timolol has been researched along with atenolol in 122 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 57 (46.72) | 18.7374 |
1990's | 15 (12.30) | 18.2507 |
2000's | 27 (22.13) | 29.6817 |
2010's | 17 (13.93) | 24.3611 |
2020's | 6 (4.92) | 2.80 |
Authors | Studies |
---|---|
Baldwin, JJ; Christy, ME; Denny, GH; Freedman, MB; Gross, DM; Habecker, CN; Lyle, PA; Ponticello, GS; Sweet, CS; Varga, SL | 1 |
Alexander, J; Cargill, R; Michelson, SR; Schwam, H | 1 |
Carrupt, PA; el Tayar, N; Testa, B; Van de Waterbeemd, H | 1 |
Baldwin, JJ; Denny, GH; Freedman, MB; Gross, DM; Hirschmann, R; Ponticello, GS; Sweet, CS | 1 |
Carrupt, PA; Gaillard, P; Schambel, P; Testa, B | 1 |
Topliss, JG; Yoshida, F | 1 |
Faller, B; Wohnsland, F | 1 |
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
Baker, JG | 1 |
Caron, G; Ermondi, G | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Abraham, MH; Acree, WE; Ibrahim, A | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Bard, B; Carrupt, PA; Martel, S | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Campillo, NE; Guerra, A; Páez, JA | 1 |
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Bellman, K; Knegtel, RM; Settimo, L | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Andring, JT; Bua, S; Carta, F; Ceruso, M; Filippi, L; Gratteri, P; Lanzi, C; Lomelino, CL; Masini, E; Matucci, R; McKenna, R; Nocentini, A; Pecori, R; Selleri, S; Sgambellone, S; Supuran, CT | 1 |
Chang, Q; Chen, Z; Hu, G; Hu, L; Li, Q; Long, J | 1 |
Dickerson, DD; Fulmor, IE; Goldberg, ME; Lee, RJ | 1 |
Wilcox, RG | 1 |
Bühler, FR; Burkart, F; Marbet, G; Patel, U | 1 |
Kiechel, JR; Meier, J | 1 |
Bellucci, R; Bonomi, L; Massa, F; Noya, E; Perfetti, S | 1 |
Brown, B; Buckley, M; Darragh, A; Fitzgerald, D; Foley, JE; O'Kelly, D; Tormey, W; Vukovich, RA; Willard, DA | 1 |
Boger, WP | 1 |
Collignon-Brach, J; Weekers, R | 1 |
Bousser, MG; Massiou, H | 1 |
Chien, DS; Hayakawa, E; Inagaki, K; Lee, VH; Wang, W; Yamamoto, A | 1 |
Hayakawa, E; Kato, Y; Lee, VH; Nishiura, A; Yamamoto, A | 1 |
Cherchi, A; Sau, F; Seguro, C | 1 |
Armour, JA; Boudreau, G; Cardinal, R; Watson-Wright, W | 1 |
Ashton, P; Lee, VH; Podder, SK | 1 |
Bundgaard, H; Buur, A; Lee, VH; Wang, W | 1 |
Borkowski, KR; Daniel, EE; Kwan, CY | 1 |
Barradas, MA; Dandona, P; Khokher, MA; Mikhailidis, DP; Turaihi, K | 1 |
Dolva, LO; Gullestad, L; Kjekshus, J; Larsen, S; Nordby, G; Skaaraas, K | 1 |
From, RP; Mehta, MP; Pathak, D | 1 |
Baron, DN; Green, RJ; Khan, FA | 1 |
Jackson, PR; Lennard, MS; Lewis, RV; Ramsay, LE; Tucker, GT; Woods, HF | 1 |
Fletcher, GF | 1 |
Fishbein, L; Jackson, CD | 1 |
Lennard, MS; Silas, JH; Tucker, GT; Woods, HF | 1 |
Srivastava, KC | 1 |
Proegler, M; Schneider, H | 1 |
Kato, T; Nagamine, F; Nakasone, J; Noguchi, K; Sakanashi, M | 1 |
Reid, JL; Struthers, AD; Whyte, KF | 1 |
DeLoach, G; Satumtira, N; Yorio, T | 1 |
Vidt, DG | 1 |
Johansson, SR; McCall, M; Vedin, JA; Wilhelmsson, C | 1 |
Innemee, HC; Ros, FE; van Zwieten, PA | 1 |
Ohrström, A; Pandolfi, M | 1 |
Colasanti, BK; Trotter, RR | 1 |
Frishman, WH; Koch-Weser, J | 1 |
Hedges, A; Kilfeather, S; Lima, DR; Turner, P | 1 |
Hampton, JR | 1 |
Ohrström, A | 1 |
Hjalmarson, A | 1 |
Jounela, AJ; Juustila, HJ; Lilja, M; Paalzow, L | 1 |
Patel, L; Turner, P; Weerasuriya, K | 1 |
Iskandrian, AS; Kotler, MN; Segal, BL | 1 |
Carr, SS; Draper, AJ; Lamaa, M; Redfern, PH | 1 |
Lund-Johansen, P | 1 |
Ermakova, VN | 1 |
Teräväinen, H | 1 |
Jackson, EA; Sullman, SA | 1 |
Chung, DC; Laschuk, MJ | 1 |
Friedewald, WT; Frishman, WH; Furberg, CD | 1 |
Peele, ME; Shulkin, BL; Utiger, RD | 1 |
McGoon, MD; Vlietstra, RE | 1 |
Abed, J; Donaldson, R; Nashat, F; Taggart, P | 1 |
Churchill, MC; Churchill, PC; McDonald, FD | 1 |
Crutcher, EC; Quinn, PJ | 1 |
Reid, JL; Rodger, JC; Struthers, AD; Whitesmith, R | 1 |
Dietrichson, P; Espen, E | 1 |
Frishman, WH | 1 |
Albanesi Filho, FM; Brandão, AP; Oigman, W | 1 |
Kompella, UB; Lee, VH; Lee, YH | 1 |
Gemba, M; Hosaka, K; Kamiyama, M; Kobayashi, I; Konno, C; Maruo, H; Ueno, T | 1 |
Aubineau, P; Callebert, J; Launay, JM; Reynier-Rebuffel, AM; Seylaz, J | 1 |
Caldwell, GW; Evangelisto, M; Masucci, JA; White, R | 1 |
Caldwell, GW; Demarest, K; Easlick, SM; Gunnet, J; Masucci, JA | 1 |
Anderson, GM; Clark, JP; Gurwitz, JH; Lau, P; Rochon, PA; Shear, NH; Tu, JV | 1 |
Akerman, S; Järvinen, K; Karhu, M; Paronen, P; Savolainen, J; Svarfvar, B; Tarvainen, T | 1 |
Dale, J; Heldal, M; Sire, S | 1 |
Chidlow, G; Melena, J; Osborne, NN | 1 |
Clark, JI; Martin, RW; Vaezy, S; Zderic, V | 1 |
Harada, K; Kohmoto, O; Komuro, I; Maruyama, T; Matsui, H; Matsuo, H; Nagai, R; Oyama, T; Serizawa, T; Shimizu, T; Sugishita, Y; Takahashi, T; Yao, A | 1 |
Abou-Sekkina, MM; El-Ries, MA; Hassan, SS; Wassel, A | 1 |
Denet, AR; Préat, V; Ucakar, B | 1 |
Castellano, PM; Ferraro, MC; Kaufman, TS | 1 |
Asadpour-Zeynali, K; Jouyban, A; Majidi, MR | 1 |
Al-Ghananeem, AA; Al-Ghananeem, AM; Ashton, P; Crooks, PA; Cynkowska, G; Cynkowski, T; Guo, H | 1 |
Al-Ghannam, SM | 1 |
Fonarow, GC | 1 |
Hitchcock, K; Saseen, J; Sontheimer, D | 1 |
Pisklak, DM; Wawer, I; Zielińska-Pisklak, MA | 1 |
Devost, D; Goupil, E; Hébert, TE; Iorio-Morin, C; Laporte, SA; Pétrin, D; Wrzal, PK; Zingg, HH | 1 |
Mains, J; Tan, LE; Urquhart, A; Wilson, C | 1 |
Chantasart, D; Hao, J; Li, SK | 1 |
Bayart, CB; Brandling-Bennett, HA | 1 |
Fruge, JH; Massengale, WT; Rouhana, HF | 1 |
Hasanzadeh, M; Niaei, N; Shadjou, N | 1 |
Del Amo, EM; Fayyaz, A; Gardner, I; Heikkinen, EM; Jamei, M; Ranta, VP; Reinisalo, M; Ricci, GD; Toropainen, E; Urtti, A; Vellonen, KS | 1 |
Del Amo, EM; Fayyaz, A; Gardner, I; Jamei, M; Puranen, J; Ranta, VP; Ruponen, M; Toropainen, E; Urtti, A; Valtari, A; Vellonen, KS | 1 |
Chen, YW; Hsu, CW; Huang, KY; Lin, CH; Lin, PY; Matsuoka, YJ; Stubbs, B; Su, KP; Tseng, PT; Tu, YK; Wu, YC | 1 |
Ganatra, B; Gandhi, R; Kelly, A; Natkunarajah, J | 1 |
Del Amo, EM; Fayyaz, A; Gardner, I; Heikkinen, EM; Jamei, M; Puranen, J; Ranta, VP; Reinisalo, M; Ricci, GD; Ruponen, M; Toropainen, E; Urtti, A; Valtari, A; Vellonen, KS | 1 |
19 review(s) available for timolol and atenolol
Article | Year |
---|---|
Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Models, Molecular; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1988 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Comparative pharmacokinetics of beta-blockers].
Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Half-Life; Humans; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Sotalol; Timolol | 1978 |
[Beta-blockers and migraine].
Topics: Adrenergic beta-Antagonists; Atenolol; Clinical Trials as Topic; Dilatation, Pathologic; Evoked Potentials, Visual; Humans; Metoprolol; Migraine Disorders; Nadolol; Platelet Aggregation; Propranolol; Receptors, Serotonin; Timolol | 1992 |
A toxicological review of beta-adrenergic blockers.
Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Cocarcinogenesis; Ethanolamines; Female; Kinetics; Labetalol; Lethal Dose 50; Male; Metoprolol; Mice; Mutagens; Nadolol; Neoplasms, Experimental; Oxprenolol; Pindolol; Practolol; Propanolamines; Propranolol; Rats; Sotalol; Timolol | 1986 |
Advances in the medical management of renovascular hypertension.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arteriosclerosis; Atenolol; Captopril; Dipeptides; Enalapril; Female; Humans; Hypertension, Renovascular; Male; Metoprolol; Middle Aged; Nadolol; Pindolol; Propanolamines; Propranolol; Renal Artery Obstruction; Renin-Angiotensin System; Saralasin; Timolol | 1984 |
beta-Adrenoceptor antagonists: new drugs and new indications.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Glaucoma; Humans; Hypertension; Kinetics; Metoprolol; Migraine Disorders; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol | 1981 |
The use of beta blockers for the reduction of mortality after myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Atenolol; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Myocardial Infarction; Norway; Oxprenolol; Practolol; Propranolol; Random Allocation; Timolol | 1981 |
Beta blocking agents: current status in the prevention of sudden coronary death.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Atenolol; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Practolol; Propranolol; Prospective Studies; Random Allocation; Timolol | 1982 |
Beta-adrenoceptor blockade and migraine.
Topics: Adrenergic beta-Antagonists; Atenolol; Brain; Clinical Trials as Topic; Double-Blind Method; Humans; Migraine Disorders; Propranolol; Serotonin Antagonists; Timolol; Vasomotor System | 1982 |
Comparative review of beta-blocking agents.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Atenolol; Humans; Hypertension; Metoprolol; Migraine Disorders; Myocardial Infarction; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol | 1984 |
The new beta-adrenergic antagonists.
Topics: Adrenergic beta-Antagonists; Atenolol; Humans; Labetalol; Metoprolol; Nadolol; Oxprenolol; Pindolol; Propanolamines; Timolol | 1984 |
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans; Hypertension; Metoprolol; Myocardial Infarction; Oxprenolol; Pindolol; Practolol; Propranolol; Receptors, Adrenergic, beta; Risk; Sotalol; Timolol | 1984 |
Drug therapy: atenolol and timolol, two new systemic beta-adrenoceptor antagonists.
Topics: Arrhythmias, Cardiac; Atenolol; Coronary Disease; Humans; Hypertension; Kinetics; Propanolamines; Timolol | 1982 |
Beta-blockers for the post-myocardial infarction patient: current clinical evidence and practical considerations.
Topics: Adrenergic beta-Antagonists; Algorithms; Atenolol; Carbazoles; Carvedilol; Humans; Myocardial Infarction; Practice Guidelines as Topic; Propanolamines; Propranolol; Randomized Controlled Trials as Topic; Secondary Prevention; Timolol | 2006 |
Clinical inquiries. Are there big differences among beta-blockers in treating essential hypertension?
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Atenolol; Dose-Response Relationship, Drug; Drug Administration Schedule; Evidence-Based Medicine; Family Practice; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Propranolol; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Timolol; Treatment Outcome | 2007 |
Beta-blockers for childhood vascular tumors.
Topics: Administration, Oral; Administration, Topical; Adrenergic beta-Antagonists; Atenolol; Child, Preschool; Facial Neoplasms; Humans; Infant; Neoplastic Syndromes, Hereditary; Neurocutaneous Syndromes; Propranolol; Skin Neoplasms; Timolol; Treatment Outcome; Vascular Neoplasms | 2015 |
Beta blocker treatment for infantile hemangiomas.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Atenolol; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hemangioma, Capillary; Humans; Infant; Male; Nadolol; Propranolol; Skin Neoplasms; Timolol; Treatment Outcome | 2015 |
Do beta-adrenergic blocking agents increase asthma exacerbation? A network meta-analysis of randomized controlled trials.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Atenolol; Bisoprolol; Cardiovascular Diseases; Celiprolol; Disease Progression; Female; Humans; Incidence; Infusions, Intravenous; Male; Practolol; Propranolol; Randomized Controlled Trials as Topic; Risk; Sotalol; Status Asthmaticus; Timolol | 2021 |
17 trial(s) available for timolol and atenolol
Article | Year |
---|---|
Randomised study of six beta-blockers and a thiazide diuretic in essential hypertension.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Atenolol; Bendroflumethiazide; Clinical Trials as Topic; Female; Humans; Hypertension; Labetalol; Male; Middle Aged; Pindolol; Propranolol; Random Allocation; Timolol | 1978 |
Effect of beta-blockers on exercise double product (systolic blood pressure x heart rate).
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Drug Evaluation; Heart Rate; Humans; Kinetics; Male; Middle Aged; Oxprenolol; Physical Exertion; Pindolol; Propanolamines; Propranolol; Time Factors; Timolol | 1979 |
[Comparative study of atenolol and timolol in the treatment of ocular hypertension].
Topics: Atenolol; Clinical Trials as Topic; Drug Evaluation; Glaucoma; Humans; Intraocular Pressure; Propanolamines; Timolol | 1978 |
[Beta-blockers and migraine].
Topics: Adrenergic beta-Antagonists; Atenolol; Clinical Trials as Topic; Dilatation, Pathologic; Evoked Potentials, Visual; Humans; Metoprolol; Migraine Disorders; Nadolol; Platelet Aggregation; Propranolol; Receptors, Serotonin; Timolol | 1992 |
The importance of potassium and lactate for maximal exercise performance during beta blockade.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Glucose; Blood Pressure; Double-Blind Method; Exercise; Heart Rate; Humans; Hydrogen-Ion Concentration; Lactates; Male; Potassium; Random Allocation; Timolol | 1989 |
Epinephrine-induced hypokalemia: the role of beta adrenoceptors.
Topics: Adult; Atenolol; Blood Pressure; Electrocardiography; Epinephrine; Heart Rate; Humans; Hypokalemia; Potassium; Receptors, Adrenergic, beta; Timolol | 1986 |
Duration of action of beta blockers.
Topics: Adrenergic beta-Antagonists; Adult; Alprenolol; Atenolol; Blood Pressure; Coronary Disease; Heart Rate; Humans; Metoprolol; Penbutolol; Physical Exertion; Pindolol; Propranolol; Regression Analysis; Rest; Sotalol; Time Factors; Timolol | 1980 |
Regulation of intraocular pressure and pupil size by beta-blockers and epinephrine.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Double-Blind Method; Drug Interactions; Epinephrine; Female; Hemodynamics; Humans; Intraocular Pressure; Male; Propranolol; Pupil; Timolol | 1980 |
The use of beta blockers for the reduction of mortality after myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Atenolol; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Myocardial Infarction; Norway; Oxprenolol; Practolol; Propranolol; Random Allocation; Timolol | 1981 |
Adrenergic beta-receptor blockers, adrenalin and intraocular pressure.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adrenergic beta-Antagonists; Adult; Atenolol; Clinical Trials as Topic; Drug Combinations; Epinephrine; Female; Humans; Intraocular Pressure; Male; Middle Aged; Propranolol; Pupil; Random Allocation; Timolol | 1982 |
Beta blocking agents: current status in the prevention of sudden coronary death.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Alprenolol; Atenolol; Clinical Trials as Topic; Coronary Disease; Death, Sudden; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Practolol; Propranolol; Prospective Studies; Random Allocation; Timolol | 1982 |
Beta-adrenoceptor blockade and migraine.
Topics: Adrenergic beta-Antagonists; Atenolol; Brain; Clinical Trials as Topic; Double-Blind Method; Humans; Migraine Disorders; Propranolol; Serotonin Antagonists; Timolol; Vasomotor System | 1982 |
The use of beta-adrenergic blocking drugs in patients with myocardial infarction.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Atenolol; Clinical Trials as Topic; Humans; Hypertension; Metoprolol; Myocardial Infarction; Oxprenolol; Pindolol; Practolol; Propranolol; Receptors, Adrenergic, beta; Risk; Sotalol; Timolol | 1984 |
Atenolol and timolol.
Topics: Adult; Aged; Atenolol; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Propanolamines; Timolol | 1982 |
The effects of cardioselective and non-selective beta-adrenoceptor blockade on the hypokalaemic and cardiovascular responses to adrenomedullary hormones in man.
Topics: Adult; Atenolol; Blood Pressure; Epinephrine; Heart Rate; Humans; Hypokalemia; Male; Myocardial Infarction; Potassium; Propanolamines; Timolol | 1983 |
Effects of timolol and atenolol on benign essential tremor: placebo-controlled studies based on quantitative tremor recording.
Topics: Adult; Aged; Atenolol; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Placebos; Propanolamines; Timolol; Tremor | 1981 |
Randomised training after myocardial infarction: short and long-term effects of exercise training after myocardial infarction in patients on beta-blocker treatment. A randomized, controlled study.
Topics: Adrenergic beta-Antagonists; Aged; Atenolol; Electrocardiography; Exercise Test; Exercise Therapy; Female; Follow-Up Studies; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Time Factors; Timolol; Treatment Outcome | 2000 |
91 other study(ies) available for timolol and atenolol
Article | Year |
---|---|
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. 2.
Topics: Adrenergic beta-Antagonists; Animals; Female; Guinea Pigs; Heart Rate; Hydrogen Bonding; Imidazoles; In Vitro Techniques; Receptors, Adrenergic, beta; Solubility; Structure-Activity Relationship | 1986 |
(Acyloxy)alkyl carbamates as novel bioreversible prodrugs for amines: increased permeation through biological membranes.
Topics: Adrenergic beta-Antagonists; Amines; Carbamates; Cell Membrane Permeability; Pharmaceutical Preparations; Prodrugs | 1988 |
Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.
Topics: Adrenergic alpha-Agonists; Animals; Female; Guinea Pigs; Heart; Imidazoles; Indicators and Reagents; Isoproterenol; Magnetic Resonance Spectroscopy; Receptors, Adrenergic; Receptors, Adrenergic, beta; Structure-Activity Relationship | 1983 |
Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.
Topics: Indoles; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Piperazines; Propanolamines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Algorithms; Animals; Cell Line; CHO Cells; Cricetinae; Dioxoles; Humans; Propanolamines; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3 | 2005 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
Topics: Adrenergic beta-Antagonists; Animals; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Glaucoma; Humans; Intraocular Pressure; Male; Molecular Targeted Therapy; Rabbits; Receptors, Adrenergic, beta; Structure-Activity Relationship | 2018 |
Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Repositioning; Drug Screening Assays, Antitumor; Humans; Melanoma; Molecular Docking Simulation; Molecular Structure; Propanols; Skin Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Once-daily treatment of hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Hypertension; Metoprolol; Pindolol; Propranolol; Timolol | 1976 |
Direct myocardial depressant effects of several beta-adrenergic blocking agents in the unanesthetized atherosclerotic rabbit.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Arteriosclerosis; Atenolol; Blood Pressure; Depression, Chemical; Heart Rate; Isoproterenol; Male; Oxprenolol; Pindolol; Propanolamines; Propranolol; Rabbits; Timolol | 1978 |
Renin-suppressive potency of various beta-adrenergic blocking agents at supine rest and during upright exercise.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Humans; Male; Oxprenolol; Physical Exertion; Pindolol; Posture; Practolol; Propranolol; Renin; Timolol | 1975 |
Comparison of the effects of nine beta-adrenergic blocking agents on intraocular pressure in rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Drug Tolerance; Ethanolamines; Intraocular Pressure; Metoprolol; Oxprenolol; Pindolol; Practolol; Propranolol; Rabbits; Sotalol; Timolol | 1979 |
The treatment of glaucoma: role of beta-blocking agents.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Atenolol; Glaucoma; Humans; Intraocular Pressure; Propranolol; Timolol | 1979 |
Conjunctival penetration of insulin and peptide drugs in the albino rabbit.
Topics: Administration, Topical; Animals; Atenolol; Bile Acids and Salts; Conjunctiva; Enkephalin, Methionine; Glycocholic Acid; Insulin; Male; Molecular Weight; Ophthalmic Solutions; Rabbits; Substance P; Timolol | 1992 |
A mechanistic study on enhancement of rectal permeability to insulin in the albino rabbit.
Topics: Animals; Atenolol; Bile Acids and Salts; Cell Membrane Permeability; Edetic Acid; Insulin; Male; Rabbits; Rectum; Timolol | 1992 |
[Effects of antihypertensive therapy with selective and non-selective beta blocking agents on dimensions and function of the left ventricle].
Topics: Acebutolol; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Blood Pressure; Echocardiography; Female; Heart Ventricles; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nadolol; Pindolol; Timolol; Ventricular Function | 1991 |
Beta 1- and beta 2-adrenoceptor subtypes in canine intrathoracic efferent sympathetic nervous system regulating the heart.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Atropine; Axons; Dogs; Efferent Pathways; Electric Stimulation; Female; Ganglia, Sympathetic; Heart Conduction System; Isoproterenol; Male; Myocardial Contraction; Propanolamines; Receptors, Adrenergic, beta; Stellate Ganglion; Sympathetic Nervous System; Timolol | 1991 |
Formulation influence on conjunctival penetration of four beta blockers in the pigmented rabbit: a comparison with corneal penetration.
Topics: Animals; Atenolol; Benzalkonium Compounds; Betaxolol; Chromatography, High Pressure Liquid; Conjunctiva; Cornea; Edetic Acid; Hydrogen-Ion Concentration; Levobunolol; Male; Ophthalmic Solutions; Rabbits; Timolol | 1991 |
Corneal penetration of 5-fluorouracil and its improvement by prodrug derivatization in the albino rabbit: implication in glaucoma filtration surgery.
Topics: Animals; Atenolol; Cornea; Female; Fluorouracil; Glaucoma; Histological Techniques; Hydrolysis; Osmolar Concentration; Prodrugs; Rabbits; Timolol | 1991 |
Epinephrine facilitates neurogenic responses in isolated segments of dog mesenteric arteries.
Topics: Animals; Atenolol; Dogs; Electric Stimulation; Epinephrine; Female; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Timolol | 1989 |
86Rb(K) influx and [3H]ouabain binding by human platelets: evidence for beta-adrenergic stimulation of Na-K ATPase activity.
Topics: Adult; Albuterol; Atenolol; Biological Transport, Active; Blood Platelets; Cell Membrane; Epinephrine; Humans; Isoproterenol; Norepinephrine; Ouabain; Phentolamine; Potassium; Receptors, Adrenergic, beta; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Timolol; Tritium | 1989 |
Serum potassium concentrations following succinylcholine in patients undergoing beta-adrenoceptor blocking therapy.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Blood Pressure; Heart Rate; Humans; Metoprolol; Middle Aged; Nadolol; Ophthalmic Solutions; Potassium; Propranolol; Succinylcholine; Time Factors; Timolol | 1989 |
Adrenaline and ion flux in isolated human leucocytes.
Topics: Atenolol; Biological Transport, Active; Epinephrine; Humans; Ion Channels; Leukocytes; Norepinephrine; Potassium; Sodium; Timolol | 1985 |
Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Chromatography, High Pressure Liquid; Debrisoquin; Heart Rate; Humans; Kinetics; Male; Oxidation-Reduction; Phenotype; Physical Exertion; Spectrophotometry, Ultraviolet; Timolol | 1985 |
Exercise training during chronic beta blockade in cardiovascular disease.
Topics: Adrenergic beta-Antagonists; Atenolol; Coronary Artery Bypass; Female; Heart Rate; Humans; Male; Metoprolol; Myocardial Infarction; Nadolol; Physical Exertion; Propanolamines; Propranolol; Timolol | 1985 |
Debrisoquine polymorphism and the metabolism and action of metoprolol, timolol, propranolol and atenolol.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Debrisoquin; Genetic Variation; Humans; Hypertension; Isoquinolines; Kinetics; Male; Metoprolol; Oxidation-Reduction; Phenotype; Polymorphism, Genetic; Propranolol; Structure-Activity Relationship; Timolol | 1986 |
Influence of some beta blockers (pindolol, atenolol, timolol and metoprolol) on aggregation and arachidonic acid metabolism in human platelets.
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Arachidonic Acid; Arachidonic Acids; Atenolol; Blood Platelets; Collagen; Epinephrine; Humans; Metoprolol; Phospholipids; Pindolol; Platelet Aggregation; Thromboxane B2; Timolol | 1987 |
Placental transfer of beta-adrenergic antagonists studied in an in vitro perfusion system of human placental tissue.
Topics: Adrenergic beta-Antagonists; Atenolol; Celiprolol; Female; Humans; In Vitro Techniques; Labetalol; Maternal-Fetal Exchange; Placenta; Pregnancy; Propanolamines; Propranolol; Timolol | 1988 |
Effects of atenolol and some other beta-adrenoceptor blocking agents on norepinephrine-induced responses in isolated and perfused rat hearts.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Heart; Heart Rate; In Vitro Techniques; Male; Metoprolol; Myocardial Contraction; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Timolol | 1988 |
Effects of antiglaucoma drugs on [32P]orthophosphate incorporation into phospholipids of cat iris and ciliary process.
Topics: Animals; Atenolol; Carbachol; Cats; Ciliary Body; Intraocular Pressure; Iris; Phosphates; Phospholipids; Pilocarpine; Propranolol; Timolol | 1985 |
Ocular penetration of beta-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Aqueous Humor; Atenolol; Carbon Radioisotopes; Ciliary Body; Cornea; Eye; Female; Iris; Male; Metoprolol; Nictitating Membrane; Propranolol; Rabbits; Timolol; Tritium | 1980 |
Effects of selective beta 1- and beta 2-adrenoreceptor agonists and antagonists on intraocular pressure in the cat.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Atenolol; Carbachol; Cats; Dose-Response Relationship, Drug; Echothiophate Iodide; Eye; Female; Intraocular Pressure; Male; Sympathectomy; Timolol | 1981 |
Comparison of four different beta-adrenoceptor blocking drugs on lymphocyte isoprenaline-stimulated cyclic AMP production.
Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Atenolol; Cyclic AMP; Drug Interactions; Female; Humans; Isoproterenol; Lymphocytes; Male; Middle Aged; Pindolol; Timolol | 1981 |
Abrupt and gradual change from clonidine to beta blockers in hypertension.
Topics: Adrenergic beta-Antagonists; Atenolol; Clonidine; Drug Interactions; Female; Humans; Hypertension; Male; Middle Aged; Norepinephrine; Pilot Projects; Propanolamines; Substance Withdrawal Syndrome; Timolol | 1982 |
Managing angina with beta blockers.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Humans; Metoprolol; Nadolol; Nitrates; Propanolamines; Propranolol; Timolol | 1982 |
The chronic effects of beta-adrenoreceptor blocking agents on transmitter overflow in the anococcygeus muscle of the rat.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Electric Stimulation; Male; Muscle, Smooth; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Timolol | 1983 |
Central haemodynamic effects of beta blockers in hypertension. A comparison between atenolol, metoprolol, timolol, penbutolol, alprenolol pindolol and bunitrolol.
Topics: Adrenergic beta-Antagonists; Alprenolol; Atenolol; Hemodynamics; Humans; Hypertension; Metoprolol; Pindolol; Propanolamines; Time Factors; Timolol | 1983 |
[Effect of beta-adrenoblockers on prostaglandin-induced ocular hypertension in rabbits].
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Dinoprostone; Male; Ocular Hypertension; Oxprenolol; Propanolamines; Propranolol; Prostaglandins E; Rabbits; Timolol | 1983 |
Beta-blockers in isoproterenol-enhanced essential tremor.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Humans; Isoproterenol; Metoprolol; Middle Aged; Propranolol; Timolol; Tremor | 1984 |
Beta-adrenergic antagonist inhibition of hepatic 3,5,3'-triiodothyronine production.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Atenolol; Dithiothreitol; Liver; Male; Metoprolol; Nadolol; Pindolol; Propanolamines; Propranolol; Rats; Rats, Inbred Strains; Timolol; Triiodothyronine | 1984 |
Beta-adrenergic blockers. Choosing among them.
Topics: Adrenergic beta-Antagonists; Atenolol; Cardiovascular Diseases; Humans; Kinetics; Metoprolol; Nadolol; Pindolol; Propanolamines; Propranolol; Timolol | 1984 |
Class III action of beta-blocking agents.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Atenolol; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Female; Heart; Heart Ventricles; Male; Nadolol; Oxprenolol; Pindolol; Propanolamines; Propranolol; Sotalol; Timolol | 1984 |
Evidence that beta 1-adrenoceptor activation mediates isoproterenol-stimulated renin secretion in the rat.
Topics: Animals; Atenolol; In Vitro Techniques; Isoproterenol; Kidney Cortex; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Renin; Timolol | 1983 |
The action of beta-adrenoceptor antagonists on rat heart mitochondrial function in vitro: a comparison of propranolol, timolol, and atenolol.
Topics: Animals; Atenolol; Depression, Chemical; Electron Transport; Male; Mitochondria, Heart; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Oxygen Consumption; Propranolol; Rats; Rats, Inbred Strains; Submitochondrial Particles; Timolol | 1984 |
[Treatment of arterial hypertension: comparative study of atenolol + chlorthalidone vs. timolol maleate-hydrochlorthiazide-amiloride association].
Topics: Adult; Aged; Amiloride; Atenolol; Blood Pressure; Chlorthalidone; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propanolamines; Pyrazines; Timolol | 1981 |
Systemic absorption pathways of topically applied beta adrenergic antagonists in the pigmented rabbit.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Atenolol; Betaxolol; Biological Availability; Conjunctiva; Eye; Levobunolol; Male; Nasal Mucosa; Nasolacrimal Duct; Rabbits; Time Factors; Timolol | 1993 |
Relationship between amount of beta-blockers permeating through the stratum corneum and skin irritation after application of beta-blocker adhesive patches to guinea pig skin.
Topics: Acebutolol; Administration, Cutaneous; Adrenergic beta-Antagonists; Alprenolol; Animals; Atenolol; Dermatitis, Irritant; Guinea Pigs; Male; Oxprenolol; Skin; Skin Absorption; Timolol | 1997 |
NE inhibits cerebrovascular mast cell exocytosis induced by cholinergic and peptidergic agonists.
Topics: Adrenergic Antagonists; Animals; Atenolol; Carbachol; Cerebral Arteries; Cerebrovascular Circulation; Exocytosis; In Vitro Techniques; Kinetics; Male; Mast Cells; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rabbits; Serotonin; Timolol | 1997 |
Evaluation of the immobilized artificial membrane phosphatidylcholine. Drug discovery column for high-performance liquid chromatographic screening of drug-membrane interactions.
Topics: Acebutolol; Acetonitriles; Adrenergic beta-Antagonists; Alprenolol; Aniline Compounds; Atenolol; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Membranes, Artificial; Metoprolol; Models, Chemical; Osmolar Concentration; Oxprenolol; Phosphatidylcholines; Pindolol; Propranolol; Reproducibility of Results; Timolol | 1998 |
In vitro permeability of eight beta-blockers through Caco-2 monolayers utilizing liquid chromatography/electrospray ionization mass spectrometry.
Topics: Acebutolol; Adrenergic beta-Antagonists; Alprenolol; Atenolol; Biological Availability; Caco-2 Cells; Cell Membrane Permeability; Chromatography, Liquid; Epithelial Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Mass Spectrometry; Metoprolol; Molecular Structure; Oxprenolol; Pindolol; Propranolol; Research Design; Timolol | 1998 |
Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose.
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Atenolol; Chlorthalidone; Confidence Intervals; Databases as Topic; Diuretics; Drug Compounding; Evaluation Studies as Topic; Female; Humans; Hydrochlorothiazide; Logistic Models; Male; Metolazone; Metoprolol; Myocardial Infarction; Odds Ratio; Ontario; Propranolol; Retrospective Studies; Sex Factors; Sodium Chloride Symporter Inhibitors; Timolol | 1999 |
Drug release from a porous ion-exchange membrane in vitro.
Topics: Acrylic Resins; Adsorption; Atenolol; Biocompatible Materials; Cations; Dexmedetomidine; Diazepam; Drug Delivery Systems; Hydrogen-Ion Concentration; Ion Transport; Kinetics; Membranes, Artificial; Polyvinyls; Propranolol; Sotalol; Surface Properties; Timolol | 1999 |
Betaxolol, a beta(1)-adrenoceptor antagonist, reduces Na(+) influx into cortical synaptosomes by direct interaction with Na(+) channels: comparison with other beta-adrenoceptor antagonists.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Atenolol; Batrachotoxins; Betaxolol; Binding, Competitive; Carteolol; Cerebral Cortex; Dose-Response Relationship, Drug; Kinetics; Levobunolol; Membranes; Propranolol; Rats; Rats, Wistar; Saxitoxin; Sodium; Sodium Channels; Sodium Radioisotopes; Synaptosomes; Timolol; Tritium | 2000 |
Ocular drug delivery using 20-kHz ultrasound.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Betaxolol; Carteolol; Cornea; Drug Delivery Systems; Epithelium; Models, Animal; Permeability; Rabbits; Timolol; Ultrasonics | 2002 |
Characteristic effects of alpha1-beta1,2-adrenergic blocking agent, carvedilol, on [Ca2+]i in ventricular myocytes compared with those of timolol and atenolol.
Topics: Adrenergic Antagonists; Adrenergic beta-Antagonists; Animals; Atenolol; Calcium; Calcium Channels, L-Type; Carbazoles; Carvedilol; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Intracellular Membranes; Male; Myocytes, Cardiac; Osmolar Concentration; Propanolamines; Receptors, Adrenergic, beta; Timolol | 2003 |
Polymeric matrix membrane sensors for sensitive potentiometric determination of some beta-blockers in pharmaceutical preparations.
Topics: Adrenergic beta-Antagonists; Atenolol; Bisoprolol; Indicators and Reagents; Ions; Metoprolol; Phosphates; Polyvinyl Chloride; Potentiometry; Propranolol; Sensitivity and Specificity; Timolol; Tungsten Compounds | 2003 |
Transdermal delivery of timolol and atenolol using electroporation and iontophoresis in combination: a mechanistic approach.
Topics: Administration, Cutaneous; Adrenergic beta-Antagonists; Atenolol; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Electrochemistry; Electroporation; Humans; In Vitro Techniques; Iontophoresis; Lipids; Mannitol; Osmosis; Spectrophotometry, Ultraviolet; Timolol | 2003 |
Chemometric determination of amiloride hydrochloride, atenolol, hydrochlorothiazide and timolol maleate in synthetic mixtures and pharmaceutical formulations.
Topics: Amiloride; Atenolol; Chemistry, Pharmaceutical; Hydrochlorothiazide; Least-Squares Analysis; Spectrophotometry, Ultraviolet; Timolol | 2004 |
Modeling the electrophoretic mobility of beta-blockers in capillary electrophoresis using artificial neural networks.
Topics: Adrenergic beta-Antagonists; Atenolol; Electrolytes; Electrophoresis, Capillary; Electrophoretic Mobility Shift Assay; Labetalol; Models, Chemical; Neural Networks, Computer; Pharmaceutical Preparations; Practolol; Predictive Value of Tests; Propranolol; Solvents; Technology, Pharmaceutical; Timolol | 2005 |
Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.
Topics: Adrenergic beta-Antagonists; Atenolol; Ethacrynic Acid; Glaucoma; Polyethylene Glycols; Prodrugs; Timolol | 2005 |
A simple spectrophotometric method for the determination of beta-blockers in dosage forms.
Topics: Adrenergic beta-Antagonists; Atenolol; Bromcresol Purple; Bromphenol Blue; Bromthymol Blue; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Chloroform; Coloring Agents; Dose-Response Relationship, Drug; Ions; Kinetics; Models, Chemical; Nadolol; Spectrophotometry, Ultraviolet; Tablets; Thermodynamics; Timolol | 2006 |
1H and 13C NMR characteristics of β-blockers.
Topics: Acebutolol; Acids; Adrenergic beta-Antagonists; Alkalies; Alprenolol; Atenolol; Carbazoles; Carbon Isotopes; Carvedilol; Nuclear Magnetic Resonance, Biomolecular; Pindolol; Propanolamines; Propranolol; Protons; Timolol | 2011 |
Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Allosteric Regulation; Atenolol; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Female; Humans; Immunoprecipitation; Isoproterenol; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myometrium; Oxytocin; Phosphorylation; Propranolol; Protein Binding; Protein Multimerization; Receptors, Adrenergic, beta-2; Receptors, Oxytocin; Recombinant Fusion Proteins; Signal Transduction; Timolol; Vasotocin | 2012 |
A pharmacokinetic study of a combination of beta adrenoreceptor antagonists - in the isolated perfused ovine eye.
Topics: Adrenergic beta-Antagonists; Animals; Anterior Eye Segment; Atenolol; Choroid; Intravitreal Injections; Posterior Eye Segment; Propranolol; Retina; Sheep; Timolol; Tissue Distribution | 2012 |
Evaluation of skin permeation of β-blockers for topical drug delivery.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Adult; Atenolol; Betaxolol; Epidermis; Humans; Middle Aged; Propranolol; Skin; Skin Absorption; Timolol; Young Adult | 2013 |
Molecular interaction of some cardiovascular drugs with human serum albumin at physiological-like conditions: A new approach.
Topics: Amiodarone; Atenolol; Captopril; Cardiovascular Agents; Humans; Hydrophobic and Hydrophilic Interactions; Propranolol; Protein Binding; Serum Albumin, Human; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Static Electricity; Timolol | 2018 |
Ocular Intracameral Pharmacokinetics for a Cocktail of Timolol, Betaxolol, and Atenolol in Rabbits.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Aqueous Humor; Atenolol; Betaxolol; Chromatography, Liquid; Drug Combinations; Half-Life; Injections, Intraocular; Intraocular Pressure; Male; Metabolic Clearance Rate; Rabbits; Tandem Mass Spectrometry; Timolol; Tissue Distribution | 2020 |
Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Animals; Atenolol; Betaxolol; Biological Availability; Chromatography, Liquid; Ophthalmic Solutions; Rabbits; Tandem Mass Spectrometry; Timolol | 2020 |
Treatment of eruptive angiokeratomas of the flanks with topical and oral beta-blockers.
Topics: Abdomen; Administration, Oral; Administration, Topical; Adrenergic beta-Antagonists; Angiokeratoma; Atenolol; Female; Humans; Skin Neoplasms; Timolol; Young Adult | 2021 |
Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail: Tissue exposures in the rabbit eye.
Topics: Administration, Ophthalmic; Animals; Aqueous Humor; Atenolol; Betaxolol; Biological Availability; Drug Combinations; Ophthalmic Solutions; Outcome Assessment, Health Care; Rabbits; Solubility; Tears; Timolol; Tissue Distribution | 2021 |