Page last updated: 2024-08-22

tiletamine hydrochloride and dehydroxymethylepoxyquinomicin

tiletamine hydrochloride has been researched along with dehydroxymethylepoxyquinomicin in 148 studies

Research

Studies (148)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's61 (41.22)29.6817
2010's79 (53.38)24.3611
2020's8 (5.41)2.80

Authors

AuthorsStudies
Ariga, A; Inoue, J; Matsumoto, N; Namekawa, J; Umezawa, K1
Chaicharoenpong, C; Kato, K; Umezawa, K2
Chaicharoenpong, C; Umezawa, K1
Horiguchi, Y; Kikuchi, E; Kuroda, K; Murai, M; Nakashima, J; Ohigashi, T; Oya, M; Shima, Y; Takahashi, N; Umezawa, K1
Asano, T; Hayakawa, M; Kosaka, T; Miyajima, A; Seta, K; Umezawa, K1
Horiguchi, Y; Kuroda, K; Murai, M; Nakashima, J; Umezawa, K1
Maeda, S; Namba, H; Ohtsuru, A; Saenko, VA; Starenki, DV; Umezawa, K; Yamashita, S1
Dewan, MZ; Higashihara, M; Honda, M; Horie, R; Itoh, K; Mizoguchi, H; Okamura, T; Sasaki, M; Sata, T; Umezawa, K; Watanabe, M; Watanabe, T; Yamamoto, N1
Bando, H; Matsumoto, G; Muta, M; Nakamura, T; Namekawa, J; Tohyama, K; Toi, M; Umezawa, K1
Aoki, K; Asagiri, M; Kubota, T; Ohya, K; Oka, K; Osada, T; Saito, H; Sugiyama, C; Takatsuna, H; Takayanagi, H; Umezawa, K1
Horie, R; Ishida, A; Ishida, T; Kumasaka, T; Ohsugi, T; Umezawa, K; Urano, T; Watanabe, T; Yamaguchi, K1
Morita, S; Nagatsu, T; Sawada, M; Takatsuna, H; Umezawa, K1
Aizawa, S; Higashihara, M; Horie, R; Ishida, T; Kamihira, S; Kikuchi, H; Koga, S; Maruyama-Nagai, M; Ohsugi, T; Okayama, A; Shoda, M; Umezawa, K; Uozumi, K; Utsunomiya, A; Watanabe, M; Watanabe, T; Yamada, Y; Yamaguchi, K1
Horie, R; Ishida, A; Ishida, T; Kumasaka, T; Ohsugi, T; Umezawa, K; Watanabe, T; Yamaguchi, K1
Hata, H; Matsuno, F; Mitsuya, H; Nakamura, M; Okuno, Y; Sonoki, T; Taniguchi, I; Tatetsu, H; Umezawa, K; Uneda, S1
Horiguchi, Y; Kanao, K; Kikuchi, E; Kuroda, K; Miyajima, A; Murai, M; Nakashima, J; Ohigashi, T; Umezawa, K1
Matsumoto, G; Misumi, K; Muta, M; Okamoto, A; Suzuki, T; Toi, M; Tsuruta, K; Umezawa, K1
Kubota, T; Miyasaka, N; Nanki, T; Umezawa, K; Wakamatsu, K1
Ito, A; Komune, S; Kuratomi, Y; Masuda, M; Nakashima, T; Ruan, HY; Umezawa, K; Weinstein, IB; Yamamoto, T; Yasumatsu, R1
Higashihara, M; Horie, R; Motoji, T; Okamura, T; Shoda, M; Taira, M; Umezawa, K; Utsunomiya, A; Watanabe, M; Watanabe, T1
Hayakawa, M; Horiguchi, Y; Ito, K; Mizuno, R; Murai, M; Oya, M; Sato, A; Umezawa, K1
Alaimo, A; Carina, V; Cervello, M; Cusimano, A; D'Alessandro, N; Labbozzetta, M; Maurici, A; Notarbartolo, M; Poma, P; Sanguedolce, R1
Horie, R; Umezawa, K; Watanabe, T1
Eguchi, K; Fukuta, M; Goto, T; Hamasaki, K; Ichikawa, T; Ishikawa, H; Kawashimo, H; Matsumoto, K; Motoyoshi, Y; Nakao, K; Nishimura, D; Shibata, H; Taura, N; Umezawa, K1
Umezawa, K3
Suzuki, E; Umezawa, K1
Chiba, T; Ishigami, A; Kaneko, E; Kondo, Y; Maruyama, N; Shimokado, K; Shinozaki, S; Umezawa, K1
Aoyagi, T; Furukawa, H; Haga, S; Itoh, T; Ozaki, M; Shimamura, T; Suzuki, T; Taniguchi, M; Todo, S; Ueki, S; Umezawa, K; Yamashita, K1
Utsunomya, A1
Cervello, M; D'Alessandro, N; Giannitrapani, L; Labbozzetta, M; Montalto, G; Notarbartolo, M; Poma, P1
Dewan, MZ; Higashihara, M; Honda, M; Horie, R; Kadin, ME; Sata, T; Shoda, M; Taira, M; Umezawa, K; Watanabe, M; Watanabe, T; Yamamoto, N1
Ikeda, Y; Kimura, N; Kizaki, M; Kohmura, K; Miyakawa, Y; Umezawa, K1
Inoue, M; Ishida, S; Izumi-Nagai, K; Koto, T; Nagai, N; Oike, Y; Ozawa, Y; Satofuka, S; Tsubota, K; Umezawa, K; Yamashiro, K1
Horie, R; Ishida, T; Kumasaka, T; Ohsugi, T; Okada, S; Umezawa, K; Watanabe, T; Yamaguchi, K1
Ikeda, Y; Kawai, Y; Ohno, O; Sakurai, K; Shima, Y; Umezawa, K; Watanabe, K1
Namba, H; Saenko, V; Yamashita, S1
Aoki, K; Hoshino, M; Komano, Y; Kubota, T; Miyasaka, N; Nanki, T; Ohya, K; Umezawa, K1
Ikezoe, T; Jing, Y; Nishioka, C; Umezawa, K; Yokoyama, A1
Hirose, H; Horimai, C; Itoh, H; Miyashita, K; Saisho, Y; Takei, I; Umezawa, K1
Hirano, A; Makino, S; Mitsutake, N; Nakashima, M; Ohtsuru, A; Saenko, VA; Tanaka, K; Umezawa, K; Yamashita, S1
Dewan, MZ; Honda, M; Horie, R; Ishida, T; Miyake, A; Sata, T; Umezawa, K; Watanabe, M; Watanabe, T; Yamamoto, N1
Aoyagi, T; Fukai, M; Furukawa, H; Jomen, W; Ozaki, M; Suzuki, T; Todo, S; Ueki, S; Umezawa, K; Yamashita, K1
Ajima, H; Fukai, M; Furukawa, H; Kishino, S; Mochizuki, N; Ohno, K; Ozaki, M; Shiino, M; Todo, S; Umezawa, K; Watanabe, E1
Sugiyama, C; Suzuki, E; Umezawa, K1
Matsuse, M; Meng, Z; Mitsutake, N; Nakashima, M; Namba, H; Ohtsuru, A; Saenko, V; Starenki, D; Takakura, S; Umezawa, K; Yamashita, S1
Asano, T; Horiguchi, Y; Kikuchi, E; Kosaka, T; Miyajima, A; Nakashima, J; Ohigashi, T; Oya, M; Umezawa, K1
Horie, R; Kozawa, I; Takeiri, M; Umezawa, K; Yamamoto, M1
Horiuchi, K; Kawai, A; Morioka, H; Nakayama, R; Nishimoto, K; Ozaki, T; Sonobe, H; Susa, M; Suzuki, Y; Takaishi, H; Toyama, Y; Umezawa, K; Yabe, H1
Higashihara, M; Horie, R; Nakashima, M; Togano, T; Umezawa, K; Watanabe, M; Watanabe, T2
Bonavida, B; Huerta-Yepez, S; Jazirehi, AR; Martinez-Maza, O; Martinez-Paniagua, M; Umezawa, K; Vega, MI1
Ninomiya, Y; Suzuki, E; Umezawa, K1
Bonavida, B; Katsman, A; Umezawa, K1
Azzolina, A; Cervello, M; D'Alessandro, N; Lampiasi, N; McCubrey, JA; Montalto, G; Umezawa, K1
Dabaghmanesh, N; Horie, R; Ishida, T; Katano, H; Matsubara, A; Miyake, A; Nakano, K; Umezawa, K; Watanabe, T1
Chan, AT; Cheng, SH; Ho, Y; Lui, VW; Ng, MH; Tsang, CM; Tsao, SW; Umezawa, K; Wong, EY; Wong, JH1
Ishikawa, Y; Nishiyama, S; Obata, R; Saitoh, T; Suzuki, E; Takasugi, A; Umezawa, K1
Kato, K; Kozawa, I; Suenaga, K; Teruya, T; Umezawa, K1
Kawakami, Y; Okada, S; Onami, Y; Sasaki, Y; Tsukamoto, N; Umezawa, K1
Fukuya, Y; Hashimoto, R; Kanda, T; Kubota, T; Miyasaka, N; Nanki, T; Okamura, Y; Suzuki, H; Umezawa, K1
Higashihara, M; Horie, R; Nakashima, M; Sasaki, M; Togano, T; Tsuruo, T; Umezawa, K; Watanabe, M; Watanabe, T1
Barak, V; Chowers, I; Dror, R; Lederman, M; Pe'er, J; Umezawa, K1
Ishida, S; Iwabuchi, K; Iwata, D; Kitaichi, N; Miyazaki, A; Namba, K; Ohno, S; Onoé, K; Ozaki, M; Todo, S; Umezawa, K; Yamashita, K; Yoshida, K1
Aburatani, H; Gotoh, N; Hinohara, K; Isagawa, T; Kobayashi, S; Kuroda, M; Murohashi, M; Tojo, A; Tsuji, S; Umezawa, K1
Horiguchi, Y; Kanai, K; Kikuchi, E; Kodaira, K; Kosugi, M; Matsumoto, K; Miyajima, A; Nakagawa, K; Oya, M; Suzuki, E; Tachibana, M; Umezawa, K1
Hara, T; Horie, R; Ishida, T; Miyake, A; Umezawa, K; Watanabe, T; Yamagishi, M1
Caggia, S; Cardile, V; Frasca, G; Libra, M; Malaponte, G; Panico, A; Umezawa, K1
Bevelacqua, Y; Caggia, S; Cardile, V; Coco, M; Frasca, G; Libra, M; Malaponte, G; Mazzarino, MC; Stivala, F; Umezawa, K1
Kikuchi, E; Kono, H; Kosaka, T; Maeda, T; Miyajima, A; Mizuno, R; Nakagawa, K; Oya, M; Shinoda, K; Tanaka, N; Umezawa, K1
Abe, R; Hamasaka, A; Kishino, S; Ozaki, M; Shimizu, H; Todo, S; Umezawa, K; Yoshioka, N1
Furukawa, H; Kamachi, H; Kasai, H; Matsumoto, S; Matsushita, M; Ozaki, M; Takahashi, T; Todo, S; Tsuruga, Y; Umezawa, K; Watanabe, M1
Higashihara, M; Horie, R; Ishii, Y; Nakashima, M; Togano, T; Umezawa, K; Watanabe, M; Watanabe, T1
Ishikawa, Y; Nishiyama, S; Obata, R; Ohba, S; Saitoh, T; Shiino, M; Shimada, C; Takeiri, M; Umezawa, K1
Ishida, S; Kato, N; Kubota, M; Kubota, S; Kurihara, T; Miyashita, H; Noda, K; Ozawa, Y; Shimmura, S; Tsubota, K; Umezawa, K; Usui, T1
Kobayashi, K; Umezawa, K; Yasui, M1
Ninomiya, Y; Shimada, C; Suzuki, E; Umezawa, K1
Bobb, K; Datta, D; Jacobson, S; McCormick, MJ; Meshulam, J; Monie, DD; Oh, U; Sliskovic, DR; Tanaka, Y; Turner, RV; Zhang, J1
Haga, S; Kamiyama, T; Kataoka, A; Kina, M; Mino, K; Nakanishi, K; Ochiya, T; Ozaki, M; Sato, M; Takahashi, M; Takahashi, N; Todo, S; Umezawa, K; Yanagihara, K1
Kondo, S; Mukudai, Y; Nagumo, T; Shintani, S; Tsukamoto, H; Umezawa, K; Yasuda, A1
Goto, Y; Hakamata, M; Higashi, T; Niitsu, Y; Shoji, M; Sugai, T; Umezawa, K1
Ishida, T; Izawa, K; Kobayashi, S; Lin, SF; Tojo, A; Tsai, HJ; Umezawa, K; Watanabe, T1
Gotoh, Y; Ishikawa, Y; Nishiyama, S; Saitoh, T; Takeiri, M; Umezawa, K1
Isshiki, M; Tamura, H; Umezawa, K1
Fukushima, T; Kataoka, H; Kawaguchi, M; Takeshima, H; Tanaka, H; Umezawa, K; Yorita, K1
Adachi, Y; Ikehara, S; Kaneko, K; Okigaki, M; Shimo, T; Takaya, J; Taniuchi, S; Umezawa, K1
Alberti, C; Canevari, S; Ditto, A; Ferri, R; Pinciroli, P; Sensi, M; Tomassetti, A; Umezawa, K; Valeri, B1
Gondo, T; Horiguchi, Y; Nakashima, J; Ohno, Y; Tachibana, M; Takeuchi, H1
Fukai, M; Funakoshi, T; Goto, R; Ichihara, S; Ichikawa, N; Katsurada, T; Kobayashi, N; Oura, T; Ozaki, M; Suzuki, T; Todo, S; Umezawa, K; Yamashita, K1
Azzolina, A; Cervello, M; Lampiasi, N; McCubrey, JA; Montalto, G; Umezawa, K1
Aoyagi, T; Goto, R; Hirokata, G; Igarashi, R; Kobayashi, N; Oura, T; Ozaki, M; Shibasaki, S; Shibata, T; Todo, S; Ueki, S; Umezawa, K; Uno, M; Wakayama, K; Yamashita, K; Zaitsu, M1
Borges, KS; Castro-Gamero, AM; da Silva Silveira, V; de Paula Gomes Queiroz, R; Lira, RC; Scrideli, CA; Tone, LG; Umezawa, K; Valera, FC1
Horie, K; Horie, R; Simizu, S; Takahashi, D; Takeiri, M; Umezawa, K; Watanabe, M1
Kabe, Y; Kambayashi, Y; Noma, N; Simizu, S; Suematsu, M; Umezawa, K1
Anselmo-Lima, WT; Brassesco, MS; Castro-Gamero, AM; Queiroz, RG; Scrideli, CA; Tone, LG; Umezawa, K; Valera, FC1
Hasegawa, M; Horiguchi, Y; Ide, H; Kikuchi, E; Kozakai, N; Miyajima, A; Nakashima, J; Oya, M; Shigematsu, N; Suzuki, E; Umezawa, K1
Konno, S; Nishimura, M; Ozaki, M; Shimizu, K; Todo, S; Umezawa, K; Yamashita, K1
Hanaya, K; Kobayashi, R; Shoji, M; Sugai, T; Umezawa, K1
Aiura, K; Itano, O; Kitagawa, Y; Matsuda, S; Suzuki, K; Takeuchi, O; Umezawa, K1
Goto, R; Haga, S; Igarashi, R; Ozaki, M; Shibasaki, S; Todo, S; Tsunetoshi, Y; Umezawa, K; Wakayama, K; Yamashita, K; Zaitsu, M1
Belmadani, S; Bishop, A; Choi, SK; Galán, M; Kassan, M; Matrougui, K; Trebak, M; Umezawa, K1
Ito, A; Kawai, T; Ogasawara, A; Saisho, Y; Simizu, S; Takei, I; Umezawa, K1
Kojima, I; Sidthipong, K; Takei, I; Todo, S; Umezawa, K1
Adachi, Y; Ikehara, S; Kaneko, K; Kimata, T; Okigaki, M; Shimo, T; Takaya, J; Tsuji, S; Umezawa, K; Yamanouchi, S1
Gu, L; Johno, H; Kato, H; Kitamura, M; Nakajima, S; Takahashi, S; Umezawa, K1
Asahi, Y; Emoto, S; Kamachi, H; Koshizuka, Y; Kuraya, D; Matsushita, M; Ogura, M; Ono, H; Ozaki, M; Shibasaki, S; Todo, S; Umezawa, K; Watanabe, M; Yamashita, K; Yoshida, T1
Asahi, Y; Harashima, H; Kamachi, H; Koshizuka, Y; Kuraya, D; Matsushita, M; Nakamura, T; Ogura, M; Ozaki, M; Todo, S; Umezawa, K; Watanabe, M; Yamashita, K; Yoshida, T1
Ito, S; Koike, R; Komatsu, S; Kubota, T; Miyasaka, N; Shimogaki, S; Umezawa, K1
Higashihara, M; Horie, R; Itoh, K; Masuda, N; Togano, T; Umezawa, K; Watanabe, M1
Imamura, Y; Nagumo, S; Nakago, T; Takayama, K; Takeda, N; Yasui, E1
Belmadani, S; Choi, SK; Galán, M; Kassan, M; Matrougui, K; Trebak, M1
Aldinucci, D; Borghese, C; Carbone, A; Casagrande, N; Celegato, M; Colombatti, A; Umezawa, K1
Miyagi, T; Miyoshi, R; Ochiya, T; Oka, T; Shiotani, B; Tahara, H; Takano, M; Umezawa, K; Yamamoto, T1
Higashihara, M; Horie, R; Umezawa, K; Watanabe, M1
Aoki, D; Fujii, T; Iwata, T; Kawakami, Y; Kawamura, N; Kobayashi, A; Nishio, H; Park, J; Sugiyama, J; Sumimoto, H; Susumu, N; Umezawa, K; Yaguchi, T1
Baird, AM; Barr, MP; Cuffe, S; Finn, SP; Gately, K; Godwin, P; Heavey, S; O'Byrne, KJ; Umezawa, K1
Chaiyagool, J; Hahnvajanawong, C; Khuntikeo, N; Okada, S; Puapairoj, A; Pugkhem, A; Seubwai, W; Umezawa, K; Wongkham, C; Wongkham, S1
Baba, M; Fujiyoshi, M; Haga, S; Kamiyama, T; Mino, K; Nakanishi, K; Niwa, H; Ohmiya, Y; Ozaki, M; Sato, M; Taketomi, A; Todo, S; Umezawa, K; Yokoo, H1
Lian, A; Shi, Z; Zhang, F1
Fukuda, K; Fukushima, A; Hirakata, A; Inokawa, S; Keino, H; Okada, AA; Sato, Y; Umezawa, K; Watanabe, T1
Chen, TX; Jin, YY; Tian, ZQ; Wang, LL; Wang, XF; Wang, Z; Yang, WT; Yao, CM; Zhang, H1
Horie, K; Ma, J; Umezawa, K1
Asagiri, M; Iwaisako, K; Maeda-Yamamoto, M; Minato, N; Noma, N; Ohmae, S; Simizu, S; Takeiri, M; Takemoto, K; Umezawa, K1
Adachi, Y; Ikehara, S; Kaneko, K; Kuge, T; Li, M; Okigaki, M; Shimo, T; Takaya, J; Tsuji, S; Umezawa, K; Yamanouchi, S1
Kraiklang, R; Okada, S; Seubwai, W; Umezawa, K; Vaeteewoottacharn, K; Wongkham, S1
El-Salhy, M; Umezawa, K3
Fukushima, T; Kanemaru, A; Kataoka, H; Kawaguchi, M; Tanaka, H; Umezawa, K; Yamamoto, K1
Lin, Y; Okada, S; Ukaji, T; Umezawa, K1
D'Alessandro, N; Labbozzetta, M; Notarbartolo, M; Poma, P1
Dai, C; Gu, Y; Jiang, X; Lan, Y; Liu, X; Ma, J; Umezawa, K; Wei, B; Zhang, Y1
Benkisser-Petersen, M; Bleckmann, D; Burger, M; Claus, R; Decker, S; Dierks, C; Duyster, J; Foerster, K; Saleem, S; Simon-Gabriel, CP; Thornton, N; Umezawa, K; Veelken, H; Zirlik, K1
Castro-Gamero, AM; Oliveira, HF; Pezuk, JA; Ramos, PMM; Scrideli, CA; Tone, LG; Umezawa, K1
Koide, N; Lin, Y; Ukaji, T; Umezawa, K1
Fukatsu, H; Ichihara, S; Ikegami, A; Izuoka, K; Koide, N; Komatsu, T; Morita, N; Naiki, Y; Tada-Oikawa, S; Ukaji, T; Umezawa, K1
Gao, X; He, H; Jiang, X; Li, X; Ma, J; Ma, K; Umezawa, K; Wang, X; Xie, Z; Zhang, Y1
Ando, Y; Hirakata, A; Keino, H; Kudo, A; Okada, AA; Umezawa, K1
Chang, HW; Chiou, HY; Hsueh, CS; Jeng, CR; Pang, VF; Shih, CH; Wu, CH; Yeh, JL1
Lin, Y; Umezawa, K1
Ando, Y; Hirakata, A; Keino, H; Kudo, A; Okada, AA; Sato, Y; Umezawa, K; Watanabe, T1
He, X; Li, W; Li, X; Ma, J; Niu, N; Tao, H; Xia, Y; Xu, J; Xu, X1
Breborowicz, A; Gantsev, S; Umezawa, K1
Asanuma, H; Kanno, Y; Kono, H; Mizuno, R; Morita, S; Nakagawa, K; Oya, M; Shimoda, M; Shinoda, K; Umezawa, K; Yoshida, T1
El-Salhy, M; Keino, H; Kubota, T; Ma, J; Ozaki, M; Sugai, T; Umezawa, K; Zhang, Y1
Abe, Y; Fujisaki, H; Hasegawa, Y; Hori, S; Ishihara, K; Itano, O; Kishino, S; Kitagawa, Y; Kitago, M; Konno, T; Matsuda, S; Nakano, Y; Ohno, K; Suzuki, K; Tanaka, M; Umezawa, K; Yagi, H1

Reviews

15 review(s) available for tiletamine hydrochloride and dehydroxymethylepoxyquinomicin

ArticleYear
Molecular design and biological activities of NF-kappaB inhibitors.
    Molecules and cells, 2002, Oct-31, Volume: 14, Issue:2

    Topics: Animals; Benzamides; Cyclohexanones; Drug Design; Humans; Mice; NF-kappa B; Signal Transduction

2002
Antitumor effect of a novel nuclear factor-kappa B activation inhibitor in bladder cancer cells.
    Expert review of anticancer therapy, 2003, Volume: 3, Issue:6

    Topics: Animals; Antineoplastic Agents; Benzamides; Cyclohexanones; Humans; NF-kappa B; Urinary Bladder Neoplasms

2003
Blocking NF-kappaB as a potential strategy to treat adult T-cell leukemia/lymphoma.
    Drug news & perspectives, 2006, Volume: 19, Issue:4

    Topics: Adult; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cyclohexanones; Humans; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, T-Cell; NF-kappa B

2006
Inhibition of tumor growth by NF-kappaB inhibitors.
    Cancer science, 2006, Volume: 97, Issue:10

    Topics: Animals; Antineoplastic Agents; Benzamides; Cell Proliferation; Cyclohexanones; Drug Design; Humans; Neoplasms; NF-kappa B; Quinones; Signal Transduction; Tumor Cells, Cultured

2006
[Clinical and hematological characteristics of adult T-cell leukemia/lymphoma].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2006, Volume: 47, Issue:12

    Topics: Benzamides; Boronic Acids; Bortezomib; Carrier State; Cyclohexanones; HIV Protease Inhibitors; Human T-lymphotropic virus 1; Humans; Infectious Disease Transmission, Vertical; Leukemia-Lymphoma, Adult T-Cell; NF-kappa B; Protease Inhibitors; Pyrazines; Ritonavir; Stem Cell Transplantation; Transplantation, Homologous

2006
Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer.
    Arquivos brasileiros de endocrinologia e metabologia, 2007, Volume: 51, Issue:5

    Topics: Animals; Apoptosis; Benzamides; Carcinoma; Cyclohexanones; Enzyme Activation; Humans; Inhibitor of Apoptosis Proteins; JNK Mitogen-Activated Protein Kinases; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Signal Transduction; Thyroid Neoplasms; Transcriptional Activation

2007
[Screening of bioactive metabolites that suppress inflammation].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007, Volume: 52, Issue:13 Suppl

    Topics: Animals; Anti-Inflammatory Agents; Benzamides; Biological Products; Cell Differentiation; Cyclohexanones; Depsipeptides; Drug Design; Drug Evaluation, Preclinical; Inflammation; Inflammation Mediators; Lipopolysaccharides; Neoplasms; NF-kappa B; Osteoclasts; Piperidones; Signal Transduction

2007
Chemosensitization and immunosensitization of resistant cancer cells to apoptosis and inhibition of metastasis by the specific NF-kappaB inhibitor DHMEQ.
    Current pharmaceutical design, 2009, Volume: 15, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Line, Tumor; Cyclohexanones; Drug Resistance, Neoplasm; Humans; Neoplasm Metastasis; Neoplasms; NF-kappa B

2009
Possible role of peritoneal NF-κB in peripheral inflammation and cancer: lessons from the inhibitor DHMEQ.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2011, Volume: 65, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cyclohexanones; Humans; Inflammation; Molecular Structure; Neoplasms; NF-kappa B; Peritoneum

2011
[NF-kappaB inhibitor].
    Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69 Suppl 5

    Topics: Antineoplastic Agents; Benzamides; Cyclohexanones; Glucocorticoids; Humans; Male; NF-kappa B; Prostatic Neoplasms; Proteasome Inhibitors; Pyrrolidines; Thiocarbamates

2011
Screening of new bioactive metabolites for diabetes therapy.
    Internal and emergency medicine, 2013, Volume: 8 Suppl 1

    Topics: Animals; Benzamides; Cell Differentiation; Cyclohexanones; Diabetes Mellitus, Type 1; Fibrosis; Humans; Insulin-Secreting Cells; Islets of Langerhans Transplantation; NF-kappa B; Vinca Alkaloids

2013
Inhibition of Late and Early Phases of Cancer Metastasis by the NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review.
    International journal of molecular sciences, 2018, Mar-03, Volume: 19, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzamides; Cyclohexanones; Humans; Neoplasm Metastasis; Neoplasms; NF-kappa B; Quinones

2018
Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin.
    Biochimica et biophysica acta. Proteins and proteomics, 2020, Volume: 1868, Issue:6

    Topics: Actinobacteria; Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Movement; Cyclohexanones; Glyoxylates; Humans; Matrix Metalloproteinase 11; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Models, Molecular; Neoplasm Invasiveness; Neoplasms; NF-kappa B; NF-kappa B p50 Subunit; Quinones

2020
Anticancer Activity of Novel NF-kappa B Inhibitor DHMEQ by Intraperitoneal Administration.
    Oncology research, 2020, 12-10, Volume: 28, Issue:5

    Topics: Animals; Antineoplastic Agents; Benzamides; Breast Neoplasms; Cyclohexanones; Female; Humans; Injections, Intraperitoneal; Lymphoma; Male; Mice; Multiple Myeloma; Neoplasms; NF-kappa B

2020
Inhibition of Cellular and Animal Inflammatory Disease Models by NF-κB Inhibitor DHMEQ.
    Cells, 2021, 09-01, Volume: 10, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Benzamides; Cyclohexanones; Disease Models, Animal; Humans; Inflammation; Mice; NF-kappa B

2021

Other Studies

133 other study(ies) available for tiletamine hydrochloride and dehydroxymethylepoxyquinomicin

ArticleYear
Inhibition of tumor necrosis factor-alpha -induced nuclear translocation and activation of NF-kappa B by dehydroxymethylepoxyquinomicin.
    The Journal of biological chemistry, 2002, Jul-05, Volume: 277, Issue:27

    Topics: Active Transport, Cell Nucleus; Apoptosis; Benzamides; Cyclohexanones; DNA-Binding Proteins; Genes, Reporter; Green Fluorescent Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Luminescent Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Smad2 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha

2002
Synthesis and structure-activity relationship of dehydroxymethylepoxyquinomicin analogues as inhibitors of NF-kappaB functions.
    Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:12

    Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Benzamides; Cyclohexanones; Dose-Response Relationship, Drug; Humans; Jurkat Cells; NF-kappa B; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2002
Suppression of hormone-refractory prostate cancer by a novel nuclear factor kappaB inhibitor in nude mice.
    Cancer research, 2003, Jan-01, Volume: 63, Issue:1

    Topics: Animals; Apoptosis; Benzamides; Cell Division; Cyclohexanones; Dose-Response Relationship, Drug; Drug Resistance; Humans; Kinetics; Male; Mice; Mice, Nude; NF-kappa B; Prostatic Neoplasms; Tumor Cells, Cultured

2003
Novel nuclear factor kappa B activation inhibitor prevents inflammatory injury in unilateral ureteral obstruction.
    The Journal of urology, 2003, Volume: 169, Issue:4

    Topics: Animals; Apoptosis; Benzamides; Cell Division; Cyclohexanones; Fibrosis; In Situ Nick-End Labeling; Leukocyte Common Antigens; Leukocyte Count; NF-kappa B; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Ureter; Ureteral Obstruction

2003
Preparation of radioactively labeled dehydroxymethyl-epoxyquinomicin, an NF-kappa B function inhibitor.
    Drugs under experimental and clinical research, 2003, Volume: 29, Issue:1

    Topics: Benzamides; Cyclohexanones; Isotope Labeling; NF-kappa B; Tritium

2003
Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, dehydroxymethylepoxyquinomicin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Oct-15, Volume: 10, Issue:20

    Topics: Apoptosis; Benzamides; Carcinoma; Cyclohexanones; Humans; NF-kappa B; Thyroid Neoplasms; Tumor Cells, Cultured

2004
A novel NF-kappaB inhibitor DHMEQ selectively targets constitutive NF-kappaB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo.
    International journal of cancer, 2005, Mar-10, Volume: 114, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Benzamides; Calcium-Binding Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Line, Tumor; Cyclin D; Cyclin D1; Cyclins; Cyclohexanones; Disease Models, Animal; Down-Regulation; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Mice; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma; Nerve Tissue Proteins; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Synaptotagmin I; Synaptotagmins; Translocation, Genetic; Vascular Endothelial Growth Factor A

2005
Targeting of nuclear factor kappaB Pathways by dehydroxymethylepoxyquinomicin, a novel inhibitor of breast carcinomas: antitumor and antiangiogenic potential in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Feb-01, Volume: 11, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Breast Neoplasms; Cell Line, Tumor; Cyclohexanones; Dose-Response Relationship, Drug; Doxorubicin; Female; Humans; Interleukin-6; Interleukin-8; Lymphotoxin-alpha; Male; Mice; Mice, Inbred BALB C; Mice, SCID; NF-kappa B; Phosphorylation; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays

2005
Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2005, Volume: 20, Issue:4

    Topics: Animals; Benzamides; Bone Marrow Cells; Bone Resorption; Carrier Proteins; Cell Differentiation; Cyclohexanones; Down-Regulation; Macrophages; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Molecular Structure; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Phosphorylation; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B

2005
In vivo antitumor activity of the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin in a mouse model of adult T-cell leukemia.
    Carcinogenesis, 2005, Volume: 26, Issue:8

    Topics: Animals; Antineoplastic Agents; Apoptosis; Base Sequence; Benzamides; Binding Sites; Cell Division; Cell Line, Tumor; Consensus Sequence; Cyclohexanones; Disease Models, Animal; Human T-lymphotropic virus 1; Humans; Leukemia-Lymphoma, Adult T-Cell; Mice; NF-kappa B; Transplantation, Heterologous

2005
Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-kappaB inhibitor.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2005, Volume: 59, Issue:6

    Topics: Animals; Benzamides; Cell Line; Cyclohexanones; Cytokines; Dose-Response Relationship, Drug; Interleukin-6; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Tumor Necrosis Factor-alpha

2005
Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia.
    Blood, 2005, Oct-01, Volume: 106, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Caspases; Cell Cycle; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Reporter; Human T-lymphotropic virus 1; Humans; Immunoblotting; Immunohistochemistry; Jurkat Cells; K562 Cells; Leukemia-Lymphoma, Adult T-Cell; Leukemia, T-Cell; Leukocytes, Mononuclear; Male; Mice; Mice, SCID; Microscopy, Fluorescence; Molecular Weight; NF-kappa B; Proviruses; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Time Factors; Tumor Suppressor Protein p53

2005
In vitro and in vivo antitumor activity of the NF-kappaB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line, HUT-102.
    Leukemia research, 2006, Volume: 30, Issue:1

    Topics: Active Transport, Cell Nucleus; Animals; Benzamides; Cell Line; Cell Nucleus; Cyclohexanones; Human T-lymphotropic virus 1; Humans; Leukemia-Lymphoma, Adult T-Cell; Mice; Mice, SCID; Neoplasm Proteins; Neoplasm Transplantation; Transcription Factor RelA

2006
Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, induces apoptosis in multiple myeloma cells in an IkappaBalpha-independent manner.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Caspases; Cyclin D1; Cyclohexanones; Down-Regulation; Drug Screening Assays, Antitumor; Enzyme Activation; Female; Humans; I-kappa B Proteins; Mice; Mice, Inbred ICR; Mice, SCID; Minor Histocompatibility Antigens; Multiple Myeloma; NF-kappa B; NF-KappaB Inhibitor alpha; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured

2005
Prevention of cancer cachexia by a novel nuclear factor {kappa}B inhibitor in prostate cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Aug-01, Volume: 11, Issue:15

    Topics: Albumins; Animals; Antineoplastic Agents; Benzamides; Body Mass Index; Body Weight; Cachexia; Cell Line, Tumor; Cyclohexanones; Disease Models, Animal; Dose-Response Relationship, Drug; Hematocrit; Humans; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Neoplasm Transplantation; NF-kappa B; Prostatic Neoplasms; Time Factors; Triglycerides; Weight Loss

2005
Enhancement of the caspase-independent apoptotic sensitivity of pancreatic cancer cells by DHMEQ, an NF-kappaB inhibitor.
    International journal of oncology, 2005, Volume: 27, Issue:5

    Topics: Apoptosis; Benzamides; Caspase 3; Caspases; Cell Survival; Cyclohexanones; Drug Interactions; Humans; Kinetics; Mitochondria; Pancreatic Neoplasms; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation

2005
Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells.
    Arthritis research & therapy, 2005, Volume: 7, Issue:6

    Topics: Animals; Arthritis, Experimental; Benzamides; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cyclohexanones; Disease Models, Animal; Hindlimb; Humans; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; NF-kappa B; RNA, Messenger; Synovial Membrane; Translocation, Genetic

2005
Effects of a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on growth, apoptosis, gene expression, and chemosensitivity in head and neck squamous cell carcinoma cell lines.
    Head & neck, 2006, Volume: 28, Issue:2

    Topics: Apoptosis; Benzamides; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclohexanones; Gene Expression; Head and Neck Neoplasms; Humans; NF-kappa B; Vascular Endothelial Growth Factor A

2006
DHMEQ, a new NF-kappaB inhibitor, induces apoptosis and enhances fludarabine effects on chronic lymphocytic leukemia cells.
    Leukemia, 2006, Volume: 20, Issue:5

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Benzamides; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspases; CD40 Antigens; Cell Line, Tumor; Cell Survival; Cyclohexanones; Down-Regulation; Drug Synergism; Female; Humans; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Minor Histocompatibility Antigens; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Vidarabine

2006
Survivin associates with cell proliferation in renal cancer cells: regulation of survivin expression by insulin-like growth factor-1, interferon-gamma and a novel NF-kappaB inhibitor.
    International journal of oncology, 2006, Volume: 28, Issue:4

    Topics: Benzamides; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Insulin-Like Growth Factor I; Interferon-gamma; Kidney Neoplasms; Microtubule-Associated Proteins; Neoplasm Proteins; NF-kappa B; RNA Interference; RNA, Small Interfering; Survivin; Transfection

2006
Antitumor effects of the novel NF-kappaB inhibitor dehydroxymethyl-epoxyquinomicin on human hepatic cancer cells: analysis of synergy with cisplatin and of possible correlation with inhibition of pro-survival genes and IL-6 production.
    International journal of oncology, 2006, Volume: 28, Issue:4

    Topics: Antineoplastic Agents; bcl-X Protein; Benzamides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cisplatin; Cyclohexanones; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Interleukin-6; Liver Neoplasms; Neuronal Apoptosis-Inhibitory Protein; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

2006
DHMEQ, a novel NF-kappaB inhibitor, induces apoptosis and cell-cycle arrest in human hepatoma cells.
    International journal of oncology, 2006, Volume: 29, Issue:3

    Topics: Animals; Apoptosis; bcl-X Protein; Benzamides; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cyclohexanones; Electrophoretic Mobility Shift Assay; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Tumor Necrosis Factor-alpha

2006
Inhibition of macrophage activation and phagocytosis by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2006, Volume: 60, Issue:9

    Topics: Animals; Benzamides; Cells, Cultured; Cyclohexanones; Cytokines; Lipopolysaccharides; Macrophage Activation; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phagocytosis; Toll-Like Receptor 4

2006
A selective NFkappaB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient mice.
    Journal of atherosclerosis and thrombosis, 2006, Volume: 13, Issue:6

    Topics: Adiponectin; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Benzamides; Body Weight; Cholesterol; Cyclohexanones; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Triglycerides; Tumor Necrosis Factor-alpha

2006
Control of allograft rejection by applying a novel nuclear factor-kappaB inhibitor, dehydroxymethylepoxyquinomicin.
    Transplantation, 2006, Dec-27, Volume: 82, Issue:12

    Topics: Animals; Antibodies, Monoclonal; Benzamides; CD28 Antigens; CD3 Complex; Cyclohexanones; Drug Therapy, Combination; Graft Rejection; Immunosuppression Therapy; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Mice, Inbred Strains; NF-kappa B; Protein Transport; T-Lymphocytes; Tacrolimus

2006
Significance of autologous interleukin-6 production in the HA22T/VGH cell model of hepatocellular carcinoma.
    Annals of the New York Academy of Sciences, 2006, Volume: 1089

    Topics: Antibodies; Benzamides; Carcinoma, Hepatocellular; Cell Membrane; Curcumin; Cyclohexanones; Cytokine Receptor gp130; Humans; Interleukin-6; Liver Neoplasms; Models, Biological; NF-kappa B; Receptors, Interleukin-6; RNA, Small Interfering; Tumor Cells, Cultured

2006
IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells.
    Laboratory investigation; a journal of technical methods and pathology, 2007, Volume: 87, Issue:4

    Topics: Animals; Apoptosis; Benzamides; Caspases; Cell Line; Cyclohexanones; Daunorubicin; Enzyme Activation; Etoposide; Hodgkin Disease; Humans; I-kappa B Kinase; I-kappa B Proteins; Leukocytes, Mononuclear; Mice; Mutation; Neoplasm Transplantation; NF-kappa B; NF-KappaB Inhibitor alpha; Reed-Sternberg Cells; Topoisomerase Inhibitors; Transplantation, Heterologous; Tumor Cells, Cultured

2007
Targeting NF-kappaB and induction of apoptosis by novel NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells.
    Leukemia research, 2007, Volume: 31, Issue:11

    Topics: Apoptosis; Benzamides; Burkitt Lymphoma; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Enzyme Activation; Humans; NF-kappa B; Phosphorylation

2007
Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway.
    Investigative ophthalmology & visual science, 2007, Volume: 48, Issue:9

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Benzamides; Blotting, Western; Cell Adhesion; Chemokine CCL2; Cyclohexanones; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Imidazoles; Intercellular Adhesion Molecule-1; Leukocytes; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pyridines; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Retinitis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Thiazolidines; Valine; Valsartan; Vascular Endothelial Growth Factor A

2007
Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with tax-deficient adult T-cell leukemia-derived cell lines.
    Cancer letters, 2007, Nov-18, Volume: 257, Issue:2

    Topics: Adult; Animals; Apoptosis; Benzamides; beta 2-Microglobulin; Cell Line, Tumor; Cyclohexanones; Gene Products, tax; Human T-lymphotropic virus 1; Humans; Leukemia, T-Cell; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Analysis; Tumor Burden; Xenograft Model Antitumor Assays

2007
Inhibition of cellular adhesion in human umbilical vein endothelial cells by NF-kappaB inhibitor DHMEQ under flow.
    Oncology research, 2005, Volume: 15, Issue:4

    Topics: Benzamides; Biomechanical Phenomena; Blotting, Western; Cell Adhesion; Cell Culture Techniques; Cells, Cultured; Cyclohexanones; Electrophoretic Mobility Shift Assay; Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Leukocytes; NF-kappa B; Tumor Necrosis Factor-alpha; Umbilical Veins

2005
NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor.
    Arthritis research & therapy, 2007, Volume: 9, Issue:5

    Topics: Aged; Animals; Arthritis, Experimental; Benzamides; Cells, Cultured; Cyclohexanones; Female; Gene Expression Regulation; Humans; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred DBA; Middle Aged; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteoprotegerin; RANK Ligand

2007
DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic cells.
    Immunology, 2008, Volume: 124, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Benzamides; Cell Differentiation; Cell Proliferation; Cyclohexanones; Cytokines; Dendritic Cells; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endocytosis; Humans; Jurkat Cells; Leukocytes, Mononuclear; Lymphocyte Culture Test, Mixed; Phytohemagglutinins; Th1 Cells

2008
Effects of DHMEQ, a novel nuclear factor-kappab inhibitor, on beta cell dysfunction in INS-1 cells.
    Endocrine journal, 2008, Volume: 55, Issue:2

    Topics: Animals; Benzamides; Cell Line, Tumor; Cell Survival; Cyclohexanones; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin-Secreting Cells; Insulinoma; NF-kappa B; Pancreatic Neoplasms; Rats; Tumor Necrosis Factor-alpha

2008
DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts.
    Journal of dermatological science, 2008, Volume: 51, Issue:3

    Topics: Benzamides; Cell Division; Cells, Cultured; Collagen Type I; Cyclohexanones; DNA; Fibroblasts; Humans; Immunohistochemistry; Keloid; NF-kappa B; Transcription Factor RelA

2008
Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-kappaB inhibitor DHMEQ.
    Microbes and infection, 2008, Volume: 10, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Benzamides; Cell Line, Tumor; Cell Survival; Cyclohexanones; Herpesvirus 4, Human; Humans; Immunologic Factors; Lymphoproliferative Disorders; Mice; Mice, SCID; NF-kappa B

2008
The novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reperfusion in rats.
    The Journal of surgical research, 2008, Volume: 149, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Benzamides; Cyclohexanones; Disease Models, Animal; Intestinal Diseases; Lung Diseases; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2008
A simple and reliable method for determining plasma concentration of dehydroxymethylepoxyquinomicin by high performance liquid chromatography with mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Aug-01, Volume: 871, Issue:1

    Topics: Animals; Benzamides; Calibration; Chromatography, High Pressure Liquid; Cyclohexanones; Humans; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Reproducibility of Results; Sensitivity and Specificity

2008
Inhibition of inflammatory mediator secretion by (-)-DHMEQ in mouse bone marrow-derived macrophages.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2009, Volume: 63, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Blotting, Western; Cell Differentiation; Cell Line; Cyclohexanones; Cyclooxygenase 2; Cytokines; Electrophoretic Mobility Shift Assay; Lipopolysaccharides; Lipoproteins, LDL; Macrophages; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Stereoisomerism

2009
Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells.
    Endocrinology, 2008, Volume: 149, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Carcinoma; Cyclohexanones; Drug Synergism; Genes, p53; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Biological; NF-kappa B; Peptides; Taxoids; Thyroid Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2008
The novel NF-kappaB activation inhibitor dehydroxymethyl-epoxyquinomicin suppresses anti-Thy1.1-induced glomerulonephritis in rats.
    Nephron. Experimental nephrology, 2008, Volume: 110, Issue:1

    Topics: Animals; Antibodies; Benzamides; Cell Proliferation; Cyclohexanones; Glomerulonephritis, Membranoproliferative; Kidney Glomerulus; NF-kappa B; Rats; Thy-1 Antigens

2008
Inactivation of NF-kappaB components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues.
    Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18

    Topics: Animals; Base Sequence; Benzamides; Binding Sites; Cell Line, Tumor; Cyclohexanones; Cysteine; DNA Primers; Electrophoretic Mobility Shift Assay; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mutagenesis, Site-Directed; NF-kappa B; Surface Plasmon Resonance

2008
Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ).
    Cancer letters, 2008, Dec-18, Volume: 272, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Nucleus; Cyclohexanones; Humans; Microscopy, Confocal; NF-kappa B; Protein Transport; Sarcoma, Synovial

2008
Identification of the RelA domain responsible for action of a new NF-kappaB inhibitor DHMEQ.
    Biochemical and biophysical research communications, 2008, Nov-14, Volume: 376, Issue:2

    Topics: Amino Acid Sequence; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Benzamides; Cell Nucleus; Cyclohexanones; Cysteine; HeLa Cells; Humans; Protein Structure, Tertiary; Sequence Deletion; Transcription Factor RelA

2008
The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs.
    Leukemia & lymphoma, 2008, Volume: 49, Issue:10

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Apoptosis; Benzamides; Boronic Acids; Bortezomib; Cell Line, Tumor; Cyclohexanones; Drug Resistance, Neoplasm; Humans; Lymphoma, AIDS-Related; Lymphoma, B-Cell; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Rituximab

2008
Induction of histidine decarboxylase in macrophages inhibited by the novel NF-kappaB inhibitor (-)-DHMEQ.
    Biochemical and biophysical research communications, 2009, Feb-06, Volume: 379, Issue:2

    Topics: Animals; Benzamides; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Cell Nucleus; Cyclohexanones; Histamine; Histidine Decarboxylase; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Transcription Factor RelA; Transcriptional Activation

2009
Antitumor effects of dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, in human liver cancer cells are mediated through a reactive oxygen species-dependent mechanism.
    Molecular pharmacology, 2009, Volume: 76, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Benzamides; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinases; NF-kappa B; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species

2009
Transient inhibition of NF-kappaB by DHMEQ induces cell death of primary effusion lymphoma without HHV-8 reactivation.
    Cancer science, 2009, Volume: 100, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Caspase 8; Caspase 9; Cell Death; Cell Line, Tumor; Cell Survival; Cyclohexanones; Dose-Response Relationship, Drug; Enzyme Activation; HeLa Cells; Herpesvirus 8, Human; Humans; In Situ Nick-End Labeling; Jurkat Cells; K562 Cells; Lymphoma, Primary Effusion; NF-kappa B; Time Factors

2009
A small molecule inhibitor of NF-kappaB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells.
    Cancer letters, 2010, Jan-01, Volume: 287, Issue:1

    Topics: Apoptosis; Benzamides; Cell Division; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclohexanones; G2 Phase; Humans; Intercellular Adhesion Molecule-1; Matrix Metalloproteinase 9; Nasopharyngeal Neoplasms; Neoplasm Invasiveness; NF-kappa B; Vascular Endothelial Growth Factor A

2010
Efficient synthesis of (+/-)-parasitenone, a novel inhibitor of NF-kappaB.
    Bioorganic & medicinal chemistry letters, 2009, Sep-15, Volume: 19, Issue:18

    Topics: Animals; Benzamides; Cell Line; Cell Proliferation; Cell Survival; Cyclohexanones; Epoxy Compounds; Macrophages; Mice; NF-kappa B; Nitric Oxide

2009
Unusual intramolecular N-->O acyl group migration occurring during conjugation of (-)-DHMEQ with cysteine.
    Bioorganic & medicinal chemistry letters, 2009, Sep-15, Volume: 19, Issue:18

    Topics: Benzamides; Cyclohexanones; Cysteine; Molecular Conformation; NF-kappa B

2009
Impairment of plasmacytoid dendritic cells for IFN production by the ligand for immunoglobulin-like transcript 7 expressed on human cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Sep-15, Volume: 15, Issue:18

    Topics: Animals; Benzamides; Chlorocebus aethiops; COS Cells; Cyclohexanones; Cytokines; Dendritic Cells; Humans; Interferon-gamma; Ligands; Oligodeoxyribonucleotides; Receptors, IgE; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2009
Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome.
    Annals of the New York Academy of Sciences, 2009, Volume: 1173

    Topics: Antiphospholipid Syndrome; Autoantibodies; Benzamides; beta 2-Glycoprotein I; Blood Platelets; Cell Line; Cells, Cultured; Chemokine CCL5; Chemokine CX3CL1; Chemokines; Cyclohexanones; Disease Susceptibility; Enzyme-Linked Immunosorbent Assay; Gene Expression; Humans; Leukocytes, Mononuclear; Platelet Activation; Platelet Aggregation; Reverse Transcriptase Polymerase Chain Reaction; Thromboplastin; Thrombosis

2009
Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.
    Biochemical and biophysical research communications, 2009, Dec-04, Volume: 390, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Benzamides; Camptothecin; Cell Line, Tumor; Cyclohexanones; Drug Resistance, Neoplasm; Humans; Neoplasms; NF-kappa B; Oncogenes

2009
Characterizing the involvement of the nuclear factor-kappa B (NF kappa B) transcription factor in uveal melanoma.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:4

    Topics: Apoptosis; Benzamides; Blotting, Western; Caspase 3; Cell Proliferation; Cyclohexanones; Fluorescent Antibody Technique, Indirect; Humans; Imidazoles; Ki-67 Antigen; Liver Neoplasms; Melanoma; NF-kappa B; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Uveal Neoplasms

2010
Amelioration of experimental autoimmune uveoretinitis with nuclear factor-{kappa}B Inhibitor dehydroxy methyl epoxyquinomicin in mice.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:4

    Topics: Animals; Antigen-Presenting Cells; Autoimmune Diseases; Benzamides; Cell Nucleus; Cyclohexanones; Cytokines; Disease Models, Animal; Down-Regulation; Female; Fluorescent Antibody Technique, Indirect; Injections, Intraperitoneal; Lymphocyte Activation; Mice; Microscopy, Confocal; Retina; Retinitis; T-Lymphocytes; Transcription Factor RelA; Uveitis

2010
Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells.
    British journal of cancer, 2010, Jan-05, Volume: 102, Issue:1

    Topics: Animals; Benzamides; Biomarkers; Breast Neoplasms; CD24 Antigen; Cell Separation; Cyclohexanones; Female; Gene Expression Profiling; Genetic Vectors; Humans; Hyaluronan Receptors; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Proteins; Neoplastic Stem Cells; NF-kappa B; Oligonucleotide Array Sequence Analysis; Signal Transduction; Transduction, Genetic; Xenograft Model Antitumor Assays

2010
Potent cytotoxic effect of a novel nuclear factor-kappaB inhibitor dehydroxymethylepoxyquinomicin on human bladder cancer cells producing various cytokines.
    Urology, 2010, Volume: 75, Issue:4

    Topics: Animals; Benzamides; Cyclohexanones; Cytokines; Disease Models, Animal; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Nude; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2010
Inhibition of active HIV-1 replication by NF-kappaB inhibitor DHMEQ.
    Microbes and infection, 2010, Volume: 12, Issue:5

    Topics: Anti-HIV Agents; Benzamides; Cell Line; Cells, Cultured; Cyclohexanones; HIV-1; Humans; Immunologic Factors; Leukocytes, Mononuclear; NF-kappa B; Virus Replication

2010
Dehydroxymethylepoxyquinomicin inhibits expression and production of inflammatory mediators in interleukin-1beta-induced human chondrocytes.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, Volume: 25, Issue:4-5

    Topics: Benzamides; Cartilage, Articular; Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Chondrocytes; Cyclohexanones; Cyclooxygenase 2; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-8; Nitrates; Nitric Oxide Synthase Type II

2010
Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, prevents inflammatory injury induced by interferon-gamma and histamine in NCTC 2544 keratinocytes.
    Clinical and experimental pharmacology & physiology, 2010, Volume: 37, Issue:7

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Cell Line; Chemokine CCL2; Chemokine CCL5; Cyclohexanones; Histamine; Humans; Hydrocortisone; Inflammation; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-8; Keratinocytes; NF-kappa B

2010
Regulation of human dendritic cells by a novel specific nuclear factor-kappaB inhibitor, dehydroxymethylepoxyquinomicin.
    Human immunology, 2010, Volume: 71, Issue:8

    Topics: B7-1 Antigen; B7-2 Antigen; Benzamides; Blotting, Western; CD40 Antigens; Cell Survival; Cells, Cultured; Cyclohexanones; Cytokines; Dendritic Cells; DNA; Dose-Response Relationship, Drug; Flow Cytometry; HLA-DR Antigens; Humans; Interleukin-10; Lipopolysaccharides; Monocytes; NF-kappa B; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Th1 Cells; Time Factors

2010
Topical application of dehydroxymethylepoxyquinomicin improves allergic inflammation via NF-kappaB inhibition.
    The Journal of allergy and clinical immunology, 2010, Volume: 126, Issue:2

    Topics: Active Transport, Cell Nucleus; Administration, Topical; Animals; Benzamides; Cell Line; Cyclohexanones; Dermatitis, Atopic; Disease Models, Animal; Humans; Mice; NF-kappa B

2010
Donor pretreatment with DHMEQ improves islet transplantation.
    The Journal of surgical research, 2010, Volume: 163, Issue:1

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzamides; Caspase 3; Caspase 7; Cyclohexanones; Cytokines; Glucose; Glucose Tolerance Test; In Situ Nick-End Labeling; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Tissue Donors; Transplantation, Isogeneic; Transplants

2010
The side population, as a precursor of Hodgkin and Reed-Sternberg cells and a target for nuclear factor-κB inhibitors in Hodgkin's lymphoma.
    Cancer science, 2010, Volume: 101, Issue:11

    Topics: Antibiotics, Antineoplastic; Apoptosis; Benzamides; Cell Line, Tumor; Cell Survival; Cyclohexanones; Doxorubicin; Drug Resistance; Flow Cytometry; Giant Cells; Hodgkin Disease; Humans; Immunohistochemistry; Ki-1 Antigen; Leukocytes, Mononuclear; Microscopy, Fluorescence; Neoplastic Stem Cells; NF-kappa B; Reed-Sternberg Cells

2010
A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ.
    Bioorganic & medicinal chemistry letters, 2010, Oct-01, Volume: 20, Issue:19

    Topics: Animals; Benzamides; Cell Line, Tumor; Cyclohexanones; Epoxy Compounds; Hydroquinones; Mice; NF-kappa B; Nitric Oxide; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2010
Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.
    Investigative ophthalmology & visual science, 2011, Jan-21, Volume: 52, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Benzamides; Blindness; Burns, Chemical; Chemokine CCL2; Corneal Neovascularization; Cyclohexanones; Deuterium Oxide; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Eye Burns; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Microscopy, Fluorescence; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Sodium Hydroxide; Superoxide Dismutase; Superoxide Dismutase-1; Vascular Endothelial Growth Factor A

2011
Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway.
    Biology of reproduction, 2011, Volume: 84, Issue:2

    Topics: Amnion; Animals; Apoptosis; Benzamides; Cyclohexanones; Female; Gestational Age; Macrophages; Mice; Mice, Inbred ICR; NF-kappa B; Peptides, Cyclic; Pregnancy; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Tight Junctions; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factors

2011
Efficient cellular uptake of the novel NF-kappaB inhibitor (-)-DHMEQ and irreversible inhibition of NF-kappaB in neoplastic cells.
    Oncology research, 2010, Volume: 18, Issue:11-12

    Topics: Animals; Benzamides; Cell Survival; Cells, Cultured; Cyclohexanones; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II

2010
Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I-associated neurologic disease.
    Blood, 2011, Mar-24, Volume: 117, Issue:12

    Topics: Benzamides; Cell Proliferation; Cells, Cultured; Cyclohexanones; Drug Evaluation, Preclinical; HeLa Cells; Human T-lymphotropic virus 1; Humans; Immunologic Factors; Immunotherapy; Leukocytes, Mononuclear; Lymphocyte Activation; NF-kappa B; Paraparesis, Tropical Spastic; Signal Transduction; Viral Load

2011
Inhibition of nuclear factor-kappaB suppresses peritoneal dissemination of gastric cancer by blocking cancer cell adhesion.
    Cancer science, 2011, Volume: 102, Issue:5

    Topics: Animals; Antineoplastic Agents; Benzamides; Cell Adhesion; Cell Line, Tumor; Cell Separation; Cyclohexanones; Flow Cytometry; Humans; Male; Mice; Mice, Nude; Neoplasm Invasiveness; NF-kappa B; Peritoneal Neoplasms; Stomach Neoplasms; Xenograft Model Antitumor Assays

2011
Anti-tumor activity of dehydroxymethylepoxyquinomicin against human oral squamous cell carcinoma cell lines in vitro and in vivo.
    Oral oncology, 2011, Volume: 47, Issue:5

    Topics: Animals; Antineoplastic Agents; Benzamides; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cyclohexanones; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Inhibitor of Apoptosis Proteins; Mice; Mouth Neoplasms; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

2011
Chemoenzymatic synthesis of (2R,3R,4R)-dehydroxymethylepoxyquinomicin (DHMEQ), a new activator of antioxidant transcription factor Nrf2.
    Organic & biomolecular chemistry, 2011, Jun-21, Volume: 9, Issue:12

    Topics: Antineoplastic Agents; Antioxidants; Benzamides; Biocatalysis; Burkholderia cepacia; Cell Line, Tumor; Cyclohexanones; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Lipase; Luciferases; Neuroblastoma; NF-E2-Related Factor 2; NF-kappa B; Reactive Oxygen Species; Stereoisomerism

2011
Bioimaging analysis of nuclear factor-κB activity in Philadelphia chromosome-positive acute lymphoblastic leukemia cells reveals its synergistic upregulation by tumor necrosis factor-α-stimulated changes to the microenvironment.
    Cancer science, 2011, Volume: 102, Issue:11

    Topics: Animals; Antineoplastic Agents; Benzamides; Bone Marrow; Cell Line, Tumor; Cyclohexanones; Disease Progression; Gene Expression Regulation, Leukemic; Genes, Reporter; Humans; Imatinib Mesylate; Luminescent Measurements; Mice; Neoplasm Proteins; NF-kappa B; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Fusion Proteins; Spleen; Stromal Cells; Transgenes; Transplantation, Heterologous; Tumor Burden; Tumor Microenvironment; Tumor Necrosis Factor-alpha

2011
Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components.
    Bioorganic & medicinal chemistry letters, 2011, Nov-01, Volume: 21, Issue:21

    Topics: Benzamides; Biotin; Cyclohexanones; Humans; NF-kappa B; Structure-Activity Relationship

2011
Coffee induces breast cancer resistance protein expression in Caco-2 cells.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:10

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Breast Neoplasms; Caco-2 Cells; Cell Culture Techniques; Coffee; Cyclohexanones; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Gene Expression; Humans; Molecular Targeted Therapy; Neoplasm Proteins; NF-kappa B; Plant Extracts

2011
Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor-κB, on glioblastoma.
    Neuro-oncology, 2012, Volume: 14, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclohexanones; Glioblastoma; Humans; Male; Mice; Mice, Nude; NF-kappa B; Transcription Factor RelA; Xenograft Model Antitumor Assays

2012
Dehydroxymethylepoxyquinomicin (DHMEQ) can suppress tumour necrosis factor-α production in lipopolysaccharide-injected mice, resulting in rescuing mice from death in vivo.
    Clinical and experimental immunology, 2011, Volume: 166, Issue:2

    Topics: Animals; Apoptosis; Benzamides; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cyclohexanones; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Shock, Septic; Spleen; Tumor Necrosis Factor-alpha

2011
Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer.
    Oncogene, 2012, Sep-13, Volume: 31, Issue:37

    Topics: Benzamides; Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Disease-Free Survival; ErbB Receptors; Female; Humans; Interleukin-6; Neoplasms, Glandular and Epithelial; NF-kappa B; Ovarian Neoplasms; Plasminogen Activator Inhibitor 1; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Tumor Microenvironment; Tyrphostins

2012
A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice.
    Journal of Crohn's & colitis, 2012, Volume: 6, Issue:2

    Topics: Animals; Benzamides; CD4-Positive T-Lymphocytes; Chemokine CCL2; Colitis; Cyclohexanones; Cytokines; Dextran Sulfate; HT29 Cells; Humans; Interleukin-12 Subunit p40; Interleukin-17; Interleukin-1beta; Interleukin-6; Interleukin-8; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha

2012
The novel NF-κB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism.
    Cancer letters, 2012, Sep-01, Volume: 322, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Benzamides; Carcinoma, Hepatocellular; Celecoxib; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Cyclooxygenase 2 Inhibitors; Drug Synergism; Endoplasmic Reticulum Stress; fas Receptor; Humans; Liver Neoplasms; NF-kappa B; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Pyrazoles; Reactive Oxygen Species; Repressor Proteins; Sulfonamides

2012
Immunomodulatory effect of nuclear factor-κB inhibition by dehydroxymethylepoxyquinomicin in combination with donor-specific blood transfusion.
    Transplantation, 2012, Apr-27, Volume: 93, Issue:8

    Topics: Animals; Benzamides; Blood Transfusion; Combined Modality Therapy; Cyclohexanones; Graft Survival; H-2 Antigens; Heart Transplantation; Immune Tolerance; Immunologic Factors; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; NF-kappa B; T-Lymphocytes, Regulatory

2012
Inhibition of nuclear factor-κB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells.
    Anti-cancer drugs, 2012, Volume: 23, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cisplatin; Cyclohexanones; Doxorubicin; Drug Administration Schedule; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Methotrexate; Mitotic Index; NF-kappa B; Osteosarcoma; Protein Transport

2012
Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB.
    Organic & biomolecular chemistry, 2012, Apr-21, Volume: 10, Issue:15

    Topics: Alanine; Amino Acid Sequence; Arginine; Benzamides; Binding Sites; Cell Nucleus; Cyclohexanones; HeLa Cells; Humans; Karyopherins; Models, Molecular; Molecular Sequence Data; Mutation; Nuclear Localization Signals; Protein Stability; Protein Structure, Tertiary; Protein Transport; Recombinant Proteins; Transcription Factor RelB; Tyrosine

2012
Involvement of NF-κB-mediated expression of galectin-3-binding protein in TNF-α-induced breast cancer cell adhesion.
    Oncology reports, 2012, Volume: 27, Issue:6

    Topics: Antigens, Neoplasm; Benzamides; Biomarkers, Tumor; Breast Neoplasms; Carrier Proteins; Cell Adhesion; Cell Line, Tumor; Cyclohexanones; Female; Glycoproteins; Humans; NF-kappa B; RNA Interference; RNA, Small Interfering; Tumor Necrosis Factor-alpha

2012
Suppression of inflammatory cytokine secretion by an NF-ĸB inhibitor DHMEQ in nasal polyps fibroblasts.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 30, Issue:1

    Topics: Active Transport, Cell Nucleus; Androstadienes; Anti-Inflammatory Agents; Benzamides; Cell Survival; Cells, Cultured; Chemokine CCL5; Cyclohexanones; Cytokines; Fibroblasts; Fluticasone; Gene Expression; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Nasal Polyps; NF-kappa B; Rhinitis; Sinusitis; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2012
Enhancement of radiosensitivity by a unique novel NF-κB inhibitor, DHMEQ, in prostate cancer.
    British journal of cancer, 2012, Aug-07, Volume: 107, Issue:4

    Topics: Animals; Antineoplastic Agents; Benzamides; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Cyclohexanones; Humans; Male; Mice; Mice, Nude; NF-kappa B; Prostatic Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Xenograft Model Antitumor Assays

2012
Dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, inhibits allergic inflammation and airway remodelling in murine models of asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2012, Volume: 42, Issue:8

    Topics: Airway Remodeling; Animals; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cyclohexanones; Cytokines; Disease Models, Animal; Eosinophils; Epithelial Cells; Female; Humans; Inflammation; Inflammation Mediators; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; NF-kappa B; Respiratory Hypersensitivity

2012
A chemo-enzymatic expeditious route to racemic dihexanoyl (2R*,3R*,4R*)-dehydroxymethylepoxyquinomycin (DHMEQ), the precursor for lipase-catalyzed synthesis of the potent nuclear factor-κB inhibitor, (2S,3S,4S)-DHMEQ.
    Chemical & pharmaceutical bulletin, 2012, Volume: 60, Issue:9

    Topics: Benzamides; Benzoquinones; Burkholderia cepacia; Catalysis; Cyclohexanones; Hydroquinones; I-kappa B Proteins; Lipase; NF-KappaB Inhibitor alpha; Oxidation-Reduction; Stereoisomerism

2012
Combined effect of dehydroxymethylepoxyquinomicin and gemcitabine in a mouse model of liver metastasis of pancreatic cancer.
    Clinical & experimental metastasis, 2013, Volume: 30, Issue:4

    Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Blotting, Western; Cell Movement; Cell Proliferation; Cyclohexanones; Deoxycytidine; Disease Models, Animal; Fluorescent Antibody Technique; Gemcitabine; Humans; Immunoenzyme Techniques; Interleukin-8; Liver Neoplasms; Matrix Metalloproteinase 9; Mice; Mice, Nude; NF-kappa B; Pancreatic Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2013
Immunosuppressive effects of DTCM-G, a novel inhibitor of the mTOR downstream signaling pathway.
    Transplantation, 2013, Feb-27, Volume: 95, Issue:4

    Topics: Animals; Benzamides; Calcineurin; Calcineurin Inhibitors; Cell Cycle; Cell Proliferation; Cells, Cultured; Combined Modality Therapy; Cyclohexanones; Dose-Response Relationship, Drug; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B; Phosphorylation; Piperidones; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; T-Lymphocytes; Tacrolimus; Time Factors; TOR Serine-Threonine Kinases

2013
Enhanced NF-κB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes.
    Diabetes, 2013, Volume: 62, Issue:6

    Topics: Animals; Benzamides; Cells, Cultured; Cyclohexanones; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Endothelial Cells; Male; Mice; NF-kappa B; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Real-Time Polymerase Chain Reaction; Sp1 Transcription Factor

2013
Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway.
    Biochemical and biophysical research communications, 2013, Apr-05, Volume: 433, Issue:2

    Topics: Animals; Antioxidant Response Elements; Apoptosis; Benzamides; Cyclohexanones; Gene Knockdown Techniques; Insulin-Secreting Cells; Insulinoma; Mice; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Pancreatic Neoplasms; Signal Transduction; Tumor Cells, Cultured

2013
A novel nuclear factor κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates puromycin aminonucleoside-induced nephrosis in mice.
    American journal of nephrology, 2013, Volume: 37, Issue:4

    Topics: Adenosine Deaminase; Albuminuria; Animals; Benzamides; Blood Proteins; Cholesterol; Cyclohexanones; Glycerolphosphate Dehydrogenase; Interleukin-6; Intracellular Signaling Peptides and Proteins; Kidney; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Nephrosis; NF-kappa B; Proteinuria; Puromycin Aminonucleoside; Rats; Serum Albumin

2013
Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF-κB suppression via reactive oxygen species and unfolded protein response.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Jun-15, Volume: 190, Issue:12

    Topics: Animals; Benzamides; Blotting, Northern; Blotting, Western; Cyclohexanones; HEK293 Cells; Humans; Immunoprecipitation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Rats; Reactive Oxygen Species; Signal Transduction; Transfection; Unfolded Protein Response

2013
Efficacy of DHMEQ, a NF-κB inhibitor, in islet transplantation: II. Induction DHMEQ treatment ameliorates subsequent alloimmune responses and permits long-term islet allograft acceptance.
    Transplantation, 2013, Sep-15, Volume: 96, Issue:5

    Topics: Animals; Benzamides; Cyclohexanones; Cytokines; Dendritic Cells; Graft Survival; HMGB1 Protein; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; NF-kappa B; Postoperative Complications; Tacrolimus; Transplantation, Homologous

2013
Efficacy of DHMEQ, a NF-κB inhibitor, in islet transplantation: I. HMGB1 suppression by DHMEQ prevents early islet graft damage.
    Transplantation, 2013, Sep-15, Volume: 96, Issue:5

    Topics: Animals; Benzamides; Cyclohexanones; Diabetes Mellitus, Experimental; HMGB1 Protein; Islets of Langerhans Transplantation; Liposomes; Macrophage Activation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Postoperative Complications; Streptozocin

2013
Synergistic effect of 5-azacytidine and NF-κB inhibitor DHMEQ on apoptosis induction in myeloid leukemia cells.
    Oncology research, 2012, Volume: 20, Issue:12

    Topics: Apoptosis; Azacitidine; Benzamides; Cell Line, Tumor; Cyclohexanones; Drug Synergism; HL-60 Cells; Humans; K562 Cells; Leukemia, Myeloid; NF-kappa B; Tumor Cells, Cultured

2012
Inhibition of the NF-κB pathway as a candidate therapeutic strategy for cryopyrin-associated periodic syndrome.
    Modern rheumatology, 2014, Volume: 24, Issue:3

    Topics: Benzamides; Cryopyrin-Associated Periodic Syndromes; Cyclohexanones; Cytokines; Human Umbilical Vein Endothelial Cells; Humans; Leukocytes, Mononuclear; NF-kappa B; Signal Transduction

2014
Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells.
    Lung cancer (Amsterdam, Netherlands), 2014, Volume: 83, Issue:2

    Topics: Adenocarcinoma; Aged; Apoptosis; Benzamides; Cell Survival; Cells, Cultured; Cyclohexanones; Drug Synergism; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Lung Neoplasms; Male; Mechanistic Target of Rapamycin Complex 1; Middle Aged; Multiprotein Complexes; Neoplasm Staging; NF-kappa B; Oncogene Protein v-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Tetrazoles; TOR Serine-Threonine Kinases

2014
Synthesis and evaluation of a cyclopropane derivative of DHMEQ.
    Chemical & pharmaceutical bulletin, 2014, Volume: 62, Issue:3

    Topics: Animals; Benzamides; Cells, Cultured; Cyclohexanones; Cyclooxygenase 2; Cyclopropanes; Mice; NF-kappa B

2014
Nuclear factor kappa B inhibition improves conductance artery function in type 2 diabetic mice.
    Diabetes/metabolism research and reviews, 2015, Volume: 31, Issue:1

    Topics: Animals; Aorta, Thoracic; Arteries; Benzamides; Cyclohexanones; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endothelium, Vascular; Heart Conduction System; I-kappa B Proteins; Male; Mice; Mice, Knockout; NF-kappa B; Vasodilation

2015
The NF-κB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma.
    Cancer letters, 2014, Jul-10, Volume: 349, Issue:1

    Topics: Antineoplastic Agents; Benzamides; CD40 Antigens; Cell Line, Tumor; Chemokine CCL17; Chemokine CCL5; Cyclohexanones; Down-Regulation; Drug Synergism; Hodgkin Disease; Humans; Interferon Regulatory Factors; Interleukin-6; Ki-1 Antigen; NF-kappa B; Reactive Oxygen Species; Tumor Microenvironment

2014
DSE-FRET: A new anticancer drug screening assay for DNA binding proteins.
    Cancer science, 2014, Volume: 105, Issue:7

    Topics: Benzamides; Binding Sites; Cyclohexanones; DNA Probes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Evans Blue; Fluorescence Resonance Energy Transfer; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; NF-kappa B; Recombinant Proteins

2014
Combined inhibition of NF-κB and Bcl-2 triggers synergistic reduction of viability and induces apoptosis in melanoma cells.
    Oncology research, 2013, Volume: 21, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Cell Line, Tumor; Cell Survival; Cyclohexanones; Drug Synergism; Humans; Indoles; Melanoma; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction; Tumor Cells, Cultured

2013
Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor.
    British journal of cancer, 2014, Jun-10, Volume: 110, Issue:12

    Topics: Adoptive Transfer; Animals; Arginase; Benzamides; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Culture Media, Conditioned; Cyclohexanones; Dendritic Cells; Female; Humans; Immune Tolerance; Interleukin-6; Interleukin-8; Macrophages; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Signal Transduction; Transcription Factor RelA; Transplantation, Heterologous

2014
Strategic targeting of the PI3K-NFκB axis in cisplatin-resistant NSCLC.
    Cancer biology & therapy, 2014, Volume: 15, Issue:10

    Topics: Antineoplastic Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Cyclohexanones; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Transcriptome

2014
Aberrant expression of NF-κB in liver fluke associated cholangiocarcinoma: implications for targeted therapy.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Animals; Apoptosis; Benzamides; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Blotting, Western; Cholangiocarcinoma; Cyclohexanones; Dose-Response Relationship, Drug; Female; Host-Parasite Interactions; Humans; Immunohistochemistry; Janus Kinase 3; Liver; Male; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Middle Aged; NF-kappa B; Opisthorchiasis; Opisthorchis; Tumor Burden; Xenograft Model Antitumor Assays

2014
Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-κB inhibitor, (-)-DHMEQ.
    Oncology research, 2013, Volume: 21, Issue:6

    Topics: Animals; Anoikis; Apoptosis Regulatory Proteins; Benzamides; Cell Line, Tumor; Cyclohexanones; Disease Models, Animal; Gene Expression; Genes, Reporter; Humans; Mice; Molecular Imaging; NF-kappa B; Pancreatic Neoplasms; Peritoneal Neoplasms; Protein Binding; Transcription Factor RelA; Tumor Burden; Xenograft Model Antitumor Assays

2013
Nuclear factor-κB activation inhibitor attenuates ischemia reperfusion injury and inhibits Hmgb1 expression.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2014, Volume: 63, Issue:11

    Topics: Animals; Apoptosis; Benzamides; Cyclohexanones; Glycyrrhizic Acid; Heart Transplantation; HMGB1 Protein; Male; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Neutrophil Infiltration; NF-kappa B; Peroxidase; Reperfusion Injury; Troponin T

2014
Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, reduces chemokines and adhesion molecule expression induced by IL-1β in human corneal fibroblasts.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2015, Volume: 253, Issue:4

    Topics: Benzamides; Cell Proliferation; Cell Survival; Cells, Cultured; Chemokine CCL2; Corneal Keratocytes; Cyclohexanones; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-8; NF-kappa B; Transcription Factor RelA

2015
Dehydroxymethylepoxyquinomicin selectively ablates T-CAEBV cells.
    Frontiers in bioscience (Landmark edition), 2015, 01-01, Volume: 20, Issue:3

    Topics: Apoptosis; Base Sequence; Benzamides; Cells, Cultured; Chronic Disease; Cyclohexanones; DNA Primers; Epstein-Barr Virus Infections; Flow Cytometry; Gene Expression; Humans; NF-kappa B; Oxidative Stress; Real-Time Polymerase Chain Reaction

2015
Inhibition of canonical NF-κB nuclear localization by (-)-DHMEQ via impairment of DNA binding.
    Oncology research, 2015, Volume: 22, Issue:2

    Topics: Benzamides; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cyclohexanones; DNA; Enzyme Activation; Gene Expression; HeLa Cells; Humans; Leukemia-Lymphoma, Adult T-Cell; Models, Biological; Mutation; NF-kappa B; Protein Binding; Protein Transport; Transcription Factor RelA

2015
Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells.
    International archives of allergy and immunology, 2015, Volume: 166, Issue:2

    Topics: Animals; Benzamides; Cell Line, Tumor; Cell Movement; Collagen; Cyclohexanones; Dipeptides; Drug Combinations; Electrophoretic Mobility Shift Assay; Interleukin-6; Laminin; Mast Cells; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mice; NF-kappa B; Proteoglycans; Rats; Real-Time Polymerase Chain Reaction; RNA; Tumor Necrosis Factor-alpha

2015
A nuclear factor-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates GVHD in allogeneic bone marrow transplantation.
    Immunobiology, 2015, Volume: 220, Issue:9

    Topics: Animals; Antibodies; Benzamides; Bone Marrow Transplantation; Cell Proliferation; Cyclohexanones; Cytokines; Graft vs Host Disease; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B; Receptors, Cell Surface; Spleen; Survival Rate; T-Lymphocytes, Regulatory; Transplantation, Homologous

2015
Inhibition of NF-κB Activity Enhances Sensitivity to Anticancer Drugs in Cholangiocarcinoma Cells.
    Oncology research, 2016, 01-21, Volume: 23, Issue:1-2

    Topics: Antineoplastic Agents; Apoptosis; ATP-Binding Cassette Transporters; Benzamides; Bile Duct Neoplasms; Cell Line, Tumor; Cell Survival; Cholangiocarcinoma; Cisplatin; Cyclohexanones; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Gene Expression; Humans; NF-kappa B

2016
Treatment with novel AP-1 and NF-κB inhibitors restores the colonic endocrine cells to normal levels in rats with DSS-induced colitis.
    International journal of molecular medicine, 2016, Volume: 37, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Benzamides; Carboxymethylcellulose Sodium; Colitis; Colon; Cyclohexanones; Dextran Sulfate; Disease Models, Animal; Endocrine Cells; Male; NF-kappa B; Piperidones; Rats; Rats, Wistar; Transcription Factor AP-1

2016
Anti-inflammatory effects of novel AP-1 and NF-κB inhibitors in dextran-sulfate-sodium-induced colitis in rats.
    International journal of molecular medicine, 2016, Volume: 37, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Carboxymethylcellulose Sodium; Colitis; Colon; Cyclohexanones; Dextran Sulfate; Gene Expression Regulation; Lymphocytes; Macrophages; Male; Mast Cells; Monocytes; NF-kappa B; Piperidones; Rats; Rats, Wistar; Signal Transduction; Transcription Factor AP-1; Treatment Outcome

2016
Effects of AP‑1 and NF‑κB inhibitors on colonic endocrine cells in rats with TNBS‑induced colitis.
    Molecular medicine reports, 2016, Volume: 14, Issue:2

    Topics: Animals; Benzamides; Biomarkers; Body Weight; Chromogranin A; Colitis; Cyclohexanones; Disease Models, Animal; Endocrine Cells; Gene Expression; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; NF-kappa B; Piperidones; Rats; Serotonin; Transcription Factor AP-1; Trinitrobenzenesulfonic Acid

2016
Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model.
    Oncotarget, 2016, Oct-18, Volume: 7, Issue:42

    Topics: Adenomatous Polyposis Coli; Animals; Benzamides; Cell Transformation, Neoplastic; Cyclohexanones; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Membrane Glycoproteins; Mice, Knockout; Mice, Transgenic; Neoplasms; NF-kappa B; Proteinase Inhibitory Proteins, Secretory; Signal Transduction

2016
Inhibition of MMP-2-mediated cellular invasion by NF-κB inhibitor DHMEQ in 3D culture of breast carcinoma MDA-MB-231 cells: A model for early phase of metastasis.
    Biochemical and biophysical research communications, 2017, 03-25, Volume: 485, Issue:1

    Topics: Antineoplastic Agents; Benzamides; Breast; Breast Neoplasms; Cell Line, Tumor; Cyclohexanones; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic

2017
NF-κB Is a Potential Molecular Drug Target in Triple-Negative Breast Cancers.
    Omics : a journal of integrative biology, 2017, Volume: 21, Issue:4

    Topics: Benzamides; Cell Line, Tumor; Curcumin; Cyclohexanones; Female; Humans; NF-kappa B; Precision Medicine; Signal Transduction; Triple Negative Breast Neoplasms

2017
External application of NF-κB inhibitor DHMEQ suppresses development of atopic dermatitis-like lesions induced with DNCB/OX in BALB/c mice.
    Immunopharmacology and immunotoxicology, 2017, Volume: 39, Issue:3

    Topics: Animals; Benzamides; Cyclohexanones; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Epidermis; Mice; Mice, Inbred BALB C; NF-kappa B; Ointments; Oxazolone

2017
Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia.
    Haematologica, 2018, Volume: 103, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Benzamides; Biomarkers; Cell Line, Tumor; Cell Survival; Coculture Techniques; Cyclohexanones; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mesenchymal Stem Cells; NF-kappa B; RNA, Small Interfering; Signal Transduction; Tumor Microenvironment

2018
Antineoplastic Effects of NF-κB Inhibition by DHMEQ (Dehydroxymethylepoxyquinomicin) Alone and in Co-treatment with Radio-and Chemotherapy in Medulloblastoma Cell Lines.
    Anti-cancer agents in medicinal chemistry, 2018, Volume: 18, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Benzamides; Cell Movement; Cell Proliferation; Cyclohexanones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Medulloblastoma; Molecular Structure; NF-kappa B; Structure-Activity Relationship; Tumor Cells, Cultured

2018
NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.
    Molecular medicine reports, 2018, Volume: 18, Issue:6

    Topics: Animals; Benzamides; Biomarkers; Caspase 1; Caspase Inhibitors; Cell Line; Cyclohexanones; Disease Models, Animal; Humans; Inflammation; Interleukin-1beta; Macrophages; Models, Molecular; Nanoparticles; NF-kappa B; Particulate Matter; Potassium; Titanium

2018
Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum.
    International immunopharmacology, 2019, Volume: 71

    Topics: Animals; Benzamides; Cyclohexanones; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Models, Animal; Epidermis; Female; Humans; Immunoglobulin E; Immunosuppressive Agents; Inflammation Mediators; Mast Cells; Mice; Mice, Inbred BALB C; Ointments; Oxazolone; Tacrolimus

2019
Anti-Inflammatory Effect of Dehydroxymethylepoxyquinomicin, a Nuclear factor-κB Inhibitor, on Endotoxin-Induced Uveitis in Rats In vivo and In vitro.
    Ocular immunology and inflammation, 2020, Volume: 28, Issue:2

    Topics: Animals; Aqueous Humor; Benzamides; Cells, Cultured; Cyclohexanones; Disease Models, Animal; Immunohistochemistry; Male; NF-kappa B; Rats, Inbred Lew; Treatment Outcome; Uveitis

2020
Role of nuclear factor-kappa B in feline injection site sarcoma.
    BMC veterinary research, 2019, Oct-25, Volume: 15, Issue:1

    Topics: Animals; Apoptosis; Benzamides; Cat Diseases; Cats; Cell Line, Tumor; Cyclohexanones; Female; Injection Site Reaction; Male; Sarcoma; Signal Transduction; Transcription Factor RelA

2019
Anti‑inflammatory effects of the NF‑κB inhibitor dehydroxymethylepoxyquinomicin on ARPE‑19 cells.
    Molecular medicine reports, 2020, Volume: 22, Issue:1

    Topics: Anti-Inflammatory Agents; Apoptosis; Benzamides; Cell Line; Cell Survival; Chemokines; Cyclohexanones; Humans; NF-kappa B; Retinal Pigment Epithelium; Tumor Necrosis Factor-alpha

2020
Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling.
    International journal of oncology, 2020, Volume: 57, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Benzamides; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclohexanones; Female; Gastrectomy; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; MicroRNAs; Middle Aged; Neoplasm Invasiveness; NF-kappa B; Prognosis; Repressor Proteins; Signal Transduction; Stomach; Stomach Neoplasms; Up-Regulation

2020
Dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model.
    BMC pharmacology & toxicology, 2020, 08-12, Volume: 21, Issue:1

    Topics: Animals; Benzamides; Cyclohexanones; Cyclosporine; DNA; Immunosuppressive Agents; Kidney; Kidney Diseases; Male; NF-kappa B; Protective Agents; Rats, Sprague-Dawley

2020
Intravenous Administration of Dehydroxymethylepoxyquinomicin With Polymer Enhances the Inhibition of Pancreatic Carcinoma Growth in Mice.
    Anticancer research, 2021, Volume: 41, Issue:12

    Topics: Administration, Intravenous; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Cell Cycle; Cell Line, Tumor; Cyclohexanones; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Humans; Mice; Molecular Structure; Polymers; Protein Kinase Inhibitors; Xenograft Model Antitumor Assays

2021