangelo, F	1
Besada, E; Frauens, BJ; Shechtman, D	1
Barresi, M; Caldera, M; Grasso, C; Li Volsi, G; Licata, F; Santangelo, F	1
Dot, C; El Chehab, H; Giraud, JM; Le Corre, A; Ract-Madoux, G; Swalduz, B	1
Alagoz, G; Altun, G; Celik, E; Turkoglu, EB	1
Asghari, A; Ozmaie, S; Rajaei, SM; Ziadi, A	1

Reviews

4 review(s) available for timolol and clonidine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug treatment of glaucoma. American journal of optometry and physiological optics, 1984, Volume: 61, Issue:12 Topics: Acetazolamide; Administration, Topical; Adrenergic beta-Antagonists; Bromocriptine; Clonidine; Dronabinol; Epinephrine; Glaucoma; Humans; Labetalol; Miotics; Nadolol; Parasympathomimetics; Pilocarpine; Propanolamines; Sympathomimetics; Timolol	1984
[Report on the application of chibro-timoptol after one year's use in ophthalmological practice (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1980, Volume: 177, Issue:3 Topics: Acetazolamide; Clonidine; Glaucoma; Humans; Pilocarpine; Propanolamines; Timolol	1980
Assessment of ocular hypotensive mechanisms and additivity of antiglaucoma drugs in humans. Archives of ophthalmology (Chicago, Ill. : 1960), 1999, Volume: 117, Issue:5 Topics: Administration, Topical; Adrenergic alpha-Agonists; Aqueous Humor; Brimonidine Tartrate; Clonidine; Drug Synergism; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Timolol	1999

Trials

24 trial(s) available for timolol and clonidine

Article	Year
Apraclonidine and timolol. Combined effects in previously untreated normal subjects. Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:6 Topics: Administration, Topical; Adrenergic alpha-Agonists; Aqueous Humor; Circadian Rhythm; Clonidine; Drug Therapy, Combination; Fluorescein; Fluoresceins; Humans; Intraocular Pressure; Random Allocation; Timolol	1991
Effects of topical flurbiprofen on the intraocular pressure lowering effects of apraclonidine and timolol. Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:6 Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Clonidine; Double-Blind Method; Evaluation Studies as Topic; Female; Flurbiprofen; Humans; Intraocular Pressure; Male; Middle Aged; Premedication; Prospective Studies; Timolol	1991
Additive effect of 1% apraclonidine hydrochloride to nonselective beta-blockers. Ophthalmology, 1991, Volume: 98, Issue:7 Topics: Adrenergic alpha-Agonists; Clonidine; Double-Blind Method; Drug Synergism; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Levobunolol; Male; Ocular Hypertension; Prospective Studies; Random Allocation; Timolol	1991
Adrenergic modulation of preoperative anxiety: a comparison of temazepam, clonidine, and timolol. Anesthesia and analgesia, 1991, Volume: 73, Issue:5 Topics: Adult; Anti-Anxiety Agents; Anxiety; Clonidine; Female; Humans; Hypnotics and Sedatives; Male; Preanesthetic Medication; Temazepam; Timolol	1991
Effect of apraclonidine in long-term timolol users. Ophthalmology, 1991, Volume: 98, Issue:10 Topics: Adrenergic alpha-Agonists; Aged; Aqueous Humor; Clonidine; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Secretory Rate; Timolol	1991
Apraclonidine hydrochloride: an evaluation of plasma concentrations, and a comparison of its intraocular pressure lowering and cardiovascular effects to timolol maleate. Transactions of the American Ophthalmological Society, 1990, Volume: 88 Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Clonidine; Double-Blind Method; Evaluation Studies as Topic; Female; Heart Rate; Hemodynamics; Humans; Intraocular Pressure; Middle Aged; Ophthalmic Solutions; Prospective Studies; Timolol	1990
Follicular conjunctivitis associated with apraclonidine. American journal of ophthalmology, 1991, Jan-15, Volume: 111, Issue:1 Topics: Adult; Clonidine; Conjunctivitis; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Timolol	1991
Adjunctive glaucoma therapy. A comparison of apraclonidine to dipivefrin when added to timolol maleate. Ophthalmology, 1989, Volume: 96, Issue:1 Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Drug Therapy, Combination; Epinephrine; Eye Diseases; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Timolol	1989
"Outlier" intraocular pressure readings: valid or invalid for statistical analysis? Ophthalmic surgery, 1989, Volume: 20, Issue:10 Topics: Analysis of Variance; Clinical Trials as Topic; Clonidine; Data Interpretation, Statistical; Double-Blind Method; Drug Therapy, Combination; Epinephrine; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Random Allocation; Timolol	1989
Shortcomings of office blood pressures in assessing antihypertensive therapy. Clinical and experimental hypertension. Part A, Theory and practice, 1985, Volume: 7, Issue:2-3 Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Clonidine; Diuretics; Humans; Hypertension; Methyldopa; Timolol	1985
The efficacy of apraclonidine as an adjunct to timolol therapy. Apraclonidine Adjunctive Therapy Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1995, Volume: 113, Issue:3 Topics: Adrenergic alpha-Agonists; Chemotherapy, Adjuvant; Clonidine; Double-Blind Method; Drug Administration Schedule; Drug Synergism; Drug Tolerance; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Timolol	1995
[The additive effect of dipivefrin in patients with wide angle glaucoma treated with long-term beta-blocker therapy in comparison with clonidine]. Klinische Monatsblatter fur Augenheilkunde, 1994, Volume: 205, Issue:2 Topics: Clonidine; Drug Synergism; Drug Therapy, Combination; Epinephrine; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Timolol	1994
Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study. Ophthalmology, 1993, Volume: 100, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Clonidine; Double-Blind Method; Drug Administration Schedule; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Timolol	1993
A 90-day study of the efficacy and side effects of 0.25% and 0.5% apraclonidine vs 0.5% timolol. Apraclonidine Primary Therapy Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:8 Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Clonidine; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Timolol	1996
A comparative evaluation of pilocarpine 1% and clonidine 0.125% versus timolol 0.5%. Indian journal of ophthalmology, 1996, Volume: 44, Issue:2 Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Blood Pressure; Clonidine; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Muscarinic Agonists; Ophthalmic Solutions; Pilocarpine; Timolol	1996
Short-term effect of apraclonidine on intraocular pressure in glaucoma patients receiving timolol and pilocarpine. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1997, Volume: 211, Issue:6 Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Clonidine; Drug Synergism; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Miotics; Ophthalmic Solutions; Pilocarpine; Prospective Studies; Timolol	1997
Comparison of the early effects of brimonidine and apraclonidine as topical ocular hypotensive agents. Archives of ophthalmology (Chicago, Ill. : 1960), 1999, Volume: 117, Issue:5 Topics: Administration, Topical; Adrenergic alpha-Agonists; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Clonidine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Fluorophotometry; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Timolol	1999
The comparative ocular hypotensive effect of apraclonidine with timolol maleate in exfoliation versus primary open-angle glaucoma patients. Eye (London, England), 1999, Volume: 13 ( Pt 3a) Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Circadian Rhythm; Clonidine; Drug Therapy, Combination; Exfoliation Syndrome; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Timolol	1999
The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation after pars plana vitrectomy with long-acting gas tamponade. Ophthalmology, 2000, Volume: 107, Issue:3 Topics: Administration, Topical; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Clonidine; Fluorocarbons; Humans; Intraocular Pressure; Ocular Hypertension; Prospective Studies; Quinoxalines; Sulfonamides; Sulfur Hexafluoride; Thiophenes; Timolol; Vitrectomy	2000
A comparative study on the effects of apraclonidine and timolol on the ophthalmic blood flow velocity waveforms. International ophthalmology, 1999, Volume: 23, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Blood Flow Velocity; Blood Pressure; Clonidine; Cross-Over Studies; Double-Blind Method; Female; Humans; Intraocular Pressure; Male; Ophthalmic Artery; Ophthalmic Solutions; Prospective Studies; Reference Values; Retinal Artery; Timolol; Ultrasonography, Doppler	1999
A prospective, long-term, randomized study of the efficacy and safety of the drug combination pilocarpine 1% with clonidine 0.06% or clonidine 0.125% versus timolol 0.25%. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2002, Volume: 18, Issue:6 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Clonidine; Drug Administration Schedule; Drug Combinations; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Longitudinal Studies; Muscarinic Agonists; Pilocarpine; Safety; Timolol; Treatment Outcome	2002
[Efficacy of prophylactic treatment of intraocular pressure spikes due to intravitreal injections]. Journal francais d'ophtalmologie, 2012, Volume: 35, Issue:8 Topics: Acetazolamide; Aged; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Bevacizumab; Brimonidine Tartrate; Chemoprevention; Clonidine; Drug Combinations; Female; Humans; Hypotonic Solutions; Intraocular Pressure; Intravitreal Injections; Macular Degeneration; Male; Ocular Hypertension; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Treatment Outcome	2012
Short-term effect of topical brinzolamide 1%-timolol 0.5% fixed combination on human central corneal thickness. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2015, Volume: 31, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Aged; Capsule Opacification; Carbonic Anhydrase Inhibitors; Clonidine; Cornea; Corneal Pachymetry; Drug Therapy, Combination; Female; Humans; Intraocular Pressure; Lasers, Solid-State; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Sulfonamides; Thiazines; Timolol	2015
Effect of Topically Applied 0.5% Apraclonidine Versus 0.5% Timolol Maleate on Intraocular Pressure of Healthy Horses. Journal of equine veterinary science, 2022, Volume: 111 Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Double-Blind Method; Female; Horse Diseases; Horses; Intraocular Pressure; Lubricant Eye Drops; Ocular Hypertension; Timolol	2022

Other Studies

44 other study(ies) available for timolol and clonidine

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
In vitro determination of the ability of drugs to bind to adrenergic receptors. Investigative ophthalmology & visual science, 1977, Volume: 16, Issue:12 Topics: Alprenolol; Animals; Ciliary Body; Clonidine; Dihydroergotoxine; Dopamine; Epinephrine; In Vitro Techniques; Iris; Isoproterenol; Male; Phentolamine; Propranolol; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Timolol	1977
[Sympathomimetic and sympatholytic drugs in the therapy of glaucoma (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1977, Volume: 171, Issue:4 Topics: Albuterol; Clonidine; Epinephrine; Glaucoma; Humans; Isoproterenol; Norepinephrine; Propranolol; Sympatholytics; Sympathomimetics; Timolol	1977
[Conservative treatment of glaucoma]. Klinika oczna, 1989, Volume: 91, Issue:6 Topics: Acetazolamide; Clonidine; Drug Evaluation; Epinephrine; Glaucoma; Humans; Intraocular Pressure; Moxisylyte; Parasympathomimetics; Timolol	1989
The role of apraclonidine hydrochloride in laser therapy for glaucoma. Transactions of the American Ophthalmological Society, 1989, Volume: 87 Topics: Acetazolamide; Adult; Aged; Animals; Clonidine; Epinephrine; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Iris; Laser Therapy; Macaca fascicularis; Male; Middle Aged; Pilocarpine; Postoperative Complications; Timolol; Trabeculectomy	1989
Replication of ciliary vasomotor effects with controlled intravascular corrosion casting. Transactions of the American Ophthalmological Society, 1989, Volume: 87 Topics: Animals; Aqueous Humor; Arterioles; Ciliary Body; Clonidine; Moxisylyte; Phenylephrine; Rabbits; Timolol; Vasomotor System	1989
Alpha noradrenergic agonists promote catalepsy in the mouse. Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Catalepsy; Clonidine; Isoproterenol; Mice; Models, Biological; Motor Activity; Phenoxybenzamine; Phenylephrine; Timolol; Yohimbine	1988
The ocular effects of xylazine in rabbits, cats, and monkeys. Journal of ocular pharmacology, 1986,Winter, Volume: 2, Issue:1 Topics: Animals; Cats; Cebus; Clonidine; Female; Intraocular Pressure; Male; Nictitating Membrane; Pupil; Rabbits; Sympathetic Nervous System; Thiazines; Timolol; Xylazine	1986
Is reduced cardiac performance the only mechanism for myocardial infarct size reduction during beta adrenergic blockade? Cardiovascular research, 1986, Volume: 20, Issue:5 Topics: Animals; Autoradiography; Cardiac Output; Cats; Clonidine; Disease Models, Animal; Heart Rate; Myocardial Infarction; Myocardium; Random Allocation; Timolol	1986
Neuropharmacological modification of central catecholamines: effects on pinealectomy-induced convulsions. Journal of pineal research, 1986, Volume: 3, Issue:1 Topics: alpha-Methyltyrosine; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; Clonidine; Desipramine; Levodopa; Male; Methyltyrosines; Parathyroid Glands; Pineal Gland; Rats; Reserpine; Seizures; Timolol	1986
Adverse drug reactions in the elderly: case studies. Geriatrics, 1984, Volume: 39, Issue:12 Topics: Acetazolamide; Aged; Anemia, Hemolytic; Bromocriptine; Captopril; Chlorpropamide; Cimetidine; Clonidine; Dienestrol; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydralazine; Lung Diseases; Male; Middle Aged; Nitrofurantoin; Pancreatitis; Papaverine; Peripheral Nervous System Diseases; Procainamide; Propranolol; Sulindac; Theophylline; Timolol	1984
Abrupt and gradual change from clonidine to beta blockers in hypertension. Acta medica Scandinavica, 1982, Volume: 211, Issue:5 Topics: Adrenergic beta-Antagonists; Atenolol; Clonidine; Drug Interactions; Female; Humans; Hypertension; Male; Middle Aged; Norepinephrine; Pilot Projects; Propanolamines; Substance Withdrawal Syndrome; Timolol	1982
[The effect of antiglaucoma drugs on the depth of the anterior chamber (I)]. Bollettino della Societa italiana di biologia sperimentale, 1982, Aug-15, Volume: 58, Issue:15 Topics: Adult; Anterior Chamber; Carbachol; Clonidine; Glaucoma; Humans; Middle Aged; Miotics; Moxisylyte; Pilocarpine; Propranolol; Quinuclidines; Timolol	1982
[Neurotransmitter control of pupillary motoricity in man]. Bollettino della Societa italiana di biologia sperimentale, 1984, Dec-30, Volume: 60, Issue:12 Topics: Clonidine; Humans; Metaproterenol; Miotics; Mydriatics; Neurotransmitter Agents; Ophthalmic Solutions; Phenylephrine; Physostigmine; Piperazines; Pupil; Time Factors; Timolol; Triazoles; Tropicamide; Tyramine	1984
Noradrenergic responses in rat hippocampus: evidence for medication by alpha and beta receptors in the in vitro slice. Brain research, 1981, Jun-09, Volume: 214, Issue:1 Topics: Animals; Clonidine; Culture Techniques; Cyclic AMP; Evoked Potentials; Hippocampus; Isoproterenol; Male; Norepinephrine; Phentolamine; Propranolol; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Thionucleotides; Timolol	1981
[Experience with timolol in consulting patients (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1980, Volume: 176, Issue:5 Topics: Clonidine; Drug Combinations; Glaucoma; Humans; Intraocular Pressure; Pilocarpine; Propanolamines; Timolol	1980
Alpha 1-adrenergic agonist-stimulated protein secretion in rat exorbital lacrimal gland acini. Experimental eye research, 1994, Volume: 58, Issue:4 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Eye Proteins; Haloperidol; Lacrimal Apparatus; Male; Methoxamine; Norepinephrine; Peroxidase; Phenylephrine; Rats; Rats, Wistar; Timolol	1994
Regulation and bioelectrical effects of cyclic adenosine monophosphate production in the ciliary epithelial bilayer. Investigative ophthalmology & visual science, 1996, Volume: 37, Issue:4 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Aqueous Humor; Ciliary Body; Clonidine; Colforsin; Cyclic AMP; Electrophysiology; Isoproterenol; Male; Membrane Potentials; Pigment Epithelium of Eye; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Timolol; Vasoactive Intestinal Peptide	1996
The effect of aqueous humor suppressants on intravitreal gas bubble duration in rabbits. American journal of ophthalmology, 1998, Volume: 125, Issue:5 Topics: Absorption; Administration, Topical; Animals; Aqueous Humor; Clonidine; Fluorocarbons; Injections; Intraocular Pressure; Rabbits; Sulfonamides; Sulfur Hexafluoride; Thiophenes; Time Factors; Timolol; Vitreous Body	1998
Glaucomatocyclitic crisis in a child. American journal of ophthalmology, 1998, Volume: 126, Issue:1 Topics: Adolescent; Clonidine; Corneal Edema; Diagnosis, Differential; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Pressure; Male; Pain; Prednisolone; Sulfonamides; Syndrome; Thiophenes; Timolol; Uveitis, Intermediate; Vision Disorders; Visual Acuity	1998
Intraocular pressure in rabbits by telemetry II: effects of animal handling and drugs. Investigative ophthalmology & visual science, 1998, Volume: 39, Issue:12 Topics: Animal Husbandry; Animals; Circadian Rhythm; Clonidine; Epinephrine; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Pilocarpine; Prostaglandins F, Synthetic; Rabbits; Sulfonamides; Telemetry; Thiophenes; Timolol; Tonometry, Ocular	1998
Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration. Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:1 Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Axons; Brimonidine Tartrate; Cell Count; Cell Survival; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Nerve Degeneration; Neuroprotective Agents; Optic Nerve; Optic Nerve Diseases; Optic Nerve Injuries; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Retinal Ganglion Cells; Timolol; Yohimbine	1999
Ultrastructural effects of topical beta-adrenergic antagonists and an alpha-adrenergic agonist on the rabbit cornea. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1999, Volume: 213, Issue:3 Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Clonidine; Cornea; Cytoplasm; Endoplasmic Reticulum; Levobunolol; Microvilli; Ophthalmic Solutions; Rabbits; Timolol	1999
Ophthaproblem. Acute angle-closure glaucoma. Canadian family physician Medecin de famille canadien, 2000, Volume: 46 Topics: Acetazolamide; Acute Disease; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Carbonic Anhydrase Inhibitors; Clonidine; Diagnosis, Differential; Glaucoma, Angle-Closure; Humans; Intraocular Pressure; Laser Therapy; Male; Middle Aged; Miotics; Ophthalmic Solutions; Pilocarpine; Timolol	2000
Oxytocin induces preservation of social recognition in male rats by activating alpha-adrenoceptors of the olfactory bulb. The European journal of neuroscience, 2000, Volume: 12, Issue:2 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Clonidine; Isoproterenol; Male; Memory; Microdialysis; Norepinephrine; Olfactory Bulb; Oxytocin; Phentolamine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Oxytocin; Social Behavior; Social Dominance; Timolol	2000
Neurotransmitter-mediated control of neuronal firing in the red nucleus of the rat: reciprocal modulation between noradrenaline and GABA. Experimental neurology, 2000, Volume: 163, Issue:1 Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Bicuculline; Clonidine; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Iontophoresis; Isoproterenol; Male; Neurons; Neurotransmitter Agents; Nipecotic Acids; Norepinephrine; Rats; Rats, Wistar; Red Nucleus; Timolol; Yohimbine	2000
Effect of SR121463, a selective non-peptide vasopressin V2 receptor antagonist, in a rabbit model of ocular hypertension. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:3 Topics: Administration, Oral; Administration, Topical; Animals; Antidiuretic Hormone Receptor Antagonists; Cell Membrane; Clonidine; Disease Models, Animal; Injections, Intravenous; Intraocular Pressure; Kidney; Male; Morpholines; Ocular Hypertension; Rabbits; Receptors, Vasopressin; Safety; Spiro Compounds; Timolol	2000
Immediate diode laser peripheral iridoplasty as treatment of acute attack of primary angle closure glaucoma: a preliminary study. Journal of glaucoma, 2001, Volume: 10, Issue:2 Topics: Acute Disease; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Clonidine; Female; Glaucoma, Angle-Closure; Humans; Intraocular Pressure; Iris; Laser Therapy; Male; Middle Aged; Miotics; Pilocarpine; Timolol; Tonometry, Ocular; Treatment Outcome	2001
Noradrenaline modulates neuronal responses to GABA in vestibular nuclei. Neuroscience, 2008, Jun-02, Volume: 153, Issue:4 Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Iontophoresis; Isoproterenol; Neural Inhibition; Neurons; Norepinephrine; Rats; Rats, Wistar; Timolol; Vestibular Nuclei; Yohimbine	2008
Recurrent serous macular detachment after topical ocular hypotensive medication. Clinical & experimental optometry, 2008, Volume: 91, Issue:6 Topics: Administration, Topical; Antihypertensive Agents; Clonidine; Drug Combinations; Drug Therapy, Combination; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Recurrence; Retinal Detachment; Serum; Sulfonamides; Thiophenes; Timolol; Tomography, Optical Coherence; Visual Acuity	2008
Noradrenergic modulation of neuronal responses to glutamate in the vestibular complex. Neuroscience letters, 2009, Oct-30, Volume: 464, Issue:3 Topics: Action Potentials; Adrenergic Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Clonidine; Glutamic Acid; Neurons; Norepinephrine; Rats; Rats, Wistar; Spinal Cord; Synaptic Transmission; Timolol; Vestibular Nuclei; Yohimbine	2009