tifluadom has been researched along with naloxone in 28 studies
| Studies (tifluadom) | Trials (tifluadom) | Recent Studies (post-2010) (tifluadom) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 78 | 0 | 0 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | tifluadom (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (85.71) | 18.7374 |
| 1990's | 4 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, C; Li, JG; Liu-Chen, LY; Luo, LY; Zhu, J | 1 |
| Dong, XW; Headley, PM; Parsons, CG | 1 |
| Caliezi, A; Drack, E; Halter, F; Scheurer, U; Varga, L; Wenger, F | 1 |
| Bock, MG; Chang, RS; Chen, TB; DiPardo, RM; Evans, BE; Freidinger, RM; Lotti, VJ; Rittle, KE; Veber, DF; Whitter, WL | 1 |
| Headley, PM; Parsons, CG; West, DC | 2 |
| Dykstra, LA; Picker, MJ | 1 |
| Cunningham, FJ; Stansfield, SC | 1 |
| Frey, HH | 1 |
| Cowan, A; Gmerek, DE | 1 |
| Cowan, A; Murray, C | 1 |
| Bueno, L; Fioramonti, J; Gué, M; Junien, JL | 1 |
| Hayes, A; Kelly, A | 1 |
| Grace, M; Kneip, J; Levine, AS; Morley, JE; Shearman, GT; Zeugner, H | 1 |
| Hayes, AG; Stewart, BR | 1 |
| Barber, DJ; Cooper, SJ; Jackson, A; Moores, WR | 1 |
| Boeck, G; Ciaramelli, F; Freye, E; Schaal, M | 1 |
| Huidobro-Toro, JP; López, LF; Pérez, A; Ureta, H | 1 |
| Freye, E; Schaal, M; Windelschmidt, R | 1 |
| Bueno, L; Fioramonti, J; Gue, M; Honde, C; Junien, JL; Pascaud, X | 1 |
| Blackburn, TP; Borkowski, KR; Friend, J; Rance, MJ | 1 |
| Dykstra, LA; Genovese, RF | 1 |
| Leander, JD | 2 |
| Jackson, HC; Sewell, RD | 1 |
| Benson, W; Büscher, HH; Finner, E; Hill, RC; Maurer, R; Milkowski, W; Petcher, TJ; Römer, D; Thies, PW; Zeugner, H | 1 |
| Grace, M; Kneip, J; Levine, AS; Morley, JE; Zeugner, H | 1 |
| Code, RA; Tang, AH | 1 |
28 other study(ies) available for tifluadom and naloxone
| Article | Year |
|---|---|
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylate Cyclase Toxin; Animals; Binding Sites; Cell Membrane; CHO Cells; Cholera Toxin; Cloning, Molecular; Cricetinae; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; Magnesium; Pertussis Toxin; Pyrrolidines; Receptors, Opioid, kappa; Recombinant Proteins; Sodium; Sulfur Radioisotopes; Virulence Factors, Bordetella | 1997 |
Effects of intravenous mu and kappa opioid receptor agonists on sensory responses of convergent neurones in the dorsal horn of spinalized rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Fentanyl; Hot Temperature; Male; Morphine; Naloxone; Neurons, Afferent; Nociceptors; Physical Stimulation; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1991 |
Different motor actions of dynorphins and nonpeptide kappa opioid receptor agonists in the isolated rat colon.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Antihypertensive Agents; Benzeneacetamides; Benzodiazepines; Benzomorphans; Colon; Diuretics; Dynorphins; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pressure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom.
Topics: Animals; Benzodiazepines; Brain; Cerebral Cortex; Chemical Phenomena; Chemistry; Cholecystokinin; Dihydromorphine; Guinea Pigs; Molecular Structure; Naloxone; Pancreas; Rats; Receptors, Cholecystokinin; Receptors, Opioid; Receptors, Opioid, kappa; Sincalide | 1990 |
Spinal antinociceptive actions and naloxone reversibility of intravenous mu- and kappa-opioids in spinalized rats: potency mismatch with values reported for spinal administration.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Decerebrate State; Electrophysiology; Hot Temperature; Injections; Naloxone; Narcotics; Neurons; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Spinal Cord | 1989 |
Discriminative stimulus effects of mu and kappa opioids in the pigeon: analysis of the effects of full and partial mu and kappa agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Columbidae; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Fentanyl; Morphinans; Naloxone; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Involvement of opiate receptor subtypes in the modulation of LHRH secretion by the cockerel (Gallus domesticus) mediobasal hypothalamus in vitro.
Topics: Animals; Benzodiazepines; Chickens; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Naloxone; Oligopeptides; Receptors, Opioid | 1987 |
Similar actions of kappa and mu agonists on spinal nociceptive reflexes in rats and their reversibility by naloxone.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Motor Neurons; Naloxone; Nociceptors; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1986 |
Effect of mu- and kappa-opioid agonists on the electroconvulsive seizure threshold in mice and antagonism by naloxone and MR 2266.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Benzodiazepines; Benzomorphans; Electroshock; Fentanyl; Male; Mice; Morphinans; Morphine; Nalbuphine; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures | 1988 |
Role of opioid receptors in bombesin-induced grooming.
Topics: Animals; Benzodiazepines; Bombesin; Cyclazocine; Drug Tolerance; Ethylketocyclazocine; Grooming; Molecular Conformation; Naloxone; Narcotics; Receptors, Opioid | 1988 |
Neuroadaptation of rats to kappa agonists U-50,488 and tifluadom.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adaptation, Physiological; Animals; Behavior, Animal; Benzodiazepines; Buprenorphine; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Stereotyped Behavior | 1988 |
Orally administered kappa but not mu opiate agonists enhance gastric emptying of a solid canned food meal in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animal Feed; Animals; Benzodiazepines; Benzomorphans; Diuretics; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gastric Emptying; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1988 |
Profile of activity of kappa receptor agonists in the rabbit vas deferens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1985 |
The kappa opioid receptor and food intake.
Topics: Animals; Benzodiazepines; Benzomorphans; Butorphanol; Cyclazocine; Diprenorphine; Eating; Ethylketocyclazocine; Haloperidol; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Time Factors | 1985 |
Effect of mu and kappa opioid receptor agonists on rat plasma corticosterone levels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Corticosterone; Dose-Response Relationship, Drug; Fentanyl; Male; Morphine; Naloxone; Naltrexone; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Effects of tifluadom on food consumption compared with chlordiazepoxide and kappa agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Chlordiazepoxide; Convulsants; Cyclazocine; Drug Interactions; Eating; Ethylketocyclazocine; Flumazenil; Male; Naloxone; Pyrazoles; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
The benzodiazepine (+)-tifluadom (KC-6128), but not its optical isomer (KC-5911) induces opioid kappa receptor-related EEG power spectra and evoked potential changes.
Topics: Animals; Benzodiazepines; Benzomorphans; Dogs; Electroencephalography; Evoked Potentials; Flumazenil; Naloxone; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1986 |
Kappa-opiate-induced diuresis and changes in blood pressure: demonstration of receptor stereoselectivity using (+)- and (-)-tifluadom.
Topics: Anesthesia; Animals; Benzodiazepines; Blood Pressure; Diuresis; Electrolytes; Female; Hemodynamics; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism | 1987 |
[Tifluadom, a benzodiazepine with opioid-like activity: study of its central mechanism of action in conscious dogs].
Topics: Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Brain; Dogs; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials, Somatosensory; Flumazenil; Naloxone | 1986 |
Opposite effects of kappa-opioid agonists on gastric emptying of liquids and solids in dogs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Oral; Animal Feed; Animals; Benzodiazepines; Benzomorphans; Dogs; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gastric Emptying; Injections, Intravenous; Morphinans; Morphine; Naloxone; Pyrrolidines | 1988 |
On the mechanisms of kappa-opioid-induced diuresis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Medulla; Animals; Benzodiazepines; Catecholamines; Corticosterone; Cyclazocine; Diuresis; Ethylketocyclazocine; Male; Naloxone; Narcotics; Pyrrolidines; Rats; Sympatholytics | 1986 |
Tifluadom's effects under electric shock titration and tail-immersion procedures in squirrel monkeys.
Topics: Analgesia; Animals; Benzodiazepines; Dose-Response Relationship, Drug; Electroshock; Hot Temperature; Male; Naloxone; Saimiri; Tail | 1986 |
Kappa opioid agonists and antagonists: effects on drinking and urinary output.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Benzomorphans; Butorphanol; Clonidine; Cyclazocine; Drinking; Ethylketocyclazocine; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Urination; Vasopressins | 1984 |
Kappa-opioid diuretic effects of tifluadom, a benzodiazepine opioid agonist.
Topics: Animals; Benzodiazepines; Diuresis; Morphine; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors | 1984 |
The role of opioid receptor sub-types in tifluadom-induced feeding.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Benzomorphans; Convulsants; Eating; Enkephalin, Leucine; Flumazenil; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Stereoisomerism | 1984 |
An opioid benzodiazepine.
Topics: Animals; Benzodiazepines; Binding, Competitive; Guinea Pigs; Mice; Naloxone; Nociceptors; Pain; Rabbits; Receptors, Opioid; Structure-Activity Relationship | 1982 |
The effect of the opioid-benzodiazepine, tifluadom, on ingestive behaviors.
Topics: Animals; Benzodiazepines; Butorphanol; Cyclazocine; Drinking Behavior; Ethylketocyclazocine; Feeding Behavior; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
Discriminative stimulus properties of nalorphine in the rhesus monkeys.
Topics: Animals; Benzodiazepines; Benzomorphans; Conditioning, Operant; Cyclazocine; Discrimination Learning; Dose-Response Relationship, Drug; Ethylketocyclazocine; Macaca mulatta; Male; Nalorphine; Naloxone; Phenazocine; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |