Page last updated: 2024-08-16

timolol and brinzolamide

timolol has been researched along with brinzolamide in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.39)	18.2507
2000's	26 (36.11)	29.6817
2010's	40 (55.56)	24.3611
2020's	5 (6.94)	2.80

Authors

Authors	Studies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Silver, LH	1
Shin, D	1
March, WF; Ochsner, KI	1
Brubaker, RF; Ingram, CJ; Nau, CB; Schoff, EO	1
Friren, B; Michaud, JE	1
Herkel, U; Pfeiffer, N	1
Holló, G; Kóthy, P	2
Fong, JC; Hong, SJ; Wang, HZ; Wu, KY	1
Chen, YF; Huang, JY; Hung, PT; Shieh, JW; Wang, TH	1
Castillo, A; Fernandez-Vidal, A; Garcia-Feijoo, J; Garcia-Sanchez, J; Martinez-de-la-Casa, JM; Mendez-Hernandez, C	1
Ikeda, H; Mishima, HK; Mukai, S; Noma, H; Tsukamoto, H	1
Avila, MP; Magacho, L; Queiroz, CF; Reis, R; Santos, LC	1
Cerovski, B; Jukić, T; Popović Suić, S; Vukojević, N	1
Kiuchi, T; Motoyama, Y; Oshika, T	1
Akman, A; Akova, YA; Borazan, M; Karalezli, A	1
Bojić, L; Capkun, V; Ivanisević, M; Kovacić, Z; Rogosića, V; Stanić, R	1
Arzeno, G; Bergamini, MV; Dickerson, JE; Hua, SY; James, JE; Kaback, M; Landry, TA; Salem, C; Scoper, SV	1
Evans, RM; Mallick, S; Stewart, RH; Vold, SD; Walters, T	1
Liu, JH; Medeiros, FA; Slight, JR; Weinreb, RN	1
Martínez, A; Sánchez-Salorio, M	2
Delgado-Ortega, L; Díaz-Cerezo, S; Pinazo-Durán, MD; Soto-Alvarez, J; Vinuesa-Silva, I; Vinuesa-Silva, JM	1
Cai, JP; Cheng, JW; Wei, RL	1
Cheng, JW; Li, Y; Wei, RL	1
Croxtall, JD; Scott, LJ	1
Bozkurt, B; Holló, G; Irkec, M	1
Daito, M; Hiraoka, T; Kiuchi, T; Okamoto, F; Oshika, T	2
Harris, A; Januleviciene, I; Shoshani, Y; Siesky, B	1
Januleviciene, I	1
Crowston, JG; Goldberg, I; Jasek, MC; Stewart, JA; Stewart, WC	1
Bianchi, PE; Fusetti, M; Pallavicini, C; Pasinetti, GM; Rossi, GC; Stringa, F; Stringa, M; Tinelli, C; Vacchi, S	1
Pfeiffer, N	1
García Sánchez, J; García-Feijoó, J; Herrero-Vanrell, R; Martínez-de-la-Casa, JM; Sáenz-Francés, F; Sánchez-Pulgarín, M; Santos-Bueso, E	1
Liu, JH; Realini, T; Weinreb, RN	1
Bianchi, PE; Bordin, M; Pasinetti, GM; Rossi, GC; Sandolo, F	1
Kobayashi, H	1
Călugăru, D; Călugăru, M	2
Cojocaru, I; Pop, A; Stefan, C	1
Chen, DF; Chen, H; Cho, KS; Guo, W; Luo, G; Pang, IH; Wang, WH; Yang, Q; Yu, D	1
Di Blasio, D; Evangelista, M; Librando, A; Nebbioso, M; Pescosolido, N	1
Arnold, JJ; Challa, P; Chapleau, CA; Gorman, GS; Hansen, MS; Hunsinger, RN; Inoue, T; Pozzo-Miller, L; Rao, V; Spellen, S; Stamer, WD	1
Chung, IY; Han, YS; Kim, GN; Park, JM; Seo, SW; Yoo, JM	1
Akçali, G; Bozkurt, KT; Güney, E; Sezgin Akçay, Bİ; Unlü, C	1
Iotova, V; Kiryazov, K; Stefova, M	1
Marques, A	1
Alezzandrini, A; Alfaro, R; Hubatsch, D	1
Alagoz, G; Altun, G; Celik, E; Turkoglu, EB	1
Mansouri, K; Medeiros, FA; Weinreb, RN	1
Busse, C; Newton, JR; Stavinohova, R	1
Elsaied, HM; Fouad, PH; Galose, MS; Macky, TA	1
Fukuda, M; Sasaki, H; Shibata, N; Shibata, S; Shibata, T; Sugiyama, K; Takeda, N	1
Konstantinidis, A; Kozobolis, V; Labiris, G; Panos, GD	1
DeWitt, PE; Kahook, MY; Kroehl, ME; Seibold, LK	1
Fagan, X; Harper, CA; Ong, D	1
Adachi, M; Aihara, M; Fukuchi, T; Matsuo, H; Sasaki, N; Togano, T	1
Akyol, N; Imamoglu, HI; Kalkisim, A; Kola, M; Turk, A	1
Balsak, S; Erdem, S; Fuat Alakus, M; Kaydu, A; Ozkurt, ZG	1
Holopainen, JM; Pisella, PJ; Rantamäki, AH; Robciuc, A; Ruokonen, SK; Wiedmer, SK; Witos, J	1
Ma, F; Ma, H; Ma, J; Shang, Q; Su, J; Wang, X; Yu, J; Zhang, T	1
Ali, J; Baboota, S; Khan, S; Shrivastava, N	1
Hayashi, K; Manabe, SI; Sato, T; Yoshida, M	1
El Abass, SA; Elmansi, HM; Ibrahim, FA	1
Boevé, MH; de Gee, R; Djajadiningrat-Laanen, SC; Elders, DJ; Koele, LE; Slenter, IJM; Vermeer, LW	1
Jin, SW; Joh, HJ	1
Chen, O; Jamieson, MPH; Ling, D; Perera, N; Pinnuck, BC; Williams, M	1
Aapola, U; Nukareddy, P; Uusitalo, H; Välimäki, J	1
Bleskina, MY; Kolotilina, NE; Lisitsyn, AB; Loskutov, IA; Poromov, AA	1
Adachi, M; Aihara, M; Asato, R; Hamada, N; Hara, T; Mizoue, S; Muramatsu, T; Naito, T; Ohkubo, S; Sakata, R; Yoshikawa, K	1

Reviews

8 review(s) available for timolol and brinzolamide

Article	Year
[Development of conjunctival hyperemia with the use of a fixed combination of latanoprost/timolol: systematic review and meta-analysis of clinical trials]. Archivos de la Sociedad Espanola de Oftalmologia, 2009, Volume: 84, Issue:4 Topics: Aged; Brimonidine Tartrate; Clinical Trials as Topic; Cloprostenol; Conjunctival Diseases; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Glaucoma; Humans; Hyperemia; Latanoprost; Middle Aged; Ocular Hypertension; Odds Ratio; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Timolol; Travoprost	2009
Meta-analysis of medical intervention for normal tension glaucoma. Ophthalmology, 2009, Volume: 116, Issue:7 Topics: Aged; Amides; Antihypertensive Agents; Betaxolol; Bimatoprost; Brimonidine Tartrate; Cloprostenol; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Quinoxalines; Randomized Controlled Trials as Topic; Sulfonamides; Thiazines; Thiophenes; Timolol; Tonometry, Ocular; Travoprost	2009
Systematic review of intraocular pressure-lowering effects of adjunctive medications added to latanoprost. Ophthalmic research, 2009, Volume: 42, Issue:2 Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Databases, Factual; Drug Therapy, Combination; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Optic Nerve Diseases; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Thiophenes; Timolol	2009
Brinzolamide/timolol fixed combination: a new ocular suspension for the treatment of open-angle glaucoma and ocular hypertension. Expert opinion on pharmacotherapy, 2009, Volume: 10, Issue:12 Topics: Administration, Topical; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Drug Combinations; Glaucoma, Open-Angle; Humans; Ocular Hypertension; Ophthalmic Solutions; Sulfonamides; Suspensions; Thiazines; Timolol	2009
Brinzolamide 1%/timolol 0.5%: safety and efficacy of a new fixed-combination IOP-lowering product for glaucoma. Current medical research and opinion, 2010, Volume: 26, Issue:11 Topics: Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Glaucoma; Humans; Intraocular Pressure; Sulfonamides; Thiazines; Timolol; Treatment Outcome	2010
[Azarga, a new and useful fixed combination in glaucoma treatment]. Oftalmologia (Bucharest, Romania : 1990), 2011, Volume: 55, Issue:3 Topics: Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Drug Combinations; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ophthalmic Solutions; Randomized Controlled Trials as Topic; Sulfonamides; Thiazines; Thiophenes; Timolol; Treatment Outcome; Vision, Ocular	2011
[The latest developments in glaucoma therapy using fixed combination products]. Oftalmologia (Bucharest, Romania : 1990), 2011, Volume: 55, Issue:3 Topics: Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate, Timolol Maleate Drug Combination; Carbonic Anhydrase Inhibitors; Cloprostenol; Drug Combinations; Drug Therapy, Combination; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Thiophenes; Timolol; Travoprost; Treatment Outcome	2011
[Fixed combination of topical prostaglandin analogue in glaucoma treatment]. Oftalmologia (Bucharest, Romania : 1990), 2011, Volume: 55, Issue:3 Topics: Amides; Antihypertensive Agents; Bimatoprost; Carbonic Anhydrase Inhibitors; Cloprostenol; Drug Combinations; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Optic Nerve; Prostaglandins F, Synthetic; Prostaglandins, Synthetic; Sulfonamides; Thiazines; Timolol; Travoprost; Treatment Outcome; Visual Fields	2011

Trials

38 trial(s) available for timolol and brinzolamide

Article	Year
Clinical efficacy and safety of brinzolamide (Azopt), a new topical carbonic anhydrase inhibitor for primary open-angle glaucoma and ocular hypertension. Brinzolamide Primary Therapy Study Group. American journal of ophthalmology, 1998, Volume: 126, Issue:3 Topics: Administration, Topical; Adrenergic beta-Antagonists; Aged; Carbonic Anhydrase Inhibitors; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Safety; Sulfonamides; Thiazines; Thiophenes; Timolol; Treatment Outcome	1998
Adjunctive therapy with brinzolamide 1% ophthalmic suspension (Azopt) in patients with open-angle glaucoma or ocular hypertension maintained on timolol therapy. Survey of ophthalmology, 2000, Volume: 44 Suppl 2 Topics: Adrenergic beta-Antagonists; Adult; Aged; Carbonic Anhydrase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Safety; Sulfonamides; Suspensions; Thiazines; Timolol; Treatment Outcome	2000
The long-term safety and efficacy of brinzolamide 1.0% (azopt) in patients with primary open-angle glaucoma or ocular hypertension. The Brinzolamide Long-Term Therapy Study Group. American journal of ophthalmology, 2000, Volume: 129, Issue:2 Topics: Administration, Topical; Adrenergic beta-Antagonists; Aged; Carbonic Anhydrase Inhibitors; Double-Blind Method; Drug Evaluation; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Safety; Sulfonamides; Thiazines; Timolol	2000
Comparison of the efficacy of betaxolol-brinzolamide and timolol-dorzolamide as suppressors of aqueous humor flow in human subjects. Ophthalmology, 2000, Volume: 107, Issue:2 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aqueous Humor; Betaxolol; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Female; Fluorophotometry; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Safety; Sulfonamides; Thiazines; Thiophenes; Timolol; Tonometry, Ocular	2000
Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension. American journal of ophthalmology, 2001, Volume: 132, Issue:2 Topics: Administration, Topical; Adrenergic beta-Antagonists; Aged; Carbonic Anhydrase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Safety; Sulfonamides; Thiazines; Thiophenes; Timolol; Treatment Outcome	2001
Does glaucoma medication influence the diameter of the retinal arteriole in the human eye? (A pilot study using the retinal vessel analyser). Acta physiologica Hungarica, 2001, Volume: 88, Issue:3-4 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Arterioles; Betaxolol; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Glaucoma; Humans; Latanoprost; Middle Aged; Ophthalmology; Pilot Projects; Prostaglandins F, Synthetic; Quinoxalines; Retinal Artery; Sulfonamides; Thiazines; Timolol	2001
Ocular hypotensive effect and safety of brinzolamide ophthalmic solution in open angle glaucoma patients. Journal of the Formosan Medical Association = Taiwan yi zhi, 2004, Volume: 103, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Carbonic Anhydrase Inhibitors; Consumer Product Safety; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Sulfonamides; Thiazines; Timolol	2004
Concomitant administration of travoprost and brinzolamide versus fixed latanoprost/timolol combined therapy: three-month comparison of efficacy and safety. Current medical research and opinion, 2004, Volume: 20, Issue:9 Topics: Cloprostenol; Drug Combinations; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prostaglandins F, Synthetic; Sulfonamides; Thiazines; Timolol; Travoprost	2004
The efficacy and ocular discomfort of substituting brinzolamide for dorzolamide in combination therapy with latanoprost, timolol, and dorzolamide. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2005, Volume: 21, Issue:5 Topics: Aged; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Sulfonamides; Thiazines; Thiophenes; Timolol; Vision, Ocular	2005
A randomized, investigator-masked, 4-week study comparing timolol maleate 0.5%, brinzolamide 1%, and brimonidine tartrate 0.2% as adjunctive therapies to travoprost 0.004% in adults with primary open-angle glaucoma or ocular hypertension. Clinical therapeutics, 2006, Volume: 28, Issue:4 Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Cloprostenol; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Quinoxalines; Sulfonamides; Thiazines; Timolol; Travoprost	2006
[Combined therapy in glaucoma treatment: travoprost 0.004% and brinzolamid]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2006, Volume: 60, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Carbonic Anhydrase Inhibitors; Cloprostenol; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Sulfonamides; Thiazines; Timolol; Travoprost	2006
Influence of ocular hypotensive eyedrops on intraocular pressure fluctuation with postural change in eyes with normal-tension glaucoma. American journal of ophthalmology, 2007, Volume: 143, Issue:4 Topics: Adult; Aged; Antihypertensive Agents; Cross-Over Studies; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ophthalmic Solutions; Posture; Prospective Studies; Prostaglandins F, Synthetic; Single-Blind Method; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular; Visual Field Tests	2007
Effect of antiglaucoma agents on postoperative intraocular pressure after cataract surgery with Viscoat. Journal of cataract and refractive surgery, 2007, Volume: 33, Issue:11 Topics: Acetazolamide; Acetylcholine; Administration, Topical; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Chondroitin; Chondroitin Sulfates; Double-Blind Method; Drug Combinations; Female; Humans; Hyaluronic Acid; Intraocular Pressure; Lens Implantation, Intraocular; Male; Middle Aged; Ocular Hypertension; Phacoemulsification; Postoperative Complications; Prospective Studies; Quinoxalines; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular	2007
[Additive therapy with carboanhydrase inhibitors for open angle glaucoma previously treated with timolol 0.5% drops]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2007, Volume: 61, Issue:4 Topics: Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Sulfonamides; Thiazines; Thiophenes; Timolol	2007
Intraocular pressure reduction with travoprost/timolol fixed combination, with and without adjunctive brinzolamide, in glaucoma. Current medical research and opinion, 2008, Volume: 24, Issue:6 Topics: Aged; Cloprostenol; Drug Combinations; Drug Therapy, Combination; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Sulfonamides; Thiazines; Timolol; Travoprost	2008
Intraocular pressure-lowering efficacy of brinzolamide 1%/timolol 0.5% fixed combination compared with brinzolamide 1% and timolol 0.5%. Ophthalmology, 2008, Volume: 115, Issue:10 Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Carbonic Anhydrase Inhibitors; Double-Blind Method; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular; Visual Acuity	2008
A one-week comfort study of BID-dosed brinzolamide 1%/timolol 0.5% ophthalmic suspension fixed combination compared to BID-dosed dorzolamide 2%/timolol 0.5% ophthalmic solution in patients with open-angle glaucoma or ocular hypertension. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2008, Volume: 24, Issue:6 Topics: Adult; Aged; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Sulfonamides; Thiazines; Thiophenes; Timolol	2008
Comparing diurnal and nocturnal effects of brinzolamide and timolol on intraocular pressure in patients receiving latanoprost monotherapy. Ophthalmology, 2009, Volume: 116, Issue:3 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Carbonic Anhydrase Inhibitors; Circadian Rhythm; Cross-Over Studies; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Posture; Prospective Studies; Prostaglandins F, Synthetic; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular	2009
A comparison of the long-term effects of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5%, on retrobulbar hemodynamics and intraocular pressure in open-angle glaucoma patients. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2009, Volume: 25, Issue:3 Topics: Administration, Topical; Aged; Antihypertensive Agents; Blood Pressure; Carbonic Anhydrase Inhibitors; Drug Administration Schedule; Drug Combinations; Female; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Prospective Studies; Regional Blood Flow; Sulfonamides; Thiazines; Thiophenes; Timolol; Ultrasonography, Doppler, Color	2009
Predictors for visual field progression and the effects of treatment with dorzolamide 2% or brinzolamide 1% each added to timolol 0.5% in primary open-angle glaucoma. Acta ophthalmologica, 2010, Volume: 88, Issue:5 Topics: Aged; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Carbonic Anhydrase Inhibitors; Ciliary Arteries; Disease Progression; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Artery; Proportional Hazards Models; Prospective Studies; Retinal Artery; Risk Factors; Sulfonamides; Thiazines; Thiophenes; Timolol; Tonometry, Ocular; Ultrasonography, Doppler, Color; Vision Disorders; Visual Fields	2010
Intraocular pressure-lowering efficacy of brinzolamide when added to travoprost/timolol fixed combination as adjunctive therapy. Journal of glaucoma, 2012, Volume: 21, Issue:1 Topics: Aged; Antihypertensive Agents; Cloprostenol; Double-Blind Method; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular; Travoprost; Treatment Outcome; Visual Acuity	2012
Timolol versus brinzolamide added to travoprost in glaucoma or ocular hypertension. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2011, Volume: 249, Issue:7 Topics: Aged; Antihypertensive Agents; Cloprostenol; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular; Travoprost; Treatment Outcome	2011
[Comparative study of the pressure lowering efficacy and variations in the ocular pulse amplitude between fixed combinations of dorzolamide/timolol and brinzolamide/timolol]. Archivos de la Sociedad Espanola de Oftalmologia, 2011, Volume: 86, Issue:5 Topics: Adult; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Cross-Sectional Studies; Drug Combinations; Female; Humans; Intraocular Pressure; Male; Pulse; Sulfonamides; Thiazines; Thiophenes; Timolol; Young Adult	2011
From dorzolamide 2%/timolol 0.5% to brinzolamide 1%/timolol 0.5% fixed combination: a 6-month, multicenter, open-label tolerability switch study. Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:16 Topics: Aged; Antihypertensive Agents; Diagnostic Techniques, Ophthalmological; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Quality of Life; Sulfonamides; Surveys and Questionnaires; Thiazines; Thiophenes; Timolol	2011
Efficacy of single glaucoma drug in combined timolol XE, latanoprost and brinzolamide therapy: a discontinuation study. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:3 Topics: Adult; Aged; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Prostaglandins F, Synthetic; Sulfonamides; Thiazines; Timolol	2012
Fixed topical combinations in glaucomatous patients and ocular discomfort. Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:13 Topics: Administration, Ophthalmic; Aged; Antihypertensive Agents; Benzalkonium Compounds; Carbonic Anhydrase Inhibitors; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Male; Middle Aged; Preservatives, Pharmaceutical; Prospective Studies; Single-Blind Method; Sulfonamides; Suspensions; Thiazines; Thiophenes; Time Factors; Timolol	2012
The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2013, Volume: 29, Issue:10 Topics: Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Patient Preference; Sulfonamides; Thiazines; Thiophenes; Timolol; Treatment Outcome	2013
Efficacy and tolerability of fixed-combination brinzolamide/timolol in Latin American patients with open-angle glaucoma or ocular hypertension previously on brimonidine/timolol fixed combination. Advances in therapy, 2014, Volume: 31, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latin America; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Research Design; Sulfonamides; Thiazines; Timolol; United States	2014
Short-term effect of topical brinzolamide 1%-timolol 0.5% fixed combination on human central corneal thickness. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2015, Volume: 31, Issue:4 Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Aged; Capsule Opacification; Carbonic Anhydrase Inhibitors; Clonidine; Cornea; Corneal Pachymetry; Drug Therapy, Combination; Female; Humans; Intraocular Pressure; Lasers, Solid-State; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Sulfonamides; Thiazines; Timolol	2015
Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor. Clinical & experimental ophthalmology, 2015, Volume: 43, Issue:9 Topics: Administration, Topical; Adult; Aged; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Circadian Rhythm; Contact Lenses; Cross-Over Studies; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Monitoring, Ambulatory; Ophthalmic Solutions; Prospective Studies; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular; Young Adult	2015
Brinzolamide/timolol versus dorzolamide/timolol fixed combinations: A hospital-based, prospective, randomized study. Indian journal of ophthalmology, 2016, Volume: 64, Issue:2 Topics: Administration, Topical; Adolescent; Adult; Aged; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Drug Combinations; Egypt; Female; Glaucoma, Open-Angle; Hospitals, University; Humans; Intraocular Pressure; Low Tension Glaucoma; Male; Middle Aged; Ophthalmic Solutions; Prospective Studies; Sulfonamides; Thiazines; Thiophenes; Timolol; Tonometry, Ocular	2016
Comparison of dorzolamide/timolol vs brinzolamide/brimonidine fixed combination therapy in the management of primary open-angle glaucoma. European journal of ophthalmology, 2017, Mar-10, Volume: 27, Issue:2 Topics: Aged; Antihypertensive Agents; Double-Blind Method; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Sulfonamides; Thiazines; Thiophenes; Timolol; Tonometry, Ocular; Treatment Outcome	2017
The 24-Hour Effects of Brinzolamide/Brimonidine Fixed Combination and Timolol on Intraocular Pressure and Ocular Perfusion Pressure. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2017, Volume: 33, Issue:3 Topics: Aged; Blood Pressure; Brimonidine Tartrate; Drug Combinations; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Ocular Hypertension; Prospective Studies; Sulfonamides; Thiazines; Timolol	2017
Additive effects and safety of fixed combination therapy with 1% brinzolamide and 0.5% timolol versus 1% dorzolamide and 0.5% timolol in prostaglandin-treated glaucoma patients. Acta ophthalmologica, 2017, Volume: 95, Issue:8 Topics: Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Follow-Up Studies; Glaucoma, Open-Angle; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Prostaglandins, Synthetic; Sulfonamides; Thiazines; Thiophenes; Time Factors; Timolol; Tonometry, Ocular; Treatment Outcome	2017
Evaluation of the effects on choroidal thickness of bimatoprost 0.03% versus a brinzolamide 1.0%/timolol maleate 0.5% fixed combination. Cutaneous and ocular toxicology, 2017, Volume: 36, Issue:4 Topics: Adult; Aged; Antihypertensive Agents; Bimatoprost; Choroid; Drug Combinations; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Middle Aged; Single-Blind Method; Sulfonamides; Thiazines; Timolol; Tomography, Optical Coherence	2017
Brimonidine-timolol versus brinzolamide-timolol for treatment of elevated intraocular pressure after phacoemulsification surgery. International ophthalmology, 2018, Volume: 38, Issue:4 Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Phacoemulsification; Postoperative Complications; Prospective Studies; Sulfonamides; Thiazines; Timolol	2018
Effect of Topical Hypotensive Medications for Preventing Intraocular Pressure Increase after Cataract Surgery in Eyes with Glaucoma. American journal of ophthalmology, 2019, Volume: 205 Topics: Aged; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Cataract; Cataract Extraction; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Ocular Hypertension; Ophthalmic Solutions; Postoperative Complications; Prospective Studies; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular; Travoprost; Treatment Outcome	2019
The effects of topical dorzolamide 2% and brinzolamide 1%, either alone or combined with timolol 0.5%, on intraocular pressure, pupil diameter, and heart rate in healthy cats. Veterinary ophthalmology, 2020, Volume: 23, Issue:1 Topics: Animals; Cats; Cross-Over Studies; Double-Blind Method; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Female; Heart Rate; Intraocular Pressure; Male; Ophthalmic Solutions; Pupil; Sulfonamides; Thiazines; Thiophenes; Timolol	2020

Other Studies

26 other study(ies) available for timolol and brinzolamide

Article	Year
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
[Innovative glaucoma therapy. Glaucoma therapy with topical carbonic anhydrase inhibitors]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2001, Volume: 98, Issue:10 Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Rabbits; Sulfonamides; Thiazines; Thiophenes; Time Factors; Timolol	2001
Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:3 Topics: Animals; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Calcium; Carteolol; Cell Death; Dose-Response Relationship, Drug; Epinephrine; Glaucoma; Glutamic Acid; Latanoprost; Mice; Neuroblastoma; Neurons; Neuroprotective Agents; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Thiophenes; Timolol; Tumor Cells, Cultured	2003
Brinzolamide/timolol: in open-angle glaucoma and ocular hypertension. Drugs & aging, 2009, Volume: 26, Issue:5 Topics: Adrenergic beta-Antagonists; Carbonic Anhydrase Inhibitors; Clinical Trials as Topic; Drug Combinations; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Sulfonamides; Thiazines; Timolol	2009
[Time course of changes in contrast sensitivity function after application of antiglaucomatous eyedrops]. Nippon Ganka Gakkai zasshi, 2009, Volume: 113, Issue:12 Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Contrast Sensitivity; Female; Gels; Humans; Male; Middle Aged; Ophthalmic Solutions; Sulfonamides; Thiazines; Time Factors; Timolol; Vision, Ocular; Young Adult	2009
Predictors for visual field progression. Acta ophthalmologica, 2010, Volume: 88, Issue:5 Topics: Antihypertensive Agents; Blood Flow Velocity; Disease Progression; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Optic Disk; Regional Blood Flow; Sulfonamides; Thiazines; Thiophenes; Timolol; Vision Disorders; Visual Fields	2010
Contrast sensitivity and optical quality of the eye after instillation of timolol maleate gel-forming solution and brinzolamide ophthalmic suspension. Ophthalmology, 2010, Volume: 117, Issue:11 Topics: Adult; Antihypertensive Agents; Contrast Sensitivity; Cornea; Female; Humans; Light; Male; Ophthalmic Solutions; Prospective Studies; Scattering, Radiation; Sulfonamides; Thiazines; Time Factors; Timolol	2010
Signs and symptoms of ocular surface status in glaucoma patients switched from timolol 0.5% to brinzolamide 1%/timolol 0.5% fixed combination: a 6-month efficacy and tolerability, multicenter, open-label prospective study. Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:5 Topics: Adrenergic beta-Antagonists; Aged; Carbonic Anhydrase Inhibitors; Drug Combinations; Epithelium, Corneal; Female; Glaucoma; Humans; Male; Middle Aged; Prospective Studies; Sulfonamides; Thiazines; Timolol	2011
Asymmetry of 24-hour intraocular pressure reduction by topical ocular hypotensive medications in fellow eyes. Ophthalmology, 2011, Volume: 118, Issue:10 Topics: Administration, Topical; Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Cloprostenol; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Posture; Prostaglandins F, Synthetic; Quinoxalines; Retrospective Studies; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular; Travoprost	2011
Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma. Investigative ophthalmology & visual science, 2012, Jun-20, Volume: 53, Issue:7 Topics: Animals; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Drug Evaluation, Preclinical; Feasibility Studies; Intraocular Pressure; Latanoprost; Mice; Mice, Inbred C57BL; Microspheres; Muscarinic Agonists; Ocular Hypertension; Optic Nerve; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Retinal Ganglion Cells; Sulfonamides; Thiazines; Timolol; Tomography, Optical Coherence	2012
The effect of Rho-associated kinase inhibition on the ocular penetration of timolol maleate. Investigative ophthalmology & visual science, 2013, Feb-07, Volume: 54, Issue:2 Topics: Adrenergic beta-Antagonists; Amides; Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Chromatography, Liquid; Conjunctiva; Cornea; Diffusion Chambers, Culture; Enzyme Inhibitors; Iris; Lens, Crystalline; Male; Microscopy, Confocal; Microscopy, Electron, Scanning; Platelet Endothelial Cell Adhesion Molecule-1; Pyridines; Rabbits; rho-Associated Kinases; Sotalol; Sulfonamides; Swine; Tandem Mass Spectrometry; Thiazines; Timolol; Tissue Distribution	2013
Effect of Dorzolamide/Timolol or Brinzolamide/Timolol prophylaxis on intravitreal anti-VEGF injection-induced intraocular hypertension. Seminars in ophthalmology, 2013, Volume: 28, Issue:2 Topics: Administration, Topical; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Bevacizumab; Drug Therapy, Combination; Female; Humans; Intraocular Pressure; Intravitreal Injections; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Ranibizumab; Retinal Diseases; Sulfonamides; Thiazines; Thiophenes; Timolol; Tonometry, Ocular; Vascular Endothelial Growth Factor A	2013
Can ophthalmic drops cause central nervous system depression and cardiogenic shock in infants? Pediatric emergency care, 2013, Volume: 29, Issue:11 Topics: Absorption; Administration, Ophthalmic; Apnea; Bradycardia; Brimonidine Tartrate; Consciousness Disorders; Dose-Response Relationship, Drug; Drug Combinations; Emergencies; Female; Glaucoma; Humans; Hypothermia; Infant; Muscle Hypotonia; Nasal Mucosa; Ophthalmic Solutions; Quinoxalines; Shock, Cardiogenic; Sulfonamides; Thiazines; Timolol	2013
Managing advanced unilateral pseudoexfoliative glaucoma. BMJ case reports, 2014, May-21, Volume: 2014 Topics: Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Exfoliation Syndrome; Glaucoma, Open-Angle; Humans; Hypertrichosis; Intraocular Pressure; Iris Diseases; Latanoprost; Male; Middle Aged; Pigmentation Disorders; Prostaglandins F, Synthetic; Sulfonamides; Thiazines; Timolol; Trabeculectomy	2014
The effect of prophylactic topical carbonic anhydrase inhibitors in canine primary closed-angle glaucoma. The Journal of small animal practice, 2015, Volume: 56, Issue:11 Topics: Administration, Ophthalmic; Animals; Carbonic Anhydrase Inhibitors; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Glaucoma, Angle-Closure; Intraocular Pressure; Male; Retrospective Studies; Sulfonamides; Thiazines; Thiophenes; Timolol	2015
In vitro and in vivo corneal effects of latanoprost combined with brimonidine, timolol, dorzolamide, or brinzolamide. European journal of pharmacology, 2016, Sep-15, Volume: 787 Topics: Animals; Brimonidine Tartrate; Cell Survival; Electric Impedance; Epithelium, Corneal; Intraocular Pressure; Latanoprost; Male; Ophthalmic Solutions; Prostaglandins F, Synthetic; Rabbits; Safety; Sulfonamides; Thiazines; Thiophenes; Timolol	2016
Clinical case of influenza A with outer retinal maculopathy. Clinical & experimental ophthalmology, 2017, Volume: 45, Issue:7 Topics: Antihypertensive Agents; Drug Therapy, Combination; Eye Infections, Viral; Fluorescein Angiography; Glucocorticoids; Humans; Influenza A virus; Influenza, Human; Intraocular Pressure; Male; Middle Aged; Nasopharynx; Retinal Diseases; Sulfonamides; Thiazines; Timolol; Tomography, Optical Coherence; Visual Acuity	2017
Pure Glaucoma Drugs Are Toxic to Immortalized Human Corneal Epithelial Cells, but They Do Not Destabilize Lipid Membranes. Cornea, 2017, Volume: 36, Issue:10 Topics: Antihypertensive Agents; Apoptosis; Brimonidine Tartrate; Cell Line; Cell Membrane; Cell Survival; Electrophoresis, Capillary; Epithelium, Corneal; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Liposomes; Membrane Lipids; Ocular Hypertension; Pilocarpine; Prostaglandins F, Synthetic; Sulfonamides; Thiazines; Timolol	2017
Changes in Ocular Hemodynamics after Carotid Artery Angioplasty and Stenting (CAAS) in Patients with Different Severity of Ocular Ischemic Syndrome. Current eye research, 2018, Volume: 43, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon; Blood Flow Velocity; Carbonic Anhydrase Inhibitors; Carotid Artery, Internal; Carotid Stenosis; Drug Therapy, Combination; Eye; Female; Humans; Intraocular Pressure; Iris; Ischemia; Laser Coagulation; Male; Neovascularization, Pathologic; Ophthalmic Artery; Prospective Studies; Retinal Vessels; Stents; Sulfonamides; Thiazines; Timolol; Ultrasonography, Doppler, Color; Visual Acuity	2018
Fabrication and Characterization of Timolol Maleate and Brinzolamide Loaded Nanostructured Lipid Carrier System for Ocular Drug Delivery. Current drug delivery, 2018, Volume: 15, Issue:6 Topics: Animals; Drug Carriers; Drug Delivery Systems; Glaucoma; Goats; Kinetics; Lipids; Nanostructures; Particle Size; Sulfonamides; Thiazines; Timolol	2018
A versatile HPLC method with an isocratic single mobile phase system for simultaneous determination of anti-glaucoma formulations containing timolol. Annales pharmaceutiques francaises, 2019, Volume: 77, Issue:4 Topics: Adrenergic beta-Antagonists; Brimonidine Tartrate; Chromatography, High Pressure Liquid; Drug Combinations; Drug Compounding; Glaucoma; Limit of Detection; Ophthalmic Solutions; Reference Standards; Reproducibility of Results; Sulfonamides; Thiazines; Thiophenes; Timolol	2019
Comparison of different combinations of maximum medical therapy for lowering intraocular pressure in primary open angle glaucoma: 12-month retrospective consecutive case series. Japanese journal of ophthalmology, 2019, Volume: 63, Issue:4 Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Prostaglandins F; Retrospective Studies; Sulfonamides; Thiazines; Time Factors; Timolol; Treatment Outcome	2019
Prescribing Trends of Topical Glaucoma Medications in Australia From 2001 to 2017. Journal of glaucoma, 2020, Volume: 29, Issue:3 Topics: Administration, Ophthalmic; Adrenergic Agonists; Antihypertensive Agents; Australia; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization; Glaucoma, Open-Angle; Health Services Research; Health Surveys; Humans; Intraocular Pressure; Ophthalmic Solutions; Practice Patterns, Physicians'; Sulfonamides; Thiazines; Timolol	2020
Intraluminal deposits: A rare cause of glaucoma drainage implant total obstruction. European journal of ophthalmology, 2023, Volume: 33, Issue:1 Topics: Glaucoma; Glaucoma Drainage Implants; Humans; Intraocular Pressure; Timolol	2023
[Efficacy and safety of a fixed combination drug Brinzolol Duo in the treatment of patients with primary open-angle glaucoma]. Vestnik oftalmologii, 2022, Volume: 138, Issue:6 Topics: Antihypertensive Agents; Drug Combinations; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Timolol; Treatment Outcome	2022
Additive effects of brimonidine tartrate 0.1%/brinzolamide 1% fixed-dose combination in prostaglandin analog-treated Japanese glaucoma patients. Japanese journal of ophthalmology, 2023, Volume: 67, Issue:6 Topics: Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; East Asian People; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Prospective Studies; Prostaglandins, Synthetic; Timolol	2023