tilimycin has been researched along with tilivalline* in 1 studies
1 other study(ies) available for tilimycin and tilivalline
Article | Year |
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Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS
Non-ribosomal peptides are one class of bacterial metabolites formed by gut microbiota. Intestinal resident Klebsiella oxytoca produces two pyrrolobenzodiazepines, tilivalline and tilimycin, via the same nonribosomal biosynthesis platform. These molecules cause human disease by genotoxic and tubulin inhibitory activities resulting in apoptosis of the intestinal epithelium, loss of barrier integrity and ultimately colitis. Here we report a fast, reliable, HPLC-HR-ESMS Topics: Animals; Bacterial Toxins; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Enterotoxins; Humans; Pyrroles | 2021 |