tilimycin and tilivalline

tilimycin has been researched along with tilivalline* in 1 studies

Other Studies

1 other study(ies) available for tilimycin and tilivalline

Article	Year
Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS Talanta, 2021, Jan-15, Volume: 222 Non-ribosomal peptides are one class of bacterial metabolites formed by gut microbiota. Intestinal resident Klebsiella oxytoca produces two pyrrolobenzodiazepines, tilivalline and tilimycin, via the same nonribosomal biosynthesis platform. These molecules cause human disease by genotoxic and tubulin inhibitory activities resulting in apoptosis of the intestinal epithelium, loss of barrier integrity and ultimately colitis. Here we report a fast, reliable, HPLC-HR-ESMS Topics: Animals; Bacterial Toxins; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Enterotoxins; Humans; Pyrroles	2021

Article

Year

Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS

Talanta, 2021, Jan-15, Volume: 222

Non-ribosomal peptides are one class of bacterial metabolites formed by gut microbiota. Intestinal resident Klebsiella oxytoca produces two pyrrolobenzodiazepines, tilivalline and tilimycin, via the same nonribosomal biosynthesis platform. These molecules cause human disease by genotoxic and tubulin inhibitory activities resulting in apoptosis of the intestinal epithelium, loss of barrier integrity and ultimately colitis. Here we report a fast, reliable, HPLC-HR-ESMS

Topics: Animals; Bacterial Toxins; Benzodiazepines; Benzodiazepinones; Chromatography, High Pressure Liquid; Enterotoxins; Humans; Pyrroles

2021