ticlopidine has been researched along with clopidogrel in 7959 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (0.06) | 18.7374 |
| 1990's | 170 (2.14) | 18.2507 |
| 2000's | 2970 (37.32) | 29.6817 |
| 2010's | 4661 (58.56) | 24.3611 |
| 2020's | 153 (1.92) | 2.80 |
| Authors | Studies |
|---|---|
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Ballard, TE; Henderson, JL; Kalgutkar, AS; Obach, RS; Orr, ST; Ripp, SL; Scott, DO; Sun, H | 1 |
| Brown, ED; Farha, MA; Gale, RT; Koteva, K; Sewell, EW; Wright, GD | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bernat, A; Herbert, JM; Maffrand, JP | 2 |
| Bailliart, O; Bonneau, M; Bonnin, P; Caen, JP; Drouet, LO; Maffrand, JP; Mazoyer, E; Pignaud, G; Samama, CM; Viars, P | 1 |
| Combalbert, J; Defreyn, G; Delebassee, D; Dol, F; Herbert, JM; Maffrand, JP; Pflieger, AM; Savi, P | 1 |
| Cazenave, JP; Gachet, C; Jakobs, KH; Maffrand, JP; Ohlmann, P; Savi, P | 1 |
| Colman, RF; Colman, RW; Freedman, MD; Grana, G; Hu, CJ; Mills, DC; Minniti, C; Puri, R | 1 |
| Maruyama, S; Uchiyama, S; Yamazaki, M | 1 |
| Anderson, HV; Benedict, CR; Buja, LM; Campbell, WB; Cui, K; Maffrand, JP; McNatt, J; Ober, JC; Rosolowsky, M; Yao, SK | 1 |
| Cazenave, JP; Freund, M; Mantz, F | 1 |
| Cazenave, JP; Defreyn, G; Driot, F; Gachet, C; Maffrand, JP; Savi, P | 1 |
| Bouloux, C; Cazenave, JP; Gachet, C; Lanza, F; Maffrand, JP; Ohlmann, P; Stierlé, A | 1 |
| Chap, H; Defreyn, G; Delebassée, D; Douste-Blazy, L; Féliste, R; Maffrand, JP; Simon, MF; Vallée, E | 1 |
| Bernat, A; Cazenave, JP; Defreyn, G; Delebassée, D; Gordon, JL; Maffrand, JP | 1 |
| Bernat, A; Gordon, JL; Maffrand, JP; Vallee, E | 1 |
| Chap, H; Defreyn, G; Douste-Blazy, L; Feliste, R; Maffrand, JP; Simon, MF | 1 |
| Damas, J; Grek, V; Remacle-Volon, G | 1 |
| Cazenave, JP; Herbert, JM; Klein-Soyer, C; Maffrand, JP | 1 |
| Ishihara, H; Kawai, H; Nakashima, M; Umemura, K | 1 |
| Verstraete, M; Zoldhelyi, P | 1 |
| Roald, HE; Sakariassen, KS | 1 |
| Hirata, Y; Nakashima, M; Uematsu, T; Umemura, K | 1 |
| Hanaoka, T | 1 |
| Berger, Y; Combalbert, J; Gaich, C; Herbert, JM; Maffrand, JP; Rouchon, MC; Savi, P | 1 |
| Herbert, JM; Laplace, MC; Savi, P | 1 |
| Anderson, HV; Buja, LM; Ferguson, JJ; Maffrand, JP; Ober, JC; Willerson, JT; Yao, SK | 2 |
| Bernat, A; Herbert, JM | 1 |
| Barstad, RM; Dickinson, JP; Kieffer, G; Kierulf, P; Roald, HE; Sakariassen, KS; Skjørten, F | 1 |
| Bernat, A; Defreyn, G; Herbert, JM; Maffrand, JP; Mares, AM | 1 |
| Aït-Chek, L; Bernat, A; Dumas, A; Herbert, JM; Savi, P | 1 |
| Herbert, JM; Laplace, MC; Maffrand, JP; Savi, P | 1 |
| Anderson, HV; Buja, LM; Cui, K; Maffrand, JP; McNatt, J; Willerson, JT; Yao, SK | 1 |
| Beretz, A; Cazenave, JP; Freund, M; Gachet, C; Mantz, F; Meyer, L; Mulvihill, J; Nicolini, P | 1 |
| Defreyn, G; Herbert, JM; Maffrand, JP; Tissinier, A | 1 |
| Bernat, A; Dol, F; Herbert, JM; Rinaldi, M; Sainte-Marie, M | 1 |
| Cassel, D; Cattaneo, M; Cazenave, JP; Chevalier, J; Gachet, C; Hechler, B; Lecchi, A; Mannucci, PM; Ohlmann, P | 1 |
| Ishihara, H; Nakashima, M; Umemura, K | 1 |
| Fukushi, H; Imura, Y; Kawamura, M; Kita, S; Moriya, N; Nishikawa, K; Sugihara, H; Terashita, Z | 1 |
| Bogousslavsky, J; Dewarrat, A | 1 |
| Adams, HP; Bendixen, BH | 1 |
| Boneu, B; Destelle, G | 1 |
| Bihour, C; Heilmann, E; Herbert, JM; Humbert, M; Kunicki, TJ; Nurden, AT; Nurden, P; Pasquet, JM; Savi, P; Winckler, J | 1 |
| Nurden, AT | 1 |
| Violi, F | 1 |
| Bahadori, B; Toplak, H; Wascher, TC | 1 |
| Green, D | 1 |
| Davie, AP; Love, MP | 1 |
| Barer, D | 1 |
| Born, GV; Collins, R | 1 |
| Artçanuthurry, V; Bornia, J; Grelac, F; Herbert, JM; Levy-Toledano, S; Maclouf, J; Savi, P | 1 |
| Keil, Tu | 1 |
| Fareed, J; Yang, LH | 1 |
| Hankey, GJ | 9 |
| Bernat, A; Herbert, JM; Hoffmann, P; Savi, P | 1 |
| Bornia, J; Delfaud, M; Herbert, JM; Salel, V; Savi, P | 1 |
| Coukell, AJ; Markham, A | 1 |
| Sternon, J | 2 |
| Hacke, W; Orberk, E; Schellinger, PD | 1 |
| Bergerat, JP; Cazenave, JP; Céraline, J; de la Salle, C; Klein-Soyer, C; Orvain, C | 1 |
| Schrör, K; Weber, AA | 1 |
| Beauverger, P; Delfaud, M; Herbert, JM; Kaghad, M; Labouret, C; Salel, V; Savi, P | 1 |
| Choussat, R; Montalescot, G | 1 |
| Forbes, CD | 2 |
| Roden, DM | 3 |
| Algra, A; Koudstaal, PJ; van Gijn, J | 1 |
| Ferguson, JJ; Gonzalez, ER; Kannel, WB; Olin, JW; Raps, EC | 1 |
| Diener, HC | 10 |
| Schneider, D | 1 |
| Boysen, G | 4 |
| Gorelick, PB; Hanley, DF | 1 |
| Cannon, CP; Loscalzo, J; Sharis, PJ | 1 |
| Bernat, A; Dol, F; Falotico, R; Herbert, JM; Lalé, A; Savi, P | 1 |
| Pepine, CJ | 1 |
| Habis, M; Morice, MC | 1 |
| Ellis, CJ; French, JK; White, HD | 1 |
| Dippel, DW | 1 |
| Gonzalez, ER | 1 |
| Gonzalez, ER; Kannewurf, BS | 1 |
| Tisdale, JE | 1 |
| Harbison, JW | 1 |
| Hilleman, DE | 1 |
| Clark, W; Kendall, MJ; Misson, J | 1 |
| Fareed, J; Hoppensteadt, D; Yang, LH | 1 |
| Topol, EJ | 2 |
| Eigler, NL; Forrester, JS; Frimerman, A; Herbert, JM; Kaul, S; Litvack, F; Makkar, RR; Nakamura, M; Shah, PK | 1 |
| Clagett, GP; Jackson, MR | 1 |
| Chronos, NR; Hanson, SR; Harker, LA; Herbert, JM; Kelly, AB; Marzec, UM; Sundell, IB | 1 |
| Cazenave, JP; Eckly, A; Gachet, C; Hechler, B; Ohlmann, P | 1 |
| Castillo, J | 1 |
| Bressolle, F; Lagorce, P; Necciari, J; Ortiz, J; Perez, Y | 1 |
| Schrör, K | 5 |
| Dormandy, JA | 1 |
| Creager, MA | 1 |
| Calverley, DC; Roth, GJ | 1 |
| Dyken, ML | 1 |
| Thizon-de-Gaulle, I | 1 |
| Reimann, S; Schrör, K; Weber, AA | 1 |
| Dol-Gleizes, F; Herbert, JM; Marés, AM; Savi, P | 1 |
| Collins, M; Colombo, A; Iyer, S; Kreps, E; Maida, R; Moses, JW; Moussa, I; Oetgen, M; Roubin, G; Wang, X | 1 |
| Arnout, J; Cariou, R; De Schepper, PJ; Depré, M; van Hecken, A; Vanbilloen, H; Vanhove, P; Verbruggen, A; Wynants, K | 1 |
| Steinhubl, SR; Topol, EJ | 2 |
| Cohen, M; Montalescot, G | 1 |
| Marks, KR; McCullough, PA | 1 |
| Kaluza, G; Kleiman, NS; Mazur, W | 1 |
| Fintel, D; Gheorghiade, M; Sauri, D; Tung, C | 1 |
| Burkhard-Meier, C; Deutsch, HJ; Erdmann, E | 1 |
| D'Sa, S; Machin, SJ | 1 |
| Bernat, A; Dol, F; Gaich, C; Hérault, JP; Herbert, JM | 1 |
| Priollet, P | 1 |
| de Carvalho, HC | 1 |
| Feret, B | 1 |
| Cummings, CC; Gurbel, PA; O'Connor, CM; Serebruany, VL | 1 |
| Born, GV; D'Agostino, RB; Gorelick, PB; Hanley, DF; Moye, L; Pepine, CJ | 1 |
| Algra, A; van Gijn, J | 2 |
| Gent, M | 1 |
| Cariou, R; Kieffer, G; Thebault, JJ | 1 |
| Cariou, R; Kieffer, G; Lowe, GD; Nimmo, WS; Thebault, JJ | 1 |
| Bachmann, F; Cariou, R; Geudelin, B; Hauert, J; Savcic, M; Wyld, PJ | 1 |
| Caplain, H; Cariou, R | 1 |
| Caplain, H; Donat, F; Gaud, C; Necciari, J | 1 |
| Broekhuysen, J; Deroubaix, X; Lins, R; Necciari, J | 1 |
| Dickinson, JP; Houle, JM; Kieffer, G; Kindermans, M; Necciari, J; Pierce, CH; Serre-Lacroix, E | 1 |
| Denninger, MH; Necciari, J; Serre-Lacroix, E; Sissmann, J | 1 |
| Dickinson, JP; McEwen, J; Moreland, TE; Necciari, J; Perles, P; Pritchard, G; Strauch, G | 1 |
| Crijns, HJ; Dickinson, JP; Jonkman, JH; Necciari, J; Peeters, PA; Tamminga, WJ | 1 |
| Dickinson, JP; Forbes, CD; Kieffer, G; Lowe, GD; MacLaren, M; Shaw, BG | 1 |
| Caplain, H; Cariou, R; D'Honneur, G | 1 |
| Caplain, H; Necciari, J; Thebault, JJ | 1 |
| Bassand, JP; Cariou, R; Grollier, G; Heyndrickx, GR; Kragten, J; Wolf, JE | 1 |
| Easton, JD | 3 |
| Ferguson, JJ | 3 |
| Brich, J; Eigenthaler, M; Geiger, J; Herbert, JM; Hönig-Liedl, P; Schanzenbächer, P; Walter, U | 1 |
| Herbert, JM; Savi, P | 3 |
| Jackson, A; Luisi, AF | 1 |
| Chesebro, JH; Comerota, A; Hartmann, JR; Massin, EK; Raps, E; Wolf, PA; Zusman, RM | 1 |
| Carson, JJ; Zeolla, MM | 1 |
| Willerson, JT; Zoldhelyi, P | 1 |
| Eigenthaler, M; Geiger, J; Schwarz, UR; Walter, U | 1 |
| Boneu, B; Cazenave, JP; Freund, M; Léger, P; Magues, JP | 1 |
| Aronow, WS | 6 |
| Bergman, G; Deutsch, E; Jauhar, R; Parikh, M; Sanborn, TA; Savino, S; Shaknovich, A | 1 |
| Pfister, SM | 1 |
| Boissel, JP; Gent, M; Harker, LA; Pilgrim, AJ | 1 |
| Fitzgerald, DJ; Quinn, MJ | 1 |
| Anlauf, M; Helmchen, U; Tholl, U | 1 |
| Brookes, CI; Sigwart, U | 1 |
| Ikeda, Y | 1 |
| Aguirre, FV; Ligon, RW; Lucore, CL; Mishkel, GJ; Rocha-Singh, KJ | 1 |
| Barsness, G; Bell, MR; Bellot, V; Berger, PB; Garratt, K; Grill, D; Hammes, L; Holmes, DR; Mathew, V; Melby, S; Rihal, CS; Ting, H | 1 |
| Calvin, JE; Klein, LW | 2 |
| David, JL; Limet, R | 1 |
| Algra, A; Kappelle, LJ; Koudstaal, PJ; Stam, J; van Gijn, J; Vermeulen, M | 1 |
| Jafary, FH; Kimmelstiel, CD | 1 |
| Caro, JJ; Migliaccio-Walle, K | 1 |
| van Kranen, RJ | 1 |
| Gryglewski, RJ; Marcinkiewicz, E; Olszanecki, R; Uracz, W; Ziemianin, B | 1 |
| Büttner, HJ; Müller, C; Petersen, J; Roskamm, H | 1 |
| Lees, KR; Overell, JR; Walker, A; Weir, CJ | 1 |
| Garg, A; Hopkinson, N; Radvan, J | 1 |
| Bhatt, DL; Topol, EJ | 2 |
| Miller, JL | 1 |
| Okano, E; Seki, J; Taka, T; Yamamoto, J | 1 |
| Bates, SM; Weitz, JI | 1 |
| Breddin, HK; Graff, J; Harder, S; Kirchmaier, CM; Klinkhardt, U; Mahnel, R; Westrup, D | 1 |
| Asai, F; Inoue, T; Koike, H; Ogawa, T; Sugidachi, A | 1 |
| Cohen, M | 2 |
| Berger, PB | 5 |
| Much, DR; Necciari, J; Nichola, P; Slugg, PH; Smith, WB; Vargas, R | 1 |
| Devulder, B | 1 |
| Bousser, MG; Crassard, I; Niclot, P | 1 |
| Asplund, K | 1 |
| Walvoort, HC | 1 |
| Einecke, D | 6 |
| Keser, C | 1 |
| Barr, JD; Furlan, AJ; Katzan, I; Krieger, D; Markarian, GZ; Masaryk, TJ; Perl, J; Rasmussen, PA; Sila, C | 1 |
| Dunbabin, DW; Hankey, GJ; Sudlow, CL | 2 |
| Diot, E; Gruel, Y; Guilmot, JL | 1 |
| SoRelle, R | 4 |
| Marcoux, JP; Moy, B; Raffel, GD; Wang, JC | 1 |
| Dieter, RS | 2 |
| Golka, K; Huber, J; Roth, E; Schmitt, K | 1 |
| Bell, WR; Bennett, CL; Carwile, JM; Connors, JM; Davidson, CJ; Feldman, MD; Hatfield, AJ; McCarthy, LJ; Moake, JL; Sarode, R; Tarantolo, SR; Tsai, HM | 1 |
| Wood, AJ | 2 |
| Oomen, PH; Tulleken, JE; Zijlstra, JG | 1 |
| Boneu, B; Bossavy, JP; Cadroy, Y; Sagnard, L; Sakariassen, K; Thalamas, C | 1 |
| Fork, FT; Lafolie, P; Lindgärde, F; Tóth, E | 1 |
| Bhatt, DL; Hacke, W; Hirsch, AT; Ringleb, PA; Topol, EJ | 2 |
| Curran, SC; Herrmann, HC; Hirshfeld, JW; Klugherz, BD; Kolansky, DM; Magness, K; Wilensky, RL | 1 |
| Block, PC | 1 |
| Chen, AH; Frangos, SG; Sumpio, B | 1 |
| Janzon, L | 1 |
| Dillon, JC; Dillon, WC; Eckert, GJ; Ritchie, ME | 1 |
| Bertrand, ME; Gershlick, AH; Rupprecht, HJ; Urban, P | 1 |
| Chinnakotla, S; Fidler, ME; Hammeke, MD; Leone, JP; Tarantolo, S | 1 |
| Gondek, K; Shah, H | 1 |
| Steinhubl, SR | 4 |
| Blows, LJ; Calver, AL; Dawkins, KD; Gray, HH; Harmer, S; Morgan, JH; Simpson, IA | 1 |
| Hohlfeld, T | 1 |
| Frelinger III, AL; Furman, MI; Michelson, AD | 1 |
| Jarvis, B; Simpson, K | 1 |
| Gebauer, MU; Haeberli, A; Julmy, F; Meyer, BJ; Moshfegh, K; Redondo, M; Wuillemin, WA | 1 |
| Lins, LE; Svensson, P | 1 |
| Moore, SA; Steinhubl, SR | 1 |
| Fiore, L; Hasbargen, JA; Kaufman, JS; O'Connor, TZ; Perdriset, G | 1 |
| Elmi, F; Peacock, T; Schiavone, J | 1 |
| Bounameaux, H; Gaspoz, JM; Sarasin, FP | 1 |
| Badimon, JJ; Chesebro, JH; Farkouh, ME; Fuster, V; Helft, G; Lev, EI; Osende, JI; Rodriguez, OJ; Worthley, SG; Zaman, AG | 1 |
| Kassler-Taub, KB; Sallière, D | 1 |
| Honig, PK; Trontell, AE | 1 |
| Brooker, JZ | 1 |
| Cheung, RT | 1 |
| Goldstein, MR | 1 |
| Dippel, DW; Limburg, M; Niessen, LW | 1 |
| Fry, JA; Grines, CL | 1 |
| Gallai, V; Paciaroni, M | 1 |
| Brown, MM; McCabe, DJ | 1 |
| Bogousslavsky, J; Devuyst, G | 1 |
| Berger, Y; Carrupt, PA; Mayer, JM; Montseny, JP; Reist, M; Roy-de Vos, M; Testa, B | 1 |
| Bhatt, DL; Kapadia, SR; Topol, EJ; Yadav, JS | 1 |
| Weksler, BB | 1 |
| Bode, C; Nordt, T; Peter, K | 1 |
| Mehta, SR; Yusuf, S | 2 |
| Gawaz, M; Müller, I; Pogatsa-Murray, G; Rüdiger, S; Schömig, A; Seyfarth, M; Wolf, B | 2 |
| Combalbert, J; Herbert, JM; Maffrand, JP; Pascal, M; Pereillo, JM; Picard, C; Savi, P; Uzabiaga, MF | 1 |
| Bilder, G; Bostwick, JS; Byan, L; Costanzo, S; Luo, Y; Natarajan, C | 1 |
| Steinhubl, SR; Van De Graaff, E | 2 |
| Montalescot, G | 1 |
| King, SB | 2 |
| Büller, HR; Fisher, LD; Gent, M | 1 |
| Cannan, CR | 1 |
| Alt, M; Andres, E; Goichot, B; Perrin, AE; Schlienger, JL | 1 |
| Bhatt, DL; Chew, DP; Hacke, W; Hirsch, AT; Ringleb, PA; Topol, EJ | 1 |
| Bennett, JS | 1 |
| Abizaid, AS; Curry, BH; Dangas, G; Kent, KM; Lansky, AJ; Leon, MB; Mehran, R; Paliou, M; Pichard, AD; Satler, LF; Stone, GW | 1 |
| Bick, RL; Scott, RG | 1 |
| Casadebaig, F; Dupin, JP; Gravier, D; Gryglewski, RJ; Hou, G; Madej, J; Swiês, J; Uracz, W | 1 |
| Dunlop, H | 1 |
| Coche, G | 1 |
| Calverley, DC | 1 |
| Cambier, N; Caron, J; Mahieu, M; Rose, C; Trivier, JM | 1 |
| Davis, SM; Donnan, GA | 2 |
| Braun, M; Hermann, A; Rauch, BH; Schrör, K; Weber, AA | 1 |
| Maayani, S; Martinez, R; Schwarz, T; Tagliente, TM | 1 |
| Mitka, M | 1 |
| Bogousslavsky, J | 2 |
| Delesque, N; Guette, F; Herbert, JM; Labouret, C; Lupker, J; Savi, P | 1 |
| Bhargava, B; Kent, KM; Kim, HS; Kollum, M; Kolodgie, FD; Mintz, GS; Virmani, R; Waksman, R | 1 |
| Scheen, AJ | 2 |
| Cheng, JW; Gardner, SF; Hilleman, DE; Howard, PA; Lopez, LM; Mauro, VF; Munger, MA; Nappi, JM; Spinler, SA | 1 |
| Ernst, ME | 1 |
| Auer, J; Berent, R; Eber, B; Maurer, E; Mayr, H; Weber, T | 1 |
| Huber, K; Niessner, A; Niessner, H | 1 |
| Jackson, G | 1 |
| Ajani, AE; Bui, AB; Dieble, R; Gruberg, L; Kent, KK; Lindsay, J; Mintz, GS; Pichard, AD; Pinnow, E; Satler, LF; Taaffe, M; Waksman, R; White, RL | 1 |
| Lechner, K; Meyer, B; Staudinger, T | 1 |
| Dunzendorfer, S; Pechlaner, C; Reinisch, CM; Ricevuti, G; Wiedermann, CJ | 1 |
| Griffo, R | 1 |
| Davis, CJ; Lowry, DR; McKenzie, ME; Nair, GV; Serebruany, VL | 1 |
| Chew, DP; Moliterno, DJ; Mukherjee, D; Raymond, RE; Robbins, M; Yadav, JS | 1 |
| Abbondanzo, SJ; Agans, JM; Bayne, ML; Chintala, MS; Cook, DN; Foster, CJ; Gustafson, E; Lachowicz, JE; Lira, SA; Monsma, FJ; Prosser, DM; Smith, MD; Wiekowski, MT; Zhai, Y; Zhang, FL | 1 |
| Dandurand, M; El-Majjaoui, S; Guillot, B; Pinzani, V; Tournillac, I | 1 |
| Kilaru, PK; Kozman, HA; Schweiger, MJ; Weil, TR | 1 |
| Behar, VS; Broderick, T; Colombo, A; Kandzari, DE; Kereiakes, DJ; Kern, M; Runyon, JP; Safian, RD; Shimshak, T; Sketch, MH; Young, J | 1 |
| Plehn, JF; Solet, DJ; Zacharski, LR | 1 |
| Gershlick, A; Hogrefe, K; Stephens Lloyd, A; Swanson, N | 1 |
| Kurz, HI; Lasala, JM; Taniuchi, M | 1 |
| Dewit, LG; Stewart, FA; te Poele, JA; van der Wal, AF; van Kleef, EM | 1 |
| Alcala, C; Craddock-Royal, B; Maayani, S; Marrero, G; Martinez, R; Schwarz, T; Tagliente, TM | 1 |
| Bouillet, L; Bourrain, JL; Sarrot-Reynauld, F | 1 |
| Marks, AR; Marx, SO | 1 |
| Chrolavicius, S; Fox, KK; Mehta, SR; Tognoni, G; Yusuf, S; Zhao, F | 1 |
| Stables, RH | 1 |
| Bertrand, ME; Chrolavicius, S; Copland, I; Fox, KA; Lewis, BS; Malmberg, K; Mehta, SR; Natarajan, MK; Peters, RJ; Rupprecht, H; Yusuf, S; Zhao, F | 1 |
| Haldemann, R; Lüscher, TF; Szucs, TD | 1 |
| Braun, M; Hohlfeld, T; Schrör, K; Schwippert, B; Tschöpe, D; Weber, AA | 1 |
| Gutersohn, A; Hetzer, R; Mülling, C; Musci, M; Sänger, S; Schaffner, T; Wellnhofer, E; Zurbrügg, HR | 1 |
| Bhatt, DL; Chew, DP; Ellis, SG; Mukherjee, D; Robbins, MA; Roffi, M; Schneider, JP; Topol, EJ | 1 |
| Wehrmacher, WH | 1 |
| Ashley, I; Nara, W; Rosner, F | 1 |
| Verheugt, FW | 8 |
| Chesterman, CN; Fahmy, RG; Khachigian, LM; Kumar, RK; Lowe, HC | 1 |
| Valentín, V | 1 |
| Golledge, P; Robinson, N; Timmis, A | 1 |
| George, JN; Medina, PJ; Sipols, JM | 1 |
| Delanty, N; Kantor, J; Majid, A | 1 |
| Anderson, HV; Assali, AR; Fujise, K; Ghani, M; Hale, S; Moustapha, A; Rosales, OR; Salloum, J; Schroth, G; Sdringola, S; Smalling, RW | 1 |
| Callahan, KP; Gurbel, PA; Malinin, AI; Serebruany, VL; Steinhubl, SR | 1 |
| Paschke, R; Reichenberger, F; Wirtz, H | 1 |
| Makoni, SN | 1 |
| Hansen, DB | 2 |
| Brass, LM | 3 |
| Zusman, RM | 2 |
| Olin, JW | 2 |
| Bajzer, CT; Bhatt, DL; Chew, DP; Kapadia, SR; Mukherjee, D; Roffi, M; Topol, EJ; Yadav, JS; Ziada, KM | 1 |
| Dangas, G | 1 |
| Ashley, SA; Bowley, DM; Chapman, TW; Lambert, AW; Walker, AJ; Wilkins, DC | 1 |
| Lalouschek, W; Lang, W; Müllner, M | 1 |
| Albers, GW; Amarenco, P | 1 |
| Berger, PB; Bertrand, ME; Bhatt, DL; Dangas, G; Ellis, SG; Holmes, DR; L'Allier, PL; Lasala, JM; Moses, JW; Moussa, I; Taniuchi, M; Topol, EJ | 1 |
| Ley, SJ | 2 |
| Allen, D | 1 |
| Black, C; Paterson, KR | 1 |
| Klein, N; Koksch, M; Neugebauer, A; Pfeiffer, D; Roethig, G; Rother, T; Seyfarth, HJ | 1 |
| Guile, SD; Ince, F; Ingall, AH; Kindon, ND; Meghani, P; Mortimore, MP | 1 |
| Agnelli, G | 1 |
| Leys, D | 1 |
| Ciuffetti, G; Lombardini, R; Lupattelli, G; Mannarino, E; Pirro, M | 1 |
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| Dambrink, JH; de Boer, MJ; Ernst, NM; Gosselink, AT; Hoorntje, JC; Miedema, K; Ottervanger, JP; Slingerland, RJ; Suryapranata, H; van 't Hof, AW; Zijlstra, F | 1 |
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| Berger, P; Grines, C; Harrington, RA; Ohman, EM; Popma, JJ; Weitz, JI | 1 |
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| Antman, EM; Ardissino, D; Braunwald, E; De Servi, S; Gibson, CM; Gottlieb, S; McCabe, CH; Montalescot, G; Murphy, SA; Neumann, FJ; Riesmeyer, J; Ruzyllo, W; Weerakkody, G; Wiviott, SD | 1 |
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| Chen, X; Chen, Y; Li, J; Shi, S; Tu, X; Wang, J; Xie, Y | 1 |
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| Berger, K; Diener, HC; Hessel, F; Kreuzer, J; Smala, A | 1 |
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| Braun, OO; Erlinge, D; Jakubowski, JA; James, S; Siegbahn, A; Sugidachi, A; Varenhorst, C; Wallentin, L; Winters, KJ | 1 |
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| Einav, Y; Fefer, P; Hod, H; Lubetsky, A; Matetzky, S; Savion, N; Shenkman, B; Varon, D | 1 |
| Berger, PB; Bruskina, O; Dirschinger, J; Dotzer, F; Kastrati, A; Mehilli, J; Ndrepepa, G; Neumann, FJ; Pache, J; Schömig, A; Seyfarth, M; ten Berg, J | 1 |
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| Delate, T; Johnson, SG; Rogers, K; Witt, DM | 1 |
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| Berger, PB; Bhatt, DL; Fox, KA; Hacke, W; Hankey, GJ; Hart, RG; Hu, T; Topol, EJ | 1 |
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| Angiolillo, DJ; Bass, TA; Bernardo, E; Charlton, RK; Costa, MA; Desai, B; Guzman, LA; Shoemaker, SB; Suzuki, Y; Zenni, MM | 1 |
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| Caputo, RP; Cohen, DJ; Cutlip, DE; Dauerman, HL; Gibson, CM; Gordon, PC; Ho, KK; Kiernan, FJ; Kirtane, AJ; Lopez, JJ; Murphy, SA; Piana, RN; Rinaldi, MJ; Ryan, TJ | 1 |
| Berger, PB; Best, PJ; Brennan, DM; Califf, RM; Dasgupta, A; Steinhubl, SR; Szczech, LA; Topol, EJ | 1 |
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| Berger, PB; Blankenship, JC; Büttner, HJ; Byrne, RA; Dirschinger, J; Graf, I; Iijima, R; Kastrati, A; Khattab, AA; Mehilli, J; Minners, J; Neumann, FJ; Pache, J; Richardt, G; Schömig, A; Schulz, S; Seyfarth, M; Skelding, KA | 1 |
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| Aronow, HD; Berger, PB; Brennan, DM; Steinhubl, SR; Topol, EJ | 1 |
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| Campbell, CL; Oestreich, JH; Smyth, SS | 1 |
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| Fowler, A; Nappi, JM; Pallares, MJ; Powers, ER; Reeves, R; Zwerner, PL | 1 |
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| Barragan, P; Bonello, L; Camoin-Jau, L; De Labriolle, A; Dignat-George, F; Lemesle, G; Paganelli, F; Pakala, R; Pichard, AD; Pinto Slottow, TL; Roy, P; Scheinowitz, M; Steinberg, DH; Waksman, R | 1 |
| Bonello, L; De Labriolle, A; Kent, KM; Lemesle, G; Pichard, AD; Roy, P; Satler, LF; Steinberg, DH; Suddath, WO; Torguson, R; Waksman, R | 1 |
| Ottervanger, JP; Remijn, JA; Slingerland, RJ; Smit, JJ; van 't Hof, AW; van Oeveren, W; Zijlstra, F | 1 |
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| Bonello, L; Kaneshige, K; Kent, KM; Lindsay, J; Okabe, T; Pichard, AD; Pinto Slottow, TL; Roy, P; Satler, LF; Steinberg, DH; Suddath, WO; Torguson, R; Waksman, R; Xue, Z | 1 |
| Abbate, R; Antoniucci, D; Buonamici, P; Gensini, GF; Giusti, B; Gori, AM; Marcucci, R; Paniccia, R; Saracini, C; Sestini, I | 1 |
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| Antonino, MJ; Bliden, KP; Butler, K; Eikelboom, JW; Gurbel, PA; Henderson, D; Husted, S; Kereiakes, DJ; Nielsen, T; Patel, DV; Rasmussen, L; Sabe-Affaki, G; Storey, RF; Tantry, US; Teng, R; Wei, C | 1 |
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| Gao, F; Jia, de A; Liu, XL; Nie, B; Shen, H; Wang, ZJ; Yan, ZX; Yang, SW; Yu, M; Zhou, YJ | 1 |
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| Ben-Dor, I; Collins, SD; Delhaye, C; Gaglia, MA; Gonzalez, MA; Hanna, N; Kent, KM; Maluenda, G; Pichard, AD; Satler, LF; Suddath, WO; Syed, AI; Torguson, R; Wakabayashi, K; Waksman, R; Xue, Z | 1 |
| Banning, AP; Bedogni, F; Bhindi, R; Biondi Zoccai, GG; Brambilla, N; Lanotte, S; Latini, RA; Laudisa, ML; Pizzocri, S; Testa, L; Valgimigli, M; Van Gaal, WJ | 1 |
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| Chung, CP; Daugherty, JR; Griffin, MR; Hall, K; Kaltenbach, LA; Murray, KT; Ray, WA; Smalley, WE; Stein, CM | 1 |
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| Cho, DK; Cho, JR; Cho, YH; Choi, D; Hong, MK; Jang, Y; Jeon, DW; Kim, BK; Kim, J; Kim, JS; Ko, YG; Lee, CJ; Lee, NH; Lee, SH; Oh, SJ; Yang, JY | 1 |
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| Arkadir, D; Cohen, JE; Itshayek, E; Leker, RR; Rosenberg, S | 1 |
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| Abildstrøm, SZ; Andersson, C; Charlot, M; Fosbøl, EL; Gislason, GH; Hansen, PR; Hvelplund, A; Køber, L; Madsen, JK; Sørensen, R; Torp-Pedersen, C | 1 |
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| Cho, YR; Hong, BY; Kim, HS; Kim, HW; Ko, YJ; Lee, JI; Lim, SH | 1 |
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| Bhatt, DL; Brennan, DM; Easton, DJ; Fox, KA; Hamm, CW; Hankey, GJ; Johnston, SC; Mak, KH; Montalescot, G; Steinhubl, SR; Topol, EJ; Weber, M | 1 |
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| Anzaha, G; Barthélémy, O; Bellemain-Appaix, A; Beygui, F; Caron, C; Cayla, G; Chastre, T; Collet, JP; Galier, S; Gallois, V; Hulot, JS; Montalescot, G; Pena, A; Silvain, J; Vignalou, JB | 1 |
| Alexopoulos, D; Athanassiadou, A; Davlouros, P; Dimitropoulos, G; Hahalis, G; Kassimis, G; Stavrou, EF; Xanthopoulou, I | 1 |
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| Alessi, MC; Bonnet, G; Bonnet, JL; Cuisset, T; Deharo, P; Dutour, A; Gaborit, B; Lambert, M; Loundou, AD; Morange, PE; Pankert, M; Quilici, J; Valéro, R; Verdier, V | 1 |
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| Armstrong, PW; Clemmensen, P; Cornel, JH; Cyr, DD; Fox, KA; Hochman, JS; Huber, K; McGuire, DK; Neely, ML; Ohman, EM; Prabhakaran, D; Roe, MT; White, HD; Zamoryakhin, D | 1 |
| Neumann, FJ; Pache, G; Ruile, P; Schoechlin, S | 1 |
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| Ding, SL; Fang, D; Fang, Q; Gan, XD; Li, KY; Peng, S; Wan, J; Wei, BZ | 1 |
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| Che, JJ; Chen, KY; Li, GP; Liu, T; Rha, SW; Xu, LX; Zheng, XT | 1 |
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| Ensminger, SM; Heim, C; Koch, N; Motsch, B; Ramsperger-Gleixner, M; Weyand, M | 1 |
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| Ghim, JL; Kim, DH; Kim, EY; Kim, HS; Lim, Y; Oh, M; Shin, JG | 1 |
| Anderson, RA; Freeman, PM; Hinz, C; James, PE; Kinnaird, TD; Moschonas, KE; O'Donnell, VB | 1 |
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| Althaus, AB; Chang, P; Dovirak, O; O'Halloran, TD; Taylor, KN; Wagner, AA | 1 |
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| Backman, J; Bergmann, TK; Brosen, K; Filppula, AM; Launiainen, T; Nielsen, F | 1 |
| Fortmann, S; Kaczmarski, J; Kuliczkowski, W; Serebruany, V; Sliwka, J; Steter, D; Zembala, M; Zysko, D | 1 |
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| Ardissino, D; Bianchessi, M; Boffetti, F; Caporale, V; Casu, G; Cereda, M; Cocci, A; Coppini, L; Crocamo, A; del Giudice, F; Demola, MA; Guidorossi, A; Manzalini, C; Marziliano, N; Merlini, PA; Notarangelo, MF; Orsini, F; Pigazzani, F; Pirola, D | 1 |
| Chandrasekhar, J; Froeschl, M; Hibbert, B; May, ML; Mehran, R; So, D | 1 |
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| Ajjan, RA; Dockrell, DH; Ecob, R; Faulkner, RE; Judge, HM; Khan, H; Outteridge, SN; Phoenix, F; Sabroe, I; Sangha, GK; Storey, RF; Thomas, MR; West, LE | 1 |
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| Barbieri, L; Bellomo, G; De Luca, G; Marino, P; Nardin, M; Pergolini, P; Rolla, R; Sartori, C; Suryapranata, H; Verdoia, M | 1 |
| Ikeda, Y; Isshiki, T; Kimura, T; Kitagawa, K; Miyazaki, S; Nakamura, M; Nanto, S; Nishikawa, M; Ogawa, H; Saito, S; Takayama, M; Tanaka, Y; Yokoi, H | 1 |
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| Horenstein, RB; Jiang, XL; Lesko, LJ; Lewis, JP; Peletier, LA; Samant, S; Schmidt, S; Shuldiner, AR; Yerges-Armstrong, LM | 1 |
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| Dhillon, SS; Harris, K; Karnyski, J; Kumar, A | 1 |
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| Ahmed, O; Daniel, E; Grunwald, JE; Maguire, MG; Martin, DF; Ying, GS | 1 |
| Cheng, K; Guo, WY; Liu, LP; Si, R; Wang, Y; Yuan, M | 1 |
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| Benavente, OR; Field, TS; Hart, RG; McClure, LA; Odden, MC; Peralta, CA; Pergola, PE; Sawaya, BP; White, CL | 1 |
| Abtan, J; Amour, J; Barthélémy, O; Brugier, D; Collet, JP; Kerneis, M; Leprince, P; Martin, R; Mercadier, A; Montalescot, G; O'Connor, SA; Silvain, J | 1 |
| Dannenberg, L; Kelm, M; Polzin, A; Sophia Popp, V; Zeus, T | 1 |
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| Cabrera-Fuentes, HA; Cherepanov, V; Kim, MH; Serebruany, VL | 1 |
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| Chen, GM; Lu, J; Shao, H; Xu, YT; Zhan, Y; Zhang, HJ | 1 |
| Antman, EM; Close, SL; Collet, JP; Delaney, JT; Duvvuru, S; Hulot, JS; Man, M; Mega, JL; Murphy, SA; Paré, G; Price, MJ; Sabatine, MS; Sibbing, D; Simon, T; Sundseth, SS; Trenk, D; Walker, JR; Wiviott, SD | 1 |
| Al Meman, AA; Khalaf, H; Rasool, S | 1 |
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| Chang, K; Choi, YS; Chung, WB; Chung, WS; Kim, HY; Kim, JY; Kwon, A; Lee, MY; Park, CS; Seung, KB | 1 |
| Ambrus, JL; Chichelli, T; Ching, M; Janicke, D; Munschauer, F; Sawyer, R; Sternberg, D; Sternberg, Z; Yu, J | 1 |
| Brilliant, MH; Burkley, B; Denny, JC; Gong, Y; Hoh, BL; Ingram, C; Johnson, JA; Kitchner, TE; Langaee, TY; Linneman, JG; McDonough, CW; Mocco, J; Mummareddy, N; Roden, DM; Royster, AJ; Shaffer, CM; Sheehan, TO; Stephens, ML; Waters, MF; Zuckerman, SL | 1 |
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| Alessi, MC; Angiolillo, DJ; Aradi, D; Beigel, R; Berdagué, P; Campo, G; Combescure, C; Cuisset, T; Fontana, P; Gawaz, M; Geisler, T; Gori, AM; Gurbel, PA; Hochholzer, W; Janssen, PW; Marcucci, R; Neumann, FJ; Reny, JL; Ten Berg, J; Yong, G | 1 |
| Bougouin, W; Cariou, A; Dumas, F; Gouffran, G; Jakamy, R; Joffre, J; Lamhaut, L; Rosencher, J; Varenne, O | 1 |
| Croce, KJ; Falcão, FC; Falcão, JL; Lemos, PA; Medeiros, F; Mont'Alverne-Filho, JR; Nicolau, JC; Rodrigues-Sobrinho, CR; Serruys, PW; Silva, RC; Valgimigli, M | 1 |
| Bali, DE; El Maghraby, GM; Osman, MA | 1 |
| Axelsson, C; Bremer, A; Claesson, A; Herlitz, J; Jimenez-Herrera, M; Karlsson, T; Ravn-Fischer, A; Strandmark, R | 1 |
| Basford, MA; Bowton, E; Cowan, JD; Danciu, I; Denny, JC; Field, JR; Gregg, W; Harrell, FE; Peterson, JF; Pulley, JM; Roden, DM; Schildcrout, JS; Shi, Y | 1 |
| Ajjan, RA; Angiolillo, DJ; Bass, TA; Bhatti, M; Cho, JR; DeGroat, C; Franchi, F; Guzman, LA; King, R; Phoenix, F; Rollini, F; Tello-Montoliu, A; Zenni, MM | 1 |
| Armstrong, PW; Beaven, AW; Blackwell, KL; Cyr, DD; Eckart, D; Fox, KA; Houterloot, L; Morse, MA; Ohman, EM; Onken, JE; Prabhakaran, D; Ready, NE; Roe, MT; Schulte, PJ; Strickler, JH; White, HD; Winters, KJ; Wiviott, SD; Zafar, SY; Zamoryakhin, D | 1 |
| Brodie, BR; Clemmensen, P; Cox, DA; Dangas, GD; Duffy, PL; Henry, TD; Kirtane, AJ; Litherland, C; Maehara, A; Mazzaferri, EL; Mehran, R; Metzger, DC; Neumann, FJ; Rinaldi, MJ; Schoos, MM; Stone, GW; Stuckey, TD; Weisz, G; Witzenbichler, B; Yu, J | 1 |
| Braun, D; Braun, S; Hausleiter, J; Kastrati, A; Knipper, A; Massberg, S; Mehilli, J; Orban, M; Petzold, T; Schulz, S; Sibbing, D | 1 |
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| Angelkov, LG; Babić, RM; Čalija, BM; Čolić, MD; Grdinić, AG; Kruzliak, P; Marinković, JM; Milosavljević, BM; Mrdović, IB; Sagić, DŽ | 1 |
| Andò, G; Ariotti, S; Costa, F; De Palma, R; Giatti, S; Guastaroba, P; Moscarella, E; Oreto, G; Tijssen, JG; Valgimigli, M; Zijlstra, F | 1 |
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| Di, XH; Jiang, N; Song, LX; Xu, J; Xu, L; Xu, XT; Yang, YG; Zhang, M; Zhao, GT | 1 |
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| Desch, S; Eitel, I; Empen, K; Ferenc, M; Fuernau, G; Hambrecht, R; Hausleiter, J; Hennersdorf, M; Limbourg, T; Neumann, FJ; Olbrich, HG; Orban, M; Pöss, J; Richardt, G; Schneider, S; Schuler, G; Thiele, H; Werdan, K; Zeymer, U | 1 |
| Cleator, JH; Danciu, I; Denny, JC; Field, JR; Johnson, DC; Johnson, KB; Laposata, M; McPherson, JA; Peterson, JF; Pulley, JM; Roden, DM; Schildcrout, JS; Shi, Y; Unertl, KM | 1 |
| Assali, A; Codner, P; Eisen, A; Kornowski, R; Lev, EI; Orvin, K; Perl, L; Vaknin-Assa, H; Zemer-Wassercug, N | 1 |
| Apostolovic, SR; Jankovic, SM; Jevtovic-Stoimenov, T; Konstantinovic, SS; Lilic, J; Nikolic, VN; Pavlovic, M; Stokanovic, D; Zivkovic, VS; Zvezdanovic, JB | 1 |
| Fu, Q; Huang, YJ; Zhang, N; Zhang, Q; Zhu, K | 1 |
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| Angiolillo, DJ; Berger, PB; Cannon, CP; Price, MJ; Reed, GW; Tanguay, JF; Teirstein, PS; Waalen, J | 1 |
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| Agostoni, P; Baan, J; Bennaghmouch, N; Collet, JP; den Heijer, P; Deneer, VH; Hassell, M; Huber, K; Kelder, JC; Kievit, PC; Latib, A; Maisano, F; Nijenhuis, VJ; Onorati, F; Stella, PR; Ten Berg, JM; van 't Hof, A; van den Heuvel, AF; van der Harst, P; van der Kley, F; van Kuijk, JP; Veenstra, L | 1 |
| Jilma, B; Jilma-Stohlawetz, P; Quehenberger, P; Ratzinger, F; Schörgenhofer, C | 1 |
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| Cheng, W; Lin, J; Wang, C; Wu, L; Yi, X; Zhou, Q | 1 |
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| Chen, J; Gao, RL; He, C; Liu, R; Ma, YL; Meng, XM; Song, L; Song, Y; Tang, XF; Wang, M; Xu, B; Xu, JJ; Yao, Y; Yuan, JQ; Zhang, JH | 1 |
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| Bode, C; Gibson, CM; James, S; Mundl, H; Ohman, EM; Plotnikov, A; Povsic, TJ; Roe, MT; Steg, PG; Welsh, R | 1 |
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| Armstrong, PW; Boden, WE; Chin, CT; Corbalán, R; Dalby, AJ; Fox, KA; Gottlieb, S; Leiva-Pons, JL; Neely, B; Neely, ML; Ohman, EM; Prabhakaran, D; Roe, MT; Schiele, F; White, HD; Winters, KJ | 1 |
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| Benezet, JF; Cayla, G; Cornillet, L; de La Coussaye, JE; Fabbro-Peray, P; Lattuca, B; Leclercq, F; Ledermann, B; Macia, JC; Messner-Pellenc, P; Schmutz, L | 1 |
| Bourdakis, A; Charmpas, C; Christogiannis, Z; Dimoulis, N; Draganigos, A; Efthimiadis, I; Giannakoulas, G; Giatrakos, I; Giogiakas, V; Goudevenos, JA; Goumas, G; Hatziathanasiou, G; Kalantzi, KI; Kazakos, E; Kipouridis, N; Konstantinou, S; Milionis, H; Nikolopoulos, D; Ntalas, IV; Panagiotakos, DB; Peltekis, L; Prokopakis, N; Sinteles, I; Stroumbis, C; Terzoudi, K; Thoma, M; Tselepis, AD; Tsilias, K; Tsoumani, ME; Vakalis, I; Vardakis, K; Vasilakopoulos, V; Vemmos, K; Voukelatou, M; Xaraktsis, I | 1 |
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| Anstrom, KJ; Armstrong, PW; Boden, WE; Clapp-Channing, N; Cowper, P; Davidson-Ray, L; Fakhouri, W; Fox, KA; Gašparović, V; Hochman, JS; Kaul, P; Knight, JD; Mark, DB; McCollam, P; Ohman, EM; Prabhakaran, D; Roe, MT; White, HD | 1 |
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| Benzeroual, D; Elharda, CA; Hattaoui, ME; Oualim, S | 1 |
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| Cutlip, DE; D'Agostino, RB; Hsieh, WH; Kereiakes, DJ; Massaro, JM; Mauri, L; Stefanescu Schmidt, AC; Yeh, RW | 1 |
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| Blankenberg, S; Brieger, D; Chen, JY; Goodman, SG; Granger, CB; Grieve, R; Maguire, A; Nicolau, JC; Pocock, SJ; Requena, G; Simon, T; Vega, AM; Yasuda, S | 1 |
| Danielak, D; Graczyk-Szuster, A; Główka, F; Karaźniewicz-Łada, M; Komosa, A; Lesiak, M; Tomczak, A | 1 |
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| Chen, W; Li, J; Lin, J; Lin, Y; Liu, L; Meng, X; Ou, L; Wang, A; Wang, D; Wang, Y; Zhao, X | 1 |
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| Filonenko, IV; Grinshtein, IY; Grinshtein, YI; Kosinova, AA; Savchenko, AA | 1 |
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| Barbato, E; Geene, SMC; Janssen, PWA; Mol, EA; Ten Berg, JM | 1 |
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| Fang, W; Gan, Q; Han, W; Hou, X; Liu, Y | 2 |
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| Chen, XP; Li, MP; Tang, J; Zhang, YJ | 1 |
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| Chen, X; Cui, H; Du, W; Ji, L; Li, X; Liu, T; Su, J; Tong, M; Xia, Y; Xu, H; Yang, J; Yao, Q; Yu, J; Yu, Q; Zhang, J; Zheng, Y; Zhu, H; Zhu, Y | 1 |
| Bauer, JS; Choi, PA; Okonkwo, DO; Panczykowski, DM; Parry, PV; Puccio, AM; Zusman, BE | 1 |
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| Kanic, V; Kanic, Z; Kompara, G; Markota, A; Penko, M; Vollrath, M | 1 |
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| Cao, Y; Chen, G; Chen, W; Li, H; Li, J; Li, X; Lin, Y; Liu, L; Meng, X; Pan, Y; Wang, D; Wang, Y; Wang, Z; Wu, J; Xu, Y; Zhang, G; Zhao, X | 1 |
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| Alfredsson, J; Armstrong, PW; Bhatt, DL; Cornel, JH; Fox, KA; Goodman, SG; Mahaffey, KW; Neely, B; Neely, ML; Ohman, EM; Prabhakaran, D; Roe, MT; Tricoci, P; White, HD; Winters, KJ | 1 |
| Amann, M; Bömicke, T; Hochholzer, W; Neumann, FJ; Stratz, C; Valina, CM | 1 |
| Bhatt, DL; Day, JRS; Gibson, CM; Hamm, CW; Mahaffey, KW; Parker, WA; Prats, J; Price, MJ; Steg, PG; Stone, GW; Storey, RF; White, HD | 1 |
| Huang, Y; Li, M; Shi, X; Wang, H; Xuan, L; Zhang, N; Zhou, T | 1 |
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| Cho, JY; Choi, YJ; Jang, IJ; Jo, HJ; Jung, HC; Kim, N; Lee, DH; Nam, RH; Park, JH; Park, YS; Shin, CM; Yoon, H | 1 |
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| Brown, EB; Cyr, DD; Goldstein, SA; Hamm, CW; Lüscher, TF; Neely, M; Newby, LK; Ohman, EM; Roe, MT; White, HD | 1 |
| Becker, RC; Cannon, CP; Hagström, E; Himmelmann, A; James, SK; Katus, HA; Lindholm, D; López-Sendón, JL; Maurer, G; Siegbahn, A; Steg, PG; Storey, RF; Wallentin, L | 1 |
| Adeeb, N; Alturki, A; Foreman, PM; Griessenauer, CJ; Harrigan, MR; Levy, EI; Moore, JM; Motiei-Langroudi, R; Ogilvy, CS; Shallwani, H; Siddiqui, AH; Thomas, AJ | 1 |
| Badri, P; Bow, D; Fischer, V; Fu, W; Shebley, M | 1 |
| Dixon, SR; Gurm, HS; Khandelwal, A; LaLonde, TA; Seth, M; Sukul, D | 1 |
| Chen, W; Jing, J; Johnston, SC; Li, H; Liu, L; Meng, X; Pan, Y; Wang, D; Wang, Y; Zhao, X | 1 |
| Eichelberger, B; Gremmel, T; Kopp, CW; Koppensteiner, R; Lang, IM; Panzer, S; Pultar, J; Seidinger, D; Wadowski, PP | 1 |
| Barmparas, G; Bosarge, P; Brown, CV; Bukur, M; Carrick, MM; Catalano, RD; Coimbra, R; Holly-Nicolas, J; Inaba, K; Kaminski, S; Klein, AL; Kobayashi, L; Kopelman, T; Ley, EJ; Martinez, EM; Moore, FO; Murry, J; Nirula, R; Paul, D; Quick, J; Rivera, O; Schreiber, M | 1 |
| Bi, Q; Fu, P; Guo, F; Qiao, M; Song, Z; Wang, Y | 1 |
| Fiolaki, A; Giannopoulos, S; Katsanos, AH; Kosmidou, M; Kyritsis, AP; Moschonas, IC; Papadaki, S; Tselepis, AD | 1 |
| Colgan, MP; Coughlan, T; Doherty, CP; Egan, B; Feeley, TM; Hamilton, G; Harbison, JA; Kinsella, JA; Madhavan, P; McCabe, DJH; Moore, DJ; Moran, N; Murphy, RP; O'Neill, D; O'Neill, SM; Oliver Tobin, W; Ronan Collins, D; Saqqur, M; Tierney, S | 1 |
| Bellomo, G; Carriero, A; Daffara, V; De Luca, G; Marino, P; Pergolini, P; Rolla, R; Verdoia, M | 1 |
| Boyd, A; Chambers, A; Chanas, T; Coons, JC; Eckardt, J; Ensor, CR; Iasella, CJ; Lemon, LS; Lyons, J; Merkel, A; Rihtarchik, L; Smith, R; Wang, N; Williams, K | 1 |
| Cao, S; Chen, BL; Fan, L; Liu, M; Liu, ZQ; Xiao, FY; Zhang, W; Zhou, G; Zhou, HH | 1 |
| Arima, Y; Hokimoto, S; Ishii, M; Ito, M; Iwashita, S; Kaikita, K; Kojima, S; Mitsuse, T; Oimatsu, Y; Sueta, D; Takahashi, A; Tsujita, K; Yamamoto, E | 1 |
| Arya, V; Mishra, P; Reynolds, KS; Younis, IR; Zhao, P | 1 |
| Cai, LL; Cong, YL; Deng, XL; Guan, J; Li, YR; Liu, QY; Tian, KP; Zheng, BX | 1 |
| Chen, WC; Chuah, SK; Hsu, PI; Huang, YT; Lin, KH; Sun, WC; Tsai, TJ; Wu, DC | 1 |
| Choi, CW; Jeong, DI; Kang, DH; Kim, HW; Kim, WC; Lim, TW; Ryu, DG; Shin, JG | 1 |
| Hattori, M; Ito, H; Kawakami, M; Matsuo, M; Takahashi, N; Takemura, Y; Yamazaki, M | 1 |
| Anstrom, KJ; Bagai, A; Cohen, DJ; Effron, MB; Henry, TD; McCoy, LA; Peterson, ED; Schulte, PJ; Stone, GW; Wang, TY; Zettler, ME | 1 |
| Becker, RC; Budaj, A; Cannon, CP; Cornel, JH; Ducrocq, G; Held, C; Himmelmann, A; Husted, S; James, SK; Katus, HA; Lopes, RD; Schulte, PJ; Sorbets, E; Steg, PG; Storey, RF; Wallentin, L | 1 |
| Jang, HJ; Kang, WC; Kim, TH; Kwon, SW; Lee, K; Moon, J; Oh, PC; Park, HW; Park, SD; Suh, J | 1 |
| Alexopoulos, D; Davlouros, P; Deftereos, S; Goudevenos, J; Hamilos, M; Kanakakis, I; Lekakis, J; Sitafidis, G; Vavouranakis, M; Xanthopoulou, I | 1 |
| Bessen, SY; Chauhan, NB; Columbo, JA; Goodney, PP; Kang, R; Lambour, AJ; Linshaw, DL; Riblet, NBV; Stone, DH; Sundling, RA | 1 |
| Apruzzese, PK; Cutlip, DE; Kereiakes, DJ; Massaro, JM; Mauri, L; Secemsky, EA; Steg, PG; Yeh, RW | 1 |
| Adeeb, N; Griessenauer, CJ; Gupta, R; Moore, JM; Ogilvy, CS; Patel, AS; Shallwani, H; Siddiqui, A; Thomas, AJ; Youn, R | 1 |
| Chang, KS; Hong, YJ; Jeong, MH; Kim, HK; Kim, JH; Kim, MC; Kim, SS; Lim, HC; Lim, KS; Park, KH | 1 |
| Bhatt, DL; Grove, EL; Kristensen, SD; Pareek, M; Ten Berg, JM | 1 |
| Alessi, MC; Bassez, C; Bonnet, G; Bonnet, JL; Cuisset, T; Deffarges, S; Deharo, P; Fourcade, L; Johnson, TW; Lambert, M; Morange, PE; Mouret, JP; Quilici, J; Verdier, V | 1 |
| Boersma, E; Diletti, R; Fam, JM; Felix, CM; IJsselmuiden, AJJ; Lansink, WJ; Onuma, Y; Regar, ES; Smits, PC; van Geuns, RJM; Vlachojannis, GJ; Zijlstra, F | 1 |
| Cai, Y; Chen, S; Du, C; Gao, Y; Lai, W; Qin, C; Yang, C; Zhou, J | 1 |
| Armstrong, PW; Gershlick, A; Halvorsen, S; Huber, K; Shavadia, J; Steg, PG; Van de Werf, F; Welsh, R; Zheng, Y | 1 |
| Aldazabal, A; Cerrato, E; Echavarría-Pinto, M; Escaned, J; Fernández-Ortiz, A; Gonzalo, N; Jimenez-Quevedo, P; Macaya, C; Mejia-Renteria, H; Nombela-Franco, L; Núñez-Gil, IJ; Quirós, A; Rumoroso, JR; Ryan, N; Salinas, P | 1 |
| Al-Qoofi, F; Chamandi, C; Côté, M; Dumont, E; Garcia Del Blanco, B; Généreux, P; Maluenda, G; Masson, JB; Paradis, JM; Pelletier, M; Rodés-Cabau, J; Serra, V; Thoenes, M; Webb, JG; Welsh, RC | 1 |
| Ahn, JM; Choi, HI; Kang, SH; Kang, SJ; Kim, YH; Lee, CW; Lee, PH; Lee, SW; Park, DW; Park, SJ; Park, SW | 1 |
| Godier, A; Houssany-Pissot, S; Martin, AC; Taylor, G; Zlotnik, D | 1 |
| Chase, MR; Hanson, ME; Heithoff, K; Mavros, P; Patel, MD; Simpson, RJ; Wu, D | 1 |
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| Choi, KN; Jang, JS; Jin, HY; Kim, DK; Kim, DS; Park, YA; Seo, JS; Shin, HC; Yang, TH | 1 |
| Bil, J; Bojko, K; Gil, RJ; Górny, J; Januszko-Giergielewicz, B; Kern, A; Sienkiewicz, E | 1 |
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| Abnousi, F; Bhatt, DL; Deliargyris, EN; Desai, M; Ding, VY; Généreux, P; Gibson, CM; Hamm, CW; Harrington, RA; Mahaffey, KW; Prats, J; Price, MJ; Steg, PG; Stone, GW; Sundaram, V; White, HD; Yang, L; Yong, CM | 1 |
| Armstrong, PW; Bhatt, DL; Cyr, DD; Dalby, AJ; Fox, KAA; Gottlieb, S; Magnus Ohman, E; McGuire, DK; Prabhakaran, D; Roe, MT; Ruzyllo, W; White, HD; Winters, KJ; Wiviott, SD | 1 |
| Aquino, M; Baber, U; Baker, BA; Bansilal, S; Chandrasekhar, J; DeFranco, A; Effron, M; Henry, TD; Kapadia, S; Keller, S; Kini, A; Marrett, E; Mehran, R; Muhlestein, JB; Pocock, S; Poddar, KL; Rao, SV; Sartori, S; Strauss, C; Toma, C; Weintraub, W; Weiss, S | 1 |
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| Bognetti, P; Cardile, A; De Servi, S; Demarchi, A; Ferlini, M; Frattini, S; Grieco, N; Ielasi, A; Lettieri, C; Mafrici, A; Musumeci, G; Rossini, R; Russo, A; Sponzilli, C; Vecchiato, C; Visconti, LO | 1 |
| Becker, RC; Cannon, CP; Davoudi, F; Diercks, DB; Himmelmann, A; James, SK; Lim, ST; Pollack, CV; Schulte, PJ; Spinar, J; Steg, PG; Storey, RF; Wallentin, L | 1 |
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| Chang, S; Chang, Y; Lu, S; Sun, Q; Zhang, Y | 1 |
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| Chen, Q; Geng, G; Han, W; Hao, Y; Hao, Z; Jia, K; Liu, H; Liu, L; Liu, Y; Wang, D; Zhou, Y | 1 |
| Huang, C; Wang, Y; Wu, Y; Xu, W; Yan, H; Zhang, L; Zhou, Y; Zhu, J; Zhu, W | 1 |
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| Bang, CS; Hong, KS; Hong, MK; Jeong, H; Jung, MH; Kim, CY; Park, SM | 1 |
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| Buckley, CE; Duconge, J; Hernandez-Suarez, DF; Lopez-Candales, A; Melin, K; Scott, SA; Tomey, MI | 1 |
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| Jiang, M; You, JHS | 1 |
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| Borse, MS; Dong, OM; Farley, JF; Lee, CR; Polasek, MJ; Stouffer, GA | 1 |
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| Elisaf, M; Manios, E; Milionis, H; Ntaios, G; Papavasileiou, V; Spengos, K; Vemmos, K | 1 |
| Cong, Y; Li, F; Li, Z; Liu, X; Ming, T; Sun, H; Zhang, J | 1 |
| Fu, DL; Gao, YX; Li, XL; Liu, XF; Lu, HK; Peng, WH; Wang, Q; Wang, Y; Yang, P; Zhang, H; Zhao, TT; Zheng, JG | 1 |
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| Aquino, M; Baber, U; Baker, BA; Chandrasekhar, J; Dangas, G; DeFranco, A; Effron, MB; Faggioni, M; Farhan, S; Henry, TD; Kapadia, S; Keller, S; Kini, AS; Mehran, R; Muhlestein, JB; Pocock, S; Rao, S; Sartori, S; Strauss, C; Toma, C; Vogel, B; Weintraub, W; Weiss, S | 1 |
| Ben-Yehuda, O; Brodie, BR; Cox, DA; Duffy, PL; Généreux, P; Gurbel, PA; Henry, TD; Kirtane, AJ; Litherland, C; Mazzaferri, EL; Mehran, R; Metzger, DC; Neumann, FJ; Rinaldi, MJ; Simonton, CA; Stone, GW; Stuckey, TD; Weisz, G; Witzenbichler, B | 1 |
| Adriaenssens, T; Bernlochner, I; Byrne, RA; Colleran, R; Emmer, R; Fischer, M; Giacoppo, D; Han, Y; Harada, Y; Ibrahim, T; Jacobshagen, C; Kastrati, A; Kufner, S; Lahmann, AL; Laugwitz, KL; Lohaus, R; Maeng, M; Mayer, K; Mehilli, J; Michel, J; Morath, T; Neumann, FJ; Schulz-Schüpke, S; Schunkert, H; Seyfarth, M; Ten Berg, JM; Tölg, R; Wöhrle, J; Wolk, A; Zrenner, B | 1 |
| Chen, S; Geng, Y; Gu, J; Hao, Q; Qi, P; Wang, H; Wang, L; Zhang, Y | 1 |
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| Abdul Kader, MASK; Amin, AM; Ibrahim, B; Kah Hay, Y; Mohamed Noor, DA; Mostafa, H; Sheau Chin, L | 1 |
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| Abizaid, A; Bhatt, DL; Colombo, A; Feres, F; Gilard, M; Hong, MK; Kim, HS; Morice, MC; Palmerini, T; Piccolo, R; Stone, GW; Valgimigli, M; Windecker, S | 1 |
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| Angiolillo, DJ; Barozzi, C; Bartorelli, A; Bellandi, F; Calabrò, P; Capodanno, D; Cattaneo, M; De Carlo, M; De Servi, S; Della Riva, D; Genereux, P; Leoncini, M; Maffeo, D; Palmerini, T; Palmieri, C; Piscione, F; Tomasi, L; Toso, A | 1 |
| Han, FS; He, H; Ke, BB; Li, X; Li, Y; Zeng, YJ | 1 |
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| Bash, LD; Patel, MD; Simpson, RJ; Vyas, A | 1 |
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| Fairley, S; Harding, SA; Holley, A; Larsen, PD; Simmonds, M; Wilkins, B | 1 |
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| Borczuk, P; Ornam, JV; Pruitt, P | 1 |
| Amin, AM; Ibrahim, B; Kah Hay, Y; Mohamed Noor, DA; Mostafa, H; Sheau Chin, L; Sk Abdul Kader, MA; Teh, CH | 1 |
| Channar, PA; El-Seedi, HR; Faisal, M; Larik, FA; Saeed, A; Shahzad, D | 1 |
| Chen, SB; Ji, WJ; Li, YM; Liu, JX; Liu, XL; Lu, RY; Ma, YQ; Sun, J; Yang, GH; Zhang, YY; Zhao, JH; Zhou, X | 1 |
| Li, KC; Yu, SH; Zhuge, BZ | 1 |
| Athanasiou, A; Spartalis, E; Spartalis, M; Tzatzaki, E | 1 |
| Guirgis, M; Jansen, S; Thompson, P | 1 |
| Burchardt, P; Danielak, D; Graczyk-Szuster, A; Główka, F; Karaźniewicz-Łada, M; Komosa, A; Kruszyna, Ł; Lesiak, M | 1 |
| Han, Y; Li, C; Li, J; Li, Y; Qi, J; Tang, Y; Wang, H | 1 |
| Cheng, JH; Feng, ZW; Hu, ZH; Li, XY; Lv, QZ; Shi, HT; Wang, QB; Wang, Z; Wu, HY; Xie, XQ; Xu, Q; Xue, Y | 1 |
| Fu, WX; He, RX; Jing, QM; Liu, HW; Liu, YJ; Wang, XZ; Yuan, WJ; Zhang, L; Zhou, TN | 1 |
| Ahn, S; Cho, MJ; Cho, S; Ha, J; Kim, SY; Lee, J; Min, SI; Min, SK | 1 |
| Bagai, A; Booker, J; Cantor, WJ; Cheema, AN; Crawford, JJ; Dehghani, P; Goodman, SG; Harenberg, S; Kelly, S; Lavi, S; Lavoie, A; Mehta, SR; Zimmermann, RH | 1 |
| An, JH; Kim, EJ; Kim, SG; Lee, DW; Lee, JH; Lee, SG; Shim, KS | 1 |
| Chen, X; Liu, Z; Ren, J; Sun, T; Wang, J; Wang, X; Zhang, J | 1 |
| Chai, HT; Chang, HW; Chen, CJ; Chen, KH; Chua, S; Chung, SY; Lee, WC; Liu, CF; Sung, PH; Tong, MS; Yip, HK | 1 |
| Lowenstern, A; Newby, LK | 1 |
| Brener, SJ; Dangas, GD; Deliargyris, EN; Généreux, P; Giustino, G; Kirtane, AJ; Mehran, R; Pocock, SJ; Prats, J; Redfors, B; Stone, GW | 1 |
| Agrawal, V; Almahmoud, K; Burlew, CC; Cahill, A; Campion, EM; Dissanaike, S; Foley, N; Frazee, R; Hartline, C; Jackson, T; Kim, D; Michaels, D; Nelson, P; Olatubosun, O; Pearcy, C; Regner, J; Spence, L; Stewart, C; Todd, SR; Truitt, MS | 1 |
| Antonoff, MB; Atay, SM; Correa, AM; Hofstetter, WL; Mehran, RJ; Rice, DC; Roth, JA; Sepesi, B; Swisher, SG; Vaporciyan, AA; Walsh, G | 1 |
| Backman, JT; Hirvensalo, P; Holmberg, MT; Itkonen, MK; Kärjä, V; Männistö, VT; Neuvonen, M; Neuvonen, PJ; Niemi, M; Paile-Hyvärinen, M; Pihlajamäki, J; Tapaninen, T; Tarkiainen, EK; Tornio, A | 1 |
| Cattabiani, MA; De Palma, R; Guastaroba, P; Marino, M; Menozzi, A; Rasia, M; Solinas, E; Tadonio, I; Vignali, L | 1 |
| Bompelli, N; Deshpande, A; Khardenavis, V; Reddy C, R | 1 |
| Bhatt, DL; Deliargyris, EN; Eisen, A; Gibson, CM; Hamm, CW; Harrington, RA; Mahaffey, KW; Prats, J; Price, MJ; Steg, PG; Stone, GW; White, HD | 1 |
| Abubakar, H; Hassan, AAI; Ibrahim, W; Subahi, A | 1 |
| Amiel, J; Chevallier, D; De Broca, B; Durand, M; Prader, R | 1 |
| Cho, JY; Hong, SJ; Joo, HJ; Kim, KA; Lee, SH; Lim, DS; Park, JH; Park, JY; Yu, CW | 1 |
| Cai, X; Jing, J; Johnston, SC; Li, H; Liu, L; Meng, X; Pan, Y; Wang, D; Wang, Y; Wei, T; Zhao, X | 1 |
| Jin, J; Luo, X; Qian, C; Yang, M; Zuo, Z | 1 |
| Cai, WY; Yang, J; Zeng, P | 1 |
| Lohitnavy, M; Lohitnavy, O; Morasuk, T; Tangamornsuksan, W; Thiansupornpong, P | 1 |
| Dudek, D; Dziewierz, A; Kleczyński, P; Plens, K; Rakowski, T; Siudak, Z | 1 |
| Bonnet, PA; Brenier, C; Ghyselinck, C; Martin, M; Rebiere, H | 1 |
| Alexopoulos, D; Angiolillo, DJ; Aradi, D; Bhatt, DL; Bonello, L; Cuisset, T; De Luca, L; Franchi, F; Gurbel, PA; Hochholzer, W; James, S; Mehran, R; Montalescot, G; Price, MJ; Rollini, F; Schneider, DJ; Sibbing, D; So, DYF; Storey, RF; Tantry, US; Trenk, D; Valgimigli, M; Waksman, R; Wang, TY | 1 |
| Chariyavilaskul, P; Chunsangchan, M; Ketchart, W; Prompila, N; Wittayalertpanya, S | 1 |
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| Bossard, M; Faxon, DP; Fox, KAA; Gao, P; Granger, CB; Jolly, SS; Mehta, SR; Montalescot, G; Natarajan, MK; Niemela, K; Steg, PG; Tanguay, JF; Widimsky, P; Yusuf, S | 1 |
| Athanasiou, A; Damaskos, C; Moris, D; Politou, M; Spartalis, E; Spartalis, M; Tzatzaki, E | 1 |
| Carugo, S; Castini, D; Cazzaniga, S; Centola, M; Ferrante, G; Lucreziotti, S; Persampieri, S; Salerno-Uriarte, D; Sponzilli, C | 1 |
| Li, YH; Wan, YM; Wu, HM; Wu, XN; Xu, Y; Xu, ZY; Yang, JH; Yang, LH | 1 |
| de Man, FHAF; Doggen, CJM; Hartmann, M; Knottnerus, IL; Kok, MM; Linssen, GCM; Louwerenburg, JW; Löwik, MM; Stoel, MG; van der Heijden, LC; van Houwelingen, KG; von Birgelen, C; Zocca, P | 1 |
| Bagai, A; Booker, J; Cantor, WJ; Cheema, AN; Crawford, JJ; Dehghani, P; Goodman, SG; Harenberg, S; Kelly, S; Lavi, S; Lavoie, A; Mehta, SR; Pon, Q; Yang, A; Zimmermann, RH | 1 |
| Gremmel, T; Kopp, CW; Koppensteiner, R; Lang, IM; Lee, S; Panzer, S; Pultar, J; Wadowski, PP; Weikert, C | 1 |
| Guan, Y; Hafiz, MZ; He, S; Li, X; Liu, W; Wu, L; Xiong, J; Yan, B; Yang, J | 1 |
| Byun, JK; Choi, BG; Choi, CU; Choi, SY; Kim, EJ; Kim, JB; Na, JO; Oh, DJ; Park, CG; Rha, SW; Seo, HS | 1 |
| Chantzichristos, V; Giannakis, D; Kalantzi, K; Milionis, H; Papadopoulos, G; Petrou, A; Sofikitis, N; Tselepis, A; Tsoumani, M; Tzimas, P | 1 |
| Chen, J; Ding, N; Li, G; Peng, L; Shao, Y; Wang, Y; Xu, Z; Zhang, C | 1 |
| Cirilli, R; Ferretti, R; Zanitti, L | 1 |
| Abrams-Ogg, ACG; Blois, SL; Saati, S; Wood, RD | 1 |
| Nikiteas, NI; Spartalis, E; Spartalis, M; Tzatzaki, E | 1 |
| Kaiser, C; Wein, B | 1 |
| Angiolillo, DJ; Cattaneo, M; Crimi, G; De Servi, S; Palmerini, T; Piscione, F; Somaschini, A | 1 |
| Denslow, A; Jarosz, J; Nowak, M; Papiernik, D; Porshneva, K; Świtalska, M; Wietrzyk, J | 1 |
| Doan, G; Kaltenbach, T; Lin, D; McQuaid, K; Mou, S; Pham, C; Rouse, RV; Shergill, AK; Soetikno, RM; Somsouk, M | 1 |
| Cognetti, DM; Curry, JM; Luginbuhl, A; Shumrick, C; Tassone, P; Topf, MC; Vo, A | 1 |
| Alexopoulos, D; Lekakis, J; Pappas, C; Sfantou, D | 1 |
| Chen, J; Gao, LJ; Gao, RL; Gao, Z; Qiao, SB; Tang, XF; Xu, B; Xu, JJ; Yang, YJ; Yuan, JQ; Zhang, Y; Zhu, P | 1 |
| Bellesini, M; Donadini, MP; Middeldorp, S; Squizzato, A; Takeda, A | 1 |
| He, X; Hou, J; Li, B; Li, C; Liu, Z; Wu, H; Yang, M; Zhang, Q; Zhao, P; Zhong, M; Zhong, W; Zhong, Z | 1 |
| Chan, R; Ip, P; Kwok, J; Kwong, KM; Lee, SWL; Tam, CC | 1 |
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| Antonijevic, N; Kusic-Tisma, J; Matic, D; Novkovic, M; Radojkovic, D; Rakicevic, L | 1 |
| Armstead, AR; Coshatt, GM; Harada, S; Limdi, NA; Zhou, Y | 1 |
| Baumgartner, I; Berger, JS; Björck, M; Blomster, JI; Fowkes, FGR; Held, P; Hiatt, WR; Jones, WS; Katona, BG; Mahaffey, KW; Norgren, L; Patel, MR; Rockhold, FW; Wojdyla, DM | 1 |
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| Bazan, HA; Berenson, AM; Fort, DG; Hawken, TN; Money, SR; Ramee, SR; Sternbergh, WC | 1 |
| Doran, T; Keles, EC; Kirac, D; Mihmanli, M; Yaman, AE | 1 |
| Fu, H; Lin, J; Mao, D; Mo, Y; Wei, D | 1 |
| Caudle, KE; Gaedigk, A; Gammal, RS; Hulot, JS; Johnson, JA; Kisor, DF; Klein, TE; Lee, CR; Lee, YM; Limdi, NA; Luzum, JA; Roden, DM; Sabatine, MS; Sangkuhl, K; Scott, SA; Shuldiner, AR; Stein, CM | 1 |
| Andreev, D; Baturina, O; Bochkov, P; Fedina, L; Grishina, E; Ivashchenko, D; Mirzaev, K; Ryzhikova, K; Shevchenko, R; Sychev, D | 1 |
| Schäfer, A | 1 |
| Cheng, LC; Chu, PH; Huang, CL; Kuo, FY; Lan, WR; Lee, CH; Lee, WL; Lin, WS; Liu, PY; Lo, PH; Lu, TM; Su, CH; Tsukiyama, S; Wang, YC; Yang, WC; Yin, WH | 1 |
| Chen, H; Chen, L; Gao, X; Hao, G; Liu, J; Yang, F; Zhao, Y | 1 |
| Marston, NA; O'Donoghue, ML | 1 |
| Barry, HC | 1 |
| Friebel, J; Hassanein, A; Jakobs, K; Landmesser, U; Puccini, M; Rauch, C; Rauch, U | 1 |
| Cao, X; Chen, C; Chen, L; Liu, Y; Miao, Y; Niu, J; Sun, Y; Wei, J; Wu, T; Xu, Z | 1 |
| Chou, JW; Derry, K; Huang, WT; Humber, D; Zhang, Y | 1 |
| Ahmed, S; Gul, S; Hamdard, MH; Hussain, A; Janjua, K; Khan, H; Shah, SU; Sheikh, FS; Siraj, S | 1 |
| França, ACW; Macedo, LSDN; Magliano, CADS; Meirelles, I; Piccin Padilla, M; Santos, MDS | 1 |
| Jin, Y; Liu, H; Ma, J; Wang, G; Wang, Y; Wang, Z; Wu, Y; Ye, P; Yin, T; Zou, Y | 1 |
| Circhetta, S; De Luca, R; Grigioni, F; Mangiacapra, F; Melfi, R; Nusca, A; Paolucci, L; Ricottini, E; Ussia, GP; Viscusi, MM | 1 |
| Ben-Yehuda, O; Brodie, BR; Kirtane, AJ; Liu, M; Mehran, R; Metzger, DC; Musikantow, DR; Redfors, B; Rinaldi, MJ; Stone, GW; Stuckey, TD; Weisz, G; Witzenbichler, B | 1 |
| Ahn, CM; Cho, JY; Choi, D; Hong, MK; Hong, SJ; Jang, Y; Kim, BK; Kim, JS; Ko, YG; Lee, SJ; Lee, YJ; Yun, KH | 1 |
| Agewall, S; Hasegawa, K; Komiyama, M | 1 |
| Feng, J; Li, H; Shen, H; Sun, L; Wang, T; Wu, J; Xu, L; Yu, L; Zhang, H; Zhao, T; Zhou, L | 1 |
| de Havenon, A; Kraler, L; Lansberg, MG; Zhou, LW | 1 |
| Harahap, AR; Harris, S; Herqutanto, H; Hidayat, R; Listyaningsih, E; Loho, T; Louisa, M; Nabilah, RA; Rambe, AS; Rasyid, A | 1 |
| Deneer, VHM; Gimbel, ME; Ten Berg, JM; van den Broek, WWA; van Paassen, JG; Vreman, RA | 1 |
| Demchuk, AM; Jahn, B; Menon, BK; Micieli, A; Siebert, U; Singh, N | 1 |
| Cheng, J; Deng, X; Li, H; Ma, Y; Shi, T; Wang, X; Wu, Y; Zhang, Z; Zhu, Q | 1 |
| Li, X; Sun, Y; Tian, WJ; Wang, DL; Wang, L; Wang, RN; Xia, XS | 1 |
| Fujii, S; Fujita, K; Hirai, S; Ishikawa, M; Karakama, J; Miki, K; Nemoto, S; Sumita, K; Yamaoka, H; Yoshimura, M | 1 |
| Di Tommaso, L; Mannacio, L; Mannacio, V | 1 |
| Gong, Y; He, Y; Lai, X; Li, YG; Liu, X; Liu, Y; Sun, H; Yan, X; Zhang, EY; Zhang, L | 1 |
| Fan, X; Jiao, L; Ma, H; Meng, X; Wang, J; Zhao, L | 1 |
| Caminiti, G; Muscoli, S; Perrone, MA; Pradhan, A; Salimei, C; Sethi, R; Tiwari, A | 1 |
| Bath, PM; Leach, M; McDermott, JH; Newman, WG; Sen, D; Smith, CJ | 1 |
| Anderson, MN; Cheves, TA; Gegri, M; McTaggart, R; Sweeney, JD | 1 |
| Chen, L; Li, J; Shi, X; Su, J; Yang, J; Yu, Q; Zhu, K | 1 |
| Dookeeram, D; Giddings, S; Gomes, C; Grimaldos, G; Grimaldos, K; Ishmael, A; Kampradi, L; Peram, L; Ramlackhansingh, A; Raza, S; Richard, S; Sandy, S; Schneider, D; Seecheran, NA; Seecheran, R; Seecheran, V; Sukha, D; Tello-Montoliu, A; Umaharan, P | 1 |
| Kirtane, AJ; Mehran, R | 1 |
| DE Luca, G; Gioscia, R; Kedhi, E; Nardin, M; Rognoni, A; Suryapranata, H; Verdoia, M | 1 |
| Moustafa, B; Testai, FD | 1 |
| Han, K; Huang, X; Ma, M; Sun, T; Yang, S; Zhao, Z; Zhou, Y | 1 |
| Angiolillo, DJ; Galli, M; Ortega-Paz, L | 1 |
| Chang, R; Liu, Y; Wu, J; Ye, Y; Zhang, X; Zhou, W | 1 |
| Cheng, Y; Li, D; Liu, H; Shao, T; Wang, H; Yang, T; Zhang, J; Zhang, T | 1 |
| Bode, C; Diehl, P; Gjermeni, D; Hesselbarth, D; Moser, M; Olivier, CB; Siegel, PM; Szabo, S | 1 |
| Bennett, CL; Godwin, AC; Hoque, S; Taylor, MA | 1 |
| Ahlbrecht, S; Dannenberg, L; Helten, C; Hohlfeld, T; Huhn, R; Kelm, M; M'Pembele, R; Mourikis, P; Naguib, D; Petzold, T; Polzin, A; Trojovsky, K; Zako, S; Zeus, T | 1 |
| Kim, Y; Latz, CA; Pack, N; Weissler, EH | 1 |
| Alarcon, C; Friedman, P; Gong, L; Klein, T; Meltzer, D; Nutescu, EA; O'Brien, T; Perera, MA; Tuck, M; Yang, G | 1 |
| Djordjevic, N | 1 |
| Li, X; Lv, Q; Wang, Z; Xu, S; Yao, Y | 1 |
| Aldica, M; Anchidin, OI; Blendea, D; Moldovan, H; Molnar, A; Nemes, A; Pop, D; Rosianu, SH | 1 |
| Arthur, JM; Arulprakash, N; Corken, A; Dai, J; Davis, O; Hedayati, SS; Jain, N; Mehta, JL; Phadnis, MA; Rahmatallah, Y; Smyth, S; Ware, J | 1 |
| Agbani, EO; Eagles, ME; Eesa, M; Hill, MD; Mitha, AP; Muram, S; Panchendrabose, K; Riva-Cambrin, J; Salam, MSA | 1 |
| Fu, M; Ge, PX; Ji, JZ; Jiang, LP; Mi, QY; Tai, T; Tang, K; Wu, Y; Xie, HG; Zhao, XH; Zhu, T | 1 |
| Gu, Y; Li, W; Liu, J; Mu, S; Peng, Q; Wang, C; Xie, R; Yang, X; Zhang, H; Zhang, L; Zhou, Y; Zhu, Y | 1 |
| Atar, D; Gurvich, ML; Marciniak, TA; Serebruany, VL; Tanguay, JF | 1 |
| Chen, BL; Dai, W; Mo, ZZ; Peng, YY; Tang, J; Wang, G; Yuan, Z; Zhang, W; Zhou, WL | 1 |
| Deguchi, I; Osada, T; Takahashi, S | 1 |
| Jin, H; Liang, Q; Shen, X; Song, J; Sun, G; Yu, Y | 1 |
| Chen, S; Li, M; Li, Y; Pan, H; Qiang, J; Tian, R; Yuan, T; Zhang, Y; Zhao, B; Zhu, H | 1 |
| Ferrante, A; Montalescot, G | 1 |
| Ahn, SG; Chang, K; Cho, JR; Choi, KH; Choi, SH; Gwon, HC; Hahn, JY; Her, AY; Hong, D; Jeong, MH; Jeong, YH; Joo, HJ; Kim, BK; Kim, HS; Kim, MH; Lee, JM; Lee, SH; Lee, SY; Lim, DS; Park, TK; Park, Y; Shin, ES; Song, YB; Suh, JW; Yang, JH | 1 |
| Chen, X; Hu, X; Li, H; Li, M; Ma, Q; Peng, L; Song, P; Tang, J; Zhang, Y; Zhou, G | 1 |
| Manunga, J; Pai, A; Pedersen, C; Skeik, N; Stanberry, L; Sullivan, TM | 1 |
| Davidson, S | 1 |
| Bellomo, T; Boada, AE; Dua, A; Goudot, G; Hall, RP; Jessula, S; Kukreja, N; Lee, I; Majumdar, M; Parmar, G; Suarez Ferreira, SP | 1 |
| Huang, J; Liao, F; Shu, X; Tang, J | 1 |
| Alex, AG; Attumalil, TV; Dave, RG; Geevar, T; George, P; Gowri, SM; Joseph, G; Mony, PK; Nair, SC; Perla, HT; Thomson, VS | 1 |
| Hong, N; Kim, SB; Son, YJ; Yang, HJ | 1 |
| Anyanor, A; Eze, H; Jisieike-Onuigbo, NN; Kalu, AO; Ndulue, CN; Odenigbo, CU; Oguejiofor, F; Okwesa, NJ; Osakwe, N; Ozuemba, BC | 1 |
| Abrams-Ogg, ACG; Blois, SL; Kornya, MR; Wood, RD | 1 |
| Dahlen, JR; Hosokawa, K; Kitagawa, K; Ohnishi, T; Shirai, Y; Yamazaki, M | 1 |
| Ahmad, FS; Anderson, RD; Benziger, CP; Effron, MB; Farrehi, P; Girotra, S; Gupta, K; Harrington, RA; Hernandez, AF; Jain, SK; Jones, WS; Kripalani, S; Marquis-Gravel, G; Muñoz, D; Polonsky, TS; Roe, MT; Rothman, RL; Stebbins, A; Whittle, J; Wruck, L | 1 |
| Algarni, RA; Alshargi, O; Alshehri, S; Alshibani, M; Althagafi, AA | 1 |
1442 review(s) available for ticlopidine and clopidogrel
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Drug Interactions; Heme; Humans; Models, Biological; Pharmacokinetics; Structure-Activity Relationship; Time Factors | 2012 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Novel antithrombotic drugs in development.
Topics: Amino Acid Sequence; Animals; Clinical Trials as Topic; Clopidogrel; Fibrinolytic Agents; Glycoproteins; Molecular Sequence Data; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein C; Thrombomodulin; Thrombosis; Ticlopidine | 1995 |
[Antithrombotic agents and prevention of cerebrovascular accidents].
Topics: Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Clopidogrel; Echocardiography; Humans; Intracranial Embolism and Thrombosis; Platelet Aggregation Inhibitors; Primary Prevention; Ticlopidine | 1996 |
Ticlopidine or clopidogrel as alternatives to aspirin in prevention of ischemic stroke.
Topics: Aspirin; Brain Ischemia; Cerebrovascular Disorders; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1996 |
New thoughts on strategies for modulating platelet function through the inhibition of surface receptors.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Drug Evaluation, Preclinical; Endothelium, Vascular; Humans; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Cell Surface; Signal Transduction; Thrombosis; Ticlopidine; Type C Phospholipases | 1996 |
Clopidogrel.
Topics: Animals; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1997 |
[Post myocardial infarction management].
Topics: Aftercare; Anticholesteremic Agents; Antioxidants; Atorvastatin; Chromans; Clopidogrel; Diet, Fat-Restricted; Heptanoic Acids; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyrroles; Risk Factors; Thiazoles; Thiazolidinediones; Ticlopidine; Troglitazone | 1997 |
[Antithrombotic therapy after cerebral ischemia].
Topics: Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Heparinoids; Humans; Intracranial Embolism and Thrombosis; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 1997 |
[Pharmacology of ticlopidine and clopidogrel in comparison with acetylsalicylic acid].
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Coronary Thrombosis; Death, Sudden, Cardiac; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 1997 |
[Secondary prevention following cerebral ischemia: is monotherapy with acetylsalicylic acid still first choice?].
Topics: Anticoagulants; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 1998 |
Beyond aspirin.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Antiplatelet drugs in secondary prevention of stroke.
Topics: Aged; Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
The antiplatelet effects of ticlopidine and clopidogrel.
Topics: Cardiovascular Diseases; Clopidogrel; Drug Costs; Female; Humans; Male; Neutropenia; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
[Antithrombotic agents in unstable angina. Review of clinical trials].
Topics: Angina, Unstable; Aspirin; Clopidogrel; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 1998 |
The results of CAPRIE, IST and CAST. Clopidogrel vs. Aspirin in Patients at Risk of Ischaemic Events. International Stroke Trial. Chinese Acute Stroke Trial.
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Double-Blind Method; Humans; Ischemia; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 1998 |
Atherosclerosis: a unifying disorder with diverse manifestations.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; United States | 1998 |
Antiplatelet therapy in coronary artery disease: review and update of efficacy studies.
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Disease; Dipyridamole; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Clinical considerations in selecting antiplatelet therapy in cerebrovascular disease.
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Management of peripheral arterial disease.
Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Clopidogrel: secondary prevention of vascular ischaemic events.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 1998 |
Evolution of improved antithrombotic and antiplatelet agents: genesis of the Comparison of Abciximab Complications with Hirulog [and back-Up Abciximab] Events Trial (CACHET).
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Aspirin; Cardiac Catheterization; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Heparin; Hirudin Therapy; Hirudins; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Research Design; Ticlopidine | 1998 |
Antithrombotic therapy in peripheral arterial occlusive disease.
Topics: Angioplasty, Balloon, Coronary; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Endarterectomy, Carotid; Fibrinolytic Agents; Graft Occlusion, Vascular; Humans; Leg; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine; Warfarin | 1998 |
[Clopidogrel].
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Clinical pharmacology of the adenosine diphosphate (ADP) receptor antagonist, clopidogrel.
Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Aspirin; Clopidogrel; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Signal Transduction; Thrombosis; Ticlopidine | 1998 |
Results of the CAPRIE trial: efficacy and safety of clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events.
Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Follow-Up Studies; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Treatment Outcome | 1998 |
Antiplatelet therapy. Aspirin, ticlopidine/clopidogrel, and anti-integrin agents.
Topics: Aspirin; Clopidogrel; Humans; Integrins; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 1998 |
Antiplatelet agents and stroke prevention.
Topics: Aspirin; Atrial Fibrillation; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Antiplatelet drugs in secondary prevention after acute myocardial infarction.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Antiplatelet therapy for secondary stroke prevention.
Topics: Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk Factors; Survival Rate; Ticlopidine | 1999 |
Clopidogrel with aspirin is the optimal antiplatelet regimen for intracoronary stenting.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Therapy, Combination; Hematologic Diseases; Humans; Platelet Aggregation Inhibitors; Premedication; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 1999 |
Low molecular weight heparins in the cardiac catheterization laboratory.
Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Cardiac Catheterization; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Enoxaparin; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Tunica Intima | 1999 |
Aspirin and ticlopidine after routine coronary stenting: the gold standard as of 1999.
Topics: Anemia, Aplastic; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Therapy, Combination; Health Policy; Hematologic Diseases; Hemorrhage; Humans; Multivariate Analysis; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Premedication; Purpura, Thrombotic Thrombocytopenic; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Stents; Ticlopidine; Treatment Outcome | 1999 |
Antiplatelet therapy for treatment of acute coronary syndromes.
Topics: Abciximab; Acetates; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Disease; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Peptides; Platelet Aggregation Inhibitors; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine; Vascular Patency | 1999 |
Management of high-risk subsets in unstable angina.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Atherectomy, Coronary; Calcium Channel Blockers; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Heparin; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Intra-Aortic Balloon Pumping; Nitrates; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 1999 |
[Current therapy for unstable angina pectoris].
Topics: Angina, Unstable; Anti-Bacterial Agents; Anticholesteremic Agents; Anticoagulants; Antithrombins; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Fibrinolytic Agents; Heparin; Hirudin Therapy; Humans; Macrolides; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 1999 |
[Arteriopathy of the lower limbs: toward a global medical care].
Topics: Angiography; Arterial Occlusive Diseases; Arteriosclerosis; Cilostazol; Clinical Trials as Topic; Clopidogrel; Endothelial Growth Factors; Genetic Therapy; Humans; Iloprost; Leg; Lymphokines; Multicenter Studies as Topic; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Protein Isoforms; Randomized Controlled Trials as Topic; Tetrazoles; Ticlopidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasodilator Agents | 1999 |
Clopidogrel: a new antiplatelet agent.
Topics: Arteriosclerosis; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Clopidogrel: the future choice for preventing platelet activation during coronary stenting?
Topics: Clopidogrel; Coronary Disease; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 1999 |
Therapeutic benefit. Aspirin revisited in light of the introduction of clopidogrel.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Decision Making; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 1999 |
Clinical aspects of the use of clopidogrel, a new antiplatelet agent.
Topics: Clopidogrel; Drug Interactions; Humans; Randomized Controlled Trials as Topic; Ticlopidine | 1999 |
Antiplatelet agents and the role of clopidogrel in the prevention of secondary atherosclerotic events.
Topics: Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Bleeding complications in secondary stroke prevention by antiplatelet therapy: a benefit-risk analysis.
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk; Ticlopidine; Treatment Outcome | 1999 |
Antiplatelet therapy in the prevention of ischemic vascular events: literature review and evidence-based guidelines for drug selection.
Topics: Algorithms; Arteriosclerosis; Aspirin; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Critical Pathways; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk; Ticlopidine | 1999 |
Future directions in thrombolysis.
Topics: Clopidogrel; Coronary Disease; Coronary Thrombosis; Cyclooxygenase 2; Enzyme Inhibitors; Fibrinolytic Agents; Forecasting; Humans; Isoenzymes; Membrane Proteins; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prostaglandin-Endoperoxide Synthases; Thrombolytic Therapy; Ticlopidine | 1999 |
Antiplatelet agents in the prevention of cardiovascular morbidity and mortality in older patients with vascular disease.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Diseases | 1999 |
Ticlopidine and clopidogrel.
Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Angina, Unstable; Aspirin; Bone Marrow Diseases; Carbamazepine; Cardiovascular Diseases; Clopidogrel; Combined Modality Therapy; Coronary Disease; Drug Interactions; Hemorrhage; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Phenytoin; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Safety; Stents; Theophylline; Thrombolytic Therapy; Ticlopidine | 1999 |
[Antiplatelet therapy].
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Collagen; Humans; Immunoglobulin Fab Fragments; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thromboembolism; Thrombophilia; Ticlopidine | 1999 |
Use of clopidrogel in coronary stenting: what was the question?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Stents; Ticlopidine; Treatment Outcome | 1999 |
Antiplatelet therapy in interventional cardiology: I. Newer oral antiplatelet agents.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2000 |
Antiplatelet and anticoagulant therapy in the secondary prevention of ischemic heart disease.
Topics: Anticoagulants; Aspirin; Clopidogrel; Coronary Disease; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine; Treatment Outcome | 2000 |
Clopidogrel and [symbol: see text] ticlopidine--improvements on aspirin?
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Contraindications; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 1999 |
Beyond heparin and aspirin: new treatments for unstable angina and non-Q-wave myocardial infarction.
Topics: Angina, Unstable; Antithrombins; Clopidogrel; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Hirudin Therapy; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thromboxane; Recombinant Proteins; Thromboxane-A Synthase; Ticlopidine | 2000 |
Treatment of unstable angina: the role of platelet inhibitors and anticoagulants.
Topics: Abciximab; Angina, Unstable; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Coronary Thrombosis; Endothelium, Vascular; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Tirofiban; Tyrosine | 1999 |
Aspirin, ticlopidine and clopidogrel in and out of the catheterization laboratory.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 1999 |
[Aspirin and cerebral ischemic accidents].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Cerebral Infarction; Clinical Trials as Topic; Clopidogrel; Cyclooxygenase Inhibitors; Dipyridamole; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Phosphodiesterase Inhibitors; Placebos; Platelet Aggregation Inhibitors; Primary Prevention; Recurrence; Risk Factors; Stroke; Ticlopidine; Vasodilator Agents; Warfarin | 2000 |
Thienopyridine derivatives (ticlopidine, clopidogrel) versus aspirin for preventing stroke and other serious vascular events in high vascular risk patients.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2000 |
Thienopyridines or aspirin to prevent stroke and other serious vascular events in patients at high risk of vascular disease? A systematic review of the evidence from randomized trials.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Ticlopidine | 2000 |
Vascular drugs in the new millennium.
Topics: Abciximab; Animals; Anistreplase; Antibodies, Monoclonal; Anticoagulants; Aspirin; Chondroitin Sulfates; Clopidogrel; Dermatan Sulfate; Drug Combinations; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Heparitin Sulfate; Humans; Immunoglobulin Fab Fragments; Intermittent Claudication; Platelet Aggregation Inhibitors; Streptokinase; Ticlopidine; Vascular Diseases; Venous Thrombosis | 2000 |
Antiplatelet agents in cardiology: the choice of therapy.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2000 |
The thienopyridines in coronary artery disease.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 1999 |
Antithrombotic therapy in the cardiac catheterization laboratory: focus on antiplatelet agents.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Cardiac Catheterization; Clopidogrel; Coronary Disease; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2000 |
Clopidogrel: a review of its use in the prevention of atherothrombosis.
Topics: Arteriosclerosis; Clinical Trials as Topic; Clopidogrel; Drug Interactions; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Stents; Thrombosis; Ticlopidine | 2000 |
Clopidogrel and coronary stenting: what is the next question?
Topics: Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2000 |
Optimization of platelet therapy.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Atherectomy, Coronary; Clopidogrel; Coronary Disease; Humans; Immunoglobulin Fab Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Stents; Ticlopidine; Treatment Outcome | 2000 |
Antiplatelet agents for stroke prevention.
Topics: Aspirin; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stroke; Ticlopidine | 2000 |
Prevention of ischaemic stroke--antiplatelets.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2000 |
Update on clinical trials of antiplatelet therapy for cerebrovascular diseases.
Topics: Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2000 |
Antiplatelet agents in stroke prevention. combination therapy: present and future.
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Clopidogrel; Dipyridamole; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Stroke; Ticlopidine | 2000 |
[Therapeutic inhibition of platelets in a acute coronary syndrome and in coronary intervention: mechanisms and clinical results].
Topics: Abciximab; Acute Disease; Adult; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Animals; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Disease; Cyclooxygenase Inhibitors; Humans; Immunoglobulin Fab Fragments; Meta-Analysis as Topic; Mice; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Stents; Syndrome; Ticlopidine | 2000 |
Antiplatelet medications and their indications in preventing and treating coronary thrombosis.
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2000 |
Value of antiplatelet therapy in preventing thrombotic events in generalized vascular disease.
Topics: Arteriosclerosis; Clopidogrel; Eptifibatide; Humans; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Tirofiban; Tyrosine | 2000 |
The future of antiplatelet therapy: optimizing management in patients with acute coronary syndrome.
Topics: Angina, Unstable; Clopidogrel; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2000 |
Optimizing antiplatelet therapy in coronary interventions.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Coronary Disease; Humans; Immunoglobulin Fab Fragments; Myocardial Revascularization; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2000 |
Antithrombotic therapy in cardiac stent patients.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Disease; Humans; Immunoglobulin Fab Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2001 |
Novel platelet inhibitors.
Topics: Arteriosclerosis; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Treatment Outcome | 2001 |
Stroke prevention: antiplatelet and antithrombolytic therapy.
Topics: Anticoagulants; Aspirin; Brain Damage, Chronic; Carotid Stenosis; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Endarterectomy, Carotid; Fibrinolytic Agents; Gastritis; Goals; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Ischemic Attack, Transient; Meta-Analysis as Topic; Multicenter Studies as Topic; Neutropenia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk; Safety; Single-Blind Method; Stroke; Thrombolytic Therapy; Ticlopidine; Treatment Failure; Treatment Outcome | 2000 |
Clopidogrel (Plavix): hematological reactions.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2001 |
Antiplatelet therapy in the elderly. Aspirin, ticlopidine-clopidogrel, and GPIIb/GPIIIa antagonists.
Topics: Aged; Aged, 80 and over; Aspirin; Clinical Trials as Topic; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prognosis; Sensitivity and Specificity; Thromboembolism; Ticlopidine; Treatment Outcome | 2001 |
Benefit of ADP receptor antagonists in atherothrombotic patients: new evidence.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2001 |
New recommendations from the 1999 American College of Cardiology/American Heart Association acute myocardial infarction guidelines.
Topics: Adrenergic beta-Antagonists; Aged; American Heart Association; Angioplasty, Balloon, Coronary; Cardiology; Clopidogrel; Contraindications; Female; Fibrinolytic Agents; Heparin; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Societies, Medical; Stents; Thrombolytic Therapy; Ticlopidine; United States | 2001 |
Regular or "super-aspirins"? A review of thienopyridines or aspirin to prevent stroke.
Topics: Aspirin; Clopidogrel; Drug Combinations; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2001 |
[Acute coronary syndromes: an update. I. Pathogenesis and drug therapy].
Topics: Acute Disease; Administration, Oral; Adrenergic beta-Antagonists; Angina, Unstable; Anticoagulants; Aspirin; Calcium Channel Blockers; Clinical Trials as Topic; Clopidogrel; Electrocardiography; Fibrinolytic Agents; Humans; Multicenter Studies as Topic; Myocardial Infarction; Nitrates; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Syndrome; Terminology as Topic; Ticlopidine; Tirofiban; Tyrosine | 2001 |
Aspirin in patients with coronary artery disease: is it simply irresistible?
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Benzamidines; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Cyclooxygenase Inhibitors; Diabetes Complications; Dipyridamole; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Endothelium, Vascular; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Oximes; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Randomized Controlled Trials as Topic; Stroke; Thrombosis; Thromboxane-A Synthase; Ticlopidine; Vasodilator Agents | 2001 |
The role of adenosine 5'-diphosphate receptor blockade in patients with cardiovascular disease.
Topics: Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticlopidine | 2001 |
The use of antiplatelet agents in acute cardiac care.
Topics: Aspirin; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2001 |
Complications of oral antiplatelet medications.
Topics: Administration, Oral; Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2001 |
Thrombotic thrombocytopenic purpura associated with clopidogrel administration: case report and brief review.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; HIV Infections; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Purpura, Thrombotic Thrombocytopenic; Risk Factors; Ticlopidine | 2001 |
Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome.
Topics: Antibiotics, Antineoplastic; Clopidogrel; Cyclosporine; Hemolytic-Uremic Syndrome; Humans; Immunosuppressive Agents; Mitomycin; Muscle Relaxants, Central; Platelet Aggregation Inhibitors; Quinine; Ticlopidine | 2001 |
Antiplatelet agents for secondary prevention of ischemic stroke.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2001 |
[New drugs].
Topics: Amdinocillin; Carbamates; Clopidogrel; Cyclohexanes; Drug Interactions; Humans; Hypoglycemic Agents; Nateglinide; Patient Selection; Penicillins; Phenylalanine; Piperidines; Platelet Aggregation Inhibitors; Pneumococcal Vaccines; Raloxifene Hydrochloride; Safety; Selective Estrogen Receptor Modulators; Ticlopidine | 2001 |
What can I do to continue walking despite intermittent claudication?
Topics: Aspirin; Cilostazol; Clopidogrel; Humans; Intermittent Claudication; Tetrazoles; Ticlopidine; Vasodilator Agents; Walking | 2001 |
Acute profound thrombocytopenia following angioplasty: the dilemma in the management and a review of the literature.
Topics: Abciximab; Acute Disease; Aged; Antibodies, Monoclonal; Anticoagulants; Catheterization; Clopidogrel; Coronary Restenosis; Diagnosis, Differential; Drug Combinations; Heparin; Humans; Immunoglobulin Fab Fragments; Male; Platelet Aggregation Inhibitors; Stents; Thrombocytopenia; Ticlopidine | 2001 |
Combination therapy with clopidogrel and aspirin: can the CURE results be extrapolated to cerebrovascula patients?
Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2001 |
Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting.
Topics: Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Therapy, Combination; Humans; Odds Ratio; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Registries; Stents; Ticlopidine | 2002 |
New antiplatelet agents: ticlopidine and clopidogrel. Antiplatelet therapy but at what cost?
Topics: Aspirin; Bone Marrow; Clopidogrel; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2001 |
The medicinal chemistry of the P2 receptor family.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Arteriosclerosis; Cloning, Molecular; Clopidogrel; Cystic Fibrosis; Humans; Ophthalmic Solutions; Polyphosphates; Receptors, Purinergic P2; Structure-Activity Relationship; Ticlopidine; Tissue Distribution; Uracil Nucleotides | 2001 |
Rationale for the use of platelet aggregation inhibitors in PAD patients.
Topics: Aspirin; Clopidogrel; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2001 |
Atherothrombosis--the neurologist's point of view.
Topics: Clopidogrel; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk Factors; Stroke; Thrombosis; Ticlopidine; Time Factors | 2001 |
[Antithrombotic treatment protocols in interventional cardiology].
Topics: Aspirin; Clopidogrel; Drug Resistance; Enoxaparin; Fibrinolytic Agents; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2001 |
From CURE to MATCH: ADP receptor antagonists as the treatment of choice for high-risk atherothrombotic patients.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Drug Therapy, Combination; Heparin; Humans; Intracranial Arteriosclerosis; Intracranial Thrombosis; Ischemic Attack, Transient; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Recurrence; Risk Factors; Stroke; Ticlopidine | 2002 |
Persistence of the prothrombotic state after acute coronary syndromes: implications for treatment.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Thrombosis; Heparin, Low-Molecular-Weight; Humans; Myocardial Infarction; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Thrombolytic Therapy; Ticlopidine; Time Factors; Warfarin | 2002 |
The use of antithrombotic drugs in older people.
Topics: Aged; Aspirin; Clopidogrel; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pulmonary Embolism; Secondary Prevention; Stroke; Thromboembolism; Thrombolytic Therapy; Ticlopidine; Venous Thrombosis; Warfarin | 2002 |
Preventing atherothrombotic events in peripheral arterial disease: the use of antiplatelet therapy.
Topics: Algorithms; Arteriosclerosis; Aspirin; Clopidogrel; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2002 |
[Role of clopidogrel in acute coronary syndromes without ST-segment elevation].
Topics: Acute Disease; Administration, Oral; Clopidogrel; Coronary Disease; Electrocardiography; Humans; Infusions, Parenteral; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2002 |
The WRIST series--what have we learnt?
Topics: Aged; Angioplasty, Balloon, Coronary; Brachytherapy; Clopidogrel; Cohort Studies; Coronary Restenosis; Eptifibatide; Female; Follow-Up Studies; Gamma Rays; Humans; Iridium Radioisotopes; Male; Middle Aged; Multicenter Studies as Topic; Peptides; Placebos; Platelet Aggregation Inhibitors; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine; Time Factors; Yttrium Radioisotopes | 2002 |
[Intracoronary radiation therapy in controlled and open clinical trials with afterloading systems and "hot" balloon catheters. Analysis of 6,692 patients].
Topics: Aged; Angioplasty, Balloon, Coronary; Beta Particles; Brachytherapy; Clinical Trials as Topic; Clopidogrel; Coronary Angiography; Coronary Restenosis; Female; Follow-Up Studies; Gamma Rays; Humans; Male; Middle Aged; Placebos; Platelet Aggregation Inhibitors; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Stents; Ticlopidine; Time Factors | 2002 |
Prevention of heart failure.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Antihypertensive Agents; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Diabetes Complications; Disease Progression; Health Behavior; Heart Failure; Humans; Hyperlipidemias; Hypertension; Platelet Aggregation Inhibitors; Prevalence; Renal Insufficiency; Risk Factors; Smoking; Ticlopidine; Ventricular Dysfunction, Left | 2002 |
The role of platelets in peripheral arterial disease: therapeutic implications.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2002 |
[Modern therapy in acute coronary syndrome].
Topics: Angina, Unstable; Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Survival Rate; Ticlopidine | 2002 |
Antithrombotic drugs for prevention of recurrent stroke.
Topics: Adult; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2002 |
The thienopyridines.
Topics: Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Pyridines; Ticlopidine | 2002 |
Antiplatelet treatment in unstable angina: aspirin, clopidogrel, glycoprotein IIb/IIIa antagonist, or all three?
Topics: Administration, Oral; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Costs; Drug Therapy, Combination; Humans; Infusions, Intravenous; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2002 |
Antithrombotic agents: implications in dentistry.
Topics: Anticoagulants; Aspirin; Blood Coagulation Tests; Clopidogrel; Dental Care; Drug Interactions; Embolism; Fibrinolytic Agents; Hemostasis; Heparin; Heparin, Low-Molecular-Weight; Humans; Oral Hemorrhage; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine; Tirofiban; Tyrosine; Venous Thrombosis; Warfarin | 2002 |
Aspirin beyond platelet inhibition.
Topics: Abciximab; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Artery Disease; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2002 |
Role of antiplatelet agents in cardioprotection.
Topics: Arteriosclerosis; Aspirin; Cardiotonic Agents; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; United States | 2002 |
Is CURE a cure for acute coronary syndromes? Statistical versus clinical significance.
Topics: Acute Disease; Angina, Unstable; Clinical Trials as Topic; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk; Secondary Prevention; Ticlopidine | 2002 |
Potential emerging therapeutic strategies to prevent restenosis in the peripheral vasculature.
Topics: Animals; Blood Vessels; Brachytherapy; Cilostazol; Clopidogrel; Constriction, Pathologic; Drug Delivery Systems; Endothelium, Vascular; Genetic Therapy; Heparin, Low-Molecular-Weight; Humans; Plastic Surgery Procedures; Platelet Aggregation Inhibitors; Probucol; Stents; Tetrazoles; Ticlopidine; Vasodilation; Vasodilator Agents | 2002 |
Clopidogrel and acute coronary syndrome.
Topics: Acute Disease; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2002 |
Clopidogrel in interventional cardiology: questions answered and questions remaining.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2002 |
[Antiproliferative coated stents and intracoronary brachytherapy: common traits and differences].
Topics: Brachytherapy; Cell Division; Cilostazol; Clinical Trials as Topic; Clopidogrel; Coated Materials, Biocompatible; Coronary Angiography; Coronary Restenosis; Humans; Platelet Aggregation; Tetrazoles; Ticlopidine; Treatment Outcome | 2002 |
Heparin dose during percutaneous coronary intervention: how low dare we go?
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Heparin; Heparin, Low-Molecular-Weight; Humans; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thrombin; Ticlopidine | 2002 |
State of the art--a journey through the world of antithrombotic therapy.
Topics: Ambulatory Care; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Coronary Disease; Fibrinolytic Agents; Heart Failure; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Orthopedic Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Guidelines as Topic; Recurrence; Respiratory Insufficiency; Thromboembolism; Thrombolytic Therapy; Thrombophlebitis; Thrombosis; Ticlopidine | 2002 |
A benefit-risk assessment of agents used in the secondary prevention of stroke.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Antihypertensive Agents; Aspirin; Clinical Trials as Topic; Clopidogrel; Coumarins; Dipyridamole; Humans; Hypertension; Hypoglycemic Agents; Insulin; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Smoking Cessation; Stroke; Ticlopidine; Warfarin | 2002 |
Combination antiplatelet therapy: implications for pharmacists.
Topics: Adult; Aspirin; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Eptifibatide; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Patient Compliance; Peptides; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2002 |
Spontaneous multivessel coronary artery dissection in a long-distance runner successfully treated with oral antiplatelet therapy.
Topics: Adult; Aortic Dissection; Aspirin; Clopidogrel; Coronary Aneurysm; Exercise; Female; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Radiography; Ticlopidine | 2002 |
[Secondary and primary prevention of coronary heart disease: platelet aggregation inhibitors and anticoagulants].
Topics: Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Interactions; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Ticlopidine | 2002 |
Preventing thrombosis: update of first-line therapy in the management of non-ST segment elevation acute coronary syndromes.
Topics: Acute Disease; Algorithms; Clopidogrel; Coronary Disease; Coronary Thrombosis; Enoxaparin; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recurrence; Risk Factors; Ticlopidine | 2002 |
Management of patients with intermittent claudication.
Topics: Aspirin; Blood Vessel Prosthesis; Cilostazol; Clopidogrel; Exercise Therapy; Humans; Intermittent Claudication; Medical History Taking; Pentoxifylline; Physical Examination; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Vasodilator Agents | 2002 |
Clinical implications of CURE and PCI-CURE in patients with the acute coronary syndrome without persistent ST-elevation.
Topics: Acute Disease; Anticoagulants; Aspirin; Clopidogrel; Coronary Disease; Electrocardiography; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Syndrome; Ticlopidine | 2002 |
Platelets: is aspirin sufficient or must we know how to pronounce abciximab?
Topics: Abciximab; Antibodies, Monoclonal; Arteriosclerosis; Aspirin; Blood Platelets; Clopidogrel; Endarterectomy, Carotid; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Ticlopidine; Tirofiban; Tyrosine | 2002 |
The thienopyridine derivatives (platelet adenosine diphosphate receptor antagonists), pharmacology and clinical developments.
Topics: Anesthesia; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2003 |
[Clopidogrel. Actions, pharmacokinetics, clinical studies].
Topics: Blood Platelets; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Thromboembolism; Thrombosis; Ticlopidine | 2002 |
Utility of platelet adp receptor antagonism in the emergency department: a review.
Topics: Aspirin; California; Clopidogrel; Coronary Disease; Critical Care; Drug Utilization; Emergency Service, Hospital; Female; Humans; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prognosis; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Risk Assessment; Severity of Illness Index; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome | 2003 |
[Treatment strategy of unstable angina and non-ST-segment elevation myocardial infarction].
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Angiography; Electrocardiography; Humans; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Ticlopidine; Time Factors | 2002 |
[Endovascular brachytherapy to prevent restenosis after angioplasty].
Topics: Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Arterial Occlusive Diseases; Aspirin; Brachytherapy; Clinical Trials as Topic; Clopidogrel; Combined Modality Therapy; Coronary Restenosis; Follow-Up Studies; Humans; Retreatment; Stents; Ticlopidine | 2003 |
2002 update to the ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: implications for emergency department practice.
Topics: American Heart Association; Angina, Unstable; Anticoagulants; Cardiology; Child; Clopidogrel; Electrocardiography; Emergency Service, Hospital; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Societies, Medical; Ticlopidine; United States | 2003 |
Sirolimus-eluting stents: a review of experimental and clinical findings.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Animals; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Restenosis; Disease Models, Animal; Drug Delivery Systems; Follow-Up Studies; Humans; Immunosuppressive Agents; Injections, Intramuscular; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Rats; Sirolimus; Stents; Swine; Thrombosis; Ticlopidine; Time Factors; Ultrasonography, Interventional | 2002 |
Short- and long-term oral antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention.
Topics: Acute Disease; Administration, Oral; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Humans; Myocardial Infarction; Outcome Assessment, Health Care; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Platelet activation in patients with congestive heart failure: do we have enough evidence to consider clopidogrel?
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Heart Failure; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticlopidine; Treatment Outcome | 2003 |
Preventing stroke in patients with atrial fibrillation: current treatments and new concepts.
Topics: Aspirin; Atrial Appendage; Atrial Fibrillation; Azetidines; Benzylamines; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Prodrugs; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Ticlopidine; Treatment Outcome; Warfarin | 2003 |
Appropriate antiplatelet and antithrombotic therapy in patients with acute coronary syndromes: recent updates to the ACC/AHA guidelines.
Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Fibrinolytic Agents; Heparin; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Survival Rate; Ticlopidine | 2002 |
Evidence with antiplatelet therapy and ADP-receptor antagonists.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Stroke; Thrombosis; Ticlopidine | 2003 |
[Platelet inhibitors: old and new].
Topics: Abciximab; Antibodies, Monoclonal; Arteriosclerosis; Aspirin; Clopidogrel; Coronary Disease; Dipyridamole; Drug Monitoring; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Membrane Proteins; Patient Selection; Peptides; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombosis; Thromboxanes; Ticlopidine | 2002 |
Aspirin and clopidogrel in patients with ACS undergoing PCI: CURE and PCI-CURE.
Topics: Adult; Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Assessment; Severity of Illness Index; Survival Analysis; Ticlopidine; Treatment Outcome | 2003 |
Clopidogrel in acute coronary syndromes (unstable angina and non-Q-wave myocardial infarction).
Topics: Angina, Unstable; Clinical Trials as Topic; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Aspirin and clopidogrel in acute coronary syndromes: therapeutic insights from the CURE study.
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Syndrome; Ticlopidine | 2003 |
Management of anticoagulants before and after endoscopy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Clopidogrel; Endoscopy, Gastrointestinal; Gastrointestinal Diseases; Heparin; Heparin, Low-Molecular-Weight; Humans; Plasma; Postoperative Care; Preoperative Care; Ticlopidine; Vitamin K; Warfarin | 2003 |
[Clopidogrel: background information and use in clinical practice].
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Stroke; Thrombosis; Ticlopidine | 2003 |
Clopidogrel and thrombotic thrombocytopenic purpura: no clear case for causality.
Topics: Causality; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Risk Assessment; Ticlopidine | 2003 |
What is the role for improved long-term antiplatelet therapy after percutaneous coronary intervention?
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Brachytherapy; Clopidogrel; Coronary Disease; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Endothelium, Vascular; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thrombosis; Ticlopidine; Warfarin | 2003 |
Emergency management of hemorrhagic complications in the era of glycoprotein IIb/IIIa receptor antagonists, clopidogrel, low molecular weight heparin, and third-generation fibrinolytic agents.
Topics: Acute Disease; Angina, Unstable; Clopidogrel; Emergency Medical Services; Fibrinolytic Agents; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Syndrome; Ticlopidine | 2003 |
[Update cardiology 2001/2002-part II. From unstable coronary syndrome to terminal heart failure].
Topics: Abciximab; Acute Disease; Adrenergic beta-Antagonists; Angina, Unstable; Antibodies, Monoclonal; Anticholesteremic Agents; Arrhythmias, Cardiac; Aspirin; Atorvastatin; Clopidogrel; Defibrillators, Implantable; Double-Blind Method; Fibrinolytic Agents; Heart Failure; Heart Septal Defects, Atrial; Heart Transplantation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin Fab Fragments; Myocardial Infarction; Placebos; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrroles; Quality of Life; Randomized Controlled Trials as Topic; Regeneration; Risk Factors; Syndrome; Ticlopidine; Time Factors; Tirofiban; Tyrosine | 2003 |
The role of platelets and platelet inhibition in acute myocardial infarction.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Fibrinolytic Agents; Humans; Membrane Glycoproteins; Myocardial Infarction; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Ticlopidine; Tissue Plasminogen Activator | 2003 |
Contemporary use of antiplatelet therapies in percutaneous coronary interventions.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Disease; Hirudins; Humans; Immunoglobulin Fab Fragments; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Stents; Ticlopidine | 2003 |
Clinical pharmacokinetics of antiplatelet agents used in the secondary prevention of stroke.
Topics: Aspirin; Aspirin, Dipyridamole Drug Combination; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Combinations; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2003 |
Current management of non-ST-segment-elevation acute coronary syndrome: reconciling the results of randomized controlled trials.
Topics: Anticoagulants; Clopidogrel; Coronary Disease; Echocardiography, Stress; Heparin, Low-Molecular-Weight; Humans; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Syndrome; Ticlopidine | 2003 |
Platelet ADP inhibitors in ischemic heart disease.
Topics: Clinical Trials as Topic; Clopidogrel; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Combined antiplatelet therapy in atrial fibrillation: review of the literature and future avenues.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Combinations; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2003 |
Review of antithrombotic agents used for acute coronary syndromes in renal patients.
Topics: Acute Disease; Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Fibrinolytic Agents; Hemorrhagic Disorders; Humans; Kidney Diseases; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombolytic Therapy; Ticlopidine | 2003 |
Angina (unstable).
Topics: Angina, Unstable; Aspirin; Clopidogrel; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Warfarin | 2003 |
Antiplatelet treatment in stable coronary artery disease.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Ticlopidine | 2003 |
[Antiplatelet drugs in prevention and treatment of coronary heart disease: aspirin is obligatory, quite sufficient, and safe].
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Resistance; Drug Tolerance; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
[Antiplatelet drugs in prevention of complications of arteriosclerotic diseases: it is necessary to move beyond aspirin].
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Death, Sudden, Cardiac; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2003 |
The role of clopidogrel in the management of acute coronary syndromes.
Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Drug Interactions; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Treatment of unstable angina pectoris/non-ST-segment elevation myocardial infarction in elderly patients.
Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Electrocardiography; Humans; Hypolipidemic Agents; Myocardial Infarction; Oxygen Inhalation Therapy; Ticlopidine | 2003 |
[Treatment of acute stroke -- an overview].
Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Aspirin; Brain Edema; Case-Control Studies; Cerebral Infarction; Clinical Trials, Phase IV as Topic; Clopidogrel; Contraindications; Double-Blind Method; Fibrinolytic Agents; Heparin; Humans; Hypertension; Immunoglobulin Fab Fragments; Intracranial Pressure; Intubation, Intratracheal; Ischemic Attack, Transient; Meta-Analysis as Topic; Middle Aged; Multicenter Studies as Topic; Placebos; Plasminogen Activators; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Randomized Controlled Trials as Topic; Respiration, Artificial; Stroke; Thrombolytic Therapy; Ticlopidine; Time Factors; Tissue Plasminogen Activator; Tomography, X-Ray Computed; Ultrasonography | 2003 |
[Carotid stenosis: diagnosis, patient selection, therapy].
Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Aspirin; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Fibrinolytic Agents; Forecasting; Humans; Life Expectancy; Magnetic Resonance Angiography; Patient Selection; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Stents; Stroke; Ticlopidine; Tomography, X-Ray Computed; Ultrasonography, Doppler, Duplex | 2003 |
[Clopidogrel before and after percutaneous coronary intervention: the PCI-CURE and CREDO studies do not support long-term therapy. Shorter treatment saves millions].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug Costs; Humans; Platelet Aggregation Inhibitors; Postoperative Care; Premedication; Randomized Controlled Trials as Topic; Ticlopidine; Time Factors | 2003 |
Aspirin and stroke prevention.
Topics: Aspirin; Clopidogrel; Dipyridamole; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Failure; Treatment Outcome | 2003 |
Role of antiplatelet drugs in the prevention of cardiovascular events.
Topics: Aspirin; Benzamidines; Clopidogrel; Coronary Artery Disease; Humans; Myocardial Infarction; Oximes; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Stroke; Ticlopidine; Treatment Outcome | 2003 |
[Platelet aggregation disorders].
Topics: Blood Platelet Disorders; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Ticlopidine | 2003 |
[Should we use clopidogrel instead of ticlopidine in elective coronary angioplasty?].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Thrombosis; Ticlopidine | 2003 |
Safety and efficacy evaluation of clopidogrel compared to ticlopidine after stent implantation: an updated meta-analysis.
Topics: Adult; Aged; Clopidogrel; Combined Modality Therapy; Confidence Intervals; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Odds Ratio; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Stents; Survival Analysis; Ticlopidine; Treatment Outcome; Vascular Patency | 2003 |
Clopidogrel: interactions with the P2Y12 receptor and clinical relevance.
Topics: Amino Acid Sequence; Animals; Blood Platelets; Clopidogrel; Humans; Molecular Sequence Data; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2003 |
Aggrenox((R)) versus other pharmacotherapy in preventing recurrent stroke.
Topics: Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Cost-Benefit Analysis; Delayed-Action Preparations; Dipyridamole; Drug Combinations; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Stroke; Ticlopidine | 2004 |
Integrating antithrombin and antiplatelet therapies with early invasive management for non-ST-segment elevation acute coronary syndromes.
Topics: Algorithms; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Eptifibatide; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Integrin beta3; Myocardial Ischemia; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Thrombolytic Therapy; Ticlopidine | 2004 |
Clopidogrel: potential in the prevention of cardiovascular events in patients with acute coronary syndromes.
Topics: Angioplasty, Balloon; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine | 2001 |
Recent clinical trial results with antiplatelet therapy: implications in stroke prevention.
Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Risk Reduction Behavior; Stroke; Ticlopidine | 2004 |
Highlights of latest advances in antithrombotics.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thromboembolism; Ticlopidine | 2004 |
Trials of newer approaches to anticoagulation in atrial fibrillation.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Azetidines; Benzylamines; Clopidogrel; Humans; International Normalized Ratio; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Thrombin; Ticlopidine; Warfarin | 2004 |
[Role of glycoprotein IIb/IIIa inhibitors in the management of acute coronary syndromes].
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Myocardial Revascularization; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2003 |
The role of warfarin and aspirin in secondary prevention of stroke.
Topics: Anticoagulants; Aspirin; Clopidogrel; Heart Septal Defects, Atrial; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome; Warfarin | 2004 |
[Interactions of statins with antithrombotic drugs].
Topics: Animals; Anticholesteremic Agents; Aspirin; Atorvastatin; Cardiovascular Diseases; Clopidogrel; Controlled Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Fibrinolytic Agents; Follow-Up Studies; Hemostasis; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Pravastatin; Primary Prevention; Pyrroles; Rats; Ticlopidine; Time Factors | 2004 |
Epidurals and clopidogrel in peripheral vascular surgery.
Topics: Analgesia, Epidural; Clopidogrel; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Surgical Procedures | 2004 |
Percutaneous coronary intervention in diabetic patients with non-ST-segment elevation acute coronary syndromes.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Coronary Restenosis; Diabetic Angiopathies; Drug Implants; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Syndrome; Thiazolidinediones; Ticlopidine | 2004 |
Antiplatelet agents in atherothrombotic diseases.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Dipyridamole; Humans; Ischemia; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine | 2004 |
Prevention of coronary heart disease with aspirin and clopidogrel: efficacy, safety, costs and cost-effectiveness.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2004 |
Clopidogrel's role in the management of atherosclerotic disease: a focus on acute coronary syndromes.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Stents; Ticlopidine; Treatment Outcome; Vascular Diseases | 2003 |
Antiplatelet treatment for secondary prevention of acute ischemic stroke and transient ischemic attacks: mechanisms, choices and possible emerging patterns of use.
Topics: Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Dipyridamole; Drug Combinations; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2003 |
The use of clopidogrel in patients with coronary artery disease.
Topics: Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Atrial fibrillation: should we target platelets or the coagulation pathway?
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Stroke; Thrombolytic Therapy; Ticlopidine; Venous Thrombosis; Warfarin | 2003 |
Peripheral arterial disease. A systemic disease extending beyond the affected extremity.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Clopidogrel; Exercise; Geriatrics; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Smoking Cessation; Ticlopidine | 2004 |
Hypothesis: atorvastatin has pleiotropic effects that translate into early clinical benefits on cardiovascular disease.
Topics: Anticholesteremic Agents; Atorvastatin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Heptanoic Acids; Humans; Lipid Peroxidation; Platelet Aggregation Inhibitors; Pyrroles; Randomized Controlled Trials as Topic; Ticlopidine | 2004 |
[The value of platelet inhibitors in the secondary prophylaxis of stroke -- a review].
Topics: Aspirin; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 2004 |
[EBM of cerebral infarction: message from mega-studies].
Topics: Anticoagulants; Aspirin; Azetidines; Benzylamines; Cerebral Infarction; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Secondary Prevention; Ticlopidine; Warfarin | 2003 |
Clopidogrel in the management of cerebrovascular events.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Drug Costs; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Thrombosis; Ticlopidine | 2004 |
Platelet ADP receptor antagonists: ticlopidine and clopidogrel.
Topics: Arteriosclerosis; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridines; Ticlopidine; Treatment Outcome | 2004 |
[Treatment of ischemic heart disease with the platelet aggregation inhibitor clopidogrel].
Topics: Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Therapy, Combination; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Stroke; Ticlopidine | 2004 |
Acute coronary syndromes in women: is treatment different? Should it be?
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Female; Fibrinolytic Agents; Humans; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Stents; Syndrome; Thrombin; Ticlopidine; Women's Health | 2004 |
Clopidogrel: how good is it and how does it work?
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Endothelium, Vascular; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine; Treatment Outcome | 2004 |
Antiplatelet agents.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Design; Drug Resistance; Drug Therapy, Combination; Humans; Meta-Analysis as Topic; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Ticlopidine | 2004 |
Increased mortality after coronary stenting in patients treated with clopidogrel without loading dose. Evidence from a meta-analysis.
Topics: Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2004 |
Antithrombotic drugs in vascular medicine: a historical perspective.
Topics: Administration, Oral; Anticoagulants; Aspirin; Blood Platelets; Clopidogrel; Endothelium, Vascular; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine | 2003 |
P2Y12, a new platelet ADP receptor, target of clopidogrel.
Topics: Adenosine Diphosphate; Angina, Unstable; Animals; Blood Platelets; Clopidogrel; Down-Regulation; Humans; Membrane Proteins; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stroke; Ticlopidine | 2003 |
Combined antithrombotic therapy for acute coronary syndrome.
Topics: Administration, Oral; Angina, Unstable; Anticoagulants; Aspirin; Clopidogrel; Coronary Thrombosis; Dipyridamole; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2003 |
Does the use of statins compromise the effectiveness of platelet inhibition by clopidogrel?
Topics: Clopidogrel; Drug Antagonism; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation; Ticlopidine; Treatment Outcome | 2004 |
Antithrombotic treatment of NSTEMI/UAP. The interaction with PCI.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2004 |
[Acute coronary syndromes without ST segment elevation].
Topics: Acute Disease; Adrenergic beta-Antagonists; Analgesics, Opioid; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Calcium Channel Blockers; Clopidogrel; Coronary Disease; Electrocardiography; Enoxaparin; Humans; Morphine; Myocardial Revascularization; Oxygen Inhalation Therapy; Patient Selection; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Ticlopidine; Time Factors | 2004 |
Antiplatelet agents and anticoagulants for hypertension.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Humans; Hypertension; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thromboembolism; Ticlopidine; Warfarin | 2004 |
CD40 ligand: a novel target in the fight against cardiovascular disease.
Topics: Cardiovascular Agents; Cardiovascular Diseases; CD40 Ligand; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thiazolidinediones; Ticlopidine | 2004 |
Relationship between activated clotting time and ischemic or hemorrhagic complications: analysis of 4 recent randomized clinical trials of percutaneous coronary intervention.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Blood Coagulation Tests; Clopidogrel; Comorbidity; Coronary Restenosis; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Hemorrhage; Heparin; Hirudins; Humans; Immunoglobulin Fab Fragments; Incidence; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Ischemia; Peptide Fragments; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recombinant Proteins; Retrospective Studies; Stents; Thrombophilia; Ticlopidine; Tirofiban; Tyrosine | 2004 |
[Platelet Adhesion Assay (PADA), a new quantitative test for assessment of platelet function and therapeutic drug monitoring of GPIIb/IIIa and ADP receptor antagonists].
Topics: Blood Specimen Collection; Clopidogrel; Humans; Monitoring, Physiologic; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Ticlopidine | 2004 |
Role of clopidogrel in unstable angina and non-ST-segment elevation myocardial infarction: from literature and guidelines to practice.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Hemorrhage; Humans; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine | 2004 |
Antiplatelet therapy in peripheral arterial disease.
Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Dipyridamole; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2004 |
Antithrombotic therapy for coronary artery disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
Topics: Antithrombins; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Coronary Thrombosis; Electrocardiography; Evidence-Based Medicine; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Myocardial Infarction; Randomized Controlled Trials as Topic; Risk Assessment; Ticlopidine | 2004 |
Thrombolysis and adjunctive therapy in acute myocardial infarction: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
Topics: Aspirin; Clopidogrel; Contraindications; Drug Therapy, Combination; Electrocardiography; Evidence-Based Medicine; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Infusions, Intravenous; Injections, Subcutaneous; Myocardial Infarction; Randomized Controlled Trials as Topic; Risk Assessment; Secondary Prevention; Thrombolytic Therapy; Ticlopidine | 2004 |
Antithrombotic therapy during percutaneous coronary intervention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Contraindications; Coronary Restenosis; Coronary Stenosis; Drug Therapy, Combination; Evidence-Based Medicine; Fibrinolytic Agents; Heparin; Hirudins; Humans; Immunoglobulin Fab Fragments; Peptide Fragments; Practice Guidelines as Topic; Pyridines; Recombinant Proteins; Risk Assessment; Stents; Ticlopidine | 2004 |
Antithrombotic therapy in patients with saphenous vein and internal mammary artery bypass grafts: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
Topics: Aspirin; Clopidogrel; Contraindications; Coronary Artery Bypass; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Evidence-Based Medicine; Fibrinolytic Agents; Graft Occlusion, Vascular; Humans; Internal Mammary-Coronary Artery Anastomosis; Myocardial Infarction; Randomized Controlled Trials as Topic; Risk Assessment; Ticlopidine; Veins | 2004 |
Antithrombotic therapy in peripheral arterial occlusive disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
Topics: Arterial Occlusive Diseases; Aspirin; Cilostazol; Clopidogrel; Contraindications; Evidence-Based Medicine; Extremities; Fibrinolytic Agents; Heparin; Humans; Intermittent Claudication; Ischemia; Randomized Controlled Trials as Topic; Risk Assessment; Tetrazoles; Thromboembolism; Ticlopidine; Vitamin K | 2004 |
Aspirin and clopidogrel: efficacy, safety, and the issue of drug resistance.
Topics: Aspirin; Clopidogrel; Drug Resistance; Humans; Ticlopidine; Treatment Failure; Treatment Outcome; Venous Thrombosis | 2004 |
Clinical effectiveness and cost-effectiveness of clopidogrel and modified-release dipyridamole in the secondary prevention of occlusive vascular events: a systematic review and economic evaluation.
Topics: Aspirin; Clopidogrel; Cost-Benefit Analysis; Delayed-Action Preparations; Diarrhea; Dipyridamole; Drug Costs; Drug Eruptions; Dyspepsia; Evidence-Based Medicine; Hemorrhage; Humans; Ischemia; Models, Econometric; Nausea; Platelet Aggregation Inhibitors; Research Design; Risk Factors; Ticlopidine; Treatment Outcome; Vascular Diseases; Vomiting | 2004 |
Clopidogrel used in combination with aspirin compared with aspirin alone in the treatment of non-ST-segment-elevation acute coronary syndromes: a systematic review and economic evaluation.
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Drug Therapy, Combination; Electrocardiography; Humans; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2004 |
The results of MATCH: light or heat?
Topics: Aspirin; Clopidogrel; Controlled Clinical Trials as Topic; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Stroke; Ticlopidine | 2004 |
Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease.
Topics: Administration, Oral; Angina Pectoris; Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Coronary Artery Disease; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Stroke; Thrombosis; Ticlopidine | 2004 |
Comparative benefits of clopidogrel and aspirin in high-risk patient populations: lessons from the CAPRIE and CURE studies.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Comorbidity; Diabetes Mellitus; Humans; Hypercholesterolemia; Myocardial Ischemia; Platelet Aggregation Inhibitors; Recurrence; Risk; Ticlopidine | 2004 |
Platelet function testing in cardiovascular diseases.
Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Case Management; Clopidogrel; Drug Resistance; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine; Treatment Outcome | 2004 |
[Cardiovascular risk in diabetes--diagnostic and therapeutic aspects].
Topics: Abciximab; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Antibodies, Monoclonal; Aspirin; Blood Glucose; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Diabetes Complications; Diabetes Mellitus; Follow-Up Studies; Glucose Tolerance Test; Humans; Hypolipidemic Agents; Immunoglobulin Fab Fragments; Insulin; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Primary Prevention; Risk; Risk Factors; Stents; Ticlopidine; Time Factors | 2004 |
Prevention of cardiovascular events in diabetes.
Topics: Angioplasty, Balloon; Antihypertensive Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Bypass; Diabetic Angiopathies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Smoking Cessation; Ticlopidine | 2003 |
Risk:benefit assessment of old medicines.
Topics: Antihypertensive Agents; Antipsychotic Agents; Bias; Clinical Trials as Topic; Clopidogrel; Diuretics; Drug Approval; Humans; Pharmaceutical Preparations; Risk Assessment; Ticlopidine; Treatment Outcome | 2004 |
G13-mediated signaling as a potential target for antiplatelet drugs.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Forecasting; Germany; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Signal Transduction; Ticlopidine | 2004 |
Preparing for the post-warfarin generation of antithrombotics.
Topics: Atrial Fibrillation; Azetidines; Benzimidazoles; Benzylamines; Clopidogrel; Fibrinolytic Agents; Fondaparinux; Humans; Oligosaccharides; Platelet Aggregation Inhibitors; Polysaccharides; Prodrugs; Pyridines; Stroke; Ticlopidine | 2004 |
New possibilities in anticoagulant management of atrial fibrillation.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Azetidines; Benzylamines; Clopidogrel; Humans; Oligosaccharides; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Warfarin | 2004 |
Stroke: advances in therapy.
Topics: Aspirin; Carotid Stenosis; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Endarterectomy, Carotid; Fibrinolytic Agents; Humans; Myocardial Infarction; Plasminogen Activators; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Stroke; Ticlopidine; Treatment Outcome | 2005 |
Controversies of oral antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention.
Topics: Administration, Oral; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Drug Synergism; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2004 |
Cilostazol, clopidogrel or ticlopidine to prevent sub-acute stent thrombosis: a meta-analysis of randomized trials.
Topics: Anticoagulants; Aspirin; Cilostazol; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Humans; Odds Ratio; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Tetrazoles; Ticlopidine; Warfarin | 2004 |
Secondary prevention of recurrent stroke.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Diabetes Complications; Endarterectomy; Endarterectomy, Carotid; Fibrinolytic Agents; Homocysteine; Humans; Platelet Aggregation Inhibitors; Risk; Risk Factors; Secondary Prevention; Stents; Stroke; Ticlopidine; Vitamin B Complex | 2005 |
[Aspirin: recent advances in cardiovascular prevention].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Primary Prevention; Ticlopidine | 2004 |
Stroke prevention. MATCHing therapy to the patient with TIA.
Topics: Aspirin; Clopidogrel; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Stroke; Ticlopidine | 2005 |
Existence of a clinically relevant interaction between clopidogrel and HMG-CoA reductase inhibitors? Re-evaluating the evidence.
Topics: Atorvastatin; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Meta-Analysis as Topic; Multicenter Studies as Topic; Prodrugs; Pyrroles; Ticlopidine | 2005 |
Combination antiplatelet agents in ischemic cerebrovascular disease.
Topics: Aspirin; Brain Ischemia; Cardiovascular Diseases; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2005 |
[Antithrombotic therapy after myocardial infarction: arguments for the use of acetylsalicylic acid and coumarin derivatives].
Topics: Anticoagulants; Aspirin; Clopidogrel; Coumarins; Death, Sudden, Cardiac; Fibrinolytic Agents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Ticlopidine | 2005 |
Percutaneous coronary intervention versus coronary artery bypass grafting in diabetic patients.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Diabetic Angiopathies; Humans; Hyperplasia; Insulin Resistance; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Retreatment; Stents; Ticlopidine; Tunica Intima | 2005 |
[Antithrombotic therapy of acute coronary syndromes].
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Thrombolytic Therapy; Ticlopidine | 2005 |
[Clopidogrel in the prevention of stroke].
Topics: Clinical Trials as Topic; Clopidogrel; Humans; Injections, Intravenous; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stroke; Thromboembolism; Ticlopidine; Treatment Outcome | 2004 |
Adverse effects and drug interactions of antithrombotic agents used in prevention of ischaemic stroke.
Topics: Anticoagulants; Aspirin; Clopidogrel; Dipyridamole; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Salicylates; Stroke; Ticlopidine; Warfarin | 2005 |
The top 12 advances in vascular medicine.
Topics: Angiotensin-Converting Enzyme Inhibitors; Cilostazol; Clopidogrel; Factor V; Heparin, Low-Molecular-Weight; Hot Temperature; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metabolic Syndrome; Mutation; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Platelet Aggregation Inhibitors; Purines; Sildenafil Citrate; Sulfones; Tetrazoles; Thrombin; Ticlopidine; Vascular Diseases; Vascular Surgical Procedures | 2004 |
What is the risk of stent thrombosis associated with the use of paclitaxel-eluting stents for percutaneous coronary intervention?: a meta-analysis.
Topics: Aged; Angioplasty, Balloon, Coronary; Antineoplastic Agents, Phytogenic; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coated Materials, Biocompatible; Coronary Artery Disease; Coronary Thrombosis; Female; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2005 |
Optimal antithrombotic treatment for percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Blood Coagulation; Clinical Trials as Topic; Clopidogrel; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Stents; Thrombin; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
Efficacy and costs of secondary prevention with antiplatelets after ischaemic stroke.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Health Care Costs; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2005 |
High-dose clopidogrel loading in percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Humans; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
[The inter-individual variability of the response to clopidogrel].
Topics: Cell Adhesion Molecules; Clopidogrel; Flow Cytometry; Humans; Intestinal Absorption; Liver; Membrane Proteins; Microfilament Proteins; Molecular Structure; Phosphoproteins; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2005 |
P2Y receptor antagonists in thrombosis.
Topics: Adenosine Monophosphate; Animals; Clopidogrel; Humans; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Thrombosis; Ticlopidine | 2005 |
Optimal duration of antiplatelet therapy in recipients of coronary drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2005 |
Adding aspirin to clopidogrel after TIA and ischemic stroke: benefits do not match risks.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Drug Synergism; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Risk Assessment; Secondary Prevention; Stroke; Thromboembolism; Ticlopidine | 2005 |
The benefits of abciximab questioned in percutaneous coronary interventions following pretreatment with high-dose clopidogrel.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Immunoglobulin Fab Fragments; Ticlopidine | 2005 |
Resistance to clopidogrel: a review of the evidence.
Topics: Adenosine Diphosphate; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Resistance; Humans; Individuality; Membrane Proteins; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Up-Regulation | 2005 |
Platelet aggregation and adenosine diphosphate/adenosine triphosphate receptors: a historical perspective.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Calcium; Calcium Signaling; Clopidogrel; Cyclic AMP; Drug Resistance; Hemorrhagic Disorders; Hemostasis; Humans; Mice; Mice, Knockout; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Second Messenger Systems; Thrombosis; Ticlopidine | 2005 |
The P2 receptors in platelet function.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Blood Vessels; Cell Shape; Clopidogrel; Cytoplasmic Granules; Fibrinolytic Agents; Humans; Ion Transport; Membrane Proteins; Models, Biological; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor Cross-Talk; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Signal Transduction; Stress, Mechanical; Thrombosis; Ticlopidine | 2005 |
The platelet P2 receptors in thrombosis.
Topics: Adenosine Diphosphate; Animals; Blood Vessels; Clinical Trials as Topic; Clopidogrel; Fibrinolytic Agents; Hemorrhagic Disorders; Humans; Membrane Proteins; Mice; Mice, Knockout; Platelet Aggregation Inhibitors; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2005 |
Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis.
Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Cohort Studies; Double-Blind Method; Drug Resistance; Fibrinolytic Agents; Forecasting; Humans; Membrane Proteins; Meta-Analysis as Topic; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridines; Randomized Controlled Trials as Topic; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombophilia; Thrombosis; Ticlopidine | 2005 |
Pharmacology of CS-747 (prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity.
Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Biotransformation; Clinical Trials, Phase I as Topic; Clopidogrel; Collagen; Drug Evaluation, Preclinical; Drug Synergism; Fibrinolytic Agents; Hemostasis; Humans; Male; Membrane Proteins; Molecular Structure; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Thrombin; Thrombosis; Ticlopidine | 2005 |
The value of clopidogrel versus aspirin in reducing atherothrombotic events: the CAPRIE study.
Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Cost-Benefit Analysis; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Ticlopidine | 2004 |
The value of clopidogrel in addition to standard therapy in reducing atherothrombotic events.
Topics: Angioplasty, Balloon, Coronary; Arterial Occlusive Diseases; Aspirin; Benchmarking; Clopidogrel; Drug Therapy, Combination; Humans; Ticlopidine | 2004 |
Issues in the management of antiplatelet therapy in patients undergoing surgical revascularization. A roundtable discussion.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Coronary Stenosis; Female; Humans; Male; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prognosis; Radiography; Risk Assessment; Stents; Survival Rate; Ticlopidine; Treatment Outcome | 2005 |
[Antithrombotic therapy during percutaneous coronary interventions].
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Fibrinolytic Agents; Heparin; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
[Oral antithrombotic therapy in primary and secondary prevention].
Topics: Animals; Aspirin; Clopidogrel; Fibrinolytic Agents; Humans; Primary Prevention; Secondary Prevention; Thrombosis; Ticlopidine | 2005 |
Platelet inhibition in percutaneous coronary interventions.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Premedication; Ticlopidine | 2005 |
Clopidogrel for the secondary prevention of stroke.
Topics: Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine | 2005 |
Clopidogrel in acute coronary syndrome: when, how much, how long?
Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Germany; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Syndrome; Ticlopidine; Treatment Outcome | 2005 |
[Mechanism and drug treatment of atherothrombosis].
Topics: Anticoagulants; Arteriosclerosis; Aspirin; C-Reactive Protein; CD40 Antigens; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombolytic Therapy; Thrombosis; Ticlopidine | 2005 |
Avoiding central nervous system bleeding during antithrombotic therapy: recent data and ideas.
Topics: Administration, Oral; Age Factors; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Blood Pressure; Brain Ischemia; Cerebral Hemorrhage; Clinical Trials as Topic; Clopidogrel; Female; Fibrinolytic Agents; Humans; International Normalized Ratio; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Warfarin | 2005 |
[Advances in adjunctive pharmacological therapy for percutaneous coronary interventions].
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Cardiac Catheterization; Clopidogrel; Coronary Restenosis; Factor X; Fibrinolytic Agents; Follow-Up Studies; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Immunosuppressive Agents; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Risk Factors; Sirolimus; Stents; Thrombolytic Therapy; Thrombosis; Ticlopidine; Time Factors | 2005 |
Aspirin and clopidogrel: a sweeping combination in cardiology.
Topics: Aspirin; Cardiology; Cardiovascular Diseases; Clopidogrel; Humans; Ticlopidine | 2005 |
Resistance to antiplatelet therapy.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Drug Tolerance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2005 |
Female-specific aspects in the pharmacotherapy of chronic cardiovascular diseases.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Cardiovascular Agents; Cardiovascular Diseases; Chronic Disease; Clopidogrel; Digitalis Glycosides; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Sex Factors; Ticlopidine; Women's Health | 2005 |
Meta-analysis of trials comparing oral anticoagulation and aspirin versus dual antiplatelet therapy after coronary stenting. Clues for the management of patients with an indication for long-term anticoagulation undergoing coronary stenting.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Stenosis; Drug Therapy, Combination; Follow-Up Studies; Humans; Long-Term Care; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine; Treatment Outcome | 2005 |
Balancing the benefit and risk of oral antiplatelet agents in coronary artery bypass surgery.
Topics: Administration, Oral; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Assessment; Ticlopidine | 2005 |
CLARITY about the use of clopidogrel in patients with acute coronary syndromes and myocardial infarction.
Topics: Acute Disease; Clopidogrel; Coronary Disease; Humans; Multicenter Studies as Topic; Myocardial Infarction; Randomized Controlled Trials as Topic; Syndrome; Ticlopidine | 2005 |
Therapeutic approaches in arterial thrombosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Disease Progression; Fibrinolytic Agents; Humans; Mice; Models, Biological; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Risk; Signal Transduction; Thrombosis; Ticlopidine; Time Factors | 2005 |
Determinants of the interindividual variability in response to antiplatelet drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clopidogrel; Drug Interactions; Drug Resistance; Humans; Models, Biological; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
Clopidogrel in non-ST segment elevation acute coronary syndromes: an overview of the submission by the British Cardiac Society and the Royal College of Physicians of London to the National Institute for Clinical Excellence, and beyond.
Topics: Acute Disease; Clopidogrel; Coronary Disease; Electrocardiography; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2005 |
[Variable extent of platelet responsiveness to clopidogrel inhibition: "clopidogrel resistance"?].
Topics: Angioplasty, Balloon; Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Thrombosis; Ticlopidine | 2005 |
Antiplatelet agents in patients undergoing percutaneous coronary intervention: how many and how much?
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clinical Trials as Topic; Clopidogrel; Eptifibatide; Hirudins; Humans; Immunoglobulin Fab Fragments; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine; Tirofiban; Tyrosine | 2005 |
Antiplatelet therapy in anticoagulated patients requiring coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thromboembolism; Ticlopidine; Warfarin | 2005 |
Review of antiplatelet therapy in secondary prevention of cerebrovascular events: a need for direct comparisons between antiplatelet agents.
Topics: Aspirin; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Recurrence; Salicylates; Stroke; Ticlopidine | 2005 |
[Triplex antithrombotic therapy after coronary-stent implantation (that is absent from recommendation)].
Topics: Aspirin; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Coronary Vessels; Coumarins; Drug Therapy, Combination; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Secondary Prevention; Stents; Ticlopidine | 2005 |
[The new antithrombotic agents].
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Azetidines; Benzylamines; Clopidogrel; Fibrinolytic Agents; Glycine; Hirudins; Humans; Injections, Subcutaneous; Platelet Aggregation Inhibitors; Polysaccharides; Prodrugs; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine; Time Factors; Venous Thrombosis | 2005 |
[Preventing cerebrovascular accidents during atrial fibrillation].
Topics: Administration, Oral; Age Factors; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Atrial Fibrillation; Azetidines; Benzylamines; Clopidogrel; Drug Therapy, Combination; Electric Countershock; Humans; Hypolipidemic Agents; Incidence; Injections, Subcutaneous; Middle Aged; Oligosaccharides; Placebos; Platelet Aggregation Inhibitors; Prevalence; Prodrugs; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Stroke; Ticlopidine; Warfarin | 2005 |
Effect on platelet function of cilostazol, clopidogrel, and aspirin, each alone or in combination.
Topics: Aspirin; Bleeding Time; Blood Platelets; Cilostazol; Clopidogrel; Drug Therapy, Combination; Humans; Intermittent Claudication; Platelet Aggregation; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Treatment Outcome | 2005 |
[Prevention of periprocedural myocardial damage in patients undergoing percutaneous coronary intervention].
Topics: Actuarial Analysis; Adenosine; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Atorvastatin; Biomarkers; Clopidogrel; Creatine Kinase, MB Form; Electrocardiography; Embolism; Female; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Placebos; Platelet Aggregation Inhibitors; Prospective Studies; Pyrroles; Randomized Controlled Trials as Topic; Risk Factors; Stents; Ticlopidine; Time Factors; Vasodilator Agents | 2005 |
[Current concepts of the antiplatelet and anticoagulant treatment in the prevention of stroke].
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Evidence-Based Medicine; Fibrinolytic Agents; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Recurrence; Stroke; Ticlopidine; Warfarin | 2005 |
Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: where we are now?
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Esomeprazole; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2006 |
Clopidogrel in acute coronary heart disease.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2005 |
Aspirin and clopidogrel resistance: an emerging clinical entity.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Clopidogrel use in coronary artery disease.
Topics: Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist.
Topics: Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2006 |
Best evidence topic report. Clopidogrel plus aspirin or aspirin alone in unstable angina.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something?
Topics: Aspirin; Clopidogrel; Depressive Disorder; Drug Interactions; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Selective Serotonin Reuptake Inhibitors; Ticlopidine | 2006 |
[Haemostasis. Aspirin and clopidogrel platelet resistances].
Topics: Aspirin; Clopidogrel; Drug Resistance; Hemostasis; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Extensive mobile thrombus of the internal carotid artery: a case report, treatment options, and a review of the literature.
Topics: Anticoagulants; Carotid Artery Thrombosis; Carotid Artery, Internal; Carotid Stenosis; Cerebral Angiography; Clopidogrel; Endarterectomy, Carotid; Heparin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Warfarin | 2005 |
[PCI: state of the art].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Coronary Restenosis; Humans; Japan; Platelet Aggregation Inhibitors; Prognosis; Stents; Thrombosis; Ticlopidine | 2006 |
Combination of clopidogrel and statins: a hypothetical interaction or therapeutic dilemma?
Topics: Cardiovascular Diseases; Clopidogrel; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Emerging drugs in peripheral arterial disease.
Topics: Administration, Oral; Anticoagulants; Arterial Occlusive Diseases; Arteries; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Intermittent Claudication; Ischemic Attack, Transient; Myocardial Infarction; Pentoxifylline; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine; Tissue Plasminogen Activator; Vasodilator Agents | 2006 |
[Cardiological (pharmaco)therapy and dental practice].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Thrombosis; Defibrillators, Implantable; Heart Valve Prosthesis; Humans; Oral Surgical Procedures; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Ticlopidine | 2006 |
Does clopidogrel affect outcome after coronary artery bypass grafting? A meta-analysis.
Topics: Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Humans; Length of Stay; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2006 |
Gastrointestinal complications of dual antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Duodenal Ulcer; Endoscopy, Digestive System; Gastrointestinal Diseases; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
[Secondary prevention of acute coronary syndromes: are we following correctly the guidelines?].
Topics: Acute Disease; Adrenergic beta-Antagonists; Algorithms; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Chest Pain; Clinical Trials as Topic; Clopidogrel; Cost-Benefit Analysis; Diagnosis, Differential; Electrocardiography; Evidence-Based Medicine; Fibrinolytic Agents; Forecasting; Guideline Adherence; Humans; Hypolipidemic Agents; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prognosis; Risk Assessment; Syndrome; Ticlopidine | 2006 |
Is clopidogrel cardiovascular medicine's double-edged sword?
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Diseases | 2006 |
Aspirin and clopidogrel resistance.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Resistance, Multiple; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Clopidogrel resistance: implications for coronary stenting.
Topics: Animals; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Stents; Ticlopidine | 2006 |
Thienopyridines in percutaneous coronary interventions: standard procedures and high risk subsets.
Topics: Angioplasty, Balloon, Coronary; Biocompatible Materials; Brachytherapy; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Humans; Metals; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2006 |
[Adding aspirin to clopidogrel in secondary prevention of ischemic stroke: no significant benefits. Results of the Match study].
Topics: Aspirin; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Follow-Up Studies; Hemorrhage; Hospitalization; Humans; Ischemic Attack, Transient; Multicenter Studies as Topic; Myocardial Infarction; Patient Selection; Placebos; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Ticlopidine; Time Factors | 2006 |
Angina (unstable).
Topics: Angina, Unstable; Aspirin; Cardiac Catheterization; Clopidogrel; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Warfarin | 2005 |
Masterclass series in peripheral arterial disease. Antiplatelet therapy for peripheral arterial disease and claudication.
Topics: Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Humans; Intermittent Claudication; Lower Extremity; Meta-Analysis as Topic; Peripheral Vascular Diseases; Phthalic Acids; Platelet Aggregation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
[Dual antithrombotic therapy after implantation of coronary stents].
Topics: Aspirin; Clopidogrel; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Synergism; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2006 |
Clopidogrel resistance: myth or reality?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2006 |
Aspirin resistance: does it exist and is it an important clinical problem?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Resistance; Humans; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2006 |
Percutaneous coronary intervention in a patient with von Willebrand's disease presenting with an acute coronary syndrome.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Angiography; Coronary Disease; Epistaxis; Heparin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Syndrome; Ticlopidine; von Willebrand Diseases | 2006 |
Clopidogrel in the treatment of ischaemic heart disease.
Topics: Adolescent; Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
Antiplatelet therapy in populations at high risk of atherothrombosis.
Topics: Arteriosclerosis; Aspirin; Chemoprevention; Clopidogrel; Drug Therapy, Combination; Embolism, Cholesterol; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thromboembolism; Ticlopidine | 2006 |
MATCH results: implications for the internist.
Topics: Aspirin; Atherosclerosis; Clopidogrel; Controlled Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Europe; Hemorrhage; Humans; Ischemic Attack, Transient; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Thrombosis; Ticlopidine; Treatment Failure; United States | 2006 |
[Atheromatosis of the thoracic aorta and risk of stroke].
Topics: Anticoagulants; Aorta, Thoracic; Aortic Diseases; Aspirin; Atherosclerosis; Clopidogrel; Controlled Clinical Trials as Topic; Echocardiography, Transesophageal; Fibrinolytic Agents; Follow-Up Studies; Humans; Hypolipidemic Agents; Meta-Analysis as Topic; Odds Ratio; Platelet Aggregation Inhibitors; Prognosis; Recurrence; Risk Factors; Stroke; Ticlopidine; Time Factors; Warfarin | 2006 |
[Clopidogrel resistance: a critical problem in the drug eluting stents era].
Topics: Clopidogrel; Drug Resistance; Drug-Eluting Stents; Humans; Ticlopidine | 2006 |
Multiple coronary thrombosis and stent implantation to the subtotally occluded right renal artery in a patient with essential thrombocytosis: a case report with review.
Topics: Angina, Unstable; Angioplasty; Clopidogrel; Coronary Thrombosis; Female; Humans; Hypertension; Middle Aged; Platelet Aggregation Inhibitors; Renal Artery Obstruction; Thrombocythemia, Essential; Thrombosis; Ticlopidine | 2006 |
Prevention of vascular events in patients with cerebrovascular disease: efficacy and appropriate duration of antiplatelet therapy.
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2006 |
Clopidogrel: a pharmacoeconomic review of its use in patients with non-ST elevation acute coronary syndromes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Economics, Pharmaceutical; Humans; Markov Chains; Platelet Aggregation Inhibitors; Prescription Fees; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
Drug insight: Clopidogrel nonresponsiveness.
Topics: Clopidogrel; Coronary Thrombosis; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2006 |
Clopidogrel treatment surrounding percutaneous coronary intervention: when should it be started and stopped?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2006 |
Antiplatelet resistance with aspirin and clopidogrel: is it real and does it matter?
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
Aortic arch atheroma and the risk of stroke.
Topics: Aorta, Thoracic; Aspirin; Atherosclerosis; Clopidogrel; History, 18th Century; Humans; Risk Factors; Stroke; Ticlopidine | 2006 |
Clinico-histopathological characteristics of clopidogrel-induced hepatic injury: case report and review of literature.
Topics: Aged, 80 and over; Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Concurrent use of clopidogrel (Plavix) and atorvastatin (Lipitor) is contraindicated.
Topics: Atorvastatin; Biotransformation; Clopidogrel; Contraindications; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Antagonism; Drug Therapy, Combination; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2006 |
The year in non-ST-segment elevation acute coronary syndromes.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Atorvastatin; Biomarkers; Clopidogrel; Coronary Vessels; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Pravastatin; Prognosis; Pyrroles; Risk Assessment; Stents; Syndrome; Thrombolytic Therapy; Ticlopidine | 2006 |
Clopidogrel pharmacogenetics: promising steps towards patient care?
Topics: Clopidogrel; Humans; Patient Care; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Clopidogrel in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2006 |
Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials.
Topics: Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
[Resistance to acetylsalicylic acid and clopidogrel: current status].
Topics: Aspirin; Clopidogrel; Drug Monitoring; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Diseases | 2006 |
Secondary prevention of ischaemic cardiac events.
Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Antihypertensive Agents; Aspirin; Clopidogrel; Coronary Artery Bypass; Diet; Drug Therapy, Combination; Estrogen Replacement Therapy; Exercise; Female; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Ischemia; Platelet Aggregation Inhibitors; Smoking Cessation; Ticlopidine | 2006 |
Prevention of cardiovascular events in diabetes.
Topics: Angioplasty, Balloon; Antihypertensive Agents; Aspirin; Bezafibrate; Cardiovascular Diseases; Clopidogrel; Diabetic Angiopathies; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Smoking Cessation; Ticlopidine | 2006 |
Does a coxib-associated thrombotic risk limit the clinical use of the compounds as analgesic, antiinflammatory drugs? Arguments against.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 2 Inhibitors; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Patient Selection; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Assessment; Thrombosis; Ticlopidine | 2006 |
Possible mechanisms of drug-induced aspirin and clopidogrel resistance.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Resistance; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Aspirin and clopidogrel resistance: consideration and management.
Topics: Adenosine; Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Restenosis; Drug Resistance; Humans; Membrane Proteins; Myocardial Ischemia; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticagrelor; Ticlopidine | 2006 |
Debate of adjunctive pharmacology for percutaneous coronary intervention: anticoagulation and clopidogrel are not (always) enough.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Clinical Trials as Topic; Clopidogrel; Combined Modality Therapy; Humans; Intraoperative Complications; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Ticlopidine | 2006 |
Debate of adjunctive pharmacology for percutaneous coronary intervention: thrombin inhibitors and clopidogrel are enough.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Clopidogrel; Combined Modality Therapy; Coronary Disease; Heparin; Hirudins; Humans; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Recombinant Proteins; Ticlopidine | 2006 |
Current developments in anti-platelet therapy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cerebral Infarction; Clopidogrel; Drug Resistance; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2006 |
Narrative review: reperfusion strategies for ST-segment elevation myocardial infarction.
Topics: Aged; Algorithms; Clopidogrel; Contraindications; Drug Therapy, Combination; Electrocardiography; Female; Fibrinolytic Agents; Humans; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Time Factors | 2006 |
The safety and efficacy of aspirin and clopidogrel as a combination treatment in patients with coronary heart disease.
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
[Are the NSAIDs able to compromising the cardio-preventive efficacy of aspirin?].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Cyclooxygenase Inhibitors; Drug Interactions; Follow-Up Studies; Humans; Ibuprofen; MEDLINE; Middle Aged; Multivariate Analysis; Naproxen; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk; Thromboxane B2; Ticlopidine; Time Factors | 2006 |
Clinical applications of antiplatelet therapy.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Cyclooxygenase Inhibitors; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Pyridines; Ticlopidine | 2006 |
[Platelet-function inhibitors in the secondary prevention of ischemic stroke].
Topics: Aged; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Secondary Prevention; Stroke; Ticlopidine | 2006 |
Aspirin resistance or variable response or both?
Topics: Aspirin; Clopidogrel; Drug Resistance; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
Clopidogrel response variability, resistance, or both?
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Resistance; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Research Design; Ticlopidine | 2006 |
Prasugrel.
Topics: Adenosine Diphosphate; Animals; Aspirin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase III as Topic; Clopidogrel; Collagen; Coronary Disease; Drug Evaluation, Preclinical; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Drugs, Investigational; Humans; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2006 |
[Antithrombotic treatment of acute coronary syndromes without ST-segment elevation].
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Clopidogrel; Eptifibatide; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Syndrome; Ticlopidine; Tirofiban; Tyrosine | 2006 |
[Pathogenesis and therapy of the acute coronary syndrome: differentiated advantage of glycoprotein IIb/IIIa receptor antagonists for high-risk patients].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Coronary Thrombosis; Diabetes Complications; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Renal Insufficiency; Risk Factors; Syndrome; Ticlopidine; Tirofiban; Troponin; Tyrosine | 2006 |
Clopidogrel resistance?
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Humans; Membrane Proteins; Models, Biological; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2007 |
Drug insight: antithrombotic therapy after percutaneous coronary intervention in patients with an indication for anticoagulation.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Heart Valve Prosthesis Implantation; Heparin; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Practice Guidelines as Topic; Risk Factors; Stents; Thrombosis; Ticlopidine; Venous Thrombosis; Warfarin | 2006 |
Evolving management of ST-segment elevation myocardial infarction: update on recent data.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Fibrinolytic Agents; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Societies, Medical; Thrombolytic Therapy; Ticlopidine; United States | 2006 |
Identification of and management approaches for the high-risk patient.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine | 2006 |
[Acute myocardial infarction: what is new?].
Topics: Acute Disease; Algorithms; Angioplasty, Balloon, Coronary; Anticoagulants; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2005 |
Platelet P2 receptors: old and new targets for antithrombotic drugs.
Topics: Adenosine; Adenosine Monophosphate; Angina, Unstable; Animals; Blood Platelets; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Interactions; Fibrinolytic Agents; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2X; Syndrome; Thiophenes; Ticagrelor; Ticlopidine | 2007 |
Clopidogrel bisulfate: in ST-segment elevation myocardial infarction.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Stroke and the statistics of the aspirin/clopidogrel secondary prevention trials.
Topics: Aspirin; Clinical Protocols; Clinical Trials as Topic; Clopidogrel; Data Interpretation, Statistical; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Reproducibility of Results; Stroke; Ticlopidine; Treatment Outcome | 2007 |
Evolving perspectives on clopidogrel in the treatment of ischemic stroke.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Research Design; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2006 |
The relationship of platelet reactivity to the occurrence of post-stenting ischemic events: emergence of a new cardiovascular risk factor.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Combined Modality Therapy; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Myocardial Infarction; Myocardial Ischemia; Patient Selection; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2006 |
Impact of chronic kidney disease and diabetes on percutaneous coronary intervention outcomes.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Diabetes Complications; Drug-Eluting Stents; Glucose; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2006 |
Accelerating time to reperfusion in acute myocardial infarction: prehospital and emergency department strategies, systems of care, and pharmacologic interventions.
Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Blood Platelets; Cardiovascular Agents; Clopidogrel; Community Health Services; Critical Pathways; Emergency Medical Services; Emergency Service, Hospital; Fibrinolytic Agents; Health Services Accessibility; Heparin; Humans; Myocardial Infarction; Patient Care Team; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Program Development; Ticlopidine; Time Factors; Treatment Outcome; Triage; United States | 2006 |
Measuring antiplatelet drug effects in the laboratory.
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Humans; Laboratories; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2007 |
[Antiplatelet drugs and intraoperative hemorrhage].
Topics: Algorithms; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Humans; Intraoperative Period; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Ticlopidine | 2006 |
Clinical use of clopidogrel in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 2007 |
Platelet inhibitors in non-ST-segment elevation acute coronary syndromes and percutaneous coronary intervention: glycoprotein IIb/IIIa inhibitors, clopidogrel, or both?
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Drug Administration Schedule; Drug Therapy, Combination; Guideline Adherence; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Registries; Research Design; Risk Factors; Syndrome; Ticlopidine | 2006 |
Clinical update on the therapeutic use of clopidogrel: treatment of acute ST-segment elevation myocardial infarction (STEMI).
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Coronary Artery Bypass; Drug Resistance; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine; Treatment Outcome | 2006 |
Understanding and minimizing late thrombosis of drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Drug Delivery Systems; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thromboembolism; Ticlopidine; Time Factors | 2007 |
Thienopyridines in cardiovascular disease: focus on clopidogrel resistance.
Topics: Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Design; Drug Resistance; Drugs, Investigational; Humans; Membrane Proteins; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2007 |
Variable response to clopidogrel in patients with coronary artery disease.
Topics: Clopidogrel; Coronary Artery Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2007 |
Oral antiplatelet therapy for percutaneous coronary revascularization.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Disease; Coronary Thrombosis; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Ticlopidine | 2007 |
Clopidogrel: a review of its use in the prevention of thrombosis.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 2007 |
Current management of transient ischemic attack.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Prognosis; Stents; Stroke; Ticlopidine | 2007 |
[Brain nerve symptoms due to thrombotic microangiopathy].
Topics: ADAM Proteins; ADAMTS13 Protein; Adult; Aged; Aged, 80 and over; Cerebrovascular Disorders; Clopidogrel; Female; Hemolytic-Uremic Syndrome; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine; von Willebrand Factor | 2007 |
Role of clopidogrel in managing atherothrombotic cardiovascular disease.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Variable response to antiplatelet therapy: what does it mean to clinicians?
Topics: Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Failure; Treatment Outcome | 2007 |
Contemporary issues in clopidogrel therapy: new evidence shaping clinical practice.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Electrocardiography; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Ticlopidine; Time Factors | 2007 |
Benefits of clopidogrel in patients undergoing coronary stenting significantly depend on loading dose: evidence from a meta-regression.
Topics: Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Regression Analysis; Stents; Ticlopidine | 2007 |
Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer?
Topics: Aspirin; Atherosclerosis; Cilostazol; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Dipyridamole; Disease Susceptibility; Drug Interactions; Drug Therapy, Combination; Dyslipidemias; Hemorrhage; Humans; Ischemic Attack, Transient; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome; Vasodilator Agents | 2007 |
[Coronary stents, dual antiplatelet therapy and peri-operative problems].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2007 |
[The best of interventional cardiology in 2006].
Topics: Angioplasty, Balloon, Coronary; Cardiology; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Coronary Restenosis; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
Antiplatelet therapy in the treatment of atherothrombotic disease: considering the evidence.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Comorbidity; Drug Therapy, Combination; Evidence-Based Medicine; Female; Humans; Male; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Ticlopidine | 2007 |
[Stents in interventional cardiology].
Topics: Aged; Angioplasty, Balloon, Coronary; Anti-Bacterial Agents; Anti-Inflammatory Agents; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Diabetes Complications; Drug Delivery Systems; Drug Therapy, Combination; Fibrinolytic Agents; Follow-Up Studies; Humans; Immunosuppressive Agents; Middle Aged; Platelet Aggregation Inhibitors; Prednisolone; Randomized Controlled Trials as Topic; Risk Factors; Sirolimus; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives.
Topics: Blood Platelets; Clopidogrel; Forecasting; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2007 |
Significance of aspirin and clopidogrel resistance in patients undergoing percutaneous coronary interventions.
Topics: Angioplasty, Balloon, Coronary; Animals; Aspirin; Blood Platelets; Clopidogrel; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2007 |
Strategies for primary and secondary stroke prevention.
Topics: Antihypertensive Agents; Clopidogrel; Humans; Losartan; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Stroke; Ticlopidine | 2006 |
Use of clopidogrel in coronary artery disease.
Topics: Clopidogrel; Coronary Disease; Electrocardiography; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2007 |
Variable platelet response to aspirin and clopidogrel in atherothrombotic disease.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Biomarkers; Biotransformation; Blood Coagulation Tests; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Thromboxane A2; Thromboxane B2; Ticlopidine; Treatment Failure | 2007 |
The cost of new therapies in cardiovascular care. Time for hope or despair for developing countries.
Topics: Cardiovascular Diseases; Clopidogrel; Developing Countries; Heart Diseases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
[Clopidogrel].
Topics: Cerebral Infarction; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Clinical aspects of platelet inhibitors and thrombus formation.
Topics: Aspirin; Atherosclerosis; Blood Platelets; Cardiovascular Diseases; Cilostazol; Clopidogrel; Dipyridamole; Drug Resistance; Humans; Pentanoic Acids; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Pyridines; Receptor, PAR-1; Stents; Tetrazoles; Thrombosis; Thromboxanes; Ticlopidine | 2007 |
Clopidogrel resistance--the cardiologist's perspective.
Topics: Blood Platelets; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Pharmacoeconomic analysis of clopidogrel in secondary prevention of coronary artery disease.
Topics: Clopidogrel; Coronary Artery Disease; Cost-Benefit Analysis; Economics, Pharmaceutical; Humans; Ticlopidine; United States | 2007 |
Antiplatelet therapy for atherothrombotic disease: an update for the primary care physician.
Topics: Anticoagulants; Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Primary Health Care; Recurrence; Risk Assessment; Stroke; Syndrome; Thrombosis; Ticlopidine | 2007 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Does clopidogrel increase morbidity and mortality after minor head injury.
Topics: Aged; Clopidogrel; Craniocerebral Trauma; Emergency Medicine; Evidence-Based Medicine; Female; Hematoma; Hematoma, Subdural; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Radiography; Ticlopidine | 2007 |
[Very late intrastent thrombosis--at 27 months!].
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Fatal Outcome; Flurbiprofen; Follow-Up Studies; Hernia, Inguinal; Humans; Laparoscopy; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine | 2007 |
[Dual platelet aggregation inhibition in coronary artery stent implantation--what is evidence-based?].
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Coronary Vessels; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stents; Ticlopidine; Time Factors | 2007 |
The role of clopidogrel in the management of ischemic heart disease.
Topics: Aspirin; Clopidogrel; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2007 |
Adjusted indirect meta-analysis of aspirin plus warfarin at international normalized ratios 2 to 3 versus aspirin plus clopidogrel after acute coronary syndromes.
Topics: Anticoagulants; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; International Normalized Ratio; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Assessment; Syndrome; Ticlopidine; Warfarin | 2007 |
[Cardiology 2007].
Topics: Angioplasty, Balloon, Coronary; Cardiopulmonary Resuscitation; Cholesterol; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Coronary Restenosis; Heart Failure; Heart Massage; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
Contemporary use of clopidogrel in patients with coronary artery disease.
Topics: Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2007 |
Should EDTA chelation therapy be used instead of long-term clopidogrel plus aspirin to treat patients at risk from drug-eluting stents?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Chelating Agents; Clopidogrel; Drug Implants; Edetic Acid; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2007 |
The role of clopidogrel in revascularized and nonrevascularized patients with acute coronary syndromes.
Topics: Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Cost-Benefit Analysis; Guideline Adherence; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2007 |
Clopidogrel resistance.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Ticlopidine; Treatment Failure | 2007 |
Optimizing platelet P2Y12 inhibition for patients undergoing PCI.
Topics: Adenosine; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Humans; Membrane Proteins; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2007 |
Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease.
Topics: Angina, Unstable; Aspirin; Atherosclerosis; Biomarkers; Blood Platelets; Clopidogrel; Humans; Inflammation; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Stroke; Thrombosis; Ticlopidine | 2007 |
Antithrombotic treatment in the prevention of ischemic stroke.
Topics: Anticoagulants; Blood Coagulation; Brain Ischemia; Clopidogrel; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Secondary Prevention; Stroke; Thrombin; Ticlopidine; Treatment Outcome | 2007 |
Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2007 |
Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Prevalence; Stents; Ticlopidine | 2007 |
Perioperative use of anti-platelet drugs.
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Elective Surgical Procedures; Hemorrhage; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Does clopidogrel rather than aspirin plus a proton-pump inhibitor reduce the frequency of gastrointestinal complications after cardiac surgery?
Topics: Aspirin; Cardiac Surgical Procedures; Clopidogrel; Drug Therapy, Combination; Evidence-Based Medicine; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Platelet Aggregation Inhibitors; Postoperative Complications; Proton Pump Inhibitors; Ticlopidine | 2007 |
Pro: continuation of aspirin/clopidogrel for cardiac surgery.
Topics: Aspirin; Cardiac Surgical Procedures; Clopidogrel; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Prognosis; Thrombosis; Ticlopidine | 2007 |
Con: continuation of aspirin/clopidogrel for cardiac surgery.
Topics: Aspirin; Cardiac Surgical Procedures; Clopidogrel; Drug Therapy, Combination; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Prognosis; Thrombosis; Ticlopidine | 2007 |
Incremental effect of clopidogrel on important outcomes in patients with cardiovascular disease: a meta-analysis of randomized trials.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Assessment; Stroke; Ticlopidine | 2007 |
Clopidogrel: an updated and comprehensive review.
Topics: Angioplasty, Balloon, Coronary; Animals; Aspirin; Clopidogrel; Drug Approval; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; United States; United States Food and Drug Administration | 2007 |
Risk reduction with clopidogrel in the management of peripheral arterial disease.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine | 2007 |
Upper GI risks of NSAIDs and antiplatelet agents: key issues for the cardiologist.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cardiology; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Health Care Costs; Helicobacter Infections; Helicobacter pylori; Humans; Patient Selection; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Stomach Ulcer; Ticlopidine | 2005 |
[Management coronary syndrome in the acute phase].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
[Long-term management of post acute coronary syndrome with oral antiplatelet therapy].
Topics: Acute Coronary Syndrome; Administration, Oral; Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Registries; Ticlopidine | 2007 |
[What should be done after the first TIA?].
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Diuretics; Drug Therapy, Combination; Electrocardiography; Endarterectomy, Carotid; Humans; Indapamide; Ischemic Attack, Transient; Life Style; Middle Aged; Perindopril; Platelet Aggregation Inhibitors; Prognosis; Risk Factors; Stroke; Ticlopidine; Time Factors; Tomography, X-Ray Computed | 2007 |
[Current aspects of secondary prevention of ischemic stroke].
Topics: Aspirin; Cerebral Infarction; Cholesterol, LDL; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Evidence-Based Medicine; Feeding Behavior; Humans; Life Style; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Secondary Prevention; Ticlopidine | 2007 |
Antiplatelet therapy in cerebrovascular disease: implications of Management of Artherothrombosis with Clopidogrel in High-risk Patients and the Clopidogrel for High Artherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance studies' resu
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Embolism, Cholesterol; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stroke; Ticlopidine | 2007 |
Platelet function testing: state of the art.
Topics: Aspirin; Clopidogrel; Drug Resistance; Flow Cytometry; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2007 |
The PRoFESS trial: future impact on secondary stroke prevention.
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Benzimidazoles; Benzoates; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Forecasting; Humans; Internationality; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke; Telmisartan; Ticlopidine; Treatment Outcome; Vasodilator Agents | 2007 |
Greater inhibition of platelet aggregation and reduced response variability with prasugrel versus clopidogrel: an integrated analysis.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Bayes Theorem; Clinical Trials, Phase I as Topic; Clopidogrel; Databases, Factual; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Treatment Outcome | 2007 |
Prevention of secondary stroke and transient ischaemic attack with antiplatelet therapy: the role of the primary care physician [corrected].
Topics: Aged; Aspirin; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Drug Therapy, Combination; Family Practice; Humans; Ischemic Attack, Transient; Middle Aged; Physician's Role; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2007 |
Antithrombotic therapy and the transition to the catheterization laboratory in UA/NSTEMI.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Electrocardiography; Evidence-Based Medicine; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Ticlopidine; Treatment Outcome | 2007 |
Clopidogrel: who, when, and how?
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Ischemia; Patient Selection; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Secondary Prevention; Syndrome; Ticlopidine; Treatment Outcome | 2007 |
Meta-analysis appraising high clopidogrel loading in patients undergoing percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Stenosis; Drug Administration Schedule; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Randomized Controlled Trials as Topic; Ticlopidine | 2007 |
Coronary stents and noncardiac surgery.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug-Eluting Stents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Surgical Procedures, Operative; Thrombosis; Ticlopidine | 2007 |
Drug evaluation of clopidogrel in patients with ischemic stroke.
Topics: Animals; Carotid Artery Thrombosis; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2007 |
Management of an acute coronary syndrome in a patient with severe haemophilia A.
Topics: Acute Coronary Syndrome; Antifibrinolytic Agents; Aspirin; Clopidogrel; Fibrinolytic Agents; Hemophilia A; Hemostatics; Heparin; Humans; Life Expectancy; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2007 |
Monitoring of the antiplatelet drugs effect in patients with coronary artery disease: what is the real clinical impact?
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Monitoring; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2007 |
Platelet function monitoring in patients with coronary artery disease.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Disease; Drug Resistance; Humans; Monitoring, Physiologic; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Ticlopidine; Treatment Outcome | 2007 |
Low-dose aspirin and clopidogrel: how to act in patients scheduled for day surgery.
Topics: Anesthesia; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Practice Guidelines as Topic; Risk Assessment; Ticlopidine | 2007 |
Clopidogrel and risk for acute coronary events.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2007 |
Aspirin and clopidogrel resistance.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clopidogrel; Coronary Thrombosis; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Ticlopidine | 2007 |
[Late coronary stent thrombosis and clopidogrel].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
ADP receptor antagonism: what's in the pipeline?
Topics: Adenosine; Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Disease; Humans; Membrane Proteins; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2007 |
Monitoring the ACTIVE-W trial: some issues in monitoring a noninferiority trial.
Topics: Administration, Oral; Anticoagulants; Aspirin; Atrial Fibrillation; Biphenyl Compounds; Clinical Trials Data Monitoring Committees; Clopidogrel; Decision Making; Female; Humans; Irbesartan; Male; Prognosis; Randomized Controlled Trials as Topic; Research Design; Risk Assessment; Sensitivity and Specificity; Survival Analysis; Tetrazoles; Ticlopidine; Treatment Outcome | 2008 |
Aspirin combined with clopidogrel (Plavix) decreases cardiovascular events in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Angina, Unstable; Aspirin; Clopidogrel; Coronary Artery Disease; Evidence-Based Medicine; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2007 |
[Optimizing antithrombotic therapy in non-ST-elevation acute coronary syndrome].
Topics: Acute Coronary Syndrome; Anticoagulants; Clopidogrel; Fibrinolytic Agents; Fondaparinux; Hirudins; Humans; Peptide Fragments; Polysaccharides; Recombinant Proteins; Ticlopidine | 2007 |
Increased incidence of in-stent thrombosis related to cocaine use: case series and review of literature.
Topics: Adult; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cocaine; Cocaine-Related Disorders; Coronary Artery Disease; Coronary Thrombosis; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2007 |
Antiplatelet therapy for stroke prevention.
Topics: Anticoagulants; Aspirin; Atherosclerosis; Atrial Fibrillation; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2007 |
P2Y12 antagonism: promises and challenges.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clinical Trials, Phase III as Topic; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Education, Medical, Continuing; Female; Humans; Male; Maximum Tolerated Dose; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Risk Assessment; Survival Analysis; Ticlopidine; Treatment Outcome | 2008 |
Antiplatelet agents and randomized trials.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke; Ticlopidine | 2007 |
Facilitated PCI: rationale, current evidence, open questions, and future directions.
Topics: Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Fibrinolytic Agents; Humans; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2008 |
Antiplatelet therapy with clopidogrel and aspirin in vascular diseases: clinical evidence for and against the combination.
Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
[Platelet response to aspirin and clopidogrel. Biochemical evaluation, clinical impact, and pharmacological modulation].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Flow Cytometry; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2007 |
[Gp IIb/IIIa receptor antagonists in acute coronary syndromes with no ST elevation].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Hirudins; Humans; Myocardial Infarction; Myocardial Revascularization; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Recombinant Proteins; Ticlopidine; Troponin T | 2007 |
Clopidogrel desensitization: case report and review of published protocols.
Topics: Cardiac Catheterization; Clinical Protocols; Clopidogrel; Coronary Artery Disease; Desensitization, Immunologic; Drug Hypersensitivity; Drug-Eluting Stents; Exanthema; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Do patients with acute myocardial infarction benefit from treatment with clopidogrel?
Topics: Adult; Clopidogrel; Emergency Medical Services; Evidence-Based Medicine; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2008 |
Current update on glycoprotein IIb-IIIa and direct thrombin inhibition in percutaneous coronary intervention for non-ST elevation acute coronary syndromes: balancing bleeding risk and antiplatelet efficacy.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Antithrombins; Aspirin; Clopidogrel; Enoxaparin; Eptifibatide; Fibrinolytic Agents; Heart Conduction System; Hemorrhage; Heparin; Hirudins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Risk Assessment; Risk Factors; Ticlopidine | 2008 |
[Drug-eluting stent thrombosis and its pharmacological prevention].
Topics: Aspirin; Clopidogrel; Death, Sudden, Cardiac; Drug-Eluting Stents; Fibrinolytic Agents; Humans; Incidence; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Terminology as Topic; Thrombosis; Ticlopidine; Turkey | 2007 |
[Clopidogrel resistance: myth or reality].
Topics: Clopidogrel; Coronary Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Prognosis; Risk Factors; Ticlopidine | 2007 |
[Clopidogrel and statins or once more on the danger of direct transfer of results of experimental studies in clinical practice].
Topics: Atorvastatin; Clopidogrel; Coronary Thrombosis; Diabetes Mellitus, Type 2; Heptanoic Acids; Humans; Hypercholesterolemia; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2008 |
[Monitoring of antiplatelet drug effects--fashion or necessity?].
Topics: Acenocoumarol; Aspirin; Blood Platelets; Clopidogrel; Drug Monitoring; Heparin; Humans; International Normalized Ratio; Partial Thromboplastin Time; Platelet Aggregation Inhibitors; Platelet Function Tests; Prothrombin Time; Ticlopidine | 2008 |
Mortality benefit from unrestricted access to clopidogrel: too good to be true?
Topics: Angioplasty, Balloon, Coronary; Canada; Clopidogrel; Coronary Restenosis; Drug Prescriptions; Health Services Accessibility; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Survival Rate; Ticlopidine | 2008 |
ST-elevation myocardial infarction: the role of adjunctive antiplatelet therapy.
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Clopidogrel; Electrocardiography; Eptifibatide; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Ticlopidine; Tirofiban; Tyrosine | 2008 |
[Pharmacoeconomic evaluation of clopidogrel in acute coronary syndromes. Long-term treatment, secondary prophylaxis, and percutaneous coronary intervention].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Economics, Pharmaceutical; Health Care Costs; Humans; Internationality; Longitudinal Studies; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
[Antithrombotic therapy after percutanous coronary intervention with stenting].
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug-Eluting Stents; Fibrinolytic Agents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine; Time Factors; Warfarin | 2008 |
[Methods to evaluate aspirin and clopidogrel resistance].
Topics: Aspirin; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Clopidogrel-associated bleeding and related complications in patients undergoing coronary artery bypass grafting.
Topics: Blood Loss, Surgical; Blood Transfusion; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Humans; Intraoperative Complications; Platelet Aggregation Inhibitors; Reoperation; Ticlopidine | 2008 |
Translational therapeutics at the platelet vascular interface. Summary.
Topics: Angina, Unstable; Animals; Aspirin; Blood Platelets; Clopidogrel; Disease Models, Animal; Drug Evaluation, Preclinical; Education, Medical, Continuing; Humans; Mice; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Secondary Prevention; Sensitivity and Specificity; Survival Analysis; Ticlopidine; Treatment Outcome | 2008 |
Use of drug-eluting stents in saphenous vein aortocoronary bypass graft lesions: a critical appraisal.
Topics: Aorta; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Drug-Eluting Stents; Humans; Saphenous Vein; Ticlopidine | 2008 |
Indications for dual antiplatelet therapy with aspirin and clopidogrel: evidence-based recommendations for use.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Brain Ischemia; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Drug-Eluting Stents; Evidence-Based Medicine; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2008 |
Individualized antithrombotic therapy in high risk patients after coronary stenting. A double-edged sword between thrombosis and bleeding.
Topics: Algorithms; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Blood Coagulation; Clopidogrel; Drug Resistance; Evidence-Based Medicine; Fibrinolytic Agents; Hemorrhage; Humans; Patient Selection; Perioperative Care; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine | 2008 |
Recent developments in acute coronary syndromes.
Topics: Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Antithrombins; Clopidogrel; Fondaparinux; Heparin, Low-Molecular-Weight; Hirudins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polysaccharides; Recombinant Proteins; Thrombolytic Therapy; Ticlopidine | 2008 |
[Platelet aggregation inhibition in acute coronary syndrome. Facts and expectations].
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Resistance; Drugs, Investigational; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Meta-analysis of the efficacy and safety of clopidogrel plus aspirin as compared to antiplatelet monotherapy for the prevention of vascular events.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome; Vascular Diseases | 2008 |
Antiplatelet therapy in acute coronary syndromes: the emergency physician's perspective.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass; Dose-Response Relationship, Drug; Emergency Medicine; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2008 |
Role of antiplatelet agents in the primary and secondary prevention of atherothrombotic events in high risk-patients.
Topics: Aspirin; Atherosclerosis; Clinical Trials as Topic; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Ischemia; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Thrombosis; Ticlopidine | 2008 |
Use of antiplatelet agents to prevent stroke: what is the role for combinations of medications?
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Interactions; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Stroke; Ticlopidine | 2008 |
Antiplatelet drug nonresponsiveness.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Coronary Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2008 |
Interaction effects and subgroup analyses in clinical trials: more than meets the eye?
Topics: Aspirin; Bias; Causality; Clinical Trials as Topic; Clopidogrel; Confounding Factors, Epidemiologic; Data Interpretation, Statistical; Effect Modifier, Epidemiologic; Factor Analysis, Statistical; Humans; Incidence; Linear Models; Platelet Aggregation Inhibitors; Probability; Reproducibility of Results; Research Design; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Guideline on antiplatelet and anticoagulation management in cardiac surgery.
Topics: Anticoagulants; Aprotinin; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Evidence-Based Medicine; Heart Valve Prosthesis Implantation; Hemostasis, Surgical; Hemostatics; Humans; Monitoring, Intraoperative; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine; Tranexamic Acid; Warfarin | 2008 |
Clopidogrel use in coronary heart disease and percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Drug Interactions; Drug Resistance; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
[Frequently asked questions on clopidogrel treatment: indications, resistance, and biological evaluation in vascular patients].
Topics: Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Antiplatelet therapy for vascular interventions.
Topics: Angioplasty, Balloon; Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Humans; Inguinal Canal; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Vascular Surgical Procedures | 2008 |
Will prasugrel supersede clopidogrel for acute coronary syndromes?
Topics: Acute Coronary Syndrome; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Artery Bypass; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Ticlopidine | 2008 |
Antiplatelet agents and arterial thrombosis.
Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Primary Prevention; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine; Warfarin | 2008 |
Antithrombotic and thrombolytic therapy for ischemic stroke.
Topics: Aspirin; Benzenesulfonates; Cardiomyopathies; Clopidogrel; Comorbidity; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Neuroprotective Agents; Platelet Aggregation Inhibitors; Primary Prevention; Stroke; Stroke Volume; Thrombolytic Therapy; Ticlopidine | 2008 |
Chronic antithrombotic therapy in post-myocardial infarction patients.
Topics: Anticoagulants; Aspirin; Azetidines; Benzylamines; Clopidogrel; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Thrombolytic Therapy; Thrombosis; Ticlopidine; Vitamin K; Warfarin | 2008 |
Update on antiplatelet agents, including MATCH, CHARISMA, and ESPRIT.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Coronary Artery Disease; Dipyridamole; Female; Humans; Ischemic Attack, Transient; Male; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2008 |
Antiplatelet therapy in early management of non-ST-segment elevation acute coronary syndrome: the 2002 and 2007 guidelines from North America and Europe.
Topics: Acute Coronary Syndrome; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Contraindications; Europe; Humans; North America; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Ticlopidine | 2008 |
Aspirin and platelet adenosine diphosphate receptor antagonists in acute coronary syndromes and percutaneous coronary intervention: role in therapy and strategies to overcome resistance.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticlopidine; Treatment Outcome | 2008 |
Managing antiplatelet therapy in the ACS patient: straight from the emergency department to you.
Topics: Acute Coronary Syndrome; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Emergency Treatment; Hospitalists; Humans; Myocardial Revascularization; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Review of the 2005 American College of Cardiology, American Heart Association, and Society for Cardiovascular Interventions guidelines for adjunctive pharmacologic therapy during percutaneous coronary interventions: practical implications, new clinical da
Topics: American Heart Association; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Disease; Drug-Eluting Stents; Hirudins; Humans; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Pyridines; Recombinant Proteins; Societies, Medical; Thrombolytic Therapy; Ticlopidine; United States | 2008 |
Efficacy and safety of clopidogrel pretreatment before percutaneous coronary intervention with and without glycoprotein IIb/IIIa inhibitor use.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2008 |
Effects of glycoprotein IIb/IIIa inhibitors in patients undergoing percutaneous coronary intervention after pretreatment with clopidogrel: a meta-analysis of randomized trials.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Confidence Intervals; Coronary Angiography; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Odds Ratio; Platelet Glycoprotein GPIIb-IIIa Complex; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Sensitivity and Specificity; Survival Analysis; Ticlopidine; Treatment Outcome | 2008 |
Aspirin, clopidogrel, and warfarin: is the combination appropriate and effective or inappropriate and too dangerous?
Topics: Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Hemorrhage; Humans; Ischemia; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine; Vascular Diseases; Warfarin | 2008 |
Antiplatelet strategies: evaluating their current role in the setting of acute coronary syndromes.
Topics: Abciximab; Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Investigating the mechanisms of hyporesponse to antiplatelet approaches.
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Genetic Predisposition to Disease; Humans; Patient Selection; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2008 |
Clinical considerations with the use of antiplatelet therapy in patients undergoing percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Guideline Adherence; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Safety of clopidogrel and aspirin for stroke prevention: implications of the CHARISMA trial.
Topics: Animals; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2008 |
Interpreting the CHARISMA study. What is the role of dual antiplatelet therapy with clopidogrel and aspirin?
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine | 2008 |
Impact of duration of clopidogrel prescription on outcome of DES as compared to BMS in primary angioplasty: a meta-regression analysis of randomized trials.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prescriptions; Randomized Controlled Trials as Topic; Regression Analysis; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Prasugrel: a novel antiplatelet agent.
Topics: Acute Coronary Syndrome; Animals; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Thrombolytic Therapy; Ticlopidine | 2008 |
Antiplatelet and anticoagulant agents: key differences in mechanisms of action, clinical application, and therapeutic benefit in patients with non-ST-segment-elevation acute coronary syndromes.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Hirudins; Humans; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Ticlopidine | 2008 |
Clopidogrel in secondary ischemic stroke prevention.
Topics: Aspirin; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Patient Selection; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Secondary Prevention; Stroke; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2008 |
Dual antiplatelet therapy with clopidogrel and aspirin.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Contraindications; Coronary Artery Bypass; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Polypharmacy; Ticlopidine | 2008 |
The year in interventional cardiology.
Topics: Acute Coronary Syndrome; American Heart Association; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Drug-Eluting Stents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; United States | 2008 |
[Clopidogrel--clinical use and potential therapeutic problems].
Topics: Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart Diseases; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Stents; Thrombosis; Ticlopidine | 2008 |
Clopidogrel and coronary stents: risks and benefits.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Vessels; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2008 |
Antithrombotic therapy in patients treated with oral anticoagulation undergoing coronary artery stenting. An expert consensus document with focus on atrial fibrillation.
Topics: Administration, Oral; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Revascularization; Postoperative Care; Stents; Thrombosis; Ticlopidine; Warfarin | 2008 |
Antiplatelet treatment of cardiovascular disease: a translational research perspective.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2008 |
Coronary artery stents: II. Perioperative considerations and management.
Topics: Anesthesia, Conduction; Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Coronary Vessels; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Stents; Surgical Procedures, Operative; Ticlopidine | 2008 |
Current antiplatelet therapies: benefits and limitations.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2008 |
Interaction between statins and clopidogrel: is there anything clinically relevant?
Topics: Clopidogrel; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Clinical implications of clopidogrel resistance.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Drug Resistance; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Oral antiplatelet agents and bleeding risk in relation to major cardiovascular surgery.
Topics: Aspirin; Cardiovascular Surgical Procedures; Cilostazol; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk; Tetrazoles; Ticlopidine | 2006 |
Acetylsalicylic acid + extended-release dipyridamole combination therapy for secondary stroke prevention.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Stroke; Ticlopidine | 2008 |
Revascularization treatment recommendations based on atherosclerotic disease distribution: coronary artery bypass grafting versus stenting.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Coronary Stenosis; Coronary Vessels; Diabetic Angiopathies; Drug-Eluting Stents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Reoperation; Stents; Ticlopidine; Treatment Outcome | 2008 |
Treatment strategies in non-ST-elevation acute coronary syndromes in patients undergoing percutaneous coronary intervention: an evidence-based review of clinical trial results and treatment guidelines: report on a roundtable discussion.
Topics: Acute Coronary Syndrome; Algorithms; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cardiovascular Agents; Clinical Trials as Topic; Clopidogrel; Emergency Treatment; Evidence-Based Medicine; Fibrinolytic Agents; Hirudins; Humans; Peptide Fragments; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Hemorrhage; Practice Guidelines as Topic; Prasugrel Hydrochloride; Recombinant Proteins; Risk Assessment; Stents; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Clinical implications of aspirin resistance.
Topics: Aspirin; Atherosclerosis; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Drug Resistance; Humans; Ischemia; Research Design; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
The approach to optimizing stroke care.
Topics: Aspirin; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Emergency Service, Hospital; Fibrinolytic Agents; Guidelines as Topic; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2008 |
Reducing the risk of adverse thrombotic events - The role of aspirin and clopidogrel.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2008 |
Pre-procedural C-reactive protein levels and clinical outcomes after percutaneous coronary interventions with and without abciximab: pooled analysis of four ISAR trials.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Biomarkers; C-Reactive Protein; Clopidogrel; Coronary Disease; Female; Humans; Immunoglobulin Fab Fragments; Male; Multicenter Studies as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Preoperative Care; Prognosis; Randomized Controlled Trials as Topic; Ticlopidine | 2009 |
Combination antiplatelet agents for secondary prevention of ischemic stroke.
Topics: Aspirin; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2008 |
Antiplatelet drugs in cardiological practice: established strategies and new developments.
Topics: Atherosclerosis; Clopidogrel; Drug-Eluting Stents; Humans; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Receptors, Thromboxane; Signal Transduction; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Application of covered stent grafts for intracranial vertebral artery dissecting aneurysms.
Topics: Adult; Aortic Dissection; Clopidogrel; Female; Fibrinolytic Agents; Humans; Intracranial Aneurysm; Intracranial Thrombosis; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome; Vertebral Artery | 2009 |
Impact of pretreatment with clopidogrel on initial patency and outcome in patients treated with primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a systematic review.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Thrombosis; Electrocardiography; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2008 |
Clopidogrel and aspirin in cardiovascular medicine: responders or not--current best available evidence.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Drug-eluting stents and antiplatelet resistance.
Topics: Aspirin; Clopidogrel; Drug Resistance; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2008 |
Intensity of antiplatelet therapy in patients with acute coronary syndromes and percutaneous coronary intervention: the promise of prasugrel?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Clopidogrel: review of bioanalytical methods, pharmacokinetics/pharmacodynamics, and update on recent trends in drug-drug interaction studies.
Topics: Atorvastatin; Clopidogrel; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Indoles; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Ticlopidine | 2009 |
Aspirin and clopidogrel response variability: review of the published literature.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine | 2008 |
Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future.
Topics: Adenosine; Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; History, 20th Century; History, 21st Century; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2008 |
Digestion of the antiplatelets comparison of PRoFESS: 18-7=1?
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine; Treatment Outcome | 2009 |
Diabetes, vascular complications and antiplatelet therapy: open problems.
Topics: Aspirin; Clopidogrel; Diabetes Mellitus; Diabetic Angiopathies; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
[Current issues of anticoagulation therapy in the course of dental treatment and oral surgery].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Dental Care; Dipyridamole; Drug Administration Schedule; Drug Combinations; Humans; Oral Surgical Procedures; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
The genetics of antiplatelet drug resistance.
Topics: Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2009 |
Is prasugrel more effective than clopidogrel in patients with acute coronary syndrome scheduled for PCI?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticlopidine; Treatment Outcome | 2008 |
[Acute intervention for ST-elevation myocardial infarction].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; History, 20th Century; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prognosis; Stents; Thrombolytic Therapy; Ticlopidine; Time Factors | 2008 |
Antiplatelet drug response variability and the role of platelet function testing: a practical guide for interventional cardiologists.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Myocardial Ischemia; Patient Compliance; Patient Selection; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Practice Guidelines as Topic; Predictive Value of Tests; Recurrence; Risk Assessment; Stents; Ticlopidine; Treatment Failure; Treatment Outcome | 2009 |
The rationale for and comparisons of different antiplatelet treatments in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Eptifibatide; Humans; Ischemia; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine; Treatment Outcome | 2008 |
Multifunctional actions of approved and candidate stroke drugs.
Topics: Albumins; Animals; Antihypertensive Agents; Aspirin; Brain Ischemia; Clopidogrel; Cytidine Diphosphate Choline; Dipyridamole; Erythropoietin; Granulocyte Colony-Stimulating Factor; Humans; Hypolipidemic Agents; Neuroprotective Agents; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2009 |
[Variable platelet response to aspirin and new therapeutic targets].
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
PPI interactions with clopidogrel.
Topics: Anti-Ulcer Agents; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Gastroesophageal Reflux; Humans; Incidence; Peptic Ulcer; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stents; Ticlopidine | 2009 |
[Resistance to platelet antiaggregants: the cardiologist's point of view].
Topics: Aspirin; Cardiology; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2009 |
Contemporary issues on clopidogrel therapy.
Topics: Acute Coronary Syndrome; Clopidogrel; Dose-Response Relationship, Drug; Humans; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Prasugrel development - claims and achievements.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Animals; Aspirin; Blood Platelets; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drug Administration Schedule; Drug Discovery; Drug Resistance; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Research Design; Risk Assessment; Stents; Thiophenes; Ticlopidine; Treatment Outcome | 2009 |
What's new in stroke? The top 10 studies of 2006-2008. Part I.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Evidence-Based Medicine; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2008 |
Current problems, new opportunities and future directions of anti-platelet therapy - increasing role of novel antiplatelet agents in cardiovascular diseases.
Topics: Adenosine; Adenosine Monophosphate; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Humans; Imines; Lactones; Patents as Topic; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Receptor, PAR-1; Receptors, Purinergic P2Y12; Receptors, Thrombin; Thiophenes; Ticagrelor; Ticlopidine | 2009 |
Role of antiplatelet therapy across the spectrum of patients with coronary artery disease.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Variability in responsiveness to oral antiplatelet therapy.
Topics: Acute Coronary Syndrome; Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Signal Transduction; Ticlopidine; Treatment Outcome | 2009 |
Monitoring platelet function to reduce the risk of ischemic and bleeding complications.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Hemorrhage; Humans; Ischemia; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Risk Factors; Sensitivity and Specificity; Ticlopidine; Treatment Outcome | 2009 |
[Risk of gastrointestinal bleeding with aspirin and platelet antiaggregants].
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Middle Aged; Misoprostol; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Thromboxanes; Ticlopidine | 2009 |
Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working
Topics: Aspirin; Clopidogrel; Coronary Disease; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989-2008).
Topics: ADAM Proteins; ADAMTS13 Protein; Adverse Drug Reaction Reporting Systems; Animals; Autoantibodies; Clopidogrel; Epidemiologic Studies; Humans; Plasma Exchange; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Renal Insufficiency; Risk Factors; Ticlopidine; Treatment Outcome | 2009 |
Optimizing long-term dual aspirin/clopidogrel therapy in acute coronary syndromes: when does the risk outweigh the benefit?
Topics: Acute Coronary Syndrome; Administration, Oral; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2009 |
Emergence of the concept of platelet reactivity monitoring of response to thienopyridines.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Pyridines; Ticlopidine | 2009 |
Antiplatelet therapy after endovascular intervention: does combination therapy really work and what is the optimum duration of therapy?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Vessel Prosthesis Implantation; Cardiovascular Diseases; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Evidence-Based Medicine; Graft Occlusion, Vascular; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2009 |
Combination antiplatelet therapy in patients with peripheral arterial disease: is the best therapy aspirin, clopidogrel, or both?
Topics: Aspirin; Atherosclerosis; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Evidence-Based Medicine; Hemodynamics; Hemorrhage; Humans; Ischemia; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Risk Assessment; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
[Resistance to desaggregants: causes, clinical implication, methods of diagnosis and correction].
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Antiplatelet agents for prevention of recurrent ischemic stroke.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stroke; Ticlopidine | 2009 |
Clopidogrel resistance: pharmacokinetic or pharmacogenetic?
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Resistance; Humans; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2009 |
[Routine platelet aggregation inhibition not useful when using acetylsalicylic acid or clopidogrel].
Topics: Aspirin; Clopidogrel; Drug Resistance; Humans; Mass Screening; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Ticlopidine; Treatment Failure | 2009 |
Antiplatelet therapy in percutaneous coronary intervention: integration of prasugrel into clinical practice.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Severity of Illness Index; Survival Analysis; Thiophenes; Thromboembolism; Ticlopidine; Treatment Outcome | 2009 |
Variability in platelet response to the antiplatelet agents aspirin and clopidogrel: mechanisms, measurement, and clinical relevance.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Probability; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Ticlopidine; Treatment Outcome | 2009 |
Unmet needs in oral antiplatelet therapy with ADP receptor blocking agents.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Administration, Oral; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2009 |
Benefits and risks of clopidogrel use in patients with coronary artery disease: evidence from randomized studies and registries.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Registries; Risk Assessment; Ticlopidine | 2008 |
Antiplatelet therapy and coronary artery bypass graft surgery: perioperative safety and efficacy.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Drug Therapy, Combination; Humans; Meta-Analysis as Topic; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Period; Randomized Controlled Trials as Topic; Risk Assessment; Ticlopidine | 2009 |
Recent advances in the management of coronary artery disease: highlights from the literature.
Topics: Blood Vessels; Clopidogrel; Coronary Angiography; Coronary Artery Bypass, Off-Pump; Coronary Artery Disease; Exercise Test; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Revascularization; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Tomography, Emission-Computed; Treatment Outcome | 2009 |
Does timing matter? Upstream or downstream administration of antiplatelet therapy.
Topics: Acute Coronary Syndrome; Algorithms; Aspirin; Clopidogrel; Coronary Angiography; Drug Administration Schedule; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Ticlopidine | 2009 |
Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future directions.
Topics: Aspirin; Clopidogrel; Diabetes Mellitus; Diabetic Angiopathies; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Secondary Prevention; Ticlopidine | 2009 |
Response variability and the role of platelet function testing.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
Antiplatelet drugs for ischemic stroke prevention.
Topics: Aged; Anticoagulants; Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Patient Selection; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Primary Prevention; Risk Assessment; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2009 |
Antiplatelet drug 'resistance'. Part 1: mechanisms and clinical measurements.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Humans; Medication Adherence; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Predictive Value of Tests; Ticlopidine; Treatment Failure | 2009 |
Percutaneous coronary intervention: assessing coronary vascular risk associated with bare-metal and drug-eluting stents.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine | 2009 |
Acute coronary syndrome and its antithrombotic treatment: focus on aspirin and clopidogrel resistance.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Resistance; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2009 |
Combination antiplatelet therapy for secondary stroke prevention: enhanced efficacy or double trouble?
Topics: Anticoagulants; Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Dipyridamole; Drug Combinations; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2009 |
Clopidogrel in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug-Eluting Stents; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2009 |
Significant gastrointestinal bleeding in patients at risk of coronary stent thrombosis.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anti-Bacterial Agents; Aspirin; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Duodenal Ulcer; Endoscopy, Gastrointestinal; Female; Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Prasugrel in acute coronary syndrome patients undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2009 |
Antiplatelet therapy in ischemic stroke: variability in clinical trials and its impact on choosing the appropriate therapy.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Atherosclerosis; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Confounding Factors, Epidemiologic; Decision Making; Dipyridamole; Double-Blind Method; Drug Therapy, Combination; Evidence-Based Medicine; Female; Follow-Up Studies; Hemorrhage; Humans; Ischemic Attack, Transient; Male; Middle Aged; Multicenter Studies as Topic; Patient Selection; Platelet Aggregation Inhibitors; Research Design; Secondary Prevention; Ticlopidine | 2009 |
New antiplatelet drugs: beyond aspirin and clopidogrel.
Topics: Adenosine; Adenosine Monophosphate; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Drug Design; Humans; Imines; Lactones; Naphthalenes; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Propionates; Purinergic P2 Receptor Antagonists; Pyridines; Thiophenes; Ticagrelor; Ticlopidine | 2009 |
Clopidogrel-induced hepatocellular injury and cholestatic jaundice in an elderly patient: case report and review of the literature.
Topics: Aged; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Clopidogrel; Female; Humans; Jaundice, Obstructive; Liver Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Critical review of prasugrel for formulary decision makers.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug Interactions; Formularies, Hospital as Topic; Humans; Managed Care Programs; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Risk Assessment; Thiophenes; Ticlopidine | 2009 |
Possibility of a rebound phenomenon following antiplatelet therapy withdrawal: a look at the clinical and pharmacological evidence.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Ticlopidine; Withholding Treatment | 2009 |
Diabetes mellitus: a prothrombotic state implications for outcomes after coronary revascularization.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Diabetes Mellitus, Type 2; Drug-Eluting Stents; Female; Humans; Medication Adherence; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Sirolimus; Ticlopidine; Treatment Outcome | 2009 |
Use of clopidogrel in the reduction of myocardial damage during percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Biomarkers; Clopidogrel; Creatine Kinase, MB Form; Drug Administration Schedule; Drug Therapy, Combination; Humans; Myocardial Infarction; Myocardium; Necrosis; Patient Selection; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome; Troponin | 2009 |
Prasugrel for the treatment of patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Administration, Oral; Angioplasty, Balloon, Coronary; Animals; Clinical Trials as Topic; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Treatment Outcome | 2009 |
[New approach to interventional cardiology treatment with personalized medicine].
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Drug Resistance; Hematologic Diseases; Humans; Myocardial Infarction; Personal Health Services; Ticlopidine; Treatment Failure | 2008 |
Management of patients with high gastrointestinal risk on antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Peptic Ulcer Hemorrhage; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Risk Factors; Thiophenes; Ticlopidine | 2009 |
Prasugrel: newest antiplatelet agent and its emerging role in management of acute coronary syndrome and percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticlopidine | 2009 |
Bedside evaluation of thienopyridine antiplatelet therapy.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Drug Therapy, Combination; Humans; Mass Screening; Myocardial Infarction; Nephelometry and Turbidimetry; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Point-of-Care Systems; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Thrombelastography; Ticlopidine; United States | 2009 |
[Drug-eluting stents: implications for modern coronary revascularization].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Bias; Clopidogrel; Comorbidity; Coronary Artery Bypass; Coronary Restenosis; Drug Therapy, Combination; Drug-Eluting Stents; Guideline Adherence; Hemorrhage; Humans; Intraoperative Complications; Long-Term Care; Platelet Aggregation Inhibitors; Publication Bias; Reoperation; Substance Withdrawal Syndrome; Survival Rate; Ticlopidine; Treatment Outcome | 2009 |
Peri-procedural platelet function and platelet inhibition in percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Resistance; Hemorrhage; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Thrombin; Ticlopidine; Treatment Outcome | 2008 |
P2X(1) receptor inhibition and soluble CD39 administration as novel approaches to widen the cardiovascular therapeutic window.
Topics: Adenosine Triphosphate; Antigens, CD; Apyrase; Aspirin; Biomedical Research; Cardiovascular Diseases; Cerebral Hemorrhage; Clinical Trials as Topic; Clopidogrel; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Endothelium, Vascular; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2009 |
Drug-drug interaction between clopidogrel and the proton pump inhibitors.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aryl Hydrocarbon Hydroxylases; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2009 |
Antiplatelet therapy in percutaneous coronary intervention: a critical review of the 2007 AHA/ACC/SCAI guidelines and beyond.
Topics: American Heart Association; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Evidence-Based Medicine; Humans; Medication Adherence; Metals; Patient Selection; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Prosthesis Design; Risk Assessment; Stents; Ticlopidine; Treatment Outcome; United States | 2009 |
Improving outcomes in patients undergoing percutaneous coronary intervention: role of prasugrel.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Diabetes Complications; Drug Resistance; Drug Therapy, Combination; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Risk Factors; Stents; Thiophenes; Ticlopidine; Treatment Outcome | 2009 |
Clopidogrel in the management of acute coronary syndromes: indications, results, obstacles.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Review of prasugrel for the secondary prevention of atherothrombosis.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Atherosclerosis; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Thrombosis; Ticlopidine | 2009 |
Hospitals with and without percutaneous coronary intervention capability: considerations for treating acute coronary syndromes.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Emergency Service, Hospital; Enoxaparin; Fondaparinux; Health Services Accessibility; Hirudins; Humans; Peptide Fragments; Platelet Aggregation Inhibitors; Polysaccharides; Recombinant Proteins; Ticlopidine; Triage; United States | 2009 |
Aggressive chronic platelet inhibition with prasugrel and increased cancer risks: revising oral antiplatelet regimens?
Topics: Animals; Aspirin; Clopidogrel; Colonic Neoplasms; Gastrointestinal Hemorrhage; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2009 |
[Pharmacogenomics].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Camptothecin; Cetuximab; Clopidogrel; Humans; Irinotecan; Pharmacogenetics; Tegafur; Ticlopidine | 2009 |
A new generation of antiplatelet agents.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thrombin; Ticlopidine; von Willebrand Factor | 2009 |
Platelet resistance to antiplatelet drugs.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Resistance, Multiple; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Diabetes and acute coronary syndromes.
Topics: Acute Coronary Syndrome; Anticoagulants; Aspirin; Blood Glucose; Clopidogrel; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enoxaparin; Hirudins; Humans; Hypoglycemic Agents; Peptide Fragments; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Recombinant Proteins; Thiophenes; Thrombosis; Ticlopidine | 2009 |
Aspirin and clopidogrel: efficacy and resistance in diabetes mellitus.
Topics: Aspirin; Clopidogrel; Diabetes Mellitus; Drug Resistance; Endothelium, Vascular; Humans; Ischemia; Oxidative Stress; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
[Clopidogrel resistance].
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Antithrombotic therapies in cerebrovascular disease: what should we use as secondary prevention in patients with carotid artery disease?
Topics: Anticoagulants; Aspirin; Brain Ischemia; Carotid Stenosis; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Patient Selection; Risk Assessment; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2009 |
Evidence for using clopidogrel alone or in addition to aspirin in post coronary artery bypass surgery patients.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Restenosis; Drug Therapy, Combination; Electrocardiography; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Care; Ticlopidine; Treatment Outcome | 2009 |
New P2Y12 antagonists.
Topics: Clopidogrel; Fibrinolytic Agents; Humans; Platelet Function Tests; Polymorphism, Single Nucleotide; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2009 |
Safety and tolerability of antiplatelet therapies for the secondary prevention of atherothrombotic disease.
Topics: Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine | 2009 |
Clopidogrel response variability: current status and future directions.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
[Prodrug activation as a crucial difference. Prasugrel - a new ADP receptor antagonist].
Topics: Animals; Biotransformation; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Assessment; Thiophenes; Thrombosis; Ticlopidine | 2009 |
[Technological and biopharmaceutical aspects. Antiplatelet agents for oral administration].
Topics: Administration, Oral; Animals; Aspirin; Clopidogrel; Dipyridamole; Humans; Patents as Topic; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
[Diagnosis, causes, relevance of a complex phenomenon. Resistance to aspirin and clopidogrel].
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Interactions; Drug Resistance; Humans; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Thromboxanes; Ticlopidine | 2009 |
[A current problem for regulators. Clopidogrel and pharmacokinetics].
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Industry; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Enzyme Inhibitors; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine; United States; United States Food and Drug Administration | 2009 |
The effect of different treatment durations of clopidogrel in patients with non-ST-segment elevation acute coronary syndromes: a systematic review and value of information analysis.
Topics: Acute Coronary Syndrome; Adolescent; Adult; Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Time Factors; Treatment Outcome; United Kingdom; Withholding Treatment; Young Adult | 2009 |
Recent developments in clopidogrel pharmacology and their relation to clinical outcomes.
Topics: Animals; Body Weight; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2009 |
Assessment, mechanisms, and clinical implication of variability in platelet response to aspirin and clopidogrel therapy.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine | 2009 |
Improving adjunctive pharmacotherapy for primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: beyond the HORIZONS-AMI trial.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Chemotherapy, Adjuvant; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Heparin; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Recombinant Proteins; Risk Assessment; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
[Study of variability in response to aspirin and clopidogrel: clinical and/or biological resistance?].
Topics: Animals; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Animals; Atherosclerosis; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine; Vasoconstriction | 2009 |
Antiplatelet therapy discontinuation following drug-eluting stent placement: dangers, reasons, and management recommendations.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Health Knowledge, Attitudes, Practice; Hemorrhage; Humans; Medication Adherence; Oral Surgical Procedures; Patient Education as Topic; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
P2Y(12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 Enzyme System; Humans; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Thiophenes; Ticlopidine | 2009 |
Inhibition of platelet aggregation with prasugrel and clopidogrel: an integrated analysis in 846 subjects.
Topics: Adult; Clopidogrel; Coronary Artery Disease; Data Collection; Female; Humans; Kinetics; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Young Adult | 2009 |
The present state of aspirin and clopidogrel resistance.
Topics: Anti-Inflammatory Agents; Aspirin; Clopidogrel; Coronary Disease; Drug Monitoring; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2009 |
Prasugrel: a review of its use in patients with acute coronary syndromes undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Adult; Aged; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Clopidogrel; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine; Tissue Distribution; Young Adult | 2009 |
Coronary bypass surgery in patients treated with clopidogrel. Is it safe?
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Treatment Outcome | 2009 |
Coronary stent thrombosis in patients with chronic renal insufficiency.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Humans; Platelet Glycoprotein GPIIb-IIIa Complex; Renal Insufficiency, Chronic; Risk Factors; Stents; Ticlopidine | 2010 |
Challenges in oral antiplatelet therapy: ST-segment elevation myocardial infarction.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
Platelet-directed therapies and coronary artery bypass grafting.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Nonsteroid anti-inflammatory drug-induced gastroduodenal injury.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Drug Interactions; Duodenal Diseases; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Stomach Diseases; Ticlopidine | 2009 |
Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Humans; Kidney Diseases; Platelet Aggregation Inhibitors; Proteinuria; Receptors, Thrombin; Thrombosis; Thromboxane A2; Thromboxane-A Synthase; Ticlopidine | 2009 |
Platelet function testing and implications for clinical practice.
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Hemorrhage; Hemostasis; Humans; Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Assessment; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials.
Topics: Acute Coronary Syndrome; Aged; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Proton Pump Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Ticlopidine; Treatment Outcome | 2009 |
Current controversies in the pharmacogenomics of clopidogrel.
Topics: Clopidogrel; Confidence Intervals; Coronary Artery Disease; Genotype; Humans; Myocardial Infarction; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2009 |
Prasugrel (Effient) vs. clopidogrel (Plavix).
Topics: Animals; Clopidogrel; Drug Approval; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine; United States | 2009 |
Antiplatelet resistance--fact or myth?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2009 |
Dental management of patients taking antiplatelet medications.
Topics: Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Dental Care for Chronically Ill; Humans; Oral Hemorrhage; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Thrombosis; Ticlopidine | 2009 |
Is it safe to use a proton pump inhibitor with clopidogrel?
Topics: Clinical Trials as Topic; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2009 |
Clopidogrel before elective percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Elective Surgical Procedures; Humans; Postoperative Complications; Preoperative Care; Randomized Controlled Trials as Topic; Ticlopidine | 2010 |
Thienopyridine derivatives versus aspirin for preventing stroke and other serious vascular events in high vascular risk patients.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2009 |
[Perioperative antiplatelet therapy of patients with coronary stents].
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Coronary Disease; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Guidelines as Topic; Retrospective Studies; Risk Factors; Stents; Thrombosis; Ticlopidine; Time Factors | 2009 |
Platelet reactivity and nonresponse to dual antiplatelet therapy: a review.
Topics: Blood Platelets; Clinical Trials as Topic; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2009 |
[Thienopyridines in the treatment and prevention of cardiovascular diseases. Part II. Clinical pharmacology of clopidogrel].
Topics: Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Pyridines; Ticlopidine; Treatment Outcome | 2009 |
Antiplatelet treatment in ischemic stroke treatment.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2009 |
Clopidogrel: mechanisms of action and review of the evidence relating to use during skin surgery procedures.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Dermatologic Surgical Procedures; Drug Therapy, Combination; Humans; Perioperative Care; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine | 2010 |
Optimizing antiplatelet therapy in high-risk patients with atrial fibrillation: insights from Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events (ACTIVE A).
Topics: Antihypertensive Agents; Aspirin; Atrial Fibrillation; Biphenyl Compounds; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Contraindications; Humans; Irbesartan; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Tetrazoles; Ticlopidine; Treatment Outcome | 2009 |
[Long-term use of oral antiplatelet therapy: from studies to practice].
Topics: Administration, Oral; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Combinations; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Assessment; Ticlopidine | 2010 |
Platelet monitoring for PCI: is it really necessary?
Topics: Blood Coagulation; Blood Platelets; Clopidogrel; Coronary Disease; Humans; Monitoring, Physiologic; Myocardial Infarction; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine | 2009 |
Dual antiplatelet therapy in coronary artery disease: a case-based approach.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Thiophenes; Ticlopidine | 2009 |
Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk; Ticlopidine | 2009 |
Comparison of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Proton pump inhibitor and clopidogrel interaction: fact or fiction?
Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine | 2010 |
The relative efficacy and safety of clopidogrel in women and men a sex-specific collaborative meta-analysis.
Topics: Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Prevalence; Secondary Prevention; Sex Distribution; Sex Factors; Ticlopidine; Treatment Outcome | 2009 |
Advances in antiplatelet treatment for acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Female; Forecasting; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
[Prevention of GI bleeding due to antiplatelet agents: a labyrinth!].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Lansoprazole; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine | 2009 |
Impact of genetic and acquired alteration in cytochrome P450 system on pharmacologic and clinical response to clopidogrel.
Topics: Aspirin; Calcium Channel Blockers; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Resistance; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polypharmacy; Proton Pump Inhibitors; Ticlopidine | 2010 |
Review of recent evidence: potential interaction between clopidogrel and proton pump inhibitors.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk; Ticlopidine; Time Factors | 2009 |
Variable platelet responsiveness to aspirin and clopidogrel: role of platelet function and genetic polymorphism testing.
Topics: Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2009 |
Gastrointestinal bleed with clopidogrel and aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Ticagrelor--a new platelet aggregation inhibitor in patients with acute coronary syndromes. An improvement of other inhibitors?
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Biotransformation; Clinical Trials as Topic; Clopidogrel; Hemorrhage; Humans; Lactones; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Ticagrelor; Ticlopidine | 2009 |
[Acute coronary syndrome in patients with carbohydrate metabolic disturbances (a review)].
Topics: Acute Coronary Syndrome; Blood Glucose; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2009 |
Prasugrel: a critical comparison with clopidogrel.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Animals; Clinical Trials as Topic; Clopidogrel; Drug Inverse Agonism; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; United States | 2009 |
Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticlopidine | 2010 |
Replacing aspirin and warfarin for secondary stroke prevention: is it worth the costs?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Benzimidazoles; Clopidogrel; Cost-Benefit Analysis; Dabigatran; Humans; Platelet Aggregation Inhibitors; Pyridines; Stroke; Ticlopidine; Warfarin | 2010 |
Antiplatelets and stroke outcomes: state of the science.
Topics: Arachidonic Acid; Aspirin; Aspirin, Dipyridamole Drug Combination; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Combinations; Evidence-Based Practice; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Risk Reduction Behavior; Safety; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2009 |
Aspirin and clopidogrel hyporesponsiveness and nonresponsiveness in patients with coronary artery stenting.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Recurrence; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Update on antiplatelet therapy in acute coronary syndromes: what do new drugs bring into clinical practice?
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Clopidogrel; Humans; Lactones; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticagrelor; Ticlopidine | 2009 |
Antiplatelet agents.
Topics: Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Resistance; Drug Therapy, Combination; Forecasting; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2009 |
[Medicinal therapy for interventional surgery of the peripheral vascular system].
Topics: Administration, Oral; Anticoagulants; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Drug Therapy, Combination; Heparin; Humans; Infusions, Intravenous; Ischemia; Leg; Long-Term Care; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Thrombocytopenia; Thrombosis; Ticlopidine; Vitamin K | 2010 |
Prasugrel: Clinical development and therapeutic application.
Topics: Acute Coronary Syndrome; Angioplasty; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Thrombosis; Ticlopidine | 2009 |
Current standings of the proton pump inhibitor and clopidogrel co-therapy: review on an evolving field with the eyes of the gastroenterologist.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Gastroenterology; Gastrointestinal Hemorrhage; Humans; Myocardial Infarction; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Ticlopidine | 2010 |
A guide to anticoagulation and endocarditis prophylaxis during cutaneous surgery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibiotic Prophylaxis; Anticoagulants; Aspirin; Calcium Channel Blockers; Clopidogrel; Dipyridamole; Endocarditis, Bacterial; Humans; International Normalized Ratio; Perioperative Care; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Skin Diseases; Ticlopidine; Warfarin | 2010 |
[Thienopyridines in the treatment and prevention of cardiovascular diseases. III. therapeutic application of clopidogrel as monotherapy (without acetylsalicylic acid)].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridines; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Ticlopidine; Ulcer | 2009 |
[Thienopyridines in the treatment and prevention of cardiovascular diseases. Part IV. therapeutic application of clopidogrel in combination with acetylsalicylic acid in acute coronary syndromes and percutaneous coronary interventions].
Topics: Acute Coronary Syndrome; American Heart Association; Angioplasty, Balloon; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Thrombosis; Ticlopidine; United States | 2009 |
Clopidogrel-proton pump inhibitor interaction: a primer for clinicians.
Topics: Clopidogrel; Drug Interactions; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Unresolved issues associated with early initiation of antiplatelet therapy in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Time Factors | 2010 |
Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases.
Topics: Adenosine; Adenosine Monophosphate; Benzofurans; Blood Platelets; Carbamates; Clinical Trials as Topic; Clopidogrel; Humans; Lactones; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Receptor, PAR-1; Receptors, Proteinase-Activated; Thiophenes; Ticagrelor; Ticlopidine; von Willebrand Factor | 2010 |
ADP-receptor blockade: A case for personalised pharmacotherapy?
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Precision Medicine; Purinergic P2 Receptor Antagonists; Risk Assessment; Ticlopidine; Treatment Outcome | 2010 |
Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions.
Topics: Atherosclerosis; Clopidogrel; Forecasting; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2010 |
Meta-analysis: the effects of proton pump inhibitors on cardiovascular events and mortality in patients receiving clopidogrel.
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine; Treatment Outcome | 2010 |
[Clopidogrel and proton pump inhibitors--boon or bane?].
Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2010 |
Acute myocardial infarction in a patient with post-splenectomy thrombocytosis: a case report and review of literature.
Topics: Adult; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Follow-Up Studies; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Count; Radiography; Smoking; Splenectomy; Stents; Thrombocytosis; Ticlopidine; Treatment Outcome | 2010 |
Combination antithrombotic therapies.
Topics: Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Pyridines; Thrombosis; Ticlopidine | 2010 |
Efficacy and safety of ticagrelor: a reversible P2Y12 receptor antagonist.
Topics: Acute Coronary Syndrome; Adenosine; Animals; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2010 |
Platelet pharmacogenomics.
Topics: Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Genomics; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2010 |
Clopidogrel non-responsiveness and risk of cardiovascular morbidity. An updated meta-analysis.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Resistance; Evidence-Based Medicine; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Publication Bias; Recurrence; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2010 |
Combined mechanical and pharmacological approach to a thrombus-containing lesion.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Coronary Circulation; Coronary Thrombosis; Coronary Vessels; Dilatation, Pathologic; Eptifibatide; Filtration; Humans; Male; Middle Aged; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Thrombectomy; Thrombolytic Therapy; Ticlopidine; Ultrasonography, Interventional | 2010 |
Clinical implications of clopidogrel non-response in cardiovascular patients: a systematic review and meta-analysis.
Topics: Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Poor response to clopidogrel: current and future options for its management.
Topics: Cardiovascular Diseases; Clopidogrel; Disease Management; Forecasting; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Failure | 2010 |
Relation of CYP2C19 loss-of-function polymorphism to the occurrence of stent thrombosis.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Stents; Thrombosis; Ticlopidine | 2010 |
Clopidogrel and proton pump inhibitor use: what does the evidence really say?
Topics: Clopidogrel; Drug Interactions; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
New algorithm (KAWAKAMI algorithm) to diagnose primary cutaneous vasculitis.
Topics: Adrenal Cortex Hormones; Algorithms; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytoplasmic; Clopidogrel; Cryoglobulinemia; Diagnosis, Differential; Humans; IgA Vasculitis; Immunoglobulin A; Myeloblastin; Peroxidase; Polyarteritis Nodosa; Ribonucleosides; Ticlopidine; Vasculitis, Leukocytoclastic, Cutaneous; Warfarin | 2010 |
State of the art of new P2Y12 antagonists.
Topics: Adenosine; Adenosine Monophosphate; Clopidogrel; Humans; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Quinazolinones; Receptors, Purinergic P2Y12; Sulfonamides; Thiophenes; Ticagrelor; Ticlopidine | 2010 |
Genetic causes of clopidogrel nonresponsiveness: which ones really count?
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Genotype; Humans; Metabolic Detoxication, Phase I; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prodrugs; Risk Factors; Ticlopidine | 2010 |
Drug interaction between clopidogrel and proton pump inhibitors.
Topics: Aspirin; Biomarkers; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Heart; Humans; Metabolic Detoxication, Phase I; Platelet Aggregation Inhibitors; Prodrugs; Proton Pump Inhibitors; Ticlopidine | 2010 |
Neuraxial anesthesia in obstetric patients receiving anticoagulant and antithrombotic drugs.
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Anticoagulants; Aspirin; Clopidogrel; Female; Fibrinolytic Agents; Fondaparinux; Guidelines as Topic; Hematoma, Epidural, Spinal; Heparin; Hirudins; Humans; Polysaccharides; Pregnancy; Ticlopidine; Warfarin | 2010 |
Current guidelines on antiplatelet agents for secondary prevention of noncardiogenic stroke: an evidence-based review.
Topics: American Heart Association; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; United States; Vasodilator Agents | 2010 |
Ongoing challenges in drug interaction safety: from exposure to pharmacogenomics.
Topics: Administration, Oral; Camptothecin; Clopidogrel; Drug Evaluation; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inactivation, Metabolic; Injections, Intravenous; Irinotecan; Maximum Tolerated Dose; Membrane Transport Proteins; Models, Biological; Models, Statistical; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic; Ticlopidine | 2010 |
Advances in antiplatelet therapy for stroke prevention: the new P2Y12 antagonists.
Topics: Animals; Clopidogrel; Drug Delivery Systems; Drug Design; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stroke; Ticlopidine | 2010 |
What is the risk of intensifying platelet inhibition beyond clopidogrel? A systematic review and a critical appraisal of the role of prasugrel.
Topics: Clopidogrel; Drug Evaluation, Preclinical; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Risk Factors; Thiophenes; Ticlopidine | 2010 |
Preventing serious sequelae after an acute coronary syndrome: the consequences of thrombosis versus bleeding with antiplatelet therapy.
Topics: Acute Coronary Syndrome; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Risk Factors; Thiophenes; Thrombosis; Ticlopidine | 2010 |
Antiplatelet and antithrombotic treatment of patients with peripheral arterial disease.
Topics: Administration, Oral; Aspirin; Cardiovascular Diseases; Clopidogrel; Disease Progression; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Treatment Outcome | 2010 |
Aspirin and clopidogrel resistance: should we worry about?
Topics: Aspirin; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine | 2010 |
Platelet function tests and resistance to antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2010 |
Factors associated with clopidogrel nonresponsiveness.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Coronary Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Smoking; Ticlopidine; Treatment Failure | 2010 |
Safety and efficacy of abciximab as an adjunct to percutaneous coronary intervention.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Coronary Artery Disease; Electrocardiography; Hirudins; Humans; Immunoglobulin Fab Fragments; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Recombinant Proteins; Ticlopidine | 2010 |
Modern role for clopidogrel in management of atrial fibrillation and stroke reduction.
Topics: Age Factors; Atrial Fibrillation; Clopidogrel; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2010 |
Antiplatelet therapy prasugrel: a novel platelet ADP P2Y12 receptor antagonist.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials, Phase III as Topic; Clopidogrel; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hemorrhage; Humans; Ischemia; Kidney Failure, Chronic; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2010 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1: Adding clopidogrel to standard treatment for acute myocardial infarction.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Emergency Service, Hospital; Evidence-Based Emergency Medicine; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Heterogeneity of efficacy and safety of antiplatelet therapy in cardiovascular and cerebrovascular disease.
Topics: Acute Coronary Syndrome; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine | 2010 |
Prolonged infusion of eptifibatide as bridge therapy between bare-metal stent insertion and cardiovascular surgery: case report and review of the literature.
Topics: Angioplasty; Anticoagulants; Aspirin; Cardiovascular Surgical Procedures; Clopidogrel; Coronary Artery Bypass; Eptifibatide; Hemorrhage; Humans; Male; Metals; Middle Aged; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thrombosis; Ticlopidine | 2010 |
Proton pump inhibitors and clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Evidence-Based Medicine; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Ticlopidine | 2010 |
Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis.
Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Genetic Association Studies; Genotype; Humans; Middle Aged; Polymorphism, Genetic; Recurrence; Risk Factors; Thrombosis; Ticlopidine; United States | 2011 |
Management of antiplatelet therapy during acute percutaneous coronary intervention: new strategies and therapeutics.
Topics: Adenosine; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2010 |
Proton pump inhibitors and clopidogrel: is it a significant drug interaction?
Topics: Blood Platelets; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Agents; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2010 |
The role of antiplatelet therapy in the secondary prevention of coronary artery disease.
Topics: Adenosine; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Secondary Prevention; Thiophenes; Thromboxane A2; Ticagrelor; Ticlopidine | 2010 |
Diabetes and the platelet: toward new therapeutic paradigms for diabetic atherothrombosis.
Topics: Acute Coronary Syndrome; Apoptosis; Aspirin; Blood Platelets; Clopidogrel; Diabetes Complications; Diabetes Mellitus; Glycoproteins; Humans; Models, Biological; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Thiophenes; Thromboplastin; Thrombosis; Ticlopidine | 2010 |
[Discontinuation of treatment with platelet aggregation inhibitors in surgical patients with cardiac stents].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Elective Surgical Procedures; Emergencies; Evidence-Based Medicine; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Practice Guidelines as Topic; Risk Assessment; Stents; Ticlopidine; Time Factors | 2010 |
Economy class syndrome complicated by stroke: a rare condition due to paradoxical embolism--a case report and review of the literature.
Topics: Aircraft; Anticoagulants; Aspirin; Clopidogrel; Echocardiography; Embolism, Paradoxical; Foramen Ovale, Patent; Heparin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Tomography, X-Ray Computed; Travel; Venous Thrombosis | 2011 |
[Extent of platelet aggregation inhibition and clinical events: new evidence with prasugrel].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Treatment Outcome | 2010 |
Antiplatelet therapy in percutaneous coronary intervention: recent advances in oral antiplatelet agents.
Topics: Adenosine; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Pyridines; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2010 |
Safety of proton pump inhibitors: current evidence for osteoporosis and interaction with antiplatelet agents.
Topics: Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Evidence-Based Medicine; Hip Fractures; Humans; Osteoporosis; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Therapy for ST-segment elevation myocardial infarction patients who present late or are ineligible for reperfusion therapy.
Topics: Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Clopidogrel; Comorbidity; Contraindications; Heparin, Low-Molecular-Weight; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kaplan-Meier Estimate; Myocardial Infarction; Myocardial Reperfusion; Patient Selection; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombolytic Therapy; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Acute coronary syndrome in the patient with diabetes: is the management different?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Diabetes Mellitus; Drug-Eluting Stents; Humans; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Ticlopidine | 2010 |
Aspirin and clopidogrel resistance: methodological challenges and opportunities.
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2010 |
[The role of clopidogrel in the treatment and prevention of acute coronary syndrome and repetitive atherothrombotic events].
Topics: Acute Coronary Syndrome; Clopidogrel; Embolism, Cholesterol; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 2010 |
Point-of-care testing for assessment of adequacy of oral antiplatelet therapy in patients with cardiovascular disease.
Topics: Administration, Oral; Aspirin; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Point-of-Care Systems; Ticlopidine | 2010 |
Implementing genotype-guided antithrombotic therapy.
Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Dose-Response Relationship, Drug; Genetic Privacy; Genotype; Health Policy; Humans; Mixed Function Oxygenases; Pharmacogenetics; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prasugrel Hydrochloride; Precision Medicine; Purinergic P2 Receptor Antagonists; Thiophenes; Ticlopidine; Vitamin K Epoxide Reductases; Warfarin | 2010 |
The year in interventional cardiology.
Topics: Adenosine; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Occlusion; Coronary Restenosis; Drug-Eluting Stents; Foramen Ovale, Patent; Hospital Mortality; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Radiology, Interventional; Thiophenes; Thrombolytic Therapy; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Dosing strategies for antiplatelet therapy in percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clinical Protocols; Clopidogrel; Drug Administration Schedule; Drug Monitoring; Hemorrhage; Humans; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Risk Assessment; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
What goes into a major acute coronary syndrome trial and what will future trials look like?
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clinical Trials as Topic; Clopidogrel; Cyclic N-Oxides; Eptifibatide; Heart Diseases; Humans; Peptides; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Research Design; Research Support as Topic; Risk Factors; Sample Size; Thiophenes; Ticagrelor; Ticlopidine; United Kingdom | 2010 |
Prasugrel for the treatment of acute coronary artery syndromes with percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Cost-Benefit Analysis; Humans; Models, Economic; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Quality of Life; Quality-Adjusted Life Years; Risk Assessment; Thiophenes; Ticlopidine; United Kingdom | 2010 |
Strategies and Therapies for Reducing Ischemic and Vascular Events (STRIVE): updated standing orders for ST-segment elevation myocardial infarction and unstable angina/non-ST-segment elevation myocardial infarction.
Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Contraindications; Critical Pathways; Heparin; Humans; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Thrombolytic Therapy; Ticlopidine | 2010 |
Drug-eluting stent thrombosis 1,659 days after stent deployment: case report and literature review.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Drug Administration Schedule; Drug-Eluting Stents; Electrocardiography; Humans; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Residual platelet reactivity: predicting short- and long-term clinical outcome in patients undergoing percutaneous coronary revascularization.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Secondary Prevention; Ticlopidine | 2010 |
Revaluation of clopidogrel: let the data speak for themselves.
Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2010 |
New antithrombotic agents--insights from clinical trials.
Topics: Adenosine; Anticoagulants; Aspirin; Clopidogrel; Coronary Thrombosis; Coumarins; Fibrinolytic Agents; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Thromboembolism; Ticagrelor; Ticlopidine | 2010 |
[Clopidogrel resistance--assessment of drug response and clinical significance].
Topics: Clopidogrel; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2010 |
Clopidogrel pretreatment in PCI: absolute requirement or obsolete myth?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Preoperative Care; Ticlopidine | 2011 |
Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis.
Topics: Alleles; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 Enzyme System; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Sensitivity and Specificity; Stents; Ticlopidine | 2010 |
Old and new molecular mechanisms associated with platelet resistance to antithrombotics.
Topics: Antithrombins; Aspirin; Blood Platelets; Clopidogrel; Humans; Patient Compliance; Ticlopidine | 2010 |
ACCF/AHA clopidogrel clinical alert: approaches to the FDA "boxed warning": a report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents and the American Heart Association endorsed by the Society for Cardiova
Topics: Advisory Committees; American Heart Association; Aryl Hydrocarbon Hydroxylases; Cardiology; Clopidogrel; Coronary Angiography; Cytochrome P-450 CYP2C19; Drug Labeling; Foundations; Humans; Societies, Medical; Thoracic Surgery; Ticlopidine; United States; United States Food and Drug Administration | 2010 |
Platelet P2Y₁₂ receptor inhibition: an update on clinical drug development.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Drug Design; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridines; Receptors, Purinergic P2Y12; Ticlopidine | 2010 |
[Antiplatelet therapy in coronary heart disease. Some problems and achivements].
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Resistance; Gastrointestinal Hemorrhage; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Prasugrel Hydrochloride; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Receptor, PAR-1; Thiophenes; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2010 |
Proton pump inhibitor and clopidogrel interaction: the case for watchful waiting.
Topics: Algorithms; Clopidogrel; Drug Interactions; Evidence-Based Medicine; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2010 |
Prasugrel.
Topics: Acute Coronary Syndrome; Clinical Trials as Topic; Clopidogrel; Humans; Piperazines; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Stents; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
[Platelet inhibition with prasugrel].
Topics: Acute Coronary Syndrome; Administration, Oral; Angina, Unstable; Biological Availability; Clopidogrel; Coronary Artery Disease; Humans; Metabolic Clearance Rate; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Secondary Prevention; Thiophenes; Ticlopidine | 2010 |
Safety evaluation of tirofiban.
Topics: Abciximab; Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Double-Blind Method; Drug Resistance; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Incidence; Multicenter Studies as Topic; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Thrombocytopenia; Ticlopidine; Tirofiban; Tyrosine | 2010 |
[Significance of platelet function tests].
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelet Disorders; Clopidogrel; Collagen; Hemorrhagic Disorders; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prognosis; Ristocetin; Ticlopidine | 2010 |
[Reduction of haemorrhagic risk in acute coronary syndromes].
Topics: Acute Coronary Syndrome; Anticoagulants; Aspirin; Clopidogrel; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2011 |
Pharmacologic therapy for non ST-segment elevation acute coronary syndromes: focus on antithrombotic therapy.
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Disease Management; Drug Synergism; Drug Therapy, Combination; Enoxaparin; Fibrinolytic Agents; Fondaparinux; Hemorrhage; Heparin; Hirudins; Humans; Peptide Fragments; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polysaccharides; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Recombinant Proteins; Thiophenes; Ticagrelor; Ticlopidine | 2010 |
Safety of proton pump inhibitor exposure.
Topics: Animals; Bone and Bones; Calcium; Clopidogrel; Drug Interactions; Humans; Iron; Magnesium; Neoplasms; Proton Pump Inhibitors; Ticlopidine; Vitamin B 12 | 2010 |
Controversies in oral antiplatelet therapy in patients undergoing aortocoronary bypass surgery.
Topics: Administration, Oral; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Thiophenes; Thrombosis; Ticlopidine | 2010 |
Impact of clopidogrel loading dose on clinical outcome in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Sensitivity and Specificity; Ticlopidine; Treatment Outcome | 2011 |
Controversies and future perspectives of antiplatelet therapy in secondary stroke prevention.
Topics: Aspirin; Blood-Brain Barrier; Cilostazol; Clopidogrel; Dipyridamole; Drug Interactions; Drug Therapy, Combination; Humans; Lactones; Naphthalenes; Platelet Aggregation Inhibitors; Propionates; Pyridines; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke; Succinates; Tetrazoles; Thrombosis; Ticlopidine | 2010 |
A review of the use of common antiplatelet agents in orthopaedic practice.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Orthopedics; Perioperative Care; Platelet Aggregation Inhibitors; Preoperative Care; Stents; Thrombosis; Ticlopidine | 2010 |
New P2Y12 inhibitors versus clopidogrel in percutaneous coronary intervention: a meta-analysis.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Postoperative Complications; Purinergic P2 Receptor Antagonists; Quinazolinones; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Sulfonamides; Ticlopidine | 2010 |
Clinical Inquiries: Which drugs should post-MI patients routinely receive?
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Atorvastatin; Clopidogrel; Eplerenone; Heptanoic Acids; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyrroles; Spironolactone; Ticlopidine | 2010 |
Prognostic significance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: systematic review and meta-analysis.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Humans; Intention to Treat Analysis; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Prognosis; Stents; Thrombosis; Ticlopidine | 2010 |
Nonresponders to clopidogrel: pharmacokinetics and interactions involved.
Topics: Acute Coronary Syndrome; Biotransformation; Clopidogrel; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine | 2010 |
Clopidogrel in acute coronary syndrome: implications of recent study findings.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2010 |
[Thienopyridines in the treatment and prevention of cardiovascular diseases. Part V. Combination of clopidogrel and acetylsalicylic acid in the treatment of stable patients with atherothrombotic cardiovascular diseases].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Arteriosclerosis; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Circulation; Death, Sudden, Cardiac; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors; Streptokinase; Stroke; Thrombosis; Ticlopidine; Time Factors | 2010 |
Effect of proton pump inhibitors on clinical outcome in patients treated with clopidogrel: a systematic review and meta-analysis.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Prognosis; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2010 |
A comparison of the metabolism of clopidogrel and prasugrel.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Carboxylic Ester Hydrolases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Thiophenes; Thrombosis; Ticlopidine | 2010 |
Cytochrome P450 2C19 polymorphism is associated with poor clinical outcomes in coronary artery disease patients treated with clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Humans; Myocardial Infarction; Myocardial Ischemia; Odds Ratio; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Stents; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Antithrombotic strategies in patients undergoing percutaneous coronary intervention for acute coronary syndrome.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Clopidogrel; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2010 |
Regulators of platelet cAMP levels: clinical and therapeutic implications.
Topics: Blood Platelets; Clopidogrel; Cyclic AMP; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Receptors, Vasoactive Intestinal Polypeptide, Type I; Signal Transduction; Ticlopidine | 2010 |
Prasugrel as antiplatelet therapy in patients with acute coronary syndromes or undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Humans; Piperazines; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2010 |
[New aspects on "triple therapy" after coronary stent implantation].
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk Factors; Stents; Stroke; Thrombosis; Ticlopidine; Vitamin K | 2010 |
Aspirin and antiplatelet agent resistance: implications for prevention of secondary stroke.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2010 |
Review article: combination of clopidogrel and proton pump inhibitors: implications for clinicians.
Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Humans; Myocardial Infarction; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2010 |
Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variability.
Topics: Animals; Biological Availability; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2010 |
NSAID-induced gastrointestinal and cardiovascular injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 2 Inhibitors; Drug Interactions; Gastrointestinal Diseases; Histamine H2 Antagonists; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Ticlopidine | 2010 |
Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke.
Topics: Administration, Oral; Anticoagulants; Clopidogrel; Dipyridamole; Humans; Intestinal Absorption; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Warfarin | 2010 |
Prevention of the renarrowing of coronary arteries using drug-eluting stents in the perioperative period: an update.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Coronary Vessels; Drug-Eluting Stents; Humans; Myocardial Revascularization; Perioperative Care; Perioperative Period; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2010 |
Individual variability in the disposition of and response to clopidogrel: pharmacogenomics and beyond.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Evaluation; Humans; Individuality; Pharmacogenetics; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Treatment Outcome | 2011 |
Clopidogrel pharmacogenomics: next steps: a clinical algorithm, gene-gene interactions, and an elusive outcomes trial.
Topics: Algorithms; Biotransformation; Clinical Trials as Topic; Clopidogrel; Drug Labeling; Evidence-Based Medicine; Genetic Testing; Genotype; Humans; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Precision Medicine; Risk Assessment; Ticlopidine; United States; United States Food and Drug Administration | 2010 |
The platelet P2Y₁₂ receptor for adenosine diphosphate: congenital and drug-induced defects.
Topics: Adenosine; Adenosine Diphosphate; Animals; Blood Platelet Disorders; Blood Platelets; Clopidogrel; Female; Hemorrhage; Humans; Male; Mice; Mutation; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Risk; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
[Dilemma between gastroprotection and cardiovascular prevention].
Topics: Alleles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Long-Term Care; Mutation; Omeprazole; Peptic Ulcer Hemorrhage; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Survival Analysis; Ticlopidine; Treatment Outcome | 2010 |
Personalized approaches to clopidogrel therapy: are we there yet?
Topics: Aryl Hydrocarbon Hydroxylases; Blood Coagulation; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine | 2010 |
Implications of pharmacogenetic testing for patients taking warfarin or clopidogrel.
Topics: Anticoagulants; Clopidogrel; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Genome-Wide Association Study; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome; Warfarin | 2011 |
Effects of proton pump inhibitors on adverse gastrointestinal events in patients receiving clopidogrel: systematic review and meta-analysis.
Topics: Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Diseases; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Oral antiplatelet therapy in stroke prevention. Minireview.
Topics: Administration, Oral; Aspirin; Clopidogrel; Dipyridamole; Drug Combinations; Humans; Ischemic Attack, Transient; Isoindoles; Phenylbutyrates; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2010 |
[Clinical impact and underlying mechanism of clopidogrel response variability].
Topics: Clopidogrel; Genetic Variation; Humans; Ticlopidine | 2010 |
Ticagrelor: an investigational oral antiplatelet treatment for reduction of major adverse cardiac events in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Blood Platelets; Clopidogrel; Dyspnea; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Aspirin; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Thienopyridines; Thiophenes; Ticlopidine | 2010 |
[New era in antiplatelet therapy based on results from recent clinical trials].
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2011 |
The safety of clopidogrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2011 |
Drug-drug interactions that reduce the formation of pharmacologically active metabolites: a poorly understood problem in clinical practice.
Topics: Analgesics, Opioid; Angiotensin II Type 1 Receptor Blockers; Antineoplastic Agents, Hormonal; Biotransformation; Clopidogrel; Codeine; Drug Interactions; Humans; Losartan; Platelet Aggregation Inhibitors; Tamoxifen; Ticlopidine | 2010 |
Controversy of proton pump inhibitor and clopidogrel interaction: a review.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Stomach Ulcer; Ticlopidine | 2010 |
Clopidogrel withdrawal: is there a "rebound" phenomenon?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Humans; Patient Selection; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Current status of antiplatelet agents to prevent stroke.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Secondary Prevention; Stroke; Ticlopidine | 2011 |
Inhibition of the antithrombotic effects of clopidogrel by proton pump inhibitors: facts or fancies?
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2010 |
Outcomes of patients receiving clopidogrel prior to cardiac surgery.
Topics: Cardiac Surgical Procedures; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Preoperative Care; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2012 |
[Antithrombotic therapy in patients with prosthetic heart valves].
Topics: Anticoagulants; Aspirin; Blood Coagulation Tests; Clopidogrel; Drug Monitoring; Heart Valve Diseases; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Hemorrhage; Humans; Monitoring, Physiologic; Platelet Aggregation Inhibitors; Prognosis; Thromboembolism; Ticlopidine; Warfarin | 2010 |
[Efficacy and safety of various doses of acetylsalicylic Acid in prevention of complications of atherothrombosis].
Topics: Aspirin; Blood Platelets; Blood Vessels; Cardiovascular Diseases; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Dose-Response Relationship, Drug; Drug Dosage Calculations; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Assessment; Secondary Prevention; Stomach Ulcer; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Prasugrel: an efficacy and safety review of a new antiplatelet therapy option.
Topics: Acute Coronary Syndrome; American Heart Association; Angioplasty, Balloon, Coronary; Clinical Trials, Phase III as Topic; Clopidogrel; Hemorrhage; Humans; Patient Selection; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Assessment; Thiophenes; Ticlopidine; Treatment Outcome; United States | 2010 |
Contemporary management of coronary heart disease.
Topics: Acute Coronary Syndrome; Administration, Oral; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Disease; Electrocardiography; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Agonists; Randomized Controlled Trials as Topic; Registries; Secondary Prevention; Ticlopidine; Time Factors; United Kingdom | 2010 |
ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Aspirin; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Thienopyridines; Thiophenes; Ticlopidine | 2010 |
The potential interaction between clopidogrel and proton pump inhibitors: a systematic review.
Topics: Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Ticagrelor: a novel oral antiplatelet agent.
Topics: Adenosine; Administration, Oral; Aged; Clopidogrel; Drug Approval; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2010 |
Ticagrelor: from discovery to Phase III clinical trial.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Clinical Trials, Phase III as Topic; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2010 |
Prasugrel for the treatment of coronary thrombosis: a review of pharmacological properties, indications for use and future development.
Topics: Animals; Clopidogrel; Coronary Thrombosis; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2011 |
The role of the cytochrome P450 polymorphisms in clopidogrel efficacy and clinical utility.
Topics: Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 Enzyme System; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2011 |
Platelet function testing in clinical diagnostics.
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Hemorrhage; Humans; Intracranial Embolism; Intracranial Thrombosis; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Ticlopidine | 2011 |
[New approaches and indications for the analysis of platelet function in cardiology].
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Interactions; Hemorrhage; Humans; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
[Interaction between clopidogrel and proton pump inhibitors].
Topics: Clopidogrel; Drug Interactions; Humans; Proton Pump Inhibitors; Ticlopidine | 2010 |
Safety and efficacy of triple antithrombotic therapy after percutaneous coronary intervention in patients needing long-term anticoagulation.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Patient Selection; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2011 |
Meta-analysis of the combination of warfarin and dual antiplatelet therapy after coronary stenting in patients with indications for chronic oral anticoagulation.
Topics: Administration, Oral; Anticoagulants; Aspirin; Chronic Disease; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome; Warfarin | 2011 |
Management of type-2 diabetes with anti-platelet therapies: special reference to aspirin.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 2; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Thienopyridines; Ticlopidine; Vascular Diseases | 2011 |
Proton pump inhibitor side effects and drug interactions: much ado about nothing?
Topics: Anemia, Iron-Deficiency; Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Fractures, Spontaneous; Gastroesophageal Reflux; Humans; Nephritis; Osteoporosis; Peptic Ulcer; Platelet Aggregation Inhibitors; Pneumonia; Proton Pump Inhibitors; Risk Factors; Ticlopidine; Vitamin B Deficiency | 2011 |
[Novel agents in antiplatelet therapy].
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Aspirin; Clopidogrel; Humans; Lactones; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Pyridines; Receptors, Thrombin; Thiophenes; Ticagrelor; Ticlopidine | 2010 |
The role of antithrombotics in secondary stroke prevention.
Topics: Anticoagulants; Clopidogrel; Cyclooxygenase Inhibitors; Fibrinolytic Agents; Humans; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2010 |
[Impact of genetic polymorphisms in the clinical response of oral inhibitors of the platelet P2Y12 adenosine diphosphate (ADP) receptor].
Topics: Administration, Oral; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2010 |
Antiplatelet therapy in the perioperative period.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Evidence-Based Medicine; Hemorrhage; Humans; Perioperative Period; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2011 |
Clopidogrel and proton pump inhibitors: a clinically meaningful interaction?
Topics: Clopidogrel; Drug Interactions; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Ticlopidine | 2011 |
Beyond efficacy: pharmacokinetic differences between clopidogrel, prasugrel and ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Standard of Care; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
Clopidogrel 150 vs. 75 mg day(-1) in patients undergoing percutaneous coronary intervention: a meta-analysis.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Patients with drug-eluting stents and management of their anticoagulant therapy in cutaneous surgery.
Topics: Anticoagulants; Aspirin; Clopidogrel; Dermatologic Surgical Procedures; Drug-Eluting Stents; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2011 |
Gastrointestinal bleeding after percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Intestines; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2011 |
The onset of inhibition of platelet aggregation with prasugrel compared with clopidogrel loading doses using gatekeeping analysis of integrated clinical pharmacology data.
Topics: Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Humans; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Time Factors | 2011 |
[Clopidogrel--proton pump inhibitors drug interaction: implications to clinical practice].
Topics: Clopidogrel; Drug Interactions; Gastrointestinal Diseases; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Antiplatelet therapy in the perioperative period.
Topics: Aspirin; Clopidogrel; Humans; Perioperative Period; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2010 |
[Coronary heart disease - what is of importance after coronary intervention?].
Topics: Adenosine; Aftercare; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Disease; Drug Administration Schedule; Drug Approval; Drug Therapy, Combination; Drug-Eluting Stents; Gastrointestinal Hemorrhage; Humans; Myocardial Revascularization; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Proton Pump Inhibitors; Stents; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
"Triple therapy" rather than "triple threat": a meta-analysis of the two antithrombotic regimens after stent implantation in patients receiving long-term oral anticoagulant treatment.
Topics: Administration, Oral; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Stents; Stroke; Thromboembolism; Ticlopidine; Warfarin | 2011 |
Pharmacokinetics, drug metabolism, and safety of prasugrel and clopidogrel.
Topics: Area Under Curve; Clopidogrel; Drug Interactions; Half-Life; Humans; Metabolic Clearance Rate; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2011 |
Review article: proton pump inhibitors with clopidogrel--evidence for and against a clinically-important interaction.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk; Ticlopidine | 2011 |
Thienopyridines in Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Clopidogrel; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thienopyridines; Ticlopidine | 2011 |
Antiplatelet resistance in stroke.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk; Secondary Prevention; Stroke; Ticlopidine | 2011 |
Platelet function and antiplatelet therapy in cardiovascular disease: implications of genetic polymorphisms.
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Genetic Variation; Genotype; Haplotypes; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Ticlopidine | 2011 |
Antiplatelet agents in cardiovascular disease.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Time Factors; United States | 2011 |
Variability in response to clopidogrel: how important are pharmacogenetics and drug interactions?
Topics: Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine | 2011 |
Antiplatelet therapy after placement of a drug-eluting stent: a review of efficacy and safety studies.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
[Current options to manage clopidogrel poor responsiveness].
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Interactions; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Monitoring the effectiveness of antiplatelet therapy: opportunities and limitations.
Topics: Aspirin; Clopidogrel; Drug Monitoring; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Triple therapy in hospitalized patients: facts and controversies.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Hospitalization; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Warfarin | 2011 |
The antithrombotic management of patients on oral anticoagulation undergoing coronary stent implantation: an update.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Risk; Ticlopidine; Warfarin | 2012 |
[Strategy to manage low dose aspirin-induced gastrointestinal injury].
Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Famotidine; Gastric Mucosa; Humans; Omeprazole; Peptic Ulcer; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Proton Pump Inhibitors; Ticlopidine | 2011 |
Is prasugrel more effective than clopidogrel at preventing future cardiac events?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2011 |
Clopidogrel-drug interactions.
Topics: Animals; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Polypharmacy; Proton Pump Inhibitors; Ticlopidine | 2011 |
[ST-elevation myocardial infarction: reperfusion strategy based on the results from large clinical trials].
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Fibrinolytic Agents; Guidelines as Topic; Heparin; Humans; Meta-Analysis as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Quality of Life; Randomized Controlled Trials as Topic; Thrombolytic Therapy; Ticlopidine; Time Factors | 2010 |
Genomics and drug response.
Topics: Anti-Infective Agents; Antineoplastic Agents; Aromatase Inhibitors; Cardiovascular Agents; Clopidogrel; Genome-Wide Association Study; Genomics; Genotype; Humans; Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Ticlopidine; Warfarin | 2011 |
[Prasugrel for acute and long-term treatment of patients with acute coronary syndromes: what is state-of-the-art?].
Topics: Acute Coronary Syndrome; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2011 |
[Prodrug technology in the development of medicinal agents].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aspirin; Clopidogrel; Drug Delivery Systems; Drug Design; Humans; Lansoprazole; Oseltamivir; Prodrugs; Simvastatin; Ticlopidine | 2011 |
Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others.
Topics: Clopidogrel; Cytochrome P-450 Enzyme System; Genetic Testing; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pharmacogenetics; Psychotropic Drugs; Tamoxifen; Ticlopidine; Warfarin | 2011 |
Triple therapy: boon or bane for high-risk CV patients?
Topics: Acute Coronary Syndrome; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Warfarin | 2011 |
Clopidogrel in acute coronary syndromes: where are we now?
Topics: Acute Coronary Syndrome; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Clinical Protocols; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Platelet Activation; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Survival Analysis; Ticlopidine; Treatment Outcome | 2011 |
Genetic variability in response to clopidogrel therapy and its clinical implications.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; DNA Mutational Analysis; Genetic Variation; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Predictive Value of Tests; Ticlopidine | 2011 |
Bleeding manifestations of congenital and drug-induced defects of the platelet P2Y12 receptor for adenosine diphosphate.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Clinical Trials, Phase III as Topic; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Quinazolinones; Receptors, Purinergic P2Y12; Sulfonamides; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors.
Topics: Adenosine; Adenosine Monophosphate; Animals; Clinical Trials, Phase III as Topic; Clopidogrel; Humans; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Protein Binding; Purinergic P2Y Receptor Antagonists; Quinazolinones; Sulfonamides; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2011 |
Secondary prevention in the acute and early chronic phase after ischaemic stroke and transient ischaemic attacks with antiplatelet drugs--is antiplatelet monotherapy still reasonable?
Topics: Abciximab; Acute Disease; Antibodies, Monoclonal; Aspirin; Chronic Disease; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Combinations; Humans; Immunoglobulin Fab Fragments; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2011 |
Platelet function variability and non-genetic causes.
Topics: Blood Platelets; Clinical Trials as Topic; Clopidogrel; Comorbidity; Coronary Artery Disease; Diabetes Mellitus; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
High platelet reactivity and clinical outcome - fact and fiction.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Variation; Humans; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Proton pump inhibitors in rheumatic diseases: clinical practice, drug interactions, bone fractures and risk of infections.
Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Aspirin; Calcium, Dietary; Clopidogrel; Clostridioides difficile; Comorbidity; Cytochrome P-450 CYP2C19; Disease Susceptibility; Drug Interactions; Enterocolitis, Pseudomembranous; Fractures, Spontaneous; Gastrointestinal Hemorrhage; Humans; Hyperparathyroidism, Secondary; Infections; Osteoporosis; Proton Pump Inhibitors; Rheumatic Diseases; Risk; Thrombophilia; Ticlopidine | 2011 |
Clopidogrel and proton pump inhibitors: influence of pharmacological interactions on clinical outcomes and mechanistic explanations.
Topics: Animals; Biotransformation; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Evidence-Based Medicine; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Practice Guidelines as Topic; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2011 |
[Myocardial infarction: Role of new antiplatelet agents].
Topics: Adenosine; Adenosine Monophosphate; Administration, Oral; Clinical Trials as Topic; Clopidogrel; Combined Modality Therapy; Disease Management; Drug Resistance; Fibrinolytic Agents; Hemorrhage; Humans; Injections, Intravenous; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Reperfusion; Myocardial Revascularization; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticagrelor; Ticlopidine; Time Factors | 2011 |
Proton pump inhibitors, genetic polymorphisms and response to clopidogrel therapy.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Interactions; Enzyme Activation; Genetic Testing; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Postoperative Complications; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Incurred sample reanalysis (ISR): a decisive tool in bioanalytical research.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Artifacts; Biological Assay; Clopidogrel; Drug Stability; Guidelines as Topic; Humans; Hydrochlorothiazide; Hydrogen-Ion Concentration; Mesalamine; Piperazines; Problem Solving; Purines; Quality Control; Rabeprazole; Reference Standards; Reproducibility of Results; Sildenafil Citrate; Specimen Handling; Sulfones; Ticlopidine; Validation Studies as Topic | 2011 |
The influence of CYP2C19 polymorphisms on the pharmacokinetics, pharmacodynamics, and clinical effectiveness of P2Y(12) inhibitors.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Genotype; Humans; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2011 |
Review and management of side effects associated with antiplatelet therapy for prevention of recurrent cerebrovascular events.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Headache; Hemorrhage; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Stroke; Ticlopidine | 2011 |
[What has the long clinical experience of PPIs taught us about their putative side effects?].
Topics: Bone Density; Clopidogrel; Drug Interactions; Gastric Mucosa; Humans; Infections; Minerals; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine; Vitamins | 2011 |
Interactions between clopidogrel and proton pump inhibitors: a review of evidence.
Topics: Clopidogrel; Drug Interactions; Drug Resistance; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2011 |
Early clopidogrel use in non-ST elevation acute coronary syndrome and subsequent coronary artery bypass grafting.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Ischaemic and bleeding complications with new, compared to standard, ADP-antagonist regimens in acute coronary syndromes: a meta-analysis of randomized trials.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Clopidogrel; Hemorrhage; Humans; Ischemia; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
[Recent advances on the studies of the platelet's inhibition and aggregation. State of the art of new P2Y12 antagonists].
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Catheter Ablation; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Humans; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
Antithrombotic management for transient ischemic attack and ischemic stroke (other than atrial fibrillation).
Topics: Adenosine; Aryl Hydrocarbon Hydroxylases; Brain Ischemia; Cilostazol; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Fibrinolytic Agents; Foramen Ovale, Patent; Genotype; Humans; Ischemic Attack, Transient; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Risk Assessment; Risk Factors; Stroke; Tetrazoles; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
P2Y receptors in health and disease.
Topics: Animals; Aspirin; Clopidogrel; Disease; Health; Humans; Platelet Activation; Receptors, Purinergic P2Y; Ticlopidine | 2011 |
Pharmacogenomics of clopidogrel: evidence and perspectives.
Topics: Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Evidence-Based Medicine; Genotype; Humans; Patient Selection; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Risk Assessment; Risk Factors; Ticlopidine | 2011 |
Personalized antiplatelet therapy: review of the latest clinical evidence.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Cytochrome P-450 CYP2C19; Drug Resistance; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Primary Prevention; Stents; Ticlopidine | 2011 |
Beyond aspirin and clopidogrel: is there a need for additional antiplatelet therapy in ACS?
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Quinazolinones; Receptors, Purinergic P2Y12; Sulfonamides; Tetrazoles; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
Safety of clopidogrel being continued until the time of coronary artery bypass grafting in patients with acute coronary syndrome: a meta-analysis of 34 studies.
Topics: Acute Coronary Syndrome; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Critical Care; Female; Hemorrhage; Humans; Length of Stay; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Reoperation; Research Design; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2011 |
Clinical, genetic and confounding factors determine the dynamics of the in vitro response/non response to clopidogrel.
Topics: Adenosine Diphosphate; Clopidogrel; Drug Interactions; Drug Resistance; Female; Humans; In Vitro Techniques; Male; Pharmacogenetics; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2011 |
Population pharmacokinetic/pharmacodynamic modeling of clopidogrel in Korean healthy volunteers and stroke patients.
Topics: Adult; Aged; Aged, 80 and over; Asian People; Clinical Trials as Topic; Clopidogrel; Humans; Male; Middle Aged; Models, Biological; Nonlinear Dynamics; Platelet Aggregation Inhibitors; Republic of Korea; Stroke; Ticlopidine; Young Adult | 2012 |
Implications of variability in definition and reporting of major bleeding in randomized trials of oral P2Y12 inhibitors for acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials, Phase III as Topic; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
Genetic determinants of on-clopidogrel high platelet reactivity.
Topics: Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Aspirin; ATP Binding Cassette Transporter, Subfamily B; Biomarkers, Pharmacological; Blood Platelets; Clopidogrel; Drug Combinations; Genetic Testing; Humans; Liver; Mutation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prodrugs; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Antiplatelet drug therapy: role of pharmacodynamic and genetic testing.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2011 |
Recent developments in the use of antiplatelet agents to prevent cardiovascular events.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Fibrinolytic Agents; Genetic Predisposition to Disease; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine | 2011 |
[New platelet P2Y12 inhibitors versus clopidogrel in percutaneous coronary interventions. a meta-analysis].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Myocardial Ischemia; Platelet Aggregation; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2011 |
Ticagrelor for acute coronary syndrome?
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Contraindications; Drug Costs; Humans; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
Emerging antiplatelet therapies in percutaneous coronary intervention: a focus on prasugrel.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Hemorrhage; Humans; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2011 |
Clopidogrel hydrogen sulphate for atrial fibrillation.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Thrombosis; Ticlopidine | 2011 |
Meta-analyses of the association between cytochrome CYP2C19 loss- and gain-of-function polymorphisms and cardiovascular outcomes in patients with coronary artery disease treated with clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Genotype; Hemorrhage; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Ticlopidine | 2012 |
Benefits and risks of using clopidogrel before coronary artery bypass surgery: systematic review and meta-analysis of randomized trials and observational studies.
Topics: Blood Transfusion; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Drug Administration Schedule; Evidence-Based Medicine; Hemorrhage; Humans; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Reoperation; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Genetic determinants of platelet response to clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prognosis; Ticlopidine | 2011 |
Clopidogrel response variability and the advent of personalised antiplatelet therapy. A bench to bedside journey.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Humans; In Vitro Techniques; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Precision Medicine; Prospective Studies; Receptors, Purinergic P2Y12; Risk Factors; Signal Transduction; Stents; Thrombosis; Ticlopidine; Translational Research, Biomedical | 2011 |
[ADP receptor blockers: new insights in the therapy and prophylaxis of ischemic heart disease].
Topics: Acute Coronary Syndrome; Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Pyridines; Receptors, Purinergic P2; Stents; Ticlopidine | 2011 |
Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy.
Topics: Acute Coronary Syndrome; Alleles; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Clopidogrel with proton pump inhibitors: safe or not?
Topics: Cardiovascular Diseases; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Ticlopidine | 2011 |
Progress of antiplatelet pharmacogenomics.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Translational Research, Biomedical | 2011 |
Role of platelet function testing in clinical practice: current concepts and future perspectives.
Topics: Acute Coronary Syndrome; Biotransformation; Brain Ischemia; Clopidogrel; Drug Monitoring; Drug Resistance; Humans; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk; Ticlopidine | 2011 |
Does CYP2C19 inhibition lead to clopidogrel thrombogenicity?
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Combinations; Drug Interactions; Humans; Proton Pump Inhibitors; Thrombosis; Ticlopidine | 2011 |
[Interaction between clopidogrel and proton pump inhibitors].
Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Anticipating and managing bleeding complications in patients with coronary stents who are receiving dual antiplatelet treatment.
Topics: Blood Component Transfusion; Catheters, Indwelling; Clopidogrel; Coagulants; Coronary Artery Disease; Coronary Restenosis; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Endoscopy, Gastrointestinal; Fibrinolytic Agents; Forecasting; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Intracranial Hemorrhages; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2011 |
Prasugrel resistance: fact or fiction.
Topics: Blood Platelets; Clopidogrel; Drug Resistance; Humans; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2012 |
The genetic basis of platelet responsiveness to clopidogrel. A critical review of the literature.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2011 |
Association of genetic variants in CYP2C19 and adverse clinical outcomes after treatment with clopidogrel: an updated meta-analysis.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Prasugrel vs. ticagrelor in acute coronary syndromes: which one to choose?
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Survival Rate; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
Genotypic and phenotypic assessment of platelet function and response to P2Y12 antagonists.
Topics: Adenosine; Clopidogrel; Coronary Artery Disease; Female; Genetic Association Studies; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
Systematic review of thienopyridine discontinuation and its impact upon clinical outcomes.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Drug-Eluting Stents; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
[Ticagrelor: a novel antiplatelet agent for patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Drug Interactions; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2011 |
Laboratory evaluation of clopidogrel responsiveness by platelet function and genetic methods.
Topics: Aryl Hydrocarbon Hydroxylases; Biological Availability; Biotransformation; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Monitoring; Genotyping Techniques; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Prodrugs; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2011 |
Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis.
Topics: Acute Coronary Syndrome; Angina Pectoris; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Genotype; Humans; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Assessment; Selection Bias; Thromboembolism; Ticlopidine; Treatment Outcome | 2011 |
Clopidogrel pharmacogenetics: metabolism and drug interactions.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2011 |
Thienopyridine-associated drug-drug interactions: pharmacologic mechanisms and clinical relevance.
Topics: Clopidogrel; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Pyridines; Ticlopidine | 2011 |
Antiplatelet function variability in clopidogrel-treated patients: need for new antiplatelet agents.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Design; Drug Interactions; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2; Ticlopidine | 2012 |
Statins for acute ischemic stroke.
Topics: Atorvastatin; Cause of Death; Clopidogrel; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Neuroprotective Agents; Platelet Aggregation Inhibitors; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Stroke; Ticlopidine | 2011 |
Clopidogrel treatment during pregnancy: a case report and a review of literature.
Topics: Adult; Clopidogrel; Female; Humans; Infant, Newborn; Myocardial Ischemia; Pregnancy; Pregnancy Complications, Cardiovascular; Ticlopidine; Treatment Outcome | 2011 |
The future of platelet function testing to guide therapy in clopidogrel low and enhanced responders.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2011 |
New insights in antiplatelet therapy for patients with ischemic stroke.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Dipyridamole; Dose-Response Relationship, Drug; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2011 |
Clopidogrel resistance: identifying and overcoming a barrier to effective antiplatelet treatment.
Topics: Animals; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Failure | 2011 |
A meta-analysis of impact of proton pump inhibitors on antiplatelet effect of clopidogrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Data Interpretation, Statistical; Drug Interactions; Endpoint Determination; Humans; Myocardial Infarction; Odds Ratio; Patient Readmission; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2012 |
Clopidogrel "resistance": where are we now?
Topics: Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Drug Substitution; Hemorrhage; Humans; Medication Adherence; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Risk Factors; Thrombosis; Ticlopidine; Treatment Failure | 2013 |
Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (review of Technology Appraisal No. 90): a systematic review and economic analysis.
Topics: Arterial Occlusive Diseases; Aspirin; Brain Ischemia; Clopidogrel; Cost-Benefit Analysis; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Humans; Models, Economic; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Ticlopidine | 2011 |
Clinical effects and outcomes with new P2Y12 inhibitors in ACS.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Drug Design; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thienopyridines; Ticlopidine | 2012 |
[Resistance to antiplatelet drugs in patients with cerebrovascular disorders].
Topics: Arachidonate Lipoxygenases; Aspirin; Biotransformation; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Humans; Intracranial Thrombosis; Patient Compliance; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Secondary Prevention; Ticlopidine | 2011 |
Treating acute coronary syndromes with new antiplatelet drugs: the mortality issue with prasugrel and ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Angiography; Diabetes Mellitus; Female; Humans; Hypertension; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
[New clinical concept and therapeutic strategy for TIA].
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Diffusion Magnetic Resonance Imaging; Humans; Ischemic Attack, Transient; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk; Secondary Prevention; Stroke; Tetrazoles; Ticlopidine; Time Factors | 2010 |
Variability of clopidogrel response in patients with type 2 diabetes mellitus.
Topics: Clopidogrel; Coronary Artery Disease; Diabetes Complications; Diabetes Mellitus, Type 2; Drug Monitoring; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2011 |
The interaction between proton pump inhibitors and clopidogrel and upper gastrointestinal bleeding.
Topics: Cardiovascular Diseases; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine; Upper Gastrointestinal Tract | 2011 |
Platelet function monitoring in patients on clopidogrel: What should we learn from GRAVITAS?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Humans; Monitoring, Physiologic; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2012 |
Anti-thrombotic medications for the neurointerventionist: aspirin and clopidogrel.
Topics: Aspirin; Clopidogrel; Fibrinolytic Agents; Humans; Nervous System Diseases; Neuroprotective Agents; Ticlopidine | 2010 |
High on treatment platelet reactivity.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Humans; Myocardial Ischemia; Platelet Activation; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Prescribing proton pump inhibitor and clopidogrel together: current state of recommendations.
Topics: Clopidogrel; Drug Interactions; Drug Prescriptions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2011 |
Current evidence for genetic testing in clopidogrel-treated patients undergoing coronary stenting.
Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers, Pharmacological; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2011 |
[Clopidogrel and stroke].
Topics: Acute Disease; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Inflammation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stroke; Ticlopidine | 2011 |
Antiplatelet therapy in the era of percutaneous coronary intervention with drug-eluting balloons.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coated Materials, Biocompatible; Coronary Artery Disease; Coronary Restenosis; Drug Delivery Systems; Drug Therapy, Combination; Equipment Design; Evidence-Based Medicine; Humans; Patient Selection; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Impact of platelet reactivity on clinical outcomes after percutaneous coronary intervention. A collaborative meta-analysis of individual participant data.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine | 2011 |
Anti-Platelet Therapy for Acute Coronary Syndrome: A Review of Currently Available Agents and What the Future Holds.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
[Decreasing incidence of stent thrombosis].
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Immunoglobulin Fab Fragments; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Recurrence; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome; Ventricular Dysfunction, Left | 2011 |
Antiplatelet options for secondary prevention in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Risk Factors; Secondary Prevention; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
[Current coagulation diagnostics in intensive care medicine].
Topics: Anticoagulants; Aspirin; Blood Coagulation Tests; Clopidogrel; Cost-Benefit Analysis; Early Diagnosis; Fibrinolysis; Germany; Hemorrhagic Disorders; Humans; Partial Thromboplastin Time; Platelet Aggregation; Postoperative Hemorrhage; Predictive Value of Tests; Preoperative Care; Prothrombin Time; Thrombelastography; Ticlopidine | 2011 |
Latest clinical data on testing for high on-treatment platelet reactivity.
Topics: Cardiovascular Diseases; Clopidogrel; Drug Monitoring; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2011 |
Clopidogrel and PPI interaction: clinically relevant or not?
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Thienopyridines; Ticlopidine | 2012 |
Safety and efficacy of antiplatelet and antithrombotic therapy in acute coronary syndrome patients with chronic kidney disease.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Chronic Disease; Clinical Trials as Topic; Clopidogrel; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Fibrinolytic Agents; Fondaparinux; Hemorrhage; Heparin; Hirudins; Humans; Kidney Diseases; Peptide Fragments; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polysaccharides; Prasugrel Hydrochloride; Recombinant Proteins; Thiophenes; Ticagrelor; Ticlopidine; Uremia | 2011 |
Evaluating the risk-benefit profile of the direct-acting P2Y(12) inhibitor ticagrelor in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Cost-Benefit Analysis; Drug Interactions; Genotype; Humans; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Assessment; Ticagrelor; Ticlopidine | 2011 |
Antiplatelets in secondary stroke prevention: should clopidogrel be the first choice?
Topics: Aspirin; Clopidogrel; Dipyridamole; Humans; Ischemia; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2012 |
The gain-of-function variant allele CYP2C19*17: a double-edged sword between thrombosis and bleeding in clopidogrel-treated patients.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Predisposition to Disease; Genetic Variation; Hemorrhage; Humans; Odds Ratio; Phenotype; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Unravelling the benefit against the risk of long-term dual antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Responsiveness to P2Y12 receptor inhibitors.
Topics: Clopidogrel; Drug Resistance; Humans; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2011 |
Medical groups, researchers fine-tune clopidogrel therapy.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Randomized Controlled Trials as Topic; Ticlopidine | 2011 |
The clinical relevance of response variability to antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Antiplatelet agents and anticoagulants for hypertension.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Humans; Hypertension; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thromboembolism; Ticlopidine; Warfarin | 2011 |
[Clopidogrel resistance--clinical significance, pathogenesis and potential solutions].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Prevalence; Thrombosis; Ticlopidine | 2011 |
Clopidogrel and proton pump inhibitors: is there a significant drug-drug interaction?
Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Pharmacogenetics of drug-metabolizing enzymes: the prodrug hypothesis.
Topics: Aryl Hydrocarbon Hydroxylases; Azathioprine; Camptothecin; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Enzymes; Glucuronosyltransferase; Humans; Inactivation, Metabolic; Irinotecan; Methyltransferases; Mixed Function Oxygenases; Prodrugs; Tamoxifen; Ticlopidine; Vitamin K Epoxide Reductases; Warfarin | 2012 |
Antiplatelet therapy in patients with ST-elevation myocardial infarction undergoing myocardial revascularisation: beyond clopidogrel.
Topics: Adenosine; Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Myocardial Revascularization; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Antiplatelet therapy in ENT surgery: a review.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Decision Making; Drug-Eluting Stents; Humans; Otorhinolaryngologic Surgical Procedures; Perioperative Care; Platelet Aggregation Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2012 |
P2Y12 platelet inhibition in clinical practice.
Topics: Adenosine; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Platelet-mediated thrombosis and drug-eluting stents.
Topics: Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Equipment Design; Humans; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Thiophenes; Ticlopidine | 2011 |
Lack of significant interactions between clopidogrel and proton pump inhibitor therapy: meta-analysis of existing literature.
Topics: Cardiovascular Diseases; Clopidogrel; Death; Drug Interactions; Drug Therapy, Combination; Humans; Outcome and Process Assessment, Health Care; Patient Readmission; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Adjustment; Risk Assessment; Ticlopidine | 2012 |
CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Randomized Controlled Trials as Topic; Risk; Thrombosis; Ticlopidine | 2011 |
Effects of proton pump inhibitors on platelet function in patients receiving clopidogrel: a systematic review.
Topics: Blood Platelets; Clopidogrel; Drug Interactions; Esomeprazole; Humans; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2012 |
Unstable angina and non-ST elevation myocardial infarction.
Topics: Acute Coronary Syndrome; Adenosine; Angina, Unstable; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Echocardiography; Electrocardiography; Humans; Myocardial Infarction; Myocardial Revascularization; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Recent advances in the pharmacogenetics of clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Genotype; Humans; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2012 |
ABCB1 C3435T polymorphism and risk of adverse clinical events in clopidogrel treated patients: a meta-analysis.
Topics: Acute Coronary Syndrome; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Female; Humans; Male; Middle Aged; Polymorphism, Genetic; Prognosis; Risk Factors; Ticlopidine | 2012 |
A comprehensive comparative review of adenosine diphosphate receptor antagonists.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Drug Interactions; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
InforMatrix: ADP antagonists in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Cost-Benefit Analysis; Decision Support Techniques; Drug Costs; Drug Information Services; Drugs, Generic; Evidence-Based Medicine; Humans; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Assessment; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Response variability to clopidogrel: is tailored treatment, based on laboratory testing, the right solution?
Topics: Blood Platelets; Clopidogrel; Drug Resistance; Evidence-Based Medicine; Humans; Patient Selection; Platelet Aggregation Inhibitors; Platelet Function Tests; Practice Guidelines as Topic; Precision Medicine; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Failure | 2012 |
Recent safety concerns with proton pump inhibitors.
Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Fractures, Spontaneous; Gastrointestinal Hemorrhage; Humans; Hypercalciuria; Nephrocalcinosis; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Renal Tubular Transport, Inborn Errors; Risk Factors; Ticlopidine; Treatment Outcome | 2012 |
Options to overcome clopidogrel response variability.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Quantitative comparison of clopidogrel 600 mg, prasugrel and ticagrelor, against clopidogrel 300 mg on major adverse cardiovascular events and bleeding in coronary stenting: synthesis of CURRENT-OASIS-7, TRITON-TIMI-38 and PLATO.
Topics: Adenosine; Animals; Cardiovascular Diseases; Clopidogrel; Hemorrhage; Humans; Piperazines; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Prevalence of poor biological response to clopidogrel: a systematic review.
Topics: Clopidogrel; Humans; Myocardial Ischemia; Observer Variation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prevalence; Receptors, Purinergic P2Y12; Reference Standards; Ticlopidine; Treatment Failure | 2012 |
Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and meta-analysis of randomized controlled trials.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Databases, Factual; Dipyridamole; Disease-Free Survival; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Stroke; Survival Rate; Ticlopidine | 2012 |
Inconsistencies surrounding the risk of adverse outcomes with concomitant use of clopidogrel and proton pump inhibitors.
Topics: Animals; Blood Platelets; Clopidogrel; Drug Interactions; Evidence-Based Medicine; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2012 |
Oral antiplatelet therapy in patients with diabetes mellitus and acute coronary syndromes.
Topics: Acute Coronary Syndrome; Administration, Oral; Aspirin; Cilostazol; Clopidogrel; Diabetes Complications; Humans; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Treatment Outcome | 2010 |
Clopidogrel dilemma for orthopaedic surgeons.
Topics: Attitude of Health Personnel; Blood Loss, Surgical; Clopidogrel; Decision Making; Dose-Response Relationship, Drug; Drug-Eluting Stents; Evidence-Based Medicine; Female; Humans; Male; Orthopedic Procedures; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Practice Guidelines as Topic; Risk Assessment; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
An insight into the interaction between clopidogrel and proton pump inhibitors.
Topics: Clopidogrel; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine | 2012 |
Prasugrel versus clopidogrel antiplatelet therapy after acute coronary syndrome: matching treatments with patients.
Topics: Acute Coronary Syndrome; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Secondary Prevention; Thiophenes; Ticlopidine | 2012 |
Cilostazol and primary-PCI: mirage or good alternative?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Arrhythmias, Cardiac; Aspirin; Cilostazol; Clopidogrel; Combined Modality Therapy; Coronary Restenosis; Drug Therapy, Combination; Heart Failure; Humans; Phosphodiesterase 3 Inhibitors; Platelet Aggregation Inhibitors; Prodrugs; Risk; Stents; Tetrazoles; Thrombosis; Ticlopidine | 2012 |
Effects of combined aspirin and clopidogrel therapy on cardiovascular outcomes: a systematic review and meta-analysis.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Randomized Controlled Trials as Topic; Stroke; Ticlopidine; Treatment Outcome | 2012 |
The clinical relevance of the clopidogrel-proton pump inhibitor interaction.
Topics: Animals; Biotransformation; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Evidence-Based Medicine; Gastrointestinal Hemorrhage; Genotype; Humans; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Practice Guidelines as Topic; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2012 |
Advances in antiplatelet therapy for acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Aspirin; Clopidogrel; Emergency Treatment; Female; Humans; Male; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Quinazolinones; Sulfonamides; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Biomarkers, Pharmacological; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Genotype; Humans; Polymorphism, Genetic; Ticlopidine; Warfarin | 2012 |
Optimal drug therapy after aspirin-induced upper gastrointestinal bleeding.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2012 |
Genetic and non-genetic factors affecting the response to clopidogrel therapy.
Topics: Cardiovascular Diseases; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2012 |
High platelet reactivity and antiplatelet therapy resistance.
Topics: Aged; Biological Availability; Blood Platelets; Clopidogrel; Cyclooxygenase 1; Diabetes Complications; Drug Resistance; Humans; Patient Compliance; Platelet Activation; Platelet Aggregation; Ticlopidine | 2012 |
Acute coronary syndromes: identifying the appropriate patient for prasugrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Hemorrhage; Humans; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Assessment; Secondary Prevention; Thiophenes; Ticlopidine | 2012 |
Current trial-associated outcomes with warfarin in prevention of stroke in patients with nonvalvular atrial fibrillation: a meta-analysis.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Azetidines; Benzylamines; Brain Ischemia; Clopidogrel; Female; Humans; Incidence; Male; Oligosaccharides; Primary Prevention; Pyrazoles; Pyridones; Randomized Controlled Trials as Topic; Stroke; Ticlopidine; Treatment Outcome; United States; Warfarin | 2012 |
What do you do with the antiplatelet agents in patients with drug eluting stents who then receive a mechanical valve?
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Animals; Anticoagulants; Aspirin; Benchmarking; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Evidence-Based Medicine; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Hemorrhage; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Assessment; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: meta-analysis.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Observational Studies as Topic; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Registries; Risk Factors; Ticlopidine | 2013 |
Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis.
Topics: Aryldialkylphosphatase; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 2012 |
Perioperative management of antiplatelet agents in patients undergoing cardiac surgery.
Topics: Adenosine; Adenosine Monophosphate; Aspirin; Clopidogrel; Coronary Artery Bypass; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticagrelor; Ticlopidine | 2012 |
Current antiplatelet options for NSTE-ACS patients.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Biological Availability; Clopidogrel; Comparative Effectiveness Research; Drug Monitoring; Drug Synergism; Drug Therapy, Combination; Electrocardiography; Humans; Pharmacovigilance; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y; Risk Assessment; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Systematic review and meta-analysis of the association between cytochrome P450 2C19 genotype and bleeding.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Hemorrhage; Humans; Polymorphism, Genetic; Risk; Thrombosis; Ticlopidine | 2012 |
Platelet function and inhibition in ischemic heart disease.
Topics: Blood Platelets; Clopidogrel; Drug Resistance; Hemorrhage; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Thrombin; Ticlopidine | 2012 |
Adverse cardiovascular effects of concomitant use of proton pump inhibitors and clopidogrel in patients with coronary artery disease: a systematic review and meta-analysis.
Topics: Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Humans; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2012 |
Comparative pharmacokinetics and pharmacodynamics of platelet adenosine diphosphate receptor antagonists and their clinical implications.
Topics: Adenosine; Cardiovascular Diseases; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Use of aspirin and clopidogrel after coronary artery bypass graft surgery.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Switching antiplatelet regimens: alternatives to clopidogrel in patients with acute coronary syndrome undergoing PCI: a review of the literature and practical considerations for the interventional cardiologist.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Interactions; Drug Substitution; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Pharmacogenetics; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
The effectiveness and safety of triple-antiplatelet treatment based on cilostazol for patients receiving percutaneous coronary intervention: a meta-analysis.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Confidence Intervals; Coronary Artery Disease; Coronary Restenosis; Drug Therapy, Combination; Humans; Odds Ratio; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine | 2012 |
Meta-analysis of cytochrome P450 2C19 polymorphism and risk of adverse clinical outcomes among coronary artery disease patients of different ethnic groups treated with clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cohort Studies; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Ethnicity; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Randomized Controlled Trials as Topic; Risk Assessment; Ticlopidine; Treatment Outcome | 2012 |
Clopidogrel and proton pump inhibitors--where do we stand in 2012?
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Aspirin; Biotransformation; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2012 |
[New antithrombotic drugs].
Topics: Adenosine; Anticoagulants; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Hemorrhage; Humans; Morpholines; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyrazoles; Pyridones; Rivaroxaban; Thiophenes; Ticagrelor; Ticlopidine; Warfarin | 2012 |
Prevention of stroke in patients with atrial fibrillation: anticoagulant and antiplatelet options.
Topics: Anticoagulants; Antithrombins; Aspirin; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Hemorrhage; Humans; Morpholines; Practice Guidelines as Topic; Pyrazoles; Pyridines; Pyridones; Risk Assessment; Rivaroxaban; Stroke; Thiazoles; Thiophenes; Thrombolytic Therapy; Ticlopidine; Warfarin | 2012 |
Latest evidence in personalized antiplatelet therapy in patients with acute coronary syndromes undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Resistance; Evidence-Based Medicine; Genotype; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2012 |
Advantages and limitations of clopidogrel response testing methods.
Topics: Clopidogrel; Drug Monitoring; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Agonists; Ticlopidine | 2012 |
Translational platelet research in patients with coronary artery disease: what are the major knowledge gaps?
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Biomarkers, Pharmacological; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Translational Research, Biomedical; Treatment Outcome | 2012 |
Network meta-analysis of prasugrel, ticagrelor, high- and standard-dose clopidogrel in patients scheduled for percutaneous coronary interventions.
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty; Cardiovascular Diseases; Clopidogrel; Hemorrhage; Humans; Odds Ratio; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Risk; Stents; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Personalized medicine: hope or hype?
Topics: Anticoagulants; Cardiovascular Diseases; Clopidogrel; Genetic Predisposition to Disease; Genetic Testing; Genetic Variation; Genome, Human; Humans; Mutation; Neoplasms; Pharmacogenetics; Platelet Aggregation Inhibitors; Precision Medicine; Risk Adjustment; Ticlopidine; Warfarin | 2012 |
Use of cilostazol in percutaneous coronary interventions.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Phosphodiesterase 3 Inhibitors; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Vasodilator Agents | 2012 |
Utility of platelet transfusion in adult patients with traumatic intracranial hemorrhage and preinjury antiplatelet use: a systematic review.
Topics: Adult; Aspirin; Clopidogrel; Cohort Studies; Emergency Service, Hospital; Evidence-Based Medicine; Female; Hospital Mortality; Humans; Injury Severity Score; Intracranial Hemorrhage, Traumatic; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Prognosis; Registries; Retrospective Studies; Risk Assessment; Survival Analysis; Ticlopidine; Trauma Centers; Treatment Outcome | 2012 |
[Platelet function: new drugs, new assays : possible impacts on operative medicine?].
Topics: Adenosine; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Postoperative Complications; Postoperative Hemorrhage; Practice Guidelines as Topic; Prasugrel Hydrochloride; Predictive Value of Tests; Stents; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2012 |
Ticagrelor: a P2Y12 antagonist for use in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Kaplan-Meier Estimate; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Product Surveillance, Postmarketing; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Interindividual variability in the efficacy of oral antiplatelet drugs: definitions, mechanisms and clinical importance.
Topics: Administration, Oral; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Comorbidity; Drug Interactions; Drug Resistance; Genotype; Humans; Medication Adherence; Patient Selection; Phenotype; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticlopidine; Treatment Outcome | 2012 |
Clinical use of clopidogrel.
Topics: Blood Platelets; Calcium Channel Blockers; Cardiovascular Diseases; Clopidogrel; Drug Design; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Patient Selection; Platelet Aggregation Inhibitors; Platelet Function Tests; Practice Guidelines as Topic; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Treatment Outcome | 2012 |
Development and clinical use of prasugrel and ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Animals; Aspirin; Blood Platelets; Clopidogrel; Drug Design; Hemorrhage; Hemostasis; Humans; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Challenges and perspectives of antiplatelet therapy in patients with diabetes mellitus and coronary artery disease.
Topics: Aspirin; Blood Glucose; Blood Platelets; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; Insulin; Insulin Resistance; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Treatment Outcome | 2012 |
Pharmacogenetics of clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Blood Platelets; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Resistance; Genetic Testing; Genotype; Humans; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2012 |
Tailoring antiplatelet therapy: a step toward individualized therapy to improve clinical outcome?
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Blood Platelets; Clopidogrel; Coronary Thrombosis; Drug Interactions; Drug Resistance; Genotype; Hemorrhage; Humans; Patient Selection; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Precision Medicine; Predictive Value of Tests; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Investigating incoherence gives insight: clopidogrel is equivalent to extended-release dipyridamole plus aspirin in secondary stroke prevention.
Topics: Aspirin; Clopidogrel; Confounding Factors, Epidemiologic; Dipyridamole; Drug Therapy, Combination; Humans; Logistic Models; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2012 |
Cilostazol added to aspirin and clopidogrel reduces revascularization without increases in major adverse events in patients with drug-eluting stents: a meta-analysis of randomized controlled trials.
Topics: Aspirin; Cardiovascular Diseases; Cilostazol; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Tetrazoles; Ticlopidine | 2013 |
Anticoagulants for the treatment of acute coronary syndrome in the era of new oral agents.
Topics: Acute Coronary Syndrome; Administration, Oral; Anticoagulants; Antithrombins; Aspirin; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Drug Therapy, Combination; Factor Xa Inhibitors; Hemorrhage; Heparin; Humans; Morpholines; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Rivaroxaban; Thiophenes; Ticlopidine; Warfarin | 2012 |
A brief review of the past and future of platelet P2Y12 antagonist.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Clopidogrel; Coronary Artery Disease; Humans; Myocardial Infarction; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Quinazolinones; Stents; Sulfonamides; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2012 |
Antiplatelet therapy beyond 2012: role of personalized medicine.
Topics: Adenosine; Clopidogrel; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2012 |
Importance of potent P2Y(12) receptor blockade in acute myocardial infarction: focus on prasugrel.
Topics: Clopidogrel; Costs and Cost Analysis; Drug Interactions; Humans; Myocardial Infarction; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2012 |
Advances in platelet function testing assessing bleeding complications in patients with coronary artery disease.
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Risk; Thrombosis; Ticlopidine | 2012 |
Effect of addition of clopidogrel to aspirin on mortality: systematic review of randomized trials.
Topics: Adult; Aged; Aspirin; Cause of Death; Cerebral Hemorrhage; Clopidogrel; Data Interpretation, Statistical; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2012 |
A meta-analysis of randomized controlled trials appraising the efficacy and safety of cilostazol after coronary artery stent implantation.
Topics: Aspirin; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Cilostazol; Clopidogrel; Combined Modality Therapy; Coronary Restenosis; Drug Therapy, Combination; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Stents; Tetrazoles; Ticlopidine; Treatment Outcome | 2012 |
Cilostazol-based triple antiplatelet therapy compared to dual antiplatelet therapy in patients with coronary stent implantation: a meta-analysis of 5,821 patients.
Topics: Acute Coronary Syndrome; Aspirin; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Cilostazol; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome | 2012 |
[Comparative antiplatelet efficacy of prasugrel and high-dose clopidogrel in patients with coronary heart disease including acute coronary syndrome].
Topics: Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome- a systematic review.
Topics: Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Humans; Odds Ratio; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2013 |
Acute ST-elevation myocardial infarction.
Topics: Abciximab; Antibodies, Monoclonal; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Hemodynamics; Humans; Hypothermia, Induced; Immunoglobulin Fab Fragments; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
A meta-analysis to determine the effect of preinjury antiplatelet agents on mortality in patients with blunt head trauma.
Topics: Aged; Anticoagulants; Aspirin; Blood Coagulation Disorders; Clopidogrel; Epidemiologic Methods; Head Injuries, Closed; Humans; Intracranial Hemorrhage, Traumatic; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Impact of antiplatelet therapy in heart disease.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Heart Diseases; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine; Treatment Outcome | 2012 |
Clopidogrel in coronary artery disease: update 2012.
Topics: Adenosine; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Genetic considerations.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Genome-Wide Association Study; Genotype; Humans; Liver; Pharmacogenetics; Phenotype; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2012 |
Stents and antiplatelet therapy.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Factors; Stents; Thienopyridines; Thrombosis; Ticlopidine | 2012 |
Bleeding and the use of antiplatelet agents in the management of acute coronary syndromes and atrial fibrillation.
Topics: Acute Coronary Syndrome; Aspirin; Atrial Fibrillation; Clinical Trials as Topic; Clopidogrel; Hemorrhage; Hospital Mortality; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2Y Receptor Antagonists; Risk Assessment; Ticlopidine | 2012 |
Antiplatelet therapy in stroke prevention.
Topics: Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Primary Prevention; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke; Ticlopidine | 2012 |
Challenges in atrial fibrillation.
Topics: Aspirin; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Drug Therapy, Combination; Humans; International Normalized Ratio; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2012 |
Advances in the monitoring of anti-P2Y12 therapy.
Topics: Adenosine; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Precision Medicine; Prodrugs; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Thienopyridines and other ADP-receptor antagonists.
Topics: Adenosine; Adenosine Monophosphate; Animals; Clopidogrel; Humans; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Quinazolinones; Sulfonamides; Thienopyridines; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Variability of platelet indices and function: acquired and genetic factors.
Topics: Aspirin; Blood Platelets; Cell Size; Clopidogrel; Genome-Wide Association Study; Humans; Platelet Count; Polymorphism, Single Nucleotide; Ticlopidine | 2012 |
Pharmacological modulation of the inflammatory actions of platelets.
Topics: Animals; Blood Platelets; Clopidogrel; Humans; Inflammation; NF-kappa B; Platelet Activation; Platelet Adhesiveness; Ticlopidine | 2012 |
The role of laboratory monitoring in antiplatelet therapy.
Topics: Aspirin; Blood Platelets; Clopidogrel; Cost-Benefit Analysis; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2012 |
Antiplatelet therapy in cerebrovascular disorders.
Topics: Anticoagulants; Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2012 |
Primary prevention of ischaemic cardiovascular disorders with antiplatelet agents.
Topics: Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Humans; Ischemia; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Thrombosis; Ticlopidine | 2012 |
Review of ticagrelor in the management of acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Dyspnea; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2012 |
Antiplatelet treatment in primary and secondary stroke prevention in women.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Humans; Naphthalenes; Platelet Aggregation Inhibitors; Primary Prevention; Propionates; Salicylates; Secondary Prevention; Sex Factors; Stroke; Ticlopidine | 2012 |
Personalizing antiplatelet therapy with clopidogrel.
Topics: Blood Platelets; Clopidogrel; Genotype; Humans; Phenotype; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine; Treatment Outcome | 2012 |
Safety profile and bleeding risk of ticagrelor compared with clopidogrel.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Dyspnea; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticagrelor; Ticlopidine | 2012 |
Clinical importance of antiplatelet drugs in cardiovascular diseases.
Topics: Acute Coronary Syndrome; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase Inhibitors; Humans; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2013 |
Reducing adverse effects of proton pump inhibitors.
Topics: Anemia, Iron-Deficiency; Clopidogrel; Clostridioides difficile; Critical Care; Diarrhea; Drug Interactions; Enterocolitis, Pseudomembranous; Gastroesophageal Reflux; Gastrointestinal Hemorrhage; Hip Fractures; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pneumonia; Proton Pump Inhibitors; Recurrence; Risk Factors; Stomach Ulcer; Stress, Physiological; Ticlopidine; Ulcer | 2012 |
Stroke genetics: prospects for personalized medicine.
Topics: Anticoagulants; Clopidogrel; Genetic Variation; Humans; Pharmacogenetics; Precision Medicine; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Warfarin | 2012 |
Mechanisms of variability in antiplatelet agents response.
Topics: Aspirin; Biotransformation; Clopidogrel; Drug Monitoring; Drug Resistance; Genotype; Humans; Patient Selection; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Predictive Value of Tests; Ticlopidine | 2012 |
New anti-platelet agents: the end of resistance?
Topics: Adenosine; Animals; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Design; Drug Resistance; Drug Therapy, Combination; Evidence-Based Medicine; Hemorrhage; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Antithrombotic therapy.
Topics: Animals; Anticoagulants; Aspirin; Blood Coagulation Disorders; Cat Diseases; Cats; Clopidogrel; Dog Diseases; Dogs; Heparin; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine; Warfarin | 2012 |
Diagnosis and management of high platelet reactivity on treatment with clopidogrel.
Topics: Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2012 |
ABCB1 C3435T polymorphism and response to clopidogrel treatment in coronary artery disease (CAD) patients: a meta-analysis.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2012 |
Clopidogrel: the data, the experience, and the controversies.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2012 |
Why does ticagrelor induce dyspnea?
Topics: Adenosine; Clopidogrel; Dyspnea; Humans; Models, Biological; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Sensory Receptor Cells; Ticagrelor; Ticlopidine | 2012 |
Underreporting of hemorrhagic and thrombotic complications of pharmaceuticals to the U.S. Food and Drug Administration: empirical findings for warfarin, clopidogrel, ticlopidine, and thalidomide from the Southern Network on Adverse Reactions (SONAR).
Topics: Adverse Drug Reaction Reporting Systems; Clopidogrel; Hemorrhage; Humans; Thalidomide; Thrombosis; Ticlopidine; United States; United States Food and Drug Administration; Warfarin | 2012 |
The clopidogrel-PPI interaction: an updated mini-review.
Topics: Animals; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2014 |
A critical overview on ticagrelor in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Double-Blind Method; Female; Humans; Male; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Assessment; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
[Pharmacogenetics of clopidogrel and its clinical significance].
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Resistance; Humans; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2012 |
Genetic polymorphisms and drug interactions leading to clopidogrel resistance: why the Asian population requires special attention.
Topics: Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2013 |
Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR).
Topics: Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purpura, Thrombotic Thrombocytopenic; Thienopyridines; Thiophenes; Ticlopidine | 2012 |
Clopidogrel treatment and the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Cohort Studies; Community-Acquired Infections; Critical Illness; Databases, Factual; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Pneumonia; Severity of Illness Index; Ticlopidine; Treatment Outcome; Young Adult | 2013 |
[Antithrombotic therapy after peripheral vascular treatment: what is evidence-based?].
Topics: Aortic Diseases; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endarterectomy; Evidence-Based Medicine; Femoral Artery; Fibrinolytic Agents; Follow-Up Studies; Humans; Iliac Artery; International Normalized Ratio; Peripheral Arterial Disease; Polyethylene Terephthalates; Polytetrafluoroethylene; Popliteal Artery; Postoperative Complications; Prosthesis Design; Ticlopidine; Veins; Vitamin K | 2012 |
Dual antiplatelet therapy for primary and secondary prevention.
Topics: Acute Coronary Syndrome; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Primary Prevention; Secondary Prevention; Ticlopidine | 2012 |
Clinical impact of genetically determined platelet reactivity.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blood Platelets; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Resistance; Genotype; Humans; Patient Selection; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Stents; Ticlopidine; Treatment Outcome | 2013 |
Adenosine-diphosphate (ADP) receptor antagonists for the prevention of cardiovascular disease in type 2 diabetes mellitus.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Diabetes Mellitus, Type 2; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticlopidine | 2012 |
The discovery of a new class of synaptic transmitters in smooth muscle 50 years ago and amelioration of coronary artery thrombosis.
Topics: Adenosine; Animals; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; History, 20th Century; Humans; Muscle, Smooth; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y; Ticagrelor; Ticlopidine | 2013 |
[Genetic factors influencing efficacy of clopidogrel treatment].
Topics: Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Blood Platelets; Clopidogrel; Drug Resistance; Humans; Liver; Myocardial Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2012 |
Branded versus generic clopidogrel in cardiovascular diseases: a systematic review.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drugs, Generic; Humans; Patents as Topic; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; United States | 2013 |
[Proton pump inhibitors and clopidogrel: an association to avoid?].
Topics: Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2012 |
Impact of clopidogrel and potent P2Y 12 -inhibitors on mortality and stroke in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Thrombosis; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Stroke; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Comparing newer oral anti-platelets prasugrel and ticagrelor in reduction of ischemic events-evidence from a network meta-analysis.
Topics: Adenosine; Clopidogrel; Hemorrhage; Humans; Ischemia; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; PubMed; Randomized Controlled Trials as Topic; Stents; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2013 |
Clopidogrel, aspirin and proton pump inhibition after percutaneous valve implants: an update.
Topics: Aspirin; Clopidogrel; Heart Valve Prosthesis Implantation; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Review Literature as Topic; Ticlopidine | 2013 |
High on-treatment platelet reactivity and P2Y12 antagonists in clinical trials.
Topics: Blood Platelets; Clinical Trials as Topic; Clopidogrel; Drug Interactions; Evidence-Based Medicine; Humans; Pharmacogenetics; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Assessment; Ticlopidine; Treatment Outcome | 2013 |
[Novel agents for antithrombotic therapy in cardiology].
Topics: Adenosine; Administration, Oral; Anticoagulants; Aspirin; Clopidogrel; Coumarins; Fibrinolytic Agents; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Thrombolytic Therapy; Ticagrelor; Ticlopidine | 2012 |
Platelet function monitoring and clopidogrel.
Topics: Blood Platelets; Clopidogrel; Drug Monitoring; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2013 |
Antiplatelet drug resistance and variability in response: the role of antiplatelet therapy monitoring.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Cost Savings; Drug Monitoring; Drug Resistance; Drug Substitution; Drug Therapy, Combination; Humans; Ischemia; Platelet Aggregation Inhibitors; Secondary Prevention; Thrombosis; Ticlopidine | 2013 |
Acute ischemic cerebrovascular events on antiplatelet therapy: what is the optimal prevention strategy?
Topics: Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Dose-Response Relationship, Drug; Humans; Life Style; Medication Adherence; Patient Education as Topic; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Stroke; Ticlopidine | 2013 |
Association of clopidogrel pretreatment with mortality, cardiovascular events, and major bleeding among patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Disease; Endpoint Determination; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Preoperative Care; Randomized Controlled Trials as Topic; Registries; Stroke; Ticlopidine; Treatment Outcome | 2012 |
Aspirin and clopidogrel resistance: possible mechanisms and clinical relevance. Part I: Concept of resistance.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2012 |
Metabolic differences of current thienopyridine antiplatelet agents.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Fibrinolytic Agents; Hemorrhage; Humans; Inactivation, Metabolic; Pharmacogenetics; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Pyridines; Thiophenes; Ticlopidine | 2013 |
Drug interactions in the treatment of depression in patients with ischemic heart disease.
Topics: Aged; Antidepressive Agents; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Comorbidity; Cytochrome P-450 CYP2C19; Depressive Disorder, Major; Drug Interactions; Drug Therapy, Combination; Early Diagnosis; Fluoxetine; Fluvoxamine; Gastrointestinal Hemorrhage; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Factors; Selective Serotonin Reuptake Inhibitors; Ticlopidine | 2012 |
Aspirin and clopidogrel for prevention of ischemic stroke.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2013 |
Cytochrome P450 2C19 polymorphism and antiplatelet therapy. Who should really be genotyped?
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2013 |
Quantitative determination of clopidogrel and its metabolites in biological samples: a mini-review.
Topics: Chromatography, Liquid; Clopidogrel; Humans; Sensitivity and Specificity; Tandem Mass Spectrometry; Ticlopidine | 2013 |
Dual antiplatelet therapy with prasugrel or ticagrelor versus clopidogrel in interventional cardiology.
Topics: Adenosine; Cardiovascular Diseases; Clopidogrel; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Stents; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Antiplatelet drug use in patients with non-ST-segment elevation acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Controversies in the use & implementation of drug-eluting stent technology.
Topics: Absorbable Implants; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coated Materials, Biocompatible; Coronary Restenosis; Cytochrome P-450 CYP2C19; Drug Resistance; Drug-Eluting Stents; History, 20th Century; History, 21st Century; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2012 |
Considerations in antithrombotic therapy among patients undergoing transcatheter aortic valve implantation.
Topics: Aortic Valve Stenosis; Aspirin; Cardiac Catheterization; Clopidogrel; Fibrinolytic Agents; Heart Valve Prosthesis; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Guidelines as Topic; Ticlopidine; Time Factors | 2013 |
Expert position paper on the use of proton pump inhibitors in patients with cardiovascular disease and antithrombotic therapy.
Topics: Adenosine; Aspirin; Benzimidazoles; beta-Alanine; Cardiovascular Diseases; Clopidogrel; Dabigatran; Drug Interactions; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; Warfarin | 2013 |
Clinical consequences of aspirin and clopidogrel resistance: an overview.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Addition of cilostazol to conventional dual antiplatelet therapy reduces the risk of cardiac events and restenosis after drug-eluting stent implantation: a meta-analysis.
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Heart Diseases; Humans; Male; Middle Aged; Myocardial Revascularization; Odds Ratio; Platelet Aggregation Inhibitors; Risk; Tetrazoles; Ticlopidine | 2013 |
Pharmacodynamic impacts of proton pump inhibitors on the efficacy of clopidogrel in vivo--a systematic review.
Topics: Adenosine Diphosphate; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Resistance; Gastrointestinal Diseases; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Receptors, Purinergic P2Y12; Ticlopidine | 2013 |
Prehospital treatment of ST-segment elevated myocardial infarction patients.
Topics: Antithrombins; Clopidogrel; Electrocardiography; Emergency Medical Services; Hirudins; Humans; Myocardial Infarction; Myocardial Reperfusion; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recombinant Proteins; Registries; Survival Analysis; Thrombolytic Therapy; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Dual antiplatelet therapy with aspirin and clopidogrel: what is the risk in noncardiac surgery? A narrative review.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; PubMed; Risk Assessment; Stents; Surgical Procedures, Operative; Thrombosis; Ticlopidine | 2013 |
Dual antiplatelet therapy in patients with diabetes mellitus: special considerations.
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Diabetes Mellitus; Diabetic Angiopathies; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Clopidogrel and warfarin pharmacogenetic tests: what is the evidence for use in clinical practice?
Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Genetic Testing; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine; Warfarin | 2013 |
[Genetic variability in the efficacy of clopidogrel].
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Stents; Ticlopidine; Treatment Outcome | 2013 |
Dual anti-platelet therapy after coronary artery bypass grafting: is there any benefit? A systematic review and meta-analysis.
Topics: Angina Pectoris; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Graft Occlusion, Vascular; Humans; Models, Statistical; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Postoperative Hemorrhage; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2013 |
Diagnosis and management of carotid atherosclerosis.
Topics: Carotid Artery Diseases; Carotid Artery, Common; Clopidogrel; Endarterectomy, Carotid; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Angiography; Male; Patient Safety; Patient Selection; Platelet Aggregation Inhibitors; Postoperative Complications; Prognosis; Risk Assessment; Severity of Illness Index; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome; Ultrasonography, Doppler, Duplex; United Kingdom | 2013 |
Impact of proton pump inhibitor therapy on the efficacy of clopidogrel in the CAPRIE and CREDO trials.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Brain Ischemia; Chi-Square Distribution; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2013 |
Meta-analysis: colonoscopic post-polypectomy bleeding in patients on continued clopidogrel therapy.
Topics: Clopidogrel; Colonic Polyps; Colonoscopy; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Factors; Ticlopidine; Time Factors | 2013 |
Endoscopic procedures in patients under clopidogrel/dual antiplatelet therapy: to do or not to do?
Topics: Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Gastrointestinal Hemorrhage; Humans; Intestinal Polyps; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2013 |
The role of clopidogrel in the management of ischemic heart disease.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Practice Guidelines as Topic; Preoperative Care; Randomized Controlled Trials as Topic; Ticlopidine | 2013 |
Adenosine diphosphate receptor blockade in coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Animals; Clinical Trials as Topic; Clopidogrel; Drug Synergism; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2004 |
A transition of P2Y12 antagonists for acute coronary syndrome: benefits, risks and costs.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Hemorrhage; Humans; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
Monitoring aspirin and clopidogrel response: testing controversies and recommendations.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Stents; Thrombosis; Ticlopidine | 2013 |
Cigarette smoking and clopidogrel interaction.
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Smoking; Smoking Cessation; Ticlopidine | 2013 |
Perioperative management of anticoagulation in elective surgery.
Topics: Anticoagulants; Antithrombins; Benzimidazoles; beta-Alanine; Blood Loss, Surgical; Cardiovascular Diseases; Clopidogrel; Dabigatran; Elective Surgical Procedures; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Assessment; Thromboembolism; Ticlopidine; Withholding Treatment | 2013 |
Aspirin and clopidogrel resistance: possible mechanisms and clinical relevance. Part II: Potential causes and laboratory tests.
Topics: Age Factors; Aspirin; Biological Availability; Clopidogrel; Drug Administration Schedule; Drug Interactions; Drug Resistance; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Sex Factors; Signal Transduction; Thromboxanes; Ticlopidine | 2013 |
Suboptimal response to clopidogrel: a genetic risk factor for recurrent ischaemic stroke.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Genotype; Humans; Ischemia; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Secondary Prevention; Stroke; Ticlopidine | 2013 |
Antiplatelet therapy and cardiac surgery: review of recent evidence and clinical implications.
Topics: Adenosine; Blood Loss, Surgical; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
ADP-receptor inhibitors in the perioperative period: the good, the bad, and the ugly.
Topics: Adenosine; Cardiac Surgical Procedures; Clopidogrel; Hemorrhage; Humans; Perioperative Care; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Surgical Procedures, Operative; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Efficacy and safety of triple-antiplatelet therapy after percutaneous coronary intervention: a meta-analysis.
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Publication Bias; Stents; Tetrazoles; Ticlopidine | 2013 |
[Prominent features of management strategies in acute coronary syndromes with the new oral antiplatelet agents].
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Challenges and limitations in the interpretation of systematic reviews: making sense of clopidogrel and CYP2C19 pharmacogenetics.
Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Endpoint Determination; Genotype; Humans; Meta-Analysis as Topic; Models, Statistical; Patient Selection; Platelet Aggregation Inhibitors; Publication Bias; Research Design; Review Literature as Topic; Ticlopidine | 2013 |
Pharmacogenetics and cardiovascular disease--implications for personalized medicine.
Topics: Animals; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cardiovascular Agents; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver-Specific Organic Anion Transporter 1; Mixed Function Oxygenases; Organic Anion Transporters; Patient Selection; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Precision Medicine; Risk Assessment; Risk Factors; Ticlopidine; Vitamin K Epoxide Reductases; Warfarin | 2013 |
Pharmacogenomics and cardiovascular disease.
Topics: Adrenergic beta-Antagonists; Cardiovascular Agents; Cardiovascular Diseases; Clopidogrel; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Polymorphism, Genetic; Practice Guidelines as Topic; Ticlopidine; Warfarin | 2013 |
Effect of addition of clopidogrel to aspirin on stroke incidence: Meta-analysis of randomized trials.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2015 |
Proton pump inhibitors and potential interactions with clopidogrel: an update.
Topics: Cardiovascular Diseases; Clopidogrel; Confounding Factors, Epidemiologic; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2013 |
Pharmacogenomics of anti-platelet therapy: how much evidence is enough for clinical implementation?
Topics: Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Evidence-Based Medicine; Genotype; Humans; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2013 |
Triple therapy (aspirin, clopidogrel and oral anticoagulant) after percutaneous coronary intervention: another call for personalized medicine.
Topics: Administration, Oral; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Postoperative Complications; Ticlopidine | 2013 |
New anticoagulant and antiplatelet agents: a primer for the gastroenterologist.
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Blood Coagulation Factors; Cholangiopancreatography, Endoscopic Retrograde; Clopidogrel; Dabigatran; Drug Interactions; Fondaparinux; Gastrointestinal Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Polysaccharides; Prasugrel Hydrochloride; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2014 |
The impact of smoking on clinical efficacy and pharmacodynamic effects of clopidogrel: a systematic review and meta-analysis.
Topics: Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Smoking; Ticlopidine; Treatment Outcome | 2014 |
Pharmacokinetic considerations for antithrombotic therapies in stroke.
Topics: Administration, Oral; Anticoagulants; Aspirin; Atrial Fibrillation; Cilostazol; Clopidogrel; Factor Xa; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Stroke; Tetrazoles; Thiophenes; Thrombin; Ticlopidine; Vitamin K | 2013 |
Aspirin, clopidogrel, and ticagrelor in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Secondary Prevention; Ticagrelor; Ticlopidine; Treatment Outcome; United States | 2013 |
Closing the loop: a 21-year audit of strategies for preventing stroke and death following carotid endarterectomy.
Topics: Angioscopy; Aspirin; Carotid Artery Diseases; Clinical Protocols; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Humans; Hypertension; Intracranial Embolism; Intracranial Hemorrhages; Intraoperative Care; Medical Audit; Platelet Aggregation Inhibitors; Postoperative Care; Practice Guidelines as Topic; Predictive Value of Tests; Quality of Health Care; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2013 |
[Secondary prevention with clopidogrel after TIA or stroke].
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Netherlands; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2013 |
Pharmacogenomics of anti-platelet and anti-coagulation therapy.
Topics: Anticoagulants; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2013 |
Late and very late stent thrombosis in patients with second-generation drug-eluting stents.
Topics: Aspirin; Cardiotonic Agents; Clopidogrel; Drug-Eluting Stents; Everolimus; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Sirolimus; Thrombosis; Ticlopidine; Time Factors | 2013 |
The efficacy and adverse reaction of bleeding of clopidogrel plus aspirin as compared to aspirin alone after stroke or TIA: a systematic review.
Topics: Aspirin; Bleeding Time; Clopidogrel; Hemorrhage; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine; Treatment Outcome | 2013 |
Use of antiplatelet drugs in the treatment of acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2013 |
Comparison of on-treatment platelet reactivity between triple antiplatelet therapy with cilostazol and standard dual antiplatelet therapy in patients undergoing coronary interventions: a meta-analysis.
Topics: Aspirin; Blood Platelets; Cilostazol; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Tetrazoles; Thromboembolism; Ticlopidine | 2013 |
Clopidogrel generic formulations in the era of new antiplatelets: a systematic review.
Topics: Animals; Cardiovascular Diseases; Chemistry, Pharmaceutical; Clinical Trials as Topic; Clopidogrel; Drugs, Generic; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
High on-treatment platelet reactivity in peripheral endovascular procedures.
Topics: Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Endovascular Procedures; Humans; Peripheral Arterial Disease; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
[Statin and clopidogrel pharmacological interaction].
Topics: Clinical Trials as Topic; Clopidogrel; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Perioperative management of antiplatelet therapy in patients with a coronary stent who need noncardiac surgery: a systematic review of clinical practice guidelines.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Elective Surgical Procedures; Hemorrhage; Humans; Metals; Perioperative Care; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stents; Thromboembolism; Ticlopidine; Time Factors; Withholding Treatment | 2013 |
Clopidogrel, prasugrel, or ticagrelor? a practical guide to use of antiplatelet agents in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Decision Support Techniques; Drug Therapy, Combination; Humans; Induction Chemotherapy; Maintenance Chemotherapy; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
[The most important aspects of risk assessment].
Topics: Algorithms; Aspirin; Cardiovascular Diseases; Clopidogrel; Digestive System Surgical Procedures; Drug Substitution; Drug Therapy, Combination; Health Status Indicators; Hemorrhage; Heparin; Humans; Perioperative Period; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Thromboembolism; Ticlopidine; Viscera | 2013 |
New antiplatelet agents and the role of platelet function testing in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Focused 2012 update of the Canadian Cardiovascular Society guidelines for the use of antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine; Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Contraindications; Coronary Artery Bypass; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Secondary Prevention; Stents; Stroke; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2013 |
Genetics of platelet inhibitor treatment.
Topics: Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; Carboxylic Ester Hydrolases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotyping Techniques; Humans; Molecular Sequence Data; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2014 |
Platelet reactivity tests for assessing antiplatelet drug response: what the clinician needs to know.
Topics: Adenosine; Cardiovascular Diseases; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Precision Medicine; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
[Oral antiplatelet agents can still be used along with proton pump inhibitors in spite of drug interactions].
Topics: Adenosine; Administration, Oral; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Piperazines; Prasugrel Hydrochloride; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Thienopyridines; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
New antiplatelet agents for cardiovascular disease.
Topics: Adenosine; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Proton pump inhibitors and clopidogrel: an association to avoid?
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Lansoprazole; Monitoring, Physiologic; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2014 |
Aggressive medical therapy alone is not adequate in certain patients with severe symptomatic carotid stenosis.
Topics: Aspirin; Atorvastatin; Carotid Artery Diseases; Clopidogrel; Constriction, Pathologic; Endovascular Procedures; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2013 |
Cytochrome CYP2C19 polymorphism and risk of adverse clinical events in clopidogrel-treated patients: a meta-analysis based on 23,035 subjects.
Topics: Aryl Hydrocarbon Hydroxylases; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Resistance; Genotype; Humans; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2013 |
Cangrelor versus clopidogrel in percutaneous coronary intervention: a systematic review and meta-analysis.
Topics: Adenosine Monophosphate; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2014 |
Risk-benefit profile of long-term dual- versus single-antiplatelet therapy among patients with ischemic stroke: a systematic review and meta-analysis.
Topics: Anticoagulants; Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Intracranial Hemorrhages; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Risk Assessment; Secondary Prevention; Stroke; Ticlopidine | 2013 |
Long-term clinical efficacy and safety of adding cilostazol to dual antiplatelet therapy for patients undergoing PCI: a meta-analysis of randomized trials with adjusted indirect comparisons.
Topics: Aspirin; Cilostazol; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Treatment Outcome | 2014 |
Pharmacogenetics of antiplatelets and anticoagulants: a report on clopidogrel, warfarin and dabigatran.
Topics: Anticoagulants; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Warfarin | 2013 |
[Thrombocyte aggregation inhibitors: what are the risks?].
Topics: Adenosine; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Risk Factors; Stents; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Anticoagulant and antiplatelet medications encountered in emergency surgery patients: a review of reversal strategies.
Topics: Anticoagulants; Aspirin; Benzimidazoles; Clopidogrel; Dabigatran; Emergencies; Enoxaparin; Fondaparinux; Heparin; Humans; Morpholines; Platelet Aggregation Inhibitors; Platelet Transfusion; Polysaccharides; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Surgical Procedures, Operative; Thiophenes; Ticlopidine; Warfarin | 2013 |
The challenge of stroke prevention with intracranial arterial stenosis.
Topics: Aspirin; Carotid Artery, Common; Carotid Stenosis; Clopidogrel; Constriction, Pathologic; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Intracranial Arteriosclerosis; Male; Platelet Aggregation Inhibitors; Risk Factors; Risk Reduction Behavior; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome; United States; Warfarin | 2013 |
Triple versus dual antiplatelet therapy in acute coronary syndromes: adding cilostazol to aspirin and clopidogrel?
Topics: Acute Coronary Syndrome; Aspirin; Cilostazol; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Phosphodiesterase 3 Inhibitors; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine | 2013 |
Applied pharmacogenomics in cardiovascular medicine.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Antithrombins; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Pharmacogenetics; Polymorphism, Single Nucleotide; Precision Medicine; Ticlopidine; Vitamin K Epoxide Reductases; Warfarin | 2014 |
Use of antiplatelet agents in patients with atherosclerotic disease.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Atherosclerosis; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Dual antiplatelet therapy -- management in general practice.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Combination of a new oral anticoagulant, aspirin and clopidogrel after acute coronary syndrome: new therapeutic standard?
Topics: Acute Coronary Syndrome; Administration, Oral; Anticoagulants; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drug Combinations; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine | 2013 |
Evaluation of antiplatelet agents for secondary prevention of stroke using mixed treatment comparison meta-analysis.
Topics: Aged; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Precision Medicine; Randomized Controlled Trials as Topic; Risk Factors; Secondary Prevention; Stroke; Ticlopidine | 2013 |
Ticagrelor for acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Animals; Clinical Trials, Phase III as Topic; Clopidogrel; Humans; Myocardial Infarction; Purinergic P2Y Receptor Antagonists; Stroke; Ticagrelor; Ticlopidine | 2013 |
[Drug interaction of proton pump inhibitors and clopidogrel taken together].
Topics: Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2013 |
Dyspnea and reversibility of antiplatelet agents: ticagrelor, elinogrel, cangrelor, and beyond.
Topics: Acute Lung Injury; Adenosine; Adenosine Monophosphate; Administration, Oral; Clopidogrel; Dyspnea; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Quinazolinones; Randomized Controlled Trials as Topic; Sulfonamides; Ticagrelor; Ticlopidine; Transfusion Reaction | 2014 |
High-maintenance-dose clopidogrel in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Topics: Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Endpoint Determination; Humans; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2013 |
What's new about clopidogrel.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stents; Thrombosis; Ticlopidine; Treatment Failure | 2013 |
Antiplatelet therapy to prevent recurrent stroke: Three good options.
Topics: Aspirin; Carotid Stenosis; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Stents; Stroke; Ticlopidine | 2013 |
Cardiovascular pharmacogenomics: expectations and practical benefits.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Anticoagulants; Cardiovascular Diseases; Clopidogrel; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pharmacogenetics; Platelet Aggregation Inhibitors; Renin-Angiotensin System; Ticlopidine; Warfarin | 2014 |
Benefits from new ADP antagonists as compared with clopidogrel in patients with stable angina or acute coronary syndrome undergoing invasive management: a meta-analysis of randomized trials.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Angina, Stable; Case Management; Clopidogrel; Endpoint Determination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2014 |
[Antiplatelet therapy: resistance to traditional antiaggregation drugs and role of new antiplatelet agents].
Topics: Acute Coronary Syndrome; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2014 |
Antiplatelet treatment for prevention of cerebrovascular events in patients with vascular diseases: a systematic review and meta-analysis.
Topics: Adenosine; Aged; Aspirin; Cerebral Hemorrhage; Cerebrovascular Disorders; Clopidogrel; Cohort Studies; Data Interpretation, Statistical; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Population; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Secondary Prevention; Stroke; Thiophenes; Ticagrelor; Ticlopidine; Vascular Diseases | 2014 |
Genetic and nongenetic factors influencing the response to clopidogrel.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Resistance; Genotype; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Risk Assessment; Ticlopidine; Treatment Outcome | 2013 |
Potential clinical utility of genetic and platelet function tests in patients on treatment with clopidogrel.
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Drug Administration Schedule; Drug Monitoring; Genetic Testing; Genotype; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2013 |
Characteristics of new P2Y12 inhibitors: selection of P2Y12 inhibitors in clinical practice.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2013 |
Identifying responsiveness to oral P2Y12 receptor blockers: platelet function assays and genetic tests.
Topics: Acute Coronary Syndrome; Administration, Oral; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Drug Monitoring; Genetic Predisposition to Disease; Genetic Testing; Humans; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2013 |
Methodological issues of retrospective studies assessing health outcomes of potential clopidogrel-statin interaction.
Topics: Clopidogrel; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Research Design; Retrospective Studies; Ticlopidine | 2014 |
[Differentiated antiplatelet therapy for acute coronary syndromes].
Topics: Acute Coronary Syndrome; Adenosine; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Platelet Transfusion; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
p2y12 receptor inhibitors in acute coronary syndromes: from the research laboratory to the clinic and vice versa.
Topics: Acute Coronary Syndrome; Aspirin; Clinical Trials as Topic; Clopidogrel; Diabetic Angiopathies; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Renal Insufficiency, Chronic; Ticlopidine; Treatment Outcome | 2014 |
Anticoagulation and antiplatelet therapy in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Anticoagulants; Aspirin; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Enoxaparin; Fondaparinux; Heparin; Hirudins; Humans; Morpholines; Peptide Fragments; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polysaccharides; Prasugrel Hydrochloride; Pyrazoles; Pyridones; Recombinant Proteins; Rivaroxaban; Thiophenes; Ticagrelor; Ticlopidine; Warfarin | 2014 |
Lack of association between dual antiplatelet therapy use and stent thrombosis between 1 and 12 months following resolute zotarolimus-eluting stent implantation.
Topics: Aspirin; Blood Vessel Prosthesis; Clinical Trials as Topic; Clopidogrel; Coronary Thrombosis; Death, Sudden, Cardiac; Drug-Eluting Stents; Female; Fibrinolytic Agents; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Prosthesis Failure; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome; Withholding Treatment | 2014 |
The clopidogrel-statin interaction.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Unanswered questions in patients with concurrent atrial fibrillation and acute coronary syndrome.
Topics: Acute Coronary Syndrome; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Comorbidity; Drug Therapy, Combination; Factor Xa Inhibitors; Humans; Morpholines; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Pyrazoles; Pyridones; Risk Assessment; Rivaroxaban; Stroke; Thiophenes; Thrombosis; Ticlopidine | 2014 |
Impact of new oral or intravenous P2Y12 inhibitors and clopidogrel on major ischemic and bleeding events in patients with coronary artery disease: a meta-analysis of randomized trials.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Administration, Oral; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Fibrinolytic Agents; Hemorrhage; Humans; Injections, Intravenous; Multicenter Studies as Topic; Myocardial Infarction; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Quinazolinones; Randomized Controlled Trials as Topic; Stents; Stroke; Sulfonamides; Thiophenes; Thrombolytic Therapy; Ticagrelor; Ticlopidine | 2014 |
Unravelling the smokers' paradox: cigarette smoking, high-risk coronary artery disease and enhanced clinical efficacy of oral P2Y₁₂ inhibitors.
Topics: Adenosine; Administration, Oral; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Reduction Behavior; Smoking; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Pharmacokinetic evaluation of prasugrel for the treatment of myocardial infarction.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2014 |
[Cardiology. Platelet function testing for clinicians].
Topics: Cardiology; Clopidogrel; Genetic Testing; Humans; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Professional Practice; Ticlopidine; Treatment Outcome | 2014 |
Combining antiplatelet and antithrombotic therapy (triple therapy): what are the risks and benefits?
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Warfarin | 2014 |
Platelet-reactivity tests identify patients at risk of secondary cardiovascular events: a systematic review and meta-analysis.
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Ticlopidine | 2014 |
Pharmacogenomics of oral antiplatelet drugs.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Humans; Meta-Analysis as Topic; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
New antiplatelet agents in the treatment of acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Clinical Trials as Topic; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Coronary Thrombosis; Diabetes Complications; Hemorrhage; Humans; Multicenter Studies as Topic; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Precision Medicine; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Renal Insufficiency; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Rationale and design of The Intracoronary Stenting and Antithrombotic Regimen-Testing of a six-week versus a six-month clopidogrel treatment Regimen In Patients with concomitant aspirin and oraL anticoagulant therapy following drug-Eluting stenting (ISAR-
Topics: Administration, Oral; Aspirin; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Follow-Up Studies; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombolytic Therapy; Ticlopidine | 2014 |
Efficacy and safety of prasugrel in acute coronary syndrome patients.
Topics: Acute Coronary Syndrome; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2014 |
Dyspnea and reversibility profile of P2Y₁₂ antagonists: systematic review of new antiplatelet drugs.
Topics: Adenosine; Adenosine Monophosphate; Clopidogrel; Dyspnea; Humans; Incidence; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Quinazolinones; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Sulfonamides; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
[Use of antiplatelet agents in patients with chronic kidney disease: what is the evidence?].
Topics: Adenosine; Blood Platelet Disorders; Clopidogrel; Evidence-Based Practice; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Renal Insufficiency, Chronic; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2014 |
Overview of pleiotropic effects of platelet P2Y12 receptor inhibitors.
Topics: Adenosine; Adenosine Monophosphate; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Clopidogrel; Drug Therapy, Combination; Humans; Off-Label Use; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Signal Transduction; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Effects of P2Y12 receptor inhibition in patients with ST-segment elevation myocardial infarction.
Topics: Administration, Oral; Aged; Clopidogrel; Combined Modality Therapy; Dose-Response Relationship, Drug; Electrocardiography; Female; Hemorrhage; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Ticlopidine; Treatment Outcome | 2014 |
Successful gestation and delivery using clopidogrel for secondary stroke prophylaxis: a case report and literature review.
Topics: Adult; Clopidogrel; Delivery, Obstetric; Female; Humans; Infant, Newborn; Ischemic Attack, Transient; Male; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Cardiovascular; Secondary Prevention; Stroke; Ticlopidine | 2014 |
[Concept, pathophysiology and treatment for branch atheromatous disease].
Topics: Antipyrine; Arginine; Cerebral Infarction; Cilostazol; Clopidogrel; Contraindications; Drug Therapy, Combination; Edaravone; Humans; Magnetic Resonance Imaging; Pipecolic Acids; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Sulfonamides; Tetrazoles; Ticlopidine; Tissue Plasminogen Activator | 2014 |
Stroke: transient ischemic attack.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain; Clopidogrel; Diffusion Magnetic Resonance Imaging; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Risk Reduction Behavior; Stroke; Ticlopidine; Tomography, X-Ray Computed | 2014 |
Risk of stroke in patients with high on-clopidogrel platelet reactivity to adenosine diphosphate after percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Global Health; Humans; Incidence; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Period; Risk Factors; Stroke; Ticlopidine | 2014 |
Should P2Y12 inhibitors be given for 12 months in acute coronary syndrome?
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Humans; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Stents; Ticlopidine; Time Factors | 2014 |
Update: Acute coronary syndromes (V). Personalized antiplatelet therapy.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Precision Medicine; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Failure | 2014 |
Antiplatelet therapy in critical limb ischemia: update on clopidogrel and cilostazol.
Topics: Cilostazol; Clopidogrel; Combined Modality Therapy; Critical Illness; Drug Therapy, Combination; Endovascular Procedures; Humans; Ischemia; Lower Extremity; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Risk Factors; Stents; Tetrazoles; Ticlopidine; Treatment Outcome | 2014 |
Efficacy and safety of cilostazol based triple antiplatelet treatment versus dual antiplatelet treatment in patients undergoing coronary stent implantation: an updated meta-analysis of the randomized controlled trials.
Topics: Aspirin; Brain Ischemia; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Stroke; Tetrazoles; Thrombosis; Ticlopidine | 2015 |
Front-loading with clopidogrel plus aspirin followed by dual antiplatelet therapy in the prevention of early stroke recurrence.
Topics: Animals; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Recurrence; Stroke; Ticlopidine | 2014 |
A systematic review and critical assessment of 11 discordant meta-analyses on reduced-function CYP2C19 genotype and risk of adverse clinical outcomes in clopidogrel users.
Topics: Alleles; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Publication Bias; Ticlopidine; Treatment Outcome | 2015 |
Role of phenotypic and genetic testing in managing clopidogrel therapy.
Topics: Acute Coronary Syndrome; Adenosine; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Substitution; Genetic Testing; Humans; Piperazines; Polymorphism, Genetic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
Should clopidogrel be discontinued before coronary artery bypass grafting for patients with acute coronary syndrome? A systematic review and meta-analysis.
Topics: Acute Coronary Syndrome; Chi-Square Distribution; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Humans; Odds Ratio; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
[Dual platelet inhibitors in intensive care units].
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Germany; Guideline Adherence; Hemorrhage; Humans; Hypothermia, Induced; Intensive Care Units; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Risk Assessment; Shock, Cardiogenic; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antiviral Agents; Aspirin; Benzimidazoles; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Central Nervous System Stimulants; Clopidogrel; Dabigatran; Factor Xa Inhibitors; Genotype; Humans; Imidazolidines; Irinotecan; Isoenzymes; Methylphenidate; Oseltamivir; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Pyridines; Ticlopidine | 2014 |
Gene polymorphism of cytochrome P450 2C19*2 and clopidogrel resistance reflected by platelet function assays: a meta-analysis.
Topics: Aged; China; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Resistance; France; Humans; Middle Aged; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Republic of Korea; Ticlopidine | 2014 |
Intracerebral hemorrhage after pipeline embolization: Management of antiplatelet agents and the case for point-of-care testing--case reports and review of literature.
Topics: Aspirin; Cerebral Hemorrhage; Clinical Protocols; Clopidogrel; Drug Administration Schedule; Embolization, Therapeutic; Humans; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Receptors, Purinergic P2Y12; Ticlopidine | 2014 |
Wandering stent within the pulmonary circulation.
Topics: Aged, 80 and over; Angiography, Digital Subtraction; Anticoagulants; Arteriovenous Shunt, Surgical; Blood Vessel Prosthesis Implantation; Catheterization, Central Venous; Clopidogrel; Endovascular Procedures; Foreign-Body Migration; Graft Occlusion, Vascular; Heparin, Low-Molecular-Weight; Humans; Kidney Failure, Chronic; Male; Platelet Aggregation Inhibitors; Pulmonary Artery; Renal Dialysis; Stents; Ticlopidine; Treatment Outcome; Upper Extremity | 2014 |
Systematic reviews and meta-analyses for more profitable strategies in peripheral artery disease.
Topics: Adenosine; Aspirin; Asymptomatic Diseases; Cilostazol; Clopidogrel; Fibrinolytic Agents; Humans; Intermittent Claudication; Ischemia; Lower Extremity; Meta-Analysis as Topic; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Primary Prevention; Review Literature as Topic; Secondary Prevention; Stroke; Tetrazoles; Thrombosis; Ticagrelor; Ticlopidine | 2014 |
Efficacy and safety of adding clopidogrel to aspirin on stroke prevention among high vascular risk patients: a meta-analysis of randomized controlled trials.
Topics: Aspirin; Clopidogrel; Hemorrhage; Humans; Randomized Controlled Trials as Topic; Risk; Safety; Stroke; Ticlopidine | 2014 |
Efficacy of clopidogrel treatment and platelet responsiveness in peripheral arterial procedures.
Topics: Blood Platelets; Clopidogrel; Endovascular Procedures; Humans; Intermittent Claudication; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
[Antiplatelet drugs].
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
[Antiplatelet therapy for secondary prevention of cerebral infarction].
Topics: Aspirin; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Humans; Japan; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine | 2014 |
Decade in review--acute coronary syndromes: Successes and future objectives in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Anticoagulants; Antithrombins; Aspirin; Clopidogrel; Hemorrhage; Humans; Myocardial Revascularization; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2014 |
[Using ADP receptor antagonists in coronary heart disease and acute coronary syndrome].
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Early Medical Intervention; General Practice; Guideline Adherence; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Secondary Prevention; Stents; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
How to improve the concept of individualised antiplatelet therapy with P2Y12 receptor inhibitors--is an algorithm the answer?
Topics: Algorithms; Animals; Blood Platelets; Clopidogrel; Coronary Thrombosis; Decision Support Techniques; Drug Interactions; Drug Therapy, Combination; Hemorrhage; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2015 |
Managing antithrombotic therapy in patients with both atrial fibrillation and coronary heart disease.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Stroke; Ticlopidine; Vitamin K; Warfarin | 2014 |
Triple therapy for atrial fibrillation and percutaneous coronary intervention: a contemporary review.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Humans; Percutaneous Coronary Intervention; Randomized Controlled Trials as Topic; Ticlopidine; Vitamin K | 2014 |
Dual versus single antiplatelet therapy in patients undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Time Factors; Transcatheter Aortic Valve Replacement | 2015 |
Management of acute coronary syndrome in the hospital: a focus on ACCF/AHA guideline updates to oral antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine; Age Factors; Aspirin; Body Weight; Clopidogrel; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Quality of Health Care; Randomized Controlled Trials as Topic; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
Personalized genomes and cardiovascular disease.
Topics: Cardiovascular Diseases; Clopidogrel; Genome-Wide Association Study; Genome, Human; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pharmacogenetics; Platelet Aggregation Inhibitors; Precision Medicine; Risk Assessment; Ticlopidine | 2014 |
CYP2C19 genotype has a greater effect on adverse cardiovascular outcomes following percutaneous coronary intervention and in Asian populations treated with clopidogrel: a meta-analysis.
Topics: Alleles; Asian People; Clopidogrel; Coronary Occlusion; Cytochrome P-450 CYP2C19; Databases, Factual; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk; Stents; Thrombosis; Ticlopidine | 2014 |
Aspirin, clopidogrel, and the surgeon.
Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Practice Guidelines as Topic; Preoperative Care; Risk Assessment; Thienopyridines; Ticlopidine; Time Factors; Withholding Treatment | 2014 |
Outcome comparison of 600 mg versus 300 mg loading dose of clopidogrel for patients with ST-elevation myocardial infarction: a meta-analysis.
Topics: Aged; Clopidogrel; Dose-Response Relationship, Drug; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Resistance to antiplatelet drugs: what progress has been made?
Topics: Aspirin; Clopidogrel; Graft Occlusion, Vascular; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Precision Medicine; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Failure | 2014 |
Pharmacodynamic and clinical implications of switching between P2Y12 receptor antagonists: considerations for practice.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Substitution; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2014 |
Pretreatment with P2Y12 inhibitors in non-ST-segment-elevation acute coronary syndrome is clinically justified.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2014 |
Epidemiology, risk factors and management of cardiovascular diseases in IBD.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Clopidogrel; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammatory Bowel Diseases; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2015 |
[Added value of clopidogrel in cardiology and neurology].
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2014 |
Effect of addition of clopidogrel to aspirin on subdural hematoma: meta-analysis of randomized clinical trials.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Female; Hematoma, Subdural; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke, Lacunar; Ticlopidine | 2015 |
Comparative effectiveness review of antiplatelet agents in peripheral artery disease.
Topics: Aspirin; Clopidogrel; Comparative Effectiveness Research; Drug Therapy, Combination; Humans; Patient Safety; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2014 |
Reversing the effects of antiplatelet agents in the setting of intracranial hemorrhage: a look at the literature.
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Factor VIIa; Humans; Intracranial Hemorrhages; Platelet Aggregation Inhibitors; Platelet Transfusion; Recombinant Proteins; Ticlopidine; Treatment Outcome | 2015 |
Effect of high-dose clopidogrel according to CYP2C19*2 genotype in patients undergoing percutaneous coronary intervention- a systematic review and meta-analysis.
Topics: Alleles; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2015 |
Use of antiplatelet drugs after cardiac operations.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Drug Therapy, Combination; Graft Occlusion, Vascular; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2014 |
Aspirin plus clopidogrel as secondary prevention after stroke or transient ischemic attack: a systematic review and meta-analysis.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Recurrence; Secondary Prevention; Stroke; Ticlopidine | 2015 |
Clinical pharmacokinetics and pharmacodynamics of clopidogrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Humans; Polymorphism, Genetic; Precision Medicine; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2015 |
Management of low-dose aspirin and clopidogrel in clinical practice: a gastrointestinal perspective.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gastrointestinal Diseases; Helicobacter Infections; Helicobacter pylori; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2015 |
Meta-analysis appraising high maintenance dose clopidogrel in patients who underwent percutaneous coronary intervention with and without high on-clopidogrel platelet reactivity.
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Maintenance Chemotherapy; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2015 |
Prasugrel hydrochloride for the treatment of acute coronary syndromes.
Topics: Acute Coronary Syndrome; Animals; Aspirin; Clinical Trials, Phase III as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2015 |
Review of pharmacoeconomic evaluation of genotype-guided antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Risk Assessment; Thiophenes; Ticagrelor; Ticlopidine | 2015 |
Developments in Oral Antiplatelet Agents for the Treatment of Acute Coronary Syndromes: Clopidogrel, Prasugrel, and Ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
[Anticoagulant therapy in secondary prevention of coronary events].
Topics: Acute Coronary Syndrome; Administration, Oral; Anticoagulants; Aspirin; Benzimidazoles; beta-Alanine; Clinical Trials as Topic; Clopidogrel; Dabigatran; Hemorrhage; Humans; Morpholines; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyrazoles; Pyridones; Rivaroxaban; Secondary Prevention; Thiophenes; Ticlopidine; Warfarin | 2014 |
Pharmacogenomics of antiplatelet drugs.
Topics: Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2014 |
Appropriate prescribing and important drug interactions in older adults.
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Clopidogrel; Drug Combinations; Drug Interactions; Humans; Inappropriate Prescribing; Kidney; Liver; Medication Errors; Osteoporosis; Patient Compliance; Pharmacokinetics; Polypharmacy; Practice Guidelines as Topic; Practice Patterns, Physicians'; Proton Pump Inhibitors; Quinolones; Selective Serotonin Reuptake Inhibitors; Sulfadiazine; Ticlopidine; Trimethoprim | 2015 |
Meta-analysis of direct and indirect comparison of ticagrelor and prasugrel effects on platelet reactivity.
Topics: Adenosine; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Research Design; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
Dual antiplatelet therapy for coronary artery disease.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2015 |
Clinical evidence for oral antiplatelet therapy in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Intraoperative Care; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Thiophenes; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Meta-analysis of randomized controlled trials and adjusted observational results of use of clopidogrel, aspirin, and oral anticoagulants in patients undergoing percutaneous coronary intervention.
Topics: Administration, Oral; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine; Treatment Outcome | 2015 |
Is early hip fracture surgery safe for patients on clopidogrel? Systematic review, meta-analysis and meta-regression.
Topics: Aged; Aged, 80 and over; Anticoagulants; Blood Transfusion; Clopidogrel; Contraindications; Cross-Sectional Studies; Hip Fractures; Humans; Postoperative Hemorrhage; Postoperative Period; Risk Factors; Ticlopidine; Treatment Outcome | 2015 |
Antiplatelet drug resistance: Molecular insights and clinical implications.
Topics: Aspirin; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
P2Y12 receptor inhibitors for secondary prevention of ischemic stroke.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Hemorrhage; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Secondary Prevention; Stroke; Ticlopidine | 2015 |
CYP2C19 polymorphism and clinical outcomes among patients of different races treated with clopidogrel: A systematic review and meta-analysis.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Gene Frequency; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Racial Groups; Ticlopidine; Treatment Outcome | 2015 |
High maintenance dose of clopidogrel in patients with high on-treatment platelet reactivity after a percutaneous coronary intervention: a meta-analysis.
Topics: Cerebrovascular Disorders; Chi-Square Distribution; Clopidogrel; Drug Resistance; Heart Diseases; Hemorrhage; Humans; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2015 |
Novel oral P2Y12 inhibitor prasugrel vs. clopidogrel in patients with acute coronary syndrome: evidence based on 6 studies.
Topics: Acute Coronary Syndrome; Administration, Oral; Clopidogrel; Evidence-Based Medicine; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Risk Factors; Stroke; Thrombosis; Ticlopidine | 2015 |
Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary intervention.
Topics: Aged; Clopidogrel; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Male; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Assessment; Stents; Thrombosis; Ticlopidine | 2015 |
Comparison of Dual-antiplatelet Therapy to Mono-antiplatelet Therapy After Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis.
Topics: Aged; Aged, 80 and over; Aortic Valve Stenosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Stroke; Survival Analysis; Ticlopidine; Transcatheter Aortic Valve Replacement; Treatment Outcome; Ultrasonography | 2015 |
Thrombocytopenia in acute coronary syndromes: etiologies and proposed management.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Enzyme-Linked Immunosorbent Assay; Eptifibatide; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Platelet Count; Platelet Transfusion; Risk Assessment; Thrombocytopenia; Ticlopidine; Treatment Outcome | 2015 |
Dual Antiplatelet Therapy After Coronary Artery Bypass Grafting in the Setting of Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2015 |
Genotype-based clinical trials in cardiovascular disease.
Topics: Adrenergic beta-Antagonists; Anticoagulants; Biomarkers; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Forecasting; Genetic Markers; Genomics; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pharmacogenetics; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Sequence Analysis, DNA; Ticlopidine; Warfarin | 2015 |
Antiplatelet therapy following transcatheter aortic valve implantation.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aortic Valve Stenosis; Aspirin; Cardiac Catheterization; Clopidogrel; Drug Therapy, Combination; Female; Heart Valve Prosthesis Implantation; Hemorrhage; Humans; Male; Odds Ratio; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Switching from Clopidogrel to Prasugrel in patients undergoing PCI: A meta-analytic overview.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Substitution; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Genetically Determined Platelet Reactivity and Related Clinical Implications.
Topics: Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Humans; Membrane Glycoproteins; Mutation; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Ticlopidine | 2015 |
Building the Case for Clopidogrel as a World Health Organization Essential Medicine.
Topics: Cardiovascular Diseases; Clopidogrel; Drug Utilization; Drugs, Essential; Health Policy; Humans; Platelet Aggregation Inhibitors; Public Health; Ticlopidine; World Health Organization | 2015 |
Among antithrombotic agents, prasugrel, but not ticagrelor, is associated with reduced 30 day mortality in patients with ST-elevated myocardial infarction.
Topics: Adenosine; Clopidogrel; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Outcome Assessment, Health Care; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Survival Analysis; Ticagrelor; Ticlopidine | 2015 |
Meta-Analysis of Randomized Controlled Trials Comparing Risk of Major Adverse Cardiac Events and Bleeding in Patients With Prasugrel Versus Clopidogrel.
Topics: Clopidogrel; Coronary Artery Disease; Global Health; Hemorrhage; Humans; Incidence; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Ticlopidine | 2015 |
Management Strategies for Clopidogrel Hypersensitivity.
Topics: Clopidogrel; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Edoxaban versus placebo, aspirin, or aspirin plus clopidogrel for stroke prevention in atrial fibrillation. An indirect comparison analysis.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Drug Synergism; Drug Therapy, Combination; Embolism; Factor Xa Inhibitors; Humans; Mortality; Numbers Needed To Treat; Observational Studies as Topic; Platelet Aggregation Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Risk; Risk Assessment; Stroke; Thiazoles; Thrombophilia; Ticlopidine; Vitamin K | 2015 |
Practical experience with ticagrelor: an Australian and New Zealand perspective.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
Review of clopidogrel dose escalation in the current era of potent P2Y12 inhibitors.
Topics: Clopidogrel; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2015 |
New-onset atrial fibrillation after recent coronary stenting: Warfarin or non-vitamin K-antagonist oral anticoagulants to be added to aspirin and clopidogrel? A viewpoint.
Topics: Anticoagulants; Antithrombins; Aspirin; Atrial Fibrillation; Clopidogrel; Dabigatran; Drug Combinations; Factor Xa Inhibitors; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Stents; Thrombosis; Ticlopidine; Warfarin | 2015 |
Early P2Y12 inhibition in ST-segment elevation myocardial infarction: Bridging the gap.
Topics: Adenosine; Clopidogrel; Early Medical Intervention; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Meta-Analysis of Comparison of the Newer Oral P2Y12 Inhibitors (Prasugrel or Ticagrelor) to Clopidogrel in Patients With Non-ST-Elevation Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Clopidogrel; Dose-Response Relationship, Drug; Electrocardiography; Humans; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2015 |
Dual Antiplatelet Therapy of Clopidogrel and Aspirin in Secondary Prevention of Ischemic Stroke: Evidence and Indications.
Topics: Antiplatyhelmintic Agents; Aspirin; Brain Ischemia; Clopidogrel; Evidence-Based Medicine; Humans; Stroke; Ticlopidine | 2015 |
The pharmacogenetic control of antiplatelet response: candidate genes and CYP2C19.
Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Cardiovascular pharmacogenomics: current status and future directions.
Topics: Arrhythmias, Cardiac; Cardiovascular Agents; Clopidogrel; Genetic Variation; Genomics; Hematologic Agents; Heparin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pharmacogenetics; Ticlopidine; Warfarin | 2016 |
Evidence-Based Choice of P2Y12 Inhibitors in End Stage Renal Disease Patients: A Mini-Review.
Topics: Adenosine; Animals; Cardiovascular Diseases; Clopidogrel; Humans; Kidney Failure, Chronic; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
Obesity and Antiplatelets-Does One Size Fit All?
Topics: Clopidogrel; Drug Therapy, Combination; Humans; Obesity; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Ticagrelor, prasugrel, or clopidogrel in ST-segment elevation myocardial infarction: which one to choose?
Topics: Adenosine; Aspirin; Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
Clopidogrel and Genotyping.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Genotype; Humans; Omeprazole; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine | 2015 |
Current Evidence on Platelet P2Y12 Receptor Inhibitors: Is There Still a Role for Clopidogrel in 2015?
Topics: Acute Coronary Syndrome; Adenosine; Algorithms; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
Trends in pharmacological therapy following an acute coronary syndrome in Portugal: a systematic review.
Topics: Acute Coronary Syndrome; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiovascular Agents; Clopidogrel; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Secondary Prevention; Ticlopidine | 2016 |
Clopidogrel and Aspirin versus Aspirin Alone for Stroke Prevention: A Meta-Analysis.
Topics: Aspirin; Clopidogrel; Female; Hemorrhage; Humans; Male; Stroke; Ticlopidine | 2015 |
Antiplatelet therapies for secondary stroke prevention: an update on clinical and cost-effectiveness.
Topics: Aspirin; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2015 |
Antiplatelet therapy in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptor, PAR-1; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2015 |
Dual antiplatelet therapy with clopidogrel and aspirin for secondary stroke prevention.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Evidence-Based Medicine; Gastrointestinal Hemorrhage; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Public Health; Secondary Prevention; Stroke; Ticlopidine | 2015 |
Long-term dual antiplatelet therapy for secondary prevention of cardiovascular events in the subgroup of patients with previous myocardial infarction: a collaborative meta-analysis of randomized trials.
Topics: Adenosine; Adult; Aged; Clopidogrel; Drug Therapy, Combination; Humans; Long-Term Care; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Secondary Prevention; Ticagrelor; Ticlopidine; Treatment Outcome; Young Adult | 2016 |
Ticagrelor: a safe and effective approach for overcoming clopidogrel resistance in patients with stent thrombosis?
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Thrombosis; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2; Stents; Ticagrelor; Ticlopidine | 2016 |
Drug-drug interactions between clopidogrel and novel cardiovascular drugs.
Topics: Animals; Aspirin; Cardiovascular Agents; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Ticlopidine | 2015 |
Recurrent acute coronary syndrome and restenosis after percutaneous coronary intervention in a patient with idiopathic thrombocytopenic purpura: a case report and literature review.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Heparin; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purpura, Thrombocytopenic, Idiopathic; Recurrence; Ticlopidine | 2015 |
Vorapaxar for reduction of thrombotic cardiovascular events in myocardial infarction and peripheral artery disease.
Topics: Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Half-Life; Hemorrhage; Humans; Lactones; Myocardial Infarction; Myocardial Ischemia; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Receptor, PAR-1; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2015 |
Dual antiplatelet therapy with clopidogrel and aspirin after ischemic stroke: A review of the evidence.
Topics: Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Severity of Illness Index; Stroke; Ticlopidine; Time Factors | 2015 |
Efficacy and safety analysis of new P2Y12 inhibitors versus clopidogrel in patients with percutaneous coronary intervention: a meta-analysis.
Topics: Acute Coronary Syndrome; Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2015 |
Comparing the effectiveness and safety between triple antiplatelet therapy and dual antiplatelet therapy in type 2 diabetes mellitus patients after coronary stents implantation: a systematic review and meta-analysis of randomized controlled trials.
Topics: Acute Coronary Syndrome; Aspirin; Cilostazol; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stents; Tetrazoles; Thrombosis; Ticlopidine | 2015 |
The impact of switching P2Y12 receptor inhibitor therapy during index hospitalization: a systematic review.
Topics: Cardiovascular Diseases; Clopidogrel; Hemorrhage; Hospitalization; Humans; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2016 |
Clopidogrel, prasugrel, ticagrelor or vorapaxar in patients with renal impairment: do we have a winner?
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials as Topic; Clopidogrel; Comparative Effectiveness Research; Glomerular Filtration Rate; Hemorrhage; Humans; Lactones; Patient Selection; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Renal Insufficiency; Ticagrelor; Ticlopidine | 2015 |
Individual Proton Pump Inhibitors and Outcomes in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy: A Systematic Review.
Topics: Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Humans; Observational Studies as Topic; Odds Ratio; Patient Safety; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2015 |
On-treatment platelet reactivity: State of the art and perspectives.
Topics: Acute Coronary Syndrome; Adenosine; Age Factors; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Sex Factors; Stents; Thrombosis; Ticagrelor; Ticlopidine | 2016 |
Solid cancers after antiplatelet therapy: Confirmations, controversies, and challenges.
Topics: Adenosine; Animals; Anticarcinogenic Agents; Aspirin; Blood Platelets; Carcinogenicity Tests; Clopidogrel; Colonic Neoplasms; Drug Therapy, Combination; Female; Humans; Lactones; Male; Mice; Multicenter Studies as Topic; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Neoplastic Cells, Circulating; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Randomized Controlled Trials as Topic; Rivaroxaban; Sex Factors; Species Specificity; Ticagrelor; Ticlopidine; Time Factors | 2015 |
PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes.
Topics: Acute Coronary Syndrome; Aged; Amino Acid Substitution; Aryldialkylphosphatase; Clopidogrel; Female; Humans; Male; Middle Aged; Mutation, Missense; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Ticlopidine | 2016 |
Clopidogrel Response Variability: Review of the Literature and Practical Considerations.
Topics: Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Treatment Failure | 2016 |
Vascular risk levels affect the predictive value of platelet reactivity for the occurrence of MACE in patients on clopidogrel. Systematic review and meta-analysis of individual patient data.
Topics: Age Factors; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation; Platelet Function Tests; Predictive Value of Tests; Risk; Ticlopidine | 2016 |
Antiplatelet Agents in Cardiology: A Report on Aspirin, Clopidogrel, Prasugrel, and Ticagrelor.
Topics: Adenosine; Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticagrelor; Ticlopidine; Transcatheter Aortic Valve Replacement | 2016 |
Safety and Efficacy of Switching From Clopidogrel to Prasugrel in Patients Undergoing Percutaneous Coronary Intervention: A Study-level Meta-analysis From 15 Studies.
Topics: Clopidogrel; Drug Substitution; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Ticlopidine | 2016 |
Type 2 Diabetes and ADP Receptor Blocker Therapy.
Topics: Adenosine; Adenosine Monophosphate; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Diabetes Mellitus, Type 2; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
[Meta-analysis on the efficacy and adverse events of aspirin plus clopidogrel versus aspirin-monotherapy in patients with ischemic stroke or transient ischemic attack].
Topics: Aspirin; Clopidogrel; Databases, Factual; Drug Therapy, Combination; Hemorrhage; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk; Stroke; Ticlopidine; Treatment Outcome | 2015 |
Long-term antiplatelet therapy following myocardial infarction: implications of PEGASUS-TIMI 54.
Topics: Adenosine; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Recurrence; Risk Assessment; Risk Factors; Secondary Prevention; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Vorapaxar and diplopia: Possible off-target PAR-receptor mismodulation.
Topics: Animals; Aspirin; Clopidogrel; Diplopia; Drug Approval; Eye; Humans; Lactones; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Receptor, PAR-1; Receptors, Proteinase-Activated; Ticlopidine; United States; United States Food and Drug Administration | 2016 |
Reviewing the controversy surrounding pre-treatment with P2Y12 inhibitors in acute coronary syndrome patients.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2016 |
Exodontia in dual antiplatelet therapy: the evidence.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Oral Surgical Procedures; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Perioperative Management to Reduce Cardiovascular Events.
Topics: Adrenergic beta-Antagonists; Aged; Anesthesia; Anticoagulants; Arthroplasty, Replacement, Knee; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Contraindications; Coronary Disease; Disease Susceptibility; Heparin, Low-Molecular-Weight; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Male; Perioperative Care; Postoperative Complications; Postoperative Hemorrhage; Preanesthetic Medication; Risk Factors; Risk Reduction Behavior; Stress, Physiological; Surgical Procedures, Operative; Thrombophilia; Ticlopidine | 2016 |
Cardiovascular Pharmacogenomics--Implications for Patients With CKD.
Topics: Adrenergic beta-Antagonists; Anticoagulants; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Precision Medicine; Purinergic P2Y Receptor Antagonists; Renal Insufficiency, Chronic; Solute Carrier Proteins; Ticlopidine; Vitamin K Epoxide Reductases; Warfarin | 2016 |
Antiplatelet regimens in the long-term secondary prevention of transient ischaemic attack and ischaemic stroke: an updated network meta-analysis.
Topics: Aspirin; Cilostazol; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Hemorrhage; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke; Tetrazoles; Ticlopidine | 2016 |
Clopidogrel and hip fractures, is it safe? A systematic review and meta-analysis.
Topics: Blood Loss, Surgical; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Femoral Neck Fractures; Fracture Fixation; Humans; Odds Ratio; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2016 |
Dual antiplatelet therapy after stroke or transient ischaemic attack - how long to treat? The duration of aspirin plus clopidogrel in stroke or transient ischaemic attack: a systematic review and meta-analysis.
Topics: Aspirin; Clopidogrel; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Recurrence; Secondary Prevention; Stroke; Ticlopidine; Time Factors | 2016 |
When is the Best Time for the Second Antiplatelet Agent in Non-St Elevation Acute Coronary Syndrome?
Topics: Acute Coronary Syndrome; Clinical Trials as Topic; Clopidogrel; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Premedication; Ticlopidine; Time Factors | 2016 |
Antiplatelet therapy - a summary for the general physicians.
Topics: Adenosine; Clopidogrel; General Practitioners; Humans; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2016 |
The pharmacodynamics of antiplatelet compounds in thrombosis treatment.
Topics: Acute Coronary Syndrome; Animals; Aspirin; Blood Platelets; Clopidogrel; Drug Design; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Thrombosis; Ticlopidine | 2016 |
Oral P2Y12 Receptor Inhibitors in Hemodialysis Patients Undergoing Percutaneous Coronary Interventions: Current Knowledge and Future Directions.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Renal Dialysis; Ticagrelor; Ticlopidine | 2016 |
Intensified Antiplatelet Treatment Reduces Major Cardiac Events in Patients with Clopidogrel Low Response: A Meta-analysis of Randomized Controlled Trials.
Topics: Cardiovascular Diseases; Clopidogrel; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2016 |
Cytochrome allelic variants and clopidogrel metabolism in cardiovascular diseases therapy.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Gene Frequency; Humans; Inactivation, Metabolic; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2016 |
What is the optimal duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stent implantation?
Topics: Aspirin; Clopidogrel; Drug Administration Schedule; Drug-Eluting Stents; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine; Time Factors | 2016 |
Adherence to antiplatelet treatment with P2Y12 receptor inhibitors. Is there anything we can do to improve it? A systematic review of randomized trials.
Topics: Clopidogrel; Coronary Artery Disease; Humans; Medication Adherence; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Retrospective Studies; Ticlopidine | 2016 |
[Cholestasic toxic hepatitis due to clopidogrel in a patient with multiple conditions].
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Antiplatelet Management for Coronary Heart Disease: Advances and Challenges.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Ticlopidine; United States | 2016 |
Systematic review of the clinical impact of dual antiplatelet therapy discontinuation after acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine; Time Factors; Withholding Treatment | 2017 |
[Meta-analysis of the combination of warfarin and clopidogrel after coronary stenting in patients with indications for chronic oral anticoagulation].
Topics: Administration, Oral; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine; Warfarin | 2016 |
The Metabolism of Clopidogrel: CYP2C19 Is a Minor Pathway.
Topics: Animals; Citrus paradisi; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Humans; Platelet Aggregation Inhibitors; Signal Transduction; Ticlopidine | 2016 |
Optimal P2Y12 Inhibitor in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Network Meta-Analysis.
Topics: Adenosine; Antithrombins; Bayes Theorem; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Evidence-Based Medicine; Hirudins; Humans; Markov Chains; Monte Carlo Method; Network Meta-Analysis; Odds Ratio; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Recombinant Proteins; Risk Factors; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Pharmacokinetics and pharmacodynamics of oral P2Y12 inhibitors during the acute phase of a myocardial infarction: A systematic review.
Topics: Adenosine; Administration, Oral; Clopidogrel; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2016 |
[Subgroup analysis results of platelet inhibition trial in acute coronary syndrome patients (PLATO) who underwent intervention or medical treatment].
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2013 |
[Switching from clopidogrel to prasugrel: Efficacy and safety data].
Topics: Clopidogrel; Drug Substitution; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2015 |
Management of Antiplatelet Allergy After Cardiac Stenting.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Drug Eruptions; Drug-Eluting Stents; Female; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prednisone; Stents; Thrombosis; Ticlopidine | 2016 |
Cangrelor for the management and prevention of arterial thrombosis.
Topics: Adenosine Monophosphate; Administration, Intravenous; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticlopidine | 2016 |
Platelet function testing as a biomarker for efficacy of antiplatelet drugs.
Topics: Biomarkers; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2016 |
Comparison of current platelet functional tests for the assessment of aspirin and clopidogrel response. A review of the literature.
Topics: Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2016 |
Clopidogrel-Proton Pump Inhibitor Drug-Drug Interaction and Risk of Adverse Clinical Outcomes Among PCI-Treated ACS Patients: A Meta-analysis.
Topics: Acute Coronary Syndrome; Clopidogrel; Combined Modality Therapy; Drug Interactions; Humans; Percutaneous Coronary Intervention; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine; Treatment Outcome | 2016 |
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with lateral medullary syndrome: case report and literature review.
Topics: Aged; Antipyrine; Arginine; Clopidogrel; Diffusion Magnetic Resonance Imaging; Diuretics; Edaravone; Free Radical Scavengers; Furosemide; Humans; Hyponatremia; Inappropriate ADH Syndrome; Lateral Medullary Syndrome; Male; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Ticlopidine | 2016 |
Genetic polymorphisms influence on the response to clopidogrel in peripheral artery disease patients following percutaneous transluminal angioplasty.
Topics: Aged; Angioplasty; Atherosclerosis; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Graft Occlusion, Vascular; Humans; Lower Extremity; Male; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Spain; Ticlopidine; Treatment Outcome | 2016 |
Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Clopidogrel; Databases, Factual; Gastrointestinal Hemorrhage; Humans; Incidence; Intracranial Hemorrhages; Observational Studies as Topic; Odds Ratio; Risk; Ticlopidine | 2016 |
Use of prasugrel in the setting of clopidogrel hypersensitivity: Case report and systematic review of the literature.
Topics: Adult; Clopidogrel; Coronary Artery Disease; Drug Hypersensitivity; Drug Substitution; Drug-Eluting Stents; Humans; Male; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2016 |
Pharmacogenetics in Oral Antithrombotic Therapy.
Topics: Administration, Oral; Clopidogrel; Fibrinolytic Agents; Genotype; Humans; Polymorphism, Genetic; Precision Medicine; Ticlopidine; Warfarin | 2016 |
Dual antiplatelet therapy for secondary stroke prevention: Use of clopidogrel and acetylsalicylic acid after noncardioembolic ischemic stroke.
Topics: Aged, 80 and over; Aspirin; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Female; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2016 |
A systematic review of anti-thrombotic therapy in epistaxis.
Topics: Anticoagulants; Antifibrinolytic Agents; Aspirin; Clopidogrel; Dabigatran; Disease Management; Epistaxis; Humans; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Risk Assessment; Rivaroxaban; Ticlopidine; Tranexamic Acid; Warfarin | 2016 |
Aspirin, Plavix, and Other Antiplatelet Medications: What the Oral and Maxillofacial Surgeon Needs to Know.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Humans; Medication Therapy Management; Oral Surgical Procedures; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Long-Term P2Y12-Receptor Antagonists in Post-Myocardial Infarction Patients: Facing a New Trilemma?
Topics: Adenosine; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stroke; Ticagrelor; Ticlopidine; Time Factors | 2016 |
Proton Pump Inhibitors in Cardiovascular Disease: Drug Interactions with Antiplatelet Drugs.
Topics: Adenosine; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Administration Schedule; Drug Dosage Calculations; Drug Interactions; Esomeprazole; Gastrointestinal Hemorrhage; Gene Expression; Humans; Hydrogen-Ion Concentration; Peptic Ulcer; Prasugrel Hydrochloride; Proton Pump Inhibitors; Purinergic Antagonists; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2017 |
[Direct oral anticoagulants in cardiology].
Topics: Administration, Oral; Anticoagulants; Aspirin; Cardiology; Cardiovascular Diseases; Clopidogrel; Fibrinolytic Agents; Heparin; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2016 |
Association between CYP3A5 polymorphisms and the risk of adverse events in patients undergoing clopidogrel therapy: Meta-analysis.
Topics: Clopidogrel; Cytochrome P-450 CYP3A; Drug Resistance; Genetic Association Studies; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2016 |
Safety and efficacy of IIb/IIIa inhibitors in combination with highly active oral antiplatelet regimens in acute coronary syndromes: A meta-analysis of pivotal trials.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Clopidogrel; Combined Modality Therapy; Comorbidity; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
Immature Platelets: Clinical Relevance and Research Perspectives.
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Clopidogrel; Humans; Megakaryocytes; RNA, Messenger; Ticlopidine | 2016 |
Prasugrel hydrochloride for the treatment of acute coronary syndrome patients.
Topics: Acute Coronary Syndrome; Administration, Oral; Aspirin; Blood Platelets; Clopidogrel; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thrombosis; Ticlopidine | 2016 |
Contemporary management of ST-segment elevation myocardial infarction.
Topics: Analgesics; Clopidogrel; Humans; Morphine; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; ST Elevation Myocardial Infarction; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Cardiovascular pharmacogenetics: a promise for genomically-guided therapy and personalized medicine.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Genetic Predisposition to Disease; Genetic Variation; Genome, Human; Genomics; Humans; Pharmacogenetics; Precision Medicine; Ticlopidine; Warfarin | 2017 |
Pharmacokinetics and pharmacodynamics of ticagrelor in the treatment of cardiac ischemia.
Topics: Acute Coronary Syndrome; Adenosine; Animals; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticagrelor; Ticlopidine; Time Factors | 2016 |
Current controversies in the use of aspirin and ticagrelor for the treatment of thrombotic events.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticagrelor; Ticlopidine | 2016 |
Risk and Benefits of Triple Therapy in Patients Undergoing Coronary Stent Implantation Requiring Oral Anticoagulation: A Meta-Analysis of 16 Studies.
Topics: Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk; Stents; Ticlopidine; Warfarin | 2016 |
Genetic Polymorphisms and Clopidogrel Efficacy for Acute Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis.
Topics: Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Databases, Factual; Genotype; Humans; Ischemic Attack, Transient; Polymorphism, Genetic; Risk; Stroke; Ticlopidine | 2017 |
A critical reappraisal of aspirin for secondary prevention in patients with ischemic heart disease.
Topics: Adenosine; Antithrombins; Aspirin; Clopidogrel; Drug Therapy, Combination; Evidence-Based Medicine; Factor Xa Inhibitors; Hemorrhage; History, 20th Century; History, 21st Century; History, Ancient; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Secondary Prevention; Ticagrelor; Ticlopidine | 2016 |
Discontinuation of Plavix
Topics: Blood Loss, Surgical; Clopidogrel; Hip Fractures; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Assessment; Ticlopidine; Time Factors; Withholding Treatment | 2016 |
Genetic Determinants of P2Y
Topics: Acute Coronary Syndrome; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Polymorphism, Single Nucleotide; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticlopidine | 2017 |
Meta-analysis of clopidogrel pretreatment in acute coronary syndrome patients undergoing invasive strategy.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Ticlopidine | 2017 |
Meta-analysis of Comparison of the Newer P2Y12 Inhibitors (Oral Preparation or Intravenous) to Clopidogrel in Patients With Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Administration, Intravenous; Administration, Oral; Clopidogrel; Humans; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticlopidine | 2017 |
Optimal pediatric dosing of anti-platelet agents for pipeline stent embolization -a case report and review of the literature.
Topics: Adolescent; Aspirin; Bone Neoplasms; Cerebral Hemorrhage; Clopidogrel; Embolization, Therapeutic; Female; Humans; Osteoblastoma; Platelet Aggregation Inhibitors; Ticlopidine | 2017 |
Spontaneous coronary artery dissection: Case report and review of the literature.
Topics: Acute Coronary Syndrome; Adrenergic beta-1 Receptor Antagonists; Adult; Aspirin; Atorvastatin; Clopidogrel; Coronary Angiography; Coronary Vessel Anomalies; Echocardiography; Electrocardiography; Female; Humans; Metoprolol; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Diseases | 2016 |
East Asian perspective on the interaction between proton pump inhibitors and clopidogrel.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anticoagulants; Asia, Eastern; Asian People; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Dexlansoprazole; Drug Interactions; Drug Therapy, Combination; Gastroesophageal Reflux; Gastrointestinal Hemorrhage; Humans; Isoenzymes; Pantoprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Rabeprazole; Ticlopidine | 2017 |
Cancer Event Rate and Mortality with Thienopyridines: A Systematic Review and Meta-Analysis.
Topics: Aspirin; Clopidogrel; Humans; Incidence; Neoplasms; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Risk; Thienopyridines; Ticlopidine | 2017 |
Is the concomitant use of clopidogrel and Proton Pump Inhibitors still associated with increased adverse cardiovascular outcomes following coronary angioplasty?: a systematic review and meta-analysis of recently published studies (2012 - 2016).
Topics: Aged; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2017 |
A comparison of cangrelor, prasugrel, ticagrelor, and clopidogrel in patients undergoing percutaneous coronary intervention: A network meta-analysis.
Topics: Adenosine; Adenosine Monophosphate; Clopidogrel; Humans; Myocardial Infarction; Network Meta-Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
Proton pump inhibitors: Risks of long-term use.
Topics: Calcium; Cardiovascular Diseases; Clopidogrel; Dementia; Drug Interactions; Fractures, Bone; Gastrointestinal Neoplasms; Humans; Intestinal Absorption; Kidney Diseases; Pneumonia; Proton Pump Inhibitors; Risk; Ticlopidine; Time Factors; Vitamins | 2017 |
Three, six, or twelve months of dual antiplatelet therapy after DES implantation in patients with or without acute coronary syndromes: an individual patient data pairwise and network meta-analysis of six randomized trials and 11 473 patients.
Topics: Acute Coronary Syndrome; Analysis of Variance; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Artery Disease; Death, Sudden, Cardiac; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Assessment; Stroke; Ticlopidine; Treatment Outcome | 2017 |
Oral antiplatelet agents for the management of acute coronary syndromes: A review for nurses and allied healthcare professionals.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Arylsulfonates; Aspirin; Clopidogrel; Disease Management; Humans; Nurse Practitioners; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticagrelor; Ticlopidine | 2017 |
Potential Usefulness of Clopidogrel Pharmacogenetics in Cerebral Endovascular Procedures and Carotid Artery Stenting.
Topics: Carotid Artery Diseases; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance, Neoplasm; Endovascular Procedures; Humans; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2017 |
Obesity and Inflammation and Altered Clopidogrel Pharmacokinetics and Pharmacodynamics.
Topics: Cardiovascular Diseases; Clopidogrel; Humans; Inflammation; Obesity; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2017 |
Monitoring Antiplatelet Therapy.
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Monitoring; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Reproducibility of Results; Thrombosis; Ticlopidine | 2017 |
Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: a pooled analysis of individual-patient datasets from clinical trials.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Hemorrhage; Humans; Kaplan-Meier Estimate; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Assessment; Stents; Ticlopidine; Treatment Outcome | 2017 |
Does percutaneous coronary stent implantation increase platelet reactivity?
Topics: Blood Platelets; Clopidogrel; Coronary Disease; Humans; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine | 2017 |
Pharmacokinetic and Pharmacodynamic Responses to Clopidogrel: Evidences and Perspectives.
Topics: Acute Coronary Syndrome; Clopidogrel; Comorbidity; Drug Interactions; Humans; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Severity of Illness Index; Socioeconomic Factors; Ticlopidine; Treatment Outcome | 2017 |
Meta-analysis of effects of ABCB1 polymorphisms on clopidogrel response among patients with coronary artery disease.
Topics: Asian People; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Coronary Artery Disease; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Ticlopidine | 2017 |
Bleeding risk of antiplatelet drugs compared with oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-analysis.
Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Cohort Studies; Female; Hemorrhage; Humans; Intracranial Hemorrhages; Male; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk; Stroke; Ticlopidine; Treatment Outcome; Vitamin K; Warfarin | 2017 |
High on treatment platelet reactivity to aspirin and clopidogrel in ischemic stroke: A systematic review and meta-analysis.
Topics: Aspirin; Blood Platelets; Brain Ischemia; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2017 |
A Meta-analysis of the Impact of Aspirin, Clopidogrel, and Dual Antiplatelet Therapy on Bleeding Complications in Noncardiac Surgery.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk Factors; Surgical Procedures, Operative; Ticlopidine | 2018 |
Antithrombotic strategies for preventing long-term major adverse cardiovascular events in patients with non-valvular atrial fibrillation who undergo percutaneous coronary intervention.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 2017 |
[Management of the bleeding risk associated with antiplatelet agents].
Topics: Adenosine; Aspirin; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticagrelor; Ticlopidine | 2017 |
How I use laboratory monitoring of antiplatelet therapy.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Drug Monitoring; Humans; Male; Middle Aged; Molecular Targeted Therapy; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2017 |
The Efficacy and Safety of 3 Types of Interventions for Stroke Prevention in Patients With Cardiovascular and Cerebrovascular Diseases: A Network Meta-analysis.
Topics: Anticoagulants; Aspirin; Bayes Theorem; Cardiovascular Diseases; Clopidogrel; Dabigatran; Dipyridamole; Hemorrhage; Humans; Odds Ratio; Pyrazoles; Pyridines; Pyridones; Randomized Controlled Trials as Topic; Thiazoles; Ticlopidine; Treatment Outcome; Warfarin | 2017 |
Individualized dual antiplatelet therapy based on platelet function testing in patients undergoing percutaneous coronary intervention: a meta-analysis of randomized controlled trials.
Topics: Acute Coronary Syndrome; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Hemorrhage; Humans; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Treatment Outcome | 2017 |
Updating the Evidence of the Interaction Between Clopidogrel and CYP2C19-Inhibiting Selective Serotonin Reuptake Inhibitors: A Cohort Study and Meta-Analysis.
Topics: Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Databases, Pharmaceutical; Drug Interactions; Female; Humans; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors; Ticlopidine | 2017 |
[Antiplatelet agents and transfusion].
Topics: Adenosine; Antidotes; Aspirin; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Transfusion; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk; Ticagrelor; Ticlopidine | 2017 |
[Impact of different antithrombotic therapy strategy on prognosis in coronary heart disease patients combining with atrial fibrillation: a meta analysis].
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Disease; Fibrinolytic Agents; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Randomized Controlled Trials as Topic; Stroke; Ticlopidine; Warfarin | 2017 |
Duration of dual antiplatelet therapy after coronary stent insertion: Does the benefit of extended therapy outweigh the risk?
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Male; Meta-Analysis as Topic; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Time Factors | 2016 |
Role of genetic testing in patients undergoing percutaneous coronary intervention.
Topics: Adenosine; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2018 |
Personalizing antiplatelet prescribing using genetics for patients undergoing percutaneous coronary intervention.
Topics: Biomarkers, Pharmacological; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Ticlopidine | 2017 |
Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis.
Topics: Adenosine; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Proportional Hazards Models; Recurrence; Secondary Prevention; Stroke; Ticagrelor; Ticlopidine; Treatment Failure | 2017 |
Dual Versus Single Antiplatelet Regimen With or Without Anticoagulation in Transcatheter Aortic Valve Replacement: Indirect Comparison and Meta-analysis.
Topics: Anticoagulants; Aortic Valve; Aortic Valve Stenosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Heart Valve Prosthesis; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Transcatheter Aortic Valve Replacement; Treatment Outcome | 2018 |
A Primer on Bleeding Risk and Management Strategies of Newer Oral Anti Platelet Agents in Cardiovascular Disease.
Topics: Adenosine; Administration, Oral; Aspirin; Cardiovascular Diseases; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Thrombosis; Ticagrelor; Ticlopidine | 2016 |
Overcoming Clopidogrel Resistance: Three Promising Novel Antiplatelet Drugs Developed in China.
Topics: Acute Coronary Syndrome; China; Clopidogrel; Drug Discovery; Drug Resistance; Humans; Phenylacetates; Platelet Aggregation Inhibitors; Prodrugs; Thiophenes; Ticlopidine | 2017 |
Risk of Early Adverse Events After Clopidogrel Discontinuation in Patients Undergoing Short-Term Dual Antiplatelet Therapy: An Individual Participant Data Analysis.
Topics: Aged; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Perioperative management of antithrombotic therapy in patients receiving cardiovascular implantable electronic devices: a network meta-analysis.
Topics: Administration, Oral; Anticoagulants; Aspirin; Cardiac Resynchronization Therapy Devices; Cause of Death; Clopidogrel; Defibrillators, Implantable; Evidence-Based Medicine; Female; Humans; Injections, Subcutaneous; Male; Network Meta-Analysis; Observational Studies as Topic; Pacemaker, Artificial; Perioperative Care; Prognosis; Risk Assessment; Survival Analysis; Thromboembolism; Ticlopidine; Treatment Outcome; Warfarin | 2017 |
Developments in the synthesis of the antiplatelet and antithrombotic drug (S)-clopidogrel.
Topics: Animals; Chemistry Techniques, Synthetic; Clopidogrel; Drug Discovery; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Stereoisomerism; Ticlopidine | 2017 |
Review of aspirin and clopidogrel resistance in peripheral arterial disease.
Topics: Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Genotype; Humans; Peripheral Arterial Disease; Pharmacogenomic Variants; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticlopidine; Treatment Outcome | 2017 |
Comparison of treatment outcomes of ticagrelor and clopidogrel among patients undergoing percutaneous coronary intervention: A meta-analysis.
Topics: Adenosine; Adult; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
International Expert Consensus on Switching Platelet P2Y
Topics: Administration, Intravenous; Administration, Oral; Aspirin; Clopidogrel; Consensus; Drug Substitution; Humans; Internationality; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2017 |
Recurrent Ischemic Stroke: Strategies for Prevention.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; United States | 2017 |
The role of prasugrel in the management of acute coronary syndromes: a systematic review.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thrombosis; Ticlopidine | 2017 |
Cangrelor in Percutaneous Coronary Intervention: Current Status and Perspectives.
Topics: Adenosine Monophosphate; Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2018 |
Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2017 |
A Review of Analytical Methods for the determination of Clopidogrel in Pharmaceuticals and Biological Matrices.
Topics: Chromatography, High Pressure Liquid; Clopidogrel; Humans; Molecular Conformation; Receptors, Purinergic P2Y12; Spectrophotometry, Ultraviolet; Ticlopidine | 2018 |
Influence of proton pump inhibitors on clinical outcomes in coronary heart disease patients receiving aspirin and clopidogrel: A meta-analysis.
Topics: Aspirin; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2018 |
Association between P2RY12 gene polymorphisms and adverse clinical events in coronary artery disease patients treated with clopidogrel: A systematic review and meta-analysis.
Topics: Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Mutation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y12; Research Design; Ticlopidine | 2018 |
Role of CYP2C19 genotype testing in clinical use of clopidogrel: is it really useful?
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Ticlopidine | 2018 |
Aspirin plus dipyridamole has the highest surface under the cumulative ranking curves (SUCRA) values in terms of mortality, intracranial hemorrhage, and adverse event rate among 7 drug therapies in the treatment of cerebral infarction.
Topics: Aspirin; Cerebral Infarction; Cilostazol; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Hematologic Agents; Humans; Intracranial Hemorrhages; Tetrazoles; Ticlopidine; Warfarin | 2018 |
Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders.
Topics: Aspirin; Blood Platelets; Clopidogrel; Female; Hemorrhage; Humans; Male; P-Selectin; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Ticlopidine | 2018 |
Antithrombotic therapy in patients with non-valvular atrial fibrillation undergoing percutaneous coronary intervention: should we change our practice after the PIONEER AF-PCI and RE-DUAL PCI trials?
Topics: Administration, Oral; Anticoagulants; Atrial Fibrillation; Clopidogrel; Drug Administration Schedule; Evidence-Based Medicine; Fibrinolytic Agents; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2018 |
Dual and triple antithrombotic therapies: current patterns of practice and controversies.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Patient Safety; Percutaneous Coronary Intervention; Ticlopidine; Treatment Outcome; Warfarin | 2018 |
Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a systematic review and meta-analysis.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Intracranial Hemorrhages; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2018 |
Continuation versus discontinuation of antiplatelet therapy for bleeding and ischaemic events in adults undergoing non-cardiac surgery.
Topics: Adult; Aspirin; Cause of Death; Clopidogrel; Elective Surgical Procedures; Hemorrhage; Humans; Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Withholding Treatment | 2018 |
[Anti-Thrombotic Treatment of Patients with Peripheral Artery Disease (PAD)].
Topics: Administration, Oral; Anticoagulants; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Germany; Guideline Adherence; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Postoperative Care; Rivaroxaban; Secondary Prevention; Ticlopidine; Veins | 2018 |
Triple therapy: worth the risk?
Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Synergism; Drug Therapy, Combination; Factor Xa Inhibitors; Hemorrhage; Humans; Mortality; Multicenter Studies as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Rivaroxaban; Stents; Stroke; Thrombophilia; Ticlopidine | 2018 |
Choosing between ticagrelor and clopidogrel following percutaneous coronary intervention: A systematic review and Meta-Analysis (2007-2017).
Topics: Adenosine; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Period; Ticagrelor; Ticlopidine | 2018 |
Monotherapy with a P2Y
Topics: Aged; Aspirin; Atherosclerosis; Cerebrovascular Disorders; Clopidogrel; Coronary Disease; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Assessment; Secondary Prevention; Stroke; Ticagrelor; Ticlopidine | 2020 |
[The relationship between the combined use of various proton pump inhibitors with antiplatelet drugs and the risk of cardiovascular complications].
Topics: Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2019 |
Risk of major adverse cardiovascular events for concomitant use of clopidogrel and proton pump inhibitors in patients inheriting CYP2C19 loss-of-function alleles: meta-analysis.
Topics: Alleles; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2021 |
Efficacy and safety of proton pump inhibitors combined with clopidogrel in patients undergoing percutaneous coronary intervention: a meta-analysis.
Topics: Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2021 |
Outcomes of a multi-ethnic Asian population on combined treatment with clopidogrel and omeprazole in 12,440 patients.
Topics: Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Ethnicity; Humans; Myocardial Infarction; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Stroke; Ticlopidine | 2021 |
Influence of individual proton pump inhibitors on clinical outcomes in patients receiving clopidogrel following percutaneous coronary intervention.
Topics: Clopidogrel; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Ticlopidine; Treatment Outcome | 2021 |
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Pharmacogenetics; Platelet Aggregation Inhibitors; Prodrugs; Ticlopidine | 2022 |
Platelet reactivity testing in peripheral artery disease.
Topics: Blood Platelets; Clopidogrel; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2022 |
Ideal P2Y12 Inhibitor in Acute Coronary Syndrome: A Review and Current Status.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticagrelor; Ticlopidine; Treatment Outcome | 2022 |
The role of
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Ischemic Attack, Transient; Ischemic Stroke; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2022 |
Navigating Antiplatelet Treatment Options for Stroke: Evidence-Based and Pragmatic Strategies.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Ischemic Stroke; Platelet Aggregation Inhibitors; Stroke; Ticagrelor; Ticlopidine | 2022 |
A Systematic Review of Clopidogrel Resistance in Vascular Surgery: Current Perspectives and Future Directions.
Topics: Cerebrovascular Disorders; Clopidogrel; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Vascular Surgical Procedures | 2023 |
Genotyping genetic variants of
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2022 |
Hypoglycemia as a potential risk for patients taking clopidogrel: A systematic review and meta-analysis.
Topics: Aged; Aspirin; Clopidogrel; Humans; Hypoglycemia; Platelet Aggregation Inhibitors; Ticlopidine | 2023 |
1563 trial(s) available for ticlopidine and clopidogrel
| Article | Year |
|---|---|
Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase.
Topics: Adenosine; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adult; Binding Sites; Blood Platelets; Clopidogrel; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Purinergic; Thionucleotides; Thrombin; Ticlopidine | 1992 |
Clopidogrel--a platelet inhibitor which inhibits thrombogenesis in non-anticoagulated human blood independently of the blood flow conditions.
Topics: Adult; Anticoagulants; Blood Flow Velocity; Clopidogrel; Fibrin; Fibrinopeptide A; Hematologic Tests; Humans; Male; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Count; Thrombosis; Ticlopidine | 1994 |
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee.
Topics: Adult; Arteriosclerosis; Aspirin; Brain Ischemia; Clopidogrel; Cohort Studies; Double-Blind Method; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Myocardial Ischemia; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 1996 |
Platelet anti-aggregating activity and tolerance of clopidogrel in atherosclerotic patients.
Topics: Adult; Aged; Arteriosclerosis; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1996 |
[Recent antithrombotic gold standard?].
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 1997 |
[New analysis of CAPRIE (Clopidogrel vs Aspirin in Patients at Risk of Ischemic Events) shows: myocardial infarct most effectively prevented in the clopidogrel group].
Topics: Clopidogrel; Humans; Myocardial Ischemia; Placebos; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 1998 |
[Antithrombotic agents in unstable angina. Review of clinical trials].
Topics: Angina, Unstable; Aspirin; Clopidogrel; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Hirudin Therapy; Humans; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 1998 |
The results of CAPRIE, IST and CAST. Clopidogrel vs. Aspirin in Patients at Risk of Ischaemic Events. International Stroke Trial. Chinese Acute Stroke Trial.
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Double-Blind Method; Humans; Ischemia; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 1998 |
Results of the CAPRIE trial: efficacy and safety of clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events.
Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Follow-Up Studies; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Treatment Outcome | 1998 |
Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Thrombosis; Diarrhea; Drug Eruptions; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Neutropenia; Platelet Aggregation Inhibitors; Postoperative Complications; Safety; Stents; Ticlopidine; Treatment Outcome | 1999 |
Effect of clopidogrel on naproxen-induced gastrointestinal blood loss in healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bleeding Time; Clopidogrel; Double-Blind Method; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Male; Naproxen; Occult Blood; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
The CAPRIE trial: culmination of the preregistration program for clopidogrel. Clopidogrel versus aspirin in patients at risk of ischaemic events. Clopidogrel versus aspirin in patients at risk of ischaemic events.
Topics: Adult; Clopidogrel; Double-Blind Method; Female; Humans; Male; Patient Selection; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Single-dose pharmacodynamics of clopidogrel.
Topics: Administration, Oral; Adult; Aspirin; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Repeated-dose pharmacodynamics of clopidogrel in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Clopidogrel; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Clopidogrel loading dose regimens: kinetic profile of pharmacodynamic response in healthy subjects.
Topics: Adult; Bleeding Time; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; Kinetics; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Single-Blind Method; Ticlopidine | 1999 |
Long-term activity of clopidogrel: a three-month appraisal in healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Bleeding Time; Clopidogrel; Dose-Response Relationship, Drug; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 1999 |
Pharmacokinetics of clopidogrel.
Topics: Administration, Oral; Adolescent; Adult; Bleeding Time; Carboxylic Acids; Clopidogrel; Dose-Response Relationship, Drug; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Pharmacokinetic profile of 14C-labeled clopidogrel.
Topics: Administration, Oral; Adult; Area Under Curve; Carbon Radioisotopes; Clopidogrel; Drug Administration Schedule; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Clopidogrel and drug metabolism: absence of effect on hepatic enzymes in healthy volunteers.
Topics: Adolescent; Adult; Bleeding Time; Clopidogrel; Double-Blind Method; Enzyme Induction; Humans; Liver; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Clopidogrel antiplatelet activity is independent of age and presence of atherosclerosis.
Topics: Adolescent; Adult; Age Factors; Aged; Arteriosclerosis; Bleeding Time; Clopidogrel; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Clopidogrel bioavailability: absence of influence of food or antacids.
Topics: Adolescent; Adult; Aged; Aluminum Hydroxide; Antacids; Biological Availability; Clopidogrel; Cross-Over Studies; Drug Combinations; Eating; Fasting; Humans; Magnesium Hydroxide; Male; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Clopidogrel, a novel antiplatelet agent, and digoxin: absence of pharmacodynamic and pharmacokinetic interaction.
Topics: Adolescent; Adult; Clopidogrel; Digoxin; Drug Combinations; Drug Interactions; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Clopidogrel compatibility with concomitant cardiac co-medications: a study of its interactions with a beta-blocker and a calcium uptake antagonist.
Topics: Adrenergic beta-Antagonists; Adult; Arterial Occlusive Diseases; Atenolol; Calcium Channel Blockers; Clopidogrel; Coronary Disease; Cross-Over Studies; Double-Blind Method; Drug Incompatibility; Female; Humans; Male; Middle Aged; Nifedipine; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Prolonged heparin administration during clopidogrel treatment in healthy subjects.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Heparin; Humans; Infusions, Intravenous; Male; Partial Thromboplastin Time; Ticlopidine | 1999 |
Clopidogrel does not affect the pharmacokinetics of theophylline.
Topics: Administration, Oral; Adult; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Drug Interactions; Humans; Male; Microsomes, Liver; Platelet Aggregation; Platelet Aggregation Inhibitors; Theophylline; Ticlopidine | 1999 |
Clopidogrel-rt-PA-heparin combination in the treatment of acute myocardial infarction.
Topics: Administration, Oral; Adult; Aged; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Heparin; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recombinant Proteins; Recurrence; Ticlopidine; Tissue Plasminogen Activator | 1999 |
Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and Investigators. Clopidogrel versus aspirin in patients at risk of ischaemic events.
Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Double-Blind Method; Gastrointestinal Diseases; Hemorrhage; Humans; Myocardial Infarction; Neutropenia; Platelet Aggregation Inhibitors; Stroke; Thrombocytopenia; Ticlopidine; Time Factors; Treatment Outcome | 1999 |
Clopidogrel as adjunctive antiplatelet therapy during coronary stenting.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Combination; Female; Hospital Mortality; Humans; Length of Stay; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Safety; Stents; Ticlopidine; Treatment Outcome | 1999 |
Clopidogrel versus ticlopidine after intracoronary stent placement.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Combination; Female; Hospital Mortality; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Safety; Secondary Prevention; Stents; Ticlopidine; Time Factors; Treatment Outcome | 1999 |
Antiplatelet activity of clopidogrel in coronary artery bypass graft surgery patients.
Topics: Adenosine Diphosphate; Adult; Bleeding Time; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine; Treatment Outcome | 1999 |
[Acute coronary syndrome, stent and cardiac insufficiency. Advances in thrombosis prevention].
Topics: Acute Disease; Clopidogrel; Coronary Disease; Coronary Thrombosis; Coumarins; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after the placement of coronary-artery stents.
Topics: Aged; Aspirin; Clopidogrel; Coronary Thrombosis; Coronary Vessels; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine; Treatment Outcome | 2000 |
Cirrhosis does not affect the pharmacokinetics and pharmacodynamics of clopidogrel.
Topics: Adult; Area Under Curve; Case-Control Studies; Clopidogrel; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Platelet Aggregation Inhibitors; Skin Diseases; Ticlopidine; Time Factors | 2000 |
[ASS or clopidogrel? In high vascular risk it is best to give both].
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2000 |
Early potent antithrombotic effect with combined aspirin and a loading dose of clopidogrel on experimental arterial thrombogenesis in humans.
Topics: Adult; Arteries; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Time Factors | 2000 |
Gastroduodenal tolerance of 75 mg clopidogrel versus 325 mg aspirin in healthy volunteers. A gastroscopic study.
Topics: Adult; Aspirin; Clopidogrel; Double-Blind Method; Drug Hypersensitivity; Gastric Mucosa; Gastritis; Gastroscopy; Humans; Intestinal Mucosa; Male; Patient Compliance; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2000 |
Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin. CAPRIE investigators.
Topics: Aspirin; Brain Ischemia; Cause of Death; Clopidogrel; Confidence Intervals; Double-Blind Method; Female; Hemorrhage; Hospitalization; Humans; Incidence; Ischemia; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Probability; Prognosis; Proportional Hazards Models; Risk Assessment; Secondary Prevention; Survival Analysis; Ticlopidine | 2000 |
Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting : the clopidogrel aspirin stent international cooperative study (CLAS
Topics: Aged; Aspirin; Clopidogrel; Coronary Vessels; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Humans; International Cooperation; Male; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2000 |
Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: enhanced inhibitory effects of combination therapy.
Topics: Adenosine Diphosphate; Adult; Aged; Antigens, CD; Aspirin; Blood; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dual Specificity Phosphatase 2; Humans; Middle Aged; Myocardial Infarction; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prospective Studies; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Tetraspanin 30; Ticlopidine | 2000 |
Acute antithrombotic effect of a front-loaded regimen of clopidogrel in patients with atherosclerosis on aspirin.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Therapy, Combination; Fibrinogen; Fibrinolytic Agents; Humans; Perfusion; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2000 |
The Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) trial programme; rationale, design and baseline characteristics including a meta-analysis of the effects of thienopyridines in vascular disease.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Vascular Diseases | 2000 |
Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement.
Topics: Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Humans; Platelet Activation; Platelet Aggregation; Stents; Ticlopidine | 2001 |
Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery.
Topics: Aspirin; Cardiac Surgical Procedures; Clopidogrel; Double-Blind Method; Female; Hospitalization; Humans; Ischemia; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Ticlopidine | 2001 |
Comparison of effects of clopidogrel versus ticlopidine on platelet function in patients undergoing coronary stent placement.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Recurrence; Stents; Ticlopidine | 2001 |
Rationale, design and organization of the Second Chinese Cardiac Study (CCS-2): a randomized trial of clopidogrel plus aspirin, and of metoprolol, among patients with suspected acute myocardial infarction. Second Chinese Cardiac Study (CCS-2) Collaborativ
Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; China; Clopidogrel; Drug Therapy, Combination; Humans; Metoprolol; Myocardial Infarction; Platelet Aggregation Inhibitors; Research Design; Ticlopidine | 2000 |
Prolonged antiplatelet therapy to prevent late thrombosis after intracoronary gamma-radiation in patients with in-stent restenosis: Washington Radiation for In-Stent Restenosis Trial plus 6 months of clopidogrel (WRIST PLUS).
Topics: Aged; Clopidogrel; Coronary Angiography; Coronary Disease; Female; Follow-Up Studies; Gamma Rays; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2001 |
Randomized comparison of ticlopidine and clopidogrel after intracoronary stent implantation in a broad patient population.
Topics: Abciximab; Antibodies, Monoclonal; Clopidogrel; Coronary Disease; Coronary Thrombosis; Eptifibatide; Exanthema; Female; Gastrointestinal Diseases; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Neutropenia; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thrombocytopenia; Ticlopidine; Tirofiban; Tyrosine | 2001 |
Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation.
Topics: Acute Disease; Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2001 |
Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Female; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Preoperative Care; Proportional Hazards Models; Prospective Studies; Risk; Survival Analysis; Ticlopidine; Treatment Outcome | 2001 |
Recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Binding, Competitive; Blood Platelets; Clopidogrel; Flow Cytometry; Humans; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2001 |
Clopidogrel: hemorheological effects in subjects with subclinical atherosclerosis.
Topics: Adult; Arteriosclerosis; Blood Cell Count; Blood Viscosity; Clopidogrel; Double-Blind Method; Erythrocyte Indices; Female; Fibrinogen; Hemorheology; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Insights from CURE: using clopidogrel on top of standard therapy.
Topics: Aged; Angina, Unstable; Aspirin; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Heparin; Humans; Intracranial Arteriosclerosis; Intracranial Thrombosis; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Survival Analysis; Ticlopidine; Treatment Outcome | 2002 |
Cessation of embolic signals after antithrombotic prevention is related to reduced risk of recurrent arterioembolic transient ischaemic attack and stroke.
Topics: Aged; Aspirin; Clopidogrel; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Intracranial Embolism; Ischemic Attack, Transient; Male; Middle Aged; Recurrence; Risk; Ticlopidine; Ultrasonography, Doppler, Color; Ultrasonography, Doppler, Transcranial | 2002 |
Clopidogrel: a CURE in acute coronary syndromes?
Topics: Acute Disease; Aged; Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2002 |
Effects of combined therapy with clopidogrel and acetylsalicylic acid on platelet glycoprotein expression and aggregation.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Coronary Disease; Drug Synergism; Drug Therapy, Combination; Dual Specificity Phosphatase 2; Female; Humans; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Ticlopidine | 2002 |
Clopidogrel, but not abciximab, reduces platelet leukocyte conjugates and P-selectin expression in a human ex vivo in vitro model.
Topics: Abciximab; Adult; Analysis of Variance; Antibodies, Monoclonal; Cell Adhesion Molecules; Clopidogrel; Humans; Immunoglobulin Fab Fragments; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2002 |
Clopidogrel and the CURE results.
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Clopidogrel therapy in patients undergoing coronary stenting: value of a high-loading-dose regimen.
Topics: Abciximab; Aged; Antibodies, Monoclonal; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Preoperative Care; Stents; Ticlopidine | 2002 |
Clopidogrel inhibits platelet adhesion and platelet-dependent mitogenesis in vascular smooth muscle cells.
Topics: Adenosine Diphosphate; Adult; Animals; Blood Platelets; Cattle; Cell Culture Techniques; Cell Division; Clopidogrel; Culture Media, Conditioned; DNA Replication; Fibrinogen; Humans; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Paracrine Communication; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2002 |
Clopidogrel treatment before percutaneous coronary intervention reduces adverse cardiac events.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Humans; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Ticlopidine; Treatment Outcome | 2002 |
Use of clopidogrel loading, enoxaparin, and double-bolus eptifibatide in the setting of early percutaneous coronary intervention for acute coronary syndromes.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Enoxaparin; Eptifibatide; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Peptides; Pilot Projects; Platelet Aggregation Inhibitors; Preoperative Care; Ticlopidine; Treatment Outcome | 2002 |
Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin after coronary stent implantation: 1 and 6-month follow-up.
Topics: Aged; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Stenosis; Drug Therapy, Combination; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors | 2001 |
Comparison of antiplatelet effect of loading dose of clopidogrel versus abciximab during coronary intervention.
Topics: Abciximab; Adenosine Diphosphate; Aged; Aged, 80 and over; Angina Pectoris; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine; Treatment Outcome | 2002 |
The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Research Design; Ticlopidine; Treatment Outcome | 2002 |
A prospective randomized trial of aspirin-clopidogrel combination therapy and dose-adjusted warfarin on indices of thrombogenesis and platelet activation in atrial fibrillation.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Chronic Disease; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Female; Fibrin Fibrinogen Degradation Products; Follow-Up Studies; Humans; International Normalized Ratio; Male; Middle Aged; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Prothrombin; Ticlopidine; Treatment Outcome; Warfarin | 2002 |
Twelve versus six months of clopidogrel to reduce major cardiac events in patients undergoing gamma-radiation therapy for in-stent restenosis: Washington Radiation for In-Stent restenosis Trial (WRIST) 12 versus WRIST PLUS.
Topics: Aspirin; Brachytherapy; Clopidogrel; Coronary Restenosis; Drug Administration Schedule; Female; Gamma Rays; Graft Occlusion, Vascular; Heart Diseases; Humans; Iridium Radioisotopes; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk; Stents; Ticlopidine; Time; Treatment Outcome | 2002 |
Effect of additional temporary glycoprotein IIb/IIIa receptor inhibition on troponin release in elective percutaneous coronary interventions after pretreatment with aspirin and clopidogrel (TOPSTAR trial).
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Elective Surgical Procedures; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Stents; Ticlopidine; Tirofiban; Troponin T; Tyrosine | 2002 |
Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus.
Topics: Aged; Aspirin; Clopidogrel; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Endpoint Determination; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Patient Readmission; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk Factors; Ticlopidine; Treatment Outcome | 2002 |
Individual variations of platelet inhibition after loading doses of clopidogrel.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Follow-Up Studies; Genetic Variation; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2002 |
Benefit of clopidogrel in patients with acute coronary syndromes without ST-segment elevation in various risk groups.
Topics: Acute Disease; Aged; Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2002 |
Activated clotting times in the setting of eptifibatide use during percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Coagulation; Blood Coagulation Tests; Clopidogrel; Drug Therapy, Combination; Eptifibatide; Female; Heparin; Humans; Male; Middle Aged; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombophilia; Ticlopidine | 2002 |
Effectiveness of clopidogrel versus aspirin in preventing acute myocardial infarction in patients with symptomatic atherothrombosis (CAPRIE trial).
Topics: Age Factors; Aged; Aspirin; Clopidogrel; Creatinine; Diabetes Mellitus; Female; Humans; Male; Massachusetts; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2002 |
Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes.
Topics: Antigens; Aspirin; Biomarkers; Blood Coagulation; Blood Coagulation Factors; Clopidogrel; Cohort Studies; Coronary Disease; Drug Therapy, Combination; Female; Fibrin Fibrinogen Degradation Products; Humans; Male; Middle Aged; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; von Willebrand Factor | 2002 |
Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2002 |
A human model of platelet-leucocyte adhesive interactions during controlled ischaemia in patients with peripheral vascular disease.
Topics: Adult; Arterial Occlusive Diseases; Blood Platelets; Blood Viscosity; Cell Adhesion; Clopidogrel; Double-Blind Method; Exercise Test; Humans; Leukocytes; Male; Microcirculation; Middle Aged; Oxygen; Partial Pressure; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2002 |
Sustained platelet activation following intracoronary beta irradiation.
Topics: Angioplasty, Balloon, Coronary; Beta Particles; Blood Platelets; Brachytherapy; CD40 Ligand; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Prospective Studies; Stents; Strontium Radioisotopes; Ticlopidine; Yttrium Radioisotopes | 2002 |
Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Ticlopidine | 2002 |
[Effect of therapy with clopidogrel on walking tolerance and parameters of hemostasis in patients with atherosclerosis of lower extremities and intermittent claudication].
Topics: Aged; Arteriosclerosis; Clopidogrel; Female; Hemostasis; Humans; Lower Extremity; Male; Middle Aged; Movement Disorders; Physical Endurance; Platelet Aggregation Inhibitors; Ticlopidine; Walking | 2002 |
Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction.
Topics: Adolescent; Adult; Atorvastatin; Breath Tests; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Ticlopidine | 2003 |
Comparison of clopidogrel versus ticlopidine for prevention of minor myocardial injury after elective coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Coronary Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Reperfusion Injury; Primary Prevention; Probability; Prospective Studies; Risk Assessment; Stents; Ticlopidine; Treatment Outcome | 2003 |
Oral antiplatelet therapies have no effect on circulating levels of RANTES in patients with coronary artery disease.
Topics: Aged; Angina, Unstable; Chemokine CCL5; Chemokines; Clopidogrel; Coronary Artery Disease; Female; Heart Failure; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2002 |
Early and late effects of clopidogrel in patients with acute coronary syndromes.
Topics: Acute Disease; Angina, Unstable; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Kinetics; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Risk Assessment; Secondary Prevention; Stroke; Syndrome; Ticlopidine; Treatment Outcome | 2003 |
Platelet function under aspirin, clopidogrel, and both after ischemic stroke: a case-crossover study.
Topics: Antigens, CD; Aspirin; Blood Platelets; Brain Ischemia; Case-Control Studies; Clopidogrel; Cross-Over Studies; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Secondary Prevention; Stroke; Tetraspanin 30; Ticlopidine | 2003 |
A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after the placement of coronary artery stents.
Topics: Aged; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Survival Rate; Ticlopidine; Time Factors | 2003 |
Coronary stenting in stable patients: identification of a low-risk subgroup that may not require adjunctive antiplatelet therapy.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Chemotherapy, Adjuvant; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Coronary Disease; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Male; Probability; Prospective Studies; Reference Values; Risk Assessment; Severity of Illness Index; Stents; Survival Analysis; Ticlopidine; Treatment Outcome | 2003 |
The Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study: to what extent should the results be generalizable?
Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Female; Heart Failure; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Stents; Stroke; Thrombosis; Ticlopidine | 2003 |
A paclitaxel-eluting stent for the prevention of coronary restenosis.
Topics: Angiogenesis Inhibitors; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Restenosis; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hyperplasia; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Tunica Intima; Ultrasonography, Interventional | 2003 |
Clopidogrel and aspirin in the prevention of thromboembolic complications after mechanical aortic valve replacement (CAPTA).
Topics: Administration, Oral; Adult; Aged; Aortic Valve; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Heart Valve Prosthesis; Hemorrhage; Humans; Male; Middle Aged; Phenprocoumon; Pilot Projects; Thromboembolism; Ticlopidine; Treatment Outcome | 2003 |
Durability of platelet inhibition by clopidogrel.
Topics: Aged; Aspirin; Clopidogrel; Coronary Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors | 2003 |
Changes in platelet P-selectin and in plasma C-reactive protein in acute atherosclerotic ischemic stroke treated with a loading dose of clopidogrel.
Topics: Aged; Arteriosclerosis; Aspirin; Blood Platelets; Brain Ischemia; C-Reactive Protein; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2002 |
Clopidogrel and warfarin: absence of interaction in patients receiving long-term anticoagulant therapy for non-valvular atrial fibrillation.
Topics: Aged; Anticoagulants; Atrial Fibrillation; Clopidogrel; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; International Normalized Ratio; Male; Middle Aged; Stereoisomerism; Ticlopidine; Time Factors; Warfarin | 2003 |
Cerebral microembolism is blocked by tirofiban, a selective nonpeptide platelet glycoprotein IIb/IIIa receptor antagonist.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Carotid Artery Diseases; Clopidogrel; Female; Humans; Infusions, Intravenous; Intracranial Embolism; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine; Ultrasonography, Doppler, Transcranial | 2003 |
Effects of coadministration of aspirin or clopidogrel on exercise testing in patients with heart failure receiving angiotensin-converting enzyme inhibitors.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Cross-Over Studies; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Exercise Test; Heart Failure; Humans; Middle Aged; Oxygen Consumption; Physical Endurance; Platelet Aggregation Inhibitors; Ticlopidine; Time | 2003 |
Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity.
Topics: Adenosine Diphosphate; Aged; Aspirin; Biomarkers; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Genetic Variation; Humans; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2003 |
The effect of a loading dose (300 mg) of clopidogrel on platelet function in patients with peripheral arterial disease.
Topics: Aged; Aspirin; Blood Platelets; Cell Size; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Serotonin; Ticlopidine | 2003 |
The early antiplatelet effects of clopidogrel loading for coronary stenting and the long-term stability of inhibition.
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors | 2003 |
[Non ST elevation acute coronary syndrome. Parameters of fibrinolysis during short term use of ticlopidine or clopidogrel].
Topics: Acute Disease; Adult; Antithrombins; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Fibrinolysis; Humans; Male; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine; Time Factors | 2003 |
[Clopidogrel as adjunctive medication in patients with acute coronary syndrome].
Topics: Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Placebo Effect; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2002 |
Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial.
Topics: Angioplasty, Balloon, Coronary; Atorvastatin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Female; Hemorrhage; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyrroles; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Stroke; Ticlopidine; Treatment Outcome | 2003 |
Randomized controlled trial of clopidogrel plus aspirin to prevent hemodialysis access graft thrombosis.
Topics: Aged; Aspirin; Catheters, Indwelling; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Platelet Aggregation Inhibitors; Polytetrafluoroethylene; Renal Dialysis; Thrombosis; Ticlopidine | 2003 |
A comparison of 1-month and 6-month clopidogrel therapy on clinical and angiographic outcome after stent implantation.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Restenosis; Drug Administration Schedule; Female; Follow-Up Studies; Heparin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2003 |
Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study.
Topics: Acute Disease; Angina, Unstable; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Incidence; Male; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Stroke; Syndrome; Ticlopidine; Treatment Outcome | 2003 |
Evaluation of prolonged antithrombotic pretreatment ("cooling-off" strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial.
Topics: Aged; Angina Pectoris; Aspirin; Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Heparin; Humans; Male; Middle Aged; Myocardial Revascularization; Platelet Aggregation Inhibitors; Preoperative Care; Risk; Stents; Ticlopidine; Tirofiban; Treatment Outcome; Troponin T; Tyrosine | 2003 |
Prediction of significant left main coronary artery stenosis by the 12-lead electrocardiogram in patients with rest angina pectoris and the withholding of clopidogrel therapy.
Topics: Adult; Aged; Angina, Unstable; Clopidogrel; Coronary Angiography; Coronary Stenosis; Electrocardiography; Female; Humans; Male; Middle Aged; Outcome and Process Assessment, Health Care; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Ticlopidine; Withholding Treatment | 2003 |
Triple antiplatelet therapy during percutaneous coronary intervention is associated with improved outcomes including one-year survival: results from the Do Tirofiban and ReoProGive Similar Efficacy Outcome Trial (TARGET).
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Combined Modality Therapy; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Louisiana; Male; Middle Aged; Minnesota; Myocardial Infarction; New York City; Ohio; Pennsylvania; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Care; Premedication; Severity of Illness Index; Stents; Survival Analysis; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2003 |
Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function--a flow cytometry study.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Flow Cytometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; P-Selectin; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Time Factors | 2003 |
Managing PAD with multiple platelet inhibitors: the effect of combination therapy on bleeding time.
Topics: Aged; Arterial Occlusive Diseases; Aspirin; Bleeding Time; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Humans; Intermittent Claudication; Leg; Male; Platelet Aggregation Inhibitors; Prospective Studies; Tetrazoles; Ticlopidine | 2003 |
Effects of clopidogrel and aspirin combination versus aspirin alone on platelet aggregation and major receptor expression in patients with heart failure: the Plavix Use for Treatment Of Congestive Heart Failure (PLUTO-CHF) trial.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Heart Failure; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Statistics as Topic; Ticlopidine | 2003 |
Effects of statins on platelet inhibition by a high loading dose of clopidogrel.
Topics: Aged; Angina Pectoris; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2003 |
[Non ST elevation acute coronary syndrome. Some characteristics of coagulation and von Willebrand factor during short term use of ticlopidine or clopidogrel].
Topics: Acute Disease; Adult; Angina, Unstable; Anticoagulants; Aspirin; Blood Coagulation; Clopidogrel; Data Interpretation, Statistical; Electrocardiography; Female; Fibrinolytic Agents; Heparin; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine; Time Factors; Treatment Outcome; von Willebrand Factor | 2003 |
Effects of 2 different antiplatelet regimens with abciximab or tirofiban on platelet function in patients undergoing coronary stenting.
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Stents; Ticlopidine; Tirofiban; Tyrosine | 2003 |
Triple antiplatelet therapy does not increase femoral access bleeding with vascular closure devices.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Femoral Artery; Hemorrhage; Hemostasis, Surgical; Heparin; Humans; Male; Middle Aged; Patient Selection; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Suture Techniques; Ticlopidine | 2004 |
The effect of preoperative antiplatelet/anticoagulant prophylaxis on postoperative blood loss in cardiac surgery.
Topics: Adenosine Diphosphate; Aged; Anticoagulants; Body Temperature; Cardiac Surgical Procedures; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Female; Fibrinogen; Hemostasis; Heparin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Premedication; Prospective Studies; Purinergic P2 Receptor Antagonists; Ticlopidine | 2004 |
Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance.
Topics: Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Resistance; Humans; Liver; Platelet Aggregation Inhibitors; Rifampin; Ticlopidine | 2004 |
A clinical trial of abciximab in elective percutaneous coronary intervention after pretreatment with clopidogrel.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Coronary Disease; Coronary Restenosis; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Preoperative Care; Ticlopidine | 2004 |
Clopidogrel: potential in the prevention of cardiovascular events in patients with acute coronary syndromes.
Topics: Angioplasty, Balloon; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine | 2001 |
Eptifibatide provides additional platelet inhibition in non-ST-elevation myocardial infarction patients already treated with aspirin and clopidogrel. Results of the platelet activity extinction in non-Q-wave myocardial infarction with aspirin, clopidogrel
Topics: Aged; Aspirin; Clopidogrel; Drug Synergism; Drug Therapy, Combination; Enoxaparin; Eptifibatide; Female; Fibrinogen; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Peptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Treatment Outcome | 2004 |
Combination antiplatelet therapy in patients with peripheral vascular bypass grafts.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions.
Topics: Aged; Anticoagulants; Aspirin; Catheterization; Clopidogrel; Combined Modality Therapy; Comorbidity; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Coronary Thrombosis; Coronary Vessels; Death, Sudden; Diabetes Mellitus; Disease-Free Survival; Drug Implants; Female; Follow-Up Studies; Humans; Life Tables; Male; Middle Aged; Pilot Projects; Postoperative Complications; Prospective Studies; Safety; Sirolimus; Stents; Survival Analysis; Ticlopidine; Treatment Outcome | 2004 |
Management of atherothrombosis with clopidogrel in high-risk patients with recent transient ischaemic attack or ischaemic stroke (MATCH): study design and baseline data.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Thrombosis; Ticlopidine | 2004 |
Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Omeprazole; Peptic Ulcer; Peptic Ulcer Hemorrhage; Risk Factors; Single-Blind Method; Ticlopidine | 2004 |
Beneficial effects of clopidogrel combined with aspirin in reducing cerebral emboli in patients undergoing carotid endarterectomy.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Disease Progression; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Humans; Intracranial Embolism; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Period; Premedication; Risk; Ticlopidine; Treatment Outcome; Ultrasonography, Doppler, Transcranial; Wound Healing | 2004 |
Effects of pretreatment with clopidogrel on platelet and coagulation activation in patients undergoing elective coronary stenting.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; beta-Thromboglobulin; Blood Vessel Prosthesis; Clopidogrel; Coronary Thrombosis; Double-Blind Method; Humans; Male; Middle Aged; Platelet Activation; Stents; Ticlopidine | 2003 |
Leukocyte count as an independent predictor of recurrent ischemic events.
Topics: Aspirin; Biomarkers; Brain Ischemia; Cause of Death; Clopidogrel; Female; Humans; Inflammation; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Peripheral Vascular Diseases; Predictive Value of Tests; Prognosis; Prospective Studies; Recurrence; Risk Factors; Stroke; Ticlopidine | 2004 |
Clopidogrel does not increase bleeding and allogenic blood transfusion in coronary artery surgery.
Topics: Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Female; Humans; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Prospective Studies; Risk Factors; Ticlopidine | 2004 |
Effect of clopidogrel pretreatment on inflammatory marker expression in patients undergoing percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; CD40 Ligand; Clopidogrel; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Interleukin-6; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Ticlopidine | 2004 |
Atorvastatin does not affect the antiplatelet potency of clopidogrel when it is administered concomitantly for 5 weeks in patients with acute coronary syndromes.
Topics: Acute Disease; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Atorvastatin; CD40 Ligand; Clopidogrel; Combined Modality Therapy; Coronary Disease; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inactivation, Metabolic; Male; Middle Aged; P-Selectin; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Stents; Ticlopidine; Treatment Outcome | 2004 |
A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after coronary stent implantation.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Stenosis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2004 |
Cost-effectiveness of clopidogrel in acute coronary syndromes in Sweden: a long-term model based on the CURE trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Clopidogrel; Coronary Disease; Cost of Illness; Cost-Benefit Analysis; Drug Costs; Epidemiologic Methods; Female; Health Care Costs; Humans; Male; Markov Chains; Middle Aged; Models, Econometric; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Sweden; Ticlopidine | 2004 |
The Warfarin and Antiplatelet Therapy in Heart Failure trial (WATCH): rationale, design, and baseline patient characteristics.
Topics: Adult; Aged; Anticoagulants; Aspirin; Clopidogrel; Embolism; Female; Heart Failure; Humans; Male; Middle Aged; Patient Selection; Platelet Aggregation Inhibitors; Prospective Studies; Research Design; Ticlopidine; Warfarin | 2004 |
Watching the WATCH trial: the role of sponsors and data monitoring committees.
Topics: Anticoagulants; Aspirin; Clinical Trials Data Monitoring Committees; Clopidogrel; Heart Failure; Humans; Platelet Aggregation Inhibitors; Research Design; Research Support as Topic; Ticlopidine; Warfarin | 2004 |
Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: implications for thrombotic events and restenosis.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Clopidogrel; Coronary Restenosis; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Failure | 2004 |
The effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial disease.
Topics: Adenosine Diphosphate; Aged; Arteriosclerosis; Aspirin; Blood Platelets; Cell Shape; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; P-Selectin; Peripheral Vascular Diseases; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; Serotonin; Ticlopidine | 2004 |
Is a 300 mg clopidogrel loading dose sufficient to inhibit platelet function early after coronary stenting? A platelet function profile study.
Topics: Adenosine Diphosphate; Clopidogrel; Coronary Vessels; Female; Fibrinogen; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Stents; Thrombosis; Ticlopidine; von Willebrand Factor | 2004 |
Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; CD40 Ligand; Clopidogrel; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Leukocytes; Male; Middle Aged; Myocardial Infarction; P-Selectin; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2004 |
Comparison between ticlopidine and clopidogrel in patients with ST-segment elevation myocardial infarction treated with coronary stenting.
Topics: Aged; Clopidogrel; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Perioperative Care; Platelet Aggregation Inhibitors; Prosthesis Implantation; Risk Factors; Stents; Survival Analysis; Ticlopidine; Treatment Outcome | 2004 |
Short-term prevention of thromboembolic complications in patients with atrial fibrillation with aspirin plus clopidogrel: the Clopidogrel-Aspirin Atrial Fibrillation (CLAAF) pilot study.
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Bleeding Time; Clopidogrel; Drug Therapy, Combination; Echocardiography, Transesophageal; Electric Countershock; Female; Humans; International Normalized Ratio; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Thromboembolism; Thromboxane B2; Ticlopidine; Warfarin | 2004 |
Lack of efficacy of clopidogrel pre-treatment in the prevention of myocardial damage after elective stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Angiography; Coronary Disease; Creatine Kinase; Creatine Kinase, MB Form; Female; Follow-Up Studies; Humans; Isoenzymes; Male; Middle Aged; Myocardial Infarction; Netherlands; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine; Treatment Outcome; Troponin I | 2004 |
Anti-Xa activity relates to survival and efficacy in unselected acute coronary syndrome patients treated with enoxaparin.
Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Cardiac Catheterization; Clopidogrel; Cohort Studies; Combined Modality Therapy; Creatine Kinase; Creatine Kinase, MB Form; Drug Therapy, Combination; Enoxaparin; Factor Xa Inhibitors; Female; Follow-Up Studies; Hemorrhage; Humans; Isoenzymes; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Survival Analysis; Ticlopidine; Treatment Outcome; Troponin I | 2004 |
Treatment of left anterior descending coronary artery disease with sirolimus-eluting stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Double-Blind Method; Drug Implants; Female; Humans; Life Tables; Male; Middle Aged; Myocardial Infarction; Premedication; Sirolimus; Stents; Survival Analysis; Ticlopidine; Treatment Outcome; Ultrasonography | 2004 |
Measurement of platelet aggregation during antiplatelet therapy in ischemic stroke.
Topics: Adenosine Diphosphate; Adult; Aspirin; Brain Ischemia; Clopidogrel; Cohort Studies; Collagen; Epinephrine; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Ticlopidine | 2004 |
A randomized crossover comparative study of aspirin, cilostazol and clopidogrel in normal controls: analysis with quantitative bleeding time and platelet aggregation test.
Topics: Adult; Aspirin; Bleeding Time; Cilostazol; Clopidogrel; Cross-Over Studies; Double-Blind Method; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Tetrazoles; Ticlopidine; Time Factors | 2004 |
Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy.
Topics: Aged; Aspirin; Blood Platelets; C-Reactive Protein; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Ticlopidine | 2004 |
Cost-effectiveness of sirolimus-eluting stents for treatment of complex coronary stenoses: results from the Sirolimus-Eluting Balloon Expandable Stent in the Treatment of Patients With De Novo Native Coronary Artery Lesions (SIRIUS) trial.
Topics: Angioplasty, Balloon, Coronary; Cardiac Catheterization; Clopidogrel; Coronary Restenosis; Cost-Benefit Analysis; Diabetes Mellitus; Double-Blind Method; Drug Costs; Equipment Design; Female; Follow-Up Studies; Health Care Costs; Health Resources; Hospital Costs; Humans; Male; Middle Aged; Myocardial Revascularization; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Sirolimus; Stents; Ticlopidine; Treatment Outcome; United States | 2004 |
Clopidogrel does not induce fibrinolysis in healthy subjects.
Topics: Administration, Oral; Adult; Circadian Rhythm; Clopidogrel; Female; Fibrinolysis; Fibrinolytic Agents; Humans; Male; Platelet Aggregation Inhibitors; Reference Values; Ticlopidine | 2004 |
Clopidogrel added to aspirin versus aspirin alone in secondary prevention and high-risk primary prevention: rationale and design of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial.
Topics: Arteriosclerosis; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Middle Aged; Platelet Aggregation Inhibitors; Primary Prevention; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Thrombosis; Ticlopidine | 2004 |
Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) Trial.
Topics: Acute Disease; Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Risk; Stroke; Ticlopidine; Treatment Outcome | 2004 |
Preventive administration of Clopidogrel after restoring patency of acute dialysis fistula with surgical thrombectomy.
Topics: Adult; Aged; Arteriovenous Shunt, Surgical; Clopidogrel; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombectomy; Thrombosis; Ticlopidine; Treatment Outcome | 2003 |
[First experience of clopidogrel application in the treatment of acute myocardial infarction with ST-elevation].
Topics: Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Streptokinase; Ticlopidine; Time Factors; Tissue Plasminogen Activator; Treatment Outcome | 2004 |
The effect of long-term clopidogrel use on neointimal formation after percutaneous coronary intervention.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prosthesis Implantation; Stents; Ticlopidine; Time Factors; Tunica Intima; Ultrasonography, Interventional | 2004 |
ADP induced platelet degranulation in healthy individuals is reduced by clopidogrel after pretreatment with atorvastatin.
Topics: Adenosine Diphosphate; Adolescent; Adult; Atorvastatin; Cell Degranulation; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Fibrinogen; Heptanoic Acids; Humans; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Pyrroles; Ticlopidine | 2004 |
Clopidogrel and bleeding in patients undergoing elective coronary artery bypass grafting.
Topics: Algorithms; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Risk Factors; Ticlopidine | 2004 |
Clopidogrel did not inhibit platelet function early after coronary bypass surgery: A prospective randomized trial.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2004 |
Direct stenting versus direct stenting followed by centered beta-radiation with intravascular ultrasound-guided dosimetry and long-term anti-platelet treatment: results of a randomized trial: Beta-Radiation Investigation with Direct Stenting and Galileo i
Topics: Aged; Aspirin; Brachytherapy; Clopidogrel; Coronary Angiography; Coronary Restenosis; Europe; Female; Humans; Hyperplasia; Male; Middle Aged; Phosphorus Radioisotopes; Platelet Aggregation Inhibitors; Primary Prevention; Radiation Dosage; Stents; Ticlopidine; Tunica Intima; Ultrasonography, Interventional | 2004 |
Achieved platelet aggregation inhibition after different antiplatelet regimens during percutaneous coronary intervention for ST-segment elevation myocardial infarction.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Complications; Survival Analysis; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2004 |
Lack of clopidogrel pretreatment effect on the relative efficacy of bivalirudin with provisional glycoprotein IIb/IIIa blockade compared to heparin with routine glycoprotein IIb/IIIa blockade: a REPLACE-2 substudy.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Clopidogrel; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Endpoint Determination; Female; Fibrinolytic Agents; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Survival Analysis; Ticlopidine; Treatment Outcome | 2004 |
Magnetic Vascular Port in minimally invasive direct coronary artery bypass grafting.
Topics: Aged; Aspirin; Clopidogrel; Comorbidity; Coronary Angiography; Drug Therapy, Combination; Equipment Design; Female; Follow-Up Studies; Humans; Internal Mammary-Coronary Artery Anastomosis; Magnetics; Male; Middle Aged; Minimally Invasive Surgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Surgical Instruments; Thrombosis; Ticlopidine; Treatment Outcome; Vascular Patency | 2004 |
Prothrombotic responses to exercise are little influenced by clopidogrel treatment.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Adhesion; Clopidogrel; Cross-Over Studies; Exercise; Humans; Leukocytes; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombophilia; Thromboxane B2; Ticlopidine | 2004 |
[Dysaggregants effect of platelet aggregation in patients with non-ST segment elevation acute coronary syndrome].
Topics: Acute Disease; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Electrocardiography; Female; Humans; Male; Nadroparin; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2004 |
Bioequivalence study of clopidogrel bisulfate film-coated tablets.
Topics: Adolescent; Adult; Area Under Curve; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Clopidogrel; Cross-Over Studies; Female; Half-Life; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Tablets; Therapeutic Equivalency; Ticlopidine | 2004 |
Randomized clinical trial of abciximab in diabetic patients undergoing elective percutaneous coronary interventions after treatment with a high loading dose of clopidogrel.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Diabetes Complications; Elective Surgical Procedures; Endpoint Determination; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk; Stents; Ticlopidine | 2004 |
A randomized comparison of the effects of aspirin and clopidogrel on thrombotic risk factors and C-reactive protein following myocardial infarction: the CADET trial.
Topics: Aged; Aspirin; Biomarkers; Blood Coagulation Factors; Blood Viscosity; C-Reactive Protein; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2004 |
[The results of the MATCH study evidence for advantages of Clopidogrel monotherapy as secondary prophylaxis in cerebrovascular pathology].
Topics: Aged; Brain Ischemia; Clopidogrel; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Safety; Ticlopidine; Treatment Outcome | 2004 |
The difference between clopidogrel responsiveness and posttreatment platelet reactivity.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Predictive Value of Tests; Prognosis; Risk; Stents; Thrombosis; Ticlopidine | 2005 |
The cost-effectiveness of the use of clopidogrel in acute coronary syndromes in five countries based upon the CURE study.
Topics: Angina, Unstable; Canada; Clopidogrel; Cost-Benefit Analysis; Europe; Health Care Costs; Hospitalization; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; United States | 2004 |
Influence of treatment duration with a 600-mg dose of clopidogrel before percutaneous coronary revascularization.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Stents; Ticlopidine; Treatment Outcome | 2004 |
Variable extent of clopidogrel responsiveness in patients after coronary stenting.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; GTP-Binding Protein alpha Subunits, Gi-Go; Heart Diseases; Humans; Male; Membrane Proteins; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Ticlopidine; Treatment Outcome | 2004 |
Quantitative assessment of angiographic restenosis after sirolimus-eluting stent implantation in native coronary arteries.
Topics: Aged; Aspirin; Clopidogrel; Coronary Aneurysm; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Diabetes Complications; Double-Blind Method; Drug Implants; Drug Therapy, Combination; Female; Follow-Up Studies; Heparin; Humans; Incidence; Male; Middle Aged; Randomized Controlled Trials as Topic; Sirolimus; Stents; Ticlopidine; Treatment Outcome | 2004 |
Lack of clopidogrel-CYP3A4 statin interaction in patients with acute coronary syndrome.
Topics: Aged; Angina, Unstable; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prospective Studies; Survival Analysis; Ticlopidine; Treatment Outcome | 2005 |
Randomized clinical trial of the antiplatelet effects of aspirin-clopidogrel combination versus aspirin alone after lower limb angioplasty.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Endarterectomy; Female; Fibrinogen; Flow Cytometry; Humans; Intermittent Claudication; Leg; Male; Middle Aged; P-Selectin; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2005 |
Time lag in platelet function inhibition by clopidogrel in stroke patients as measured by PFA-100.
Topics: Clopidogrel; Hematologic Tests; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Stroke; Ticlopidine; Time Factors | 2004 |
Does pre-treatment with aspirin and loading dose clopidogrel obviate the need for glycoprotein IIb/IIIa antagonists during elective coronary stenting? A focus on peri-procedural myonecrosis.
Topics: Abciximab; Aged; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Creatine Kinase; Creatine Kinase, MB Form; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Isoenzymes; Logistic Models; Male; Middle Aged; Neovascularization, Pathologic; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Recurrence; Stents; Survival Rate; Thrombosis; Ticlopidine; Troponin T | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Esomeprazole; Female; Humans; Male; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Secondary Prevention; Ticlopidine | 2005 |
GPIIb-IIIa antagonists reduce thromboinflammatory processes in patients with acute coronary syndromes undergoing percutaneous coronary intervention.
Topics: Abciximab; Acute Disease; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Blood Platelets; CD40 Ligand; Clopidogrel; Coronary Disease; Female; Humans; Immunoglobulin Fab Fragments; Inflammation; Leukocytes; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2005 |
Enhanced antiplatelet effects of clopidogrel plus acetylsalicylic acid compared with acetylsalicylic acid alone or combined with extended-release dipyridamole in healthy volunteers.
Topics: Adult; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Collagen; Cross-Over Studies; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
One year outcomes with abciximab vs. placebo during percutaneous coronary intervention after pre-treatment with clopidogrel.
Topics: Abciximab; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Death, Sudden, Cardiac; Disease-Free Survival; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2005 |
Effects of aspirin, clopidogrel and dipyridamole administered singly and in combination on platelet and leucocyte function in normal volunteers and patients with prior ischaemic stroke.
Topics: Adult; Aged; Aspirin; Blood Platelets; Brain Ischemia; Case-Control Studies; Cell Adhesion; Clopidogrel; Cross-Over Studies; Dipyridamole; Drug Therapy, Combination; Female; Humans; Leukocytes; Male; Middle Aged; Platelet Aggregation; Stroke; Ticlopidine | 2005 |
Closure devices and vascular complications among percutaneous coronary intervention patients receiving enoxaparin, glycoprotein IIb/IIIa inhibitors, and clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Angiography; Enoxaparin; Equipment Design; Female; Femoral Artery; Follow-Up Studies; Hemostasis, Surgical; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Hemorrhage; Punctures; Ticlopidine; Treatment Outcome | 2005 |
Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiovascular Agents; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Eptifibatide; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Risk Factors; Stents; Ticlopidine | 2005 |
Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty)
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; Clopidogrel; Creatine Kinase; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Myoglobin; Platelet Aggregation Inhibitors; Premedication; Ticlopidine; Troponin I | 2005 |
Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Drug Therapy, Combination; Electrocardiography; Female; Fibrinolytic Agents; Hemorrhage; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Secondary Prevention; Thrombolytic Therapy; Ticlopidine; Vascular Patency | 2005 |
Long-term cost-effectiveness of clopidogrel given for up to one year in patients with acute coronary syndromes without ST-segment elevation.
Topics: Acute Disease; Aged; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Electrocardiography; Female; Follow-Up Studies; Humans; Length of Stay; Life Expectancy; Male; Medicare; Middle Aged; Myocardial Infarction; Patient Admission; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Sensitivity and Specificity; Syndrome; Ticlopidine; Time; Treatment Outcome; United States | 2005 |
What is the risk of stent thrombosis associated with the use of paclitaxel-eluting stents for percutaneous coronary intervention?: a meta-analysis.
Topics: Aged; Angioplasty, Balloon, Coronary; Antineoplastic Agents, Phytogenic; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coated Materials, Biocompatible; Coronary Artery Disease; Coronary Thrombosis; Female; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2005 |
Comparison of cilostazol and clopidogrel after successful coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Restenosis; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
The effect of tirofiban and clopidogrel pretreatment on outcome of old saphenous vein graft stenting in patients with acute coronary syndromes.
Topics: Acute Disease; Clopidogrel; Coronary Disease; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Saphenous Vein; Stents; Ticlopidine; Tirofiban; Tyrosine | 2005 |
Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Cardiac Catheterization; Clopidogrel; Cohort Studies; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pharmacokinetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2005 |
Inter-individual variability in response to clopidogrel in patients with coronary artery disease.
Topics: Adult; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome | 2005 |
Monitoring of clopidogrel action: comparison of methods.
Topics: Adult; Aspirin; Biomarkers; Bleeding Time; Cell Adhesion Molecules; Clopidogrel; Drug Monitoring; Female; Flow Cytometry; Humans; Immunoenzyme Techniques; In Vitro Techniques; Male; Microfilament Proteins; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2005 |
Extracardiac vascular disease and effectiveness of sustained clopidogrel treatment.
Topics: Aged; Cerebrovascular Disorders; Clopidogrel; Epidemiologic Methods; Female; Humans; Male; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2006 |
Pharmacodynamics and pharmacokinetics of the platelet GPIIb/IIIa inhibitor tirofiban in patients undergoing percutaneous coronary intervention: implications for adjustment of tirofiban and clopidogrel dosage.
Topics: Age Factors; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pharmacokinetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Tirofiban; Tyrosine | 2005 |
Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.
Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Drug Monitoring; Drug Therapy, Combination; Embolism; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2005 |
The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Coronary Stenosis; Dose-Response Relationship, Drug; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine; Treatment Outcome | 2005 |
Carotid artery stents for blunt cerebrovascular injury: risks exceed benefits.
Topics: Adult; Aneurysm, False; Anticoagulants; Carotid Artery Injuries; Cerebral Angiography; Clopidogrel; Databases, Factual; Female; Fibrinolytic Agents; Heparin; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Risk Assessment; Stents; Ticlopidine; Wounds, Nonpenetrating | 2005 |
Inhibition of platelet aggregation with eptifibatide, bivalirudin, and heparin in patients undergoing percutaneous coronary intervention receiving clopidogrel pretreatment (The PharmacoDynamic Evaluation of Angiomax, Clopidogrel with or without INtegrilin
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Drug Therapy, Combination; Eptifibatide; Female; Follow-Up Studies; Heparin; Hirudins; Humans; Male; Middle Aged; Myocardial Ischemia; Peptide Fragments; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Preoperative Care; Recombinant Proteins; Ticlopidine; Treatment Outcome | 2005 |
Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Bupropion; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2B6; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Humans; Hydroxylation; Male; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
The benefits of combined anti-platelet treatment in carotid artery stenting.
Topics: Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine | 2005 |
Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial.
Topics: Adolescent; Adult; Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hemorrhage; Humans; Incidence; Male; Membrane Proteins; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2005 |
Comparison of two strategies for the management of antiplatelet therapy during urgent surgery.
Topics: Aged; Angina, Unstable; Aprotinin; Aspirin; Clopidogrel; Coronary Artery Bypass; Female; Hemostatics; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Comparison of modified Thrombelastograph and Plateletworks whole blood assays to optical platelet aggregation for monitoring reversal of clopidogrel inhibition in elective surgery patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clopidogrel; Elective Surgical Procedures; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Preoperative Care; Reproducibility of Results; Sensitivity and Specificity; Thrombelastography; Ticlopidine | 2005 |
Effect of clopidogrel plus aspirin on tissue perfusion and coronary flow in patients with ST-segment elevation myocardial infarction: a new reperfusion strategy.
Topics: Aged; Aspirin; Clopidogrel; Coronary Circulation; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Regional Blood Flow; Ticlopidine | 2005 |
Prospective randomized comparison of early and late results of a carbonized stent versus a high-grade stainless steel stent of identical design: the PREVENT Trial [corrected].
Topics: Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Biocompatible Materials; Carbon; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Coronary Disease; Coronary Restenosis; Equipment Design; Female; Heparin; Humans; Male; Materials Testing; Middle Aged; Prospective Studies; Recurrence; Stainless Steel; Stents; Thromboembolism; Thrombophilia; Ticlopidine; Time Factors; Treatment Outcome; Venous Thrombosis | 2005 |
Superior efficacy of clopidogrel plus acetylsalicylic acid compared with extended-release dipyridamole plus acetylsalicylic acid in preventing arterial thrombogenesis in healthy volunteers.
Topics: Adolescent; Adult; Arteries; Aspirin; Clopidogrel; Collagen; Cross-Over Studies; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Fibrin; Humans; Immunoenzyme Techniques; Male; Perfusion; Platelet Adhesiveness; Platelet Function Tests; Thrombosis; Ticlopidine | 2005 |
A randomized trial comparing clopidogrel versus ticlopidine therapy in patients undergoing infarct artery stenting for acute myocardial infarction with abciximab as adjunctive therapy.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Female; Fibrinolytic Agents; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Radionuclide Imaging; Recurrence; Stents; Survival Analysis; Ticlopidine; Treatment Failure | 2005 |
Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drug.
Topics: Aged; Angina Pectoris; Anticoagulants; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Time Factors; Treatment Outcome | 2005 |
Clopidogrel has no effect on D-dimer and thrombin-antithrombin III levels in patients with peripheral arterial disease undergoing peripheral percutaneous transluminal angioplasty.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Anti-Inflammatory Agents, Non-Steroidal; Antithrombin III; Aspirin; Clopidogrel; Double-Blind Method; Female; Fibrin Fibrinogen Degradation Products; Humans; Intermittent Claudication; Male; Middle Aged; Peptide Hydrolases; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Aprotinin reduces bleeding and blood product use in patients treated with clopidogrel before coronary artery bypass grafting.
Topics: Aged; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Blood Volume; Clopidogrel; Coronary Artery Bypass; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hemostatics; Humans; Intraoperative Care; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2005 |
Clopidogrel and bleeding after coronary artery bypass graft surgery.
Topics: Aged; Aspirin; Blood Transfusion; Blood Volume; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Outcome and Process Assessment, Health Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Prospective Studies; Ticlopidine | 2005 |
Long-term cost effectiveness of early and sustained dual oral antiplatelet therapy with clopidogrel given for up to one year after percutaneous coronary intervention results: from the Clopidogrel for the Reduction of Events During Observation (CREDO) tria
Topics: Aspirin; Cardiac Catheterization; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2005 |
Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 2005 |
Effects of clopidogrel and aspirin in combination versus aspirin alone on platelet activation and major receptor expression in patients after recent ischemic stroke: for the Plavix Use for Treatment of Stroke (PLUTO-Stroke) trial.
Topics: Aged; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Blood Platelets; Brain Ischemia; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Ticlopidine; Time Factors; Tomography, X-Ray Computed | 2005 |
Aprotinin decreases postoperative bleeding and number of transfusions in patients on clopidogrel undergoing coronary artery bypass graft surgery: a double-blind, placebo-controlled, randomized clinical trial.
Topics: Aged; Angina, Unstable; Anticoagulants; Aprotinin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Drug Administration Schedule; Erythrocyte Transfusion; Female; Hemostatics; Heparin; Humans; Intraoperative Care; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Postoperative Hemorrhage; Risk; Ticlopidine; Treatment Outcome | 2005 |
A global view of atherothrombosis: baseline characteristics in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Cardiovascular Diseases; Clopidogrel; Coronary Disease; Female; Humans; Ischemia; Leg; Male; Middle Aged; Myocardial Infarction; Risk Factors; Ticlopidine | 2005 |
Effects of tirofiban plus clopidogrel versus clopidogrel plus provisional abciximab on biomarkers of myocardial necrosis in patients with non-ST-elevation acute coronary syndromes treated with early aggressive approach. Results of the CLOpidogrel, upstrea
Topics: Abciximab; Acute Disease; Aged; Angina, Unstable; Antibodies, Monoclonal; Clopidogrel; Creatine Kinase, MB Form; Electrocardiography; Female; Humans; Immunoglobulin Fab Fragments; Male; Myocardial Infarction; Necrosis; Prospective Studies; Syndrome; Ticlopidine; Time Factors; Tirofiban; Troponin I; Tyrosine | 2005 |
Relation of aspirin resistance to coronary flow reserve in patients undergoing elective percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Circulation; Drug Resistance; Female; Humans; Linear Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2005 |
A randomized, double-blind, placebo-controlled trial of abciximab for prevention of in-stent restenosis in diabetic patients after coronary stenting: results of the ASIAD (Abciximab in Stenting Inhibits restenosis Among Diabetics) Trial.
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Blood Coagulation; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Restenosis; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Stents; Ticlopidine | 2005 |
Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene.
Topics: Adult; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Disease; Epinephrine; Female; Humans; Integrin alpha2; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2005 |
Effects of clopidogrel on the rebound hypercoagulable state after heparin discontinuation in patients with acute coronary syndromes.
Topics: Acute Disease; Angina, Unstable; Anticoagulants; Antithrombin III; Clopidogrel; Heparin; Humans; Myocardial Infarction; Peptide Fragments; Peptide Hydrolases; Platelet Aggregation Inhibitors; Prothrombin; Syndrome; Thrombophilia; Ticlopidine | 2005 |
Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect)
Topics: Administration, Oral; Aged; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Intestinal Absorption; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Stents; Ticlopidine | 2005 |
Could clopidogrel's platelet inhibition be enhanced by an increased loading dose and eptifibatide?
Topics: Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eptifibatide; Flow Cytometry; Follow-Up Studies; Humans; Myocardial Infarction; Myocardial Revascularization; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Secondary Prevention; Stents; Ticlopidine; Treatment Outcome | 2005 |
High stability of blood samples for flow cytometric analysis of VASP phosphorylation to measure the clopidogrel responsiveness in patients with coronary artery disease.
Topics: Aged; Aged, 80 and over; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; China; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2005 |
Clopidogrel diminishes hemodialysis access graft thrombosis.
Topics: Aged; Catheters, Indwelling; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polytetrafluoroethylene; Prospective Studies; Renal Dialysis; Thrombosis; Ticlopidine | 2006 |
Aspirin, warfarin and a thienopyridine for acute coronary syndromes.
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Hematologic Agents; Humans; Male; Pyridines; Risk Factors; Syndrome; Ticlopidine; Ventricular Function; Warfarin | 2006 |
Angiographic and clinical outcomes in patients receiving low-molecular-weight heparin versus unfractionated heparin in ST-elevation myocardial infarction treated with fibrinolytics in the CLARITY-TIMI 28 Trial.
Topics: Adolescent; Adult; Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Combination; Electrocardiography; Female; Fibrinolytic Agents; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Secondary Prevention; Ticlopidine; Treatment Outcome; Vascular Patency | 2005 |
Competency profile of locally manufactured clopidogrel Lowplat and foreign manufactured clopidogrel Plavix in patients of suspected ischemic heart disease (CLAP-IHD).
Topics: Administration, Oral; Adult; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drugs, Generic; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Pakistan; Platelet Aggregation Inhibitors; Retrospective Studies; Therapeutic Equivalency; Ticlopidine; Treatment Outcome; United States | 2005 |
Anti-inflammatory effects of clopidogrel intake in renal transplant patients: effects on platelet-leukocyte interactions, platelet CD40 ligand expression, and proinflammatory biomarkers.
Topics: Adult; Aged; Anti-Inflammatory Agents; Biomarkers; Blood Platelets; C-Reactive Protein; CD11b Antigen; CD40 Antigens; Chemokine CCL2; Clopidogrel; Female; Flow Cytometry; Humans; Immunosuppressive Agents; Inflammation; Kidney Transplantation; Leukocytes; Male; Matrix Metalloproteinase 9; Middle Aged; Monocytes; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Comparative effect of aspirin and clopidogrel on arterial function in CHF.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Chi-Square Distribution; Clopidogrel; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2006 |
Antiplatelets in stroke prevention: the MATCH trial. Some answers, many questions and countless perspectives.
Topics: Age Factors; Aged; Aspirin; Cerebrovascular Disorders; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2005 |
Benefit of clopidogrel according to timing of percutaneous coronary intervention in patients with acute coronary syndromes: further results from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Placebos; Platelet Aggregation Inhibitors; Recurrence; Survival Analysis; Ticlopidine; Treatment Outcome | 2005 |
[Indirect comparison of changes of parameters of hemostasis during short-term use of ticlopidine and clopidogrel in patients with non-ST elevation acute coronary syndrome].
Topics: Anticoagulants; Aspirin; Clopidogrel; Electrocardiography; Enoxaparin; Fibrinolysis; Fibrinolytic Agents; Hemostasis; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Syndrome; Thrombin; Ticlopidine; Time Factors | 2005 |
Enhanced antiplatelet effect of clopidogrel in patients whose platelets are least inhibited by aspirin: a randomized crossover trial.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Biomarkers; Clopidogrel; Collagen; Cross-Over Studies; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Peripheral Vascular Diseases; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome.
Topics: Acute Disease; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Premedication; Prospective Studies; Risk Factors; Secondary Prevention; Stents; Syndrome; Ticlopidine; Treatment Outcome | 2006 |
Anti-thrombotic action of clopidogrel and P1(A1/A2) polymorphism of beta3 integrin in patients with coronary artery disease not being treated with aspirin.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Genotype; Humans; Integrin beta3; Male; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Prothrombin; Thrombosis; Ticlopidine; Time Factors | 2005 |
Effect of aspirin, clopidogrel and dipyridamole on soluble markers of vascular function in normal volunteers and patients with prior ischaemic stroke.
Topics: Adult; Arteriosclerosis; Aspirin; Biomarkers; Blood Platelets; Brain Ischemia; C-Reactive Protein; Clopidogrel; Cross-Sectional Studies; Dipyridamole; Double-Blind Method; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Platelet Count; Platelet-Derived Growth Factor; Solubility; Stroke; Ticlopidine; Treatment Outcome; von Willebrand Factor | 2006 |
Effect of combined administration of clopidogrel and lysine acetylsalicylate versus clopidogrel and aspirin on platelet aggregation and activated GPIIb/IIIa expression in healthy volunteers.
Topics: Adult; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Humans; Lysine; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Reference Values; Ticlopidine | 2006 |
Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease.
Topics: Aged; Biomarkers; C-Reactive Protein; CD40 Ligand; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Effect of aspirin plus clopidogrel on inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome.
Topics: Adult; Aged; Angina, Unstable; Aspirin; C-Reactive Protein; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Female; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Ticlopidine; Tumor Necrosis Factor-alpha | 2006 |
Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination.
Topics: Adenosine Diphosphate; Antigens, Human Platelet; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Cytoplasmic Granules; Epinephrine; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Ticlopidine | 2006 |
Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin.
Topics: Adenosine; Administration, Oral; Adult; Aged; Aged, 80 and over; Aspirin; Atherosclerosis; Bleeding Time; Clopidogrel; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Postmenopause; Ticagrelor; Ticlopidine | 2006 |
Early administration of clopidogrel is safe after off-pump coronary artery bypass surgery.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass, Off-Pump; Critical Care; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Period; Reoperation; Retrospective Studies; Ticlopidine; Treatment Outcome | 2006 |
Pre-treatment with clopidogrel and postprocedure troponin elevation after elective percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Evaluation; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Multivariate Analysis; Premedication; Prospective Studies; Risk Factors; Ticlopidine; Troponin | 2006 |
A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension.
Topics: Adult; Aspirin; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2; Ticlopidine | 2006 |
Optimal timing for the initiation of pre-treatment with 300 mg clopidogrel before percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Ticlopidine; Time Factors | 2006 |
Antithrombotic effects of ximelagatran plus acetylsalicylic acid (ASA) and clopidogrel plus ASA in a human ex vivo arterial thrombosis model.
Topics: Administration, Oral; Adult; Anticoagulants; Arteries; Aspirin; Azetidines; Benzylamines; Bleeding Time; Blood Coagulation; Clopidogrel; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thrombosis; Ticlopidine | 2006 |
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Data Interpretation, Statistical; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke; Thrombosis; Ticlopidine | 2006 |
Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial.
Topics: Abciximab; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Double-Blind Method; Electrocardiography; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk; Survival Analysis; Ticlopidine; Troponin T | 2006 |
A prospective randomized antiplatelet trial of cilostazol versus clopidogrel in patients with bare metal stent.
Topics: Adult; Aged; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Disease; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tetrazoles; Ticlopidine | 2006 |
Single high-dose bolus tirofiban with high-loading-dose clopidogrel in primary coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2006 |
Monitoring platelet inhibition after clopidogrel with the VerifyNow-P2Y12(R) rapid analyzer: the VERIfy Thrombosis risk ASsessment (VERITAS) study.
Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Blood Platelets; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Stents; Thrombosis; Ticlopidine | 2007 |
Can clopidogrel and aspirin lower mortality in patients with acute myocardial infarction?
Topics: Aged; Aspirin; Clopidogrel; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Emergency Medical Services; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Probability; Severity of Illness Index; Survival Rate; Ticlopidine; Treatment Outcome | 2006 |
Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Integrin beta3; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Ticlopidine | 2007 |
The influence of body mass index on outcomes and the benefit of antiplatelet therapy following percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Body Mass Index; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Regression Analysis; Ticlopidine; Time Factors; Treatment Outcome | 2006 |
Whole blood aggregometry for evaluation of the antiplatelet effects of clopidogrel.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Monitoring, Physiologic; Platelet Aggregation; Platelet Function Tests; Predictive Value of Tests; Ticlopidine; Whole Blood Coagulation Time | 2007 |
Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease.
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2006 |
Is delayed facilitated percutaneous coronary intervention better than immediate in reperfused myocardial infarction? Six months follow up findings.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Time Factors; Tissue Plasminogen Activator | 2006 |
Biological effects of aspirin and clopidogrel in a randomized cross-over study in 96 healthy volunteers.
Topics: Adolescent; Adult; Aspirin; Blood Coagulation Tests; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thromboxane B2; Ticlopidine; Treatment Outcome | 2006 |
Cardiac events after low osmolar ionic or isosmolar nonionic contrast media utilization in the current era of coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Contrast Media; Coronary Angiography; Drug Delivery Systems; Enoxaparin; Female; Humans; Incidence; Ioxaglic Acid; Male; Middle Aged; Osmolar Concentration; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Risk Factors; Stents; Thrombosis; Ticlopidine; Triiodobenzoic Acids | 2006 |
Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: evidence for antioxidant and antiinflammatory effects.
Topics: Acetylcholine; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Biological Availability; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Humans; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Ticlopidine; Vasodilation; Vasodilator Agents | 2006 |
A comparison of dual vs. triple antiplatelet therapy in patients with non-ST-segment elevation acute coronary syndrome: results of the ELISA-2 trial.
Topics: Aged; Aspirin; Clopidogrel; Disease-Free Survival; Drug Combinations; Enzymes; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2006 |
Overcoming aspirin resistance: increased platelet inhibition with combination aspirin and clopidogrel and high dose aspirin therapy in aspirin resistant patients with peripheral vascular disease.
Topics: Aged; Aged, 80 and over; Arterial Occlusive Diseases; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2006 |
Platelet inhibition with prasugrel (CS-747) compared with clopidogrel in patients undergoing coronary stenting: the subset from the JUMBO study.
Topics: Clopidogrel; Coronary Disease; Female; Flow Cytometry; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Stents; Thiophenes; Ticlopidine | 2006 |
Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel.
Topics: Aged; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Embolism, Cholesterol; Enzyme Inhibitors; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Thrombosis; Ticlopidine | 2006 |
A comparison of pharmacologic therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Drug Therapy, Combination; Enoxaparin; Feasibility Studies; Female; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Tenecteplase; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator | 2006 |
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Biphenyl Compounds; Clopidogrel; Drug Therapy, Combination; Humans; International Normalized Ratio; Irbesartan; Platelet Aggregation Inhibitors; Risk Factors; Severity of Illness Index; Stroke; Tetrazoles; Ticlopidine | 2006 |
Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy.
Topics: Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Humans; Male; Observer Variation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prospective Studies; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2006 |
Rationale and design of ACTIVE: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Atrial Fibrillation; Biphenyl Compounds; Clopidogrel; Double-Blind Method; Female; Humans; Irbesartan; Male; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Research Design; Tetrazoles; Ticlopidine | 2006 |
Abciximab and angiographic restenosis after coronary stent placement. Analysis of the angiographic substudy of ISAR-REACT--a double-blind, placebo-controlled, randomized trial evaluating abciximab in patients undergoing elective percutaneous coronary inte
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Coronary Angiography; Coronary Restenosis; Double-Blind Method; Female; Humans; Immunoglobulin Fab Fragments; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2006 |
[Therapy of acute mayocardial infarction: COMMIT (Clopidogrel and Metoprolol Infarction Trial)].
Topics: Administration, Oral; Antihypertensive Agents; China; Clopidogrel; Drug Combinations; Humans; Metoprolol; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Survival Analysis; Survival Rate; Ticlopidine; Treatment Outcome | 2006 |
[Short-term outcomes of triple antiplatelet therapy after percutaneous coronary intervention].
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Period; Retrospective Studies; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2006 |
Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications.
Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Cohort Studies; Double-Blind Method; Esomeprazole; Female; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Secondary Prevention; Stomach Ulcer; Ticlopidine; Treatment Outcome | 2006 |
Delayed thrombin-induced platelet-fibrin clot generation by clopidogrel: a new dose-related effect demonstrated by thrombelastography in patients undergoing coronary artery stenting.
Topics: Aged; Anticoagulants; Aspirin; Blood Coagulation; Clopidogrel; Coronary Stenosis; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Reproducibility of Results; Stents; Thrombelastography; Thrombin; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
The role of clopidogrel in early and sustained arterial patency after fibrinolysis for ST-segment elevation myocardial infarction: the ECG CLARITY-TIMI 28 Study.
Topics: Aged; Clopidogrel; Coronary Circulation; Double-Blind Method; Electrocardiography; Female; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Survival Rate; Thrombolytic Therapy; Ticlopidine | 2006 |
Desensitization for the management of clopidogrel hypersensitivity: initial clinical experience.
Topics: Adult; Aged; Clopidogrel; Coronary Disease; Desensitization, Immunologic; Dose-Response Relationship, Drug; Drug Hypersensitivity; Exanthema; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Time Factors | 2006 |
Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel.
Topics: Adult; Aged; Clopidogrel; Drug Interactions; Humans; Linear Models; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Reproducibility of Results; Ticlopidine | 2006 |
Angiographically evident thrombus following fibrinolytic therapy is associated with impaired myocardial perfusion in STEMI: a CLARITY-TIMI 28 substudy.
Topics: Adolescent; Adult; Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Double-Blind Method; Drug Combinations; Fibrinolytic Agents; Humans; Microcirculation; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Ticlopidine | 2006 |
Clopidogrel increases expression of chemokines in peripheral blood mononuclear cells in patients with coronary artery disease: results of a double-blind placebo-controlled study.
Topics: Aged; Cells, Cultured; Chemokines; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Endothelium, Vascular; Female; Gene Expression Regulation; Humans; Immunoenzyme Techniques; Leukocytes, Mononuclear; Male; Middle Aged; Placebos; Platelet Aggregation Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Ticlopidine | 2006 |
Randomized comparison of the effects of ASA plus clopidogrel versus ASA alone on early platelet activation in acute coronary syndromes with elevated high-sensitivity C-reactive protein and soluble CD40 ligand levels.
Topics: Acute Disease; Aged; Angina, Unstable; Aspirin; C-Reactive Protein; CD40 Ligand; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Myocardial Infarction; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Risk Factors; Single-Blind Method; Syndrome; Ticlopidine | 2006 |
[Effectiveness and safety of clopidogrel bisulfate in complex therapy of patients with acute coronary syndrome with ST segment elevation].
Topics: Acute Disease; Angina Pectoris, Variant; Clopidogrel; Echocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine; Treatment Outcome | 2006 |
Erythrocyte deformability and white blood cell count are associated with aspirin resistance in high-risk vascular patients.
Topics: Aged; Angina, Unstable; Aspirin; Bleeding Time; Blood Viscosity; Clopidogrel; Drug Resistance; Erythrocyte Deformability; Female; Hemorheology; Humans; Leukocyte Count; Leukocytes; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2006 |
Clopidogrel is associated with a lesser increase in NT-proBNP when compared to aspirin in patients with ischemic heart failure.
Topics: Aged; Aged, 80 and over; Aspirin; Cardiac Output, Low; Clopidogrel; Cross-Over Studies; Disease Progression; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Natriuretic Peptide, Brain; Peptide Fragments; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Effects of aspirin and clopidogrel on plasma brain natriuretic peptide in patients with heart failure receiving ACE inhibitors.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Aspirin; Clopidogrel; Female; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Prostaglandins; Ticlopidine | 2007 |
Onset and offset of platelet inhibition after high-dose clopidogrel loading and standard daily therapy measured by a point-of-care assay in healthy volunteers.
Topics: Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Recovery of Function; Reference Values; Ticlopidine | 2006 |
Effects of ad hoc clopidogrel loading versus pre-treatment on P-selectin expression after coronary stent implantation.
Topics: Clopidogrel; Drug Delivery Systems; Flow Cytometry; Humans; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2006 |
Diabetes mellitus and platelet function after administration of aspirin and a single 600 mg dose of clopidogrel.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Diabetes Complications; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Thrombin; Thrombosis; Ticlopidine | 2006 |
Aspirin in peripheral arterial disease: breakthrough or pitfall?
Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Collateral Circulation; Combined Modality Therapy; Contraindications; Double-Blind Method; Exercise Test; Germany; Humans; Intermittent Claudication; Neovascularization, Physiologic; Physical Therapy Modalities; Platelet Aggregation Inhibitors; Prospective Studies; Switzerland; Ticlopidine | 2006 |
Quality of life improvement after hospital- based rehabilitation or home-based physical training in intermittent claudication.
Topics: Aged; Ambulatory Care; Clopidogrel; Combined Modality Therapy; Exercise Test; Female; Fibrinolytic Agents; Follow-Up Studies; Hospitalization; Humans; Intermittent Claudication; Male; Middle Aged; Outcome and Process Assessment, Health Care; Pilot Projects; Quality of Life; Rehabilitation Centers; Surveys and Questionnaires; Ticlopidine | 2006 |
A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) t
Topics: Acute Disease; Adenosine Diphosphate; Aged; Biomarkers; Clopidogrel; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Platelet Aggregation; Platelet Aggregation Inhibitors; Single-Blind Method; Ticlopidine; Troponin I | 2006 |
Recombinant factor VIIa reverses the inhibitory effect of aspirin or aspirin plus clopidogrel on in vitro thrombin generation.
Topics: Adult; Aged; Aspirin; Blood Coagulation Tests; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Factor VIIa; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Function Tests; Recombinant Proteins; Thrombin; Ticlopidine | 2006 |
Thromboelastography: potential bedside tool to assess the effects of antiplatelet therapy?
Topics: Adult; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Thrombelastography; Thrombosis; Ticlopidine; Time Factors | 2006 |
Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infar
Topics: Acute Disease; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Research Design; Syndrome; Thiophenes; Thrombolytic Therapy; Thrombosis; Ticlopidine; Treatment Outcome | 2006 |
Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance'.
Topics: Adenosine Diphosphate; Adult; Aspirin; Bayes Theorem; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Resistance; Female; Humans; Male; Middle Aged; Models, Cardiovascular; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Reference Values; Severity of Illness Index; Ticlopidine; Time Factors | 2007 |
Effects of Erigeron injection on vascular endothelium in patients after intracoronary stenting.
Topics: C-Reactive Protein; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Endothelin-1; Endothelium, Vascular; Erigeron; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Nitric Oxide; Phytotherapy; Plant Preparations; Platelet Aggregation Inhibitors; Stents; Superoxide Dismutase; Ticlopidine | 2006 |
Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Disease-Free Survival; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Regression Analysis; Stents; Ticlopidine; Treatment Failure | 2006 |
Quantifying the effect of antiplatelet therapy: a comparison of the platelet function analyzer (PFA-100) and modified thromboelastography (mTEG) with light transmission platelet aggregometry.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Atorvastatin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Light; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Pyrroles; Surgical Procedures, Operative; Thrombelastography; Ticlopidine | 2006 |
The role of aspirin resistance on outcome in patients with acute coronary syndrome and the effect of clopidogrel therapy in the prevention of major cardiovascular events.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Ticlopidine; Treatment Outcome | 2006 |
Pharmacodynamic interaction studies of Ginkgo biloba with cilostazol and clopidogrel in healthy human subjects.
Topics: Cilostazol; Clopidogrel; Cross-Over Studies; Ginkgo biloba; Herb-Drug Interactions; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Tetrazoles; Ticlopidine | 2007 |
Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Stents; Ticlopidine; Treatment Outcome | 2006 |
Percutaneous implantation of the CoreValve self-expanding valve prosthesis in high-risk patients with aortic valve disease: the Siegburg first-in-man study.
Topics: Aged; Aged, 80 and over; Aortic Valve; Aortic Valve Insufficiency; Aortic Valve Stenosis; Bioprosthesis; Clopidogrel; Echocardiography; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Hemodynamics; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Stents; Thrombocytopenia; Ticlopidine; Treatment Outcome | 2006 |
A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans.
Topics: Adolescent; Adult; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2007 |
No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease.
Topics: Aspirin; Biomarkers; Chemokine CCL2; Clopidogrel; Coronary Disease; Humans; Inflammation; Ticlopidine; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
[Prevention of atherothrombotic incidents. CHARISMA Study (The Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance].
Topics: Aged; Aspirin; Cause of Death; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Embolism, Cholesterol; Female; Humans; Intracranial Embolism; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2006 |
Impact of P-glycoprotein on clopidogrel absorption.
Topics: Administration, Oral; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Cell Membrane Permeability; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression; Genotype; Humans; Intestinal Absorption; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; RNA, Messenger; Ticlopidine | 2006 |
Efficacy and safety of clopidogrel 600 mg administered pre-hospitally to improve primary percutaneous coronary intervention in patients with acute myocardial infarction (CIPAMI): study rationale and design.
Topics: Adult; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Administration Schedule; Enoxaparin; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Research Design; Ticlopidine; Treatment Outcome | 2007 |
Effect of antiplatelet agents clopidogrel, aspirin, and cilostazol on circulating tissue factor procoagulant activity in patients with peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Antithrombin III; Aspirin; Blood Platelets; C-Reactive Protein; CD40 Ligand; Cell Membrane; Cilostazol; Clopidogrel; Down-Regulation; Drug Therapy, Combination; Factor VIIa; Humans; Middle Aged; P-Selectin; Peptide Fragments; Peptide Hydrolases; Peripheral Vascular Diseases; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Prothrombin; Tetrazoles; Thromboplastin; Ticlopidine | 2006 |
Naproxen treatment prevents periprocedural inflammatory response but not myocardial injury after percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; C-Reactive Protein; Clopidogrel; Creatine Kinase, MB Form; Drug Combinations; Female; Follow-Up Studies; Humans; Inflammation; Intraoperative Period; Male; Middle Aged; Myocardial Infarction; Naproxen; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome; Troponin I | 2007 |
Prehospital fibrinolysis with dual antiplatelet therapy in ST-elevation acute myocardial infarction: a substudy of the randomized double blind CLARITY-TIMI 28 trial.
Topics: Aged; Ambulances; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Emergency Medical Services; Female; Fibrinolysis; Hemorrhage; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2007 |
Effect of clopidogrel with and without eptifibatide on tumor necrosis factor-alpha and C-reactive protein release after elective stenting: results from the CLEAR PLATELETS 1b study.
Topics: Aged; Biomarkers; Blood Platelets; C-Reactive Protein; Clopidogrel; Creatine Kinase, MB Form; Eptifibatide; Female; Flow Cytometry; Humans; Inflammation; Male; Middle Aged; Myocardial Ischemia; Myocardium; Necrosis; P-Selectin; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine; Tumor Necrosis Factor-alpha | 2006 |
Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: an observational study of drug-eluting versus bare-metal stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug Delivery Systems; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine | 2006 |
A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.
Topics: Adult; Area Under Curve; Blood Platelets; Clopidogrel; Cross-Over Studies; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticlopidine | 2007 |
Clopidogrel bisulfate: in ST-segment elevation myocardial infarction: a viewpoint by Jeffrey W Moses.
Topics: Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Complementary effects of thienopyridine pretreatment and platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention; results from the ESPRIT trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Eptifibatide; Female; Hemorrhage; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Retrospective Studies; Risk Assessment; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study.
Topics: Aged; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Dilatation, Pathologic; Double-Blind Method; Endothelium, Vascular; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Superoxides; Ticlopidine | 2008 |
Effect of food on bioavailability of a single oral dose of clopidogrel in healthy male subjects.
Topics: Adult; Area Under Curve; Biological Availability; Calibration; Clopidogrel; Cross-Over Studies; Electrocardiography; Food-Drug Interactions; Half-Life; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Normalization of platelet reactivity in clopidogrel-treated subjects.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fibrinogen; Humans; Male; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Platelet-Rich Plasma; Postoperative Hemorrhage; Receptors, Thrombin; Recovery of Function; Reference Values; Ticlopidine; Time Factors | 2007 |
Effect of timing of clopidogrel administration on 30-day clinical outcomes: 300-mg loading dose immediately after coronary stenting versus pretreatment 6 to 24 hours before stenting in a large unselected patient cohort.
Topics: Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Myocardial Revascularization; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Registries; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Long-term versus short-term clopidogrel therapy in patients undergoing coronary stenting (from the Randomized Argentine Clopidogrel Stent [RACS] trial).
Topics: Aged; Angioplasty, Balloon, Coronary; Argentina; Clopidogrel; Coronary Angiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Stents; Survival Rate; Ticlopidine; Time Factors | 2007 |
Effect of atorvastatin and pravastatin on platelet inhibition by aspirin and clopidogrel treatment in patients with coronary stent thrombosis.
Topics: Aged; Aspirin; Atorvastatin; Clopidogrel; Coronary Restenosis; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Prospective Studies; Prosthesis Failure; Pyrroles; Stents; Ticlopidine; Treatment Outcome | 2007 |
Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2007 |
The flow cytometric VASP assay can be used to determine the effectiveness of clopidogrel in patients treated with abciximab.
Topics: Abciximab; Angina Pectoris; Animals; Antibodies, Monoclonal; Anticoagulants; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Flow Cytometry; Hematologic Tests; Humans; Immunoglobulin Fab Fragments; Mice; Microfilament Proteins; Phosphoproteins; Platelet Function Tests; Regression Analysis; Reproducibility of Results; Ticlopidine | 2007 |
Lack of association between the 807 C/T polymorphism of glycoprotein Ia gene and post-treatment platelet reactivity after aspirin and clopidogrel in patients with acute coronary syndrome.
Topics: Acute Disease; Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cytosine; Female; France; Genotype; Humans; Integrin alpha2; Male; Microfilament Proteins; Middle Aged; Myocardial Ischemia; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Prospective Studies; Syndrome; Thymine; Ticlopidine; Treatment Outcome | 2007 |
A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days.
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thromboembolism; Thrombosis; Ticlopidine | 2007 |
Response to aspirin and clopidogrel in patients scheduled to undergo cardiovascular surgery.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Preoperative Care; Ticlopidine; Treatment Outcome | 2007 |
Clinical relevance of aspirin resistance in patients with stable coronary artery disease: a prospective follow-up study (PROSPECTAR).
Topics: Aged; Angina Pectoris; Aspirin; Clopidogrel; Coronary Artery Disease; Death; Drug Resistance; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Function Tests; Prevalence; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome | 2007 |
A novel enoxaparin regime for ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: a WEST sub-study.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Canada; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Enoxaparin; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Injections, Intravenous; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Treatment Outcome; Urban Population | 2007 |
Benefits and risks of clopidogrel pretreatment before coronary artery bypass grafting in patients with ST-elevation myocardial infarction treated with fibrinolytics in CLARITY-TIMI 28.
Topics: Aged; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Perioperative Care; Premedication; Risk Assessment; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2007 |
Rationale, design and baseline data of a randomized, double-blind, controlled trial comparing two antithrombotic regimens (a fixed-dose combination of extended-release dipyridamole plus ASA with clopidogrel) and telmisartan versus placebo in patients with
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Benzimidazoles; Benzoates; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Double-Blind Method; Drug Combinations; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Research Design; Secondary Prevention; Stroke; Telmisartan; Ticlopidine; Treatment Outcome | 2007 |
[Influence of the double antiplatelet therapy on patency of the occluded artery after acute myocardial infarction with ST-segment elevation].
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Electrocardiography; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine; Vascular Patency | 2007 |
Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently.
Topics: Adult; Area Under Curve; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP3A Inhibitors; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2007 |
Relation between impaired antiplatelet response to clopidogrel and possible pleiotropic effects.
Topics: Aged; Aspirin; Blood Platelets; C-Reactive Protein; Clopidogrel; Drug Resistance; Female; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine | 2007 |
Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aspirin; Bleeding Time; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2007 |
Comparison of three-year clinical outcome of sirolimus- and paclitaxel-eluting stents versus bare metal stents in patients with ST-segment elevation myocardial infarction (from the RESEARCH and T-SEARCH Registries).
Topics: Angioplasty, Balloon, Coronary; Cause of Death; Clopidogrel; Cohort Studies; Coronary Restenosis; Electrocardiography; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Registries; Retrospective Studies; Sirolimus; Stents; Survival Rate; Ticlopidine; Treatment Outcome | 2007 |
Safety of sirolimus-eluting stenting and its effect on restenosis in patients with unstable angina pectoris (a SIRIUS substudy).
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Double-Blind Method; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retreatment; Retrospective Studies; Safety; Sirolimus; Stents; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Comparison of two antiplatelet regimens (aspirin alone versus aspirin + ticlopidine or clopidogrel) after intracoronary implantation of a carbofilm-coated stent.
Topics: Aspirin; Carbon; Cause of Death; Clopidogrel; Coated Materials, Biocompatible; Coronary Disease; Coronary Restenosis; Coronary Thrombosis; Drug Combinations; Equipment Design; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Reoperation; Stents; Ticlopidine; Treatment Outcome | 2007 |
Effect of clopidogrel on the steady-state pharmacokinetics of fluvastatin.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C9; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
[The effect of different loading doses of clopidogrel on platelet aggregation].
Topics: Adult; Aged; Angina, Unstable; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Ticlopidine | 2007 |
Renal function and outcomes in acute coronary syndrome: impact of clopidogrel.
Topics: Aged; Angina, Unstable; Clopidogrel; Coronary Disease; Creatinine; Double-Blind Method; Female; Glomerular Filtration Rate; Hemorrhage; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Research Design; Risk Factors; Severity of Illness Index; Survival Analysis; Syndrome; Ticlopidine; Treatment Outcome | 2007 |
Platelet function in clopidogrel-treated patients with acute coronary syndrome.
Topics: Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Treatment Outcome | 2007 |
Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial.
Topics: Aged; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2007 |
Influence of antiplatelet therapy on cerebral micro-emboli after carotid endarterectomy using postoperative transcranial Doppler monitoring.
Topics: Aged; Anticoagulants; Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Dextrans; Dipyridamole; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Hemorrhage; Humans; Intracranial Embolism; Ischemic Attack, Transient; Male; Middle Aged; Middle Cerebral Artery; Pilot Projects; Platelet Aggregation Inhibitors; Postoperative Care; Prospective Studies; Stroke; Ticlopidine; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2007 |
Efficacy and safety of enoxaparin versus unfractionated heparin in patients with ST-segment elevation myocardial infarction also treated with clopidogrel.
Topics: Aged; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Enoxaparin; Female; Fibrinolytic Agents; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2007 |
[Absence of benefit with triple antiaggregation in acute non persistent ST segment elevation myocardial infarction in patients not subjected to early interventionism].
Topics: Aged; Aspirin; Clopidogrel; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Tirofiban; Tyrosine | 2007 |
Long-term clinical benefit of sirolimus-eluting stent implantation in diabetic patients with de novo coronary stenoses: long-term results of the DIABETES trial.
Topics: Aged; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Death, Sudden, Cardiac; Diabetic Angiopathies; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prospective Studies; Prosthesis Failure; Reoperation; Sirolimus; Ticlopidine; Treatment Outcome | 2007 |
Effects of persistent platelet reactivity despite aspirin therapy on cardiac troponin I and creatine kinase-MB levels after elective percutaneous coronary interventions.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Clopidogrel; Coronary Artery Disease; Creatine Kinase, MB Form; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardium; Necrosis; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Tablets, Enteric-Coated; Thrombosis; Ticlopidine; Time Factors; Troponin I; Up-Regulation | 2008 |
Association of interleukin-10 level with increased 30-day mortality in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention.
Topics: Aged; Angioplasty, Balloon; Clopidogrel; Cohort Studies; Electrocardiography; Female; Humans; Interleukin-10; Male; Middle Aged; Mortality; Myocardial Infarction; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prognosis; Prospective Studies; Risk Factors; Stents; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Tyrosine | 2007 |
The additive antiplatelet action of clopidogrel in patients with coronary artery disease treated with aspirin.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Biomarkers; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2007 |
Effects of preoperative aspirin and clopidogrel therapy on perioperative blood loss and blood transfusion requirements in patients undergoing off-pump coronary artery bypass graft surgery.
Topics: Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Premedication; Prospective Studies; Ticlopidine | 2007 |
Prolonged dual antiplatelet therapy after percutaneous coronary intervention reduces ischemic events without affecting the need for repeat revascularization: insights from the CREDO trial.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Contraindications; Coronary Restenosis; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Revascularization; Platelet Aggregation Inhibitors; Postoperative Care; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Transitioning patients from cangrelor to clopidogrel: pharmacodynamic evidence of a competitive effect.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adolescent; Adult; Clopidogrel; Cyclooxygenase Inhibitors; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2008 |
Quality assessment of platelet rich plasma during anti-platelet therapy.
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Platelet Transfusion; Quality Assurance, Health Care; Surgical Procedures, Operative; Ticlopidine; Wound Healing | 2007 |
Oral anticoagulant and antiplatelet therapy and peripheral arterial disease.
Topics: Acenocoumarol; Administration, Oral; Anticoagulants; Aspirin; Atherosclerosis; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2007 |
Optimal platelet inhibition in patients undergoing PCI: data from the Multicenter Registry of High-Risk Percutaneous Coronary Intervention and Adequate Platelet Inhibition (MR PCI) study.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Eptifibatide; Humans; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Registries; Ticlopidine; Tirofiban; Tyrosine | 2007 |
Therapeutic benefit of low-dose clopidogrel in patients undergoing carotid surgery is linked to variability in the platelet adenosine diphosphate response and patients' weight.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Body Weight; Clopidogrel; Endarterectomy, Carotid; Humans; Placebos; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Statistics as Topic; Thrombosis; Ticlopidine | 2007 |
Lack of evidence of a clopidogrel-statin interaction in the CHARISMA trial.
Topics: Atorvastatin; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Pravastatin; Prospective Studies; Pyrroles; Ticlopidine | 2007 |
An analysis of mortality rates with dual-antiplatelet therapy in the primary prevention population of the CHARISMA trial.
Topics: Aged; Aspirin; Atherosclerosis; Cardiovascular Diseases; Clopidogrel; Disease-Free Survival; Drug Therapy, Combination; Epidemiologic Methods; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2007 |
Effects of triple antiplatelet therapy (aspirin, clopidogrel, and cilostazol) on platelet aggregation and P-selectin expression in patients undergoing coronary artery stent implantation.
Topics: Aspirin; Biomarkers; Blood Vessel Prosthesis Implantation; Cilostazol; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Drug Therapy, Combination; Female; Flow Cytometry; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Revascularization; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Preoperative Care; Radiography; Stents; Tetrazoles; Ticlopidine; Treatment Outcome | 2007 |
The paclitaxel-eluting Coroflex Please stent pilot study (PECOPS I) : the one-year clinical follow-up.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Death; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Paclitaxel; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Survival Rate; Thrombosis; Ticlopidine; Tubulin Modulators | 2007 |
Effects of recombinant human erythropoietin on antiplatelet action of aspirin and clopidogrel in healthy subjects: results of a double-blind, placebo-controlled randomized trial.
Topics: Adult; Aspirin; Blood Platelets; Clopidogrel; Double-Blind Method; Erythropoietin; Female; Humans; Male; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine | 2007 |
Hypercoagulability and platelet inhibition after OPCAB. Randomized intervention with clopidogrel.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Thrombelastography; Thromboembolism; Thrombophilia; Ticlopidine | 2007 |
ExTRACT-TIMI 25 trial: clarifying the role of enoxaparin in patients with ST-elevation myocardial infarction receiving fibrinolysis.
Topics: Adult; Age Factors; Aged; Clopidogrel; Double-Blind Method; Enoxaparin; Female; Fibrinolytic Agents; Heart Conduction System; Heparin, Low-Molecular-Weight; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Risk Factors; Survival Analysis; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2007 |
Efficacy and safety of triple antiplatelet therapy with and without concomitant anticoagulation during elective percutaneous coronary intervention (the REMOVE trial).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Eptifibatide; Female; Heparin; Humans; Male; Middle Aged; Peptides; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Pyridines; Ticlopidine; Treatment Outcome | 2007 |
Comparison of triple versus dual antiplatelet therapy after drug-eluting stent implantation (from the DECLARE-Long trial).
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Drug Delivery Systems; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome; Tunica Intima | 2007 |
Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial.
Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Ischemic Attack, Transient; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Risk Reduction Behavior; Secondary Prevention; Severity of Illness Index; Simvastatin; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
TAXUS VI 2-year follow-up: randomized comparison of polymer-based paclitaxel-eluting with bare metal stents for treatment of long, complex lesions.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Epidemiologic Methods; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Revascularization; Paclitaxel; Platelet Aggregation Inhibitors; Polymers; Ticlopidine | 2007 |
Relationship between platelet count and 30-day clinical outcomes after percutaneous coronary interventions. Pooled analysis of four ISAR trials.
Topics: Abciximab; Acute Coronary Syndrome; Aged; Angiography; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Blood Platelets; Clopidogrel; Diabetes Complications; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Count; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
A novel fifteen minute test for assessment of individual time-dependent clotting responses to aspirin and clopidogrel using modified thrombelastography.
Topics: Adult; Aged; Aspirin; Blood Coagulation; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Reproducibility of Results; Thrombelastography; Ticlopidine | 2007 |
To adjust or not to adjust the platelet count in light transmission aggregometry in patients receiving dual aspirin/clopidogrel treatment.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Platelet-Rich Plasma; Prospective Studies; Reproducibility of Results; Ticlopidine | 2007 |
[The changes and effects of antiplatelet agents on platelet-leukocyte aggregation in patients with acute cerebral infarction].
Topics: Aged; Aspirin; C-Reactive Protein; Cerebral Infarction; Clopidogrel; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2007 |
Effect of cilostazol on in-stent neointimal hyperplasia after coronary artery stenting: a quantative coronary angiography and volumetric intravascular ultrasound study.
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Vessels; Drug Therapy, Combination; Female; Humans; Hyperplasia; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tetrazoles; Ticlopidine; Tunica Intima; Ultrasonography, Interventional | 2007 |
Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSE-2 tri
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticagrelor; Ticlopidine | 2007 |
Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Administration, Oral; Aged; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2007 |
Prasugrel versus clopidogrel in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Stroke; Thiophenes; Thrombosis; Ticlopidine | 2007 |
Cost-effectiveness of clopidogrel in acute coronary syndromes in Canada: a long-term analysis based on the CURE trial.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Canada; Clopidogrel; Cost of Illness; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Hospitalization; Humans; Length of Stay; Life Expectancy; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Ticlopidine; Time Factors | 2007 |
Prevalence and risk factors for aspirin and clopidogrel resistance in cerebrovascular stenting.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Vessel Prosthesis; Cerebrovascular Disorders; Clopidogrel; Cohort Studies; Comorbidity; Drug Resistance; Female; Graft Occlusion, Vascular; Humans; Illinois; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Stents; Ticlopidine | 2008 |
Clopidogrel desensitization after drug-eluting stent placement.
Topics: Clopidogrel; Coronary Artery Disease; Desensitization, Immunologic; Drug Hypersensitivity; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2007 |
Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel.
Topics: Adenosine Diphosphate; Adult; Area Under Curve; Blood Platelets; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2007 |
A randomized, double-blind study comparing the safety and efficacy of clopidogrel versus ticlopidine in Japanese patients with noncardioembolic cerebral infarction.
Topics: Aged; Cerebral Infarction; Clopidogrel; Disease-Free Survival; Double-Blind Method; Female; Humans; Japan; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2008 |
Incidence of stroke in paroxysmal versus sustained atrial fibrillation in patients taking oral anticoagulation or combined antiplatelet therapy: an ACTIVE W Substudy.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Thromboembolism; Ticlopidine; Treatment Outcome | 2007 |
Cilostazol could ameliorate platelet responsiveness to clopidogrel in patients undergoing primary percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Platelets; CD40 Antigens; Cilostazol; Clopidogrel; Combined Modality Therapy; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Treatment Outcome | 2007 |
Troponin level and efficacy of abciximab in patients with acute coronary syndromes undergoing early intervention after clopidogrel pretreatment.
Topics: Abciximab; Acute Coronary Syndrome; Aged; Antibodies, Monoclonal; Biomarkers; Cardiovascular Surgical Procedures; Clopidogrel; Electrocardiography; Female; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Platelet Aggregation Inhibitors; Preoperative Care; Survival Analysis; Ticlopidine; Time Factors; Treatment Outcome; Troponin T | 2008 |
Comparison of the effects of pretreatment with tirofiban, clopidogrel or both on the inhibition of platelet aggregation and activation in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Animals; Clopidogrel; Drug Administration Schedule; Drug Synergism; Female; Humans; Infusions, Intravenous; Injections, Subcutaneous; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Tirofiban; Tyrosine | 2009 |
Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease.
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Treatment Outcome | 2008 |
Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Cross-Over Studies; Female; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2007 |
Effect of clopidogrel treatment on stress-induced platelet activation and myocardial ischemia in aspirin-treated patients with stable coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; C-Reactive Protein; CD40 Ligand; Clopidogrel; Collagen; Coronary Artery Disease; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Exercise Test; Flow Cytometry; Heart Rate; Humans; Interleukin-6; Leukocytes; Male; Middle Aged; Myocardial Ischemia; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Research Design; Stress, Physiological; Thrombin; Ticlopidine; Treatment Outcome | 2007 |
The significance of vasodilator-stimulated phosphoprotein for risk stratification of stent thrombosis.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cell Adhesion Molecules; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Research Design; Risk Assessment; Risk Factors; ROC Curve; Sensitivity and Specificity; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
[The antiplatelet effect of clopidogrel is not attenuated by statin treatment in patients with acute coronary syndromes undergone coronary stenting].
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Atorvastatin; Clopidogrel; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Prospective Studies; Pyrroles; Ticlopidine | 2007 |
[Effects of intensive antiplatelet therapy in patients with high platelet aggregability after percutaneous coronary intervention].
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Ticlopidine | 2007 |
Effects of clopidogrel and aspirin in combination versus aspirin alone on platelet activation and major receptor expression in diabetic patients: the PLavix Use for Treatment Of Diabetes (PLUTO-Diabetes) trial.
Topics: Adult; Analysis of Variance; Aspirin; Biomarkers; Blood Chemical Analysis; Clopidogrel; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Middle Aged; Myocardial Ischemia; Pilot Projects; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Probability; Prognosis; Receptor, PAR-2; Reference Values; Risk Assessment; Survival Rate; Ticlopidine; Treatment Outcome | 2008 |
Effects of pretreatment with clopidogrel on nonemergent percutaneous coronary intervention after fibrinolytic administration for ST-segment elevation myocardial infarction: a Clopidogrel as Adjunctive Reperfusion Therapy-Thrombolysis in Myocardial Infarct
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Double-Blind Method; Drug Administration Schedule; Elective Surgical Procedures; Electrocardiography; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Probability; Reference Values; Risk Assessment; Survival Rate; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2008 |
Evaluation of proton pump inhibitor use in patients with acute coronary syndromes based on risk factors for gastrointestinal bleed.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Female; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Proton Pump Inhibitors; Risk Factors; Ticlopidine; Treatment Outcome; Warfarin | 2007 |
Variable responsiveness to clopidogrel and aspirin among patients with acute coronary syndrome as assessed by platelet function tests.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet-Rich Plasma; ROC Curve; Sensitivity and Specificity; Ticlopidine | 2008 |
One-year clinical outcomes with abciximab vs. placebo in patients with non-ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention after pre-treatment with clopidogrel: results of the ISAR-REACT 2 randomized trial.
Topics: Abciximab; Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Double-Blind Method; Epidemiologic Methods; Female; Humans; Immunoglobulin Fab Fragments; Male; Myocardial Infarction; Perioperative Care; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2008 |
Randomized comparison of cilostazol vs clopidogrel after drug-eluting stenting in diabetic patients--clilostazol for diabetic patients in drug-eluting stent (CIDES) trial.
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Diabetes Complications; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Male; Middle Aged; Tetrazoles; Ticlopidine; Treatment Outcome | 2008 |
The effects of antiplatelet agents on platelet-leukocyte aggregations in patients with acute cerebral infarction.
Topics: Aged; Aspirin; Blood Platelets; Cell Adhesion; Cerebral Infarction; Clopidogrel; Female; Humans; Leukocytes; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE) biomarker sub-study.
Topics: Adult; Aged; Antidepressive Agents; Aspirin; beta-Thromboglobulin; Biomarkers; Blood Platelets; Citalopram; Clopidogrel; Comorbidity; Coronary Disease; Depressive Disorder, Major; Drug Interactions; Endothelium, Vascular; Female; Humans; Intercellular Adhesion Molecule-1; Male; Middle Aged; Nitric Oxide; P-Selectin; Platelet Aggregation Inhibitors; Psychotherapy; Selective Serotonin Reuptake Inhibitors; Ticlopidine; Young Adult | 2009 |
Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial.
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Hemorrhage; Humans; Infant; Infant, Newborn; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study.
Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Drug Antagonism; Drug Therapy, Combination; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Omeprazole; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Stents; Ticlopidine | 2008 |
Patients with non-ST-elevation acute coronary syndromes undergoing coronary artery bypass grafting in the modern era of antithrombotic therapy.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Artery Bypass; Electrocardiography; Enoxaparin; Female; Fibrinolytic Agents; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Hemorrhage; Survival Analysis; Ticlopidine; Treatment Outcome | 2008 |
Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Electrodes; Female; Humans; Light; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reproducibility of Results; Ticlopidine; Time Factors | 2008 |
Functional impact of high clopidogrel maintenance dosing in patients undergoing elective percutaneous coronary interventions. Results of a randomized study.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Florida; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Research Design; Spain; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Impact of cytochrome P450 3A4-metabolized statins on the antiplatelet effect of a 600-mg loading dose clopidogrel and on clinical outcome in patients undergoing elective coronary stent placement.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Atorvastatin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Coronary Disease; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Female; Flow Cytometry; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Pyrroles; Simvastatin; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
A comparison of the antiplatelet effects of prasugrel and high-dose clopidogrel as assessed by VASP-phosphorylation and light transmission aggregometry.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Flow Cytometry; Humans; Light; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reproducibility of Results; Thiophenes; Ticlopidine; Time Factors | 2008 |
Prevalence of platelet nonresponsiveness to aspirin in patients treated for secondary stroke prophylaxis and in patients with recurrent ischemic events.
Topics: Age Factors; Aged; Anti-Inflammatory Agents; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Dipyridamole; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Odds Ratio; Platelet Aggregation; Recurrence; Stroke; Ticlopidine; Time Factors; Treatment Failure | 2008 |
Association of blood glucose with angiographic and clinical outcomes among patients with ST-segment elevation myocardial infarction (from the CLARITY-TIMI-28 study).
Topics: Blood Glucose; Clopidogrel; Coronary Angiography; Female; Hospital Mortality; Humans; Hyperglycemia; Hypoglycemia; Logistic Models; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2008 |
Association of impaired thrombolysis in myocardial infarction myocardial perfusion grade with ventricular tachycardia and ventricular fibrillation following fibrinolytic therapy for ST-segment elevation myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Circulation; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Risk Factors; Tachycardia, Ventricular; Thrombolytic Therapy; Ticlopidine; Treatment Outcome; Ventricular Fibrillation | 2008 |
Platelet inhibition by low-dose aspirin but not by clopidogrel reduces the axon-reflex current-induced vasodilation in humans.
Topics: Acetylcholine; Adenosine Diphosphate; Adult; Aspirin; Axons; Blood Platelets; Clopidogrel; Electric Stimulation; Endothelium, Vascular; Female; Humans; Iontophoresis; Laser-Doppler Flowmetry; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Signal Transduction; Ticlopidine; Vasodilation; Vasodilator Agents | 2008 |
Sirolimus-eluting stents versus bare-metal stents in patients with ST-segment elevation myocardial infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Heparin; Humans; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Proportional Hazards Models; Sirolimus; Stents; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Interventional | 2008 |
The use of the VerifyNow P2Y12 point-of-care device to monitor platelet function across a range of P2Y12 inhibition levels following prasugrel and clopidogrel administration.
Topics: Adult; Aspirin; Blood Coagulation Tests; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reference Values; Reproducibility of Results; Thiophenes; Ticlopidine | 2008 |
Residual prothrombotic status in low responder patients to clopidogrel identified by Vasodilator-Stimulated Phosphoprotein Phosphorylation (VASP) analysis?
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aged, 80 and over; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Ischemia; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Recurrence; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
High-performance liquid chromatographic determination of inactive carboxylic acid metabolite of clopidogrel in human serum: Application to a bioequivalence study.
Topics: Acetonitriles; Adult; Carboxylic Acids; Chromatography, High Pressure Liquid; Clopidogrel; Drug Stability; Ethylamines; Humans; Male; Platelet Aggregation Inhibitors; Sensitivity and Specificity; Therapeutic Equivalency; Ticlopidine | 2008 |
Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Adolescent; Adult; Aged; Area Under Curve; Biological Availability; Clopidogrel; Cross-Over Studies; Drug Interactions; Female; Humans; Lansoprazole; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Thiophenes; Ticlopidine | 2008 |
Clopidogrel and aspirin versus aspirin alone for the prevention of stroke in patients with a history of atrial fibrillation: subgroup analysis of the CHARISMA randomized trial.
Topics: Aged; Aspirin; Atrial Fibrillation; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2008 |
Functional effects of high clopidogrel maintenance dosing in patients with inadequate platelet inhibition on standard dose treatment.
Topics: Aged; Clopidogrel; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2008 |
Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W).
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Anticoagulants; Aspirin; Atrial Fibrillation; Biphenyl Compounds; Cerebral Hemorrhage; Clinical Protocols; Clopidogrel; Drug Combinations; Drug Therapy, Combination; Female; Humans; Irbesartan; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome; Warfarin | 2008 |
Clopidogrel 600-mg double loading dose achieves stronger platelet inhibition than conventional regimens: results from the PREPAIR randomized study.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2008 |
Antiplatelet profiles of the fixed-dose combination of extended-release dipyridamole and low-dose aspirin compared with clopidogrel with or without aspirin in patients with type 2 diabetes and a history of transient ischemic attack: a randomized, single-b
Topics: Adult; Aged; Aspirin; Aspirin, Dipyridamole Drug Combination; Biomarkers; Clopidogrel; Diabetes Mellitus, Type 2; Dipyridamole; Drug Combinations; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Single-Blind Method; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Association between baseline neutrophil count, clopidogrel therapy, and clinical and angiographic outcomes in patients with ST-elevation myocardial infarction receiving fibrinolytic therapy.
Topics: Clopidogrel; Coronary Angiography; Epidemiologic Methods; Female; Humans; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Neutrophils; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2008 |
Platelet aggregation and recruitment with aspirin-clopidogrel therapy.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Thromboxane B2; Ticlopidine | 2008 |
Drug-eluting stenting followed by cilostazol treatment reduces late restenosis in patients with diabetes mellitus the DECLARE-DIABETES Trial (A Randomized Comparison of Triple Antiplatelet Therapy with Dual Antiplatelet Therapy After Drug-Eluting Stent Im
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Coronary Vessels; Diabetes Mellitus; Diabetic Angiopathies; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Hyperplasia; Male; Middle Aged; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Treatment Outcome; Tunica Intima | 2008 |
Effects of coronary prestenting platelet inhibition on coronary poststenting inflammation.
Topics: Aged; alpha 1-Antitrypsin; Clopidogrel; Drug Administration Schedule; Female; Humans; Inflammation; Infusions, Intravenous; Male; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine; Time Factors; Tirofiban; Tyrosine | 2008 |
Effect of tirofiban plus clopidogrel and aspirin on primary percutaneous coronary intervention via transradial approach in patients with acute myocardial infarction.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Tirofiban; Tyrosine; Vasodilation | 2008 |
The efficacy and safety of short- and long-term dual antiplatelet therapy in patients with mild or moderate chronic kidney disease: results from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Renal Insufficiency, Chronic; Stents; Ticlopidine; Treatment Outcome | 2008 |
Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomi
Topics: Acute Coronary Syndrome; Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: a multicenter randomized prospective study.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Humans; Male; Microfilament Proteins; Myocardial Infarction; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Vasodilation | 2008 |
The importance of anticoagulant agents in measuring platelet aggregation in patients treated with clopidogrel and aspirin.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Blood Platelets; Citrates; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Sodium Citrate; Ticlopidine | 2008 |
[Local hemostasis during the carotid endarterectomy under condition of antithrombocytic therapy].
Topics: Aged; Aprotinin; Blood Coagulation; Blood Loss, Surgical; Blood Volume; Carotid Stenosis; Clopidogrel; Drug Combinations; Endarterectomy, Carotid; Female; Fibrinogen; Fibrinolytic Agents; Hemostasis, Surgical; Humans; Male; Middle Aged; Thrombin; Ticlopidine; Treatment Outcome | 2007 |
[Removing phlegm and dispelling stasis method combined with Western medicine for treatment of cerebrovascular stenosis].
Topics: Adult; Aged; Aspirin; C-Reactive Protein; Carotid Stenosis; Cerebrovascular Disorders; Clopidogrel; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Fibrinogen; Humans; Male; Middle Aged; Phytotherapy; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2008 |
A novel bioresorbable polymer paclitaxel-eluting stent for the treatment of single and multivessel coronary disease: primary results of the COSTAR (Cobalt Chromium Stent With Antiproliferative for Restenosis) II study.
Topics: Absorbable Implants; Angioplasty, Balloon, Coronary; Antineoplastic Agents, Phytogenic; Chromium Alloys; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Polymers; Risk; Thromboembolism; Ticlopidine; Time Factors | 2008 |
[The TRITON-TIMI 38 trial].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Approaching an age of reason with antiplatelet therapy.
Topics: Clopidogrel; Coronary Disease; Humans; Membrane Proteins; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Effect of abciximab on clinical and angiographic restenosis in patients with non-ST-segment elevation acute coronary syndromes.
Topics: Abciximab; Acute Coronary Syndrome; Aged; Antibodies, Monoclonal; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Coronary Restenosis; Female; Humans; Immunoglobulin Fab Fragments; Male; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2008 |
High-dose atorvastatin does not negatively influence clinical outcomes among clopidogrel treated acute coronary syndrome patients--a Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) a
Topics: Acute Coronary Syndrome; Aged; Atorvastatin; Clopidogrel; Cytochrome P-450 Enzyme System; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine; Treatment Outcome | 2008 |
Clopidogrel pre-treatment in stable angina: for all patients > 6 h before elective coronary angiography or only for angiographically selected patients a few minutes before PCI? A randomized multicentre trial PRAGUE-8.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Chronic Disease; Clopidogrel; Coronary Angiography; Female; Follow-Up Studies; Humans; Male; Myocardial Infarction; Perioperative Care; Platelet Aggregation Inhibitors; Premedication; Risk Factors; Ticlopidine; Troponin | 2008 |
Pharmacokinetics of clopidogrel in patients with stent thrombosis.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Pharmacokinetics; Platelet Aggregation; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2008 |
Impact of bivalirudin or unfractionated heparin on platelet aggregation in patients pretreated with 600 mg clopidogrel undergoing elective percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Double-Blind Method; Female; Heparin; Hirudins; Humans; Male; Peptide Fragments; Perioperative Care; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Premedication; Recombinant Proteins; Ticlopidine | 2008 |
Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial.
Topics: Adult; Aged; Arteriovenous Shunt, Surgical; Clopidogrel; Double-Blind Method; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombosis; Ticlopidine; Vascular Patency | 2008 |
Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel-Thrombolys
Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Drug Therapy, Combination; Hemorrhage; Humans; Kaplan-Meier Estimate; Myocardial Infarction; Myocardial Ischemia; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Purinergic P2 Receptor Antagonists; Stents; Thiophenes; Ticlopidine | 2008 |
Effects of desmopressin on platelet membrane glycoproteins and platelet aggregation in volunteers on clopidogrel.
Topics: Adult; Antigens, CD; Blood Platelets; Clopidogrel; Deamino Arginine Vasopressin; Drug Synergism; Female; Hemostasis; Humans; Male; Membrane Glycoproteins; P-Selectin; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prospective Studies; Tetraspanin 30; Ticlopidine | 2008 |
Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease.
Topics: Aged; Antidotes; Aptamers, Nucleotide; Aspirin; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Combinations; Factor IXa; Female; Humans; Male; Middle Aged; Oligonucleotides; Ticlopidine; Treatment Outcome | 2008 |
Assessment of VerifyNow P2Y12 assay accuracy in evaluating clopidogrel-induced platelet inhibition.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Clopidogrel; Double-Blind Method; Female; Humans; Male; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prospective Studies; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sample Size; Ticlopidine | 2008 |
Prasugrel in the poststroke cohort of the TRITON Trial: the clear and present danger.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Hemorrhage; Humans; Ischemic Attack, Transient; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Secondary Prevention; Stents; Stroke; Thiophenes; Ticlopidine; Treatment Outcome | 2008 |
Tailoring treatment with tirofiban in patients showing resistance to aspirin and/or resistance to clopidogrel (3T/2R). Rationale for the study and protocol design.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Clopidogrel; Double-Blind Method; Drug Resistance; Europe; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Research Design; Ticlopidine; Tirofiban; Treatment Outcome; Troponin I; Troponin T; Tyrosine | 2008 |
A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cilostazol; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Tetrazoles; Ticlopidine; Treatment Outcome | 2008 |
Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects.
Topics: Adenosine Diphosphate; Adult; Aspirin; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Female; Hemorrhage; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2008 |
Effect of clopidogrel on adhesion molecules, hemostasis, and fibrinolysis in coronary heart disease.
Topics: Aged; Angina Pectoris; Aspirin; Cell Adhesion Molecules; Chronic Disease; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Fibrinolysis; Flow Cytometry; Hemostasis; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
The clopidogrel resistance can be attenuated with triple antiplatelet therapy in patients undergoing drug-eluting stents implantation.
Topics: Aged; Cardiovascular Surgical Procedures; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine | 2009 |
The role of clopidogrel and acetylsalicylic acid in the prevention of early-phase graft occlusion due to reactive thrombocytosis after coronary artery bypass operation.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombocytosis; Ticlopidine; Treatment Outcome | 2008 |
Long-term cost-effectiveness of clopidogrel in STEMI patients.
Topics: Aged; Aspirin; Clopidogrel; Cost-Benefit Analysis; Decision Trees; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Aspirin and clopidogrel treatment impair nitric oxide biosynthesis by platelets.
Topics: Adrenergic beta-Antagonists; Adult; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitric Oxide; Platelet Aggregation Inhibitors; Receptors, Adrenergic, beta; Signal Transduction; Ticlopidine | 2008 |
The antiplatelet effect of atorvastatin in patients with acute coronary syndrome depends on the hs-CRP level.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Atorvastatin; C-Reactive Protein; Clopidogrel; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2008 |
Smoking behaviour modulates pharmacokinetics of orally administered clopidogrel.
Topics: Administration, Oral; Adult; Area Under Curve; Body Weight; Clopidogrel; Drug Interactions; Half-Life; Humans; Male; Platelet Aggregation Inhibitors; Smoking; Ticlopidine | 2008 |
Aspirin and clopidogrel with or without phenprocoumon after drug eluting coronary stent placement in patients on chronic oral anticoagulation.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Coronary Vessels; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Phenprocoumon; Platelet Aggregation Inhibitors; Postoperative Period; Prospective Studies; Stroke; Ticlopidine; Treatment Outcome | 2008 |
Effect of 150-mg vs 300-mg loading doses of clopidogrel on platelet function in Japanese patients undergoing coronary stent placement.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Asian People; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Dose-Response Relationship, Drug; Female; Humans; Japan; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Comparison of increased aspirin dose versus combined aspirin plus clopidogrel therapy in patients with diabetes mellitus and coronary heart disease and impaired antiplatelet response to low-dose aspirin.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Failure | 2008 |
Comparison of higher clopidogrel loading and maintenance dose to standard dose on platelet function and outcomes after percutaneous coronary intervention using drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Single-Blind Method; Ticlopidine; Treatment Outcome | 2008 |
Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Secondary Prevention; Stroke; Thiophenes; Ticlopidine; Treatment Outcome | 2008 |
A randomised controlled trial of triple antiplatelet therapy (aspirin, clopidogrel and dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility.
Topics: Aged; Aspirin; Blood Pressure; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Drug Tolerance; Feasibility Studies; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Patient Selection; Platelet Aggregation Inhibitors; Pulse; Safety; Single-Blind Method; Stroke; Ticlopidine | 2008 |
Clinical evaluation of a novel occluder device (Occlutech) for percutaneous transcatheter closure of patent foramen ovale (PFO).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alloys; Aspirin; Balloon Occlusion; Cardiac Catheterization; Clopidogrel; Echocardiography, Transesophageal; Female; Femoral Vein; Fluoroscopy; Follow-Up Studies; Foramen Ovale, Patent; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Prostheses and Implants; Ticlopidine; Young Adult | 2008 |
Effect of PCI on quality of life in patients with stable coronary disease.
Topics: Adrenergic beta-Antagonists; Amlodipine; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Calcium Channel Blockers; Clopidogrel; Combined Modality Therapy; Coronary Disease; Cross-Over Studies; Drug Therapy, Combination; Female; Health Status; Humans; Isosorbide Dinitrate; Male; Metoprolol; Middle Aged; Patient Satisfaction; Platelet Aggregation Inhibitors; Quality of Life; Stents; Surveys and Questionnaires; Ticlopidine; Vasodilator Agents | 2008 |
Bivalirudin versus unfractionated heparin during percutaneous coronary intervention.
Topics: Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Heparin; Hirudins; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Premedication; Recombinant Proteins; Recurrence; Risk; Stents; Thrombosis; Ticlopidine | 2008 |
Antiplatelet therapy vs. anticoagulation in cervical artery dissection: rationale and design of the Cervical Artery Dissection in Stroke Study (CADISS).
Topics: Anticoagulants; Aortic Dissection; Aspirin; Clinical Protocols; Clopidogrel; Diagnostic Imaging; Dipyridamole; Drug Therapy, Combination; Endpoint Determination; Feasibility Studies; Heparin; Humans; Patient Selection; Platelet Aggregation Inhibitors; Prospective Studies; Quality Assurance, Health Care; Research Design; Sample Size; Single-Blind Method; Stroke; Ticlopidine; United Kingdom; Warfarin | 2007 |
Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cohort Studies; Coronary Artery Disease; Drug Resistance, Multiple; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Humans; Incidence; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Radiography; Risk Factors; Ticlopidine | 2008 |
Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease.
Topics: Aged; Aspirin; Cell Size; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Flow Cytometry; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Ticlopidine | 2008 |
Thienopyridine resistance among patients undergoing intracoronary stent implantation and treated with dual antiplatelet therapy: assessment of some modifying factors.
Topics: Adult; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Vessels; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Stents; Ticlopidine; Time Factors | 2008 |
Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Benzimidazoles; Benzoates; Brain Ischemia; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Double-Blind Method; Drug Therapy, Combination; Factor Analysis, Statistical; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk; Secondary Prevention; Stroke; Telmisartan; Ticlopidine; Vascular Diseases | 2008 |
[A clinical trial of using antiplatelet therapy to prevent restenosis following peripheral artery angioplasty and stenting].
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Arteriosclerosis Obliterans; Aspirin; Catheterization, Peripheral; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Period; Stents; Ticlopidine; Treatment Outcome | 2008 |
Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFE
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Aspirin; Benzimidazoles; Benzoates; Clopidogrel; Cognition; Dipyridamole; Disability Evaluation; Double-Blind Method; Drug Administration Schedule; Drug Delivery Systems; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; International Cooperation; Male; Mental Status Schedule; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Secondary Prevention; Severity of Illness Index; Stroke; Telmisartan; Ticlopidine | 2008 |
Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial I
Topics: Administration, Oral; Aged; Clopidogrel; Coronary Thrombosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2008 |
Use of and inhospital outcomes after early clopidogrel therapy in patients not undergoing an early invasive strategy for treatment of non-ST-segment elevation myocardial infarction: results from Can Rapid risk stratification of Unstable angina patients Su
Topics: Aged; Aged, 80 and over; Angina, Unstable; Clopidogrel; Electrocardiography; Female; Hemorrhage; Hospital Mortality; Hospitalization; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Ticlopidine; Treatment Outcome | 2008 |
Dose effect of clopidogrel reloading in patients already on 75-mg maintenance dose: the Reload with Clopidogrel Before Coronary Angioplasty in Subjects Treated Long Term with Dual Antiplatelet Therapy (RELOAD) study.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time | 2008 |
CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation.
Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Cardiac Surgical Procedures; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Risk Factors; Stents; Ticlopidine | 2008 |
Effect of ranitidine on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.
Topics: Adult; Chromatography, Liquid; Clopidogrel; Cross-Over Studies; Drug Interactions; Histamine H2 Antagonists; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ranitidine; Tandem Mass Spectrometry; Thiophenes; Ticlopidine | 2008 |
Effects of aspirin and clopidogrel in healthy men measured by platelet aggregation and PFA-100.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Epinephrine; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Ticlopidine | 2008 |
Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention results of the ARMYDA-PRO (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reac
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prognosis; Prospective Studies; ROC Curve; Ticlopidine; Treatment Outcome | 2008 |
Effects of aspirin dose on ischaemic events and bleeding after percutaneous coronary intervention: insights from the PCI-CURE study.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Death, Sudden, Cardiac; Double-Blind Method; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2009 |
Comparison of four tests to assess inhibition of platelet function by clopidogrel in stable coronary artery disease patients.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2008 |
Treatment of bifurcation lesions using dedicated bifurcation stents versus classic bare-metal stents. Randomized, controlled trial with 12-month angiographic follow up.
Topics: Adult; Aged; Anticoagulants; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Female; Fluoroscopy; Heparin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine | 2008 |
Safety and tolerability of 600 mg clopidogrel bolus in patients with acute ischemic stroke: preliminary experience.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Stroke; Ticlopidine | 2008 |
ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Comorbidity; Coronary Artery Disease; Drug Resistance; Female; Flow Cytometry; Humans; Incidence; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Ticlopidine | 2008 |
Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease.
Topics: Adult; Aspirin; Biomarkers; Blood Platelets; Cell Communication; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Monocytes; P-Selectin; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2008 |
Tirofiban optimizes platelet inhibition for immediate percutaneous coronary intervention in high-risk acute coronary syndromes.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Necrosis; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2008 |
Comparison of the impact of short (<1 year) and long-term (> or =1 year) clopidogrel use following percutaneous coronary intervention on mortality.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Benefit of oral anticoagulant over antiplatelet therapy in atrial fibrillation depends on the quality of international normalized ratio control achieved by centers and countries as measured by time in therapeutic range.
Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Brazil; Clopidogrel; Drug Therapy, Combination; Europe; Humans; International Normalized Ratio; Middle Aged; North America; Platelet Aggregation Inhibitors; Quality Control; South Africa; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Aprotinin for patients exposed to clopidogrel before off-pump coronary bypass.
Topics: Adult; Aged; Angina, Unstable; Aprotinin; Blood Transfusion; Chest Tubes; Clopidogrel; Coronary Artery Bypass, Off-Pump; Double-Blind Method; Drainage; Drug Administration Schedule; Female; Hemostatics; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Ticlopidine; Time Factors | 2008 |
Effect of increased aspirin dose after stenting in association with ClOpidogrel: the FIASCO randomized study.
Topics: Adenosine Diphosphate; Aged; Angina Pectoris; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Long-term clinical benefit of sirolimus-eluting stents in patients with in-stent restenosis results of the RIBS-II (Restenosis Intra-stent: Balloon angioplasty vs. elective sirolimus-eluting Stenting) study.
Topics: Aged; Angioplasty, Balloon, Coronary; Antibiotics, Antineoplastic; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Follow-Up Studies; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Sirolimus; Ticlopidine | 2008 |
Comparison of laboratory detection methods of aspirin resistance in coronary artery disease patients.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clinical Laboratory Techniques; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2010 |
Comparison of collagen versus adenosine diphosphate in detecting antiplatelet effect in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Collagen; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Ticlopidine; Treatment Outcome | 2009 |
Population pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in aspirin-treated patients with stable coronary artery disease.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Models, Biological; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2008 |
Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects.
Topics: Adolescent; Adult; Anticholesteremic Agents; Area Under Curve; Atorvastatin; Chromatography, Liquid; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Interactions; Epistaxis; Heptanoic Acids; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Molecular Structure; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyrroles; Tandem Mass Spectrometry; Thiophenes; Ticlopidine; United Kingdom; Young Adult | 2008 |
Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy.
Topics: Acute Coronary Syndrome; Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cause of Death; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Stroke; Ticlopidine; Treatment Outcome | 2008 |
Clopidogrel attenuates coated-platelet production in patients undergoing elective coronary catheterization.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Blood Platelets; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Crotalid Venoms; Female; Fibrinolytic Agents; Humans; Lectins, C-Type; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombin; Ticlopidine | 2008 |
A double-blind placebo-controlled investigation of the psychomotor profile of clopidogrel in healthy volunteers.
Topics: Administration, Oral; Choice Behavior; Clopidogrel; Double-Blind Method; Female; Flicker Fusion; Humans; Male; Platelet Aggregation Inhibitors; Psychomotor Performance; Reaction Time; Risk Assessment; Ticlopidine; Young Adult | 2008 |
The ELAPSE (Evaluation of Long-Term Clopidogrel Antiplatelet and Systemic Anti-Inflammatory Effects) study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Inflammation; Male; Middle Aged; Pilot Projects; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine | 2008 |
Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo.
Topics: Adult; Aged; Clopidogrel; Comorbidity; Coronary Artery Disease; Diabetes Complications; Double-Blind Method; Drug Resistance; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prevalence; Pyridines; Thiophenes; Ticlopidine; Treatment Failure; Treatment Outcome | 2008 |
Randomized trial comparing 600- with 300-mg loading dose of clopidogrel in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: results of the Platelet Responsiveness to Aspirin and Clopidogrel and Troponin
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardium; Necrosis; Platelet Aggregation Inhibitors; Ticlopidine; Troponin | 2009 |
Immediate versus deferred coronary angioplasty in non-ST-segment elevation acute coronary syndromes.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosis.
Topics: Acute Disease; Aged; Angina Pectoris; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Monitoring, Physiologic; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2009 |
[Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina].
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angina Pectoris; Atorvastatin; Clopidogrel; Drug Interactions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Pravastatin; Prospective Studies; Pyrroles; Ticlopidine | 2008 |
Clopidogrel resistance in Japanese patients scheduled for percutaneous coronary intervention.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Coronary Stenosis; Dose-Response Relationship, Drug; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Ischemia; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2009 |
Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study.
Topics: Adult; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Endpoint Determination; Female; Follow-Up Studies; Genotype; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proportional Hazards Models; Risk Factors; Secondary Prevention; Stents; Ticlopidine | 2009 |
Antiplatelet response to the 150-mg maintenance dose of clopidogrel in patients with insufficient platelet inhibition after clopidogrel loading for elective coronary stent placement.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2008 |
Functional variability of platelet response to clopidogrel correlates with P2Y(12) receptor occupancy.
Topics: Adenosine Diphosphate; Adolescent; Adult; Binding Sites; Blood Platelets; Clopidogrel; Double-Blind Method; Drug Resistance; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Young Adult | 2009 |
Thrombotic events in high risk patients are predicted by evaluating different pathways of platelet function.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Likelihood Functions; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine | 2008 |
Patients with peripheral arterial disease in the CHARISMA trial.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
A randomized, placebo-controlled study of the effects of naproxen, aspirin, celecoxib or clopidogrel on gastroduodenal mucosal healing.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clopidogrel; Drug Administration Schedule; Female; Gastric Mucosa; Humans; Male; Middle Aged; Naproxen; Peptic Ulcer; Pilot Projects; Pyrazoles; Sulfonamides; Ticlopidine; Young Adult | 2009 |
Bleeding risk associated with 1 year of dual antiplatelet therapy after percutaneous coronary intervention: Insights from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2009 |
Comparison of methods to evaluate clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reproducibility of Results; Sensitivity and Specificity; Stents; Ticlopidine | 2009 |
Iron-induced platelet aggregation measurement: a novel method to measure platelet function in stenting for ST segment elevation myocardial infarction.
Topics: Aged; Aspirin; Clopidogrel; Feasibility Studies; Female; Humans; Iron; Male; Middle Aged; Myocardial Infarction; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reproducibility of Results; Stainless Steel; Stents; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2009 |
Using a drug facts box to communicate drug benefits and harms: two randomized trials.
Topics: Adult; Advertising; Aged; Cardiovascular Diseases; Clopidogrel; Consumer Health Information; Female; Heartburn; Histamine H2 Antagonists; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Patient Education as Topic; Platelet Aggregation Inhibitors; Prescription Drugs; Proton Pump Inhibitors; Ticlopidine | 2009 |
Bivalirudin and clopidogrel with and without eptifibatide for elective stenting: effects on platelet function, thrombelastographic indexes, and their relation to periprocedural infarction results of the CLEAR PLATELETS-2 (Clopidogrel with Eptifibatide to
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Blood Coagulation; Blood Platelets; Clopidogrel; Collagen; Drug Therapy, Combination; Eptifibatide; Female; Hemorheology; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Recombinant Proteins; Stents; Thrombelastography; Ticlopidine | 2009 |
The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease.
Topics: Aged; Aspirin; Body Mass Index; Clopidogrel; Coronary Disease; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Thrombosis; Ticlopidine | 2009 |
Factors influencing clopidogrel efficacy in patients with stable coronary artery disease undergoing elective percutaneous coronary intervention: statin's advantage and the smoking "paradox".
Topics: Age Factors; Aged; Angioplasty, Balloon, Coronary; Aspirin; Body Mass Index; Cell Adhesion Molecules; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Heparin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Male; Microfilament Proteins; Phosphoproteins; Platelet Aggregation Inhibitors; Renal Insufficiency; Sex Factors; Smoking; Ticlopidine; Treatment Outcome | 2009 |
Assessment of P2Y(12) inhibition with the point-of-care device VerifyNow P2Y12 in patients treated with prasugrel or clopidogrel coadministered with aspirin.
Topics: Anticoagulants; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Male; Optical Rotation; Phosphorylation; Piperazines; Point-of-Care Systems; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2009 |
Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Endpoint Determination; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
Antiplatelet therapy in percutaneous coronary intervention: integration of prasugrel into clinical practice.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Severity of Illness Index; Survival Analysis; Thiophenes; Thromboembolism; Ticlopidine; Treatment Outcome | 2009 |
Temporal relation between Clopidogrel cessation and stent thrombosis after drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Single-dose randomized, open-label, 2-way crossover bioequivalence study of clopidogrel 75 mg tablet in healthy volunteers under fasting conditions.
Topics: Adult; Area Under Curve; Chromatography, High Pressure Liquid; Clopidogrel; Cross-Over Studies; Fasting; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Ticlopidine | 2009 |
A randomized controlled trial of a paclitaxel-eluting stent versus a similar bare-metal stent in saphenous vein graft lesions the SOS (Stenting of Saphenous Vein Grafts) trial.
Topics: Aged; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Saphenous Vein; Stents; Ticlopidine | 2009 |
The safety and efficacy of clopidogrel versus ticlopidine in Japanese stroke patients: combined results of two Phase III, multicenter, randomized clinical trials.
Topics: Aged; Brain Infarction; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Humans; Incidence; Japan; Liver; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Stroke; Ticlopidine; Treatment Outcome | 2009 |
Randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) trial.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Chronic Disease; Clopidogrel; Death; Double-Blind Method; Female; Fibrinolytic Agents; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Stroke; Stroke Volume; Ticlopidine; Warfarin | 2009 |
Heparin infusion after successful percutaneous coronary intervention: a prospective, randomized trial.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Female; Hemorrhage; Heparin; Humans; Incidence; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Time Factors | 2009 |
Considerable variability in platelet activity among patients with coronary artery disease in response to an increased maintenance dose of clopidogrel.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors | 2009 |
Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients W
Topics: Cilostazol; Clopidogrel; Coronary Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tetrazoles; Ticlopidine | 2009 |
Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Humans; Male; Middle Aged; Patient Satisfaction; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Retrospective Studies; Surveys and Questionnaires; Ticagrelor; Ticlopidine; Treatment Outcome | 2009 |
Rationale and design of a randomized, double-blind, placebo-controlled trial of 6 versus 12 months clopidogrel therapy after implantation of a drug-eluting stent: The Intracoronary Stenting and Antithrombotic Regimen: Safety And EFficacy of 6 Months Dual
Topics: Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Thrombosis; Dose-Response Relationship, Drug; Double-Blind Method; Drug-Eluting Stents; Follow-Up Studies; Humans; Incidence; Myocardial Revascularization; Platelet Aggregation Inhibitors; Postoperative Care; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Ethnic variation in adverse cardiovascular outcomes and bleeding complications in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) study.
Topics: Aged; Atherosclerosis; Cause of Death; Clopidogrel; Double-Blind Method; Ethnicity; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Risk Factors; Stroke; Ticlopidine; Time Factors; United States | 2009 |
Cilostazol in addition to aspirin and clopidogrel improves long-term outcomes after percutaneous coronary intervention in patients with acute coronary syndromes: a randomized, controlled study.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Radiography; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2009 |
Abciximab in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention after clopidogrel loading: a randomized double-blind trial.
Topics: Abciximab; Aged; Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Cardiac Catheterization; Child; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Immunoglobulin Fab Fragments; Infusions, Intravenous; Injections, Intravenous; Middle Aged; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Radionuclide Imaging; Radiopharmaceuticals; Stents; Technetium Tc 99m Sestamibi; Ticlopidine | 2009 |
Effect of clopidogrel added to aspirin in patients with atrial fibrillation.
Topics: Aged; Aspirin; Atrial Fibrillation; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Embolism; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Stroke; Ticlopidine; Vascular Diseases; Vitamin K | 2009 |
Frequency of CYP3A4, CYP3A5, CYP2C9, and CYP2C19 variant alleles in patients receiving clopidogrel that experience repeat acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Drug Resistance; Female; Gene Frequency; Genetic Variation; Genotype; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Ticlopidine; Treatment Failure | 2009 |
Interaction between cigarette smoking and clinical benefit of clopidogrel.
Topics: Aged; Clopidogrel; Electrocardiography; Female; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Smoking; Ticlopidine; Treatment Outcome | 2009 |
Efficacy of clopidrogel on reperfusion and high-sensitivity C-reactive protein in patients with acute myocardial infarction.
Topics: Aspirin; C-Reactive Protein; Clopidogrel; Coronary Circulation; Creatine Kinase, MB Form; Drug Therapy, Combination; Electrocardiography; Female; Fibrinolytic Agents; Heparin; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Tissue Plasminogen Activator; Treatment Outcome | 2009 |
Comparison of low vs moderate dose of atorvastatin in clopidogrel resistance after coronary stenting in Korean patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Anticholesteremic Agents; Atorvastatin; Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Heptanoic Acids; Humans; Korea; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Pyrroles; Single-Blind Method; Sirolimus; Ticlopidine; Time Factors | 2009 |
Evaluation of individualized clopidogrel therapy after drug-eluting stent implantation in patients with high residual platelet reactivity: design and rationale of the GRAVITAS trial.
Topics: Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Double-Blind Method; Drug-Eluting Stents; Electrocardiography; Graft Occlusion, Vascular; Humans; Male; Myocardial Ischemia; Myocardial Revascularization; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Care; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Genotype; Humans; Hydroxylation; Male; Omeprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Spectrophotometry, Ultraviolet; Sulfoxides; Ticlopidine; Young Adult | 2009 |
Insights into the interpretation of light transmission aggregometry for evaluation of platelet aggregation inhibition by clopidogrel.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine | 2009 |
Paclitaxel- versus sirolimus-eluting stents for unprotected left main coronary artery disease.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Confidence Intervals; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; Immunosuppressive Agents; Incidence; Male; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Risk; Sirolimus; Ticlopidine; Tubulin Modulators | 2009 |
Clinical outcomes of patients with diabetic nephropathy randomized to clopidogrel plus aspirin versus aspirin alone (a post hoc analysis of the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance [CHARISMA] tri
Topics: Aspirin; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Diabetic Nephropathies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Survival Analysis; Ticlopidine; Treatment Outcome | 2009 |
Genetic variation of CYP2C19 affects both pharmacokinetic and pharmacodynamic responses to clopidogrel but not prasugrel in aspirin-treated patients with coronary artery disease.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Genetic Variation; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
Bioequivalence and tolerability of two clopidogrel salt preparations, besylate and bisulfate: a randomized, open-label, crossover study in healthy Korean male subjects.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Area Under Curve; Chromatography, High Pressure Liquid; Clopidogrel; Cross-Over Studies; Humans; Korea; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Salts; Tandem Mass Spectrometry; Therapeutic Equivalency; Ticlopidine; Young Adult | 2009 |
Effect of the novel thienopyridine prasugrel compared with clopidogrel on spontaneous and procedural myocardial infarction in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardi
Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Biomarkers; Clopidogrel; Combined Modality Therapy; Creatine Kinase, MB Form; Death, Sudden, Cardiac; Double-Blind Method; Humans; Incidence; Kaplan-Meier Estimate; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Recurrence; Thiophenes; Ticlopidine; Time Factors; Troponin T | 2009 |
Assessment of platelet response to clopidogrel through measurement of ADP-induced Akt phosphorylation.
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Methods; Middle Aged; Phosphorylation; Proto-Oncogene Proteins c-akt; Ticlopidine | 2009 |
Outcomes following pre-operative clopidogrel administration in patients with acute coronary syndromes undergoing coronary artery bypass surgery: the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Care Units; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome; Triage | 2009 |
[Clopidogrel in the treatment of atrial fibrillation: benefit from addition to aspirin. The results of ACTIVE A trial].
Topics: Age Factors; Aged; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Follow-Up Studies; Humans; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Russia; Stroke; Survival Rate; Ticlopidine; Treatment Outcome | 2009 |
The antiplatelet effect of higher loading and maintenance dose regimens of clopidogrel: the PRINC (Plavix Response in Coronary Intervention) trial.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Female; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Verapamil | 2008 |
The pharmacogenetics and pharmacodynamics of clopidogrel response: an analysis from the PRINC (Plavix Response in Coronary Intervention) trial.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Gene Frequency; Genotype; Humans; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Thrombosis; Ticlopidine; Time Factors | 2008 |
Clopidogrel 150 mg/day to overcome low responsiveness in patients undergoing elective percutaneous coronary intervention: results from the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) randomized study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Europe; Female; Hemorrhage; Humans; Male; Microfilament Proteins; Middle Aged; Odds Ratio; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Assessment; Stents; Ticlopidine; Time Factors | 2008 |
Influence of timing of clopidogrel treatment on the efficacy and safety of bivalirudin in patients with non-ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention: an analysis of the ACUITY (Acute Catheterization and U
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Angiography; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemorrhage; Heparin; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Risk Assessment; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Troponin; Young Adult | 2008 |
Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: a prospective, randomized study.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Disease-Free Survival; Drug Resistance; Drug Therapy, Combination; Female; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Risk Assessment; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
The effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention: a BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) trial substudy.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Eptifibatide; Female; Heart Diseases; Hemorrhage; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Necrosis; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Safety and efficacy of biodegradable polymer-coated sirolimus-eluting stents in "real-world" practice: 18-month clinical and 9-month angiographic outcomes.
Topics: Aged; Angioplasty, Balloon, Coronary; Asia; Aspirin; Cardiovascular Agents; Clopidogrel; Coated Materials, Biocompatible; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymers; Product Surveillance, Postmarketing; Prospective Studies; Prosthesis Design; Registries; Risk Assessment; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial.
Topics: Acute Coronary Syndrome; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Factor Xa Inhibitors; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Ticlopidine; Young Adult | 2009 |
A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Effect of clopidogrel discontinuation at 1 year after drug eluting stent placement on soluble CD40L, P-selectin and C-reactive protein levels: DECADES (Discontinuation Effect of Clopidogrel After Drug Eluting Stent): a multicenter, open-label study.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; CD40 Ligand; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; P-Selectin; Ticlopidine; Time Factors | 2009 |
Comparing the antiplatelet effect of clopidogrel hydrogensulfate and clopidogrel besylate: a crossover study.
Topics: Adult; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Young Adult | 2009 |
The FDA prasugrel review: adjudication of myocardial infarction controversy.
Topics: Acute Coronary Syndrome; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Incidence; Male; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prognosis; Risk Assessment; Survival Analysis; Thiophenes; Ticlopidine; Treatment Outcome; United States; United States Food and Drug Administration | 2009 |
Static platelet adhesion, flow cytometry and serum TXB2 levels for monitoring platelet inhibiting treatment with ASA and clopidogrel in coronary artery disease: a randomised cross-over study.
Topics: Aged; Aspirin; Case-Control Studies; Clopidogrel; Coronary Disease; Cross-Over Studies; Female; Fibrinogen; Flow Cytometry; Health; Humans; Male; Middle Aged; P-Selectin; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Principal Component Analysis; Regression Analysis; Thromboxane B2; Ticlopidine | 2009 |
Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention: results from the double-blind, prospective, randomized Tailoring Treatment with Tirofiban in Patients Sho
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Coronary Thrombosis; Double-Blind Method; Drug Resistance; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Tirofiban; Tyrosine | 2009 |
High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial.
Topics: Adenosine Diphosphate; Aged; Antigens, Human Platelet; Clopidogrel; Coronary Artery Disease; Female; Humans; Integrin beta3; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine; Time Factors | 2009 |
[Difficulties in evaluating the efficacy of antiplatelet therapy in clinical practice].
Topics: Adult; Aspirin; Chronic Disease; Clopidogrel; Data Interpretation, Statistical; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Platelet aggregation inhibition in patients receiving statins either fully or partially metabolized by CYP3A4.
Topics: Aged; Anticholesteremic Agents; Atorvastatin; Clopidogrel; Cytochrome P-450 CYP3A; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Simvastatin; Thrombosis; Ticlopidine | 2008 |
Influence of statin treatment on platelet inhibition by clopidogrel - a randomized comparison of rosuvastatin, atorvastatin and simvastatin co-treatment.
Topics: Aged; Anticholesteremic Agents; Atorvastatin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Double-Blind Method; Drug Interactions; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Ticlopidine | 2009 |
Clopidogrel and aspirin versus clopidogrel alone on graft patency after coronary artery bypass grafting.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Elective Surgical Procedures; Female; Graft Occlusion, Vascular; Graft Rejection; Graft Survival; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Probability; Prognosis; Survival Rate; Ticlopidine; Treatment Outcome; Vascular Patency | 2009 |
Relation of genetic polymorphisms in the cytochrome P450 gene with clopidogrel resistance after drug-eluting stent implantation in Koreans.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Cilostazol; Clopidogrel; Confidence Intervals; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Humans; Korea; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Tetrazoles; Ticlopidine | 2009 |
[Effect of different duration of clopidogrel pretreatment on platelet activation in patients undergoing stenting].
Topics: Adult; Aged; Aged, 80 and over; Carotid Stenosis; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors | 2009 |
A randomised study comparing the antiplatelet and antiinflammatory effect of clopidogrel 150 mg/day versus 75 mg/day in patients with ST-segment elevation acute myocardial infarction and poor responsiveness to clopidogrel: results from the DOUBLE study.
Topics: Anterior Wall Myocardial Infarction; Anti-Inflammatory Agents; C-Reactive Protein; Cell Adhesion Molecules; Clopidogrel; Humans; Microfilament Proteins; Myocardial Infarction; Phosphoproteins; Platelet Aggregation; Ticlopidine | 2010 |
Postoperative blood loss in patients undergoing coronary artery bypass surgery after preoperative treatment with clopidogrel. A prospective randomised controlled study.
Topics: Aged; Blood Component Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Hemorrhage; Preoperative Care; Prospective Studies; Single-Blind Method; Ticlopidine | 2009 |
Thrombin formation and platelet activation at the site of vascular injury in patients with coronary artery disease treated with clopidogrel combined with aspirin.
Topics: Aspirin; Biomarkers; CD40 Ligand; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Therapy, Combination; Humans; Lacerations; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Punctures; Skin; Thrombin; Ticlopidine; Veins | 2009 |
Stent thrombosis up to 3 years after stenting for ST-segment elevation myocardial infarction versus for stable angina--comparison of the effects of drug-eluting versus bare-metal stents.
Topics: Angina Pectoris; Clopidogrel; Drug-Eluting Stents; Endpoint Determination; Humans; Myocardial Infarction; Pilot Projects; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Usefulness of the parent compound determination in bioequivalence evaluation of clopidogrel generic products.
Topics: Adult; Area Under Curve; Clopidogrel; Cross-Over Studies; Double-Blind Method; Half-Life; Humans; Male; Platelet Aggregation Inhibitors; Therapeutic Equivalency; Ticlopidine; Young Adult | 2009 |
Bioequivalence study of two different clopidogrel bisulfate film-coated tablets.
Topics: Adolescent; Adult; Area Under Curve; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Clopidogrel; Cross-Over Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Solubility; Spectrum Analysis; Sulfates; Tablets, Enteric-Coated; Therapeutic Equivalency; Ticlopidine; Young Adult | 2009 |
Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3.
Topics: Adenosine; Adenosine Diphosphate; Area Under Curve; Atherosclerosis; Clopidogrel; Dose-Response Relationship, Drug; Humans; Integrin beta3; Pharmacogenetics; Platelet Aggregation; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2009 |
Cross validation of the Multiple Electrode Aggregometry. A prospective trial in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Aspirin; Clopidogrel; Electrodes; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Time Factors; Young Adult | 2009 |
Relation between myocardial infarct size and ventricular tachyarrhythmia among patients with preserved left ventricular ejection fraction following fibrinolytic therapy for ST-segment elevation myocardial infarction.
Topics: Aged; Clopidogrel; Creatine Kinase, MB Form; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk Factors; Stroke Volume; Tachycardia, Ventricular; Thrombolytic Therapy; Ticlopidine; Ventricular Fibrillation | 2009 |
[Effects of upstream tirofiban versus downstream tirofiban on platelet aggregation and clinical outcomes in patients with high-risk acute coronary syndromes undergoing percutaneous coronary interventions].
Topics: Acute Coronary Syndrome; Adult; Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Risk Factors; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2009 |
The efficacy and safety of prasugrel with and without a glycoprotein IIb/IIIa inhibitor in patients with acute coronary syndromes undergoing percutaneous intervention: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Pla
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Stents; Stroke; Thiophenes; Ticlopidine | 2009 |
Marked reduction of early stent thrombosis with pre-hospital initiation of high-dose Tirofiban in ST-segment elevation myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Thrombosis; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Emergency Medical Services; Female; Fibrinolytic Agents; Hemorrhage; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Stents; Thrombolytic Therapy; Ticlopidine; Tirofiban; Tyrosine | 2009 |
Week-long high-maintenance dose clopidogrel regimen achieves better platelet aggregation inhibition than a standard loading dose before percutaneous coronary intervention: results of a double-blind, randomized clinical trial.
Topics: Analysis of Variance; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Female; Humans; Logistic Models; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2009 |
Effect of prasugrel versus clopidogrel on outcomes among patients with acute coronary syndrome undergoing percutaneous coronary intervention without stent implantation: a TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet inhibitio
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
Clopidogrel provides significantly greater inhibition of platelet activity than aspirin when combined with atorvastatin after coronary artery bypass grafting: a prospective randomized study.
Topics: Adenosine Diphosphate; Aged; Aspirin; Atorvastatin; Clopidogrel; Comorbidity; Coronary Artery Bypass; Coronary Disease; Drug Therapy, Combination; Female; Fibrinogen; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lipoproteins, LDL; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Complications; Prospective Studies; Pyrroles; Ticlopidine | 2010 |
Ticagrelor versus clopidogrel in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Double-Blind Method; Dyspnea; Electrocardiography; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Stroke; Ticagrelor; Ticlopidine | 2009 |
A comparison of anticoagulation with bivalirudin and provisional GPIIb/IIIa inhibition with unfractionated heparin and mandatory GPIIb/IIIa inhibition during percutaneous coronary intervention in relation to platelet activation and the inhibition of coagu
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Biomarkers; Blood Coagulation; CD40 Ligand; Clopidogrel; Drug Therapy, Combination; Female; Fibrinogen; Heparin; Hirudins; Humans; Lipoproteins; Male; Membrane Glycoproteins; Middle Aged; Monocytes; Peptide Fragments; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prothrombin; Recombinant Proteins; Thromboplastin; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Effect of the thromboxane prostaglandin receptor antagonist terutroban on arterial thrombogenesis after repeated administration in patients treated for the prevention of ischemic stroke.
Topics: Aged; Aged, 80 and over; Aspirin; Biomarkers; Brain Ischemia; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Intracranial Thrombosis; Male; Middle Aged; Naphthalenes; Platelet Aggregation; Platelet Aggregation Inhibitors; Propionates; Receptors, Thromboxane; Stroke; Ticlopidine | 2009 |
Long term efficacy of abciximab bolus-only compared to abciximab bolus and infusion after transradial coronary stenting.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Infusions, Parenteral; Injections; Length of Stay; Logistic Models; Male; Middle Aged; Myocardial Infarction; Patient Discharge; Platelet Aggregation Inhibitors; Proportional Hazards Models; Radial Artery; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Stents; Ticlopidine | 2009 |
Gastrointestinal bleeding in patients with acute coronary syndromes: incidence, predictors, and clinical implications: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Artery Bypass; Female; Gastrointestinal Hemorrhage; Heparin; Hirudins; Humans; Incidence; Ischemia; Length of Stay; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Risk Assessment; Sex Factors; Stents; Thrombosis; Ticlopidine | 2009 |
Timing of clopidogrel loading before percutaneous coronary intervention in clopidogrel-naive patients with stable or unstable angina: a comparison of two strategies.
Topics: Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; C-Reactive Protein; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Nephelometry and Turbidimetry; P-Selectin; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Randomized controlled trial of aspirin and clopidogrel versus aspirin and placebo on markers of smooth muscle proliferation before and after peripheral angioplasty.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Aspirin; Biomarkers; Blotting, Western; Cell Proliferation; Cells, Cultured; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; E-Selectin; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Graft Occlusion, Vascular; Humans; Intercellular Adhesion Molecule-1; Male; Middle Aged; Mitogen-Activated Protein Kinase 3; Multivariate Analysis; Muscle, Smooth, Vascular; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; Probability; Radiography; Reference Values; Statistics, Nonparametric; Ticlopidine | 2009 |
Role of clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: results from the HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trial.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon; Anticoagulants; Clopidogrel; Confidence Intervals; Female; Hirudins; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Proportional Hazards Models; Recombinant Proteins; Ticlopidine; Treatment Outcome | 2009 |
Effect of high bolus dose tirofiban on the inflammatory response following percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Biomarkers; C-Reactive Protein; CD40 Antigens; Clopidogrel; Creatine Kinase, MB Form; Female; Humans; Inflammation; Interleukin-6; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors; Tirofiban; Tyrosine | 2010 |
The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients.
Topics: Adenosine Diphosphate; Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Blood Coagulation; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Collagen; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Therapy, Combination; Female; Gene Frequency; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Phenotype; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Purinergic P2 Receptor Antagonists; Quinazolinones; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Sulfonamides; Thrombelastography; Ticlopidine | 2010 |
Impact of final activated clotting time after transradial coronary stenting with maximal antiplatelet therapy.
Topics: Abciximab; Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; Creatine Kinase, MB Form; Female; Follow-Up Studies; Hematoma; Hemorrhage; Heparin; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Count; Premedication; Retreatment; Sex Factors; Stents; Ticlopidine; Troponin T; Whole Blood Coagulation Time | 2009 |
A comparison of clopidogrel responsiveness in patients with versus without chronic renal failure.
Topics: Analysis of Variance; Clopidogrel; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Single-Blind Method; Ticlopidine | 2009 |
Design and rationale of the WOEST trial: What is the Optimal antiplatElet and anticoagulant therapy in patients with oral anticoagulation and coronary StenTing (WOEST).
Topics: Administration, Oral; Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2009 |
Comparison of the efficacy and safety of zotarolimus-, sirolimus-, and paclitaxel-eluting stents in patients with ST-elevation myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Paclitaxel; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Sirolimus; Ticlopidine | 2009 |
Platelet inhibition with cangrelor in patients undergoing PCI.
Topics: Acute Coronary Syndrome; Adenosine Monophosphate; Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Double-Blind Method; Female; Hemorrhage; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retreatment; Ticlopidine; Treatment Failure | 2009 |
Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study.
Topics: Adenosine; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Treatment Outcome | 2009 |
Smoking, clopidogrel, and mortality in patients with established cardiovascular disease.
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Prospective Studies; Smoking; Ticlopidine | 2009 |
Semi-jailing technique for coil embolization of complex, wide-necked intracranial aneurysms.
Topics: Adult; Aged; Aspirin; Blood Vessel Prosthesis; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Microsurgery; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Design; Stents; Ticlopidine; Treatment Outcome | 2009 |
Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Female; Humans; Leukocytes; Male; Obesity; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2010 |
Pantoprazole may enhance antiplatelet effect of enteric-coated aspirin in patients with acute coronary syndrome.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Coronary Angiography; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Stents; Tablets, Enteric-Coated; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Bioequivalence of two oral formulations of clopidogrel tablets in healthy male volunteers.
Topics: Administration, Oral; Adult; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Tablets; Therapeutic Equivalency; Ticlopidine | 2009 |
Reasonable duration of Clopidogrel use after drug-eluting stent implantation in Korean patients.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Korea; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Clopidogrel; Down-Regulation; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thromboxane A2; Thromboxane B2; Ticlopidine; Young Adult | 2010 |
Primary percutaneous coronary angioplasty with and without eptifibatide in ST-segment elevation myocardial infarction: a safety and efficacy study of integrilin-facilitated versus primary percutaneous coronary intervention in ST-segment elevation myocardi
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Drug Administration Schedule; Drug Therapy, Combination; Eptifibatide; Female; Hemorrhage; Heparin; Humans; Infusions, Intravenous; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Ontario; Peptides; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Risk Assessment; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Effect of an increased clopidogrel maintenance dose or lansoprazole co-administration on the antiplatelet response to clopidogrel in CYP2C19-genotyped healthy subjects.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Heterozygote; Homozygote; Humans; Lansoprazole; Male; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine; Young Adult | 2010 |
5-year clinical outcomes in the ICTUS (Invasive versus Conservative Treatment in Unstable coronary Syndromes) trial a randomized comparison of an early invasive versus selective invasive management in patients with non-ST-segment elevation acute coronary
Topics: Abciximab; Acute Coronary Syndrome; Adolescent; Adult; Aged; Aged, 80 and over; Angina, Unstable; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Angiography; Electrocardiography; Enoxaparin; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Revascularization; Netherlands; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2010 |
Urgent surgery in patients with a recently implanted coronary drug-eluting stent: a phase II study of 'bridging' antiplatelet therapy with tirofiban during temporary withdrawal of clopidogrel.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Administration Schedule; Drug-Eluting Stents; Emergencies; Female; Hemostasis, Surgical; Humans; Male; Middle Aged; Perioperative Care; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Substance Withdrawal Syndrome; Ticlopidine; Tirofiban; Tyrosine | 2010 |
Assessment of clopidogrel non-response by the PFA-100 system using the new test cartridge INNOVANCE PFA P2Y.
Topics: Aged; Aged, 80 and over; Arterial Occlusive Diseases; Aspirin; Blood Platelets; Catheterization, Peripheral; Clopidogrel; Diagnostic Techniques, Cardiovascular; Female; Fibrinolytic Agents; Hemostasis; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Prognosis; Reagent Kits, Diagnostic; Ticlopidine; Treatment Failure | 2010 |
Development and validation of high-throughput liquid chromatography-tandem mass spectrometric method for simultaneous quantification of clopidogrel and its metabolite in human plasma.
Topics: Calibration; Chromatography, Liquid; Clopidogrel; Drug Stability; Humans; Ions; Male; Online Systems; Platelet Aggregation Inhibitors; Reproducibility of Results; Robotics; Tandem Mass Spectrometry; Ticlopidine; Time Factors | 2010 |
Clopidogrel response status assessed with Multiplate point-of-care analysis and the incidence and timing of stent thrombosis over six months following coronary stenting.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Blood Coagulation Tests; Clopidogrel; Drug Monitoring; Drug Resistance; Drug-Eluting Stents; Female; Germany; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine; Time Factors; Treatment Failure | 2010 |
A new oral antiplatelet agent with potent antithrombotic properties: comparison of DZ-697b with clopidogrel a randomised phase I study.
Topics: Administration, Oral; Adult; Bleeding Time; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2010 |
Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Paris; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Low postoperative dose of aprotinin reduces bleeding and is safe in patients receiving clopidogrel before coronary artery bypass surgery. A prospective randomized study.
Topics: Adult; Aged; Aged, 80 and over; Aprotinin; Blood Transfusion; Cerebrovascular Disorders; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Female; Hemostatics; Humans; Intraoperative Care; Kidney Diseases; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Hemorrhage; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
PROCLAIM: pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirin.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Atherosclerosis; Biomarkers; C-Reactive Protein; CD40 Ligand; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Inflammation Mediators; Least-Squares Analysis; Male; Metabolic Syndrome; Middle Aged; Natriuretic Peptide, Brain; P-Selectin; Peptide Fragments; Pilot Projects; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; United States; Young Adult | 2009 |
Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2010 |
[Comparison on long-term effects of atorvastatin or pravastatin combined with clopidogrel for patients undergoing coronary stenting: a randomized controlled trial].
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Atorvastatin; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Heptanoic Acids; Humans; Male; Middle Aged; Pravastatin; Pyrroles; Ticlopidine; Time; Treatment Outcome; Young Adult | 2009 |
Extent of ST-segment resolution after fibrinolysis adds improved risk stratification to clinical risk score for ST-segment elevation myocardial infarction.
Topics: Adult; Aged; Clopidogrel; Confidence Intervals; Coronary Angiography; Coronary Circulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Fibrinolysis; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Probability; Risk Assessment; Severity of Illness Index; Survival Analysis; Thrombolytic Therapy; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2010 |
Comparison of Triple antiplatelet therapy and dual antiplatelet therapy in patients at high risk of restenosis after drug-eluting stent implantation (from the DECLARE-DIABETES and -LONG Trials).
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Restenosis; Diabetes Complications; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Treatment Outcome | 2010 |
High maintenance dosage of clopidogrel is associated with a reduced risk of stent thrombosis in clopidogrel-resistant patients.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Resistance; Drug-Eluting Stents; Female; Follow-Up Studies; France; Hemorrhage; Hospitals, University; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Regression Analysis; Risk; Stents; Ticlopidine; Treatment Outcome | 2010 |
Reducing cardiac ischemic events in patients with ACS: prasugrel versus clopidogrel. Commentary.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Confidence Intervals; Double-Blind Method; Drug Therapy, Combination; Humans; Myocardial Ischemia; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticlopidine | 2010 |
Evaluation of platelet inhibition by tirofiban in patients stratified according to aspirin and clopidogrel responsiveness: the 3T/2R (Tailoring treatment with tirofiban in patients showing resistance to aspirin and/or resistance to clopidogrel).
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cohort Studies; Drug Resistance; Humans; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Tirofiban; Tyrosine | 2010 |
Adding cilostazol to dual antiplatelet therapy achieves greater platelet inhibition than high maintenance dose clopidogrel in patients with acute myocardial infarction: Results of the adjunctive cilostazol versus high maintenance dose clopidogrel in patie
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Blood Vessel Prosthesis Implantation; Cells, Cultured; Chemotherapy, Adjuvant; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tetrazoles; Ticlopidine | 2010 |
Cardioprotective effects of ischemic postconditioning in patients treated with primary percutaneous coronary intervention, evaluated by magnetic resonance.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiotonic Agents; Chemotherapy, Adjuvant; Clopidogrel; Disease Progression; Electrocardiography; Female; Heart Function Tests; Heparin; Humans; Magnetic Resonance Angiography; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Survival Analysis; Ticlopidine | 2010 |
Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Double-Blind Method; Female; Heparin; Humans; Japan; Lactones; Male; Middle Aged; Placebos; Pyridines; Receptor, PAR-1; Ticlopidine | 2010 |
Effect of cilostazol on platelet aggregation in patients with non-ST elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Aspirin; Cilostazol; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine | 2010 |
Effects of omeprazole on the antiplatelet activity of clopidogrel.
Topics: Adult; Anti-Ulcer Agents; Blood Platelets; Clopidogrel; Cross-Over Studies; Drug Interactions; Female; Humans; Male; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
A double-blind, randomized study on prevention and existence of a rebound phenomenon of platelets after cessation of clopidogrel treatment.
Topics: Aged; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
Warfarin after anterior myocardial infarction in current era of dual antiplatelet therapy: a randomized feasibility trial.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Embolism; Feasibility Studies; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Ontario; Platelet Aggregation Inhibitors; Recurrence; Stroke; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography; Ventricular Dysfunction, Left; Warfarin | 2010 |
In-hospital outcomes of contemporary percutaneous coronary intervention in patients with chronic total occlusion insights from the J-CTO Registry (Multicenter CTO Registry in Japan).
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Female; Humans; Inpatients; Japan; Length of Stay; Male; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Bioequivalence of two tablet formulations of clopidogrel in healthy Argentinian volunteers: a single-dose, randomized-sequence, open-label crossover study.
Topics: Administration, Oral; Adult; Area Under Curve; Argentina; Chromatography, High Pressure Liquid; Clopidogrel; Cross-Over Studies; Drugs, Generic; Female; Humans; Male; Platelet Aggregation Inhibitors; Reference Values; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Ticlopidine; Young Adult | 2010 |
Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Predictive Value of Tests; Prospective Studies; Stents; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Modified thromboelastography evaluation of platelet dysfunction in patients undergoing coronary artery surgery.
Topics: Aged; Aspirin; Blood Platelet Disorders; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Prognosis; Thrombelastography; Ticlopidine | 2010 |
Effect of combined aspirin and extended-release dipyridamole versus clopidogrel on functional outcome and recurrence in acute, mild ischemic stroke: PRoFESS subgroup analysis.
Topics: Aged; Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Female; Fibrinolytic Agents; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Recovery of Function; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2010 |
Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Angioplasty, Balloon, Laser-Assisted; Antibodies, Monoclonal; Arm; Aspirin; Clopidogrel; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Hospitalization; Humans; Immunoglobulin Fab Fragments; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Platelet Aggregation Inhibitors; Prospective Studies; Radiopharmaceuticals; Technetium Tc 99m Sestamibi; Ticlopidine; Time Factors; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Troponin T | 2010 |
Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study.
Topics: Adenosine; Aged; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2010 |
Pharmacodynamics and pharmacokinetics of single doses of prasugrel 30 mg and clopidogrel 300 mg in healthy Chinese and white volunteers: an open-label trial.
Topics: Administration, Oral; Adult; Asian People; Blood Platelets; Cell Adhesion Molecules; China; Clopidogrel; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Singapore; Thiophenes; Ticlopidine; White People; Young Adult | 2010 |
Duration of dual antiplatelet therapy after implantation of drug-eluting stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retreatment; Stroke; Thrombosis; Ticlopidine | 2010 |
Efficacy of high-dose atorvastatin loading before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: the STATIN STEMI trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Atorvastatin; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Coronary Circulation; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kaplan-Meier Estimate; Korea; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Pyrroles; Recurrence; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial.
Topics: Adult; Aged; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Female; Hong Kong; Humans; Intention to Treat Analysis; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Regression Analysis; Statistics, Nonparametric; Stroke; Ticlopidine; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2010 |
Pharmacokinetics and the antiplatelet effect of a new clopidogrel formulation, clopidogrel besylate, in healthy subjects.
Topics: Adult; Area Under Curve; Chemistry, Pharmaceutical; Clopidogrel; Cross-Over Studies; Double-Blind Method; Half-Life; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2010 |
Systemic low-dose aspirin and clopidogrel independently attenuate reflex cutaneous vasodilation in middle-aged humans.
Topics: Aspirin; Blood Flow Velocity; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Reflex; Skin; Skin Physiological Phenomena; Ticlopidine; Vasodilation | 2010 |
Clopidogrel reloading in patients undergoing percutaneous coronary intervention on chronic clopidogrel therapy: results of the ARMYDA-4 RELOAD (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) randomized trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; Clopidogrel; Coronary Aneurysm; Double-Blind Method; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2010 |
Impact of early abciximab administration on myocardial reperfusion in patients with ST-segment elevation myocardial infarction pretreated with 600 mg of clopidogrel before percutaneous coronary intervention.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Vascular Patency | 2010 |
Contemporary incidence and predictors of major adverse cardiac events after saphenous vein graft intervention with embolic protection (an AMEthyst trial substudy).
Topics: Aged; Clopidogrel; Coronary Angiography; Coronary Stenosis; Drug-Eluting Stents; Embolism; Female; Humans; Incidence; Male; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prognosis; Risk Factors; Saphenous Vein; Survival Rate; Ticlopidine; United States | 2010 |
Changes in inflammatory biomarkers in patients treated with ticagrelor or clopidogrel.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Biomarkers; C-Reactive Protein; CD40 Ligand; Clopidogrel; Double-Blind Method; Female; Humans; Interleukin-6; Male; Middle Aged; Peroxidase; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticagrelor; Ticlopidine | 2010 |
Effects of polyunsaturated omega-3 fatty acids on responsiveness to dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: the OMEGA-PCI (OMEGA-3 fatty acids after pci to modify responsiveness to dual antiplatelet therapy) st
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Blood Proteins; Cell Adhesion Molecules; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Fatty Acids, Omega-3; Female; Follow-Up Studies; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prognosis; Prospective Studies; Ticlopidine; Treatment Outcome | 2010 |
Pantoprazole does not influence the antiplatelet effect of clopidogrel-a whole blood aggregometry study after coronary stenting.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Esomeprazole; Female; Humans; Male; Middle Aged; Multivariate Analysis; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Regression Analysis; Stents; Ticlopidine | 2010 |
Ticagrelor, a new antiplatelet agent, for prevention of ischemic events in patients with coronary artery disease.
Topics: Adenosine; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Ischemia; Male; Platelet Aggregation Inhibitors; Proportional Hazards Models; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Smoking at least 10 cigarettes per day increases platelet inhibition by clopidogrel in patients with ST-segment-elevation myocardial infarction.
Topics: Adult; Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Smoking; Ticlopidine | 2010 |
Prasugrel vs. clopidogrel for cytochrome P450 2C19-genotyped subgroups: integration of the TRITON-TIMI 38 trial data.
Topics: Aged; Angina, Unstable; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Genetic Variation; Genotype; Humans; Middle Aged; Myocardial Infarction; Pharmacogenetics; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk; Thiophenes; Ticlopidine; Treatment Outcome | 2010 |
Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Confidence Intervals; Coronary Stenosis; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Eluting Stents; Elective Surgical Procedures; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Predictive Value of Tests; Probability; Prospective Studies; Prosthesis Failure; Risk Assessment; Stents; Survival Analysis; Ticlopidine | 2010 |
Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease: results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHAR
Topics: Aged; Aspirin; Clopidogrel; Disease Management; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Risk Factors; Survival Rate; Thrombosis; Ticlopidine; Vascular Diseases | 2010 |
Impact of chronic antiplatelet therapy before hospitalization on ischemic and bleeding events in invasively managed patients with acute coronary syndromes: the ACUITY trial.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Aspirin; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Europe; Female; Hemorrhage; Hospitalization; Humans; Incidence; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; New Zealand; Odds Ratio; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; United States | 2011 |
The impact of generic clopidogrel bisulfate on platelet inhibition in patients with coronary artery stents: results of the ACCEL-GENERIC study.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Drug-Eluting Stents; Drugs, Generic; Female; Follow-Up Studies; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2010 |
Randomized controlled trial of dual antiplatelet therapy in patients undergoing surgery for critical limb ischemia.
Topics: Aged; Amputation, Surgical; Aspirin; Clopidogrel; Double-Blind Method; Female; Flow Cytometry; Hemorrhage; Humans; Ischemia; Leg; Male; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Troponin | 2010 |
Early dynamic risk stratification with baseline troponin levels and 90-minute ST-segment resolution to predict 30-day cardiovascular mortality in ST-segment elevation myocardial infarction: analysis from CLopidogrel as Adjunctive ReperfusIon TherapY (CLAR
Topics: Clopidogrel; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Humans; Immunoassay; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Risk Factors; Survival Rate; Thrombolytic Therapy; Ticlopidine; Time Factors; Treatment Outcome; Troponin | 2010 |
One-year clinical outcomes with abciximab in acute myocardial infarction: results of the BRAVE-3 randomized trial.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Stents; Stroke; Ticlopidine; Treatment Outcome | 2010 |
Randomized, double-blind comparison of effects of abiciximab bolus only vs. on-label regimen on ex vivo inhibition of platelet aggregation in responders to clopidogrel undergoing coronary stenting.
Topics: Abciximab; Aged; Angiography; Antibodies, Monoclonal; Blood Platelets; Clopidogrel; Double-Blind Method; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine; Time Factors | 2010 |
Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients: a prespecified substudy of the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Incidence; Intention to Treat Analysis; Kaplan-Meier Estimate; Male; Platelet Aggregation Inhibitors; Risk Factors; Risk Reduction Behavior; Severity of Illness Index; Stroke; Ticlopidine; Treatment Outcome | 2010 |
Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage
Topics: Administration, Oral; Aged; Angina, Unstable; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Follow-Up Studies; Global Health; Humans; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Survival Rate; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
The Strategic Reperfusion Early After Myocardial Infarction (STREAM) study.
Topics: Aged; Aspirin; Cardiac Catheterization; Cause of Death; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Enoxaparin; Fibrinolytic Agents; Follow-Up Studies; Humans; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Prospective Studies; Survival Rate; Thrombolytic Therapy; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y(12)-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous
Topics: Administration, Oral; Adolescent; Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Tolerance; Female; Follow-Up Studies; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Quinazolinones; Receptors, Purinergic P2Y12; Sulfonamides; Ticlopidine; Time Factors; Treatment Outcome; Troponin; Young Adult | 2010 |
Clopidogrel pretreatment in ST-elevation myocardial infarction patients transferred for percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Restenosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Minnesota; Myocardial Infarction; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Survival Rate; Ticlopidine; Treatment Outcome | 2010 |
Prehospital high-dose tirofiban in patients undergoing primary percutaneous intervention. The AGIR-2 study.
Topics: Ambulances; Angioplasty, Balloon, Coronary; Biomarkers; Clopidogrel; Coronary Angiography; Coronary Circulation; Creatine Kinase; Drug Administration Schedule; Drug Therapy, Combination; Emergency Medical Services; Female; France; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Troponin I; Tyrosine | 2010 |
Incidence of dyspnea and assessment of cardiac and pulmonary function in patients with stable coronary artery disease receiving ticagrelor, clopidogrel, or placebo in the ONSET/OFFSET study.
Topics: Adenosine; Aged; Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Dyspnea; Female; Heart; Humans; Lung; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticagrelor; Ticlopidine | 2010 |
Prasugrel versus clopidogrel in Asian patients with acute coronary syndromes: design and rationale of a multi-dose, pharmacodynamic, phase 3 clinical trial.
Topics: Acute Coronary Syndrome; Adolescent; Adult; Aged; Algorithms; Asian People; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Research Design; Thiophenes; Ticlopidine; Young Adult | 2010 |
Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers.
Topics: Adenosine; Adult; Clopidogrel; Dose-Response Relationship, Drug; Fasting; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine; Treatment Outcome; Young Adult | 2010 |
Lack of evidence for pleiotropic effects of clopidogrel on endothelial function and inflammation in patients with stable coronary artery disease: results of the double-blind, randomized CASSANDRA study.
Topics: Clopidogrel; Comorbidity; Coronary Artery Disease; Double-Blind Method; Endothelium, Vascular; Evidence-Based Medicine; Female; Germany; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome; Vasculitis | 2011 |
[Impact of application time of aspirin and clopidogrel on platelet aggregation in patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Adult; Aged; Aspirin; Circadian Rhythm; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Time Factors | 2010 |
[Glycoprotein IIb-IIIa antagonist Monafram in primary angioplasty of patients with acute coronary syndrome without st segment elevation].
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Electrocardiography; Female; Fibrinolytic Agents; Hemorrhage; Heparin; Humans; Injections, Intravenous; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Secondary Prevention; Thrombocytopenia; Ticlopidine; Treatment Outcome | 2010 |
A randomised determination of the Effect of Fluvastatin and Atorvastatin on top of dual antiplatelet treatment on platelet aggregation after implantation of coronary drug-eluting stents. The EFA-Trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Atorvastatin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Prosthesis Design; Pyrroles; Switzerland; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Differential sensitivity and kinetics of response of different ex vivo tests monitoring functional variability of platelet response to clopidogrel.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Flow Cytometry; Humans; Kinetics; Male; Microfilament Proteins; Nephelometry and Turbidimetry; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Thionucleotides; Thrombelastography; Ticlopidine; Young Adult | 2010 |
Intra-individual variability in clopidogrel responsiveness in coronary artery disease patients under long term therapy.
Topics: Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Individuality; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2010 |
Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial.
Topics: Aged; Amputation, Surgical; Aspirin; Australia; Blood Vessel Prosthesis Implantation; Chi-Square Distribution; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Europe; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Kaplan-Meier Estimate; Lower Extremity; Male; Middle Aged; Peripheral Vascular Diseases; Placebo Effect; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Reoperation; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency; Veins | 2010 |
Mortality predictors and effects of antithrombotic therapies in atrial fibrillation: insights from ACTIVE-W.
Topics: Aspirin; Atrial Fibrillation; Biphenyl Compounds; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Irbesartan; Kaplan-Meier Estimate; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome; Vitamin K | 2010 |
Effectiveness of in-laboratory high-dose clopidogrel loading versus routine pre-load in patients undergoing percutaneous coronary intervention: results of the ARMYDA-5 PRELOAD (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) ra
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
Is gastroduodenal biopsy safe in patients receiving aspirin and clopidogrel?: a prospective, randomized study involving 630 biopsies.
Topics: Adult; Aspirin; Biopsy; Clopidogrel; Duodenum; Endoscopy, Digestive System; Female; Gastrointestinal Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Pyloric Antrum; Risk Factors; Single-Blind Method; Ticlopidine | 2011 |
Lack of clopidogrel-statin interaction in patients undergoing coronary stent implantation.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Atorvastatin; Clopidogrel; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Pyrroles; Simvastatin; Ticlopidine | 2010 |
Cilostazol augments the inhibition of platelet aggregation in clopidogrel low-responders.
Topics: Blood Platelets; Cilostazol; Clopidogrel; Drug Synergism; Drug-Eluting Stents; Humans; Platelet Aggregation; Platelet Function Tests; Prospective Studies; Receptors, Purinergic P2Y12; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Randomised controlled trial evaluating the role of tirofiban in high-risk non-ST elevation acute coronary syndromes: an East Indian perspective.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Emergency Service, Hospital; Enoxaparin; Female; Follow-Up Studies; Humans; India; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Reference Values; Severity of Illness Index; Survival Rate; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2010 |
Background, incidence, and predictors of antiplatelet therapy discontinuation during the first year after drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug-Eluting Stents; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Medication Adherence; Middle Aged; Multivariate Analysis; Patient Readmission; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Renal Insufficiency; Self Medication; Thrombosis; Ticlopidine | 2010 |
Study design and rationale of 'Influence of Cilostazol-based triple anti-platelet therapy on ischemic complication after drug-eluting stent implantation (CILON-T)' study: A multicenter randomized trial evaluating the efficacy of Cilostazol on ischemic vas
Topics: Angioplasty, Balloon, Coronary; Aspirin; Brain Ischemia; Cilostazol; Clinical Protocols; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prospective Studies; Prosthesis Design; Republic of Korea; Research Design; Stroke; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
The Platelet Activity After Clopidogrel Termination (PACT) study.
Topics: Adenosine Diphosphate; Adult; Aged; Blood Platelets; CD40 Ligand; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Withholding Treatment | 2010 |
Comparison between the effect of omeprazole and rabeprazole on the antiplatelet action of clopidogrel.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabeprazole; Ticlopidine; Treatment Outcome | 2010 |
Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Blood Glucose; Clopidogrel; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glycated Hemoglobin; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
ISAR-REACT 3A: a study of reduced dose of unfractionated heparin in biomarker negative patients undergoing percutaneous coronary intervention.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Biomarkers; Clopidogrel; Death, Sudden, Cardiac; Drug Therapy, Combination; Female; Follow-Up Studies; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Ticlopidine; Treatment Outcome | 2010 |
Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: results from the Platelet Inhibition and Patient Outcomes (PLATO) trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Cardiovascular Diseases; Chronic Disease; Clopidogrel; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Kidney Diseases; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2010 |
Dose comparisons of clopidogrel and aspirin in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Coronary Artery Bypass; Double-Blind Method; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Research Design; Stroke; Ticlopidine | 2010 |
Cytochrome 2C19 polymorphism and response to adjunctive cilostazol versus high maintenance-dose clopidogrel in patients undergoing percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Chemotherapy, Adjuvant; Cilostazol; Clopidogrel; Codon, Nonsense; Cytochrome P-450 CYP2C19; DNA Mutational Analysis; Humans; Ischemia; Platelet Aggregation; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Tetrazoles; Ticlopidine | 2010 |
Comparison of rosuvastatin and atorvastatin on clopidogrel response and lipidic and inflammatory parameters after coronary stenting for acute coronary syndrome: the prospective, randomized OSCAR study (optimal statin therapy with clopidogrel after coronar
Topics: Acute Coronary Syndrome; Anticholesteremic Agents; Atorvastatin; Clopidogrel; Combined Modality Therapy; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fluorobenzenes; Heptanoic Acids; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Stents; Sulfonamides; Ticlopidine | 2010 |
Rationale and design of a randomized, double-blind trial comparing the effects of a 3-month clopidogrel-aspirin regimen versus aspirin alone for the treatment of high-risk patients with acute nondisabling cerebrovascular event.
Topics: Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Humans; Intention to Treat Analysis; Ischemic Attack, Transient; Outcome Assessment, Health Care; Patient Selection; Platelet Aggregation Inhibitors; Research Design; Risk Assessment; Sample Size; Stroke; Ticlopidine | 2010 |
The efficacy and safety of clopidogrel in vascular surgery patients with immediate postoperative asymptomatic troponin T release for the prevention of late cardiac events: Rationale and design of the Dutch Echocardiographic Cardiac Risk Evaluation Applyin
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Echocardiography, Stress; Humans; Myocardial Infarction; Myocardial Ischemia; Netherlands; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Research Design; Ticlopidine; Troponin T; Vascular Surgical Procedures | 2010 |
Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient Outcomes) PLATELET substudy.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Blood Platelets; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Enhanced platelet inhibition by adjunctive cilostazol to dual antiplatelet therapy after drug-eluting stent implantation for complex lesions.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Tetrazoles; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Female; Half-Life; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Proton Pump Inhibitors; Ticlopidine; Young Adult | 2011 |
Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: results of the SWAP (SWitching Anti Platelet) study.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2010 |
Level of adenosine diphosphate receptor P2Y12 blockade during percutaneous coronary intervention predicts the extent of endothelial injury, assessed by circulating endothelial cell measurement.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Endothelial Cells; Endothelium, Vascular; Female; Humans; Male; Platelet Aggregation Inhibitors; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Vascular Diseases | 2010 |
Pharmacodynamic effects of concomitant versus staggered clopidogrel and omeprazole intake: results of a prospective randomized crossover study.
Topics: Adult; Clinical Protocols; Clopidogrel; Drug Incompatibility; Drug Interactions; Female; Humans; Male; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
[Implantation of the paclitaxel-eluting stent Apollo in patients with stable angina pectoris: long-term angiographic and clinical results].
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
Prehospital triple antiplatelet therapy in patients with acute ST elevation myocardial infarction leads to better platelet aggregation inhibition and clinical outcome than dual antiplatelet therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2010 |
Clopidogrel with or without omeprazole in coronary artery disease.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Long-term clinical outcome based on aspirin and clopidogrel responsiveness status after elective percutaneous coronary intervention: a 3T/2R (tailoring treatment with tirofiban in patients showing resistance to aspirin and/or resistance to clopidogrel) tr
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Elective Surgical Procedures; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Prospective Studies; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Tyrosine | 2010 |
Comparison of effects of two different formulations of clopidogrel bisulfate tablets on platelet aggregation and bleeding time in healthy Korean volunteers: A single-dose, randomized, open-label, 1-week, two-period, phase IV crossover study.
Topics: Administration, Oral; Adult; Bleeding Time; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Korea; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Tablets; Therapeutic Equivalency; Ticlopidine; Young Adult | 2010 |
Stability of the high on-treatment platelet reactivity phenotype over time in clopidogrel-treated patients.
Topics: Adenosine Diphosphate; Clopidogrel; Double-Blind Method; Drug Monitoring; Humans; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Time | 2011 |
Effects of CYP2C19 genotype on outcomes of clopidogrel treatment.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Atrial Fibrillation; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Hemorrhage; Humans; Male; Middle Aged; Mutation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
The effect of St John's Wort on the pharmacodynamic response of clopidogrel in hyporesponsive volunteers and patients: increased platelet inhibition by enhancement of CYP3A4 metabolic activity.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Double-Blind Method; Female; Humans; Hypericum; Liver; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2011 |
[Impact of different proton pump inhibitors on the antiplatelet activity of clopidogrel in combination with aspirin for patients undergoing coronary stent implantation].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Angioplasty, Balloon; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Aggregation; Postoperative Period; Proton Pump Inhibitors; Stents; Ticlopidine | 2010 |
Aspirin plus clopidogrel therapy increases early venous graft patency after coronary artery bypass surgery a single-center, randomized, controlled trial.
Topics: Administration, Oral; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Saphenous Vein; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Vascular Patency | 2010 |
Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Electrocardiography; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Antagonism of P2Y₁₂ reduces physiological thromboxane levels.
Topics: Adenosine Diphosphate; Adolescent; Adult; Animals; Blood Platelets; Clopidogrel; Female; Humans; Male; Mice; Mice, Knockout; Middle Aged; Pilot Projects; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Thromboxanes; Ticlopidine; Young Adult | 2010 |
First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studies.
Topics: Adenosine; Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Double-Blind Method; Genotype; Humans; Male; Middle Aged; Pharmacokinetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2010 |
Effect of omeprazole on the concentration of interleukin-6 and transforming growth factor-β1 in patients receiving dual antiplatelet therapy after percutaneous coronary intervention.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Biomarkers; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Gene Expression Regulation; Humans; Interleukin-6; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Predictive Value of Tests; Ticlopidine; Transforming Growth Factor beta1; Treatment Outcome | 2010 |
Pretreatment with different loading doses of clopidogrel influences P-selectin levels in patients undergoing percutaneous coronary intervention: results from the ARMYDA-2 (antiplatelet therapy for reduction of myocardial damage during angioplasty) SELECT
Topics: Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Biomarkers; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Administration Schedule; Female; Heart Diseases; Humans; Italy; Male; Middle Aged; P-Selectin; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome; Troponin I | 2011 |
Safety and efficacy of prasugrel compared with clopidogrel in different regions of the world.
Topics: Acute Coronary Syndrome; Cause of Death; Clopidogrel; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Global Health; Humans; Incidence; Male; Middle Aged; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Thiophenes; Ticlopidine; Treatment Outcome | 2012 |
Randomized comparison of 6- versus 24-month clopidogrel therapy after balancing anti-intimal hyperplasia stent potency in all-comer patients undergoing percutaneous coronary intervention Design and rationale for the PROlonging Dual-antiplatelet treatment
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Coronary Restenosis; Coronary Vessels; Dose-Response Relationship, Drug; Drug-Eluting Stents; Follow-Up Studies; Humans; Hyperplasia; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome; Tunica Intima | 2010 |
Troponin-positive, MB-negative patients with non-ST-elevation myocardial infarction: An undertreated but high-risk patient group: Results from the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network-Get With Th
Topics: Aged; Aged, 80 and over; Antithrombins; Biomarkers; Clopidogrel; Coronary Angiography; Creatine Kinase, MB Form; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prognosis; Registries; Retrospective Studies; Risk Factors; Ticlopidine; Troponin; United States | 2010 |
Clopidogrel responsiveness regardless of the discontinuation date predicts increased blood loss and transfusion requirement after off-pump coronary artery bypass graft surgery.
Topics: Aged; Blood Loss, Surgical; Blood Platelets; Blood Transfusion; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Thrombelastography; Ticlopidine | 2010 |
Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the clopidogrel after surgery for coronary artery disease (CASCADE) Trial.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Hyperplasia; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Saphenous Vein; Ticlopidine; Treatment Outcome; Tunica Intima; Ultrasonography, Interventional | 2010 |
Sulfonylureas and on-clopidogrel platelet reactivity in type 2 diabetes mellitus patients.
Topics: Aged; Blood Platelets; Clopidogrel; Cohort Studies; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Drug Interactions; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Sulfonylurea Compounds; Ticlopidine | 2011 |
Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis.
Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Endoscopy, Gastrointestinal; Esomeprazole; Female; Genotype; Humans; Male; Middle Aged; Peptic Ulcer; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Risk Assessment; Secondary Prevention; Taiwan; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Randomized trial of aspirin and clopidogrel versus aspirin alone for the prevention of coronary artery bypass graft occlusion: the Preoperative Aspirin and Postoperative Antiplatelets in Coronary Artery Bypass Grafting study.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Double-Blind Method; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Myocardial Ischemia; Pilot Projects; Platelet Aggregation Inhibitors; Postoperative Care; Preoperative Care; Prospective Studies; Ticlopidine; Treatment Outcome | 2010 |
Comparison of adverse cardiovascular events and bleeding complications of loading dose of clopidogrel 300 mg versus 600 mg in stable patients undergoing elective percutaneous intervention (from the CADICE study).
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Cilostazol reduces the progression of carotid intima-media thickness without increasing the risk of bleeding in patients with acute coronary syndrome during a 2-year follow-up.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Analysis of Variance; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents; Aspirin; Carotid Arteries; Carotid Stenosis; Chi-Square Distribution; Cilostazol; Clopidogrel; Coronary Angiography; Disease Progression; Drug Therapy, Combination; Hemorrhage; Humans; Inflammation Mediators; Middle Aged; Phosphodiesterase 3 Inhibitors; Platelet Aggregation Inhibitors; Prospective Studies; Republic of Korea; Risk Assessment; Risk Factors; Single-Blind Method; Stents; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography | 2011 |
The safety of proton pump inhibitors and clopidogrel in patients after stroke.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Ontario; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Stroke; Ticlopidine; Time Factors | 2011 |
Randomized comparison of platelet function monitoring to adjust antiplatelet therapy versus standard of care: rationale and design of the assessment with a double randomization of (1) a fixed dose versus a monitoring-guided dose of aspirin and clopidogrel
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Monitoring, Physiologic; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Clopidogrel resistance is associated with long-term thrombotic events in patients implanted with drug-eluting stents.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Resistance; Drug-Eluting Stents; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2010 |
A randomized pilot trial for aggressive therapeutic approaches in aspirin-resistant patients undergoing percutaneous coronary intervention.
Topics: Adult; Angioplasty, Balloon, Coronary; Antithrombins; Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Ticlopidine | 2011 |
Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trial.
Topics: Aged; Aspirin; Brain Ischemia; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Sample Size; Ticlopidine; Treatment Outcome | 2011 |
Effects of clopidogrel on the pharmacokinetics of sibutramine and its active metabolites.
Topics: Adult; Appetite Depressants; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Pressure; Clopidogrel; Cyclobutanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Genotype; Half-Life; Heart Rate; Humans; Male; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Selective Serotonin Reuptake Inhibitors; Ticlopidine; Young Adult | 2011 |
Non-invasive alternating current stimulation induces recovery from stroke.
Topics: Aged; Aphasia; Aspirin; Brain Ischemia; Clopidogrel; Combined Modality Therapy; Electric Stimulation Therapy; Electroencephalography; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recovery of Function; Severity of Illness Index; Stroke; Stroke Rehabilitation; Ticlopidine; Treatment Outcome | 2010 |
Mortality benefit in PLATO cannot be explained by antiplatelet properties of ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2010 |
Tailored antiplatelet therapy can overcome clopidogrel and aspirin resistance--the BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Demography; Drug Resistance; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Receptors, Purinergic P2; Risk Factors; Thiophenes; Ticlopidine | 2011 |
Multicenter randomized trial evaluating the efficacy of cilostazol on ischemic vascular complications after drug-eluting stent implantation for coronary heart disease: results of the CILON-T (influence of CILostazol-based triple antiplatelet therapy ON is
Topics: Aged; Aspirin; Brain Ischemia; Cilostazol; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Tetrazoles; Ticlopidine; Treatment Outcome | 2011 |
The EFFect of hIgh-dose ClopIdogrel treatmENT in patients with clopidogrel resistance (the EFFICIENT trial).
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2012 |
A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 Trial.
Topics: Adolescent; Adult; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Thiophenes; Ticlopidine; Treatment Outcome; Young Adult | 2011 |
Clopidogrel versus dipyridamole in addition to aspirin in reducing embolization detected with ambulatory transcranial Doppler: a randomized trial.
Topics: Aged; Aged, 80 and over; Ambulatory Care; Aspirin; Clopidogrel; Dipyridamole; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Stroke; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2011 |
Safety of clopidogrel in older patients: a nonrandomized, parallel-group, controlled, two-centre study.
Topics: Acute Coronary Syndrome; Administration, Cutaneous; Age Factors; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Stents; Stroke; Thrombocytopenia; Ticlopidine; Treatment Outcome | 2011 |
Upstream clopidogrel use and the efficacy and safety of early eptifibatide treatment in patients with acute coronary syndrome: an analysis from the Early Glycoprotein IIb/IIIa Inhibition in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome (E
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Electrocardiography; Eptifibatide; Hemorrhage; Humans; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Ticlopidine; Treatment Outcome | 2011 |
High versus standard clopidogrel maintenance dose after percutaneous coronary intervention and effects on platelet inhibition, endothelial function, and inflammation results of the ARMYDA-150 mg (antiplatelet therapy for reduction of myocardial damage dur
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Platelets; C-Reactive Protein; Clopidogrel; Endothelial Cells; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2011 |
Impact of reduced glomerular filtration rate on outcomes in patients with ST-segment elevation myocardial infarction undergoing fibrinolysis: a CLARITY-TIMI 28 analysis.
Topics: Adolescent; Adult; Aged; Clopidogrel; Coronary Angiography; Female; Fibrinolysis; Glomerular Filtration Rate; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 2011 |
Separate dosing of clopidogrel and omeprazole may improve platelet inhibition on dual antiplatelet therapy.
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Omeprazole; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Cilostazol attenuates on-treatment platelet reactivity in patients with CYP2C19 loss of function alleles receiving dual antiplatelet therapy: a genetic substudy of the CILON-T randomised controlled trial.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Aspirin; Cardiovascular Diseases; Cilostazol; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Drug-Eluting Stents; Epidemiologic Methods; Female; Humans; Korea; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Tetrazoles; Ticlopidine; Treatment Outcome | 2011 |
The Secondary Prevention of Small Subcortical Strokes (SPS3) study.
Topics: Antihypertensive Agents; Aspirin; Clopidogrel; Cognition Disorders; Humans; Hypertension; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Research Design; Secondary Prevention; Stroke; Ticlopidine | 2011 |
A case-control study on platelet reactivity in patients with coronary stent thrombosis.
Topics: Aged; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Coronary Thrombosis; Female; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine; Treatment Outcome; Vasodilator Agents | 2011 |
Influence of abciximab on evolution of left ventricular function in patients with non-ST-segment elevation acute coronary syndromes undergoing PCI after clopidogrel pretreatment: lessons from the ISAR-REACT 2 trial.
Topics: Abciximab; Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke Volume; Ticlopidine; Treatment Outcome; Troponin; Ventricular Function, Left | 2011 |
A randomized, double-blind, multicenter comparison study of triple antiplatelet therapy with dual antiplatelet therapy to reduce restenosis after drug-eluting stent implantation in long coronary lesions: results from the DECLARE-LONG II (Drug-Eluting Sten
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Double-Blind Method; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Radiography; Tetrazoles; Ticlopidine; Treatment Outcome | 2011 |
High-sensitivity C-reactive protein and clopidogrel treatment in patients at high risk of cardiovascular events: a substudy from the CHARISMA trial.
Topics: Aged; Aspirin; Atherosclerosis; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk; Thrombosis; Ticlopidine | 2011 |
Trans-radial approach for catheterisation in non-ST segment elevation acute coronary syndrome: an analysis of major bleeding complications in the ABOARD Study.
Topics: Abciximab; Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Omeprazole, but not pantoprazole, reduces the antiplatelet effect of clopidogrel: a randomized clinical crossover trial in patients after myocardial infarction evaluating the clopidogrel-PPIs drug interaction.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Blood Platelets; Clopidogrel; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Long-term reduction of mortality in the 4-year follow up of tirofiban therapy in elective percutaneous coronary interventions (TOPSTAR) trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Platelet Glycoprotein GPIIb-IIIa Complex; Survival Rate; Ticlopidine; Tirofiban; Treatment Outcome; Troponin; Tyrosine | 2011 |
High on-treatment platelet reactivity to both aspirin and clopidogrel is associated with the highest risk of adverse events following percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Female; Graft Occlusion, Vascular; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Stents; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Frequency and predictors of stent thrombosis after percutaneous coronary intervention in acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Antithrombins; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Heparin; Hirudins; Humans; Male; Metals; Middle Aged; Myocardial Infarction; Paclitaxel; Peptide Fragments; Platelet Aggregation Inhibitors; Predictive Value of Tests; Recombinant Proteins; Risk Factors; Ticlopidine; Treatment Outcome; Tubulin Modulators | 2011 |
Platelet inhibition by adjunctive cilostazol versus high maintenance-dose clopidogrel in patients with acute myocardial infarction according to cytochrome P450 2C19 genotype.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Chi-Square Distribution; Cilostazol; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Genotype; Humans; Korea; Liver; Male; Middle Aged; Myocardial Infarction; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Regression Analysis; Risk Assessment; Risk Factors; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
High doses of clopidogrel to overcome genetic resistance: the randomized crossover CLOVIS-2 (Clopidogrel and Response Variability Investigation Study 2).
Topics: Adenosine Diphosphate; Adult; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Bypass; Cross-Over Studies; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Resistance; Female; France; Gene Dosage; Heterozygote; Homozygote; Humans; Male; Middle Aged; Myocardial Infarction; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Registries; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2011 |
Prasugrel overcomes high on-clopidogrel platelet reactivity post-stenting more effectively than high-dose (150-mg) clopidogrel: the importance of CYP2C19*2 genotyping.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Chi-Square Distribution; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Resistance; Drug Therapy, Combination; Female; Genotype; Greece; Humans; Least-Squares Analysis; Male; Middle Aged; Phenotype; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymerase Chain Reaction; Prasugrel Hydrochloride; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Single-Blind Method; Stents; Thiophenes; Ticlopidine; Treatment Outcome | 2011 |
Omeprazole affects clopidogrel efficacy but not ischemic events in patients with acute coronary syndrome undergoing elective percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Pharmacodynamic evaluation of pantoprazole therapy on clopidogrel effects: results of a prospective, randomized, crossover study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Male; Microfilament Proteins; Pantoprazole; Phosphoproteins; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Receptors, Purinergic P2Y12; Ticlopidine | 2011 |
The effects of laropiprant, a selective prostaglandin D₂ receptor 1 antagonist, on the antiplatelet activity of clopidogrel or aspirin.
Topics: Adolescent; Adult; Aspirin; Bleeding Time; Blood Platelets; Clopidogrel; Female; Humans; Indoles; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Immunologic; Receptors, Prostaglandin; Ticlopidine; Young Adult | 2011 |
Modifying clopidogrel maintenance doses according to vasodilator-stimulated phosphoprotein phosphorylation index improves clinical outcome in patients with clopidogrel resistance.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Coronary Angiography; Drug Resistance; Female; Humans; Kaplan-Meier Estimate; Male; Microfilament Proteins; Phosphoproteins; Platelet Aggregation Inhibitors; Statistics as Topic; Ticlopidine; Treatment Outcome; Vasodilation | 2011 |
The incidence of bradyarrhythmias and clinical bradyarrhythmic events in patients with acute coronary syndromes treated with ticagrelor or clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) trial: results of the continuous electrocardiogr
Topics: Acute Coronary Syndrome; Adenosine; Aged; Bradycardia; Clopidogrel; Electrocardiography; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
A high maintenance dose increases the inhibitory response to clopidogrel in patients with high on-treatment residual platelet reactivity.
Topics: Aged; Clopidogrel; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Fibrin Fibrinogen Degradation Products; Fibrinolytic Agents; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Ticlopidine; Treatment Outcome | 2011 |
Platelet response to aspirin and clopidogrel in patients with peripheral atherosclerosis.
Topics: Aged; Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2011 |
A randomized two-by-two comparison of high-dose bolus tirofiban versus abciximab and unfractionated heparin versus bivalirudin during percutaneous coronary revascularization and stent placement: the tirofiban evaluation of novel dosing versus abciximab wi
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Heparin; Hirudins; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Tyrosine; United States | 2011 |
Predictors of bleeding and time dependence of association of bleeding with mortality: insights from the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel--Thrombolysis in Myocardial Infarction 38 (TRITON-
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Predictive Value of Tests; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Risk Factors; Thiophenes; Thrombolytic Therapy; Ticlopidine | 2011 |
Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapy.
Topics: Aged; Aspirin; Blood Platelets; Chemotherapy, Adjuvant; Cilostazol; Clopidogrel; Cross-Over Studies; Diabetes Mellitus; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Receptors, Purinergic P2Y12; Signal Transduction; Tetrazoles; Thrombin; Ticlopidine | 2011 |
Reduced thrombin formation and altered fibrin clot properties induced by polyunsaturated omega-3 fatty acids on top of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention (OMEGA-PCI clot).
Topics: Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Coagulation; C-Reactive Protein; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Dinoprost; Double-Blind Method; Down-Regulation; Drug Therapy, Combination; Fatty Acids, Omega-3; Female; Fibrin; Humans; Linear Models; Male; Middle Aged; Oxidative Stress; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Poland; Prospective Studies; Prothrombin; Thrombin; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: beyond aspirin and clopidogrel.
Topics: Adult; Aspirin; Bleeding Time; Blood Platelets; Chi-Square Distribution; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Omega-3; Female; Hemorrhage; Humans; Male; Middle Aged; North Carolina; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Surface Properties; Ticlopidine; Time Factors | 2011 |
Variability in on-treatment platelet reactivity explained by CYP2C19*2 genotype is modest in clopidogrel pretreated patients undergoing coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Cytochrome P-450 CYP2C19; DNA; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Preoperative Period; Prognosis; Prospective Studies; Stents; Ticlopidine | 2011 |
Low platelet reactivity is recovered by transfusion of stored platelets: a healthy volunteer in vivo study.
Topics: Adenosine Diphosphate; Aryl Hydrocarbon Hydroxylases; Austria; Blood Platelets; Blood Transfusion, Autologous; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Microfilament Proteins; Phosphoproteins; Phosphorylation; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Platelet Transfusion; Polymorphism, Single Nucleotide; Ticlopidine | 2011 |
Clopidogrel up-titration versus standard dose in patients with high residual platelet reactivity after percutaneous coronary intervention: a single-center pilot randomised study.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pilot Projects; Platelet Activation; Ticlopidine | 2011 |
Paraoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement.
Topics: Aryldialkylphosphatase; Clopidogrel; Elective Surgical Procedures; Genotype; Humans; Mutation, Missense; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Stents; Ticlopidine | 2011 |
Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prospective Studies; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
Pharmacokinetics and pharmacodynamics following maintenance doses of prasugrel and clopidogrel in Chinese carriers of CYP2C19 variants.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Pedigree; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Young Adult | 2012 |
Relationship between paraoxonase-1 activity, its Q192R genetic variant and clopidogrel responsiveness in the ADRIE study.
Topics: Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Genetic Variation; Genotype; Humans; Myocardial Ischemia; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2011 |
Randomized double-blind placebo-controlled crossover study to determine the effects of esomeprazole on inhibition of platelet function by clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Phenotype; Phosphoproteins; Placebo Effect; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Risk Assessment; Ticlopidine; Time Factors; Victoria | 2011 |
Comparison of titanium-nitride-oxide-coated stents with zotarolimus-eluting stents for coronary revascularization a randomized controlled trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Confidence Intervals; Coronary Angiography; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Logistic Models; Male; Middle Aged; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Risk Factors; Sirolimus; Statistics as Topic; Statistics, Nonparametric; Switzerland; Ticlopidine; Titanium | 2011 |
Association of cytochrome P450 2C19*2 polymorphism with clopidogrel response variability and cardiovascular events in Koreans treated with drug-eluting stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Registries; Republic of Korea; Ticlopidine; Treatment Outcome | 2012 |
Earlier recovery of platelet function after discontinuation of treatment with ticagrelor compared with clopidogrel in patients with high antiplatelet responses.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Time Factors | 2011 |
Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial.
Topics: Adenosine; Aged; Aspirin; Clopidogrel; Combined Modality Therapy; Female; Global Health; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Risk Factors; Stroke; Ticagrelor; Ticlopidine; United States | 2011 |
Residual platelet reactivity after clopidogrel loading in patients with ST-elevation myocardial infarction undergoing an unexpectedly delayed primary percutaneous coronary intervention. - Impact on intracoronary thrombus burden and myocardial perfusion-.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Circulation; Coronary Thrombosis; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2011 |
Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2011 |
Genetic polymorphisms and the impact of a higher clopidogrel dose regimen on active metabolite exposure and antiplatelet response in healthy subjects.
Topics: Adenosine Diphosphate; Adult; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Young Adult | 2011 |
Randomised clinical trial: rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Rabeprazole; Regression Analysis; Ticlopidine; Treatment Outcome | 2011 |
Combined clopidogrel and proton pump inhibitor therapy is associated with higher cardiovascular event rates after percutaneous coronary intervention: a report from the BASKET trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2012 |
Bleeding, mortality, and antiplatelet therapy: results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial.
Topics: Aged; Atherosclerosis; Cause of Death; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Global Health; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Risk Factors; Survival Rate; Thrombosis; Ticlopidine | 2011 |
The effect of ticagrelor versus clopidogrel on high on-treatment platelet reactivity: combined analysis of the ONSET/OFFSET and RESPOND studies.
Topics: Adenosine; Administration, Oral; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Higher efficacy of pre-hospital tirofiban with longer pre-treatment time to primary PCI: protection for the negative impact of time delay.
Topics: Aged; Ambulances; Angioplasty, Balloon, Coronary; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Emergency Medical Services; Female; Fibrinolytic Agents; Health Services Accessibility; Heparin; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Netherlands; Outcome and Process Assessment, Health Care; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Tyrosine | 2011 |
Doubling the dose of clopidogrel restores the loss of antiplatelet effect induced by esomeprazole.
Topics: Aged; Anti-Ulcer Agents; Aspirin; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Ranitidine; Ticlopidine | 2011 |
Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study.
Topics: Aged; Biomarkers; C-Reactive Protein; CD40 Ligand; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Inflammation; Interleukin-6; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Thromboxane B2; Ticlopidine; Time Factors; Withholding Treatment | 2011 |
Efficacy and safety of combination antiplatelet therapies in patients with symptomatic intracranial atherosclerotic stenosis.
Topics: Aged; Aged, 80 and over; Cilostazol; Clopidogrel; Constriction, Pathologic; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Intracranial Arteriosclerosis; Ischemia; Male; Middle Aged; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Treatment Outcome | 2011 |
Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Double-Blind Method; Dyspnea; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
Impact of genetic variants on post-clopidogrel platelet reactivity in patients after elective percutaneous coronary intervention.
Topics: Aged; Alleles; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Adhesion Molecules; Clopidogrel; Coronary Stenosis; Cytochrome P-450 CYP2C19; Female; Gene Dosage; Genetic Association Studies; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine; Treatment Outcome | 2011 |
The effect of the duration of clopidogrel use on hsCRP levels after stenting the target vessel in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; C-Reactive Protein; Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Comparison of antiplatelet effect and tolerability of clopidogrel resinate with clopidogrel bisulfate in patients with coronary heart disease (CHD) or CHD-equivalent risks: a phase IV, prospective, double-dummy, parallel-group, 4-week noninferiority trial
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2011 |
Effect of hydroxyethyl starch 130/0.4 on blood loss and coagulation in patients with recent exposure to dual antiplatelet therapy undergoing off-pump coronary artery bypass graft surgery.
Topics: Aged; Aspirin; Blood Coagulation; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Crystalloid Solutions; Female; Hemoglobins; Hemorrhage; Humans; Hydroxyethyl Starch Derivatives; Isotonic Solutions; Male; Middle Aged; Perioperative Care; Plasma Substitutes; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
CYP2C19*2 and other genetic variants affecting platelet response to clopidogrel in patients undergoing percutaneous coronary intervention.
Topics: Clopidogrel; Comorbidity; Coronary Artery Disease; Cytokines; Female; Genetic Predisposition to Disease; Greece; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Prevalence; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Relationship between clopidogrel-induced platelet P2Y12 inhibition and stent thrombosis or myocardial infarction after percutaneous coronary intervention-a case-control study.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Prosthesis Failure; Receptors, Purinergic P2Y12; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2011 |
Impact of pentoxifylline on platelet function profiles in patients with type 2 diabetes mellitus and coronary artery disease on dual antiplatelet therapy with aspirin and clopidogrel.
Topics: Aged; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Florida; Humans; Male; Microfilament Proteins; Middle Aged; Pentoxifylline; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Inhibitory interaction between calcium channel blocker and clopidogrel. -Efficacy of cilostazol to overcome it-.
Topics: Aged; Brain Ischemia; Calcium Channel Blockers; Cilostazol; Clopidogrel; Death; Drug Antagonism; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Stroke; Tetrazoles; Ticlopidine | 2011 |
Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention: a time-dependent analysis of the Gauging Responsiveness with a VerifyNow P2Y12 assay: Impact on Thrombosis and Safety (GRAVITAS) trial.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Clinical outcomes of high on-treatment platelet reactivity in Koreans receiving elective percutaneous coronary intervention (from results of the CROSS VERIFY study).
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Stenosis; Elective Surgical Procedures; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Republic of Korea; Risk Factors; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Paraoxonase 1 (PON1) gene variants are not associated with clopidogrel response.
Topics: Adult; Aged; Aryldialkylphosphatase; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Genetic Association Studies; Genetic Variation; Humans; Male; Middle Aged; Survival Rate; Ticlopidine; Treatment Outcome | 2011 |
Impact of smoking on antiplatelet effect of clopidogrel and prasugrel after loading dose and on maintenance therapy.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Smoking; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Pulmonary function in patients with acute coronary syndrome treated with ticagrelor or clopidogrel (from the Platelet Inhibition and Patient Outcomes [PLATO] pulmonary function substudy).
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Middle Aged; Oxygen Consumption; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Respiratory Function Tests; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Reversal of clopidogrel-induced bleeding with rFVIIa in healthy subjects: a randomized, placebo-controlled, double-blind, exploratory study.
Topics: Adult; Biopsy; Clopidogrel; Double-Blind Method; Factor VIIa; Hemorrhage; Hemostasis; Hemostatics; Humans; Male; New Jersey; Placebo Effect; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Recombinant Proteins; Thrombelastography; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2011 |
Stenting versus aggressive medical therapy for intracranial arterial stenosis.
Topics: Aged; Antihypertensive Agents; Aspirin; Clopidogrel; Combined Modality Therapy; Female; Follow-Up Studies; Health Behavior; Humans; Intracranial Arteriosclerosis; Intracranial Hemorrhages; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine | 2011 |
Justification of 150 mg clopidogrel in patients with high on-clopidogrel platelet reactivity.
Topics: Aged; Angina, Stable; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Thrombosis; Ticlopidine; Time Factors | 2012 |
Dual antiplatelet therapy versus aspirin alone in patients undergoing transcatheter aortic valve implantation.
Topics: Aged, 80 and over; Aortic Valve; Aortic Valve Stenosis; Aspirin; Catheters; Clopidogrel; Drug Therapy, Combination; Female; Heart Valve Prosthesis Implantation; Humans; Male; Platelet Aggregation Inhibitors; Severity of Illness Index; Single-Blind Method; Ticlopidine | 2011 |
Coronary stenting with the Genous™ Bio-Engineered R Stent™ in elderly patients.
Topics: Age Factors; Aged; Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis; Clopidogrel; Death; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Registries; Risk Factors; Stents; Thrombosis; Ticlopidine | 2011 |
A randomized clinical trial comparing point-of-care platelet function assays and bleeding time in healthy subjects treated with aspirin or clopidogrel.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Aspirin; Bleeding Time; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Ticlopidine; Young Adult | 2012 |
Pharmacokinetics and platelet aggregation inhibitory effects of a novel intravenous formulation of clopidogrel in humans.
Topics: Adult; beta-Cyclodextrins; Biotransformation; Clopidogrel; Dose-Response Relationship, Drug; Drug Compounding; Excipients; Female; Half-Life; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2012 |
Outcome comparison of 600- and 300-mg loading doses of clopidogrel in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: results from the ARMYDA-6 MI (Antiplatelet therapy for Reduction of MYocar
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
CYP2C19 but not PON1 genetic variants influence clopidogrel pharmacokinetics, pharmacodynamics, and clinical efficacy in post-myocardial infarction patients.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Biomarkers, Pharmacological; Clopidogrel; Cohort Studies; Cross-Over Studies; Cytochrome P-450 CYP2C19; DNA Mutational Analysis; Female; Genotype; Humans; Male; Mutation; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Risk Factors; Survival Analysis; Ticlopidine; Treatment Outcome | 2011 |
Prasugrel overcomes high on-clopidogrel platelet reactivity in chronic coronary artery disease patients more effectively than high dose (150 mg) clopidogrel.
Topics: Aged; Chronic Disease; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Female; Humans; Male; Middle Aged; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Single-Blind Method; Thiophenes; Ticlopidine; Treatment Outcome | 2011 |
Antiplatelet effects of prasugrel vs. double clopidogrel in patients on hemodialysis and with high on-treatment platelet reactivity.
Topics: Aged; Blood Platelets; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Renal Dialysis; Single-Blind Method; Thiophenes; Ticlopidine | 2011 |
Spot drug-eluting stenting for long coronary stenoses: long-term results of a randomized clinical study.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Drug-Eluting Stents; Enoxaparin; Female; Humans; Male; Proportional Hazards Models; Risk Assessment; Severity of Illness Index; Ticlopidine; Time Factors; Ultrasonography, Interventional | 2011 |
Effects of omeprazole and genetic polymorphism of CYP2C19 on the clopidogrel active metabolite.
Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Female; Humans; Male; Microsomes, Liver; Middle Aged; Omeprazole; Polymorphism, Genetic; Ticlopidine | 2012 |
Assessing the temporal course of neointimal hyperplasia formation after different generations of drug-eluting stents.
Topics: Clopidogrel; Coronary Angiography; Coronary Restenosis; Diabetes Mellitus; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Middle Aged; Neointima; Risk Factors; Sirolimus; Statistics as Topic; Statistics, Nonparametric; Ticlopidine; Time Factors; Ultrasonography, Interventional | 2011 |
Optimal timing of discontinuation of clopidogrel and risk of blood transfusion after coronary surgery. Propensity score analysis.
Topics: Aged; Aspirin; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Risk Factors; Ticlopidine | 2011 |
Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Sensitivity and Specificity; Stroke; Ticlopidine; Vitamin K | 2011 |
Pharmacodynamic evaluation of clopidogrel plus PA32540: the Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) study.
Topics: Adult; Anti-Ulcer Agents; Aspirin; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; Humans; Least-Squares Analysis; Male; Omeprazole; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Ticlopidine | 2011 |
A novel regimen of alternate day clopidogrel would provide a cost-effective strategy to prevent very late stent thrombosis.
Topics: Aspirin; Clopidogrel; Cohort Studies; Coronary Thrombosis; Drug-Eluting Stents; Equipment Safety; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Clopidogrel tapering as a strategy to attenuate platelet rebound phenomenon in patients with bare-metal stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Prospective Studies; Stents; Ticlopidine | 2012 |
Evaluating the safety of very short-term (10 days) dual antiplatelet therapy after Genous™ bio-engineered R stent™ implantation: the multicentre pilot Genous trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Stenosis; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Italy; Male; Middle Aged; Myocardial Infarction; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Prosthesis Design; Severity of Illness Index; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Double-Blind Method; Female; Genotype; Heterozygote; Homozygote; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2011 |
Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
Effect of esomeprazole versus famotidine on platelet inhibition by clopidogrel: a double-blind, randomized trial.
Topics: Acute Coronary Syndrome; Anti-Ulcer Agents; Blood Platelets; Clopidogrel; Double-Blind Method; Esomeprazole; Famotidine; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2011 |
Incidence, predictors, and 30-day outcomes of new-onset atrial fibrillation after primary percutaneous coronary intervention: insight into the RISK-PCI trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Atrial Fibrillation; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Female; Hospital Mortality; Humans; Incidence; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Serbia; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarction.
Topics: Acute Coronary Syndrome; Aged; Anti-Ulcer Agents; Aspirin; Chi-Square Distribution; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Enoxaparin; Esomeprazole; Famotidine; Female; Fibrinolytic Agents; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Intestinal Perforation; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Ticlopidine; Treatment Outcome | 2012 |
Cystatin C and estimated glomerular filtration rate as predictors for adverse outcome in patients with ST-elevation and non-ST-elevation acute coronary syndromes: results from the Platelet Inhibition and Patient Outcomes study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Biomarkers; C-Reactive Protein; Clopidogrel; Creatinine; Cystatin C; Double-Blind Method; Endpoint Determination; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Peptide Fragments; Platelet Aggregation Inhibitors; Predictive Value of Tests; Proportional Hazards Models; Protein Precursors; Ticagrelor; Ticlopidine; Troponin I | 2012 |
Clopidogrel pharmacodynamics and pharmacokinetics in the fed and fasted state: a randomized crossover study of healthy men.
Topics: Adenosine Diphosphate; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Breakfast; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Diet, High-Fat; Food-Drug Interactions; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2012 |
Platelet reactivity in patients with chronic kidney disease receiving adjunctive cilostazol compared with a high-maintenance dose of clopidogrel: results of the effect of platelet inhibition according to clopidogrel dose in patients with chronic kidney di
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Chronic Disease; Cilostazol; Clopidogrel; Coronary Artery Disease; Female; Humans; Kidney Diseases; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Renal Dialysis; Tetrazoles; Ticlopidine | 2011 |
Antiplatelet efficacy of long-term treatment with clopidogrel besylate in patients with a history of acute coronary syndrome: comparison with clopidogrel hydrogen sulfate.
Topics: Acute Coronary Syndrome; Clopidogrel; Drugs, Generic; Humans; Long-Term Care; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2012 |
[Tirofiban improved the prognosis of senior acute coronary syndrome patients received percutaneous coronary intervention].
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine; Tirofiban; Tyrosine | 2011 |
The effect of pre-hospital glycoprotein IIb-IIIa inhibitors on angiographic outcome in STEMI patients who are candidates for primary PCI.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Circulation; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Emergency Medical Services; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Predictive Value of Tests; Prospective Studies; Severity of Illness Index; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Tyrosine; Vascular Patency | 2012 |
Use of tailored loading-dose clopidogrel in patients undergoing selected percutaneous coronary intervention based on adenosine diphosphate-mediated platelet aggregation.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2010 |
Pharmacodynamic assessment of a novel P2Y12 receptor antagonist in Japanese patients with coronary artery disease undergoing elective percutaneous coronary intervention.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Female; Humans; Japan; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Young Adult | 2012 |
ST-elevation acute coronary syndromes in the Platelet Inhibition and Patient Outcomes (PLATO) trial: insights from the ECG substudy.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Electrocardiography; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticagrelor; Ticlopidine | 2012 |
Six-month versus 12-month dual antiplatelet therapy after implantation of drug-eluting stents: the Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting (EXCELLENT) randomized, multicenter study.
Topics: Aged; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Disease; Coronary Restenosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2012 |
Efficacy and safety of a high loading dose of clopidogrel administered prehospitally to improve primary percutaneous coronary intervention in acute myocardial infarction: the randomized CIPAMI trial.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Emergency Medical Services; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors | 2012 |
Effect of clopidogrel besylate on platelet reactivity in patients with acute coronary syndromes. Comparison with clopidogrel hydrogen sulfate.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2012 |
High leukocyte count and interleukin-10 predict high on-treatment-platelet-reactivity in patients treated with clopidogrel.
Topics: Age Factors; Aged; Biomarkers; CD40 Ligand; Clopidogrel; Diabetes Mellitus; Drug Resistance; Female; Humans; Inflammation; Interleukin-10; Leukocyte Count; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Endothelial progenitor cell mobilization and platelet microparticle release are influenced by clopidogrel plasma levels in stable coronary artery disease.
Topics: Adult; Aged; Blood Platelets; Cell Movement; Cell-Derived Microparticles; Clopidogrel; Coronary Artery Disease; Endothelial Cells; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Protective Agents; Purinergic P2Y Receptor Antagonists; Stem Cells; Ticlopidine | 2012 |
The pattern of platelet response to clopidogrel in Iranian patients after percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Iran; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2012 |
Antiplatelet therapy for prevention of thromboembolic complications associated with coil embolization of unruptured cerebral aneurysms.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Female; Humans; Incidence; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Retrospective Studies; Thromboembolism; Ticlopidine; Treatment Outcome; Young Adult | 2012 |
Tailoring clopidogrel dose according to multiple electrode aggregometry decreases the rate of ischemic complications after percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Clopidogrel; Disease-Free Survival; Female; Humans; Male; Middle Aged; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine; Time Factors | 2012 |
Association of proton pump inhibitor use on cardiovascular outcomes with clopidogrel and ticagrelor: insights from the platelet inhibition and patient outcomes trial.
Topics: Adenosine; Aged; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
The impact of genetic polymorphisms of P2Y12, CYP3A5 and CYP2C19 on clopidogrel response variability in Iranian patients.
Topics: Aryl Hydrocarbon Hydroxylases; Blood Platelets; Catheter Ablation; Clopidogrel; Cross-Sectional Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug-Eluting Stents; Female; Humans; Iran; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2012 |
Risk of recurrent stroke in patients with silent brain infarction in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) imaging substudy.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Aspirin; Benzimidazoles; Benzoates; Brain Ischemia; Cerebral Infarction; Clopidogrel; Dipyridamole; Female; Humans; Intracranial Embolism; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Socioeconomic Factors; Stroke; Telmisartan; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Vasodilator Agents | 2012 |
Reversal of the anti-platelet effects of aspirin and clopidogrel.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Ontario; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Recovery of Function; Thromboxane B2; Ticlopidine; Time Factors | 2012 |
[Branch atheromatous disease: prognosis and management. The SPS3 experience].
Topics: Aspirin; Basilar Artery; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stroke; Stroke, Lacunar; Ticlopidine | 2011 |
Bioequivalence study of two clopidogrel film-coated tablet formulations in healthy volunteers.
Topics: Adolescent; Adult; Algorithms; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Single-Blind Method; Tablets, Enteric-Coated; Tandem Mass Spectrometry; Therapeutic Equivalency; Ticlopidine; Young Adult | 2011 |
Factors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockade.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Dosage Calculations; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2012 |
Pharmacodynamic effects of clopidogrel in pediatric cardiac patients: a comparative study of platelet aggregation response.
Topics: Adenosine Diphosphate; Adult; Arteries; Blood Platelets; Child, Preschool; Clopidogrel; Double-Blind Method; Female; Fetal Blood; Heart; Heart Diseases; Humans; Infant; Infant, Newborn; Male; Peptide Fragments; Placebos; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2012 |
Description of response to aspirin and clopidogrel in outpatients with coronary artery disease using multiple electrode impedance aggregometry.
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Placental Function Tests; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Bleeding-associated outcomes with preoperative clopidogrel use in on- and off-pump coronary artery bypass.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Hemorrhage; Humans; Length of Stay; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Retrospective Studies; Risk Factors; Ticlopidine | 2012 |
Effect of PON1 Q192R genetic polymorphism on clopidogrel efficacy and cardiovascular events in the Clopidogrel in the Unstable Angina to Prevent Recurrent Events trial and the Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascula
Topics: Adult; Aged; Angina, Unstable; Aryldialkylphosphatase; Atrial Fibrillation; Clopidogrel; Female; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Ticlopidine | 2012 |
A prospective randomized trial comparing the recovery of platelet function after loading dose administration of prasugrel or clopidogrel.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Net clinical benefit of prehospital glycoprotein IIb/IIIa inhibitors in patients with ST-elevation myocardial infarction and high risk of bleeding: effect of tirofiban in patients at high risk of bleeding using CRUSADE bleeding score.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Electrocardiography; Emergency Medical Services; Female; Hemorrhage; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prevalence; Retrospective Studies; Risk Factors; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2012 |
Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery: the timing based on platelet function strategy to reduce clopidogrel-associated bleeding rela
Topics: Aged; Blood Transfusion; Chest Tubes; Clopidogrel; Coronary Artery Bypass; Drainage; Female; Humans; Male; Middle Aged; Platelet Function Tests; Postoperative Hemorrhage; Practice Guidelines as Topic; Preoperative Care; Thrombelastography; Ticlopidine; Watchful Waiting | 2012 |
Loading effect of 200 mg cilostazol on platelet inhibition in patients undergoing percutaneous coronary intervention.
Topics: Adult; Aged; Aspirin; Cilostazol; Clopidogrel; Endovascular Procedures; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Tetrazoles; Ticlopidine | 2012 |
Closure or medical therapy for cryptogenic stroke with patent foramen ovale.
Topics: Adolescent; Adult; Anticoagulants; Aspirin; Clopidogrel; Combined Modality Therapy; Drug Therapy, Combination; Embolism, Paradoxical; Female; Foramen Ovale, Patent; Humans; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Prostheses and Implants; Secondary Prevention; Stroke; Ticlopidine; Warfarin; Young Adult | 2012 |
Pharmacodynamic effects of adjunctive cilostazol therapy in patients with coronary artery disease on dual antiplatelet therapy: impact of high on-treatment platelet reactivity and diabetes mellitus status.
Topics: Aged; Aspirin; Blood Platelets; Cilostazol; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Diabetic Angiopathies; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Radiography; Risk Assessment; Statistics, Nonparametric; Survival Analysis; Tetrazoles; Ticlopidine; Treatment Outcome | 2013 |
Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: a randomized multicenter trial.
Topics: Aged; Aged, 80 and over; Aspirin; Cause of Death; Clopidogrel; Coronary Restenosis; Coronary Vessels; Drug Therapy, Combination; Drug-Eluting Stents; Everolimus; Female; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Risk; Sirolimus; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Prasugrel versus tirofiban bolus with or without short post-bolus infusion with or without concomitant prasugrel administration in patients with myocardial infarction undergoing coronary stenting: the FABOLUS PRO (Facilitation through Aggrastat By drOppin
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Italy; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Predictive Value of Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Tyrosine | 2012 |
Prophylactic use of clopidogrel in paediatric cardiac patients.
Topics: Aspirin; Child; Child, Preschool; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Heart Defects, Congenital; Humans; Infant; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thromboembolism; Ticlopidine | 2012 |
Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score.
Topics: Age Factors; Aged; Aspirin; Body Weight; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Female; Fibrinolytic Agents; Humans; Hypertension; Injections, Intravenous; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Predictive Value of Tests; Registries; Risk Factors; Stroke; Ticlopidine; Tissue Plasminogen Activator | 2012 |
The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: the CHARISMA genetics study.
Topics: Aryl Hydrocarbon Hydroxylases; Atherosclerosis; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Hemorrhage; Heterozygote; Humans; Ischemia; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stroke; Thrombosis; Ticlopidine | 2012 |
Case report: use of thienopyridines in a patient with acquired idiopathic thrombotic thrombocytopenic purpura.
Topics: ADAM Proteins; ADAMTS13 Protein; Aged; Autoantibodies; Clopidogrel; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Ticlopidine | 2012 |
A randomized, 2-period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Area Under Curve; Blood Coagulation; Blood Platelets; Clopidogrel; Confidence Intervals; Cross-Over Studies; Dexlansoprazole; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Lansoprazole; Male; Middle Aged; Omeprazole; Proton Pump Inhibitors; Reference Values; Ticlopidine; Young Adult | 2012 |
Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Carrier Screening; Genetic Testing; Genotype; Humans; Loss of Heterozygosity; Male; Middle Aged; Pharmacogenetics; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prasugrel Hydrochloride; Precision Medicine; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2012 |
[Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention].
Topics: Adult; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Blood Coagulation; Case-Control Studies; Clopidogrel; Coronary Disease; Double-Blind Method; Female; Fibrin Fibrinogen Degradation Products; Fibrinolysis; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activating Factor; Prospective Studies; Ticlopidine; Tissue Plasminogen Activator; von Willebrand Factor | 2012 |
Platelet proteome and clopidogrel response in patients with stable angina undergoing percutaneous coronary intervention.
Topics: Aged; Angina, Stable; Angioplasty, Balloon, Coronary; Blood Platelets; Blotting, Western; Clopidogrel; Combined Modality Therapy; Dual Specificity Phosphatase 2; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Proteome; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Ticlopidine | 2012 |
Earlier application of loading doses of aspirin and clopidogrel decreases rate of recurrent cardiovascular ischemic events for patients undergoing percutaneous coronary intervention.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Thrombelastography; Thrombosis; Ticlopidine | 2012 |
[Effects of intensive antiplatelet therapy for patients with high on-treatment platelet reactivity after coronary stent implantation].
Topics: Acute Coronary Syndrome; Adult; Aged; Aspirin; Blood Platelets; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine | 2012 |
[High maintenance dose of clopidogrel improves long-term clinical outcomes in patients with elective percutaneous coronary intervention].
Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2012 |
Accelerated platelet inhibition by switching from atorvastatin to a non-CYP3A4-metabolized statin in patients with high platelet reactivity (ACCEL-STATIN) study.
Topics: Adenosine Diphosphate; Aspirin; Atorvastatin; Calcium Channel Blockers; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP3A; Drug Substitution; Drug Therapy, Combination; Female; Fluorobenzenes; Genotype; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Prospective Studies; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides; Ticlopidine | 2012 |
Pharmacokinetics and pharmacodynamics of ticagrelor in patients with stable coronary artery disease: results from the ONSET-OFFSET and RESPOND studies.
Topics: Adenosine; Aged; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Interactions; Female; Humans; Male; Middle Aged; Platelet Aggregation; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2012 |
Clinical features and racial/ethnic differences among the 3020 participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial.
Topics: Aged; Antihypertensive Agents; Aspirin; Black or African American; Blood Pressure; Chi-Square Distribution; Clopidogrel; Diabetes Mellitus; Drug Administration Schedule; Drug Therapy, Combination; Ethnicity; Female; Hispanic or Latino; Humans; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; North America; Platelet Aggregation Inhibitors; Prevalence; Racial Groups; Risk Factors; Secondary Prevention; Smoking; South America; Spain; Stroke; Ticlopidine; Time Factors; Treatment Outcome; White People | 2013 |
A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: results of the TRIGGER-PCI (Testing Platelet Reactivity
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2012 |
Risk of intracerebral hemorrhage in patients with cerebral microbleeds undergoing endovascular intervention.
Topics: Aged; Aged, 80 and over; Aspirin; Atherosclerosis; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Endovascular Procedures; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stroke; Ticlopidine | 2012 |
Thrombelastographic haemostatic status and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): assessing and monitoring the antithrombotic effect of clopidogrel and aspirin versus aspirin alone in hypercoagulable patients: study pr
Topics: Aspirin; Clinical Protocols; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Prospective Studies; Thrombelastography; Thromboembolism; Thrombophilia; Ticlopidine | 2012 |
Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Endoscopy, Gastrointestinal; Female; Gastric Mucosa; Genotype; Humans; Male; Peptic Ulcer; Rabeprazole; Severity of Illness Index; Ticlopidine; Treatment Outcome; Young Adult | 2012 |
Baseline Q waves as a prognostic modulator in patients with ST-segment elevation: insights from the PLATO trial.
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty, Balloon, Coronary; Biomarkers; Clopidogrel; Creatine Kinase, MB Form; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Prognosis; Prospective Studies; Purinergic P2Y Receptor Antagonists; Survival Analysis; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Troponin I; Troponin T | 2012 |
Combination therapy with warfarin plus clopidogrel improves outcomes in femoropopliteal bypass surgery patients.
Topics: Administration, Oral; Aged; Aspirin; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Comorbidity; Drug Therapy, Combination; Female; Femoral Artery; Graft Occlusion, Vascular; Humans; Logistic Models; Male; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Popliteal Artery; Proportional Hazards Models; Prospective Studies; Ticlopidine; Treatment Outcome; Vascular Patency; Warfarin | 2012 |
Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: exploration of a novel CYP2B6 phenotyping index.
Topics: Alkynes; Anti-HIV Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Clopidogrel; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 CYP2B6; Genotype; Humans; Hydroxylation; Itraconazole; Male; Oxidoreductases, N-Demethylating; Phenotype; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Lessons from platelet inhibition and patient outcomes.
Topics: Acute Coronary Syndrome; Adenosine; Blood Platelets; Clopidogrel; Confidence Intervals; Humans; Myocardial Infarction; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Statistics as Topic; Ticagrelor; Ticlopidine; United States | 2012 |
Pharmacodynamic effects of cangrelor and clopidogrel: the platelet function substudy from the cangrelor versus standard therapy to achieve optimal management of platelet inhibition (CHAMPION) trials.
Topics: Adenosine Monophosphate; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Antagonism; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Preoperative Care; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2012 |
Ticagrelor versus clopidogrel in patients with acute coronary syndromes and a history of stroke or transient ischemic attack.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Brain Ischemia; Clopidogrel; Female; Humans; Intracranial Hemorrhages; Ischemic Attack, Transient; Male; Middle Aged; Myocardial Infarction; Purinergic P2Y Receptor Antagonists; Risk Factors; Stroke; Ticagrelor; Ticlopidine | 2012 |
Rationale and design of the Cangrelor versus standard therapy to acHieve optimal Management of Platelet InhibitiON PHOENIX trial.
Topics: Adenosine Monophosphate; Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Assessment; Survival Analysis; Ticlopidine; Treatment Outcome | 2012 |
Impact of clopidogrel and aspirin treatment on the expression of proteins in platelets from type-2 diabetic patients with stable coronary ischemia.
Topics: Aged; Amino Acid Sequence; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Cytoskeletal Proteins; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gene Expression Regulation; Humans; Male; Molecular Sequence Data; Platelet Aggregation Inhibitors; Platelet Factor 4; Proteome; Ticlopidine | 2012 |
Pharmacokinetic and pharmacodynamic effects of elinogrel: results of the platelet function substudy from the intravenous and oral administration of elinogrel to evaluate tolerability and efficacy in nonurgent percutaneous coronary intervention patients (I
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Canada; Clopidogrel; Double-Blind Method; Drug Administration Schedule; Europe; Female; Heart Diseases; Humans; Injections, Intravenous; Male; Middle Aged; Models, Statistical; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Quinazolinones; Receptors, Purinergic P2Y12; Sulfonamides; Ticlopidine; Treatment Outcome; United States | 2012 |
Polyunsaturated omega-3 fatty acids improve responsiveness to clopidogrel after percutaneous coronary intervention in patients with cytochrome P450 2C19 loss-of-function polymorphism.
Topics: Administration, Cutaneous; Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Synergism; Fatty Acids, Omega-3; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Ticlopidine | 2012 |
Influence of genetic polymorphisms on the effect of high- and standard-dose clopidogrel after percutaneous coronary intervention: the GIFT (Genotype Information and Functional Testing) study.
Topics: Acute Coronary Syndrome; Alleles; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Genotype; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Prospective Studies; Ticlopidine; Treatment Outcome | 2012 |
Impact of high post-loading platelet aggregation on 30-day clinical outcomes after primary percutaneous coronary intervention. The antiplatelet regimen tailoring after primary PCI (ART-PCI) trial.
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Single-Blind Method; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: risk-adjusted retrospective data analysis.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Cause of Death; Chest Tubes; Clopidogrel; Cohort Studies; Combined Modality Therapy; Coronary Artery Bypass; Drug Administration Schedule; Drug Therapy, Combination; Erythrocyte Transfusion; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Recurrence; Retrospective Studies; Risk Adjustment; Thiophenes; Ticlopidine | 2012 |
Clopidogrel plus indobufen in acute coronary syndrome patients with hypersensitivity to aspirin undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Drug Hypersensitivity; Drug Therapy, Combination; Female; Humans; Isoindoles; Male; Middle Aged; Percutaneous Coronary Intervention; Phenylbutyrates; Platelet Aggregation Inhibitors; Risk Factors; Thromboxane B2; Ticlopidine; Treatment Outcome | 2013 |
A randomized, double-blind, active-controlled phase 2 trial to evaluate a novel selective and reversible intravenous and oral P2Y12 inhibitor elinogrel versus clopidogrel in patients undergoing nonurgent percutaneous coronary intervention: the INNOVATE-PC
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Canada; Clopidogrel; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Europe; Female; Heart Diseases; Hemorrhage; Humans; Injections, Intravenous; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Quinazolinones; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Stroke; Sulfonamides; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; United States | 2012 |
Personalized antiplatelet treatment after percutaneous coronary intervention: the MADONNA study.
Topics: Aged; Aged, 80 and over; Clopidogrel; Cohort Studies; Electrodes, Implanted; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Precision Medicine; Prospective Studies; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Effects of pantoprazole on dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Angina, Stable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2012 |
Predictors of high on-treatment platelet reactivity early after clopidogrel loading in ST-elevation myocardial infarction.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Pantoprazole; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Receptors, Purinergic P2Y12; Ticlopidine | 2012 |
Effect of a multifaceted intervention on use of evidence-based therapies in patients with acute coronary syndromes in Brazil: the BRIDGE-ACS randomized trial.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Aspirin; Brazil; Case Management; Checklist; Clopidogrel; Developing Countries; Education, Medical, Continuing; Evidence-Based Practice; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Quality Improvement; Reminder Systems; Single-Blind Method; Ticlopidine; Urban Population | 2012 |
Effects of cilostazol on cognition and regional cerebral blood flow in patients with Alzheimer's disease and cerebrovascular disease: a pilot study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aspirin; Cerebrovascular Circulation; Cerebrovascular Disorders; Cilostazol; Clopidogrel; Cognition; Female; Humans; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; Prospective Studies; Statistics, Nonparametric; Tetrazoles; Ticlopidine; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Treatment Outcome | 2013 |
Prognostic value of a high on-clopidogrel treatment platelet reactivity in bivalirudin versus abciximab treated non-ST-segment elevation myocardial infarction patients. ISAR-REACT 4 (Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action fo
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Clopidogrel; Cohort Studies; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Female; Heparin; Hirudins; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Recombinant Proteins; Signal Processing, Computer-Assisted; Stents; Survival Analysis; Ticlopidine | 2012 |
Efficacy and safety of clopidogrel in children with diarrhea associated hemolytic uremic syndrome.
Topics: Adolescent; Child; Child, Preschool; Clopidogrel; Diarrhea; Female; Hemolytic-Uremic Syndrome; Humans; Infant; Male; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2012 |
Clopidogrel trial in patients with elective percutaneous coronary intervention for stable angina and old myocardial infarction (CLEAN).
Topics: Adult; Aged; Angina, Stable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Treatment Outcome; Young Adult | 2012 |
Recovery of platelet function after discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated patients with stable coronary disease: the recovery trial.
Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Blood Platelets; Clopidogrel; Confounding Factors, Epidemiologic; Coronary Disease; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2012 |
P2Y12 platelet reactivity after thrombolytic therapy for ST-segment elevation myocardial infarction.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2012 |
Drug-drug interaction of rabeprazole and clopidogrel in healthy Chinese volunteers.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Rabeprazole; Ticlopidine | 2013 |
Cost-effectiveness of treating acute coronary syndrome patients with ticagrelor for 12 months: results from the PLATO study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Cost-Benefit Analysis; Female; Humans; Life Expectancy; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Antiplatelet effect of 600- and 300-mg loading doses of clopidogrel in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an analysis of the ARMYDA-6 MI (Antiplatelet therapy for Reduction of MYo
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Humans; Internationality; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Ticlopidine; Treatment Outcome | 2012 |
Pantoprazole significantly interferes with antiplatelet effect of clopidogrel: results of a pilot randomized trial.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Myocardial Infarction; Pantoprazole; Pilot Projects; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Ticlopidine | 2013 |
Effects of pioglitazone on platelet P2Y12-mediated signalling in clopidogrel-treated patients with type 2 diabetes mellitus.
Topics: Aged; Aspirin; Clopidogrel; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Interactions; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Pioglitazone; Platelet Aggregation; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Thiazolidinediones; Ticlopidine | 2012 |
Pharmacokinetic and pharmacodynamic effects of comedication of clopidogrel and dabigatran etexilate in healthy male volunteers.
Topics: Adult; Analysis of Variance; Antithrombins; Area Under Curve; Benzimidazoles; Biological Availability; Bleeding Time; Blood Coagulation; Clopidogrel; Cross-Over Studies; Dabigatran; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Germany; Humans; Male; Metabolic Clearance Rate; Partial Thromboplastin Time; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Thrombin Time; Ticlopidine; Young Adult | 2013 |
Triple vs. dual antiplatelet therapy in patients with acute myocardial infarction and renal dysfunction.
Topics: Aged; Aged, 80 and over; Aspirin; Cilostazol; Clopidogrel; Disease-Free Survival; Drug Therapy, Combination; Female; Humans; Kidney Diseases; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Survival Rate; Tetrazoles; Ticlopidine | 2012 |
Effect of cytochrome P450 2C19 polymorphism on target lesion outcome after drug-eluting stent implantation in japanese patients receiving clopidogrel.
Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Coronary Angiography; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Japan; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2012 |
Ticagrelor versus prasugrel in acute coronary syndrome patients with high on-clopidogrel platelet reactivity following percutaneous coronary intervention: a pharmacodynamic study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Cross-Over Studies; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Usefulness of the VerifyNow P2Y12 assay to evaluate the antiplatelet effects of ticagrelor and clopidogrel therapies.
Topics: Adenosine; Aged; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2012 |
Relation between clopidogrel active metabolite levels and different platelet aggregation methods in patients receiving clopidogrel and aspirin.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prodrugs; Ticlopidine; Time Factors | 2012 |
Angioplasty and stent treatment of transplant renal artery stenosis.
Topics: Adult; Aged; Angioplasty; Anticoagulants; Aspirin; Clopidogrel; Female; Follow-Up Studies; Humans; Hypertension, Renovascular; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Prospective Studies; Renal Artery Obstruction; Risk Factors; Stents; Ticlopidine; Treatment Outcome; Ultrasonography | 2012 |
The impact of CYP3A5*1/*3, PIA1/A2 and T744C polymorphisms on clopidogrel and acetylsalicylic acid response variability in Mexican population.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Comorbidity; Cytochrome P-450 CYP3A; Drug Resistance; Female; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Mexico; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Single Nucleotide; Prevalence; Receptors, Purinergic P2Y12; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
The impact of smoking on the antiplatelet action of clopidogrel in non-ST-elevation myocardial infarction patients: results from the ISAR-REACT 4 platelet substudy.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Germany; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Smoking; Stents; Ticlopidine; Treatment Outcome | 2012 |
Perioperative assessment of platelet function by Thromboelastograph Platelet Mapping in cardiovascular patients undergoing non-cardiac surgery.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Perioperative Care; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombelastography; Ticlopidine | 2013 |
Angiographic and platelet reactivity outcomes with prasugrel 60 mg pretreatment and clopidogrel 600 mg pretreatment in primary percutaneous coronary intervention.
Topics: Adult; Aged; Asian People; Clopidogrel; Cohort Studies; Coronary Thrombosis; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Preoperative Care; Singapore; Thiophenes; Ticlopidine | 2012 |
Influence of omeprazole and famotidine on the antiplatelet effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes: a prospective, randomized, multicenter study.
Topics: Acute Coronary Syndrome; Aged; Anti-Ulcer Agents; Aspirin; Blood Platelets; Clopidogrel; Drug Antagonism; Famotidine; Female; Humans; Male; Middle Aged; Myocardial Infarction; Omeprazole; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2012 |
The effectiveness of dual antiplatelet treatment in acute ischemic stroke patients with intracranial arterial stenosis: a subgroup analysis of CLAIR study.
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Constriction, Pathologic; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2013 |
Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial [NCT01159639].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Bypass; Croatia; Drug Resistance; Drug Therapy, Combination; Hemorrhage; Humans; Patient Readmission; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Research Design; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Stroke; Thiophenes; Ticlopidine | 2012 |
Prasugrel versus high dose clopidogrel to overcome early high on clopidogrel platelet reactivity in patients with ST elevation myocardial infarction.
Topics: Aged; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2012 |
Effects of clopidogrel added to aspirin in patients with recent lacunar stroke.
Topics: Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Stroke; Stroke, Lacunar; Ticlopidine | 2012 |
Impact of Clopidogrel loading dose in patients with chronic kidney disease undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Preoperative Care; Prognosis; Renal Insufficiency, Chronic; Republic of Korea; Retrospective Studies; Risk Factors; Stents; Survival Rate; Ticlopidine | 2012 |
Aspirin plus clopidogrel for optimal platelet inhibition following off-pump coronary artery bypass surgery: results from the CRYSSA (prevention of Coronary arteRY bypaSS occlusion After off-pump procedures) randomised study.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass, Off-Pump; Coronary Occlusion; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2012 |
Tranexamic Acid in on-pump coronary artery bypass grafting without clopidogrel and aspirin cessation: randomized trial and 1-year follow-up.
Topics: Antifibrinolytic Agents; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors; Tranexamic Acid; Treatment Outcome | 2013 |
Prior smoking status, clinical outcomes, and the comparison of ticagrelor with clopidogrel in acute coronary syndromes-insights from the PLATelet inhibition and patient Outcomes (PLATO) trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Smoking; Stents; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Microvascular effect of intracoronary eptifibatide in acute myocardial infarction.
Topics: Adolescent; Adult; Clopidogrel; Coronary Angiography; Echocardiography; Electrocardiography; Eptifibatide; Female; Humans; Male; Microcirculation; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Peptides; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Thrombosis; Ticlopidine; Treatment Outcome; Young Adult | 2012 |
Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the prospective randomized PLATelet inhibition and patient Outcomes (PLATO) trial.
Topics: Acute Coronary Syndrome; Adenosine; Age Factors; Aged; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Patient Safety; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Stents; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
High on-treatment platelet reactivity on commonly prescribed antiplatelet agents following transient ischaemic attack or ischaemic stroke: results from the Trinity Antiplatelet Responsiveness (TRAP) study.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Cross-Over Studies; Female; Humans; Ischemic Attack, Transient; Leukocytes; Male; Middle Aged; P-Selectin; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Tetraspanin 30; Ticlopidine | 2013 |
Influence of CYP2C19 loss-of-function variants on the antiplatelet effects and cardiovascular events in clopidogrel-treated Chinese patients undergoing percutaneous coronary intervention.
Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Asian People; China; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; DNA; Female; Genotype; Heart Diseases; Humans; Linear Models; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stents; Ticlopidine; Young Adult | 2013 |
Thrombus and antiplatelet therapy in type 2 diabetes mellitus. A prospective study after non-ST elevation acute coronary syndrome and a randomised, blinded, placebo-controlled study in stable angina.
Topics: Acute Coronary Syndrome; Aged; Angina, Stable; Aspirin; Clopidogrel; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Thrombosis; Ticlopidine | 2012 |
The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Kaplan-Meier Estimate; Male; Platelet Aggregation Inhibitors; Risk Assessment; Severity of Illness Index; Stroke; Thromboembolism; Ticlopidine | 2013 |
Clopidogrel two doses comparative 1-year assessment of safety and efficacy (COMPASS) study in Japanese patients with ischemic stroke.
Topics: Age Factors; Aged; Asian People; Body Weight; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Japan; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2012 |
Factors contributing to the lower mortality with ticagrelor compared with clopidogrel in patients undergoing coronary artery bypass surgery.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Coronary Artery Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Europe; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Comparative pharmacokinetics/pharmacodynamics of clopidogrel besylate and clopidogrel bisulfate in healthy Korean subjects.
Topics: Adult; Area Under Curve; Bleeding Time; Clopidogrel; Cross-Over Studies; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Republic of Korea; Salts; Ticlopidine; Young Adult | 2012 |
The influence of omeprazole on platelet inhibition of clopidogrel in various CYP2C19 mutant alleles.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Male; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2012 |
Pharmacodynamic effect of switching therapy in patients with high on-treatment platelet reactivity and genotype variation with high clopidogrel Dose versus prasugrel: the RESET GENE trial.
Topics: Aged; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Substitution; Female; Genotype; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Phenotype; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Rome; Thiophenes; Ticlopidine; Treatment Outcome | 2012 |
Lack of association between clopidogrel responsiveness tested using point-of-care assay and prognosis of patients with coronary artery disease.
Topics: Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prospective Studies; Stroke; Survival Rate; Ticlopidine | 2013 |
Biological efficacy of twice daily aspirin in type 2 diabetic patients with coronary artery disease.
Topics: Analysis of Variance; Arachidonic Acid; Aspirin; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Administration Schedule; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2012 |
Comparing ticagrelor versus clopidogrel in patients with a history of cerebrovascular disease: a net clinical harm?
Topics: Adenosine; Cerebrovascular Disorders; Clopidogrel; Humans; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2012 |
[Acute non ST-elevation coronary syndrome in real practice of hospitals in Russia. Comparative data from RECORD 2 and RECORD registries].
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Coronary Angiography; Electrocardiography; Female; Follow-Up Studies; Heparin, Low-Molecular-Weight; Hospital Mortality; Hospitals; Humans; Incidence; Injections, Subcutaneous; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Russia; Survival Rate; Ticlopidine; Treatment Outcome; Young Adult | 2012 |
Randomized comparison of new dual-antiplatelet therapy (aspirin, prasugrel) and triple-antiplatelet therapy (aspirin, clopidogrel, cilostazol) using P2Y12 point-of-care assay in patients with STEMI undergoing primary PCI.
Topics: Adult; Aged; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prasugrel Hydrochloride; Prospective Studies; Receptors, Purinergic P2Y12; Tetrazoles; Thiophenes; Ticlopidine | 2013 |
Randomized controlled trial of symptomatic middle cerebral artery stenosis: endovascular versus medical therapy in a Chinese population.
Topics: Adult; Aged; Angioplasty; Asian People; Aspirin; Clopidogrel; Diabetes Mellitus; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hyperlipidemias; Hypertension; Infarction, Middle Cerebral Artery; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Secondary Prevention; Stents; Ticlopidine; Treatment Outcome | 2012 |
Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudy.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Angina, Unstable; Aspirin; Body Weight; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Myocardial Ischemia; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Stroke; Thiophenes; Ticlopidine; Treatment Outcome | 2012 |
Effect of amlodipine on platelet inhibition by clopidogrel in patients with ischaemic heart disease: a randomised, controlled trial.
Topics: Aged; Aged, 80 and over; Amlodipine; Calcium Channel Blockers; Chi-Square Distribution; Clopidogrel; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Female; Hong Kong; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Ticlopidine; Time Factors | 2013 |
Bedside monitoring to adjust antiplatelet therapy for coronary stenting.
Topics: Aged; Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Monitoring; Female; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prasugrel Hydrochloride; Pyridines; Retreatment; Stents; Thiophenes; Ticlopidine | 2012 |
Outcome and causes of renal deterioration evaluated by serial cystatin C measurements in acute coronary syndrome patients -- results from the PLATelet inhibition and patient Outcomes (PLATO) study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Analysis of Variance; Biomarkers; Clopidogrel; Cystatin C; Female; Humans; Kidney; Kidney Function Tests; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
High versus standard clopidogrel loading in patients undergoing carotid artery stenting prior to cardiac surgery to assess the number of microemboli detected with transcranial Doppler: results of the randomized IMPACT trial.
Topics: Aged; Cardiac Surgical Procedures; Carotid Stenosis; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug-Eluting Stents; Female; Follow-Up Studies; Heart Diseases; Humans; Intracranial Embolism; Ischemic Attack, Transient; Male; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2013 |
What is better antiplatelet agent to prevent recurrent stroke?
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Benzimidazoles; Benzoates; Brain Ischemia; Clopidogrel; Dipyridamole; Double-Blind Method; Evidence-Based Medicine; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Telmisartan; Ticlopidine; Treatment Outcome | 2012 |
[Clinical application of VerifyNow-P2Y12 assay in evaluation of platelet inhibition efficacy of clopidogrel].
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Purinergic P2Y12; Ticlopidine | 2012 |
Impact of renal function on clopidogrel-induced antiplatelet effects in coronary artery disease patients without diabetes mellitus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2013 |
Effect of the CYP2C19 2 and 3 genotypes, ABCB1 C3435T and PON1 Q192R alleles on the pharmacodynamics and adverse clinical events of clopidogrel in Chinese people after percutaneous coronary intervention.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Asian People; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Registries; Ticlopidine | 2013 |
[A prospective randomized control clinical trial about clopidogrel combined with warfarin versus clopidogrel alone in the prevention of restenosis after femoral-popliteal artery angioplasty].
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Arterial Occlusive Diseases; Clopidogrel; Female; Femoral Artery; Humans; Male; Middle Aged; Popliteal Artery; Postoperative Complications; Prospective Studies; Ticlopidine; Warfarin | 2012 |
A randomized comparison of platelet reactivity in patients after treatment with various commercial clopidogrel preparations: the CLO-CLO trial.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Clopidogrel; Cross-Over Studies; Drugs, Generic; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Patient Selection; Percutaneous Coronary Intervention; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Single-Blind Method; Stents; Therapeutic Equivalency; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Optimized duration of clopidogrel therapy following treatment with the Endeavor zotarolimus-eluting stent in real-world clinical practice (OPTIMIZE) trial: rationale and design of a large-scale, randomized, multicenter study.
Topics: Adult; Aspirin; Brazil; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Period; Prospective Studies; Research Design; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2012 |
Benefit of long-term dual anti-platelet therapy in patients treated with drug-eluting stents: from the NHLBI dynamic registry.
Topics: Antineoplastic Agents, Phytogenic; Aspirin; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Follow-Up Studies; Humans; Immunosuppressive Agents; Paclitaxel; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recurrence; Registries; Retrospective Studies; Sirolimus; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome; United States | 2013 |
Selecting antiplatelet therapy at the time of percutaneous intervention for an acute coronary syndrome: weighing the benefits and risks of prasugrel versus clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Models, Statistical; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Risk Factors; Stroke; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin.
Topics: Administration, Oral; Adolescent; Adult; Aspirin; Clopidogrel; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Tablets, Enteric-Coated; Ticlopidine; Treatment Outcome; Young Adult | 2013 |
Increased platelet aggregation and turnover in the acute phase of ST-elevation myocardial infarction.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine | 2013 |
Decrease in high on-treatment platelet reactivity (HPR) prevalence on switching from clopidogrel to prasugrel: insights from the switching anti-platelet (SWAP) study.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Substitution; Female; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Pharmacogenetics; Phenotype; Phosphoproteins; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Adjunctive cilostazol versus high maintenance dose of clopidogrel in patients with hyporesponsiveness to chronic clopidogrel therapy.
Topics: Adult; Aged; Blood Platelets; Cilostazol; Clopidogrel; Cross-Over Studies; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Receptors, Purinergic P2Y12; Tetrazoles; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
A randomized crossover study comparing the antiplatelet effect of plavix versus generic clopidogrel.
Topics: Adenosine Diphosphate; Adult; Clopidogrel; Cross-Over Studies; Drugs, Generic; England; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Therapeutic Equivalency; Thrombelastography; Ticlopidine; Time Factors | 2012 |
Pharmacodynamic effect of prasugrel 5 mg vs clopidogrel 150 mg in elderly patients with high on-clopidogrel platelet reactivity.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Efficacy and safety of low-dose clopidogrel in Japanese patients after drug-eluting stent implantation: a randomized pilot trial.
Topics: Aged; Asian People; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Japan; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Interventional | 2014 |
Clopidogrel hyper-response and bleeding risk in neurointerventional procedures.
Topics: Adult; Aged; Anticoagulants; Blood Platelets; Cerebral Arteries; Cerebral Hemorrhage; Clopidogrel; Dose-Response Relationship, Drug; Endovascular Procedures; Female; Heparin; Humans; Incidence; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Ticlopidine | 2013 |
Reduction in first and recurrent cardiovascular events with ticagrelor compared with clopidogrel in the PLATO Study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Secondary Prevention; Severity of Illness Index; Stroke; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Increased local cytokine production at culprit superficial femoral artery plaques.
Topics: Aspirin; CD40 Ligand; Clopidogrel; Constriction, Pathologic; Female; Femoral Artery; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Lower Extremity; Lymphotoxin-alpha; Male; Middle Aged; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2013 |
Should duration of dual antiplatelet therapy depend on the type and/or potency of implanted stent? A pre-specified analysis from the PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia studY (PRODIGY).
Topics: Aged; Clopidogrel; Coronary Restenosis; Coronary Vessels; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Everolimus; Female; Graft Occlusion, Vascular; Humans; Hyperplasia; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Sirolimus; Stents; Stroke; Ticlopidine; Tunica Intima | 2013 |
Percutaneous left atrial appendage closure for stroke prophylaxis in patients with atrial fibrillation: 2.3-Year Follow-up of the PROTECT AF (Watchman Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation) Trial.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Embolism; Female; Follow-Up Studies; Humans; Male; Prostheses and Implants; Stroke; Ticlopidine; Treatment Outcome; Warfarin | 2013 |
Comparison of antiplatelet efficacy and tolerability of clopidogrel napadisilate with clopidogrel bisulfate in coronary artery disease patients after percutaneous coronary intervention: a prospective, multicenter, randomized, open-label, phase IV, noninfe
Topics: Aged; Blood Platelets; Cerebrovascular Disorders; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Republic of Korea; Therapeutic Equivalency; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Clopidogrel pharmacokinetics and pharmacodynamics vary widely despite exclusion or control of polymorphisms (CYP2C19, ABCB1, PON1), noncompliance, diet, smoking, co-medications (including proton pump inhibitors), and pre-existent variability in platelet f
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Coagulation; Cardiovascular Diseases; Clopidogrel; Confounding Factors, Epidemiologic; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Proton Pump Inhibitors; Smoking; Ticlopidine | 2013 |
Clopidogrel added to aspirin adds no benefit but bleeding risk in patients with recent lacunar stroke.
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Stroke, Lacunar; Ticlopidine | 2013 |
Paraoxonase-1 Q192R polymorphism is not associated with clopidogrel response in Chinese stroke patients.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Aryldialkylphosphatase; Asian People; Clopidogrel; Female; Genotype; Humans; Linear Models; Male; Mass Spectrometry; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stroke; Ticlopidine; Young Adult | 2012 |
Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel.
Topics: Administration, Oral; Adult; Aspirin; Clopidogrel; Coronary Thrombosis; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Follow-Up Studies; Gastrointestinal Diseases; Humans; Middle Aged; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Ticlopidine; Treatment Outcome | 2013 |
Efficacy and safety of triple antiplatelet therapy in obese patients undergoing stent implantation.
Topics: Adult; Aged; Aspirin; Blood Platelets; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Obesity; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Implantation; Stents; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Pharmacodynamic comparisons for single loading doses of prasugrel (30 mg) and clopidogrel (600 mg) in healthy Korean volunteers.
Topics: Adult; Analysis of Variance; Asian People; Clopidogrel; Cross-Over Studies; Humans; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Republic of Korea; Thiophenes; Ticlopidine; Time Factors; Young Adult | 2013 |
Rationale and design of the on-treatment PLAtelet Reactivity-Guided Therapy Modification FOR ST-Segment Elevation Myocardial Infarction (PLATFORM) randomized trial.
Topics: Adenosine; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Different effects of clopidogrel and clarithromycin on the enantioselective pharmacokinetics of sibutramine and its active metabolites in healthy subjects.
Topics: Adult; Appetite Depressants; Aryl Hydrocarbon Hydroxylases; Clarithromycin; Clopidogrel; Cross-Over Studies; Cyclobutanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Genotype; Humans; Male; Microsomes; Oxidoreductases, N-Demethylating; Polymorphism, Genetic; Stereoisomerism; Ticlopidine; Young Adult | 2013 |
Comparison of original and generic clopidogrel 600 mg loading dose in the patients who planned undergoing coronary angiography.
Topics: Adenosine Diphosphate; Clopidogrel; Coronary Angiography; Drugs, Generic; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2012 |
Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.
Topics: Adult; Aged; Alleles; Chromosomes, Human, Pair 1; Clopidogrel; Cohort Studies; Coronary Artery Disease; Female; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Ticlopidine | 2013 |
Investigation of drug-drug interactions between clopidogrel and fluoxetine.
Topics: Adenosine Diphosphate; Adult; Area Under Curve; Cell Adhesion Molecules; Clopidogrel; Cross-Over Studies; Drug Interactions; Flow Cytometry; Fluoxetine; Humans; Male; Microfilament Proteins; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Selective Serotonin Reuptake Inhibitors; Ticlopidine; Young Adult | 2013 |
Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting: a multicenter randomized trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug Interactions; Female; Humans; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Tranexamic Acid; Young Adult | 2013 |
High-dose atorvastatin on the pharmacodynamic effects of double-dose clopidogrel in patients undergoing percutaneous coronary interventions: The ACHIDO (Atorvastatin and Clopidogrel HIgh DOse in stable patients with residual high platelet activity) study.
Topics: Age Factors; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Atorvastatin; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Resistance; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Italy; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Pyrroles; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Relationship of CYP2C19*2 and CYP2C19*3 gene polymorphism with clopidogrel response variability and recurrent cardiovascular events in Chinese patients undergoing percutaneous coronary intervention.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Asian People; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2013 |
Efficacy and safety of 12 versus 48 months of dual antiplatelet therapy after implantation of a drug-eluting stent: the OPTImal DUAL antiplatelet therapy (OPTIDUAL) trial: study protocol for a randomized controlled trial.
Topics: Aspirin; Clinical Protocols; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; France; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Research Design; Stroke; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Telephone contact to improve adherence to dual antiplatelet therapy after drug-eluting stent implantation.
Topics: Aged; Aspirin; Clopidogrel; Coronary Thrombosis; Counseling; Drug Prescriptions; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Linear Models; Male; Medication Adherence; Middle Aged; Multivariate Analysis; Patient Discharge; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Quebec; Self Report; Telephone; Tertiary Care Centers; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Addition of cilostazol to conventional dual antiplatelet therapy reduces the risk of cardiac events and restenosis after drug-eluting stent implantation: a meta-analysis.
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Heart Diseases; Humans; Male; Middle Aged; Myocardial Revascularization; Odds Ratio; Platelet Aggregation Inhibitors; Risk; Tetrazoles; Ticlopidine | 2013 |
Quantification of the effect of clopidogrel on enzymatic infarct size related to a percutaneous coronary intervention in patients with acute coronary syndromes: insights from the CHAMPION percutaneous coronary intervention trial.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Creatine Kinase, MB Form; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Severity of Illness Index; Ticlopidine | 2013 |
Comparison of prasugrel and clopidogrel reloading on high platelet reactivity in clopidogrel-loaded patients undergoing percutaneous coronary intervention (PRAISE-HPR): a study protocol for a prospective randomized controlled clinical trial.
Topics: Blood Platelets; Clinical Protocols; Clopidogrel; Drug Administration Schedule; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Republic of Korea; Research Design; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
St. John's Wort in patients non-responders to clopidogrel undergoing percutaneous coronary intervention: a single-center randomized open-label trial (St. John's Trial).
Topics: Aged; Analysis of Variance; Belgium; Blood Platelets; Chi-Square Distribution; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Hypericum; Male; Middle Aged; Percutaneous Coronary Intervention; Phytotherapy; Plant Extracts; Plants, Medicinal; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Population pharmacokinetic analysis of clopidogrel in healthy Jordanian subjects with emphasis optimal sampling strategy.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Clopidogrel; Humans; Jordan; Male; Middle Aged; Models, Biological; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Young Adult | 2013 |
Relationship between CYP2C19 loss-of-function polymorphism and platelet reactivities with clopidogrel treatment in Japanese patients undergoing coronary stent implantation.
Topics: Aryl Hydrocarbon Hydroxylases; Asian People; Cell Adhesion Molecules; Clopidogrel; Coronary Vessels; Cytochrome P-450 CYP2C19; Humans; Japan; Microfilament Proteins; Myocardial Ischemia; P-Selectin; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Prospective Studies; Stents; Ticlopidine | 2013 |
Effect of platelet inhibition with cangrelor during PCI on ischemic events.
Topics: Adenosine Monophosphate; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Humans; Intention to Treat Analysis; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2013 |
Fibrinolysis or primary PCI in ST-segment elevation myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Electrocardiography; Enoxaparin; Female; Fibrinolytic Agents; Heart Failure; Humans; Intracranial Hemorrhages; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Tenecteplase; Thrombolytic Therapy; Ticlopidine; Time-to-Treatment; Tissue Plasminogen Activator | 2013 |
Cost-effectiveness of ticagrelor versus clopidogrel for the prevention of atherothrombotic events in adult patients with acute coronary syndrome in Germany.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Atherosclerosis; Clopidogrel; Cost-Benefit Analysis; Decision Trees; Double-Blind Method; Drugs, Generic; Follow-Up Studies; Germany; Humans; Markov Chains; Models, Economic; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Quality-Adjusted Life Years; Thrombosis; Ticagrelor; Ticlopidine; Time Factors | 2013 |
Ticlopidine with Ginkgo Biloba extract: a feasible combination for patients with acute cerebral ischemia.
Topics: Acute Disease; Alleles; Aryl Hydrocarbon Hydroxylases; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Ginkgo biloba; Humans; Male; Middle Aged; Pilot Projects; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2013 |
Assessing patient-reported outcomes and preferences for same-day discharge after percutaneous coronary intervention: results from a pilot randomized, controlled trial.
Topics: Academic Medical Centers; Adaptation, Psychological; Chi-Square Distribution; Clopidogrel; Emergency Service, Hospital; Female; Humans; Length of Stay; Male; Medication Adherence; Middle Aged; New York City; Office Visits; Outcome and Process Assessment, Health Care; Patient Discharge; Patient Preference; Patient Readmission; Percutaneous Coronary Intervention; Pilot Projects; Platelet Aggregation Inhibitors; Surveys and Questionnaires; Texas; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Dual antiplatelets reduce microembolic signals in patients with transient ischemic attack and minor stroke: subgroup analysis of CLAIR study.
Topics: Adult; Aged; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Intracranial Embolism; Ischemic Attack, Transient; Male; Middle Aged; Molecular Sequence Data; Platelet Aggregation Inhibitors; Regression Analysis; Retrospective Studies; Severity of Illness Index; Stroke; Ticlopidine; Time Factors; Ultrasonography, Doppler, Transcranial | 2014 |
Strategies of clopidogrel load and atorvastatin reload to prevent ischemic cerebral events in patients undergoing protected carotid stenting. Results of the randomized ARMYDA-9 CAROTID (Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting
Topics: Aged; Angioplasty, Balloon; Anticholesteremic Agents; Atorvastatin; Brain Ischemia; Carotid Artery Diseases; Carotid Stenosis; Clopidogrel; Diffusion Magnetic Resonance Imaging; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Male; Platelet Aggregation Inhibitors; Pyrroles; Research Design; Stents; Ticlopidine; Treatment Outcome | 2013 |
Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with diabetes.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Single-Blind Method; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Decreased platelet miR-223 expression is associated with high on-clopidogrel platelet reactivity.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Disease; Down-Regulation; Female; Humans; Male; MicroRNAs; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2013 |
Cilostazol reduces periprocedural hemodynamic depression in carotid artery stenting.
Topics: Aged; Angioplasty; Bradycardia; Carotid Stenosis; Cilostazol; Clopidogrel; Female; Humans; Hypotension; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Tetrazoles; Ticlopidine | 2013 |
Anterior chamber bleeding after laser peripheral iridotomy.
Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Anticoagulants; Aspirin; Clopidogrel; Eye Color; Female; Glaucoma, Angle-Closure; Gonioscopy; Humans; Hyphema; Incidence; Intraocular Pressure; Iridectomy; Iris; Laser Therapy; Lasers, Solid-State; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Risk Factors; Ticlopidine; Tonometry, Ocular; Warfarin | 2013 |
A prospective randomized controlled clinical trial on clopidogrel combined with warfarin versus clopidogrel alone in the prevention of restenosis after endovascular treatment of the femoropopliteal artery.
Topics: Aged; Anticoagulants; Clopidogrel; Constriction, Pathologic; Drug Therapy, Combination; Endovascular Procedures; Female; Femoral Artery; Humans; Ischemia; Male; Perioperative Care; Platelet Aggregation Inhibitors; Popliteal Artery; Recurrence; Ticlopidine; Warfarin | 2013 |
Relationship between postoperative clopidogrel use and subsequent angiographic and clinical outcomes following coronary artery bypass grafting.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Care; Ticlopidine | 2013 |
Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Secondary Prevention; Stroke; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Left atrial appendage closure with the Watchman device in patients with a contraindication for oral anticoagulation: the ASAP study (ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology).
Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Atrial Appendage; Clopidogrel; Contraindications; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2013 |
Efficacy of clopidogrel reloading in patients with acute coronary syndrome undergoing percutaneous coronary intervention during chronic clopidogrel therapy (from the Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty [ARMYDA-8 RELO
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2013 |
The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Smoking; Thiophenes; Ticlopidine | 2013 |
Current medical management of stable coronary artery disease before and after elective percutaneous coronary intervention.
Topics: Adrenergic beta-Antagonists; Aged; Aspirin; Clopidogrel; Coloring Agents; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Care; Preoperative Care; Retrospective Studies; Severity of Illness Index; Ticlopidine; Treatment Outcome | 2013 |
Platelet inhibitory effect of clopidogrel in patients treated with omeprazole, pantoprazole, and famotidine: a prospective, randomized, crossover study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Aspirin; Chi-Square Distribution; Clopidogrel; Cross-Over Studies; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Famotidine; Female; Histamine H2 Antagonists; Humans; Israel; Linear Models; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Single-Blind Method; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
[Prevention of non-acute stent thrombosis after drug-eluting stent implantation].
Topics: Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Tirofiban; Tyrosine; Warfarin | 2013 |
Dual antiplatelet therapy clopidogrel with low-dose cilostazol intensifies platelet inhibition in patients with ischemic stroke.
Topics: Adenosine Diphosphate; Aged; Aryl Hydrocarbon Hydroxylases; Brain Ischemia; Cilostazol; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Risk Factors; Tetrazoles; Ticlopidine | 2013 |
Incidence and outcome of high on-treatment platelet reactivity in patients with non-ST elevation acute coronary syndromes undergoing percutaneous coronary intervention (from the VIP [VerifyNow and Inhibition of Platelet Reactivity] study).
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Angiography; Death, Sudden, Cardiac; Electrocardiography; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Italy; Male; Myocardial Infarction; Platelet Activation; Prognosis; Prospective Studies; Purinergic P2Y Receptor Antagonists; Stroke; Ticlopidine | 2013 |
Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: the GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients.
Topics: Administration, Oral; Age Factors; Aged; Aged, 80 and over; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Reference Values; Severity of Illness Index; Single-Blind Method; Survival Rate; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Clopidogrel in infants with systemic-to-pulmonary-artery shunts.
Topics: Anastomosis, Surgical; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Heart Defects, Congenital; Hemorrhage; Humans; Infant; Infant, Newborn; Kaplan-Meier Estimate; Male; Platelet Aggregation Inhibitors; Pulmonary Artery; Thrombosis; Ticlopidine | 2013 |
Platelet inhibition by abciximab bolus-only administration and oral ADP receptor antagonist loading in acute coronary syndrome patients: the blocking and bridging strategy.
Topics: Abciximab; Acute Coronary Syndrome; Administration, Oral; Adult; Aged; Antibodies, Monoclonal; Blood Platelets; Clopidogrel; Drug Administration Routes; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2013 |
Quantitative ST-depression in acute coronary syndromes: the PLATO electrocardiographic substudy.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Electrocardiography; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Prognosis; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Health-related quality of life of ticagrelor versus clopidogrel in patients with acute coronary syndromes-results from the PLATO trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Quality of Life; Surveys and Questionnaires; Ticagrelor; Ticlopidine; Time Factors | 2013 |
The effect of doubling the dose of acetylsalicylic acid (ASA) on platelet function parameters in patients with type 2 diabetes and platelet hyperreactivity during treatment with 75 mg of ASA: a subanalysis of the AVOCADO study.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Function Tests; Prospective Studies; Ticlopidine | 2013 |
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.
Topics: Aged; Aspirin; Clopidogrel; Disease-Free Survival; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Secondary Prevention; Stroke; Ticlopidine | 2013 |
Oral clopidogrel improves cutaneous microvascular function through EDHF-dependent mechanisms in middle-aged humans.
Topics: Administration, Oral; Analysis of Variance; Aspirin; Biological Factors; Blood Flow Velocity; Clopidogrel; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hyperemia; Laser-Doppler Flowmetry; Male; Microcirculation; Microdialysis; Microvessels; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Pennsylvania; Purinergic P2Y Receptor Antagonists; Regional Blood Flow; Skin; Skin Temperature; Ticlopidine; Time Factors; Vasodilation | 2013 |
Discontinuation of antiplatelet study medication and risk of recurrent stroke and cardiovascular events: results from the PRoFESS study.
Topics: Aged; Aged, 80 and over; Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Dipyridamole; Drug Combinations; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2013 |
Does high-density lipoprotein influence the development of saphenous vein graft disease after coronary bypass surgery?: exploratory analysis from the CASCADE trial.
Topics: Aged; Angiography; Clopidogrel; Coronary Artery Bypass; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Hyperplasia; Lipoproteins, HDL; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Period; Risk Assessment; Saphenous Vein; Ticlopidine; Tunica Intima | 2013 |
Personalized antiplatelet therapy according to CYP2C19 genotype after percutaneous coronary intervention: a randomized control trial.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine | 2013 |
Pharmacodynamic effects of adjunctive high dose atorvastatin on double dose clopidogrel in patients with high on-treatment platelet reactivity depending on diabetes mellitus status.
Topics: Aged; Atorvastatin; Clopidogrel; Diabetes Mellitus; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Pyrroles; Thrombosis; Ticlopidine | 2014 |
Elderly patients with acute coronary syndromes managed without revascularization: insights into the safety of long-term dual antiplatelet therapy with reduced-dose prasugrel versus standard-dose clopidogrel.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Disease Management; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hemorrhage; Humans; Longitudinal Studies; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Angiographic outcomes in the PLATO Trial (Platelet Inhibition and Patient Outcomes).
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Aged; Clopidogrel; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Coronary Thrombosis; Coronary Vessels; Double-Blind Method; Female; Humans; Logistic Models; Male; Middle Aged; Myocardial Perfusion Imaging; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Predictive Value of Tests; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
The pharmacokinetics and safety of a fixed-dose combination of acetylsalicylic acid and clopidogrel compared with the concurrent administration of acetylsalicylic acid and clopidogrel in healthy subjects: a randomized, open-label, 2-sequence, 2-period, si
Topics: Administration, Oral; Adult; Aspirin; Clopidogrel; Cross-Over Studies; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Healthy Volunteers; Humans; Male; Middle Aged; Ticlopidine; Young Adult | 2013 |
Platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trial: rationale and design.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Research Design; Stroke; Ticlopidine; Young Adult | 2013 |
Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study.
Topics: Aspirin; Blood Coagulation Tests; Clopidogrel; Coronary Disease; Coronary Stenosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prospective Studies; Registries; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Discontinuation of preoperative clopidogrel is unnecessary in peripheral arterial surgery.
Topics: Aged; Clopidogrel; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Preoperative Care; Prognosis; Prospective Studies; Ticlopidine; Vascular Surgical Procedures; Withholding Treatment | 2013 |
Short-term follow-up of tirofiban as alternative therapy for urgent surgery patients with an implanted coronary drug-eluting stent after ST-elevation myocardial infarction.
Topics: Aged; Aspirin; China; Clopidogrel; Drug Administration Schedule; Drug Substitution; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Risk Factors; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Tyrosine | 2013 |
Stent thrombosis with ticagrelor versus clopidogrel in patients with acute coronary syndromes: an analysis from the prospective, randomized PLATO trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Thrombosis; Double-Blind Method; Female; Follow-Up Studies; Heart Diseases; Humans; Internationality; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Stents; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
A randomized trial of platelet reactivity monitoring-adjusted clopidogrel therapy versus prasugrel therapy to reduce high on-treatment platelet reactivity.
Topics: Aged; Blood Platelets; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Single-Blind Method; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Comparison of antiplatelet effect and safety of clopidogrel napadisilate with clopidogrel bisulfate in coronary artery disease patients: multi-center, randomized, double-blind, phase IV, non-inferiority clinical trial.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Nervous System Diseases; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2013 |
Comparison of pre-hospital 600 mg or 900 mg vs. peri-interventional 300 mg clopidogrel in patients with ST-elevation myocardial infarction undergoing primary coronary angioplasty. The Load&Go randomized trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Electrocardiography; Emergency Medical Services; Female; Humans; Male; Middle Aged; Myocardial Infarction; Perioperative Care; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2013 |
Pharmacodynamic effects of EV-077 in patients with diabetes mellitus and coronary artery disease on aspirin or clopidogrel monotherapy: results of an in vitro pilot investigation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Ticlopidine | 2014 |
Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Clopidogrel; Coronary Angiography; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Stroke; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Effects of clopidogrel on the platelet activation response in horses.
Topics: Animals; Clopidogrel; Female; Flow Cytometry; Horses; Platelet Activation; Platelet Aggregation Inhibitors; Statistics, Nonparametric; Thrombelastography; Ticlopidine | 2013 |
Implementation of contemporary oral antiplatelet treatment guidelines in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a report from the GReek AntiPlatelet rEgistry (GRAPE).
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Aged; Clopidogrel; Combined Modality Therapy; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Practolol; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Enhanced active metabolite generation and platelet inhibition with prasugrel compared to clopidogrel regardless of genotype in thienopyridine metabolic pathways.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Blood Platelets; Cell Adhesion Molecules; Cells, Cultured; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Piperazines; Platelet Activation; Polymorphism, Genetic; Prasugrel Hydrochloride; Prospective Studies; Pyridines; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2013 |
CYP2C19 poor metabolizer is associated with clinical outcome of clopidogrel therapy in acute myocardial infarction but not stable angina.
Topics: Adult; Aged; Alleles; Angina, Stable; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Factors; Ticlopidine; Treatment Outcome | 2013 |
Correlates of saphenous vein graft hyperplasia and occlusion 1 year after coronary artery bypass grafting: analysis from the CASCADE randomized trial.
Topics: Aged; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Hyperplasia; Male; Middle Aged; Prospective Studies; Saphenous Vein; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Higher body weight patients on clopidogrel maintenance therapy have lower active metabolite concentrations, lower levels of platelet inhibition, and higher rates of poor responders than low body weight patients.
Topics: Adolescent; Adult; Aged; Blood Platelets; Body Weight; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Aggressive medical therapy alone is not adequate in certain patients with severe symptomatic carotid stenosis.
Topics: Aspirin; Atorvastatin; Carotid Artery Diseases; Clopidogrel; Constriction, Pathologic; Endovascular Procedures; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2013 |
Adjunctive cilostazol versus double-dose clopidogrel after drug-eluting stent implantation: the HOST-ASSURE randomized trial (Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis-Safety & Effectiveness of Drug-Eluting Stents & Anti-plate
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Prosthesis Design; Republic of Korea; Risk Factors; Stroke; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelet Disorders; Child; Clopidogrel; Female; Humans; Male; Mexico; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Syndrome; Thrombophilia; Thrombosis; Ticlopidine; Young Adult | 2015 |
Comparison of dual versus triple antiplatelet therapy after drug-eluting stent according to stent length (from the pooled analysis of DECLARE trials).
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Diabetes Complications; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Implantation; Tetrazoles; Ticlopidine; Treatment Outcome | 2013 |
Circadian variation of stent thrombosis and the effect of more robust platelet inhibition: a post hoc analysis of the TRITON-TIMI 38 trial.
Topics: Acute Coronary Syndrome; Aged; Circadian Rhythm; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Effect on platelet reactivity from a prasugrel loading dose after a clopidogrel loading dose compared with a prasugrel loading dose alone: Transferring From Clopidogrel Loading Dose to Prasugrel Loading Dose in Acute Coronary Syndrome Patients (TRIPLET):
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Drug Dosage Calculations; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Activation; Practice Guidelines as Topic; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2013 |
Grapefruit juice inhibits the metabolic activation of clopidogrel.
Topics: Adult; Area Under Curve; Beverages; Biotransformation; Citrus paradisi; Clopidogrel; Confidence Intervals; Cross-Over Studies; Female; Food-Drug Interactions; Genotype; Half-Life; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Purinergic P2Y12; Ticlopidine; Young Adult | 2014 |
Assessment of the risk of haemorrhage and its control following minor oral surgical procedures in patients on anti-platelet therapy: a prospective study.
Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Female; Hemostasis, Surgical; Humans; Male; Middle Aged; Oral Surgical Procedures; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Risk Factors; Ticlopidine | 2014 |
Paraoxonase-1 activity affects the clopidogrel response in CYP2C19 loss-of-function carriers.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2013 |
Cost-effectiveness of ticagrelor and generic clopidogrel in patients with acute coronary syndrome in Switzerland.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Cost-Benefit Analysis; Decision Support Techniques; Diagnostic Imaging; Double-Blind Method; Drug Costs; Drug Therapy, Combination; Drugs, Generic; Health Care Costs; Hospitalization; Humans; Markov Chains; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Quality-Adjusted Life Years; Switzerland; Ticagrelor; Ticlopidine | 2013 |
[Effectiveness and safety of tranexamic acid in patients receiving on-pump coronary artery bypass grafting without clopidogrel and aspirin cessation].
Topics: Aged; Aged, 80 and over; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Postoperative Hemorrhage; Prospective Studies; Ticlopidine; Tranexamic Acid | 2013 |
Twelve-month results of a randomized trial comparing mono with dual antiplatelet therapy in endovascularly treated patients with peripheral artery disease.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Germany; Humans; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a randomized, controlled trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2014 |
Combination of high on-treatment platelet aggregation and low deaggregation better predicts long-term cardiovascular events in PCI patients under dual antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Coronary Artery Disease; Disease-Free Survival; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Predictive Value of Tests; Survival Rate; Ticlopidine | 2014 |
Evolving pattern of platelet P2Y12 inhibition in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Blood Platelets; Clopidogrel; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine; United Kingdom | 2014 |
Clinical pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases.
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Lower mortality following pulmonary adverse events and sepsis with ticagrelor compared to clopidogrel in the PLATO study.
Topics: Adenosine; Aged; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Pneumonia; Sepsis; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Ischaemic cardiac outcomes in patients with atrial fibrillation treated with vitamin K antagonism or factor Xa inhibition: results from the ROCKET AF trial.
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Double-Blind Method; Embolism; Female; Humans; Kaplan-Meier Estimate; Male; Morpholines; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Rivaroxaban; Stroke; Thiophenes; Ticlopidine; Treatment Outcome; Warfarin | 2014 |
Dynamic changes and associated factors of clopidogrel resistance in patients after cerebral infarction.
Topics: Aged; Aged, 80 and over; Cerebral Infarction; Cholesterol; Clopidogrel; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Observation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Single-Blind Method; Stroke; Ticlopidine | 2013 |
Discharge aspirin dose and clinical outcomes in patients with acute coronary syndromes treated with prasugrel versus clopidogrel: an analysis from the TRITON-TIMI 38 study (trial to assess improvement in therapeutic outcomes by optimizing platelet inhibit
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Patient Discharge; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Relationship between statin type and responsiveness to clopidogrel in patients treated with percutaneous coronary intervention: a subgroup analysis of the CILON-T trial.
Topics: Aryl Hydrocarbon Hydroxylases; Atorvastatin; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Combined Modality Therapy; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Fluorobenzenes; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prognosis; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides; Ticlopidine | 2014 |
Pharmacokinetic and pharmacodynamic properties of batifiban coadministered with antithrombin agents in Chinese healthy volunteers.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Aspirin; China; Clopidogrel; Drug Administration Schedule; Female; Fibrinolytic Agents; Heparin; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Metabolic Clearance Rate; Peptides, Cyclic; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Young Adult | 2013 |
Population pharmacogenetic-based pharmacokinetic modeling of efavirenz, 7-hydroxy- and 8-hydroxyefavirenz.
Topics: Adult; Algorithms; Alkynes; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzoxazines; Chromatography, High Pressure Liquid; Clopidogrel; Computer Simulation; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 Enzyme System; DNA; Drug Interactions; Humans; Male; Models, Biological; Pharmacogenetics; Population; Reverse Transcriptase Inhibitors; Tandem Mass Spectrometry; Ticlopidine; Treatment Outcome; Young Adult | 2014 |
Effect of cilostazol addition or clopidogrel doubling on platelet function profiles in diabetic patients undergoing a percutaneous coronary intervention.
Topics: Blood Platelets; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Resistance; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Republic of Korea; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Pharmacodynamic effects of standard dose prasugrel versus high dose clopidogrel in non-diabetic obese patients with coronary artery disease.
Topics: Aspirin; Biomarkers; Blood Platelets; Body Mass Index; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Florida; Humans; Male; Microfilament Proteins; Middle Aged; Obesity; Phosphoproteins; Phosphorylation; Piperazines; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Short- versus long-term duration of dual antiplatelet therapy in patients treated for in-stent restenosis: a PRODIGY trial substudy (Prolonging Dual Antiplatelet Treatment After Grading Stent-Induced Intimal Hyperplasia).
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Restenosis; Female; Humans; Italy; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Stroke; Ticlopidine | 2014 |
Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Female; Follow-Up Studies; Humans; Intracranial Arteriosclerosis; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Single-Blind Method; Stents; Stroke; Ticlopidine; Treatment Outcome | 2014 |
Treatment patterns and outcomes in patients undergoing percutaneous coronary intervention treated with prasugrel or clopidogrel (from the Swedish Coronary Angiography and Angioplasty Registry [SCAAR]).
Topics: Acute Coronary Syndrome; Aged; Cause of Death; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; Retrospective Studies; Survival Rate; Sweden; Thiophenes; Ticlopidine; Treatment Outcome | 2014 |
Biomarkers in relation to the effects of ticagrelor in comparison with clopidogrel in non-ST-elevation acute coronary syndrome patients managed with or without in-hospital revascularization: a substudy from the Prospective Randomized Platelet Inhibition a
Topics: Acute Coronary Syndrome; Adenosine; Biomarkers; Clopidogrel; Electrocardiography; Growth Differentiation Factor 15; Hospital Mortality; Humans; Kaplan-Meier Estimate; Myocardial Revascularization; Natriuretic Peptide, Brain; Peptide Fragments; Predictive Value of Tests; Prognosis; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticagrelor; Ticlopidine; Troponin T | 2014 |
Poor agreement between light transmission aggregometry, Verify Now P2Y₁₂ and vasodilatator-stimulated phosphoprotein for clopidogrel low-response assessment: a potential explanation of negative results of recent randomized trials.
Topics: Cell Adhesion Molecules; Clopidogrel; Drug Monitoring; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2014 |
Three vs twelve months of dual antiplatelet therapy after zotarolimus-eluting stents: the OPTIMIZE randomized trial.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Sirolimus; Stroke; Thrombosis; Ticlopidine | 2013 |
[Effect of aspirin plus clopidogrel therapy on aspirin resistance after off-pump coronary artery bypass surgery].
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Period; Ticlopidine | 2013 |
Impact of intraprocedural stent thrombosis during percutaneous coronary intervention: insights from the CHAMPION PHOENIX Trial (Clinical Trial Comparing Cangrelor to Clopidogrel Standard of Care Therapy in Subjects Who Require Percutaneous Coronary Interv
Topics: Adenosine Monophosphate; Aged; Clopidogrel; Double-Blind Method; Female; Humans; Intraoperative Complications; Male; Middle Aged; Percutaneous Coronary Intervention; Prospective Studies; Standard of Care; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2014 |
Decreased circulating microRNA-223 level predicts high on-treatment platelet reactivity in patients with troponin-negative non-ST elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; MicroRNAs; Middle Aged; Platelet Aggregation Inhibitors; Real-Time Polymerase Chain Reaction; Retrospective Studies; Ticlopidine; Troponin | 2014 |
The effects of laropiprant on the antiplatelet activity of co-administered clopidogrel and aspirin.
Topics: Adult; Aged; Aspirin; Clopidogrel; Cross-Over Studies; Double-Blind Method; Drug Interactions; Dyslipidemias; Female; Humans; Hypercholesterolemia; Indoles; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2014 |
Effect of clopidogrel use post coronary artery bypass surgery on graft patency.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Education, Medical, Continuing; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Postoperative Care; Prospective Studies; Reference Values; Regression Analysis; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2014 |
A randomized controlled trial of platelet activity before and after cessation of clopidogrel therapy in patients with stable cardiovascular disease.
Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Treatment Outcome; Withholding Treatment | 2014 |
The effect of CYP2C19 genotype on the time course of platelet aggregation inhibition after clopidogrel administration.
Topics: Adult; Area Under Curve; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Sulfhydryl Compounds; Ticlopidine; Young Adult | 2014 |
Concomitant administration of clopidogrel with statins or calcium-channel blockers: insights from the TRITON-TIMI 38 (trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infarctio
Topics: Acute Coronary Syndrome; Aged; Calcium Channel Blockers; Clopidogrel; Double-Blind Method; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Prasugrel Hydrochloride; Propensity Score; Proportional Hazards Models; Proton Pump Inhibitors; Risk Factors; Stroke; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Impact of smoking on long-term outcomes in patients with atherosclerotic vascular disease treated with aspirin or clopidogrel: insights from the CAPRIE trial (Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events).
Topics: Aspirin; Atherosclerosis; Brain Ischemia; Clopidogrel; Female; Humans; Male; Risk Factors; Single-Blind Method; Smoking; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Prasugrel or double-dose clopidogrel to overcome clopidogrel low-response--the TAILOR (Thrombocytes And IndividuaLization of ORal antiplatelet therapy in percutaneous coronary intervention) randomized trial.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prognosis; Thiophenes; Ticlopidine; Treatment Outcome | 2014 |
Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Half-Life; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Microfilament Proteins; Omeprazole; Paris; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Rabeprazole; Ticlopidine | 2013 |
Pharmacoepidemiologic study of warfarin prescription in a Brazilian tertiary hospital.
Topics: Adult; Aged; Anticoagulants; Brazil; Clopidogrel; Cross-Sectional Studies; Databases, Factual; Dose-Response Relationship, Drug; Drug Incompatibility; Female; Hemorrhage; Humans; International Normalized Ratio; Male; Middle Aged; Pharmacoepidemiology; Prevalence; Socioeconomic Factors; Tertiary Care Centers; Ticlopidine; Warfarin | 2014 |
A randomized phase II trial investigating the effect of platelet function inhibition on circulating tumor cells in patients with metastatic breast cancer.
Topics: Aspirin; Blood Platelets; Breast Neoplasms; Case-Control Studies; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Middle Aged; Neoplasm Metastasis; Neoplastic Cells, Circulating; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine; Treatment Outcome | 2013 |
Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus.
Topics: Aged; Aspirin; Clopidogrel; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Herb-Drug Interactions; Humans; Male; Middle Aged; Phyllanthus emblica; Phytotherapy; Plant Extracts; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2014 |
Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Deaminase; Aged; C-Reactive Protein; Chromatography, Liquid; Clopidogrel; Cyclic AMP; Erythrocytes; Female; Humans; Male; Middle Aged; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2014 |
Morphine decreases clopidogrel concentrations and effects: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Clopidogrel; Cross-Over Studies; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Intestinal Absorption; Male; Morphine; Ticlopidine; Treatment Outcome; Young Adult | 2014 |
Two-year outcomes after first- or second-generation drug-eluting or bare-metal stent implantation in all-comer patients undergoing percutaneous coronary intervention: a pre-specified analysis from the PRODIGY study (PROlonging Dual Antiplatelet Treatment
Topics: Aged, 80 and over; Chi-Square Distribution; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Everolimus; Female; Humans; Hyperplasia; Italy; Kaplan-Meier Estimate; Male; Metals; Middle Aged; Myocardial Infarction; Neointima; Paclitaxel; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Factors; Sirolimus; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Effects of clopidogrel therapy on oxidative stress, inflammation, vascular function, and progenitor cells in stable coronary artery disease.
Topics: Aged; Biomarkers; Blood Vessels; Capillaries; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Elasticity; Endothelium, Vascular; Female; Humans; Inflammation; Male; Middle Aged; Oxidative Stress; Platelet Aggregation Inhibitors; Prospective Studies; Stem Cells; Ticlopidine; Vascular Stiffness | 2014 |
ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection?
Topics: Aged; Aspirin; Clopidogrel; Cohort Studies; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuroprotective Agents; Platelet Aggregation Inhibitors; Stroke, Lacunar; Ticlopidine; Time Factors; Treatment Failure | 2014 |
Pharmacodynamic comparison of pitavastatin versus atorvastatin on platelet reactivity in patients with coronary artery disease treated with dual antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Atorvastatin; Clopidogrel; Coronary Artery Disease; Cross-Sectional Studies; Cytochrome P-450 CYP3A; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyrroles; Quinolines; Ticlopidine | 2014 |
Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease.
Topics: Adolescent; Aged; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genetic Testing; Genotype; High-Throughput Screening Assays; Humans; Inactivation, Metabolic; International Cooperation; Male; Middle Aged; Point-of-Care Systems; Polymorphism, Genetic; Ticlopidine; Treatment Outcome; Young Adult | 2014 |
[Effects of preoperative uses of aspirin and clopidogrel on patients undergoing coronary artery bypass graft surgery].
Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Prognosis; Ticlopidine | 2013 |
Detecting a thienopyridine effect by platelet reactivity assessment and its implications for risk stratification.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Piperazines; Platelet Activation; Point-of-Care Systems; Prasugrel Hydrochloride; Pyridines; Receptors, Purinergic P2Y12; Reproducibility of Results; ROC Curve; Sensitivity and Specificity; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Multicenter randomized trial of 3-month cilostazol use in addition to dual antiplatelet therapy after biolimus-eluting stent implantation for long or multivessel coronary artery disease.
Topics: Aged; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Sirolimus; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Administration of a loading dose has no additive effect on platelet aggregation during the switch from ongoing clopidogrel treatment to ticagrelor in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Drug Dosage Calculations; Drug Substitution; Drug Synergism; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Clinical implications and correlates of Q waves in patients with ST-elevation myocardial infarction treated with fibrinolysis: observations from the CLARITY-TIMI 28 trial.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Circulation; Coronary Thrombosis; Creatine Kinase, MB Form; Electrocardiography; Female; Heart Failure; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Prognosis; Risk Assessment; Sex Factors; Ticlopidine | 2014 |
Von Willebrand factor antigen predicts response to double dose of aspirin and clopidogrel by PFA-100 in patients undergoing primary angioplasty for ST elevation myocardial infarction.
Topics: ADAM Proteins; ADAMTS13 Protein; Aged; Aspirin; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Retrospective Studies; Ticlopidine; von Willebrand Factor | 2013 |
N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention.
Topics: Aged; Angina, Stable; Aspirin; Blood Platelets; Clopidogrel; Docosahexaenoic Acids; Drug Combinations; Drug Therapy, Combination; Eicosapentaenoic Acid; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Poland; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Effect of ASA dose doubling versus switching to clopidogrel on plasma inflammatory markers concentration in patients with type 2 diabetes and high platelet reactivity: the AVOCADO study.
Topics: Aspirin; Biomarkers; Blood Platelets; C-Reactive Protein; CD40 Ligand; Chi-Square Distribution; Clopidogrel; Diabetes Mellitus, Type 2; Drug Substitution; Humans; Inflammation Mediators; Interleukin-6; Logistic Models; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Function Tests; Poland; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
A comparative evaluation of prasugrel and clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Adult; Aged; Aspirin; Clopidogrel; Combined Modality Therapy; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
One-year outcome of patients with atrial fibrillation undergoing coronary artery stenting: an analysis of the AFCAS registry.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Vessels; Female; Fibrinolytic Agents; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stents; Ticlopidine; Vitamin K | 2014 |
Coronary artery bypass grafting-related bleeding complications in real-life acute coronary syndrome patients treated with clopidogrel or ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Artery Bypass; Coronary Thrombosis; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Ticagrelor; Ticlopidine | 2014 |
Comparison of the antiplatelet effect of two clopidogrel bisulfate formulations: Plavix and generic-Egitromb.
Topics: Adult; Chemistry, Pharmaceutical; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Treatment Outcome | 2015 |
C-reactive protein as a prognostic marker after lacunar stroke: levels of inflammatory markers in the treatment of stroke study.
Topics: Aged; Antihypertensive Agents; Aspirin; Biomarkers; Blood Pressure; C-Reactive Protein; Clopidogrel; Cohort Studies; Confidence Intervals; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Male; Middle Aged; Phlebotomy; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Recurrence; Sample Size; Stroke, Lacunar; Ticlopidine; Treatment Outcome | 2014 |
Clopidogrel improves microvascular endothelial function in subjects with stable coronary artery disease.
Topics: Aged; Blood Coagulation; Clopidogrel; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Male; Microvessels; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Time Factors | 2014 |
Efficacy and safety of tirofiban-supported primary percutaneous coronary intervention in patients pretreated with 600 mg clopidogrel: results of propensity analysis using the Clinical Center of Serbia STEMI Register.
Topics: Aged; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Preoperative Care; Propensity Score; Registries; Retrospective Studies; Serbia; Survival Rate; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2014 |
Effect of clopidogrel with or without omeprazole in patients with carotid artery stenting.
Topics: Angiography; Aspirin; Breath Tests; Carotid Arteries; Carotid Stenosis; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Omeprazole; Peptic Ulcer; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stents; Ticlopidine | 2013 |
Aspirin decreases systemic exposure to clopidogrel through modulation of P-glycoprotein but does not alter its antithrombotic activity.
Topics: Adenosine Diphosphate; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Fibrinolytic Agents; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; RNA, Messenger; Ticlopidine | 2014 |
[The effect of clopidogrel and aspigrel on myocardial ischemia in patients with unstable angina pectoris].
Topics: Aged; Angina, Unstable; Aspirin; Clopidogrel; Drug Combinations; Drug Therapy, Combination; Humans; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2013 |
Comparative-effectiveness of revascularization versus routine medical therapy for stable ischemic heart disease: a population-based study.
Topics: Adrenergic beta-Antagonists; Aged; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Ischemia; Myocardial Revascularization; Platelet Aggregation Inhibitors; Population Surveillance; Retrospective Studies; Ticlopidine; Treatment Outcome | 2014 |
Prevention of gastric mucosal injury induced by anti-platelet drugs by famotidine.
Topics: Adult; Anti-Ulcer Agents; Asian People; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Famotidine; Female; Gastric Acidity Determination; Gastric Mucosa; Genotype; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2014 |
Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type.
Topics: Aspirin; Blood Vessel Prosthesis; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Female; Fibrinolytic Agents; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Prosthesis Failure; Sirolimus; Ticlopidine; Treatment Outcome | 2014 |
Antiplatelet effects of clopidogrel dose adjustment (75 mg/d vs 150 mg/d) after carotid stenting.
Topics: Aged; Angioplasty; Blood Platelets; Carotid Artery Diseases; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Spain; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Outcomes in patients with ST-segment elevation acute myocardial infarction treated with clopidogrel versus prasugrel (from the INFUSE-AMI trial).
Topics: Antithrombins; Clopidogrel; Coronary Angiography; Electrocardiography; Female; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Recombinant Proteins; Thiophenes; Ticlopidine; Treatment Outcome | 2014 |
Randomised, double-blind trial on the value of tapered discontinuation of clopidogrel maintenance therapy after drug-eluting stent implantation. Intracoronary Stenting and Antithrombotic Regimen: CAUTION in Discontinuing Clopidogrel Therapy--ISAR-CAUTION.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Double-Blind Method; Drug-Eluting Stents; Female; Fibrinolytic Agents; Humans; Maintenance Chemotherapy; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Comparison of prasugrel and bivalirudin vs clopidogrel and heparin in patients with ST-segment elevation myocardial infarction: Design and rationale of the Bavarian Reperfusion Alternatives Evaluation (BRAVE) 4 trial.
Topics: Anticoagulants; Clopidogrel; Drug Therapy, Combination; Female; Heparin; Hirudins; Humans; Male; Myocardial Infarction; Peptide Fragments; Percutaneous Coronary Intervention; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Recombinant Proteins; Thiophenes; Ticlopidine; Treatment Outcome | 2014 |
Ticagrelor treatment in patients with acute coronary syndrome is cost-effective in Sweden and Denmark.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Cost-Benefit Analysis; Denmark; Humans; Purinergic P2Y Receptor Antagonists; Sweden; Ticagrelor; Ticlopidine | 2014 |
A comparative pharmacodynamic study of ticagrelor versus clopidogrel and ticagrelor in patients undergoing primary percutaneous coronary intervention: the CAPITAL RELOAD study.
Topics: Adenosine; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Ticagrelor; Ticlopidine | 2014 |
Switching from high-dose clopidogrel to prasugrel in ACS patients undergoing PCI: a single-center experience.
Topics: Acute Coronary Syndrome; Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Substitution; Female; Follow-Up Studies; Humans; Male; Middle Aged; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2014 |
Switching from clopidogrel to prasugrel in patients having coronary stent implantation.
Topics: Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Drug Substitution; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Renal Insufficiency, Chronic; Sex Factors; Stents; Thiophenes; Thrombosis; Ticlopidine | 2014 |
A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel.
Topics: Adult; Alanine; Anti-Ulcer Agents; Aspirin; Clopidogrel; Double-Blind Method; Gastric Mucosa; Gastrointestinal Hemorrhage; Healthy Volunteers; Humans; Male; Peptic Ulcer; Platelet Aggregation Inhibitors; Quinolones; Ticlopidine; Young Adult | 2014 |
Inhibition of platelet activation could decrease thrombotic events in hemodialysis PF4/H antibody-positive patients.
Topics: Adult; Aged; Aspirin; Clopidogrel; Female; Humans; Incidence; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Factor 4; Renal Dialysis; Thrombosis; Ticlopidine | 2014 |
Impact of dual antiplatelet therapy on outcomes among aspirin-resistant patients following coronary artery bypass grafting.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Croatia; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Incidence; Male; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Retrospective Studies; Survival Rate; Ticlopidine; Treatment Outcome | 2014 |
Comparative bioavailability of two oral formulations of clopidogrel: determination of clopidogrel and its carboxylic acid metabolite (SR26334) under fasting and fed conditions in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Chemistry, Pharmaceutical; Clopidogrel; Cross-Over Studies; Fasting; Humans; Male; Middle Aged; Postprandial Period; Ticlopidine; Young Adult | 2014 |
Effect of esomeprazole with/without acetylsalicylic acid, omeprazole and lansoprazole on pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.
Topics: Adolescent; Adult; Area Under Curve; Aspirin; Clopidogrel; Cross-Over Studies; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Healthy Volunteers; Humans; Lansoprazole; Male; Middle Aged; Omeprazole; Platelet Aggregation; Proton Pump Inhibitors; Ticlopidine; Young Adult | 2014 |
The efficacy of ticagrelor is maintained in women with acute coronary syndromes participating in the prospective, randomized, PLATelet inhibition and patient Outcomes (PLATO) trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Recurrence; Sex Factors; Stents; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aorta, Thoracic; Aortic Diseases; Aspirin; Brain Ischemia; Clopidogrel; Drug Therapy, Combination; Embolism; Female; Humans; Male; Middle Aged; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Prospective Studies; Single-Blind Method; Stroke; Ticlopidine; Treatment Outcome; Warfarin | 2014 |
Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers.
Topics: Adult; Aged; Amish; Area Under Curve; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2014 |
Transferring from clopidogrel loading dose to prasugrel loading dose in acute coronary syndrome patients. High on-treatment platelet reactivity analysis of the TRIPLET trial.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Administration Schedule; Drug Resistance; Drug Substitution; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Phenotype; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Antiplatelet effect of clopidogrel can be reduced by calcium-channel blockers.
Topics: Aged; Aged, 80 and over; Blood Platelets; Calcium Channel Blockers; Clopidogrel; Dihydropyridines; Drug Interactions; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Pharmacodynamic efficacy and safety of adjunctive cilostazol loading to clopidogrel and aspirin loading: the results of the ACCEL-LOADING (Accelerated Platelet Inhibition by Cilostazol Loading) study.
Topics: Aspirin; Cilostazol; Clopidogrel; Cross-Over Studies; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Prospective Studies; Tetrazoles; Ticlopidine | 2014 |
Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Retrospective Studies; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Impact of preoperative fibrinogen concentration on postoperative outcome in patients who received dual antiplatelet therapy in proximity to off-pump coronary bypass surgery.
Topics: Aged; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Fibrinogen; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Preoperative Care; Preoperative Period; Retrospective Studies; Risk Factors; Ticlopidine | 2014 |
A comparative study of dual versus monoantiplatelet therapy in patients with acute large-artery atherosclerosis stroke.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Endpoint Determination; Female; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Stroke; Ticlopidine | 2014 |
Prospective validation of the Bleeding Academic Research Consortium classification in the all-comer PRODIGY trial.
Topics: Administration, Oral; Aged; Aspirin; Clopidogrel; Epidemiologic Methods; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 2014 |
Efficacy and safety of adjusted-dose prasugrel compared with clopidogrel in Japanese patients with acute coronary syndrome: the PRASFIT-ACS study.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Asian People; Aspirin; Clopidogrel; Drug Therapy, Combination; Follow-Up Studies; Hemorrhage; Humans; Japan; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Time Factors | 2014 |
Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy.
Topics: Aged; Anticholesteremic Agents; Aspirin; Azetidines; Cell-Derived Microparticles; Cholesterol, LDL; Clopidogrel; Coronary Disease; Drug Combinations; Endothelial Progenitor Cells; Ezetimibe; Female; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Simvastatin; Ticlopidine; Triglycerides | 2014 |
Impact of CYP3A5 polymorphism on platelet reactivity at percutaneous coronary intervention and after 9 months of aspirin and clopidogrel therapy in Japanese patients with coronary artery disease.
Topics: Asian People; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Therapy, Combination; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Time Factors | 2014 |
A retrospective review of clopidogrel as primary therapy for migraineurs with right to left shunt lesions.
Topics: Adolescent; Adult; Clopidogrel; Female; Foramen Ovale, Patent; Humans; Middle Aged; Migraine with Aura; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Young Adult | 2014 |
The influence of genetic polymorphism of Cyp2c19 isoenzyme on the pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases.
Topics: Area Under Curve; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Isoenzymes; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2014 |
Effects of clopidogrel, prasugrel and ticagrelor on endothelial function, inflammatory and oxidative stress parameters and platelet function in patients undergoing coronary artery stenting for an acute coronary syndrome. A randomised, prospective, control
Topics: Acute Coronary Syndrome; Adenosine; Adolescent; Adult; Aged; Blood Platelets; Clopidogrel; Drug-Eluting Stents; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oxidative Stress; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Single-Blind Method; Ticagrelor; Ticlopidine; Treatment Outcome; Young Adult | 2014 |
Interaction of clopidogrel and statins in secondary prevention after cerebral ischaemia - a randomized, double-blind, double-dummy crossover study.
Topics: Aged; Brain Ischemia; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP3A; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Simvastatin; Substrate Specificity; Ticlopidine | 2014 |
Prasugrel plus bivalirudin vs. clopidogrel plus heparin in patients with ST-segment elevation myocardial infarction.
Topics: Aged; Anticoagulants; Clopidogrel; Coronary Angiography; Coronary Stenosis; Drug Therapy, Combination; Early Termination of Clinical Trials; Heparin; Hirudins; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Recombinant Proteins; Thiophenes; Ticlopidine; Treatment Outcome | 2014 |
Clinical outcomes for prasugrel versus clopidogrel in patients with unstable angina or non-ST-elevation myocardial infarction: an analysis from the TRITON-TIMI 38 trial.
Topics: Angina, Unstable; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Ticlopidine; Treatment Outcome | 2014 |
Cardiovascular events in acute coronary syndrome patients with peripheral arterial disease treated with ticagrelor compared with clopidogrel: Data from the PLATO Trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Factors; Stroke; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
A prospective randomised study of the paclitaxel-coated balloon catheter in bifurcated coronary lesions (BABILON trial): 24-month clinical and angiographic results.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Drug-Eluting Stents; Everolimus; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine; Treatment Outcome; Tubulin Modulators | 2014 |
Clopidogrel as prophylactic treatment for migraine: a pilot randomised, controlled study.
Topics: Adult; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Migraine Disorders; Pilot Projects; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2014 |
Serial clopidogrel dose adjustment after platelet function testing improves outcome of acute coronary syndrome patients undergoing percutaneous coronary intervention with high on-treatment platelet reactivity.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2014 |
Comparing the effect of clopidogrel versus ticagrelor on coronary microvascular dysfunction in acute coronary syndrome patients (TIME trial): study protocol for a randomized controlled trial.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Protocols; Clopidogrel; Coronary Circulation; Coronary Vessels; Humans; Microcirculation; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Republic of Korea; Research Design; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography | 2014 |
High clopidogrel dose in patients with chronic kidney disease having clopidogrel resistance after percutaneous coronary intervention.
Topics: Aged; China; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Administration Schedule; Drug Resistance; Drug-Eluting Stents; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Renal Insufficiency, Chronic; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Pharmacodynamics, pharmacokinetics and safety of ticagrelor in Asian patients with stable coronary artery disease.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Asian People; Aspirin; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Young Adult | 2014 |
Pharmacodynamic effects of cilostazol versus clopidogrel in stented patients under proton pump inhibitor co-administration: the ACCEL-PARAZOL study.
Topics: Cardiovascular Diseases; Cilostazol; Clopidogrel; Female; Follow-Up Studies; Humans; Lansoprazole; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Prospective Studies; Proton Pump Inhibitors; Renal Insufficiency, Chronic; Stents; Tetrazoles; Ticlopidine | 2014 |
Prasugrel versus clopidogrel in patients with ST-segment elevation myocardial infarction according to timing of percutaneous coronary intervention: a TRITON-TIMI 38 subgroup analysis (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Plate
Topics: Aged; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes; Thrombolytic Therapy; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Platelet reactivity and cardiovascular events after percutaneous coronary intervention in patients with stable coronary artery disease: the Stent Thrombosis In Belgium (STIB) trial.
Topics: Aged; Angina, Stable; Aspirin; Belgium; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Female; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Risk Factors; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
CYP2C19 genotype-guided antiplatelet therapy in ST-segment elevation myocardial infarction patients-Rationale and design of the Patient Outcome after primary PCI (POPular) Genetics study.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Electrocardiography; Female; Follow-Up Studies; Genetic Techniques; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome; Young Adult | 2014 |
Impact of smoking status on platelet function and clinical outcomes with prasugrel vs. clopidogrel in patients with acute coronary syndromes managed without revascularization: Insights from the TRILOGY ACS trial.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Revascularization; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prognosis; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Smoking; Survival Rate; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome; United Kingdom; United States | 2014 |
Clopidogrel dose adjustment after outpatient screening for CYP2C19 variant alleles: a pilot study.
Topics: Aged; Alleles; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Female; Genetic Testing; Humans; Male; Middle Aged; Outpatients; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Causes of mortality with ticagrelor compared with clopidogrel in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Age Factors; Aged; Cause of Death; Clopidogrel; Confidence Intervals; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Survival Analysis; Ticagrelor; Ticlopidine; Time Factors | 2014 |
Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.
Topics: Aryl Hydrocarbon Hydroxylases; Carbamates; Catalytic Domain; Clopidogrel; Computer Simulation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Drug Interactions; Female; Glucuronides; Humans; Hypoglycemic Agents; Male; Metabolic Detoxication, Phase II; Molecular Docking Simulation; Piperidines; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2014 |
Monitoring the efficacy of ADP inhibitor treatment in patients with acute STEMI post-PCI by VASP-P flow cytometry assay.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Flow Cytometry; Follow-Up Studies; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Phosphoproteins; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2015 |
The effect of CYP2C19 gene polymorphisms on the pharmacokinetics and pharmacodynamics of prasugrel 5-mg, prasugrel 10-mg and clopidogrel 75-mg in patients with coronary artery disease.
Topics: Aged; Clinical Protocols; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Phenotype; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Treatment Outcome | 2014 |
Applying novel methods to assess clinical outcomes: insights from the TRILOGY ACS trial.
Topics: Aged; Angina, Unstable; Clopidogrel; Endpoint Determination; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Recurrence; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome | 2015 |
Prasugrel but not high dose clopidogrel overcomes the lansoprazole neutralizing effect of P2Y12 inhibition: Results of the randomized DOSAPI study.
Topics: Adult; Aged; Anti-Ulcer Agents; Aspirin; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Interactions; Female; Humans; Lansoprazole; Male; Middle Aged; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2014 |
An analysis of TRITON-TIMI 38, based on the 12 month recommended length of therapy in the European label for prasugrel.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Drug Administration Schedule; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Stents; Stroke; Thiophenes; Ticlopidine | 2014 |
The impact of a 600-mg loading dose of clopidogrel in diabetic and non-diabetic patients undergoing elective PCI.
Topics: Aged; Clopidogrel; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Stents; Ticlopidine; Treatment Outcome | 2016 |
Switching patients from clopidogrel to prasugrel in acute coronary syndrome: impact of the clopidogrel loading dose on platelet reactivity.
Topics: Acute Coronary Syndrome; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2014 |
Platelet function in Takotsubo cardiomyopathy.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Epinephrine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Registries; Takotsubo Cardiomyopathy; Ticlopidine | 2015 |
Variability of individual platelet reactivity over time in patients treated with clopidogrel: insights from the ELEVATE-TIMI 56 trial.
Topics: Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2014 |
Effects of clopidogrel on horses with experimentally induced endotoxemia.
Topics: Analysis of Variance; Animals; Body Temperature; Clopidogrel; Endotoxemia; Female; Fibrinogen; Flow Cytometry; Heart Rate; Horse Diseases; Horses; Lipopolysaccharides; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Respiratory Rate; Thrombelastography; Ticlopidine; Tumor Necrosis Factor-alpha; von Willebrand Factor | 2014 |
Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639).
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Care; Ticlopidine | 2015 |
Ticagrelor reduces thrombus formation more than clopidogrel, even when co-administered with bivalirudin.
Topics: Adenosine; Adult; Antithrombins; Aspirin; Blood Coagulation; Clopidogrel; Cross-Over Studies; Drug Synergism; Female; Healthy Volunteers; Hirudins; Humans; Male; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Recombinant Proteins; Thrombelastography; Ticagrelor; Ticlopidine | 2014 |
CYP2C19*17 increases clopidogrel-mediated platelet inhibition but does not alter the pharmacokinetics of the active metabolite of clopidogrel.
Topics: Area Under Curve; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Male; Platelet Aggregation; Polymorphism, Single Nucleotide; Proguanil; Prospective Studies; Purinergic P2Y Receptor Antagonists; Substrate Specificity; Ticlopidine; Time Factors | 2014 |
The net clinical benefit of personalized antiplatelet therapy in patients undergoing percutaneous coronary intervention.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Prospective Studies; Purinergic P2Y Receptor Antagonists; Regression Analysis; Thiophenes; Ticlopidine | 2015 |
Influence of carotid artery stenting on cognition of elderly patients with severe stenosis of the internal carotid artery.
Topics: Aged; Analysis of Variance; Angioplasty; Aspirin; Atorvastatin; Carotid Stenosis; China; Clopidogrel; Cognition; Female; Heptanoic Acids; Humans; Male; Pyrroles; Quality of Life; Regional Blood Flow; Stents; Ticlopidine; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2014 |
Predictors of mortality in patients with lacunar stroke in the secondary prevention of small subcortical strokes trial.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Secondary Prevention; Stroke, Lacunar; Ticlopidine | 2014 |
Prehospital ticagrelor in ST-segment elevation myocardial infarction.
Topics: Adenosine; Aged; Anticoagulants; Clopidogrel; Coronary Angiography; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Emergency Medical Services; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Time-to-Treatment | 2014 |
MULTInational non-interventional study of patients with ST-segment elevation myocardial infarction treated with PRimary Angioplasty and Concomitant use of upstream antiplatelet therapy with prasugrel or clopidogrel--the European MULTIPRAC Registry.
Topics: Acute Coronary Syndrome; Aged; Antithrombins; Clopidogrel; Drug Therapy, Combination; Europe; Female; Hemorrhage; Hirudins; Humans; Internationality; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Recombinant Proteins; Ticlopidine; Treatment Outcome | 2015 |
Effect of adjunctive dipyridamole to DAPT on platelet function profiles in stented patients with high platelet reactivity. The result of the ACCEL-DIP Study.
Topics: Aged; Aspirin; ATP Binding Cassette Transporter, Subfamily B; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Dipyridamole; Drug Resistance; Drug Therapy, Combination; Female; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Percutaneous Coronary Intervention; Phosphodiesterase 5 Inhibitors; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Republic of Korea; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Initial 3-weeks' Apixaban Versus Dual-antiplatelet Therapy (Clopidogrel and Aspirin) followed by Clopidogrel alone in high-risk patients with Acute Non-Disabling Cerebrovascular Events (ADANCE): study protocol for a randomized controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Aspirin; Clopidogrel; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Endpoint Determination; Female; Humans; Male; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Stroke; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2014 |
Efficacy of two different self-expanding nitinol stents for atherosclerotic femoropopliteal arterial disease (SENS-FP trial): study protocol for a randomized controlled trial.
Topics: Alloys; Angioplasty, Balloon; Aspirin; Cilostazol; Clinical Protocols; Clopidogrel; Drug Therapy, Combination; Femoral Artery; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Popliteal Artery; Prospective Studies; Prosthesis Design; Prosthesis Failure; Research Design; Stents; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2014 |
Clopidogrel plus aspirin versus aspirin alone for preventing early neurological deterioration in patients with acute ischemic stroke.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stroke; Ticlopidine; Treatment Outcome; United States | 2015 |
Relationship between ABCB1 polymorphisms, thromboelastography and risk of bleeding events in clopidogrel-treated patients with ST-elevation myocardial infarction.
Topics: Aged; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Risk Factors; Thrombelastography; Ticlopidine | 2014 |
Point-of-care measurements of platelet inhibition after clopidogrel loading in patients with acute coronary syndrome: comparison of generic and branded clopidogrel bisulfate.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Drugs, Generic; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Testing; Prospective Studies; Therapeutic Equivalency; Ticlopidine | 2014 |
Switching from generic to brand clopidogrel in male patients after ST-elevated myocardial infarction.
Topics: Adenosine Diphosphate; Aspirin; Clopidogrel; Drug Substitution; Drug Therapy, Combination; Drugs, Generic; Epinephrine; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2014 |
Health economic analysis of ticagrelor in patients with acute coronary syndromes intended for non-invasive therapy.
Topics: Acute Coronary Syndrome; Adenosine; Brazil; Clopidogrel; Cost-Benefit Analysis; Disease Management; Electrocardiography; Female; Germany; Health Care Costs; Humans; Male; Markov Chains; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Quality of Life; Quality-Adjusted Life Years; Secondary Prevention; Sweden; Ticagrelor; Ticlopidine; United Kingdom | 2015 |
Clopidogrel plus aspirin prevents early neurologic deterioration and improves 6-month outcome in patients with acute large artery atherosclerosis stroke.
Topics: Acute Disease; Aged; Aspirin; Atherosclerosis; Clopidogrel; Female; Humans; Male; Nervous System Diseases; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2015 |
Association of spontaneous and procedure-related bleeds with short- and long-term mortality after acute coronary syndromes: an analysis from the PLATO trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Double-Blind Method; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Predictive Value of Tests; Proportional Hazards Models; Risk Assessment; Risk Factors; Severity of Illness Index; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Saphenous vein graft failure after coronary artery bypass surgery: insights from PREVENT IV.
Topics: Aged; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Double-Blind Method; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Predictive Value of Tests; Risk Assessment; Saphenous Vein; Ticlopidine; Vascular Patency | 2014 |
A randomised trial of the pharmacodynamic and pharmacokinetic effects of ticagrelor compared with clopidogrel in Hispanic patients with stable coronary artery disease.
Topics: Adenosine; Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Hispanic or Latino; Humans; Middle Aged; Platelet Activation; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
Prasugrel, a third-generation P2Y12 receptor antagonist, in patients with coronary artery disease undergoing elective percutaneous coronary intervention.
Topics: Aged; Brain Ischemia; Clopidogrel; Combined Modality Therapy; Coronary Disease; Cytochrome P-450 CYP2C19; Double-Blind Method; Elective Surgical Procedures; Female; Follow-Up Studies; Gene Frequency; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation; Postoperative Complications; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Ticlopidine | 2014 |
Valsartan combined with clopidogrel and/or leflunomide for the treatment of progressive immunoglobulin A nephropathy.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Biomarkers; China; Clopidogrel; Creatinine; Disease Progression; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Glomerulonephritis, IGA; Humans; Immunosuppressive Agents; Isoxazoles; Kidney; Leflunomide; Male; Platelet Aggregation Inhibitors; Proteinuria; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome; Valine; Valsartan | 2015 |
Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents.
Topics: Aged; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Ischemia; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine; Time Factors | 2014 |
Relationship between smoking and responsiveness to clopidogrel in non-cardiogenic ischemic stroke patients.
Topics: Adenosine Diphosphate; Aged; Blood Coagulation Tests; Clopidogrel; Drug Resistance; Female; Humans; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Smoking; Stroke; Ticlopidine | 2014 |
A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism.
Topics: Adenosine Diphosphate; Clopidogrel; Cytochrome P-450 CYP2C19; Drugs, Chinese Herbal; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Maintenance Chemotherapy; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Ticlopidine; Treatment Outcome | 2014 |
Tradeoff between bleeding and stent thrombosis in different dual antiplatelet therapy regimes: Importance of case fatality rates and effective treatment durations.
Topics: Aged; Angina Pectoris; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Maintenance Chemotherapy; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Failure; Risk Assessment; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Early high-dose rosuvastatin and cardioprotection in the protective effect of rosuvastatin and antiplatelet therapy on contrast-induced acute kidney injury and myocardial damage in patients with acute coronary syndrome (PRATO-ACS) study.
Topics: Acute Coronary Syndrome; Acute Kidney Injury; Cardiotonic Agents; Clopidogrel; Contrast Media; Coronary Angiography; Creatine Kinase, MB Form; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardium; Necrosis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Pyrimidines; Rosuvastatin Calcium; Sulfonamides; Ticlopidine; Treatment Outcome; Troponin I | 2014 |
Superiority of ticagrelor over clopidogrel in patients after cardiac arrest undergoing therapeutic hypothermia.
Topics: Adenosine; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heart Arrest; Humans; Hypothermia, Induced; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial.
Topics: Aged; Aspirin; Blood Pressure; Clopidogrel; Cognition; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke, Lacunar; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Vorapaxar with or without clopidogrel after non-ST-segment elevation acute coronary syndromes: results from the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome trial.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug Monitoring; Drug Therapy, Combination; Electrocardiography; Female; Hemorrhage; Humans; Lactones; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Secondary Prevention; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome | 2014 |
6- versus 24-month dual antiplatelet therapy after implantation of drug-eluting stents in patients nonresistant to aspirin: the randomized, multicenter ITALIC trial.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Coronary Vessels; Drug-Eluting Stents; Early Termination of Clinical Trials; Europe; Everolimus; Female; Hemorrhage; Humans; Immunosuppressive Agents; Male; Middle Aged; Middle East; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Is clopidogrel better than aspirin following breakthrough strokes while on aspirin? A retrospective cohort study.
Topics: Aged; Aspirin; Brain Ischemia; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Hospitalization; Humans; Incidence; Male; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Survival Rate; Taiwan; Ticlopidine; Treatment Outcome | 2014 |
Does rectal indomethacin given for prevention of post-ERCP pancreatitis increase bleeding after biliary endoscopic sphincterotomy or cardiovascular mortality?: Post hoc analysis using prospective clinical trial data.
Topics: Administration, Rectal; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Cholangiopancreatography, Endoscopic Retrograde; Clopidogrel; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Pancreatitis; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Sphincterotomy, Endoscopic; Ticlopidine | 2014 |
Protocol for Cilostazol Stroke Prevention Study for Antiplatelet Combination (CSPS.com): a randomized, open-label, parallel-group trial.
Topics: Aged; Aspirin; Brain Ischemia; Cilostazol; Clopidogrel; Drug Therapy, Combination; Humans; Phosphodiesterase 3 Inhibitors; Platelet Aggregation Inhibitors; Recurrence; Research Design; Stroke; Tetrazoles; Ticlopidine | 2015 |
Residual platelet reactivity to predict long-term clinical outcomes after clopidogrel loading in patients with acute coronary syndromes: comparison of different cutoff values by light transmission aggregometry from the responsiveness to clopidogrel and st
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Cohort Studies; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Rationale and design of MANJUSRI trial: a randomized, open-label, active-controlled multicenter study to evaluate the safety of combined therapy with ticagrelor and warfarin in AF subjects after PCI-eS.
Topics: Adenosine; Adolescent; Adult; Aged; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Prospective Studies; Research Design; Ticagrelor; Ticlopidine; Warfarin; Young Adult | 2015 |
Incidence, predictors, and prognostic impact of late bleeding complications after transcatheter aortic valve replacement.
Topics: Aged; Aged, 80 and over; Aortic Valve Stenosis; Aspirin; Clopidogrel; Echocardiography; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Kaplan-Meier Estimate; Male; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Prognosis; Risk Assessment; Severity of Illness Index; Survival Rate; Ticlopidine; Transcatheter Aortic Valve Replacement | 2014 |
Efficacy of Change to New P2Y12 Receptor Antagonists in Patients High on Treatment Platelet Reactivity Undergoing Percutaneous Coronary Intervention.
Topics: Aged; Clopidogrel; Female; Heart Diseases; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Ticlopidine | 2015 |
Genetic polymorphisms of CYP2C19 2 and ABCB1 C3435T affect the pharmacokinetic and pharmacodynamic responses to clopidogrel in 401 patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Female; Humans; Inactivation, Metabolic; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Ticlopidine | 2015 |
Active metabolite concentration of clopidogrel in patients taking different doses of aspirin: results of the interaction trial.
Topics: Activation, Metabolic; Aged; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Genotype; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2015 |
Reticulated platelets and antiplatelet therapy response in diabetic patients.
Topics: Adult; Aged; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Assessment of the efficacy and tolerability of clopidogrel napadisilate in Korean patients with coronary stenting: a multicenter, prospective, open-label, randomized trial.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Drug Monitoring; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Republic of Korea; Ticlopidine; Treatment Outcome | 2015 |
Prasugrel and ticagrelor compared to clopidogrel in non-ST-segment elevation acute coronary syndromes undergoing percutaneous coronary interventions: Certainties and uncertainties.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticagrelor; Ticlopidine | 2015 |
Limited impact of drug exposure misclassification from non-benefit thiazolidinedione drug use on mortality and hospitalizations from Saskatchewan, Canada: a cohort study.
Topics: Aged; Clopidogrel; Cohort Studies; Databases, Factual; Female; Hospitalization; Humans; Hypoglycemic Agents; Male; Middle Aged; Saskatchewan; Thiazolidinediones; Ticlopidine | 2015 |
Physiologically based pharmacokinetic modeling for sequential metabolism: effect of CYP2C19 genetic polymorphism on clopidogrel and clopidogrel active metabolite pharmacokinetics.
Topics: Adolescent; Adult; Aged; Amiodarone; Area Under Curve; Biotransformation; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Double-Blind Method; Dronedarone; Drug Interactions; Humans; Intestinal Absorption; Male; Middle Aged; Models, Biological; Polymorphism, Single Nucleotide; Reproducibility of Results; Secondary Metabolism; Ticlopidine; Tissue Distribution; Young Adult | 2015 |
Comparison of prasugrel and clopidogrel-treated patients with acute coronary syndrome undergoing percutaneous coronary intervention: A propensity score-matched analysis of the Acute Myocardial Infarction in Switzerland (AMIS)-Plus Registry.
Topics: Acute Coronary Syndrome; Acute Disease; Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; Switzerland; Ticlopidine; Treatment Outcome | 2016 |
ISAR-SAFE: a randomized, double-blind, placebo-controlled trial of 6 vs. 12 months of clopidogrel therapy after drug-eluting stenting.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Administration Schedule; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Failure; Stroke; Ticlopidine; Treatment Outcome | 2015 |
Double-blind, randomized, prospective comparison of loading doses of 600 mg clopidogrel versus 60 mg prasugrel in patients with acute ST-segment elevation myocardial infarction scheduled for primary percutaneous intervention: the ETAMI trial (early thieno
Topics: Aged; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Vessels; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Phosphoproteins; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2015 |
Platelet reactivity after receiving clopidogrel compared with ticagrelor in patients with kidney failure treated with hemodialysis: a randomized crossover study.
Topics: Adenosine; Adult; Aspirin; Clopidogrel; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Renal Dialysis; Single-Blind Method; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
Relationship between degree of left ventricular dysfunction, symptom status, and risk of embolic events in patients with atrial fibrillation and heart failure.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Biphenyl Compounds; Clopidogrel; Female; Heart Failure; Humans; Irbesartan; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Stroke; Tetrazoles; Thromboembolism; Ticlopidine; Treatment Outcome; Ventricular Dysfunction, Left | 2015 |
Impact of impaired glucose tolerance on clopidogrel response in patients with coronary artery disease.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Middle Aged; Ticlopidine; Time Factors | 2015 |
Statistical analysis plan for the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Double-Blind Method; Female; Humans; International Cooperation; Male; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2015 |
Comparison of patient intake of ticagrelor, prasugrel, or clopidogrel on restoring platelet function by donor platelets.
Topics: Adenosine; Adenosine Diphosphate; Aged; Blood Platelets; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Flow Cytometry; Half-Life; Humans; Male; Middle Aged; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Transfusion; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2015 |
Economic analysis of ticagrelor therapy from a U.S. perspective: results from the PLATO study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Cohort Studies; Cost-Benefit Analysis; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome; United States | 2015 |
Comparison of the antiplatelet effect of clopidogrel hydrogenosulfate and clopidogrel besylate in patients with stable coronary artery disease.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Heterozygote; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Ticlopidine | 2015 |
Ticagrelor versus high dose clopidogrel in ST-segment elevation myocardial infarction patients with high platelet reactivity post fibrinolysis.
Topics: Adenosine; Aged; Blood Platelets; Clopidogrel; Female; Fibrinolysis; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Prospective Studies; Ticagrelor; Ticlopidine | 2015 |
Differential impact of selective serotonin reuptake inhibitors on platelet response to clopidogrel: a randomized, double-blind, crossover trial.
Topics: Adult; Citalopram; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Double-Blind Method; Drug Interactions; Fluvoxamine; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prodrugs; Selective Serotonin Reuptake Inhibitors; Ticlopidine; Young Adult | 2015 |
Outcomes with cangrelor versus clopidogrel on a background of bivalirudin: insights from the CHAMPION PHOENIX (A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention [PCI]).
Topics: Adenosine Monophosphate; Aged; Anticoagulants; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Double-Blind Method; Female; Hemorrhage; Hirudins; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recombinant Proteins; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Impact of clinical presentation on ischaemic and bleeding outcomes in patients receiving 6- or 24-month duration of dual-antiplatelet therapy after stent implantation: a pre-specified analysis from the PRODIGY (Prolonging Dual-Antiplatelet Treatment After
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Hemorrhage; Humans; Hyperplasia; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Stents; Stroke; Ticlopidine; Tunica Intima | 2015 |
Zotarolimus-eluting versus bare-metal stents in uncertain drug-eluting stent candidates.
Topics: Aged; Aged, 80 and over; Aspirin; Biocompatible Materials; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Hemorrhage; Humans; Immunosuppressive Agents; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Assessment; Risk Factors; Sirolimus; Ticlopidine; Treatment Outcome | 2015 |
Glycated albumin predicts the effect of dual and single antiplatelet therapy on recurrent stroke.
Topics: Aged; Aspirin; Biomarkers; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Serum Albumin; Stroke; Ticlopidine | 2015 |
Reduced Effect of Aspirin and Clopidogrel Following Hybrid Coronary Revascularization.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Prospective Studies; Ticlopidine | 2015 |
[Possibilities and results of using clopidogrel (Listab) in comprehensive treatment of patients with crural deep veins thrombosis].
Topics: Adult; Aged; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Leg; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Retrospective Studies; Ticlopidine; Treatment Outcome; Venous Thrombosis | 2015 |
Generic Clopidogrel Besylate in the Secondary Prevention of Atherothrombotic Events: A 6-month Follow-up of a Randomised Clinical Trial.
Topics: Aged; Aged, 80 and over; Clopidogrel; Drugs, Generic; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Safety profile of prasugrel and clopidogrel in patients with acute coronary syndromes in Switzerland.
Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clopidogrel; Drug-Eluting Stents; Female; Guideline Adherence; Hemorrhage; Humans; Length of Stay; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Recurrence; Risk Factors; Thiophenes; Ticlopidine; Treatment Outcome; Young Adult | 2015 |
A review of antithrombotic therapy and the rationale and design of the randomized edoxaban in patients with peripheral artery disease (ePAD) trial adding edoxaban or clopidogrel to aspirin after femoropopliteal endovascular intervention.
Topics: Aged; Angioplasty; Aspirin; Clopidogrel; Drug Therapy, Combination; Europe; Factor Xa Inhibitors; Female; Femoral Artery; Fibrinolytic Agents; Hemorrhage; Humans; Israel; Male; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Popliteal Artery; Pyridines; Research Design; Risk Factors; Stents; Thiazoles; Ticlopidine; Time Factors; Treatment Outcome; United States | 2015 |
Vertebrobasilar ectasia in patients with lacunar stroke: the secondary prevention of small subcortical strokes trial.
Topics: Aged; Basilar Artery; Clopidogrel; Dilatation, Pathologic; Double-Blind Method; Female; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Statistics, Nonparametric; Stroke, Lacunar; Ticlopidine; Tomography Scanners, X-Ray Computed | 2015 |
An open-label, randomized, controlled, multicenter study exploring two treatment strategies of rivaroxaban and a dose-adjusted oral vitamin K antagonist treatment strategy in subjects with atrial fibrillation who undergo percutaneous coronary intervention
Topics: Administration, Oral; Aged; Atrial Fibrillation; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Factor Xa Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Morpholines; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Rivaroxaban; Thiophenes; Ticlopidine; Treatment Outcome; Vitamin K | 2015 |
Intrinsic platelet reactivity before start with clopidogrel as predictor for on-clopidogrel platelet function and long-term clinical outcome.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Germany; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Predictive Value of Tests; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Left Ventricular Geometry on Transthoracic Echocardiogram and Prognosis after Lacunar Stroke: The SPS3 Trial.
Topics: Aged; Aspirin; Clopidogrel; Echocardiography; Female; Heart Ventricles; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Recurrence; Risk Factors; Secondary Prevention; Stroke, Lacunar; Ticlopidine | 2015 |
Ticagrelor increases endothelial progenitor cell level compared to clopidogrel in acute coronary syndromes: A prospective randomized study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Antigens, CD34; Body Mass Index; Clopidogrel; Endothelial Progenitor Cells; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
A prospective randomized evaluation of a pharmacogenomic approach to antiplatelet therapy among patients with ST-elevation myocardial infarction: the RAPID STEMI study.
Topics: Aged; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Testing; Genotype; Heterozygote; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prasugrel Hydrochloride; Prospective Studies; Ticlopidine | 2016 |
Discriminatory power of the intraoperative cell salvage use in the prediction of platelet and plasma transfusion in patients undergoing cardiac surgery.
Topics: Aged; Aorta; Aspirin; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Clopidogrel; Female; Humans; Male; Middle Aged; Operative Blood Salvage; Plasma; Platelet Transfusion; Ticlopidine | 2015 |
Study design of the influence of SErotonin inhibition on patients with RENAl impairment or diabetes undergoing drug-eluting stent implantation (SERENADE) study: A multicenter, open-label, prospective, randomized study.
Topics: Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Diabetes Mellitus; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Hepatic Insufficiency; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Renal Insufficiency, Chronic; Republic of Korea; Research Design; Serotonin Antagonists; Succinates; Ticlopidine | 2015 |
Frailty is associated with worse outcomes in non-ST-segment elevation acute coronary syndromes: Insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Aged, 80 and over; Clopidogrel; Double-Blind Method; Female; Frail Elderly; Health Surveys; Humans; Male; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prognosis; Ticlopidine; Treatment Outcome | 2016 |
Duration of Triple Therapy in Patients Requiring Oral Anticoagulation After Drug-Eluting Stent Implantation: The ISAR-TRIPLE Trial.
Topics: Aged; Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Does smoking habit affect the randomized comparison of 6 versus 24-month dual antiplatelet therapy duration? Insights from the PRODIGY trial.
Topics: Aged; Clopidogrel; Coronary Disease; Drug Administration Schedule; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Smoking; Stents; Ticlopidine; Time Factors | 2015 |
Stent Thrombosis and Dual Antiplatelet Therapy Interruption With Everolimus-Eluting Stents: Insights From the Xience V Coronary Stent System Trials.
Topics: Aged; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Combinations; Drug-Eluting Stents; Everolimus; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors; Withholding Treatment | 2015 |
Clopidogrel With Aspirin in Acute Minor Stroke or Transient Ischemic Attack (CHANCE) Trial: One-Year Outcomes.
Topics: Aged; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Ischemic Attack, Transient; Male; Middle Aged; Stroke; Ticlopidine; Treatment Outcome | 2015 |
Rationale and design of the RT-AF study: Combination of rivaroxaban and ticagrelor in patients with atrial fibrillation and coronary artery disease undergoing percutaneous coronary intervention.
Topics: Adenosine; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Hemorrhage; Humans; Percutaneous Coronary Intervention; Research Design; Rivaroxaban; Ticagrelor; Ticlopidine; Warfarin | 2015 |
Preoperative platelet aggregation predicts perioperative blood loss and rethoracotomy for bleeding in patients receiving dual antiplatelet treatment prior to coronary surgery.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug Combinations; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Hemorrhage; Premedication; Prognosis; Reoperation; Reproducibility of Results; Sensitivity and Specificity; Thoracic Surgery; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Comparison of therapy with Ticagrelor, Prasugrel or high Clopidogrel dose in PCI patients with high on treatment platelet reactivity and genotype variation. TRIPLETE RESET trial.
Topics: Adenosine; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Genetic Variation; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
CYP2C19 metabolizer status and clopidogrel efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) study.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2015 |
Ticagrelor versus clopidogrel in Asian patients with acute coronary syndrome: A retrospective analysis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Asian People; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
The effects of proton pump inhibition on patient-reported severity of dyspepsia when receiving dual anti-platelet therapy with clopidogrel and low-dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Dyspepsia; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine; Young Adult | 2015 |
Large early variation of residual platelet reactivity in Acute Coronary Syndrome patients treated with clopidogrel: results from Assessing Platelet Activity in Coronary Heart Disease (APACHE).
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Humans; Male; Platelet Aggregation; Platelet Count; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine; Treatment Outcome | 2015 |
[Twelve or thirty months of dual antiplatelet Therapy after drug-eluting stents. Results of the DAPT trial].
Topics: Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Revascularization; Piperazines; Platelet Aggregation Inhibitors; Postoperative Care; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Prospective Randomized Study of Sarpogrelate Versus Clopidogrel-based Dual Antiplatelet Therapies in Patients Undergoing Femoropopliteal Arterial Endovascular Interventions: Preliminary Results.
Topics: Aged; Arterial Occlusive Diseases; Clopidogrel; Female; Fibrinolytic Agents; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Peripheral Vascular Diseases; Popliteal Artery; Serotonin Antagonists; Succinates; Ticlopidine | 2015 |
A Randomized Study of the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Clopidogrel in Three Different CYP2C19 Genotype Groups of Healthy Japanese Subjects.
Topics: Adult; Clopidogrel; Cytochrome P-450 CYP2C19; Double-Blind Method; Genotype; Healthy Volunteers; Humans; Japan; Male; Maximum Tolerated Dose; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Safety; Ticlopidine; Young Adult | 2015 |
Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Alleles; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Genotype; Humans; Male; Middle Aged; Models, Biological; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2015 |
[Midterm follow-up outcomes of ticagrelor on acute ST segment elevation myocardial infarction undergoing emergency percutaneous coronary intervention].
Topics: Adenosine; Clopidogrel; Follow-Up Studies; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2015 |
Ankaferd blood stopper decreases postoperative bleeding and number of transfusions in patients treated with clopidogrel: a double-blind, placebo-controlled, randomized clinical trial.
Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Female; Hemostatics; Humans; Male; Middle Aged; Plant Extracts; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Premedication; Ticlopidine | 2015 |
Comparison of P2Y12 receptor inhibition by clopidogrel and prasugrel in patients undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Adult; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Is routine post-procedural anticoagulation warranted after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction? Insights from the HORIZONS-AMI trial.
Topics: Aged; Antithrombins; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Electrocardiography; Female; Fibrinolytic Agents; Follow-Up Studies; Heparin; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Care; Postoperative Complications; Prospective Studies; Recombinant Proteins; Secondary Prevention; ST Elevation Myocardial Infarction; Survival Rate; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2017 |
Assessment of efficacy of single dose acetylsalicylic acid over a 24-hour period.
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Ticagrelor Versus Clopidogrel in Black Patients With Stable Coronary Artery Disease: Prospective, Randomized, Open-Label, Multiple-Dose, Crossover Pilot Study.
Topics: Adenosine; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
Combination of factor Xa inhibition and antiplatelet therapy after stenting in patients with iliofemoral post-thrombotic venous obstruction.
Topics: Adolescent; Adult; Clopidogrel; Factor Xa Inhibitors; Female; Femoral Vein; Follow-Up Studies; Humans; Iliac Vein; Male; Middle Aged; Platelet Aggregation Inhibitors; Postthrombotic Syndrome; Rivaroxaban; Stents; Ticlopidine | 2016 |
Impact of chronic kidney disease on long-term ischemic and bleeding outcomes in medically managed patients with acute coronary syndromes: Insights from the TRILOGY ACS Trial.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Creatinine; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Renal Insufficiency, Chronic; Stroke; Ticlopidine; Treatment Outcome | 2016 |
Impact of Dabigatran versus Phenprocoumon on ADP Induced Platelet Aggregation in Patients with Atrial Fibrillation with or without Concomitant Clopidogrel Therapy (the Dabi-ADP-1 and Dabi-ADP-2 Trials).
Topics: Adenosine Diphosphate; Administration, Oral; Aged; Aged, 80 and over; Atrial Fibrillation; Clopidogrel; Dabigatran; Female; Follow-Up Studies; Humans; Male; Middle Aged; Phenprocoumon; Platelet Aggregation; Ticlopidine | 2015 |
Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding?
Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Drug Therapy, Combination; Female; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Platelet Transfusion; Postoperative Hemorrhage; Prospective Studies; Risk Assessment; Sensitivity and Specificity; Ticlopidine; Time Factors; Treatment Outcome; Withholding Treatment | 2015 |
Genetic and platelet function testing of antiplatelet therapy for percutaneous coronary intervention: the ARCTIC-GENE study.
Topics: Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke: CHANCE substudy.
Topics: Aged; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Quality of Life; Stroke; Ticlopidine | 2015 |
Temporal variability in the antiplatelet effects of clopidogrel and aspirin after elective drug-eluting stent implantation. An ADAPT-DES substudy.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Elective Surgical Procedures; Female; Germany; Humans; Male; Middle Aged; Observer Variation; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Purinergic P2Y12; Ticlopidine | 2015 |
Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in Japanese patients with stable coronary artery disease.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Substitution; Female; Genotype; Humans; Japan; Male; Middle Aged; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2015 |
Effects of CYP2C19 Polymorphism on Endothelial Function, Arterial Stiffness and Inflammation in Coronary Artery Disease Patients Under Clopidogrel Treatment.
Topics: Aged; Aged, 80 and over; Aspirin; Brachial Artery; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Endothelium, Vascular; Female; Genotype; Humans; Inflammation; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Real-Time Polymerase Chain Reaction; Ticlopidine; Vascular Stiffness | 2015 |
High Platelet Reactivity in Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: Randomised Controlled Trial Comparing Prasugrel and Clopidogrel.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Blood Platelets; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticlopidine; Treatment Outcome | 2015 |
Ticagrelor versus clopidogrel in Chinese patients with acute coronary syndrome: A pharmacodynamic analysis.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Follow-Up Studies; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin.
Topics: Administration, Oral; Adult; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Liver-Specific Organic Anion Transporter 1; Male; Organic Anion Transporters; Simvastatin; Ticlopidine; Young Adult | 2015 |
Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE.
Topics: Aged; Aspirin; Clopidogrel; Constriction, Pathologic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Intracranial Arterial Diseases; Ischemic Attack, Transient; Magnetic Resonance Angiography; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Stroke; Ticlopidine; Treatment Outcome | 2015 |
Antiplatelet efficacy of P2Y12 inhibitors (prasugrel, ticagrelor, clopidogrel) in patients treated with mild therapeutic hypothermia after cardiac arrest due to acute myocardial infarction.
Topics: Adenosine; Aged; Clopidogrel; Female; Heart Arrest; Humans; Hypothermia, Induced; Male; Middle Aged; Myocardial Infarction; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Agonists; Ticagrelor; Ticlopidine | 2016 |
Ticagrelor overcomes high platelet reactivity in patients with acute myocardial infarction or coronary artery in-stent restenosis: a randomized controlled trial.
Topics: Adenosine; Aged; Clopidogrel; Coronary Angiography; Coronary Restenosis; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
Stopping or continuing clopidogrel 12 months after drug-eluting stent placement: the OPTIDUAL randomized trial.
Topics: Acute Coronary Syndrome; Adult; Aftercare; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2016 |
Study design and rationale for Optimal aNtiplatelet pharmacotherapy guided by bedSIDE genetic or functional TESTing in elective percutaneous coronary intervention patients (ONSIDE TEST): a prospective, open-label, randomised parallel-group multicentre tri
Topics: Adolescent; Adult; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenomic Testing; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Research Design; Ticlopidine; Young Adult | 2016 |
The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin.
Topics: Adult; Age Factors; Amish; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Sex Factors; Ticlopidine; Time Factors | 2016 |
Ticagrelor vs. clopidogrel in Japanese, Korean and Taiwanese patients with acute coronary syndrome -- randomized, double-blind, phase III PHILO study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Asian People; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Humans; Japan; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Republic of Korea; Risk Factors; Stroke; Taiwan; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Pharmacodynamic Effects When Clopidogrel is Given Before Cangrelor Discontinuation.
Topics: Adenosine Monophosphate; Adult; Aged; Biological Availability; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Interactions; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2015 |
Does the Stenting Versus Aggressive Medical Therapy Trial Support Stenting for Subgroups With Intracranial Stenosis?
Topics: Angioplasty; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Constriction, Pathologic; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Middle Cerebral Artery; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Reduction Behavior; Stents; Stroke; Ticlopidine; Treatment Outcome; Vertebrobasilar Insufficiency | 2015 |
Intravenous Clopidogrel (MDCO-157) Compared with Oral Clopidogrel: The Randomized Cross-Over AMPHORE Study.
Topics: Administration, Oral; Adult; beta-Cyclodextrins; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Infusions, Intravenous; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Young Adult | 2016 |
Prasugrel in Clopidogrel Nonresponders Undergoing Percutaneous Coronary Intervention: The RECLOSE-3 Study (REsponsiveness to CLOpidogrel and StEnt Thrombosis).
Topics: Aged; Aged, 80 and over; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Resistance; Drug Substitution; Female; Historically Controlled Study; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Proportional Hazards Models; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Concomitant proton-pump inhibitor use, platelet activity, and clinical outcomes in patients with acute coronary syndromes treated with prasugrel versus clopidogrel and managed without revascularization: insights from the Targeted Platelet Inhibition to Cl
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Long-term outcomes for women versus men with unstable angina/non-ST-segment elevation myocardial infarction managed medically without revascularization: insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acu
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Clopidogrel; Coronary Angiography; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Combined clopidogrel-aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds.
Topics: Aged; Aspirin; Cerebral Cortex; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2015 |
The effect of cangrelor and access site on ischaemic and bleeding events: insights from CHAMPION PHOENIX.
Topics: Adenosine Monophosphate; Aged; Clopidogrel; Coronary Thrombosis; Double-Blind Method; Female; Femoral Artery; Graft Occlusion, Vascular; Hemorrhage; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Myocardial Revascularization; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Radial Artery; Stents; Ticlopidine; Treatment Outcome | 2016 |
Fixed and Modifiable Correlates of Drug-Eluting Stent Thrombosis From a Large All-Comers Registry: Insights From ADAPT-DES.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Patient Compliance; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Survival Analysis; Thrombosis; Ticlopidine; Ultrasonography, Interventional | 2015 |
The pharmacokinetic and pharmacodynamic interaction of clopidogrel and cilostazol in relation to CYP2C19 and CYP3A5 genotypes.
Topics: Administration, Oral; Adult; Area Under Curve; Cilostazol; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine; Young Adult | 2016 |
Comparative effect on platelet function of a fixed-dose aspirin and clopidogrel combination versus separate formulations in patients with coronary artery disease: A phase IV, multicenter, prospective, 4-week non-inferiority trial.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Combinations; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Treatment Outcome | 2016 |
Platelet inhibition with ticagrelor versus clopidogrel in Hispanic patients with stable coronary artery disease with or without diabetes mellitus.
Topics: Adenosine; Administration, Oral; Aged; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hispanic or Latino; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Regression Analysis; Risk Assessment; Severity of Illness Index; Ticagrelor; Ticlopidine; Treatment Outcome; United States | 2015 |
Comparison of antiplatelet effect and safety of clopidogrel napadisilate with clopidogrel bisulfate in stroke patients: multicenter, randomized, open-label, phase 4, non-inferiority clinical trial.
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2016 |
Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes and Chronic Obstructive Pulmonary Disease: An Analysis From the Platelet Inhibition and Patient Outcomes (PLATO) Trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Dyspnea; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Pulmonary Disease, Chronic Obstructive; Risk Assessment; Risk Factors; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Proton Pump Inhibitors, Platelet Reactivity, and Cardiovascular Outcomes After Drug-Eluting Stents in Clopidogrel-Treated Patients: The ADAPT-DES Study.
Topics: Aged; Blood Vessel Prosthesis Implantation; Clopidogrel; Drug Interactions; Drug-Eluting Stents; Female; Follow-Up Studies; Germany; Humans; Male; Middle Aged; Platelet Activation; Postoperative Complications; Prospective Studies; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome; United States | 2015 |
Antiplatelet Efficacy of Fixed-Dose Aspirin-Clopidogrel Combination in Patients with Stable Coronary Artery Disease Treated with Drug-Eluting Stent Implantation.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Combinations; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Treatment Outcome; Young Adult | 2015 |
Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.
Topics: Adenosine; Anti-Inflammatory Agents; Biomarkers; Blood Platelets; Chemotaxis, Leukocyte; Clopidogrel; Cytokines; Endotoxins; England; Female; Fibrin Fibrinogen Degradation Products; Humans; Inflammation; Inflammation Mediators; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2015 |
Sustained increase in platelet aggregation after the cessation of clopidogrel.
Topics: Arachidonic Acid; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Stents; Ticlopidine | 2016 |
Effects of CYP2C19 allelic variants on inhibition of platelet aggregation and major adverse cardiovascular events in Japanese patients with acute coronary syndrome: The PRASFIT-ACS study.
Topics: Acute Coronary Syndrome; Aged; Alleles; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Double-Blind Method; Female; Genotype; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenomic Variants; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2016 |
Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults.
Topics: Adult; Clopidogrel; Demography; Female; Genotype; Humans; Liver; Male; Middle Aged; Models, Biological; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Ticagrelor or prasugrel versus clopidogrel in elderly patients with an acute coronary syndrome: Optimization of antiplatelet treatment in patients 70 years and older--rationale and design of the POPular AGE study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
Association between Antiplatelet or Anticoagulant Drugs and Retinal or Subretinal Hemorrhage in the Comparison of Age-Related Macular Degeneration Treatments Trials.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Anticoagulants; Aspirin; Bevacizumab; Cardiovascular Diseases; Clopidogrel; Female; Fluorescein Angiography; Humans; Hypertension; Intravitreal Injections; Male; Odds Ratio; Platelet Aggregation Inhibitors; Ranibizumab; Retinal Hemorrhage; Risk Factors; Ticlopidine; Tomography, Optical Coherence; Vascular Endothelial Growth Factor A; Warfarin; Wet Macular Degeneration | 2016 |
Esomeprazole and rabeprazole did not reduce antiplatelet effects of aspirin/clopidogrel dual therapy in patients undergoing percutaneous coronary intervention: a prospective, randomized, case-control study.
Topics: Aged; Aspirin; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Male; Microfilament Proteins; Middle Aged; Percutaneous Coronary Intervention; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Rabeprazole; Ticlopidine | 2016 |
Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure: The CANOA Randomized Clinical Trial.
Topics: Aspirin; Cardiac Catheterization; Cardiac Surgical Procedures; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Headache Disorders, Secondary; Heart Septal Defects, Atrial; Humans; Male; Middle Aged; Migraine Disorders; Platelet Aggregation Inhibitors; Regression Analysis; Ticlopidine; Treatment Outcome | 2015 |
Achieved Blood Pressure and Outcomes in the Secondary Prevention of Small Subcortical Strokes Trial.
Topics: Aspirin; Blood Pressure; Blood Pressure Determination; Clopidogrel; Drug Therapy, Combination; Female; Humans; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Secondary Prevention; Severity of Illness Index; Stroke, Lacunar; Ticlopidine; Treatment Outcome | 2016 |
Efficacy of ex vivo autologous and in vivo platelet transfusion in the reversal of P2Y12 inhibition by clopidogrel, prasugrel, and ticagrelor: the APTITUDE study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Postoperative Hemorrhage; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Transplantation, Homologous; Treatment Outcome | 2015 |
The STIB score: a simple clinical test to predict clopidogrel resistance.
Topics: Aged; Angina, Stable; Angioplasty, Balloon, Coronary; Belgium; Biomarkers; Blood Platelets; Body Mass Index; Chi-Square Distribution; Clopidogrel; Comorbidity; Decision Support Techniques; Diabetes Complications; Drug Resistance; Female; Hemoglobins; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Obesity; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Testing; Predictive Value of Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Upstream clopidogrel, prasugrel, or ticagrelor for patients treated with primary angioplasty: Results of an angiographic randomized pilot study.
Topics: Adenosine; Aged; Angioplasty, Balloon, Coronary; Brazil; Clopidogrel; Coronary Angiography; Drug Administration Schedule; Emergency Medical Services; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Predictive Value of Tests; Prospective Studies; ST Elevation Myocardial Infarction; Thrombectomy; Ticagrelor; Ticlopidine; Time Factors; Time-to-Treatment; Treatment Outcome | 2016 |
Effects of dabigatran on the cellular and protein phase of coagulation in patients with coronary artery disease on dual antiplatelet therapy with aspirin and clopidogrel. Results from a prospective, randomised, double-blind, placebo-controlled study.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 Enzyme System; Dabigatran; Double-Blind Method; Electrodes; Female; Humans; Light; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thrombelastography; Thrombosis; Ticlopidine; Vitamin K | 2016 |
Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Long-Term Care; Male; Neoplasms; Non-ST Elevated Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2016 |
Impact of Hemoglobin A1c Levels on Residual Platelet Reactivity and Outcomes After Insertion of Coronary Drug-Eluting Stents (from the ADAPT-DES Study).
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Diabetes Mellitus; Drug-Eluting Stents; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2016 |
Platelet function and coagulation in patients with STEMI and peri-interventional clopidogrel plus heparin vs. prasugrel plus bivalirudin therapy (BRAVE 4 substudy).
Topics: Antithrombins; Clopidogrel; Drug Therapy, Combination; Female; Heparin; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Recombinant Proteins; Reproducibility of Results; Sensitivity and Specificity; Thrombelastography; Ticlopidine; Treatment Outcome | 2016 |
Incremental Value of the CRUSADE, ACUITY, and HAS-BLED Risk Scores for the Prediction of Hemorrhagic Events After Coronary Stent Implantation in Patients Undergoing Long or Short Duration of Dual Antiplatelet Therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Assessment; Stents; Ticlopidine | 2015 |
Effects of P2Y12 receptor inhibition with or without aspirin on hemostatic system activation: a randomized trial in healthy subjects.
Topics: Adenosine; Adolescent; Adult; Area Under Curve; Aspirin; Austria; beta-Thromboglobulin; Biomarkers; Bleeding Time; Blood Platelets; Clopidogrel; Double-Blind Method; Healthy Volunteers; Hemostasis; Humans; Male; Middle Aged; Peptide Fragments; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prothrombin; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; ROC Curve; Ticagrelor; Ticlopidine; Time Factors; Young Adult | 2016 |
Efficacy of Clopidogrel and Clinical Outcome When Clopidogrel Is Coadministered With Atorvastatin and Lansoprazole: A Prospective, Randomized, Controlled Trial.
Topics: Acute Coronary Syndrome; Adult; Aged; Atorvastatin; Clopidogrel; Drug Interactions; Drug-Eluting Stents; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lansoprazole; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Polypharmacy; Prospective Studies; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2015 |
ADP receptor antagonists in patients with acute myocardial infarction complicated by cardiogenic shock: a post hoc IABP-SHOCK II trial subgroup analysis.
Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Shock, Cardiogenic; Thiophenes; Ticlopidine | 2016 |
P-Glycoprotein Polymorphism C3435T Is Associated with Dose-Adjusted Clopidogrel and 2-Oxo-Clopidogrel Concentration.
Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cross-Sectional Studies; Female; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2016 |
Pre-PCI medication using clopidogrel and ticagrelor in the treatment of patients with acute myocardial infarction.
Topics: Adenosine; Aged; Clopidogrel; Combined Modality Therapy; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
Evaluation of the incremental prognostic value of the combination of CYP2C19 poor metabolizer status and ABCB1 3435 TT polymorphism over conventional risk factors for cardiovascular events after drug-eluting stent implantation in East Asians.
Topics: Aged; Aged, 80 and over; Asia, Eastern; Asian People; Aspirin; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Mutation; Percutaneous Coronary Intervention; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Prognosis; Risk Factors; Ticlopidine | 2016 |
PREDICT score and CYP2C19 polymorphism independently predict lack of efficacy of clopidogrel in cardiology patients.
Topics: Clopidogrel; Coronary Vessels; Cytochrome P-450 CYP2C19; Drug Resistance; Humans; Multivariate Analysis; Platelet Aggregation; Polymorphism, Genetic; Stents; Ticlopidine | 2016 |
VERifyNow in DIabetes high-on-treatment platelet reactivity: a pharmacodynamic study on switching from clopidogrel to prasugrel.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Single-Blind Method; Ticlopidine; Treatment Outcome | 2015 |
Antiplatelet Therapy in Carotid Artery Stenting and Carotid Endarterectomy in the Asymptomatic Carotid Surgery Trial-2.
Topics: Aspirin; Carotid Artery, Common; Carotid Stenosis; Clopidogrel; Dose-Response Relationship, Drug; Endarterectomy, Carotid; Follow-Up Studies; Humans; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stents; Stroke; Ticlopidine; Treatment Outcome | 2016 |
Outcomes of Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention Receiving an Oral Anticoagulant and Dual Antiplatelet Therapy: A Comparison of Clopidogrel Versus Prasugrel From the TRANSLATE-ACS Study.
Topics: Administration, Oral; Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome; United States | 2015 |
Differences in Whole Blood Platelet Aggregation at Baseline and in Response to Aspirin and Aspirin Plus Clopidogrel in Patients With Versus Without Chronic Kidney Disease.
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Renal Insufficiency, Chronic; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Ticagrelor vs clopidogrel followed by ticagrelor re-loading in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: A randomized, pharmacodynamic comparison.
Topics: Adenosine; Biomarkers; Blood Platelets; Clopidogrel; Electrocardiography; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticagrelor; Ticlopidine | 2016 |
Protocol for the comparison of triflusal and clopidogrel in secondary prevention of stroke based on cytochrome P450 2C19 genotyping (MASETRO study): A multicenter, randomized, open-label, parallel-group trial.
Topics: Brain Ischemia; Cerebral Hemorrhage; Chemoprevention; Clopidogrel; Cytochrome P-450 CYP2C19; Follow-Up Studies; Genotype; Humans; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Recurrence; Salicylates; Secondary Prevention; Single-Blind Method; Stroke; Ticlopidine; Treatment Outcome | 2016 |
Secondary prevention of cardiogenic arterial thromboembolism in the cat: The double-blind, randomized, positive-controlled feline arterial thromboembolism; clopidogrel vs. aspirin trial (FAT CAT).
Topics: Animals; Aspirin; Cat Diseases; Cats; Clopidogrel; Double-Blind Method; Male; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine | 2015 |
Randomized Comparison of Different Thienopyridine Loading Strategies in Patients Undergoing Elective Coronary Intervention: The ExcelsiorLOAD Trial.
Topics: Aged; Blood Platelets; Clopidogrel; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Premedication; Prospective Studies; Ticlopidine | 2016 |
Implications of ischaemic area at risk and mode of reperfusion in ST-elevation myocardial infarction.
Topics: Aged; Clopidogrel; Comparative Effectiveness Research; Electrocardiography; Enoxaparin; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Patient Outcome Assessment; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Survival Analysis; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Relationship Between Early and Late Nonsustained Ventricular Tachycardia and Cardiovascular Death in Patients With Acute Coronary Syndrome in the Platelet Inhibition and Patient Outcomes (PLATO) Trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Biomarkers; Cause of Death; Clopidogrel; Death, Sudden, Cardiac; Electrocardiography; Female; Humans; Incidence; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Tachycardia, Ventricular; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Changes in CYP2C19 enzyme activity evaluated by the [(13)C]-pantoprazole breath test after co-administration of clopidogrel and proton pump inhibitors following percutaneous coronary intervention and correlation to platelet reactivity.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Blood Platelets; Breath Tests; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Esomeprazole; Humans; Omeprazole; Pantoprazole; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Ranitidine; Ticlopidine | 2016 |
Pivotal Bioequivalence Study of Clopacin®, a Generic Formulation of Clopidogrel 75 mg Film-Coated Tablets.
Topics: Adult; Area Under Curve; Chromatography, High Pressure Liquid; Clopidogrel; Cross-Over Studies; Drugs, Generic; Half-Life; Humans; Male; Platelet Aggregation Inhibitors; Tandem Mass Spectrometry; Therapeutic Equivalency; Ticlopidine | 2016 |
A head-to-head pharmacodynamic comparison of prasugrel vs. ticagrelor after switching from clopidogrel in patients with coronary artery disease: results of a prospective randomized study.
Topics: Adenosine; Blood Platelets; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Ticagrelor; Ticlopidine | 2016 |
Safety and efficacy of ticagrelor and clopidogrel in primary percutaneous coronary intervention.
Topics: Adenosine; Aged; Clopidogrel; Combined Modality Therapy; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Six Versus 12 Months of Dual Antiplatelet Therapy After Implantation of Biodegradable Polymer Sirolimus-Eluting Stent: Randomized Substudy of the I-LOVE-IT 2 Trial.
Topics: Absorbable Implants; Aged; Antibiotics, Antineoplastic; Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Sirolimus; Ticlopidine | 2016 |
Comparison of the influence of ticagrelor and clopidogrel on inflammatory biomarkers and vascular endothelial function for patients with ST-segment elevation myocardial infarction receiving emergency percutaneous coronary intervention: study protocol for
Topics: Adenosine; Biomarkers; C-Reactive Protein; CD40 Ligand; Clinical Protocols; Clopidogrel; Endothelium, Vascular; Humans; Myocardial Infarction; P-Selectin; Percutaneous Coronary Intervention; Prospective Studies; Purinergic P2Y Receptor Antagonists; Sample Size; Ticagrelor; Ticlopidine | 2016 |
Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Patients With Low-Risk ACS Undergoing Ad Hoc PCI.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Aged; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Preoperative Care; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome; Troponin | 2016 |
[Argatroban, Aspirin, and Clopidogrel Combination Therapy for Acute Penetrating Artery Infarction: A Pilot Study].
Topics: Acute Disease; Aged; Arginine; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Infarction; Male; Middle Aged; Pilot Projects; Pipecolic Acids; Platelet Aggregation Inhibitors; Prospective Studies; Stroke; Sulfonamides; Ticlopidine; Treatment Outcome | 2016 |
Effectiveness of platelet inhibition on major adverse cardiac events in non-cardiac surgery after percutaneous coronary intervention: a prospective cohort study.
Topics: Aged; Aspirin; Cardiomyopathy, Dilated; Clopidogrel; Cohort Studies; Female; Heart Diseases; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Surgical Procedures, Operative; Ticlopidine; Treatment Outcome; Troponin I | 2016 |
Influence of smoking on the antiplatelet effect of clopidogrel differs according to clopidogrel dose: Insights from the GRAVITAS trial.
Topics: Aged; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug-Eluting Stents; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Smoking; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Ticlopidine; Treatment Outcome | 2016 |
Rationale and design of POPular-TAVI: antiPlatelet therapy fOr Patients undergoing Transcatheter Aortic Valve Implantation.
Topics: Administration, Oral; Aortic Valve Stenosis; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Europe; Follow-Up Studies; Humans; Incidence; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Prospective Studies; Survival Rate; Thromboembolism; Ticlopidine; Time Factors; Transcatheter Aortic Valve Replacement; Treatment Outcome | 2016 |
Morphological classification of penetrating artery pontine infarcts and association with risk factors and prognosis: The SPS3 trial.
Topics: Antihypertensive Agents; Aspirin; Cerebral Infarction; Clopidogrel; Constriction, Pathologic; Double-Blind Method; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Observer Variation; Platelet Aggregation Inhibitors; Pons; Prognosis; Recurrence; Reproducibility of Results; Risk Factors; Stroke, Lacunar; Ticlopidine; Treatment Outcome | 2016 |
Durable Clinical Effectiveness With Paclitaxel-Eluting Stents in the Femoropopliteal Artery: 5-Year Results of the Zilver PTX Randomized Trial.
Topics: Adult; Aged; Angioplasty; Anticoagulants; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Combined Modality Therapy; Disease Progression; Disease-Free Survival; Drug-Eluting Stents; Equipment Failure; Female; Femoral Artery; Follow-Up Studies; Humans; Intermittent Claudication; Ischemia; Male; Middle Aged; Paclitaxel; Popliteal Artery; Recurrence; Stents; Ticlopidine; Vascular Patency | 2016 |
Effect of Modifying Antiplatelet Treatment to Ticagrelor in High-Risk Coronary Patients With Low Response to Clopidogrel (MATTIS).
Topics: Adenosine; Aged; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine; Troponin | 2016 |
Spontaneous MI After Non-ST-Segment Elevation Acute Coronary Syndrome Managed Without Revascularization: The TRILOGY ACS Trial.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Global Health; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Risk Assessment; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Impact of proton pump inhibitors on clinical outcomes in patients treated with a 6- or 24-month dual-antiplatelet therapy duration: Insights from the PROlonging Dual-antiplatelet treatment after Grading stent-induced Intimal hyperplasia studY trial.
Topics: Administration, Oral; Aged; Aspirin; Clopidogrel; Coronary Vessels; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Hyperplasia; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stents; Ticlopidine; Time Factors; Treatment Outcome; Tunica Intima | 2016 |
A randomized trial to compare the safety of rivaroxaban vs aspirin in addition to either clopidogrel or ticagrelor in acute coronary syndrome: The design of the GEMINI-ACS-1 phase II study.
Topics: Acute Coronary Syndrome; Adenosine; Adolescent; Adult; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Factor Xa Inhibitors; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Rivaroxaban; Ticagrelor; Ticlopidine; Treatment Outcome; Young Adult | 2016 |
Treatment Effect of Clopidogrel Plus Aspirin Within 12 Hours of Acute Minor Stroke or Transient Ischemic Attack.
Topics: Aged; Aspirin; Chi-Square Distribution; China; Clopidogrel; Disease Progression; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemorrhage; Humans; Ischemic Attack, Transient; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Recurrence; Risk Factors; Secondary Prevention; Severity of Illness Index; Stroke; Ticlopidine; Time Factors; Time-to-Treatment; Treatment Outcome | 2016 |
The evaluation of clopidogrel use in perioperative general surgery patients: a prospective randomized controlled trial.
Topics: Aged; Blood Loss, Surgical; Clopidogrel; Elective Surgical Procedures; Female; General Surgery; Hospital Mortality; Humans; Intraoperative Complications; Length of Stay; Male; Middle Aged; Perioperative Care; Postoperative Hemorrhage; Prognosis; Prospective Studies; Risk Assessment; Surgical Procedures, Operative; Survival Rate; Ticlopidine; Treatment Outcome | 2016 |
Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Resistance; Drug Therapy, Combination; Female; Flow Cytometry; Gene Frequency; Haplotypes; Humans; Insulin Receptor Substrate Proteins; Male; Middle Aged; P-Selectin; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Diabetes mellitus, CYP2C19 genotype, and response to escalating doses of clopidogrel. Insights from the ELEVATE-TIMI 56 Trial.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Genotype; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Assessment of Ticagrelor Versus Clopidogrel Treatment in Patients With ST-elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
Topics: Adenosine; Aged; Chi-Square Distribution; China; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recurrence; Risk Factors; ST Elevation Myocardial Infarction; Stroke; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy.
Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyspepsia; Female; Gastrointestinal Hemorrhage; Humans; Intestinal Obstruction; Intestinal Perforation; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Omeprazole; Pain; Peptic Ulcer; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Stroke; Ticlopidine | 2016 |
Comparison of dual antiplatelet therapy prescribed as one-pill versus two-pill regimen. A pooled analysis of individual patient data from the three MR-CAPCIS trials.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Combinations; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Republic of Korea; Ticlopidine | 2016 |
Effect of prior clopidogrel use on outcomes in medically managed acute coronary syndrome patients.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemorrhage; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Role of stent type and of duration of dual antiplatelet therapy in patients with chronic kidney disease undergoing percutaneous coronary interventions. Is bare metal stent implantation still a justifiable choice? A post-hoc analysis of the all comer PRODI
Topics: Aged; Aged, 80 and over; Aspirin; Clinical Decision-Making; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Metals; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Renal Insufficiency, Chronic; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Salts of Clopidogrel: Investigation to Ensure Clinical Equivalence: A 12-Month Randomized Clinical Trial.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Clopidogrel; Drug Compounding; Drugs, Generic; Female; Greece; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Secondary Prevention; Stroke; Therapeutic Equivalency; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Ticagrelor Improves Peripheral Arterial Function in Acute Coronary Syndrome Patients: Relationship With Adenosine Plasma Level.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Arteries; Aspirin; Biomarkers; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Extremities; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peripheral Arterial Disease; Prospective Studies; Severity of Illness Index; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Anti-platelet drugs attenuate the expansion of circulating CD14highCD16+ monocytes under pro-inflammatory conditions.
Topics: Adult; Aspirin; Biomarkers; C-Reactive Protein; Cell Proliferation; Clopidogrel; Cytokines; Female; Flow Cytometry; GPI-Linked Proteins; Humans; Immunologic Factors; Inflammation; Inflammation Mediators; Influenza Vaccines; Lipopolysaccharide Receptors; London; Male; Monocytes; P-Selectin; Phenotype; Platelet Aggregation Inhibitors; Receptors, IgG; Ticlopidine; Vaccination | 2016 |
One-quarter standard-dose ticagrelor better than standard-dose clopidogrel in Chinese patients with stable coronary artery disease: A randomized, single-blind, crossover clinical study.
Topics: Adenosine; Aged; China; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation; Single-Blind Method; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Inferiority of ticagrelor in the PHILO trial: Play of chance in East Asians or nightmare confirmation of PLATO-USA?
Topics: Acute Coronary Syndrome; Adenosine; Asian People; Aspirin; Black People; Clopidogrel; Hemorrhage; Humans; Japan; Ticagrelor; Ticlopidine; Treatment Outcome; United States; White People | 2016 |
Impact of Anemia on Platelet Reactivity and Ischemic and Bleeding Risk: From the Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents Study.
Topics: Aged; Anemia; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Europe; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk Assessment; Risk Factors; Survival Rate; Ticlopidine; United States | 2016 |
Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy.
Topics: ADAMTS13 Protein; Adult; Autoantibodies; Autoimmune Diseases; Clopidogrel; Cohort Studies; Cross-Sectional Studies; Digestive System Diseases; Female; Fever; France; Genotype; HIV Infections; Humans; Infections; Male; Middle Aged; Mutation; Neoplasms; Nervous System Diseases; Pregnancy; Pregnancy Complications; Prevalence; Purpura, Thrombocytopenic, Idiopathic; Purpura, Thrombotic Thrombocytopenic; Registries; Risk Factors; Sex Factors; Ticlopidine; Transplantation | 2016 |
Adjunctive loading dose of cilostazol in preventing periprocedural myocardial infarction.
Topics: Aged; Aspirin; Biomarkers; Chi-Square Distribution; China; Cilostazol; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Incidence; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk Factors; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
[Prevalence of acetylsalicylic acid (ASA) - low response in vascular surgery].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Arterial Occlusive Diseases; Aspirin; Carotid Stenosis; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Leukocyte Count; Long-Term Care; Male; Middle Aged; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Postoperative Complications; Risk Factors; Ticlopidine | 2016 |
Efficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2016 |
Prasugrel 5 mg inhibits platelet P-selectin and GPIIb-IIIa expression in very elderly and non elderly: results from the GENERATIONS trial, a pharmacodynamic study in stable CAD patients.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Humans; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Ticlopidine | 2016 |
Assessment of platelet function in healthy cats in response to commonly prescribed antiplatelet drugs using three point-of-care platelet function tests.
Topics: Administration, Oral; Animals; Aspirin; Blood Coagulation Tests; Blood Platelets; Cats; Clopidogrel; Female; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Ticlopidine | 2017 |
Comparison of the antiplatelet effect of clopidogrel benzene sulfonate and clopidogrel hydrogen sulfate in stable coronary heart disease.
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Combinations; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Association Between Very Low Levels of High-Density Lipoprotein Cholesterol and Long-term Outcomes of Patients With Acute Coronary Syndrome Treated Without Revascularization: Insights From the TRILOGY ACS Trial.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Biomarkers; Cholesterol, HDL; Clopidogrel; Down-Regulation; Drug Therapy, Combination; Dyslipidemias; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Non-ST Elevated Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Design and rationale for the Effects of Ticagrelor and Clopidogrel in Patients with Peripheral Artery Disease (EUCLID) trial.
Topics: Adenosine; Aged; Ankle Brachial Index; Clopidogrel; Disease Progression; Female; Humans; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Clopidogrel treatment may associate with worsening of endothelial function and development of new digital ulcers in patients with systemic sclerosis: results from an open label, proof of concept study.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Animals; Clopidogrel; Endothelium, Vascular; Female; Fingers; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Proof of Concept Study; Purinergic P2Y Receptor Antagonists; Scleroderma, Systemic; Serotonin; Skin Ulcer; Ticlopidine; Vascular Cell Adhesion Molecule-1 | 2016 |
6-Month Versus 12-Month Dual-Antiplatelet Therapy Following Long Everolimus-Eluting Stent Implantation: The IVUS-XPL Randomized Clinical Trial.
Topics: Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Everolimus; Hemorrhage; Humans; Intention to Treat Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Republic of Korea; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Impaired biological response to aspirin in therapeutic hypothermia comatose patients resuscitated from out-of-hospital cardiac arrest.
Topics: Acute Coronary Syndrome; Administration, Intravenous; Administration, Oral; Adult; Aged; Aspirin; Cardiopulmonary Resuscitation; Clopidogrel; Coma; Female; Humans; Hypothermia, Induced; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Ticlopidine | 2016 |
[The possibility of selecting optimal antiplatelet therapy in patients with coronary heart disease in terms of CYP2C19 polymorphism].
Topics: Aspirin; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Ticlopidine | 2016 |
Effect of Smoking Status on Clinical Outcome and Efficacy of Clopidogrel in Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Disease-Free Survival; Female; Hospital Mortality; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Prospective Studies; Smoking; Survival Rate; Ticlopidine | 2016 |
Infarct Size Following Treatment With Second- Versus Third-Generation P2Y12 Antagonists in Patients With Multivessel Coronary Disease at ST-Segment Elevation Myocardial Infarction in the CvLPRIT Study.
Topics: Adenosine; Aged; Clopidogrel; Coronary Angiography; Coronary Stenosis; Drug Administration Schedule; Female; Humans; Magnetic Resonance Angiography; Male; Microvessels; Middle Aged; Myocardial Revascularization; Organ Size; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Risks and Benefits of Dual Antiplatelet Therapy Beyond 12 Months After Coronary Stenting: A Prospective Randomized Cohort Study.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone.
Topics: Administration, Oral; Adult; Area Under Curve; Biotransformation; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Drug Administration Schedule; Drug Interactions; Female; Finland; Genotype; Half-Life; Healthy Volunteers; Humans; Hypoglycemic Agents; Male; Metabolic Clearance Rate; Pharmacogenomic Variants; Phenotype; Pioglitazone; Platelet Aggregation Inhibitors; Risk Assessment; Thiazolidinediones; Ticlopidine; Young Adult | 2016 |
Carotid Endarterectomy on Antiplatelet Agents in the Era of Point-of-Care Testing.
Topics: Aged; Arizona; Blood Loss, Surgical; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Female; Humans; Male; Platelet Aggregation Inhibitors; Point-of-Care Testing; Postoperative Hemorrhage; Prevalence; Risk Factors; Survival Rate; Ticlopidine; Treatment Outcome | 2016 |
Ticagrelor versus prasugrel in patients with high on-clopidogrel treatment platelet reactivity after PCI: The ISAR-ADAPT-PF study.
Topics: Adenosine; Adenosine Diphosphate; Aged; Blood Platelets; Clopidogrel; Comorbidity; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Efficacy and Safety of Vinpocetine as Part of Treatment for Acute Cerebral Infarction: A Randomized, Open-Label, Controlled, Multicenter CAVIN (Chinese Assessment for Vinpocetine in Neurology) Trial.
Topics: Aged; Anticoagulants; Aspirin; Cerebral Infarction; Cerebrovascular Circulation; China; Clopidogrel; Cognition; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Platelet Aggregation Inhibitors; Quality of Life; Stroke; Ticlopidine; Ultrasonography, Doppler, Transcranial; Vinca Alkaloids | 2016 |
Drug Interaction Between Clopidogrel and Ranitidine or Omeprazole in Stable Coronary Artery Disease: A Double-Blind, Double Dummy, Randomized Study.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Ranitidine; Ticlopidine | 2016 |
Impact of glycoprotein IIb/IIIa inhibitors on the efficacy and safety of ticagrelor compared with clopidogrel in patients with acute coronary syndromes: Analysis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial.
Topics: Abciximab; Acute Coronary Syndrome; Adenosine; Aged; Antibodies, Monoclonal; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Eptifibatide; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Peptides; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2Y Receptor Antagonists; Stroke; Thrombosis; Ticagrelor; Ticlopidine; Tirofiban; Tyrosine | 2016 |
Rationale and design of the Affordability and Real-world Antiplatelet Treatment Effectiveness after Myocardial Infarction Study (ARTEMIS): A multicenter, cluster-randomized trial of P2Y12 receptor inhibitor copayment reduction after myocardial infarction.
Topics: Adenosine; Clopidogrel; Cost Sharing; Drug Costs; Financial Support; Health Care Costs; Health Expenditures; Humans; Logistic Models; Medication Adherence; Mortality; Multivariate Analysis; Myocardial Infarction; Purinergic P2Y Receptor Antagonists; Recurrence; Secondary Prevention; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Variation in Patient Profiles and Outcomes in US and Non-US Subgroups of the Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition (CHAMPION) PHOENIX Trial.
Topics: Adenosine Monophosphate; Aged; Brazil; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Double-Blind Method; Europe; Female; Hemorrhage; Humans; Intention to Treat Analysis; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; New Zealand; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Thailand; Ticlopidine; Time Factors; Treatment Outcome; United States | 2016 |
[The use of prasugrel in STEMI and NSTEMI: TRITON TIMI 38 study and subgroup analyses].
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2015 |
[TRILOGY-ACS and ACCOAST trial from an expert's perspective].
Topics: Acute Coronary Syndrome; Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Prasugrel Hydrochloride; Ticlopidine | 2015 |
A randomized trial assessing the impact of three different glycoprotein IIb/IIIa antagonists on glycoprotein IIb/IIIa platelet receptor inhibition and clinical endpoints in patients with acute coronary syndromes.
Topics: Abciximab; Acute Coronary Syndrome; Adenosine; Aged; Antibodies, Monoclonal; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Eptifibatide; Female; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; New South Wales; Peptides; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticagrelor; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Tyrosine | 2016 |
Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results.
Topics: Acute Coronary Syndrome; Aged; Aspirin; China; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Fatty Alcohols; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Association Between CYP2C19 Loss-of-Function Allele Status and Efficacy of Clopidogrel for Risk Reduction Among Patients With Minor Stroke or Transient Ischemic Attack.
Topics: Aged; Alleles; Asian People; Aspirin; China; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Follow-Up Studies; Gene Silencing; Genotype; Hemorrhage; Heterozygote; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Drug Substitution; Female; Gene Expression Regulation; Humans; Male; MicroRNAs; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2016 |
Effects of Prasugrel Versus Clopidogrel on Coronary Microvascular Function in Patients Undergoing Elective PCI.
Topics: Clopidogrel; Coronary Circulation; Humans; Microcirculation; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2016 |
A Cost-Effectiveness Analysis of Clopidogrel for Patients with Non-ST-Segment Elevation Acute Coronary Syndrome in China.
Topics: Acute Coronary Syndrome; Aspirin; China; Clopidogrel; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Female; Humans; Male; Markov Chains; Middle Aged; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Ticlopidine | 2016 |
Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke: Clopidogrel Plus Aspirin Versus Aspirin Alone.
Topics: Aged; Aspirin; Atherosclerosis; Brain; Brain Ischemia; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2016 |
The curative effect comparison of two kinds of therapeutic regimens on decreasing the relative intensity of microembolic signal in CLAIR trial.
Topics: Aspirin; Brain Ischemia; Carotid Stenosis; Cerebral Arterial Diseases; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Intracranial Embolism; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Single-Blind Method; Stroke; Ticlopidine; Treatment Outcome | 2016 |
Rationale and design of the SAFE-A study: SAFety and Effectiveness trial of Apixaban use in association with dual antiplatelet therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention.
Topics: Aspirin; Atrial Fibrillation; Blood Transfusion; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Factor Xa Inhibitors; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Pyrazoles; Pyridones; Stroke; Ticlopidine | 2017 |
Effect of long-term adherence to clopidogrel on the VASP-PRI after elective coronary stent implantation: a randomized controlled study.
Topics: Aged; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Medication Adherence; Microfilament Proteins; Middle Aged; Percutaneous Coronary Intervention; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis.
Topics: Aged; Asian People; Aspirin; Carboxylic Ester Hydrolases; Clopidogrel; Constriction, Pathologic; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Ischemia; Male; Middle Aged; Mutation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine; Treatment Outcome | 2016 |
The Prognostic Value of ADP-Induced Platelet Aggregation for Bleeding Complications in Low - Intermediate Risk Patients with Acute Coronary Syndrome Taking Clopidogrel After Percutaneous Coronary Intervention.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Clopidogrel; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Prognosis; Risk Factors; Ticlopidine | 2017 |
Similar Impact of Clopidogrel or Ticagrelor on Carotid Atherosclerotic Plaque Inflammation.
Topics: Adenosine; Aged; Anti-Inflammatory Agents; Carotid Arteries; Carotid Stenosis; Clopidogrel; Female; Fluorodeoxyglucose F18; Humans; Inflammation; Male; Middle Aged; Plaque, Atherosclerotic; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Radiopharmaceuticals; Republic of Korea; Severity of Illness Index; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Impact of oral P2Y12 inhibitors on residual thrombus burden and reperfusion indexes in patients with ST-segment elevation myocardial infarction.
Topics: Abciximab; Adenosine; Administration, Oral; Aged; Aged, 80 and over; Antibodies, Monoclonal; Clopidogrel; Coronary Angiography; Electrocardiography; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Reperfusion; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Stents; Thrombectomy; Thrombosis; Ticagrelor; Ticlopidine; Tomography, Optical Coherence | 2016 |
Dual Antiplatelet Therapy and Outcomes in Patients With Atrial Fibrillation and Acute Coronary Syndromes Managed Medically Without Revascularization: Insights From the TRILOGY ACS Trial.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Atrial Fibrillation; Chi-Square Distribution; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Linear Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Consistent Reduction in Periprocedural Myocardial Infarction With Cangrelor as Assessed by Multiple Definitions: Findings From CHAMPION PHOENIX (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition).
Topics: Adenosine Monophosphate; Aged; Clopidogrel; Disease Management; Double-Blind Method; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Perioperative Care; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2016 |
Changes in P2Y12 reaction units after switching treatments from prasugrel to clopidogrel in Japanese patients with acute coronary syndrome followed by elective coronary stenting.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Japan; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Prosthesis Implantation; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic; Stents; Ticlopidine | 2017 |
Randomized evaluation of short-term dual antiplatelet therapy in patients with acute coronary syndrome treated with the COMBO dual therapy stent: rationale and design of the REDUCE trial.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Cause of Death; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Graft Occlusion, Vascular; Hemorrhage; Humans; Mortality; Myocardial Infarction; Myocardial Revascularization; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stroke; Thrombosis; Ticagrelor; Ticlopidine; Time Factors | 2016 |
Health-related quality of life outcomes with prasugrel among medically managed non-ST-segment elevation acute coronary syndrome patients: Insights from the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syn
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Health Status; Humans; Linear Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Quality of Life; Ticlopidine | 2016 |
Efficacy of Leflunomide, Telmisartan, and Clopidogrel for Immunoglobulin A Nephropathy: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Benzimidazoles; Benzoates; Blood Pressure; China; Clopidogrel; Creatinine; Female; Glomerular Filtration Rate; Glomerulonephritis, IGA; Humans; Isoxazoles; Kidney Function Tests; Leflunomide; Male; Middle Aged; Prospective Studies; Telmisartan; Ticlopidine; Treatment Outcome; Uric Acid; Young Adult | 2016 |
The Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel in Healthy Japanese Volunteers.
Topics: Adult; Aged; Area Under Curve; Asian People; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Female; Genotype; Healthy Volunteers; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Single-Blind Method; Ticlopidine; Young Adult | 2016 |
Thienopyridine reloading in clopidogrel-loaded patients undergoing percutaneous coronary interventions: The PRAISE study.
Topics: Aged; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Pyridines; Ticlopidine | 2016 |
Impact of Sex on 2-Year Clinical Outcomes in Patients Treated With 6-Month or 24-Month Dual-Antiplatelet Therapy Duration: A Pre-Specified Analysis From the PRODIGY Trial.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemorrhage; Humans; Italy; Male; Middle Aged; Myocardial Infarction; Neointima; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Assessment; Risk Factors; Sex Factors; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Pharmacodynamic effects of a new fixed-dose clopidogrel-aspirin combination compared with separate administration of clopidogrel and aspirin in patients treated with coronary stents: The ACCEL-COMBO trial.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Comorbidity; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombelastography; Ticlopidine; Treatment Outcome | 2017 |
Prasugrel versus clopidogrel in acute coronary syndromes treated with PCI: Effects on clinical outcome according to culprit artery location.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Vessels; Double-Blind Method; Female; Humans; Male; Middle Aged; Mortality; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2016 |
High-dose clopidogrel versus ticagrelor for treatment of acute coronary syndromes after percutaneous coronary intervention in CYP2C19 intermediate or poor metabolizers: a prospective, randomized, open-label, single-centre trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; China; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Monitoring; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Long Term Adverse Effects; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenomic Testing; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Abnormal glucose regulation increases stroke risk in minor ischemic stroke or TIA.
Topics: Aged; Aspirin; Blood Glucose; Brain Ischemia; Clopidogrel; Diabetes Complications; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Risk; Stroke; Ticlopidine; Treatment Outcome | 2016 |
Clopidogrel Versus Ticagrelor for Antiplatelet Maintenance in Diabetic Patients Treated With Percutaneous Coronary Intervention: Results of the CLOTILDIA Study (Clopidogrel High Dose Versus Ticagrelor for Antiplatelet Maintenance in Diabetic Patients).
Topics: Adenosine; Clopidogrel; Coronary Artery Disease; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2016 |
Six Versus Twelve Months Clopidogrel Therapy After Drug-Eluting Stenting in Patients With Acute Coronary Syndrome: An ISAR-SAFE Study Subgroup Analysis.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug-Eluting Stents; Follow-Up Studies; Hemorrhage; Humans; Middle Aged; Ticlopidine; Time Factors | 2016 |
Clinical outcomes of dual antiplatelet therapy after implantation of drug-eluting stents in patients with different cardiovascular risk factors.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Republic of Korea; Risk Factors; Sirolimus; Ticlopidine; Time Factors | 2017 |
Concomitant Use of Proton-Pump Inhibitors and Clopidogrel Increases the Risk of Adverse Outcomes in Patients With Ischemic Stroke Carrying Reduced-Function CYP2C19*2.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Proton Pump Inhibitors; Risk Factors; Stroke; Ticlopidine | 2018 |
Prevalence and Predictors of Early Discontinuation of Dual-Antiplatelet Therapy After Drug-Eluting Stent Implantation in Korean Population.
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Patient Compliance; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prevalence; Republic of Korea; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors; Withholding Treatment; Young Adult | 2016 |
A randomised trial on platelet function-guided de-escalation of antiplatelet treatment in ACS patients undergoing PCI. Rationale and design of the Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment for Acute Coronary Syndromes
Topics: Acute Coronary Syndrome; Adult; Aged; Blood Platelets; Clinical Protocols; Clopidogrel; Drug Administration Schedule; Drug Monitoring; Europe; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Research Design; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2017 |
Effects of autologous platelet transfusion on platelet inhibition in ticagrelor-treated and clopidogrel-treated subjects.
Topics: Adenosine; Adult; Blood Component Removal; Blood Platelets; Body Mass Index; Case-Control Studies; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Female; Hemostasis; Humans; Male; Platelet Aggregation Inhibitors; Platelet Transfusion; Purinergic P2Y Receptor Antagonists; Reproducibility of Results; Ticagrelor; Ticlopidine; Time Factors; Young Adult | 2016 |
Efficacy and Safety of Cangrelor in Preventing Periprocedural Complications in Patients With Stable Angina and Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention: The CHAMPION PHOENIX Trial.
Topics: Acute Coronary Syndrome; Adenosine Monophosphate; Aged; Angina, Stable; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Double-Blind Method; Female; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Randomised trial to compare a protective effect of Clopidogrel Versus TIcagrelor on coronary Microvascular injury in ST-segment Elevation myocardial infarction (CV-TIME trial).
Topics: Adenosine; Aged; Clopidogrel; Creatine Kinase; Echocardiography; Female; Humans; Male; Microvessels; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Severity of Illness Index; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine; Vascular Resistance | 2016 |
Pharmacodynamic Assessment of Platelet Reactivity After a Loading Dose of Prasugrel or Clopidogrel in Patients With ST-Segment Elevation Myocardial Infarction.
Topics: Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Prasugrel Hydrochloride; ST Elevation Myocardial Infarction; Ticlopidine | 2016 |
Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack: CHANCE Substudy (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events).
Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Comorbidity; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Ischemic Attack, Transient; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Renal Insufficiency, Chronic; Severity of Illness Index; Stroke; Ticlopidine | 2016 |
A randomised study for optimising crossover from ticagrelor to clopidogrel in patients with acute coronary syndrome. The CAPITAL OPTI-CROSS Study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Cross-Over Studies; Drug Administration Schedule; Drug Substitution; Female; Hemorrhage; Humans; Male; Middle Aged; Ontario; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Effects of clopidogrel therapy on whole blood platelet aggregation, the Plateletworks® assay and coagulation parameters in cats with asymptomatic hypertrophic cardiomyopathy: a pilot study.
Topics: Adenosine Diphosphate; Animals; Asymptomatic Diseases; Blood Coagulation; Cardiomyopathy, Hypertrophic; Cat Diseases; Cats; Clopidogrel; Double-Blind Method; Female; Male; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2017 |
Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation.
Topics: Adult; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Endothelium, Vascular; Female; Genotype; Healthy Volunteers; Humans; Hyperemia; Laser-Doppler Flowmetry; Male; Microcirculation; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Skin; Ticlopidine; Young Adult | 2016 |
Baseline characteristics of the 3096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischemic Stroke' trial.
Topics: Aged; Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Humans; Male; Platelet Aggregation Inhibitors; Severity of Illness Index; Stroke; Ticlopidine; Treatment Outcome | 2017 |
Pharmacokinetics and relative bioavailability of fixed-dose combination of clopidogrel and aspirin versus coadministration of individual formulations in healthy Korean men.
Topics: Acute Coronary Syndrome; Administration, Oral; Adult; Area Under Curve; Aspirin; Biological Availability; Clopidogrel; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Healthy Volunteers; Humans; Male; Middle Aged; Therapeutic Equivalency; Ticlopidine; Young Adult | 2016 |
A comparison of reduced-dose prasugrel and standard-dose clopidogrel in elderly patients with acute coronary syndromes undergoing early percutaneous revascularization: Design and rationale of the randomized Elderly-ACS 2 study.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Cause of Death; Clopidogrel; Drug Therapy, Combination; Early Medical Intervention; Female; Hemorrhage; Humans; Male; Mortality; Myocardial Infarction; Patient Readmission; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Recurrence; Stroke; Ticlopidine; Treatment Outcome | 2016 |
Gender Differences in Associations Between Intraprocedural Thrombotic Events During Percutaneous Coronary Intervention and Adverse Outcomes.
Topics: Aged; Antineoplastic Agents, Phytogenic; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Europe; Female; Follow-Up Studies; Heparin; Hospital Mortality; Humans; Incidence; Intraoperative Complications; Male; Middle Aged; New South Wales; Paclitaxel; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Risk Assessment; Risk Factors; Sex Distribution; Sex Factors; ST Elevation Myocardial Infarction; Survival Rate; Thromboembolism; Ticlopidine; Time Factors; United States | 2016 |
Ticagrelor Compared With Clopidogrel in Patients With Prior Lower Extremity Revascularization for Peripheral Artery Disease.
Topics: Adenosine; Aged; Clopidogrel; Female; Humans; Lower Extremity; Male; Peripheral Arterial Disease; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
Trial design: Rivaroxaban for the prevention of major cardiovascular events after transcatheter aortic valve replacement: Rationale and design of the GALILEO study.
Topics: Aortic Valve Stenosis; Aspirin; Cardiovascular Diseases; Cause of Death; Clopidogrel; Drug Therapy, Combination; Embolism; Factor Xa Inhibitors; Heart Valve Diseases; Humans; Mortality; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Care; Pulmonary Embolism; Rivaroxaban; Stroke; Thrombosis; Ticlopidine; Transcatheter Aortic Valve Replacement; Venous Thrombosis | 2017 |
Effects of various antiplatelet drugs on ex vivo platelet activation induced by equine herpesvirus type 1.
Topics: Animals; Aspirin; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Flow Cytometry; Herpesviridae Infections; Herpesvirus 1, Equid; Horse Diseases; Horses; Male; Pentoxifylline; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Theophylline; Ticlopidine | 2016 |
Platelet reactivity and clinical outcomes in patients using CYP3A4-metabolized statins with clopidogrel in percutaneous coronary intervention.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Logistic Models; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Propensity Score; Prospective Studies; Republic of Korea; Ticlopidine; Treatment Outcome | 2017 |
Safety of 6-month duration of dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndromes: Rationale and design of the Smart Angioplasty Research Team-safety of 6-month duration of Dual Antiplatelet Therapy
Topics: Acute Coronary Syndrome; Adult; Aspirin; Clopidogrel; Drug Monitoring; Drug-Eluting Stents; Everolimus; Female; Hemorrhage; Humans; Immunosuppressive Agents; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Republic of Korea; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Histamine-2 Receptor Antagonist Cannot Prevent Recurrent Peptic Ulcers in Patients With Atherosclerotic Diseases Who Receive Platelet ADP Receptor Antagonist Monotherapy: A Randomized-Controlled, Double-Blind, and Double-Dummy Trial.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atherosclerosis; Clopidogrel; Double-Blind Method; Famotidine; Female; Helicobacter Infections; Histamine H2 Antagonists; Humans; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer Hemorrhage; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Recurrence; Ticlopidine; Treatment Outcome | 2017 |
Comparative pharmacodynamic effects of two clopidogrel formulations under steady-state conditions in healthy Thai volunteers
.
Topics: Adult; Area Under Curve; Asian People; Blood Platelets; Clopidogrel; Cross-Over Studies; Drug Compounding; Drugs, Generic; Healthy Volunteers; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thailand; Therapeutic Equivalency; Ticlopidine; Young Adult | 2017 |
Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease.
Topics: Adenosine; Aged; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Female; Hemorrhage; Humans; Intermittent Claudication; Ischemia; Kaplan-Meier Estimate; Leg; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2017 |
Genetic Polymorphism of CYP2C19 and Inhibitory Effects of Ticagrelor and Clopidogrel Towards Post-Percutaneous Coronary Intervention (PCI) Platelet Aggregation in Patients with Acute Coronary Syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Ticagrelor Versus Clopidogrel in Comatose Survivors of Out-of-Hospital Cardiac Arrest Undergoing Percutaneous Coronary Intervention and Hypothermia: A Randomized Study.
Topics: Activation, Metabolic; Adenosine; Clopidogrel; Coma; Humans; Hypothermia, Induced; Out-of-Hospital Cardiac Arrest; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Resuscitation; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
New single-nucleotide polymorphisms associated with differences in platelet reactivity and their influence on survival in patients with type 2 diabetes treated with acetylsalicylic acid: an observational study.
Topics: Aged; Alleles; Aspirin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 2; Female; Genotype; Humans; Inflammation; Male; Middle Aged; Platelet Activation; Polymorphism, Single Nucleotide; Receptors, Thromboxane A2, Prostaglandin H2; Survival Analysis; Ticlopidine | 2017 |
Ischaemic and bleeding outcomes in elderly patients undergoing a prolonged versus shortened duration of dual antiplatelet therapy after percutaneous coronary intervention: insights from the PRODIGY randomised trial.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine | 2017 |
The effectiveness and safety of dual antiplatelet therapy in ischemic cerebrovascular disease with intracranial and extracranial arteriostenosis in Chinese patients: A randomized and controlled trail.
Topics: Arterial Occlusive Diseases; Aspirin; China; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hemorrhage; Humans; Intracranial Arterial Diseases; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome | 2017 |
Randomized Comparison of Oral P2Y
Topics: Adenosine; Adenosine Monophosphate; Administration, Oral; Aged; Blood Platelets; Clopidogrel; Coronary Disease; Drug Substitution; Female; Germany; Humans; Infusions, Intravenous; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Optimal Same-Day Platelet Inhibition in Patients Receiving Drug-Eluting Stents With or Without Previous Maintenance Thienopyridine Therapy: from the Evaluation of Platelet Inhibition in Patients Having A VerifyNow Assay (EPIPHANY) Trial.
Topics: Clopidogrel; Coronary Disease; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Pyridines; Risk Factors; Ticlopidine; Treatment Outcome | 2017 |
Effect of Shexiang baoxin pills on clopidogrel resistance in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Biomarkers; China; Clopidogrel; Drug Resistance; Drugs, Chinese Herbal; Female; Heart Rate; Humans; Male; Matrix Metalloproteinase 2; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Tablets; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Association of multiple infarctions and ICAS with outcomes of minor stroke and TIA.
Topics: Aged; Aspirin; Brain; Brain Infarction; Brain Ischemia; Clopidogrel; Female; Humans; Image Processing, Computer-Assisted; Intracranial Arteriosclerosis; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2017 |
Genotyping-guided approach versus the conventional approach in selection of oral P2Y12 receptor blockers in Chinese patients suffering from acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Alleles; Asian People; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Expression; Gene Frequency; Genotype; Genotyping Techniques; Humans; Male; Middle Aged; Mutation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor; Ticlopidine | 2017 |
Myocardial Infarction Risk After Discontinuation of Thienopyridine Therapy in the Randomized DAPT Study (Dual Antiplatelet Therapy).
Topics: Acute Coronary Syndrome; Aged; Angina, Stable; Aspirin; Clopidogrel; Coronary Thrombosis; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Incidence; Intention to Treat Analysis; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Randomized Angiographic and Intravascular Ultrasound Comparison of Dual-Antiplatelet Therapy vs Triple-Antiplatelet Therapy to Reduce Neointimal Tissue Proliferation in Diabetic Patients.
Topics: Aspirin; Cilostazol; Clopidogrel; Comorbidity; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Diabetes Mellitus; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Neointima; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Sirolimus; Tetrazoles; Ticlopidine; Treatment Outcome | 2017 |
Optimal aNtiplatelet pharmacotherapy guided by bedSIDE genetic or functional TESTing in elective PCI patients: A pilot study: ONSIDE TEST pilot.
Topics: Adolescent; Adult; Aged; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pilot Projects; Platelet Aggregation; Platelet Function Tests; Point-of-Care Systems; Prasugrel Hydrochloride; Preoperative Care; Retrospective Studies; Ticlopidine; Young Adult | 2017 |
Impact of Glycemic Control on Efficacy of Clopidogrel in Transient Ischemic Attack or Minor Stroke Patients With
Topics: Aged; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Double-Blind Method; Female; Glycated Serum Albumin; Glycation End Products, Advanced; Heterozygote; Humans; Ischemic Attack, Transient; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Recurrence; Risk; Serum Albumin; Stroke; Ticlopidine | 2017 |
Efficacy of cilostazol-based dual antiplatelet treatment in patients undergoing carotid artery stenting.
Topics: Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Stroke; Tetrazoles; Ticlopidine | 2017 |
Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): a double-blind, multicentre, randomised trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Clopidogrel; Coronary Angiography; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Factor Xa Inhibitors; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rivaroxaban; Thrombolytic Therapy; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
Biological effects of ticagrelor over clopidogrel in patients with stable coronary artery disease and chronic obstructive pulmonary disease.
Topics: Adenosine; Aged; Anticoagulants; Apoptosis; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytokines; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Nitric Oxide; Percutaneous Coronary Intervention; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; Ticagrelor; Ticlopidine | 2017 |
The pharmacodynamics of low and standard doses of ticagrelor in patients with end stage renal disease on hemodialysis.
Topics: Adenosine; Adult; Aged; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Renal Dialysis; Ticagrelor; Ticlopidine | 2017 |
Effect of ticagrelor with clopidogrel on high on-treatment platelet reactivity in acute stroke or transient ischemic attack (PRINCE) trial: Rationale and design.
Topics: Adenosine; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Heterozygote; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Research Design; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
Predicting the risk of bleeding during dual antiplatelet therapy after acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Bypass; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Global Health; Hemorrhage; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Ticlopidine; Time Factors | 2017 |
Characteristics of dyspnoea and associated clinical outcomes in the CHAMPION PHOENIX study.
Topics: Adenosine Monophosphate; Aged; Clopidogrel; Coronary Occlusion; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Dyspnea; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Percutaneous Coronary Intervention; Receptors, Purinergic P2Y12; Survival Analysis; Ticlopidine; Treatment Outcome; Withholding Treatment | 2017 |
Impact of dual antiplatelet therapy after coronary artery bypass surgery on 1-year outcomes in the Arterial Revascularization Trial.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Europe; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Propensity Score; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Coronary Syndrome; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ranitidine; Republic of Korea; Single-Blind Method; Ticlopidine | 2017 |
Relationship Between Peak Troponin Values and Long-Term Ischemic Events Among Medically Managed Patients With Acute Coronary Syndromes.
Topics: Acute Coronary Syndrome; Aged; Biomarkers; Chi-Square Distribution; Clopidogrel; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Linear Models; Male; Middle Aged; Multivariate Analysis; Non-ST Elevated Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Troponin; Up-Regulation | 2017 |
Growth Differentiation Factor 15 at 1 Month After an Acute Coronary Syndrome Is Associated With Increased Risk of Major Bleeding.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Biomarkers; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Growth Differentiation Factor 15; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Predictive Value of Tests; Proportional Hazards Models; Risk Assessment; Risk Factors; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Up-Regulation | 2017 |
Risks and benefits of clopidogrel-aspirin in minor stroke or TIA: Time course analysis of CHANCE.
Topics: Aspirin; Brain Ischemia; China; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Risk; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Extended Duration Dual Antiplatelet Therapy After Coronary Stenting Among Patients With Peripheral Arterial Disease: A Subanalysis of the Dual Antiplatelet Therapy Study.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Risk Factors; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Benefit of switching dual antiplatelet therapy after acute coronary syndrome: the TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Combinations; Drug Substitution; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Medication Adherence; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Tablets; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
PRotective Effect on the coronary microcirculation of patients with DIabetes by Clopidogrel or Ticagrelor (PREDICT): study rationale and design. A randomized multicenter clinical trial using intracoronary multimodal physiology.
Topics: Adenosine; Blood Platelets; Clinical Protocols; Clopidogrel; Coronary Artery Disease; Coronary Circulation; Diabetes Mellitus, Type 2; Humans; Microcirculation; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Research Design; Risk Factors; Spain; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Vasodilation | 2017 |
Aspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve: The ARTE (Aspirin Versus Aspirin + Clopidogrel Following Transcatheter Aortic Valve Implantation) Randomi
Topics: Aged; Aged, 80 and over; Aortic Valve; Aspirin; Balloon Valvuloplasty; Canada; Clopidogrel; Drug Therapy, Combination; Early Termination of Clinical Trials; Europe; Female; Fibrinolytic Agents; Heart Valve Prosthesis; Hemorrhage; Humans; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Factors; South America; Stroke; Thrombosis; Ticlopidine; Time Factors; Transcatheter Aortic Valve Replacement; Treatment Outcome | 2017 |
[IMPACT OF ATORVASTATIN AND ROSUVASTATIN ON RESIDUAL ON-CLOPIDOGREL TREATMENT PLATELET REACTIVITY IN PATIENTS WITH ISCHEMIC HEART DISEASE AND TYPE 2 DIABETES MELLITUS AFTER ACUTE CORONARY SYNDROME].
Topics: Acute Coronary Syndrome; Aspirin; Atorvastatin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 2; Drug Interactions; Drug Substitution; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Rosuvastatin Calcium; Ticlopidine | 2017 |
Cangrelor reduces the risk of ischemic complications in patients with single-vessel and multi-vessel disease undergoing percutaneous coronary intervention: Insights from the CHAMPION PHOENIX trial.
Topics: Adenosine Monophosphate; Administration, Oral; Aged; Cause of Death; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Global Health; Humans; Incidence; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Postoperative Complications; Purinergic P2Y Receptor Antagonists; Survival Rate; Ticlopidine; Time Factors | 2017 |
Dual antiplatelet therapy in patients with diabetes and acute coronary syndromes managed without revascularization.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Diabetes Mellitus; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
The Effect of Clopidogrel on the Response to Ischemia Reperfusion.
Topics: Adolescent; Adult; Biomarkers; Chemokine CCL5; Clopidogrel; Endothelium, Vascular; Female; Healthy Volunteers; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Platelet Aggregation Inhibitors; Radial Artery; Regional Blood Flow; Reperfusion Injury; Ticlopidine; Time Factors; Ultrasonography, Doppler; Upper Extremity; Vasodilation; Young Adult | 2017 |
Variability of platelet response to clopidogrel is not related to adverse cardiovascular events in patients with stable coronary artery disease undergoing percutaneous coronary intervention.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Genotype; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Stents; Ticlopidine | 2017 |
Relative efficacy and safety of ticagelor vs clopidogrel as a function of time to invasive management in non-ST-segment elevation acute coronary syndrome in the PLATO trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Revascularization; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Report: Impact of drug combination of clopidogrel and pantoprazole In the prognosis of patients with transient ischemic attack.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Chi-Square Distribution; China; Clopidogrel; Cytochrome P-450 CYP2C19; Disease Progression; Drug Therapy, Combination; Female; Genotype; Humans; Incidence; Ischemic Attack, Transient; Logistic Models; Male; Middle Aged; Multivariate Analysis; Pantoprazole; Pharmacogenomic Variants; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Use of the Dual-Antiplatelet Therapy Score to Guide Treatment Duration After Percutaneous Coronary Intervention.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2017 |
Platelet-related biomarkers and their response to inhibition with aspirin and p2y
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Biomarkers; Blood Platelets; CD40 Ligand; Clopidogrel; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Time Factors | 2017 |
Short-term efficacy and safety of three different antiplatelet regimens in diabetic patients treated with primary percutaneous coronary intervention: a randomised study.
Topics: Adenosine; Aged; Aspirin; Clopidogrel; Diabetic Cardiomyopathies; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Patient Safety; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2017 |
Morphological and pharmacological determinants of peri-procedural myocardial infarction following elective stent implantation: Optical coherence tomography sub-analysis of the PRASFIT-Elective study.
Topics: Aged; Aspirin; Clopidogrel; Creatine Kinase, MB Form; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2017 |
Dual Antiplatelet Therapy for 6 Versus 18 Months After Biodegradable Polymer Drug-Eluting Stent Implantation.
Topics: Absorbable Implants; Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Intention to Treat Analysis; Japan; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymers; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
6- Versus 24-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents in Patients Nonresistant to Aspirin: Final Results of the ITALIC Trial (Is There a Life for DES After Discontinuation of Clopidogrel).
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; France; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Rationale and Design for a Randomized Comparison of Efficacy and Safety between Aspirin and Clopidogrel in Atrial Fibrillation Patients with Low Stroke Risk: CESAC-AF trial.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Endoscopy, Digestive System; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Research Design; Risk Factors; Stroke; Ticlopidine | 2017 |
Microbleeds in the Secondary Prevention of Small Subcortical Strokes Trial: Stroke, mortality, and treatment interactions.
Topics: Aspirin; Cerebral Hemorrhage; Clopidogrel; Double-Blind Method; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Secondary Prevention; Stroke, Lacunar; Ticlopidine | 2017 |
Time course of the antiplatelet effect after switching to clopidogrel from initial prasugrel therapy in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Drug Substitution; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.
Topics: Adenosine; Administration, Intravenous; Adolescent; Adult; Aspirin; Cells, Cultured; Clopidogrel; Cytokines; Drug Therapy, Combination; Endotoxemia; Endotoxins; Healthy Volunteers; Humans; Inflammation; Inflammation Mediators; Male; Netherlands; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2017 |
Prasugrel as opposed to clopidogrel improves endothelial nitric oxide bioavailability and reduces platelet-leukocyte interaction in patients with unstable angina pectoris: A randomized controlled trial.
Topics: Aged; Angina, Unstable; Biological Availability; Blood Platelets; Clopidogrel; Double-Blind Method; Endothelium, Vascular; Female; Humans; Leukocytes; Male; Middle Aged; Nitric Oxide; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2017 |
Ticagrelor mitigates ischaemia-reperfusion induced vascular endothelial dysfunction in healthy young males - a randomized, single-blinded study.
Topics: Adenosine; Administration, Oral; Adolescent; Adult; Austria; Blood Flow Velocity; Clopidogrel; Drug Administration Schedule; Endothelium, Vascular; Forearm; Healthy Volunteers; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Regional Blood Flow; Reperfusion Injury; Single-Blind Method; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Vasodilation; Vasodilator Agents; Young Adult | 2017 |
Validation of the DAPT score in patients randomized to 6 or 12 months clopidogrel after predominantly second-generation drug-eluting stents.
Topics: Aged; Aspirin; Clinical Decision-Making; Clopidogrel; Coronary Disease; Coronary Thrombosis; Decision Support Techniques; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Predictive Value of Tests; Proportional Hazards Models; Prosthesis Design; Reproducibility of Results; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Cangrelor Versus Clopidogrel on a Background of Unfractionated Heparin (from CHAMPION PHOENIX).
Topics: Adenosine Monophosphate; Aged; Anticoagulants; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Heparin; Humans; Intraoperative Period; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Ticlopidine; Treatment Outcome | 2017 |
Prasugrel vs. clopidogrel in contemporary Western European patients with acute coronary syndromes receiving drug-eluting stents: Comparative cost-effectiveness analysis from the BASKET-PROVE cohorts.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Cohort Studies; Cost-Benefit Analysis; Drug-Eluting Stents; Europe; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Retrospective Studies; Ticlopidine | 2017 |
Antithrombotic potency of ticagrelor versus clopidogrel in type-2 diabetic patients with cardiovascular disease.
Topics: Adenosine; Aged; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Coronary Thrombosis; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation.
Topics: Adenosine; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Dabigatran; Drug Therapy, Combination; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk; Ticagrelor; Ticlopidine; Warfarin | 2017 |
Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Administration Schedule; Drug Monitoring; Europe; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Stroke; Ticlopidine | 2017 |
Discordance Between VASP Phosphorylation and Platelet Aggregation in Defining High On-Clopidogrel Platelet Reactivity After ST-Segment Elevation Myocardial Infarction.
Topics: Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Smoking; ST Elevation Myocardial Infarction; Ticlopidine; Time Factors | 2018 |
PIK3CG single nucleotide polymorphisms are associated with poor responsiveness to clopidogrel and increased risk of ischemia in patients with coronary heart disease.
Topics: Aged; Class Ib Phosphatidylinositol 3-Kinase; Clopidogrel; Coronary Disease; Drug Resistance; Female; Gene Frequency; Haplotypes; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Ticlopidine | 2017 |
Pharmacodynamics and pharmacokinetics of ticagrelor vs. clopidogrel in patients with acute coronary syndromes and chronic kidney disease.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Creatinine; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Renal Elimination; Renal Insufficiency, Chronic; Ticagrelor; Ticlopidine; Treatment Outcome | 2018 |
SAFE (Sarpogrelate Anplone in Femoro-popliteal artery intervention Efficacy) study: study protocol for a randomized controlled trial.
Topics: Amputation, Surgical; Aspirin; Clinical Protocols; Clopidogrel; Computed Tomography Angiography; Constriction, Pathologic; Drug Therapy, Combination; Endovascular Procedures; Femoral Artery; Hemorrhage; Humans; Limb Salvage; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Popliteal Artery; Prospective Studies; Recurrence; Republic of Korea; Research Design; Risk Factors; Succinates; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2017 |
Effects of ticagrelor versus clopidogrel on platelet function in fibrinolytic-treated STEMI patients undergoing early PCI.
Topics: Adenosine; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Preoperative Care; Prognosis; Prospective Studies; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Thrombolytic Therapy; Ticagrelor; Ticlopidine; Time Factors | 2017 |
Characterization of the Average Daily Ischemic and Bleeding Risk After Primary PCI for STEMI.
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Assessment; ST Elevation Myocardial Infarction; Stents; Ticlopidine; Time Factors; United States | 2017 |
Cangrelor compared with clopidogrel in patients with prior myocardial infarction - Insights from the CHAMPION trials.
Topics: Adenosine Monophosphate; Aged; Clopidogrel; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2018 |
Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment.
Topics: Adult; Aged; Aspirin; Blood Platelets; Catechin; Clopidogrel; Coronary Stenosis; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Republic of Korea; Ticagrelor; Ticlopidine | 2018 |
Stress Hyperglycemia and Prognosis of Minor Ischemic Stroke and Transient Ischemic Attack: The CHANCE Study (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events).
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Blood Glucose; Brain Ischemia; Clopidogrel; Double-Blind Method; Female; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Hyperglycemia; Male; Middle Aged; Risk Factors; Serum Albumin; Stroke; Ticlopidine | 2017 |
Bioequivalence and pharmacokinetic/pharmacodynamic correlation of clopidogrel in healthy Thai subjects
.
Topics: Adolescent; Adult; Clopidogrel; Cross-Over Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Therapeutic Equivalency; Ticlopidine; Young Adult | 2017 |
Double-Dose Versus Standard-Dose Clopidogrel According to Smoking Status Among Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention.
Topics: Acute Coronary Syndrome; Aged; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Recurrence; Risk Factors; Smoking; ST Elevation Myocardial Infarction; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Long-term pharmacodynamic effects of Ticagrelor versus Clopidogrel in fibrinolytic-treated STEMI patients undergoing early PCI.
Topics: Adenosine; Aged; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; ST Elevation Myocardial Infarction; Thrombolytic Therapy; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2018 |
Clopidogrel Therapy in Patients with Cardiovascular Disease Undergoing Transurethral Resection of the Prostate: A Step Towards Individualization.
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Humans; Male; P-Selectin; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Prostatic Hyperplasia; Ticlopidine; Transurethral Resection of Prostate | 2017 |
Comparison of Multiplate, Platelet Function Analyzer-200, and Plateletworks in Healthy Dogs Treated with Aspirin and Clopidogrel.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Dogs; Double-Blind Method; Drug Therapy, Combination; Female; Male; Platelet Aggregation; Platelet Count; Platelet Function Tests; Ticlopidine | 2018 |
Effects of four antiplatelet/statin combined strategies on immune and inflammatory responses in patients with acute myocardial infarction undergoing pharmacoinvasive strategy: Design and rationale of the B and T Types of Lymphocytes Evaluation in Acute My
Topics: Adenosine; Anti-Inflammatory Agents; B-Lymphocytes; Biomarkers; Brazil; Clinical Protocols; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Enzyme-Linked Immunospot Assay; Ezetimibe; Female; Flow Cytometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Magnetic Resonance Imaging; Male; Metabolomics; Platelet Aggregation Inhibitors; Proteomics; Research Design; Rosuvastatin Calcium; Simvastatin; ST Elevation Myocardial Infarction; Stroke Volume; T-Lymphocytes; Thrombolytic Therapy; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling | 2017 |
Outcomes of Patients with Critical Limb Ischaemia in the EUCLID Trial.
Topics: Adenosine; Aged; Clopidogrel; Female; Hospitalization; Humans; Hypertension; Incidence; Ischemia; Kaplan-Meier Estimate; Limb Salvage; Lower Extremity; Male; Middle Aged; Peripheral Arterial Disease; Proportional Hazards Models; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome; Vascular Surgical Procedures | 2018 |
Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.
Topics: Acute Disease; Aged; Aspirin; Brain Ischemia; Clopidogrel; Denmark; Dipyridamole; Drug Therapy, Combination; Female; Georgia; Hemorrhage; Humans; Ischemia; Ischemic Attack, Transient; Male; Middle Aged; New Zealand; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Research Design; Risk Assessment; Stroke; Thrombolytic Therapy; Ticlopidine; Treatment Outcome; United Kingdom | 2018 |
Switching from clopidogrel to prasugrel to protect early invasive treatment in acute coronary syndromes: Results of the switch over trial.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug Substitution; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Ticlopidine | 2018 |
Risk of discontinuation of clopidogrel after 1 month following bare-metal stents: a propensity-score adjusted comparison with continued administration of clopidogrel after drug-eluting stents.
Topics: Aged; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Mortality; Myocardial Infarction; Platelet Aggregation Inhibitors; Propensity Score; Stents; Ticlopidine; Time Factors | 2018 |
Effects of genetic variants on platelet reactivity and one-year clinical outcomes after percutaneous coronary intervention: A prospective multicentre registry study.
Topics: Aged; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Postoperative Complications; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2018 |
Effect of cilostazol on platelet reactivity among patients with peripheral artery disease on clopidogrel therapy.
Topics: Aged; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; Blood Platelets; Cilostazol; Clopidogrel; Cross-Sectional Studies; Cytochrome P-450 CYP2C19; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Peripheral Arterial Disease; Pilot Projects; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Purinergic P2Y12; Tetrazoles; Ticlopidine | 2018 |
Tiny Cerebral Aneurysms Can Be Treated Safely and Effectively with Low-Profile Visualized Intraluminal Support Stent-Assisted Coiling or Coiling Alone.
Topics: Adult; Aged; Aneurysm, Ruptured; Aspirin; Clopidogrel; Embolization, Therapeutic; Endovascular Procedures; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Stents; Thrombosis; Ticlopidine | 2018 |
Another Endovascular Therapy Strategy for Acute Tandem Occlusion: Protect-Expand-Aspiration-Revascularization-Stent (PEARS) Technique.
Topics: Acute Disease; Aged; Aspirin; Carotid Artery Thrombosis; Carotid Artery, Internal; Cerebral Revascularization; Clopidogrel; Endovascular Procedures; Feasibility Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Severity of Illness Index; Stents; Thrombectomy; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2018 |
A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial - PRASTRO-I trial.
Topics: Clopidogrel; Double-Blind Method; Humans; Japan; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stroke; Ticlopidine; Treatment Outcome | 2018 |
A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Study of the Effects of Tongxinluo Capsules in Acute Coronary Syndrome Patients with High On-Treatment Platelet Reactivity.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Platelets; Capsules; Clopidogrel; Double-Blind Method; Drugs, Chinese Herbal; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2018 |
6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (SMART-DATE): a randomised, open-label, non-inferiority trial.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Republic of Korea; Ticlopidine; Treatment Outcome | 2018 |
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA.
Topics: Aged; Aspirin; Brain Ischemia; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Ischemia; Ischemic Attack, Transient; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Secondary Prevention; Stroke; Ticlopidine | 2018 |
Randomized Comparison of Strut Coverage between Ticagrelor and Clopidogrel in Acute Myocardial Infarction at 3-Month Optical Coherence Tomography.
Topics: Adenosine; Aged; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Neointima; Prospective Studies; Prostheses and Implants; Ticagrelor; Ticlopidine; Tomography, Optical Coherence; Treatment Outcome | 2018 |
Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort.
Topics: Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Bisoprolol; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Clopidogrel; Cohort Studies; Female; Humans; Male; Mass Spectrometry; Platelet Aggregation Inhibitors; Prospective Studies; Reproducibility of Results; Tandem Mass Spectrometry; Ticlopidine | 2018 |
Influence of cytochrome P450 polymorphisms on the antiplatelet effects of prasugrel in patients with non-cardioembolic stroke previously treated with clopidogrel.
Topics: Aged; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Double-Blind Method; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Practice Guidelines as Topic; Prasugrel Hydrochloride; Stroke; Ticlopidine | 2018 |
Aspirin plus clopidogrel may reduce the risk of early neurologic deterioration in ischemic stroke patients carrying CYP2C19*2 reduced-function alleles.
Topics: Aged; Aspirin; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Heterozygote; Humans; Incidence; Male; Neurodegenerative Diseases; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Stroke; Ticlopidine | 2018 |
Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-la
Topics: Adenosine; Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2018 |
Beneficial effects of combined administration of Clopidogrel and Aspirin on the levels of proinflammatory cytokines, cardiac function, and prognosis in ST-segment elevation myocardial infarction: A comparative study.
Topics: Aged; Aspirin; Clopidogrel; Cytokines; Drug Therapy, Combination; Female; Heart; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; ST Elevation Myocardial Infarction; Ticlopidine; Treatment Outcome | 2018 |
Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Acetylsalicylic Acid in Fixed-Dose Combination with Clopidogrel Versus Enteric Aspirin in Chinese Subjects Under Fasting Conditions: A Phase 1, Open-Label, Randomized
Topics: Acute Coronary Syndrome; Adult; Area Under Curve; Asian People; Aspirin; Clopidogrel; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Male; Therapeutic Equivalency; Thrombosis; Ticlopidine | 2020 |
Blunting periprocedural myocardial necrosis: Rationale and design of the randomized ALPHEUS study.
Topics: Aged; Clopidogrel; Coronary Angiography; Coronary Disease; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2020 |
Prospective partially randomized comparison of clopidogrel loading versus maintenance dosing to prevent periprocedural myocardial infarction after stenting for stable angina pectoris: Results from the "Method of Clopidogrel Pre-treatment Undergoing Conven
Topics: Angina, Stable; Clopidogrel; Coronary Angiography; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Treatment Outcome | 2020 |
Impact of one-month DAPT followed by aspirin monotherapy in patients undergoing percutaneous coronary intervention according to clinical presentation: a post hoc analysis of the randomised One-Month DAPT trial.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2022 |
Time of Resumption of Antiplatelet Drugs After Upper Gastrointestinal Hemorrhage.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2022 |
Effect of cocoa (
Topics: Aspirin; Cacao; Chocolate; Clopidogrel; Coronary Artery Disease; Humans; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2022 |
Ticagrelor inhibits platelet aggregation and reduces inflammatory burden more than clopidogrel in patients with stages 4 or 5 chronic kidney disease.
Topics: Adenosine; Clopidogrel; Female; Humans; Inflammation; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Renal Insufficiency, Chronic; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2023 |
Randomized, Double-Blind, Active Comparator Pharmacodynamic Study of Platelet Inhibition with Crushed and Integral Formulations of Clopidogrel and Ticagrelor in Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2023 |
Aspirin Dosing for Secondary Prevention of Atherosclerotic Cardiovascular Disease in Patients Treated With P2Y12 Inhibitors.
Topics: Acute Coronary Syndrome; Aspirin; Atherosclerosis; Cardiovascular Diseases; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Secondary Prevention; Ticlopidine | 2023 |
4962 other study(ies) available for ticlopidine and clopidogrel
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites.
Topics: Clopidogrel; Drug Design; Inhibitory Concentration 50; Methicillin-Resistant Staphylococcus aureus; Molecular Structure; Oxidation-Reduction; Teichoic Acids; Ticlopidine | 2014 |
Importance of platelets in experimental venous thrombosis in the rat.
Topics: Animals; Blood Platelets; Clopidogrel; Disease Models, Animal; Heparin; Hirudins; Leukopenia; Male; Mechlorethamine; Partial Thromboplastin Time; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Thrombocytopenia; Thrombophlebitis; Thromboplastin; Ticlopidine | 1992 |
Comparative arterial antithrombotic activity of clopidogrel and acetyl salicylic acid in the pig.
Topics: Animals; Aspirin; Bleeding Time; Clopidogrel; Disease Models, Animal; Female; Femoral Artery; Fibrinolytic Agents; Male; Platelet Aggregation; Swine; Thrombosis; Ticlopidine | 1992 |
Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel.
Topics: Adenosine Diphosphate; Animals; Choledochostomy; Clopidogrel; Dose-Response Relationship, Drug; Female; Hepatectomy; Intestinal Mucosa; Liver; Perfusion; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Ticlopidine | 1992 |
ADP receptor induced activation of guanine nucleotide binding proteins in rat platelet membranes--an effect selectively blocked by the thienopyridine clopidogrel.
Topics: Adenylyl Cyclases; Animals; Blood Platelets; Cell Membrane; Clopidogrel; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Platelet Aggregation Inhibitors; Purinergic Antagonists; Rats; Rats, Inbred Strains; Sulfur Radioisotopes; Ticlopidine | 1992 |
[Antiplatelet effect of clopidogrel].
Topics: Adenosine Diphosphate; Adolescent; Adult; Animals; Bleeding Time; Clopidogrel; Disease Models, Animal; Dogs; Drug Evaluation; Female; Humans; Intracranial Embolism and Thrombosis; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Rabbits; Rats; Thrombosis; Ticlopidine | 1992 |
ADP plays an important role in mediating platelet aggregation and cyclic flow variations in vivo in stenosed and endothelium-injured canine coronary arteries.
Topics: Adenosine Diphosphate; Animals; Apyrase; Bridged Bicyclo Compounds, Heterocyclic; Clopidogrel; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Thromboxane A2; Ticlopidine | 1992 |
[Arterioarterial shunt coated with collagen. A model of acute arterial thrombosis for testing antithrombotic agents in rats].
Topics: Animals; Aspirin; Carotid Arteries; Clopidogrel; Collagen; Disease Models, Animal; Fistula; Graft Occlusion, Vascular; Male; Models, Biological; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thrombolytic Therapy; Thrombosis; Ticlopidine | 1991 |
Ticlopidine and clopidogrel (SR 25990C) selectively neutralize ADP inhibition of PGE1-activated platelet adenylate cyclase in rats and rabbits.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Clopidogrel; Enzyme Activation; Female; In Vitro Techniques; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Stereoisomerism; Ticlopidine | 1991 |
The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibrinogen binding without modifying the membrane glycoprotein IIb-IIIa complex in rat and in man.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Female; Fibrinogen; Humans; Immunoelectrophoresis, Two-Dimensional; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Precipitin Tests; Rats; Rats, Inbred Strains; Ticlopidine | 1990 |
Broad spectrum anti-platelet activity of ticlopidine and PCR 4099 involves the suppression of the effects of released ADP.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcimycin; Clopidogrel; Diglycerides; Female; Platelet Aggregation Inhibitors; Rats; Serotonin; Tetradecanoylphorbol Acetate; Thrombin; Ticlopidine; Type C Phospholipases | 1987 |
ADP plays a key role in thrombogenesis in rats.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; In Vitro Techniques; Ketanserin; Platelet Aggregation; Rats; Rats, Inbred Strains; Serotonin; Thrombosis; Ticlopidine | 1988 |
The role of platelets and ADP in experimental thrombosis induced by venous stasis in the rat.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Blood Transfusion; Clopidogrel; Male; Platelet Count; Platelet Transfusion; Rats; Thrombocytopenia; Thrombophlebitis; Ticlopidine | 1988 |
Effect of PCR 4099 on ADP-induced calcium movements and phosphatidic acid production in rat platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Clopidogrel; Fibrinogen; In Vitro Techniques; Phosphatidic Acids; Platelet Aggregation; Rats; Ticlopidine; Type C Phospholipases | 1988 |
Inhibition of the thrombocytopenic effect of exogenous and endogenous thrombin by PCR 4099 (d,1)methyl 2-(2-chlorophenyl)-2(4,5,6, 7-tetrahydrothieno (3,2-c)pyridin-5-yl) acetate.hydrochloride.monohydrate.
Topics: Animals; Carrageenan; Clopidogrel; Ellagic Acid; Female; Hypotension; Male; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Thrombin; Thrombocytopenia; Ticlopidine | 1987 |
Aprotinin reduces clopidogrel-induced prolongation of the bleeding time in the rat.
Topics: Animals; Aprotinin; Arteriovenous Shunt, Surgical; Bleeding Time; Clopidogrel; Constriction; Hemorrhagic Disorders; Hemostasis; Rats; Rats, Sprague-Dawley; Thromboplastin; Thrombosis; Ticlopidine | 1993 |
SR 25989 inhibits healing of a mechanical wound of confluent human saphenous vein endothelial cells which is modulated by standard heparin and growth factors.
Topics: Cell Division; Cells, Cultured; Clopidogrel; Culture Media; Endothelium, Vascular; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Heparin; Humans; Neovascularization, Pathologic; Platelet Aggregation Inhibitors; Ticlopidine; Wound Healing | 1994 |
Inhibitory effect of clopidogrel, vapiprost and argatroban on the middle cerebral artery thrombosis in the rat.
Topics: Animals; Arginine; Biphenyl Compounds; Cerebral Arteries; Cerebrovascular Circulation; Clopidogrel; Fibrinolytic Agents; Heptanoic Acids; Intracranial Embolism and Thrombosis; Male; Photic Stimulation; Pipecolic Acids; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Receptors, Thromboxane; Regional Blood Flow; Sulfonamides; Thromboxane A2; Ticlopidine | 1995 |
Axial dependence of collagen-induced thrombus formation in flowing non-anticoagulated human blood. Anti-platelet drugs impair thrombus growth and increase platelet-collagen adhesion.
Topics: Aspirin; Blood Coagulation; Clopidogrel; Collagen; Fibrin; Hemorheology; Humans; Male; Perfusion; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Smoking; Stress, Mechanical; Surface Properties; Ticlopidine | 1995 |
An experimental myocardial infarction model in the rat and its properties.
Topics: Animals; Biphenyl Compounds; Clopidogrel; Coronary Vessels; Disease Models, Animal; Electrocardiography; Heptanoic Acids; Ketanserin; Male; Myocardial Infarction; Oxygen; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombosis; Ticlopidine | 1995 |
[An experimental study of arterial graft implantation--the effects of an anti-thrombin agent, argatroban, and an anti-platelet agent, clopidogrel (SR 25990 C) on the inner capsule].
Topics: Angioscopy; Animals; Antithrombins; Aorta, Abdominal; Arginine; Blood Coagulation; Blood Vessel Prosthesis; Clopidogrel; Dogs; Fibrinolysis; Graft Occlusion, Vascular; Pipecolic Acids; Platelet Aggregation Inhibitors; Sulfonamides; Ticlopidine | 1994 |
The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A.
Topics: Adenosine Diphosphate; Animals; Biotransformation; Chromatography, High Pressure Liquid; Clopidogrel; Cytochrome P-450 Enzyme System; Female; Isoenzymes; Microsomes, Liver; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ticlopidine | 1994 |
Evidence for the existence of two different ADP-binding sites on rat platelets.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Binding Sites; Blood Platelets; Clopidogrel; Female; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Signal Transduction; Ticlopidine | 1994 |
Clopidogrel is more effective than aspirin in preventing coronary artery reocclusion after thrombolysis.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Therapy, Combination; Hematocrit; Heparin; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator | 1993 |
Clopidogrel is more effective than aspirin as adjuvant treatment to prevent reocclusion after thrombolysis.
Topics: Animals; Aspirin; Clopidogrel; Coronary Thrombosis; Dogs; Drug Therapy, Combination; Fibrinolytic Agents; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 1994 |
Effect of various drugs on adriamycin-enhanced venous thrombosis in the rat: importance of PAF.
Topics: Animals; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Doxorubicin; Leukocyte Count; Male; Platelet Activating Factor; Platelet Count; Rats; Rats, Sprague-Dawley; Thiazoles; Thrombophlebitis; Ticlopidine | 1994 |
Effect of various antiplatelet agents on acute arterial thrombosis in the rat.
Topics: Acute Disease; Amino Acid Sequence; Animals; Aspirin; Carotid Artery Thrombosis; Clopidogrel; Electric Stimulation; Hirudin Therapy; Male; Molecular Sequence Data; Oligopeptides; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thiazoles; Thrombolytic Therapy; Thromboxane-A Synthase; Ticlopidine | 1993 |
Effect of aspirin and clopidogrel on platelet-dependent tissue factor expression in endothelial cells.
Topics: Adenosine Diphosphate; Animals; Aorta; Aspirin; Blood Platelets; Cattle; Clopidogrel; Endothelium, Vascular; Female; Ligation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Thionucleotides; Thrombin; Thromboplastin; Thrombosis; Ticlopidine; Vena Cava, Inferior | 1994 |
Binding of [3H]-2-methylthio ADP to rat platelets--effect of clopidogrel and ticlopidine.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Binding Sites; Blood Platelets; Clopidogrel; Female; In Vitro Techniques; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Ticlopidine | 1994 |
Combined ADP and thromboxane A2 antagonism prevents cyclic flow variations in stenosed and endothelium-injured arteries in nonhuman primates.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Constriction, Pathologic; Coronary Vessels; Dogs; Endothelium, Vascular; Female; Femoral Artery; Hemodynamics; Humans; In Vitro Techniques; Papio; Platelet Aggregation; Regional Blood Flow; Thromboxane A2; Ticlopidine | 1993 |
Experimental thrombosis on a collagen coated arterioarterial shunt in rats: a pharmacological model to study antithrombotic agents inhibiting thrombin formation and platelet deposition.
Topics: Animals; Anticoagulants; Arterio-Arterial Fistula; Aspirin; Carotid Artery Thrombosis; Clopidogrel; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Fibrin; Fibrinogen; Fibrinolytic Agents; Glass; Heparin; Hirudin Therapy; Hirudins; Male; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Polyethylenes; Rats; Rats, Wistar; Recombinant Proteins; Regional Blood Flow; Silicones; Thrombin; Ticlopidine | 1993 |
Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits.
Topics: Air; Animals; Arteries; Cell Division; Clopidogrel; Extracellular Matrix; Male; Microscopy, Electron, Scanning; Muscle, Smooth, Vascular; Platelet Adhesiveness; Rabbits; Ticlopidine; Wounds and Injuries | 1993 |
Potentiating effect of clopidogrel and SR 46349, a novel 5-HT2 antagonist, on streptokinase-induced thrombolysis in the rabbit.
Topics: Animals; Bleeding Time; Clopidogrel; Drug Synergism; Fibrinolytic Agents; Fluorobenzenes; Jugular Veins; Male; Phenols; Platelet Aggregation Inhibitors; Rabbits; Serotonin Antagonists; Streptokinase; Thrombolytic Therapy; Thrombosis; Ticlopidine | 1993 |
Purinoceptors on blood platelets: further pharmacological and clinical evidence to suggest the presence of two ADP receptors.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Female; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Receptors, Purinergic P2; Thionucleotides; Ticlopidine | 1995 |
Anti-platelet effects of clopidogrel in rat middle cerebral artery thrombosis model.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Clopidogrel; Intracranial Embolism and Thrombosis; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thrombin; Ticlopidine | 1995 |
Antithrombotic effects of TAK-029, a novel GPIIb/IIIa antagonist, in guinea pigs: comparative studies with ticlopidine, clopidogrel, aspirin, prostaglandin E1 and argatroban.
Topics: Alprostadil; Animals; Arginine; Aspirin; Clopidogrel; Dogs; Fibrinolytic Agents; Guanidines; Guinea Pigs; Humans; Macaca fascicularis; Male; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrazines; Sulfonamides; Ticlopidine | 1996 |
Ultrastructural studies of platelet aggregates from human subjects receiving clopidogrel and from a patient with an inherited defect of an ADP-dependent pathway of platelet activation.
Topics: Adenosine Diphosphate; Adult; Antigens, Human Platelet; Blood Platelets; Clopidogrel; Flow Cytometry; Humans; Immunohistochemistry; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Signal Transduction; Ticlopidine | 1996 |
CAPRIE trial.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 1997 |
CAPRIE trial.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Research Design; Ticlopidine; Treatment Outcome | 1997 |
CAPRIE trial.
Topics: Anemia, Aplastic; Cerebral Infarction; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 1997 |
CAPRIE trial.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Drug Costs; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 1997 |
CAPRIE trial.
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 1997 |
Aspirin versus clopidogrel: the wrong question?
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Humans; Ischemia; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Research Design; Ticlopidine; Treatment Outcome | 1997 |
Effect of clopidogrel treatment on ADP-induced phosphorylations in rat platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Female; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thionucleotides; Ticlopidine | 1997 |
Vasomodulatory action of clopidogrel and ticlopidine.
Topics: Animals; Aorta, Thoracic; Arachidonic Acid; Clopidogrel; Endothelin-1; In Vitro Techniques; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Rabbits; Rats; Serotonin; Ticlopidine; Vasoconstriction | 1997 |
Clopidogrel: a new safe and effective antiplatelet agent. But unanswered questions remain.
Topics: Arteriosclerosis; Aspirin; Cerebrovascular Disorders; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 1997 |
Antiplatelet and antithrombotic efficacy of SR 121787, a nonpeptide orally active GP IIb/IIIa antagonist, in rabbits: comparison with clopidogrel and aspirin.
Topics: Animals; Aspirin; Benzylamines; Clopidogrel; Hemodynamics; Hemostasis; Male; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Thiazoles; Thrombosis; Ticlopidine | 1997 |
Characterization of P2x1 purinoreceptors on rat platelets: effect of clopidogrel.
Topics: Adenosine Triphosphate; Animals; Blood Platelets; Clopidogrel; Female; Ligands; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Ticlopidine | 1997 |
[Myocardial infarct, stroke and vascular events reduced by a third].
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 1997 |
Angiogenesis inhibitor SR 25989 upregulates thrombospondin-1 expression in human vascular endothelial cells and foreskin fibroblasts.
Topics: Cell Cycle; Cell Division; Cells, Cultured; Clopidogrel; Endothelium, Vascular; Fibroblasts; Fibronectins; Humans; Neovascularization, Physiologic; Osteonectin; RNA, Messenger; Serum Albumin, Bovine; Skin; Tenascin; Thrombospondin 1; Ticlopidine; Tumor Suppressor Protein p53; Up-Regulation | 1997 |
Anticlotting drug approved.
Topics: Administration, Oral; Arteriosclerosis; Clopidogrel; Contraindications; Humans; Platelet Aggregation Inhibitors; Ticlopidine; United States; United States Food and Drug Administration | 1998 |
Clopidogrel approved on basis of CAPRIE study.
Topics: Arteriosclerosis; Clopidogrel; Drug Approval; Humans; Platelet Aggregation Inhibitors; Ticlopidine; United States; United States Food and Drug Administration | 1998 |
Role of P2Y1 purinoceptor in ADP-induced platelet activation.
Topics: Adenosine Diphosphate; Animals; Calcium; Clopidogrel; Humans; In Vitro Techniques; Platelet Activation; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Ticlopidine | 1998 |
Blocking platelets more: are we skating on thin ice?
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Cerebrovascular Disorders; Clopidogrel; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 1998 |
Secondary prevention of stroke--new trials.
Topics: Aged; Aspirin; Cerebrovascular Disorders; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Cardiovascular and Renal Advisory Panel of the FDA.
Topics: Cardiovascular Diseases; Clopidogrel; Humans; Kidney; Platelet Aggregation Inhibitors; Ticlopidine; United States; United States Food and Drug Administration | 1998 |
Clinical safety and efficacy of clopidogrel--implications of the Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) study for future management of atherosclerotic disease.
Topics: Arteriosclerosis; Aspirin; Atrial Fibrillation; Brain Ischemia; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine; United States; Vascular Diseases | 1998 |
Clopidogrel for reduction of atherosclerotic events.
Topics: Administration, Oral; Arteriosclerosis; Clinical Trials as Topic; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
[Thrombosis prophylaxis after stroke].
Topics: Anticoagulants; Aspirin; Cerebrovascular Disorders; Clopidogrel; Heparin; Humans; Middle Aged; Platelet Aggregation Inhibitors; Primary Prevention; Risk Factors; Thromboembolism; Thrombosis; Ticlopidine | 1998 |
[Prevention of thrombosis after ischemic cerebrovascular attack--new possibilities].
Topics: Brain Ischemia; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Humans; Intracranial Embolism and Thrombosis; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 1998 |
Clopidogrel and its use in stroke patients.
Topics: Cerebrovascular Disorders; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
[Secondary cardiovascular prevention: convincing evidence concerning clopidogrel].
Topics: Arteriosclerosis; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 1998 |
[Cardiovascular secondary prevention. Convincing results with Clopidogrel].
Topics: Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
The antiaggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several experimental models in the rabbit.
Topics: Animals; Aspirin; Clopidogrel; Constriction, Pathologic; Drug Synergism; Femoral Artery; Fibrinolytic Agents; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thrombosis; Ticlopidine | 1998 |
Aspirin and newer orally active antiplatelet agents in the treatment of the post-myocardial infarction patient.
Topics: Administration, Oral; Aspirin; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 1998 |
New antiplatelet agents.
Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Female; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Male; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Thrombolytic Therapy; Ticlopidine | 1998 |
Shifting paradigms of antiplatelet therapy: assessing new drugs versus old. Introduction.
Topics: Arteriosclerosis; Aspirin; Chemistry, Pharmaceutical; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Modulation of vasoconstriction by clopidogrel and ticlopidine.
Topics: Animals; Arteries; Clopidogrel; Dogs; Male; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticlopidine; Vasoconstriction | 1998 |
Effects of clopidogrel, aspirin and combined therapy in a porcine ex vivo model of high-shear induced stent thrombosis.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Bleeding Time; Blood Platelets; Clopidogrel; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Occlusion, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Swine; Ticlopidine | 1998 |
Clopidogrel inhibition of stent, graft, and vascular thrombogenesis with antithrombotic enhancement by aspirin in nonhuman primates.
Topics: Animals; Aspirin; Bleeding Time; Clopidogrel; Drug Interactions; Endarterectomy; Hemostasis; Heparin; Male; Papio; Platelet Aggregation Inhibitors; Polyethylene Terephthalates; Stents; Thrombosis; Ticlopidine | 1998 |
The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Calcium; Clopidogrel; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Ticlopidine | 1998 |
[Prevention in the 21st century. Athero-thrombosis and ischemic events].
Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Female; Forecasting; Humans; Male; Myocardial Ischemia; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 1998 |
Assay method for the carboxylic acid metabolite of clopidogrel in human plasma by gas chromatography-mass spectrometry.
Topics: Calibration; Carboxylic Acids; Clopidogrel; Gas Chromatography-Mass Spectrometry; Humans; Platelet Aggregation Inhibitors; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine | 1998 |
Rationale for antiplatelet therapy in patients with atherothrombotic disease.
Topics: Arteriosclerosis; Clopidogrel; Controlled Clinical Trials as Topic; Cyclooxygenase Inhibitors; Epoprostenol; Female; Fibrinolytic Agents; Humans; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Thrombosis; Ticlopidine | 1998 |
Specific inhibition of ADP-induced platelet aggregation by clopidogrel in vitro.
Topics: Adenosine Diphosphate; Alprostadil; Apyrase; Blood Platelets; Clopidogrel; Cyclic AMP; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Serum Albumin; Stereoisomerism; Ticlopidine; Time Factors | 1999 |
Relaxant effect of 2-methyl-thio-adenosine diphosphate on rat thoracic aorta: effect of clopidogrel.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aorta, Thoracic; Clopidogrel; Endothelium, Vascular; In Vitro Techniques; Isometric Contraction; Male; NG-Nitroarginine Methyl Ester; Phenylephrine; Platelet Aggregation Inhibitors; Rats; Receptors, Purinergic; Ticlopidine; Uridine Triphosphate; Vasodilation | 1999 |
[The CLASSICS Study: ClopidogreL+ASA vs. Ticlopidin+ASA in patients with stents].
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 1999 |
Clopidogrel: a novel antiplatelet agent.
Topics: Adenosine Diphosphate; Aspirin; Clopidogrel; Humans; Ischemia; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Diseases | 1999 |
[The CLASSICS Study: Clopidogrel plus ASA vs. Ticlopidin plus ASA in stent-patients].
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 1999 |
Effect of clopidogrel on thrombin generation in platelet-rich plasma in the rat.
Topics: Animals; Blood Platelets; Clopidogrel; Flow Cytometry; Male; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombin; Thrombosis; Ticlopidine | 1999 |
[Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation].
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 1999 |
Secondary stroke prevention with drugs: single or combined therapy?
Topics: Anticoagulants; Aspirin; Cerebrovascular Disorders; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Ticlopidine | 1999 |
Meeting highlights. Highlights of the 48th scientific sessions of the American College of Cardiology.
Topics: Abciximab; Alanine; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Antibodies, Monoclonal; Aspirin; Benzamidines; Biphenyl Compounds; Cardiology; Cardiovascular Agents; Clinical Trials as Topic; Clopidogrel; Combined Modality Therapy; Coronary Disease; Dalteparin; Defibrillators, Implantable; Double-Blind Method; Enalapril; Endothelial Growth Factors; Fatty Acids, Omega-3; Guanidines; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin Fab Fragments; Laser Therapy; Lymphokines; Metoprolol; Multicenter Studies as Topic; Myocardial Revascularization; Platelet Aggregation Inhibitors; Pyrrolidines; Randomized Controlled Trials as Topic; Simvastatin; Sodium-Hydrogen Exchangers; Stents; Sulfones; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vitamin E | 1999 |
Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Calcium; Clopidogrel; Cyclic AMP; Epinephrine; Female; Humans; Male; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Ticlopidine; Vasodilator Agents | 1999 |
Non-specific inhibition of ADP-induced platelet antiaggregation by clopidogrel in vitro.
Topics: Adenosine Diphosphate; Cells, Cultured; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Successful use of clopidogrel for cerebrovascular accident in a patient with suspected ticlopidine-induced hepatotoxicity.
Topics: Aged; Cerebrovascular Disorders; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans; Liver Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 1999 |
Flow cytometry analysis of intracellular VASP phosphorylation for the assessment of activating and inhibitory signal transduction pathways in human platelets--definition and detection of ticlopidine/clopidogrel effects.
Topics: Adult; Blood Platelets; Blood Proteins; Blotting, Western; Cell Adhesion Molecules; Clopidogrel; Evaluation Studies as Topic; Flow Cytometry; Humans; In Vitro Techniques; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Signal Transduction; Ticlopidine | 1999 |
Comparison of the antithrombotic effects of heparin, hirudin and clopidogrel according to the nature of the thrombogenic surface in an arterioarterial shunt in rats.
Topics: Animals; Clopidogrel; Disease Models, Animal; Female; Fibrinolytic Agents; Heparin; Hirudins; Rats; Rats, Wistar; Thrombosis; Ticlopidine | 1999 |
Effectiveness of aspirin and clopidogrel combination therapy in coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Disease; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine; Treatment Outcome | 1999 |
Using clopidogrel bisulfate: a new antiplatelet drug.
Topics: Arteriosclerosis; Clopidogrel; Drug Costs; Drug Interactions; Drug Monitoring; Humans; Patient Education as Topic; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Clopidogrel and membranous nephropathy.
Topics: Clopidogrel; Glomerulonephritis, Membranous; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 1999 |
Taming platelets in coronary stenting: ticlopidine out, clopidogrel in?
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Disease; Humans; Stents; Ticlopidine | 1999 |
[Creative mathematics with clopidogrel; exaggeration of the preventive effect by manufacturer].
Topics: Advertising; Clopidogrel; Data Interpretation, Statistical; Drug Industry; Humans; Myocardial Infarction; Netherlands; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 1999 |
Generalizing the results of clinical trials to actual practice: the example of clopidogrel therapy for the prevention of vascular events. CAPRA (CAPRIE Actual Practice Rates Analysis) Study Group. Clopidogrel versus Aspirin in Patients at Risk of Ischaemi
Topics: Aged; Arterial Occlusive Diseases; Aspirin; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Cohort Studies; Evidence-Based Medicine; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Risk; Saskatchewan; Ticlopidine; Treatment Outcome | 1999 |
[Creative mathematics with clopidogrel].
Topics: Advertising; Arteriosclerosis; Clopidogrel; Data Interpretation, Statistical; Drug Industry; Humans; Mathematics; Netherlands; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 1999 |
Thienopyridines: effects on cultured endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Aspirin; Calcimycin; Calcium; Cattle; Cell Line; Cell Survival; Cells, Cultured; Clopidogrel; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Epoprostenol; Humans; Nitrites; Platelet Aggregation Inhibitors; Pyridines; Ticlopidine; Time Factors; Umbilical Veins | 1999 |
Treatment and secondary prevention of stroke.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2000 |
Clopidogrel associated with acute arthritis.
Topics: Acute Disease; Aged; Arthritis; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2000 |
Studies published on clopidogrel-aspirin for coronary stent placement.
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Coronary Vessels; Drug Combinations; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine | 2000 |
Effects of clopidogrel on platelet activation and coagulation of non-anticoagulated rat blood under high shear stress.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Hemostatic Techniques; Male; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stress, Mechanical; Ticlopidine; Time Factors | 1999 |
Ex vivo--in vitro interaction between aspirin, clopidogrel, and the glycoprotein IIb/IIIa inhibitors abciximab and SR121566A.
Topics: Abciximab; Administration, Oral; Adult; Analysis of Variance; Antibodies, Monoclonal; Aspirin; Benzylamines; Bleeding Time; Clopidogrel; Drug Administration Schedule; Drug Interactions; Fibrinogen; Humans; Immunoglobulin Fab Fragments; Male; Nephelometry and Turbidimetry; P-Selectin; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Reference Values; Thiazoles; Ticlopidine | 2000 |
The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arteriovenous Shunt, Surgical; Binding, Competitive; Bleeding Time; Blood Platelets; Clopidogrel; Collagen; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Thiophenes; Thrombin; Thrombosis; Ticlopidine; Time Factors; Tritium | 2000 |
[Immortal aspirin....].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Fibrinolytic Agents; France; Germany; History, 19th Century; History, 20th Century; History, Ancient; Humans; Italy; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Ticlopidine; United Kingdom | 2000 |
[Clopidogrel--an expensive thrombocyte inhibitor with a small marginal benefit].
Topics: Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine | 2000 |
[Creative mathematics with clopidogrel; exaggeration of the preventive effect by the pharmaceutical company].
Topics: Advertising; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Clopidogrel; Data Interpretation, Statistical; Humans; Mathematics; Netherlands; Placebo Effect; Platelet Aggregation Inhibitors; Ticlopidine | 2000 |
[Platelet aggregation in spinal anesthesia].
Topics: Anesthesia, Spinal; Clopidogrel; Hematoma; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2000 |
Stent-assisted angioplasty of intracranial vertebrobasilar atherosclerosis: an initial experience.
Topics: Abciximab; Adult; Aged; Angiography; Angioplasty; Antibodies, Monoclonal; Anticoagulants; Aspirin; Basilar Artery; Cerebrovascular Circulation; Clopidogrel; Female; Follow-Up Studies; Heparin; Humans; Immunoglobulin Fab Fragments; Intracranial Arteriosclerosis; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Stents; Stroke; Subarachnoid Hemorrhage; Ticlopidine; Vertebral Artery; Vertebrobasilar Insufficiency; Warfarin | 2000 |
[Contribution of platelet aggregation inhibitors in the prevention of complications of atherothrombosis].
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Risk Factors; Thrombosis; Ticlopidine; Vascular Diseases | 2000 |
Clopidogrel-associated thrombotic thrombocytopenic purpura identified.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2000 |
Hemolytic uremic syndrome associated with clopidogrel: a case report.
Topics: Angina, Unstable; Clopidogrel; Hemolytic-Uremic Syndrome; Humans; Male; Middle Aged; Plasmapheresis; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2000 |
Unstable angina pectoris.
Topics: Angina, Unstable; Clopidogrel; Humans; Neutropenia; Platelet Aggregation Inhibitors; Ticlopidine | 2000 |
Reversible ageusia as an effect of clopidogrel treatment.
Topics: Aged; Ageusia; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2000 |
Thrombotic thrombocytopenic purpura associated with clopidogrel.
Topics: Adult; Aged; Clopidogrel; Fatal Outcome; Female; Humans; Male; Middle Aged; Plasma Exchange; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Recurrence; Ticlopidine | 2000 |
Thrombotic thrombocytopenic purpura and clopidogrel--a need for new approaches to drug safety.
Topics: Adverse Drug Reaction Reporting Systems; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Purpura, Thrombotic Thrombocytopenic; Ticlopidine; United States | 2000 |
Hemolytic uremic syndrome in a patient treated with clopidogrel.
Topics: Aged; Clopidogrel; Hemolytic-Uremic Syndrome; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2000 |
What have We learned from ESPRIT? What will we learn from TARGET?
Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Cohort Studies; Eptifibatide; Fibrinolytic Agents; Heparin; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Stents; Ticlopidine; Tirofiban; Tyrosine | 2000 |
Combination therapy with clopidogrel and aspirin after coronary stenting.
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2000 |
Consider this: It's too little!
Topics: Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2000 |
[ASA or clopidogrel?].
Topics: Aspirin; Clopidogrel; Controlled Clinical Trials as Topic; Drug Costs; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2000 |
Incidence of thrombocytopenia following coronary stent placement using abciximab plus clopidogrel or ticlopidine.
Topics: Abciximab; Adult; Aged; Antibodies, Monoclonal; Blood Vessel Prosthesis Implantation; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Thrombosis; Drug Therapy, Combination; Female; Graft Occlusion, Vascular; Humans; Immunoglobulin Fab Fragments; Incidence; Infusions, Intravenous; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Retrospective Studies; Stents; Thrombocytopenia; Thrombolytic Therapy; Ticlopidine | 2000 |
Clopidogrel-associated thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in a kidney/pancreas transplant recipient.
Topics: Adult; Clopidogrel; Coronary Disease; Cyclosporine; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Hemolytic-Uremic Syndrome; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Pancreas Transplantation; Plasmapheresis; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2000 |
Aspirin plus extended-release dipyridamole or clopidogrel compared with aspirin monotherapy for the prevention of recurrent ischemic stroke: a cost-effectiveness analysis.
Topics: Aspirin; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Recurrence; Stroke; Ticlopidine | 2000 |
Clopidogrel instead of ticlopidine after coronary stent placement: is the switch justified?
Topics: Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Thrombosis; Ticlopidine | 2000 |
Clopidogrel for prevention of major cardiac events after coronary stent implantation: 30-day and 6-month results in patients with smaller stents.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Disease; Cost-Benefit Analysis; Drug Costs; Equipment Design; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Registries; Stents; Ticlopidine | 2000 |
[Clopidogrel].
Topics: Arteriosclerosis; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2000 |
[On the debate on clopidogrel].
Topics: Clopidogrel; Controlled Clinical Trials as Topic; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2000 |
A pharmacodynamic study of clopidogrel in chronic hemodialysis patients.
Topics: Adenosine Diphosphate; Arterial Occlusive Diseases; Chronic Disease; Clopidogrel; Dose-Response Relationship, Drug; Hemostasis; Humans; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Renal Dialysis; Renal Insufficiency; Thrombosis; Ticlopidine | 2000 |
Isolated profound thrombocytopenia associated with clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Hypersensitivity; Follow-Up Studies; Humans; Hypersensitivity, Delayed; Immunoglobulins, Intravenous; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombocytopenia; Ticlopidine | 2000 |
Cost-effectiveness of new antiplatelet regimens used as secondary prevention of stroke or transient ischemic attack.
Topics: Aged; Aspirin; Clopidogrel; Cost-Benefit Analysis; Decision Trees; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Markov Chains; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Recurrence; Stroke; Ticlopidine | 2000 |
Risk of neutropenia with clopidogrel.
Topics: Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Disease; Graft Occlusion, Vascular; Humans; Neutropenia; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2000 |
[New antiplatelet agents].
Topics: Abciximab; Acetates; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Dipyridamole; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Ticlopidine; Tirofiban; Tyrosine | 2000 |
Clopidogrel and thrombotic thrombocytopenic purpura.
Topics: Clopidogrel; Drug Labeling; Humans; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Purpura, Thrombotic Thrombocytopenic; Ticlopidine; United States; United States Food and Drug Administration | 2000 |
Clopidogrel and thrombotic thrombocytopenic purpura.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Purpura, Thrombotic Thrombocytopenic; Ticlopidine; United States; United States Food and Drug Administration | 2000 |
Clopidogrel and thrombotic thrombocytopenic purpura.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2000 |
Clopidogrel and thrombotic thrombocytopenic purpura.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Platelet Count; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2000 |
Clopidogrel and thrombotic thrombocytopenic purpura.
Topics: Advertising; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Purpura, Thrombotic Thrombocytopenic; Ticlopidine; United States | 2000 |
[Calculation of costs of stroke, cost effectiveness of stroke units and secondary prevention in patients after a stroke, as recommended by revised CBO practice guideline 'Stroke'].
Topics: Age Factors; Aspirin; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Drug Costs; Health Care Costs; Humans; Intensive Care Units; Length of Stay; Models, Economic; Netherlands; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Sex Factors; Stroke; Ticlopidine | 2000 |
Clopidogrel and thrombotic thrombocytopenic purpura.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine; Time Factors | 2000 |
[Old and new platelet aggregation inhibitors: which to choose for prevention of stroke?].
Topics: Aspirin; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stroke; Ticlopidine | 2000 |
Very slow chiral inversion of clopidogrel in rats: a pharmacokinetic and mechanistic investigation.
Topics: Algorithms; Animals; Chromatography, High Pressure Liquid; Clopidogrel; Half-Life; Hepatocytes; Hydrolysis; In Vitro Techniques; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Stereoisomerism; Ticlopidine | 2000 |
Identification and biological activity of the active metabolite of clopidogrel.
Topics: Blood Platelets; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Structure-Activity Relationship; Ticlopidine | 2000 |
Clopidogrel but not ticlopidine produces an antiplatelet effect in the Yucatan minipig.
Topics: Animals; Clopidogrel; Platelet Aggregation; Platelet Aggregation Inhibitors; Swine, Miniature; Ticlopidine | 2000 |
Active-control trials: how would a new agent compare with placebo? A method illustrated with clopidogrel, aspirin, and placebo.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Odds Ratio; Placebos; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Febrile pancytopenia associated with clopidogrel.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Fever; Humans; Pancytopenia; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Combination therapy with aspirin plus clopidogrel versus aspirin plus ticlopidine for prevention of subacute thrombosis after successful native coronary stenting.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Thrombosis; Ticlopidine; Treatment Outcome; Ultrasonography, Interventional | 2001 |
Stasis ulcers refractory to therapy--accelerated healing by treatment with clopidogrel +/- dalteparin: a preliminary report.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Antiphospholipid Syndrome; Clopidogrel; Dalteparin; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombophilia; Ticlopidine; Treatment Outcome; Varicose Ulcer; Venous Thrombosis | 2001 |
Thrombolysis by thienopyridines and their congeners.
Topics: Animals; Clopidogrel; Extracorporeal Circulation; Fibrinolytic Agents; Humans; Male; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Ticlopidine | 2000 |
[2 platelet inhibitors administered at the same time. Improved prognosis in myocardial infarct?]].
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine | 2001 |
[Clopidogrel? Known or known?].
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Fatal aplastic anaemia associated with clopidogrel.
Topics: Aged; Aged, 80 and over; Anemia, Aplastic; Carotid Stenosis; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Newer antiplatelet therapies in stroke prevention.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2001 |
Platelet CD40 ligand (CD40L)--subcellular localization, regulation of expression, and inhibition by clopidogrel.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Antigens, CD; Blood Platelets; Calcimycin; Calcium; CD40 Ligand; Cells, Cultured; Clopidogrel; Collagen; Cytoplasmic Granules; Cytoskeleton; Gene Expression Regulation; Humans; Ionophores; Male; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tetraspanin 30; Thrombin; Ticlopidine | 2001 |
Activation of Gi-coupled receptors releases a tonic state of inhibited platelet aggregation.
Topics: Adaptation, Physiological; Adenosine Diphosphate; Adenosine Monophosphate; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Clopidogrel; Epinephrine; Female; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Hirudins; Humans; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Receptor Agonists; Ticlopidine | 2001 |
Results of CURE trial for acute coronary syndrome.
Topics: Clopidogrel; Cost-Benefit Analysis; Humans; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Risk; Stroke; Ticlopidine | 2001 |
P2y(12), a new platelet ADP receptor, target of clopidogrel.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Blood Platelets; CHO Cells; Clopidogrel; Cricetinae; Down-Regulation; Humans; Kinetics; Receptors, Purinergic P2; Ticlopidine; Transfection | 2001 |
Edge stenosis after intracoronary radiotherapy: angiographic, intravascular, and histological findings.
Topics: Aged; Angioplasty, Balloon, Laser-Assisted; Anticoagulants; Aspirin; Brachytherapy; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Coronary Stenosis; Humans; Hyperlipidemias; Hypertension; Iridium Radioisotopes; Male; Myocardial Revascularization; Recurrence; Reoperation; Stents; Ticlopidine | 2001 |
[Pharmacy clinics. Medication of the month. Clopidogrel (Plavix)].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Myocardial Ischemia; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2001 |
[Acute heart attacks. Prognosis can be further improved].
Topics: Adrenergic beta-Antagonists; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Survival Rate; Ticlopidine | 2001 |
[Pathophysiology of platelet activation and pharmacology of GPIIb/IIIa inhibitors].
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Eptifibatide; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Peptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Ticlopidine; Tirofiban; Tyrosine | 2001 |
[Optimal platelet inhibition therapy in unstable angina pectoris and after coronary interventions].
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Multicenter Studies as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Time Factors | 2001 |
CURE--clopidogrel's major advance.
Topics: Aspirin; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2001 |
Clopidogrel and aplastic anaemia.
Topics: Aged; Anemia, Aplastic; Clopidogrel; Fatal Outcome; Female; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
The inhibition of oxygen radical release from human neutrophils by resting platelets is reversed by administration of acetylsalicylic acid or clopidogrel.
Topics: Adult; Aspirin; Blood Platelets; Cell Respiration; Cells, Cultured; Clopidogrel; Female; Free Radicals; Humans; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
[Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery].
Topics: Aspirin; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine | 2001 |
Clinical application of procedural platelet monitoring during percutaneous coronary intervention among patients at increased bleeding risk.
Topics: Abciximab; Adult; Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Carotid Stenosis; Clopidogrel; Comorbidity; Coronary Artery Bypass; Drug Therapy, Combination; Female; Fibrinogen; Graft Occlusion, Vascular; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Microspheres; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Recurrence; Risk; Stents; Ticlopidine | 2001 |
Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Bleeding Time; Blood Coagulation; Blood Platelets; Cells, Cultured; Clopidogrel; Fibrinolytic Agents; Gene Targeting; Kinetics; Membrane Proteins; Mice; Mice, Knockout; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2001 |
[Toxic skin reaction to clopidogrel].
Topics: Aged; Clopidogrel; Drug Eruptions; Female; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Diffuse alveolar hemorrhage after clopidogrel use.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Hemorrhage; Humans; Lung Diseases; Male; Middle Aged; Platelet Aggregation Inhibitors; Radiography; Ticlopidine | 2001 |
Extensive thrombus prior to elective percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Thrombosis; Elective Surgical Procedures; Eptifibatide; Female; Heparin; Humans; Middle Aged; Peptides; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Current perspectives on British use of adjunctive therapies during coronary interventions.
Topics: Abciximab; Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Combined Modality Therapy; Coronary Disease; Heparin; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Patterns, Physicians'; Ticlopidine; United Kingdom | 2001 |
Radiation-induced glomerular thrombus formation and nephropathy are not prevented by the ADP receptor antagonist clopidogrel.
Topics: Animals; Apyrase; Clopidogrel; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Edetic Acid; Female; Fibrin Fibrinogen Degradation Products; Fibrinolytic Agents; Glomerular Filtration Rate; Image Processing, Computer-Assisted; Kidney Function Tests; Kidney Glomerulus; Mice; Mice, Inbred C3H; Mice, Nude; Purinergic P2 Receptor Antagonists; Radiation Injuries, Experimental; Radiation Tolerance; Thrombosis; Ticlopidine | 2001 |
Deaggregation is an integral component of the response of platelets to ADP in vitro: kinetic studies of literature and original data.
Topics: Adenosine Diphosphate; Binding, Competitive; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Humans; Kinetics; Membrane Proteins; Models, Theoretical; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Signal Transduction; Ticlopidine | 2001 |
Severe hypersensitivity associated with clopidogrel.
Topics: Cholecystitis; Clopidogrel; Drug Hypersensitivity; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Bench to bedside: the development of rapamycin and its application to stent restenosis.
Topics: Angioplasty, Balloon, Coronary; Animals; Calcineurin Inhibitors; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cell Movement; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Graft Occlusion, Vascular; Humans; Hyperplasia; Macromolecular Substances; Phosphotransferases (Alcohol Group Acceptor); Platelet Aggregation Inhibitors; Signal Transduction; Sirolimus; Stents; Tacrolimus; Tacrolimus Binding Protein 1A; Ticlopidine; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins; Tunica Media; Vascular Patency | 2001 |
Clopidogrel in invasive management of non-ST-elevation ACS.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Humans; Myocardial Ischemia; Myocardial Revascularization; Platelet Aggregation Inhibitors; Preoperative Care; Ticlopidine; Treatment Outcome | 2001 |
[Cost effectiveness of clopidogrel in secondary cardiovascular prevention: a cost-effectiveness analysis based on the Caprie Study].
Topics: Adult; Aged; Arterial Occlusive Diseases; Aspirin; Cerebral Hemorrhage; Cerebral Infarction; Clopidogrel; Cost-Benefit Analysis; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Assessment; Switzerland; Ticlopidine | 2001 |
Prevention of venous graft sclerosis with clopidogrel and aspirin combined with a mesh tubing in a dog model of arteriovenous bypass grafting.
Topics: Animals; Aspirin; Blood Vessel Prosthesis; Carotid Artery, Common; Clopidogrel; Dogs; Drug Therapy, Combination; Graft Occlusion, Vascular; Jugular Veins; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Effect of clopidogrel added to aspirin before percutaneous coronary intervention on the risk associated with C-reactive protein.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; C-Reactive Protein; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Ohio; Platelet Aggregation Inhibitors; Premedication; Registries; Stents; Survival Analysis; Ticlopidine; Treatment Outcome | 2001 |
Acute myocardial infarction 2000 treatment.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Primary Health Care; Thrombolytic Therapy; Ticlopidine; United States | 2001 |
Clopidogrel versus aspirin after cardiac surgery.
Topics: Aspirin; Clopidogrel; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Postoperative Care; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine; Treatment Outcome | 2001 |
Coronary stent thrombosis: insights from the porcine coronary stent model.
Topics: Animals; Anticoagulants; Aspirin; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Coronary Vessels; Drug Therapy, Combination; Heparin; Humans; Models, Animal; Myocardial Infarction; Stents; Swine; Ticlopidine | 2001 |
[Clopidogrel in acute coronary syndromes with non-ST elevation. Clinical implications of the CURE trial].
Topics: Angina, Unstable; Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Syndrome; Ticlopidine; Treatment Outcome | 2001 |
Coronary stent deployment in situs inversus.
Topics: Aged; Aspirin; Chest Pain; Clopidogrel; Coronary Artery Disease; Dextrocardia; Electrocardiography; Humans; Male; Situs Inversus; Stents; Ticlopidine | 2001 |
Effects of clopidogrel pretreatment before percutaneous coronary intervention in patients treated with glycoprotein IIb/IIIa inhibitors (abciximab or tirofiban).
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Coronary Disease; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2001 |
Statins do not affect platelet inhibition with clopidogrel during coronary stenting.
Topics: Aged; Clopidogrel; Coronary Disease; Coronary Vessels; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2001 |
Clopidogrel and side effects.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2001 |
Antithrombotic drugs for secondary stroke prophylaxis--a comment.
Topics: Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Dipyridamole; Drug Combinations; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2001 |
Antiplatelet therapy: a neurology perspective.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Humans; Neurology; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; United States | 2000 |
Clinical and economic implications of atherosclerosis.
Topics: Arteriosclerosis; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; United States | 2000 |
Clinical and economic implications of atherosclerosis.
Topics: Arteriosclerosis; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; United States | 2000 |
Antiplatelet therapy: a neurology perspective.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Humans; Neurology; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; United States | 2000 |
Antiplatelet therapy: a vascular medicine perspective.
Topics: Aspirin; Clopidogrel; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine; United States | 2000 |
Dual antiplatelet therapy with clopidogrel and aspirin after carotid artery stenting.
Topics: Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Clopidogrel; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Implantation; Stents; Stroke; Survival Analysis; Ticlopidine | 2001 |
Aspirin plus clopidogrel for everyone: panacea comes true in the 21st century.
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Prosthesis Implantation; Stents; Ticlopidine | 2001 |
Haemorrhage associated with combined clopidogrel and aspirin therapy.
Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Current strategies of secondary prevention after a cerebrovascular event: the Vienna stroke registry.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Austria; Clopidogrel; Cohort Studies; Comorbidity; Contraindications; Cross-Sectional Studies; Dipyridamole; Drug Combinations; Female; Humans; Intracranial Embolism; Ischemic Attack, Transient; Logistic Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Registries; Secondary Prevention; Stroke; Ticlopidine | 2001 |
Quality care outcomes in cardiac surgery: the role of evidence-based practice.
Topics: Aged; Blood Loss, Surgical; California; Clopidogrel; Coronary Artery Bypass; Evidence-Based Medicine; Female; Health Care Costs; Humans; Male; Nurse Practitioners; Nursing Evaluation Research; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Evaluating the risks of therapies for acute coronary syndromes.
Topics: Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine | 2001 |
Effect of 300- and 450-mg clopidogrel loading doses on membrane and soluble P-selectin in patients undergoing coronary stent implantation.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Apyrase; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Thrombosis; Ticlopidine | 2002 |
Intracerebral hemorrhage following possible interaction between celecoxib and clopidogrel.
Topics: Aged; Aged, 80 and over; Celecoxib; Cerebral Hemorrhage; Clopidogrel; Cyclooxygenase Inhibitors; Drug Interactions; Female; Humans; Platelet Aggregation Inhibitors; Pyrazoles; Sulfonamides; Ticlopidine; Tomography, X-Ray Computed | 2001 |
Treatment of acute coronary syndromes.
Topics: Acute Disease; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Meta-Analysis as Topic; Myocardial Ischemia; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2002 |
Treatment of acute coronary syndromes.
Topics: Acute Disease; Aspirin; Clopidogrel; Combined Modality Therapy; Drug Therapy, Combination; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Stents; Ticlopidine | 2002 |
Treatment of acute coronary syndromes.
Topics: Acute Disease; Aspirin; Clopidogrel; Creatine Kinase; Creatine Kinase, MB Form; Drug Therapy, Combination; Humans; Isoenzymes; Myocardial Ischemia; Myocardial Revascularization; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Troponin | 2002 |
Treatment of acute coronary syndromes.
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine | 2002 |
Aspirin versus clopidogrel for synthetic graft patency after peripheral arterial bypass grafting.
Topics: Arteries; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Graft Occlusion, Vascular; Humans; Male; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Patency | 2001 |
Effect of clopidogrel on bleeding after coronary artery bypass surgery.
Topics: Aspirin; Blood Transfusion; Case-Control Studies; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Humans; Incidence; Logistic Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Reoperation; Risk Factors; Statistics, Nonparametric; Tennessee; Ticlopidine | 2001 |
OPCAB therapy survey: off-pump clopidogrel, aspirin or both therapy survey.
Topics: Anticoagulants; Aspirin; Canada; Cardiology; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Data Collection; Drug Therapy, Combination; Humans; Intraoperative Complications; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine; Treatment Outcome; United States | 2001 |
Clopidogrel and percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Disease; Double-Blind Method; Humans; Platelet Aggregation Inhibitors; Premedication; Pyridines; Research Design; Stents; Survival Analysis; Ticlopidine; Treatment Outcome | 2002 |
Thrombostatin inhibits cyclic flow variations in stenosed canine coronary arteries.
Topics: Animals; Aspirin; Blood Coagulation Tests; Bradykinin; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Evaluation; Metabolic Clearance Rate; Peptide Fragments; Platelet Function Tests; Regional Blood Flow; Therapeutic Equivalency; Ticlopidine; Time Factors | 2001 |
Clopidogrel and recurrent severe haematuria in a patient with paraplegia.
Topics: Clopidogrel; Hematuria; Humans; Male; Middle Aged; Paraplegia; Platelet Aggregation Inhibitors; Recurrence; Severity of Illness Index; Ticlopidine | 2002 |
Thrombocytopenia and purpura-like lesions associated with clopidogrel.
Topics: Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purpura, Thrombocytopenic; Ticlopidine; Treatment Failure | 2001 |
Case report: successful pregnancy and delivery after myocardial infarction and essential thrombocythemia treated with clopidrogel.
Topics: Adult; Clopidogrel; Coronary Artery Bypass; Female; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Outcome; Thrombocytosis; Ticlopidine | 2001 |
Short-term inhibition of ADP-induced platelet aggregation by clopidogrel ameliorates radiation-induced toxicity in rat small intestine.
Topics: Adenosine Diphosphate; Animals; Chemotaxis, Leukocyte; Clopidogrel; Collagen; Endothelium, Vascular; Enteritis; Extracellular Matrix; Fibrosis; Gastrointestinal Hemorrhage; Intestine, Small; Male; Muscle, Smooth; Neutrophils; Platelet Aggregation; Platelet Aggregation Inhibitors; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ticlopidine; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Clopidogrel--a myocardial infarction CURE?
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2001 |
Close relationship between the platelet activation marker CD62 and the granular release of platelet-derived growth factor.
Topics: Abciximab; Adult; Antibodies, Monoclonal; Blood Platelets; Clopidogrel; Cytoplasmic Granules; Diabetes Mellitus; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Male; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet-Derived Growth Factor; Ticlopidine | 2002 |
Anti-angiogenic effects of the thienopyridine SR 25989 in vitro and in vivo in a murine pulmonary metastasis model.
Topics: Angiogenesis Inhibitors; Animals; Aorta; Cell Division; Clopidogrel; Disease Models, Animal; Foot; Gene Expression Regulation; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Microcirculation; Neoplasm Metastasis; Neoplasms, Experimental; Neovascularization, Pathologic; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Skin Neoplasms; Thrombospondin 1; Ticlopidine; Tumor Cells, Cultured | 2002 |
[Massive rhabdomyolysis associated with the use of cerivastatin monotherapy].
Topics: Anticholesteremic Agents; Anuria; Clopidogrel; Coronary Artery Bypass; Humans; Hypercholesterolemia; Intracranial Thrombosis; Male; Middle Aged; Muscle Weakness; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Pyridines; Rhabdomyolysis; Ticlopidine | 2001 |
[Criteria for Plavix supplementation].
Topics: Clopidogrel; Controlled Clinical Trials as Topic; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2002 |
Oral anticoagulation for acute coronary syndromes.
Topics: Administration, Oral; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Clopidogrel; Controlled Clinical Trials as Topic; Diabetes Complications; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Humans; International Normalized Ratio; Male; Middle Aged; Myocardial Infarction; Patient Care Planning; Risk Factors; Stroke; Thrombosis; Ticlopidine; Warfarin | 2002 |
Clopidogrel-induced qualitative changes in thrombus formation correlate with stent patency in injured pig cervical arteries.
Topics: Animals; Arteries; Cervix Uteri; Clopidogrel; Female; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Swine; Ticlopidine | 2002 |
Guidelines for acute coronary syndrome without ST elevation.
Topics: Clopidogrel; Coronary Disease; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Ticlopidine | 2002 |
[Clopidrogel in Acute Coronary Syndromes with Non-ST Elevation].
Topics: Acute Disease; Clopidogrel; Coronary Disease; Electrocardiography; Humans; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2002 |
Careless talk may cost lives in attributing adverse events to ADP receptor antagonists.
Topics: Arthritis; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticlopidine | 2002 |
Same-day transradial outpatient stenting with a 6-hr course of glycoprotein IIb/IIIa receptor blockade: a feasibility study.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Angioplasty, Balloon, Coronary; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Creatine Kinase; Electrocardiography; Feasibility Studies; Female; Follow-Up Studies; Humans; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Stroke Volume; Ticlopidine; Time Factors; Treatment Outcome | 2002 |
A validated LC method for the determination of clopidogrel in pharmaceutical preparations.
Topics: Calibration; Chromatography, High Pressure Liquid; Clopidogrel; Drug Industry; Hydrogen-Ion Concentration; Indicators and Reagents; Platelet Aggregation Inhibitors; Reference Standards; Reproducibility of Results; Solvents; Spectrophotometry, Ultraviolet; Tablets; Ticlopidine | 2002 |
[Two platelet inhibitors after acute coronary syndrome. Many colleagues are not aware of this].
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Survival Rate; Ticlopidine | 2002 |
The CURE trial: using clopidogrel in acute coronary syndromes without ST-segment elevation.
Topics: Angina Pectoris; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Syndrome; Ticlopidine | 2002 |
Unstable angina guidelines expand use of clopidogrel, enoxaparin.
Topics: Angina, Unstable; Clopidogrel; Enoxaparin; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Ticlopidine | 2002 |
Combined therapy with clopidogrel and aspirin significantly increases the bleeding time through a synergistic antiplatelet action.
Topics: Adult; Aspirin; Bleeding Time; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2002 |
Cost effectiveness of aspirin, clopidogrel, or both for secondary prevention of coronary heart disease.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Computer Simulation; Coronary Disease; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Humans; Middle Aged; Models, Econometric; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Ticlopidine | 2002 |
When increased therapeutic benefit comes at increased cost.
Topics: Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Drug Costs; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Ticlopidine | 2002 |
[Clopidogrel probably induced hepatic toxicity].
Topics: Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2002 |
[Risk improves effectiveness. Proper administration of platelet aggregation inhibitors].
Topics: Aspirin; Cerebral Infarction; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Ticlopidine; Treatment Outcome | 2002 |
Cardiac surgery in an era of antiplatelet therapies: generating new evidence.
Topics: Awards and Prizes; California; Clopidogrel; Evidence-Based Medicine; Humans; Nursing Research; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Thoracic Surgical Procedures; Ticlopidine | 2002 |
[Subarachnoid hemorrhage and clopidogrel].
Topics: Aged; Cerebral Angiography; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Subarachnoid Hemorrhage; Ticlopidine; Tomography, X-Ray Computed | 2002 |
[Platelet antiaggregation treatment in the aftermath of GUSTO IV, TARGET, TACTICS, and CURE trials].
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Coronary Artery Bypass; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Ticlopidine; Time Factors; Tirofiban; Tyrosine | 2002 |
[2002 Update of the Guidelines of the Spanish Society of Cardiology for Unstable Angina/Without ST-Segment Elevation Myocardial Infarction].
Topics: Angina, Unstable; Chest Pain; Clopidogrel; Electrocardiography; Heparin, Low-Molecular-Weight; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine | 2002 |
[New US guidelines. Myocardial infarct is now treated more aggressively].
Topics: Angina, Unstable; Aspirin; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine; United States | 2002 |
Effect of loading with clopidogrel at the time of coronary stenting on platelet aggregation and glycoprotein IIb/IIIa expression and platelet-leukocyte aggregate formation.
Topics: Blood Platelets; Cell Adhesion; Clopidogrel; Humans; Leukocytes; Myocardial Infarction; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2002 |
Ambulatory use of ticlopidine and clopidogrel in association with percutaneous coronary revascularization procedures in a national managed care organization.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2002 |
Clopidogrel as an antiplatelet agent in transplant heart coronary stenting.
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Heart Transplantation; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2002 |
Aspirin should be first-line antiplatelet therapy in the secondary prevention of stroke.
Topics: Aspirin; Clopidogrel; Dipyridamole; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine; Treatment Outcome | 2002 |
Aspirin therapy should be first-line treatment in secondary prevention of stroke--against.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk; Stroke; Ticlopidine; Treatment Outcome | 2002 |
Aspirin therapy should be first line: probably, but watch this space.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Synergism; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2002 |
Thrombotic thrombocytopenic purpura associated with clopidogrel: further evaluation.
Topics: Bayes Theorem; Causality; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2002 |
Inhibition of plasma-dependent monocyte chemokinesis and cytokine-triggered endothelial activation for neutrophil transmigration by administration of clopidogrel in man.
Topics: Adult; Biomarkers; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Chemotaxis, Leukocyte; Clopidogrel; Cytokines; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Male; Monocytes; Neutrophils; Platelet Aggregation Inhibitors; Ticlopidine; Umbilical Veins | 2002 |
Life-threatening haemorrhage after extracorporeal shockwave lithotripsy in a patient taking clopidogrel.
Topics: Clopidogrel; Hematoma; Hemorrhage; Humans; Lithotripsy; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Ureteral Calculi | 2002 |
Clopidogrel inhibits shear-induced platelet function.
Topics: Adult; Blood Platelets; Clopidogrel; Drug Evaluation; Female; Humans; Male; Perfusion; Platelet Activation; Platelet Function Tests; Stress, Mechanical; Ticlopidine | 2002 |
Abciximab-induced thrombocytopenia.
Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Diagnosis, Differential; Hemolytic-Uremic Syndrome; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Thrombocytopenia; Ticlopidine | 2002 |
Acute peripheral arterial ischemia and suspected aortic dissection: usefulness of transesophageal echocardiography in differential diagnosis with aortic thrombosis.
Topics: Acute Disease; Adult; Aged; Amputation, Surgical; Anticoagulants; Aortic Diseases; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Diagnosis, Differential; Echocardiography, Transesophageal; Female; Follow-Up Studies; Humans; Ischemia; Leg; Male; Middle Aged; Spain; Thrombectomy; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Warfarin | 2002 |
[Long-term anticoagulation after bypass operation].
Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Humans; Long-Term Care; Platelet Aggregation Inhibitors; Postoperative Complications; Recurrence; Ticlopidine | 2002 |
New guidelines for unstable angina. What you and your doctor need to know when chest pain worsens.
Topics: Angina, Unstable; Clinical Competence; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Humans; Outcome and Process Assessment, Health Care; Patient Education as Topic; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine; Treatment Outcome | 2002 |
Evidence-based risk stratification to target therapies in acute coronary syndromes.
Topics: Acute Disease; Angina Pectoris; Anticoagulants; Biomarkers; Cardiac Catheterization; Clopidogrel; Coronary Disease; Electrocardiography; Enoxaparin; Evidence-Based Medicine; Fibrinolytic Agents; Humans; Myocardial Infarction; Risk Assessment; Risk Factors; Severity of Illness Index; Ticlopidine; Troponin | 2002 |
CURE works patients with acute coronary syndromes at all risk levels.
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk; Risk Assessment; Secondary Prevention; Ticlopidine | 2002 |
New antiplatelet agents and prosthetic heart valves.
Topics: Abciximab; Aged; Antibodies, Monoclonal; Clopidogrel; Female; Heart Valve Prosthesis Implantation; Humans; Immunoglobulin Fab Fragments; Infant; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Thromboembolism; Ticlopidine | 2002 |
Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Blood Platelets; Cell Adhesion; Clopidogrel; Drug Therapy, Combination; Female; Humans; Leukocytes; Male; Membrane Proteins; Middle Aged; Myocardial Ischemia; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2002 |
Acute pulmonary embolism: don't ignore the platelet.
Topics: Acute Disease; Animals; Anticoagulants; Aspirin; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pulmonary Embolism; Secondary Prevention; Ticlopidine | 2002 |
ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction--2002: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidel
Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Biomarkers; Clopidogrel; Disease Management; Drug Therapy, Combination; Electrocardiography; Eptifibatide; Female; Health Behavior; Hemorrhage; Humans; Hypolipidemic Agents; Immunoglobulin Fab Fragments; Male; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Ticlopidine; Tirofiban; Tyrosine | 2002 |
TTP/HUS occurring in a simultaneous pancreas/kidney transplant recipient after clopidogrel treatment: evidence of a nonimmunological etiology.
Topics: Calcineurin; Clopidogrel; Graft Rejection; Hemolytic-Uremic Syndrome; Humans; Kidney Transplantation; Male; Middle Aged; Pancreas Transplantation; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2002 |
Therapy of Sneddon syndrome.
Topics: Adult; Antibodies, Antiphospholipid; Anticonvulsants; Aspirin; Azathioprine; Clopidogrel; Drug Therapy, Combination; Epilepsy; Female; Humans; Immunosuppressive Agents; Platelet Aggregation Inhibitors; Sneddon Syndrome; Ticlopidine; Valproic Acid | 2002 |
Large intracoronary thrombi with good TIMI flow during acute myocardial infarction: four cases of successful aggressive medical management in patients without angiographically detectable coronary atherosclerosis.
Topics: Abciximab; Adult; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Coronary Circulation; Coronary Thrombosis; Drug Therapy, Combination; Female; Heparin; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2002 |
Structure and stereochemistry of the active metabolite of clopidogrel.
Topics: Acrylonitrile; Biotransformation; Blood Platelets; Clopidogrel; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Models, Molecular; Molecular Conformation; Platelet Aggregation Inhibitors; Stereoisomerism; Ticlopidine | 2002 |
Clinical implications of percutaneous coronary intervention-clopidogrel in unstable angina to prevent recurrent events (PCI-CURE) study: a US perspective.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Retrospective Studies; Secondary Prevention; Ticlopidine; Time Factors; United States | 2002 |
Physical training for intermittent claudication: a comparison of structured rehabilitation versus home-based training.
Topics: Aged; Aged, 80 and over; Clopidogrel; Exercise Therapy; Exercise Tolerance; Female; Follow-Up Studies; Home Care Services; Humans; Intermittent Claudication; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prevalence; Rehabilitation Centers; Safety; Ticlopidine; Time Factors; Treatment Outcome; Walking | 2002 |
Authors' refute careless talk about ADP receptor antagonists.
Topics: Arthritis; Attitude of Health Personnel; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2002 |
Clopidogrel plus aspirin for stroke prevention.
Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Follow-Up Studies; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2002 |
Effects of combined therapy of clopidogrel and aspirin in preventing thrombus formation on mechanical heart valves in an ex vivo rabbit model.
Topics: Animals; Aspirin; Clopidogrel; Drug Evaluation, Preclinical; Drug Therapy, Combination; Heart Valve Prosthesis; In Vitro Techniques; Male; Microscopy, Electron; Rabbits; Thrombosis; Ticlopidine; Warfarin | 2002 |
A partial CURE for acute coronary syndromes--but how did it happen?
Topics: Angina, Unstable; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2002 |
[Indications of treatment with clopidogrel in the guidelines of the Spanish Society of Cardiology for unstable angina/non-ST-segment elevation acute myocardial infarction].
Topics: Angina, Unstable; Clopidogrel; Electrocardiography; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2002 |
Frequency and correlates of coronary stent thrombosis in the modern era: analysis of a single center registry.
Topics: Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2002 |
New treatment guidelines for unstable angina/non-ST-segment elevation myocardial infartion.
Topics: Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Heparin, Low-Molecular-Weight; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Ticlopidine | 2002 |
[New guidelines in acute coronary syndrome. Clopidogrel for nine months is recommended].
Topics: Angina, Unstable; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Survival Rate; Ticlopidine | 2002 |
Serious adverse vascular events associated with perioperative interruption of antiplatelet and anticoagulant therapy.
Topics: Aged; Anticoagulants; Aspirin; Carcinoma, Basal Cell; Clopidogrel; Drug Administration Schedule; Female; Heparin, Low-Molecular-Weight; Humans; Mohs Surgery; Nose Neoplasms; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Guidelines as Topic; Skin Neoplasms; Ticlopidine; Venous Thrombosis | 2002 |
The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Atorvastatin; Catalysis; Clopidogrel; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Isoenzymes; Male; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Pyrroles; Rats; Rats, Inbred F344; Spodoptera; Ticlopidine | 2003 |
Monitoring of antiplatelet therapy with the PFA-100 in peripheral angioplasty patients.
Topics: Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Arterial Occlusive Diseases; Blood Platelets; Clopidogrel; Coronary Disease; Coronary Restenosis; Drug Monitoring; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2002 |
Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease.
Topics: Blood Platelets; Cell Size; Clopidogrel; Coronary Disease; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2003 |
In vivo comparative antithrombotic effects of ioxaglate and iohexol and interaction with the platelet antiaggregant clopidogrel.
Topics: Animals; Carotid Artery Thrombosis; Clopidogrel; Contrast Media; Drug Synergism; Iohexol; Ioxaglic Acid; Male; Models, Animal; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Ticlopidine | 2003 |
Synthesis and thrombolytic activity of new thienopyrimidinone derivatives.
Topics: Animals; Arteries; Clopidogrel; Extracorporeal Circulation; Fibrinolytic Agents; Pyridones; Rats; Rats, Wistar; Thrombosis; Ticlopidine | 2002 |
Thrombophilic causes of retinal vascular thrombosis: etiology and treatment outcomes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clinical Laboratory Techniques; Clopidogrel; Dalteparin; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retinal Diseases; Retinal Vessels; Thrombophilia; Thrombosis; Ticlopidine; Treatment Outcome | 2002 |
Effect of clopidogrel on platelet aggregation and plasma concentration of fibrinogen in subjects with cerebral or coronary atherosclerotic disease.
Topics: Clopidogrel; Coronary Artery Disease; Fibrinogen; Humans; Intracranial Arteriosclerosis; Platelet Aggregation; Ticlopidine | 2002 |
Clopidogrel and rhabdomyolysis after heart transplantation.
Topics: Clopidogrel; Drug Interactions; Heart Transplantation; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Rhabdomyolysis; Ticlopidine | 2003 |
[In acute coronary syndrome. Seize platelets with pliers].
Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Syndrome; Ticlopidine; Time Factors | 2002 |
Clopidogrel-associated angioedema.
Topics: Aged; Angioedema; Clopidogrel; Coronary Disease; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Clopidogrel-associated leukopenia.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Leukopenia; Male; Middle Aged; Ticlopidine | 2003 |
Brachytherapy for renal artery in-stent restenosis.
Topics: Aged; Angioplasty, Balloon; Brachytherapy; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Recurrence; Renal Artery Obstruction; Stents; Ticlopidine | 2003 |
Optimal treatment and current situation in reperfusion after thrombolysis for acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Angioplasty; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Clopidogrel; Electrocardiography; Fibrinolytic Agents; Heparin; Humans; Myocardial Infarction; Myocardial Reperfusion; Nitroprusside; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombin; Thrombolytic Therapy; Ticlopidine | 2002 |
Aspirin, clopidogrel, or both for secondary prevention of coronary disease.
Topics: Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Drug Costs; Drug Industry; Fees, Pharmaceutical; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Drug interactions: gasoline and matches.
Topics: Atorvastatin; Cardiovascular Agents; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Databases, Factual; Drug Interactions; Heptanoic Acids; Pyrroles; Ticlopidine | 2003 |
Aspirin, clopidogrel, or both for secondary prevention of coronary disease.
Topics: Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Data Interpretation, Statistical; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2003 |
Aspirin, clopidogrel, or both for secondary prevention of coronary disease.
Topics: Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Data Interpretation, Statistical; Drug Costs; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2003 |
Aspirin, clopidogrel, or both for secondary prevention of coronary disease.
Topics: Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Drug Costs; Drug Industry; Fees, Pharmaceutical; Health Expenditures; Humans; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Ticlopidine | 2003 |
Aspirin, clopidogrel, or both for secondary prevention of coronary disease.
Topics: Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Humans; Medically Uninsured; Platelet Aggregation Inhibitors; Ticlopidine; United States | 2003 |
Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP.
Topics: Adenosine Diphosphate; Adolescent; Adult; Benzylamines; Blood Platelets; Clopidogrel; Electrophoresis, Polyacrylamide Gel; Humans; Male; Membrane Proteins; Phosphorylation; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serine; Signal Transduction; Thiazoles; Thionucleotides; Threonine; Ticlopidine; Tyrosine | 2003 |
Effect of atorvastatin and clopidogrel on cellular immune function.
Topics: Adult; Atorvastatin; Clopidogrel; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunity, Cellular; Immunosuppressive Agents; In Vitro Techniques; Leukocyte Count; Lymphocyte Activation; Lymphocyte Subsets; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2003 |
Onset and extent of platelet inhibition by clopidogrel loading in patients undergoing elective coronary stenting: the Plavix Reduction Of New Thrombus Occurrence (PRONTO) trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Antigens, CD; Clopidogrel; Collagen; Coronary Disease; Coronary Thrombosis; Drug Administration Schedule; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Single-Blind Method; Stents; Tetraspanin 24; Ticlopidine | 2003 |
Antiplatelet effects of angiotensin-converting enzyme inhibitors compared with aspirin and clopidogrel: a pilot study with whole-blood aggregometry.
Topics: Adenosine Diphosphate; Adult; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Case-Control Studies; Clopidogrel; Coronary Disease; Female; Humans; Hypertension; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2003 |
Effects of clopidogrel and ticlopidine on experimental diabetic ischemic retinopathy in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Clopidogrel; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dose-Response Relationship, Drug; Male; Nitrates; Nitric Oxide; Nitrites; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Retinal Vessels; Thromboxane B2; Ticlopidine | 2003 |
Pharmacological treatment of acute coronary syndromes.
Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Syndrome; Ticlopidine | 2003 |
Access to new cardiovascular therapies in Canadian hospitals: a national survey of the formulary process.
Topics: Abciximab; Antibodies, Monoclonal; Canada; Cardiovascular Agents; Clopidogrel; Dalteparin; Data Collection; Drug Utilization; Enoxaparin; Eptifibatide; Formularies, Hospital as Topic; Health Services Accessibility; Hematologic Agents; Humans; Immunoglobulin Fab Fragments; Peptides; Pharmacy and Therapeutics Committee; Ticlopidine; Tirofiban; Tyrosine | 2003 |
[Clopidogrel-induced hepatotoxicity].
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans; Liver Function Tests; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2003 |
In vivo blockade of platelet ADP receptor P2Y12 reduces embolus and thrombus formation but not thrombus stability.
Topics: Adenosine Monophosphate; Administration, Oral; Animals; Blood Platelets; Calcium; Clopidogrel; Female; Male; Membrane Proteins; Platelet Activation; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2Y12; Thrombin; Thromboembolism; Ticlopidine | 2003 |
[After the heart catheter. 2 thrombocyte inhibitors for a whole year?].
Topics: Aspirin; Cardiac Catheterization; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Long-Term Care; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2003 |
Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet-leukocyte aggregates in patients with atherosclerotic vascular disease.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Cross-Sectional Studies; Drug Therapy, Combination; Dual Specificity Phosphatase 2; Female; Flow Cytometry; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Ticlopidine | 2003 |
Spontaneous hemarthrosis of the knee associated with clopidogrel and aspirin treatment.
Topics: Aged; Angina, Unstable; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Coagulation Tests; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Hemarthrosis; Humans; Male; Myocardial Infarction; Osteoarthritis, Knee; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Risk Factors; Ticlopidine | 2003 |
Is aspirin still the antiplatelet drug of choice for patients with peripheral arterial disease?
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Antiplatelet drug works better if used longer.
Topics: Angioplasty; Clopidogrel; Follow-Up Studies; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2003 |
I'm a 65-year-old man with high blood pressure and a family history of stroke. Which stroke-prevention medication would be better for me--aspirin or clopidogrel (Plavix)?
Topics: Aged; Aspirin; Clopidogrel; Family Health; Humans; Hypertension; Life Style; Male; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2003 |
[Subarachnoid hemorrhage and clopidogrel].
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Subarachnoid Hemorrhage; Ticlopidine | 2003 |
[New antiaggregants and their importance for the practitioner].
Topics: Abciximab; Administration, Oral; Adult; Anesthesia, Spinal; Antibodies, Monoclonal; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Contraindications; Drug Therapy, Combination; Eptifibatide; Female; Fibrinolytic Agents; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Peptides; Placebos; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pregnancy; Ticlopidine; Tirofiban; Tyrosine | 2003 |
[Anticoagulation and antiaggregation in cardiac patients].
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Heart Valve Prosthesis; Hemorrhage; Humans; Myocardial Infarction; Placebos; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Primary Prevention; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Thromboembolism; Ticlopidine | 2003 |
[Anticoagulation and antiaggregation in neurological patients].
Topics: Acute Disease; Administration, Oral; Aged; Anticoagulants; Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Humans; Meta-Analysis as Topic; Middle Aged; Placebos; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Stroke; Ticlopidine; Warfarin | 2003 |
[Anticoagulation and antiaggregation in patients with peripheral arterial occlusive diseases].
Topics: Administration, Oral; Angioplasty, Balloon; Anticoagulants; Arterial Occlusive Diseases; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Confidence Intervals; Dipyridamole; Drug Therapy, Combination; Embolectomy; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; Iloprost; Intermittent Claudication; Leg; Meta-Analysis as Topic; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Thrombectomy; Ticlopidine; Time Factors; Vitamin K | 2003 |
The IST registry.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Beta Particles; Brachytherapy; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Gamma Rays; Germany; Humans; Internet; Placebos; Platelet Aggregation Inhibitors; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Registries; Stents; Thrombosis; Ticlopidine; Time Factors | 2002 |
Introduction to "Optimizing management of non-ST-segment elevation acute coronary syndromes". Harmonizing advances in mechanical and pharmacologic intervention.
Topics: Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Cardiac Catheterization; Clopidogrel; Coronary Thrombosis; Electrocardiography; Eptifibatide; Humans; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Ticlopidine | 2003 |
[Off-label use of clopidogrel after coronary stent implantation in Germany: optional or mandatory?].
Topics: Aspirin; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Drug Approval; Drug Costs; Drug Prescriptions; Drug Therapy, Combination; Drugs, Investigational; Financing, Personal; Germany; Humans; National Health Programs; Randomized Controlled Trials as Topic; Stents; Ticlopidine; Treatment Outcome | 2003 |
Massive hemorrhage during radiofrequency ablation of a pulmonary neoplasm.
Topics: Catheter Ablation; Clopidogrel; Hemorrhage; Humans; Intraoperative Complications; Lung Neoplasms; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2003 |
Clopidogrel bisulphate-induced photosensitive lichenoid eruption: first report.
Topics: Clopidogrel; Female; Humans; Lichenoid Eruptions; Middle Aged; Photosensitivity Disorders; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2003 |
Are antiplatelet effects of clopidogrel inhibited by atorvastatin? A research question formulated but not yet adequately tested.
Topics: Atorvastatin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Pyrroles; Research; Ticlopidine | 2003 |
A technique for type 4a coronary bifurcation lesions: initial results and 6-month clinical evaluation.
Topics: Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Angiography; Coronary Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2003 |
Spontaneous pharyngeal haemorrhage in the anticoagulated patient.
Topics: Aged; Anticoagulants; Atrial Fibrillation; Clopidogrel; Hemorrhage; Humans; Male; Pharyngeal Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2003 |
Synergistic antiplatelet effects of clopidogrel and aspirin detected with the PFA-100 in stroke patients.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Ticlopidine | 2003 |
Adherence to secondary stroke prevention strategies--results from the German Stroke Data Bank.
Topics: Administration, Oral; Anticoagulants; Aspirin; Clopidogrel; Databases as Topic; Female; Follow-Up Studies; Germany; Humans; Male; Patient Compliance; Platelet Aggregation Inhibitors; Prospective Studies; Secondary Prevention; Stroke; Ticlopidine; Time Factors | 2003 |
[Clearly superior in acute coronary syndrome. Helps aggressive platelet inhibition even after stroke?].
Topics: Acute Disease; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Syndrome; Ticlopidine; Time Factors | 2003 |
Clopidogrel and percutaneous coronary interventions.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Clopidogrel and percutaneous coronary interventions.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2003 |
Clopidogrel and percutaneous coronary interventions.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Clopidogrel and percutaneous coronary interventions.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Diabetes Mellitus; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2003 |
Clopidogrel and percutaneous coronary interventions.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
[Secondary prevention after ischemic stroke].
Topics: Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Cerebral Infarction; Clinical Trials as Topic; Clopidogrel; Evidence-Based Medicine; Fibrinolytic Agents; Humans; Risk; Secondary Prevention; Ticlopidine | 2003 |
Coronary artery bypass graft surgery in patients with recent exposure to clopidogrel and aspirin therapy.
Topics: Aspirin; Blood Component Transfusion; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement.
Topics: Adenosine Diphosphate; Aged; Angina Pectoris; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prevalence; Prosthesis Implantation; Stents; Thrombosis; Ticlopidine | 2003 |
Use of restenting should be minimized with intracoronary radiation therapy for in-stent restenosis.
Topics: Brachytherapy; Chi-Square Distribution; Clopidogrel; Coronary Restenosis; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Stents; Ticlopidine; Treatment Failure; Treatment Outcome | 2003 |
Brachytherapy for in-stent restenosis: the problem is one of commitment.
Topics: Brachytherapy; Clopidogrel; Coronary Restenosis; Humans; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine | 2003 |
Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina?
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Statistics, Nonparametric; Ticlopidine | 2003 |
Case presentations and discussions.
Topics: Age Factors; Aged; Aged, 80 and over; Cardiac Catheterization; Chest Pain; Clopidogrel; Critical Care; Electrocardiography; Emergency Service, Hospital; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Obesity, Morbid; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Risk Assessment; Sampling Studies; Severity of Illness Index; Ticlopidine; Troponin | 2003 |
The use of the X-Sizer transluminal extraction catheter as an adjunct to stenting of occluded saphenous vein grafts.
Topics: Abciximab; Aged; Antibodies, Monoclonal; Aspirin; Blood Vessel Prosthesis Implantation; Catheters, Indwelling; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Female; Graft Occlusion, Vascular; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Saphenous Vein; Stents; Ticlopidine | 2003 |
Acute coronary syndrome associated with coronary aneurysm: a case report.
Topics: Acute Disease; Aged; Aged, 80 and over; Cardiac Catheterization; Clopidogrel; Coronary Aneurysm; Coronary Disease; Diagnosis, Differential; Female; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2003 |
Clopidogrel-induced systemic inflammatory response syndrome.
Topics: Clopidogrel; Coronary Angiography; Female; Humans; Middle Aged; Platelet Aggregation Inhibitors; Stents; Systemic Inflammatory Response Syndrome; Ticlopidine | 2003 |
Antiplatelet agents. European perspective.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Europe; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2003 |
Antiplatelet drugs.
Topics: Aspirin; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Primary Prevention; Pulmonary Embolism; Thrombosis; Ticlopidine; Venous Thrombosis | 2003 |
Increased blood product use among coronary artery bypass patients prescribed preoperative aspirin and clopidogrel.
Topics: Aged; Aspirin; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Drug Therapy, Combination; Erythrocyte Transfusion; Female; Hematocrit; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Retrospective Studies; Statistics as Topic; Ticlopidine | 2003 |
Symmetry aortic connector system.
Topics: Anastomosis, Surgical; Clopidogrel; Coronary Artery Bypass; Heart-Lung Machine; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
A new twist on the chiral switch.
Topics: Clopidogrel; Patents as Topic; Stereoisomerism; Ticlopidine | 2003 |
Atorvastatin and the ability of clopidogrel to inhibit platelet aggregation.
Topics: Atorvastatin; Clopidogrel; Dose-Response Relationship, Drug; Graft Occlusion, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2003 |
Atorvastatin-clopidogrel interaction.
Topics: Aspirin; Atorvastatin; Clinical Trials as Topic; Clopidogrel; Confounding Factors, Epidemiologic; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2003 |
Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Case-Control Studies; Cell Adhesion Molecules; Chi-Square Distribution; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Coronary Thrombosis; Drug Resistance; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Monitoring, Physiologic; Phosphoproteins; Pilot Projects; Platelet Aggregation Inhibitors; Premedication; Probability; Prospective Studies; Reference Values; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Stents; Ticlopidine; Treatment Outcome | 2003 |
Clopidogrel and platelet transfusion in patients undergoing coronary artery bypass graft surgery.
Topics: Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Platelet Transfusion; Retrospective Studies; Ticlopidine | 2003 |
[Diagnosis and therapy of aneurysms of the atrial septum].
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Echocardiography; Echocardiography, Transesophageal; Heart Aneurysm; Heart Atria; Heart Septum; Humans; Incidental Findings; Intracranial Embolism; Risk; Ticlopidine | 2003 |
Clopidogrel plus long-term aspirin after femoro-popliteal stenting. The CLAFS project: 1- and 2-year results.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Angiography; Angioplasty, Balloon; Anticoagulants; Arterial Occlusive Diseases; Aspirin; Blood Flow Velocity; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; Femoral Artery; Fibrinolysis; Follow-Up Studies; Heparin, Low-Molecular-Weight; Humans; Long-Term Care; Male; Middle Aged; Popliteal Artery; Prosthesis Failure; Retrospective Studies; Secondary Prevention; Stents; Tantalum; Ticlopidine; Treatment Outcome; Ultrasonography, Doppler, Color; Ultrasonography, Doppler, Duplex | 2004 |
[Acute coronary syndrome. The second platelet inhibitor is self-paid].
Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Electrocardiography; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2003 |
Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Disease Models, Animal; Drug Interactions; Mesenteric Arteries; Mice; Mice, Mutant Strains; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thromboplastin; Thrombosis; Ticlopidine; Vena Cava, Inferior | 2003 |
Interpretation of platelet inhibition by clopidogrel and the effect of non-responders.
Topics: Clopidogrel; Humans; Models, Statistical; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2003 |
[Effects of antiaggregants on concentration of plasma cytokines in patients with acute coronary syndrome].
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Cytokines; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Angiography and interventional cardiology.
Topics: Angioplasty, Balloon, Coronary; Cardiology; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Humans; Platelet Aggregation Inhibitors; Radiography, Interventional; Stents; Ticlopidine; Treatment Outcome | 2003 |
Clopidogrel before urgent coronary artery bypass graft.
Topics: Acute Disease; Adrenergic beta-Antagonists; Aged; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Emergency Treatment; Female; Heparin; Humans; Intra-Aortic Balloon Pumping; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Switzerland; Syndrome; Ticlopidine; Treatment Outcome | 2003 |
A prospective study on ultrasound-guided compression therapy or thrombin injection for treatment of iatrogenic false aneurysms in patients receiving full-dose anti-platelet therapy.
Topics: Aged; Aged, 80 and over; Aneurysm, False; Angioplasty, Balloon, Coronary; Arteriovenous Fistula; Aspirin; Cardiac Catheterization; Catheterization, Peripheral; Clopidogrel; Female; Femoral Artery; Humans; Iatrogenic Disease; Injections, Intra-Arterial; Male; Middle Aged; Platelet Aggregation Inhibitors; Pressure; Prospective Studies; Thrombin; Ticlopidine; Transducers; Treatment Outcome; Ultrasonography, Doppler, Color | 2003 |
Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies.
Topics: Acute Disease; Aged; Atorvastatin; Clopidogrel; Comorbidity; Coronary Disease; Drug Interactions; Drug Utilization; Female; Germany; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Prospective Studies; Pyrroles; Registries; Stroke; Survival Analysis; Syndrome; Ticlopidine; Treatment Outcome | 2003 |
[Atorvastatin and clopidogrel. A possible drug interaction with clinical consequences still unknown].
Topics: Anticholesteremic Agents; Atorvastatin; Clopidogrel; Drug Interactions; Heptanoic Acids; Humans; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2003 |
Regression of intracardiac heparin-induced thrombosis after aortic root surgery.
Topics: Aged; Anticoagulants; Aortic Aneurysm, Thoracic; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Drug Therapy, Combination; Echocardiography, Transesophageal; Follow-Up Studies; Heart Diseases; Heparin, Low-Molecular-Weight; Humans; Risk Assessment; Severity of Illness Index; Thrombocytopenia; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2003 |
Subintimal angioplasty of long superficial femoral artery occlusions.
Topics: Angioplasty; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Female; Femoral Artery; Fibrinolytic Agents; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Postoperative Care; Proportional Hazards Models; Stents; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency; Warfarin | 2003 |
Clopidogrel is associated with better in-hospital and 30-day outcomes than ticlopidine after coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cause of Death; Clopidogrel; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Premedication; Product Surveillance, Postmarketing; Retrospective Studies; Stents; Survival Analysis; Ticlopidine; Treatment Outcome | 2003 |
[Long-term therapy with clopidogrel in combination with ASA significantly reduces risk of death, myocardial infarct or stroke].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Multicenter Studies as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk; Stroke; Ticlopidine | 2003 |
Qualitative platelet defect and thrombohaemorrhagic complications in a patient with polycythaemia vera. Case 10.
Topics: Aged; Aspirin; Blood Platelet Disorders; Clopidogrel; Hemorrhage; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polycythemia Vera; Thrombosis; Ticlopidine | 2003 |
Cardiology patient page. Antiplatelet therapy.
Topics: Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine | 2003 |
Intracoronary radiation to treat in-stent restenosis in six cardiac transplant patients.
Topics: Abciximab; Adult; Aged; Antibodies, Monoclonal; Arteries; Aspirin; Blood Vessel Prosthesis Implantation; Brachytherapy; California; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Female; Follow-Up Studies; Heart Transplantation; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Reoperation; Stents; Ticlopidine; Treatment Outcome | 2003 |
Clopidogrel versus ticlopidine after the placement of coronary artery stents.
Topics: Clinical Trials as Topic; Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Humans; Myocardial Revascularization; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine; Treatment Outcome | 2003 |
Ask the doctor. Almost every day I read how important it is for people with heart disease to take an aspirin. Unfortunately, I am allergic to aspirin. There must be others with the same problem. Are there viable alternatives to aspirin? It's discouraging
Topics: Aspirin; Clopidogrel; Drug Hypersensitivity; Fatty Acids, Omega-3; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
[Premedication by thienopyridine before percutaneous coronary interventions in unstable angina].
Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Premedication; Pyridines; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2003 |
[Clopidogrel and thrombopenia. A case report].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Stenosis; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Stents; Thrombocytopenia; Ticlopidine | 2003 |
Clopidogrel in acute coronary syndromes: can the cost effectiveness improve?
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk; Ticlopidine; Treatment Outcome | 2003 |
High incidence of clopidogrel-associated gastrointestinal bleeding in patients with previous peptic ulcer disease.
Topics: Aged; Aspirin; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Longitudinal Studies; Male; Peptic Ulcer; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Risk Factors; Ticlopidine | 2003 |
[Clopidogrel should be added to aspirin for at least 1 year after percutaneous coronary interventions (CREDO) while before them its loading dose can reach 600mg (ISAR-COOL)].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Electrocardiography; Fibrinolytic Agents; Follow-Up Studies; Humans; Placebos; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine; Time Factors | 2003 |
[Recurrence prophylaxis for stroke patients. Which platelet inhibitor combination protects best?].
Topics: Angiotensin II Type 1 Receptor Blockers; Aspirin; Aspirin, Dipyridamole Drug Combination; Benzimidazoles; Benzoates; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Combinations; Humans; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke; Telmisartan; Ticlopidine | 2003 |
Platelet ADP receptors contribute to the initiation of intravascular coagulation.
Topics: Adult; Animals; Blood Coagulation; Blood Platelets; Clopidogrel; Collagen; Disease Models, Animal; Disseminated Intravascular Coagulation; Factor Xa; Humans; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Reference Values; Thrombin; Thromboplastin; Thrombosis; Ticlopidine | 2004 |
[Acute myocardial infarction during pregnancy. Treatment with clopidogrel].
Topics: Adult; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Ticlopidine; Treatment Outcome | 2003 |
Improving antithrombotic treatment in patients after myocardial infarction.
Topics: Azetidines; Benzylamines; Clopidogrel; Fibrinolytic Agents; Glycine; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome; Warfarin | 2003 |
Epidemiology of acute myocardial infarction in the Italian CCU network: the BLITZ study.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Care Units; Emergency Medical Services; Female; Fibrinolytic Agents; Follow-Up Studies; Guideline Adherence; Heparin; Hospitalization; Humans; Italy; Length of Stay; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prospective Studies; Thrombolytic Therapy; Ticlopidine; Time Factors | 2003 |
Urgent or emergent coronary revascularization using bilateral internal thoracic artery after previous clopidogrel antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Transfusion; Chest Tubes; Clopidogrel; Coronary Artery Bypass; Emergencies; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Retrospective Studies; Ticlopidine | 2003 |
Atorvastatin and clopidogrel.
Topics: Atorvastatin; Clopidogrel; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2003 |
Elective coronary angiography and percutaneous coronary intervention during uninterrupted warfarin therapy.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Atrial Fibrillation; Cardiac Catheterization; Cerebrovascular Disorders; Clopidogrel; Coronary Angiography; Coronary Disease; Equipment Design; Feasibility Studies; Female; Follow-Up Studies; Heart Failure; Heart Septal Defects, Atrial; Heart Valve Diseases; Humans; International Normalized Ratio; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine; Treatment Outcome; Venous Thrombosis; Warfarin | 2003 |
Platelet inhibition strategies in percutaneous coronary intervention: competition or coopetition?
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Combined Modality Therapy; Drug Administration Schedule; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Tirofiban; Tyrosine | 2003 |
Clopidogrel-induced membranous nephropathy.
Topics: Aged; Clopidogrel; Glomerulonephritis, Membranous; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
[Outpatient primary stent-angioplasty in symptomatic internal carotid artery stenoses].
Topics: Aged; Angiography; Angioplasty, Balloon; Anticoagulants; Aspirin; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Embolism; Female; Fibrinolytic Agents; Follow-Up Studies; Heparin; Humans; Male; Middle Aged; Outpatients; Patient Selection; Platelet Aggregation Inhibitors; Prostheses and Implants; Risk Factors; Stents; Ticlopidine; Time Factors | 2003 |
Potent mechanism-based inhibition of human CYP2B6 by clopidogrel and ticlopidine.
Topics: Aryl Hydrocarbon Hydroxylases; Bupropion; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxylation; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Complete lysis of left ventricular giant thrombus with fibrinolytic therapy in clopidogrel resistant patient.
Topics: Clopidogrel; Drug Resistance; Electrocardiography; Female; Humans; Middle Aged; Thrombolytic Therapy; Thrombosis; Ticlopidine; Treatment Outcome; Ventricular Dysfunction, Left | 2003 |
[PRoFESS study presented. Change in secondary prevention].
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Aspirin, Dipyridamole Drug Combination; Benzimidazoles; Benzoates; Clopidogrel; Controlled Clinical Trials as Topic; Dipyridamole; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Multicenter Studies as Topic; Placebos; Platelet Aggregation Inhibitors; Recurrence; Risk; Stroke; Telmisartan; Ticlopidine; Time Factors | 2003 |
[Dual platelet inhibition with clopidogrel and ASS. Who profits from the combination?].
Topics: Acute Disease; Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Cyclooxygenase Inhibitors; Drug Synergism; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Stents; Stroke; Syndrome; Thrombosis; Ticlopidine | 2003 |
[Long-term effect of clopidogrel do exist--but hardly worth the costs].
Topics: Clopidogrel; Coronary Disease; Drug Costs; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
[The CREDO study has obvious shortages. More belief, less knowledge].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2003 |
[Sudden edema and pain in the knee].
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Edema; Hemorrhage; Humans; Knee Joint; Male; Pain; Platelet Aggregation Inhibitors; Radiography; Ticlopidine | 2003 |
The plunger, fine tuned.
Topics: Angina Pectoris; Cardiopulmonary Resuscitation; Clopidogrel; Drug Therapy, Combination; Emergency Treatment; Heart Arrest; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ticlopidine; Treatment Outcome | 2003 |
The antiaggregating activity of clopidogrel is not affected by N-acetyl L-cysteine.
Topics: Acetylcysteine; Adenosine Diphosphate; Animals; Blood Platelets; Cells, Cultured; Clopidogrel; Drug Interactions; Female; Humans; Male; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2003 |
Cost-effectiveness of newer antiplatelet drugs.
Topics: Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Red vs white thrombi: treating the right clot is crucial.
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2003 |
Safety and efficacy of the Perclose suture-mediated closure device following carotid artery stenting under clopidogrel platelet blockade.
Topics: Aged; Angioplasty; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Female; Femoral Artery; Follow-Up Studies; Hemostasis, Surgical; Humans; Male; Platelet Aggregation Inhibitors; Stents; Suture Techniques; Ticlopidine; Time Factors | 2004 |
Regression of collateral function after recanalization of chronic total coronary occlusions: a serial assessment by intracoronary pressure and Doppler recordings.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Collateral Circulation; Combined Modality Therapy; Coronary Angiography; Coronary Circulation; Coronary Disease; Female; Follow-Up Studies; Heparin; Humans; Laser-Doppler Flowmetry; Male; Middle Aged; Nitroglycerin; Pressure; Recurrence; Stroke Volume; Ticlopidine; Ultrasonography | 2003 |
Akt activation in platelets depends on Gi signaling pathways.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; In Vitro Techniques; Mice; Mice, Knockout; Oligopeptides; Peptide Fragments; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thrombin; Ticlopidine | 2004 |
Platelet function under aspirin, clopidogrel, and both after ischemic stroke: a case-crossover study.
Topics: Antigens, CD; Aspirin; Biomarkers; Blood Platelets; Brain Ischemia; Clopidogrel; Cross-Over Studies; Humans; P-Selectin; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Stroke; Tetraspanin 30; Ticlopidine | 2003 |
By the way, doctor. A new television ad says I should ask my doctor about Plavix, a drug that reduces the risk of heart attack and stroke. I'm 65 years old and healthy. Should I be taking Plavix preventively?
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Female; Health Status; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Reduced thrombus cohesion in an ex vivo human model of arterial thrombosis induced by clopidogrel treatment: kinetics of the effect and influence of single and double loading-dose regimens.
Topics: Adult; Arterial Occlusive Diseases; Clopidogrel; Confidence Intervals; Drug Administration Schedule; Humans; In Vitro Techniques; Kinetics; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2003 |
Serum sickness-like reaction associated with clopidogrel.
Topics: Acute Disease; Clopidogrel; Coronary Disease; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Serum Sickness; Syndrome; Ticlopidine | 2003 |
Clopidogrel-associated acute arthritis.
Topics: Acute Disease; Arthritis; Clopidogrel; Diagnosis, Differential; Female; Humans; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesis.
Topics: Adult; Aspirin; Blood Platelets; Cells, Cultured; Clopidogrel; Epoprostenol; Humans; Male; Middle Aged; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Ticlopidine | 2004 |
Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Alprostadil; Calcium; Calcium Signaling; Clopidogrel; Cytoplasm; Dose-Response Relationship, Drug; Drug Synergism; Humans; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors | 2004 |
Guglielmi detachable coils embolization of a penetrating vertebral artery injury: a case report.
Topics: Angiography, Digital Subtraction; Cerebral Angiography; Cervical Atlas; Clopidogrel; Combined Modality Therapy; Embolization, Therapeutic; Facial Injuries; Foreign Bodies; Fractures, Bone; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Vertebral Artery; Wounds, Penetrating | 2003 |
Comparison of turbidimetric aggregation and in vitro bleeding time (PFA-100) for monitoring the platelet inhibitory profile of antiplatelet agents in patients undergoing stent implantation.
Topics: Abciximab; Adenosine Diphosphate; Aged; Angina Pectoris; Antibodies, Monoclonal; Aspirin; Bleeding Time; Clopidogrel; Collagen; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine; Time Factors | 2003 |
Thienopyridine-linked thrombotic microangiopathy: association with endothelial cell apoptosis and activation of MAP kinase signalling cascades.
Topics: Adult; Aged; Apoptosis; Cells, Cultured; Clopidogrel; Endothelium, Vascular; Epithelial Cells; Female; Humans; Male; MAP Kinase Signaling System; Microcirculation; Middle Aged; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2004 |
Fatal toxic bone marrow failure associated with clopidogrel.
Topics: Adult; Antiphospholipid Syndrome; Bone Marrow Diseases; Clopidogrel; Fatal Outcome; Female; Humans; Pancytopenia; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
Clopidogrel-associated TTP: an update of pharmacovigilance efforts conducted by independent researchers, pharmaceutical suppliers, and the Food and Drug Administration.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Causality; Clopidogrel; Female; Humans; Male; Middle Aged; Plasma Exchange; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Prognosis; Purpura, Thrombotic Thrombocytopenic; Recurrence; Survival Rate; Ticlopidine; Time Factors; United States; United States Food and Drug Administration | 2004 |
Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel.
Topics: Animals; Carotid Artery Injuries; Carotid Artery Thrombosis; Clopidogrel; Drug Synergism; Electric Injuries; Male; Mice; Mice, Inbred BALB C; Platelet Aggregation; Platelet Aggregation Inhibitors; Polysaccharides; Thrombosis; Ticlopidine | 2004 |
Off-pump coronary artery bypass grafting attenuates postoperative bleeding associated with preoperative clopidogrel administration.
Topics: Case-Control Studies; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Ticlopidine | 2003 |
A feasibility study of the safety and efficacy of a combined clopidogrel and aspirin regimen following off-pump coronary artery bypass grafting.
Topics: Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Feasibility Studies; Female; Follow-Up Studies; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Stroke; Ticlopidine; Venous Thrombosis | 2003 |
Risk of colonoscopic polypectomy bleeding with anticoagulants and antiplatelet agents: analysis of 1657 cases.
Topics: Aged; Anticoagulants; Clopidogrel; Colonic Polyps; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; International Normalized Ratio; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Ticlopidine; Warfarin | 2004 |
Aspirin for cardiovascular disease prevention.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2004 |
Antiplatelet therapy for ischemic heart disease.
Topics: Abciximab; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2004 |
[Criteria for Plavix (clopidogrel) administration].
Topics: Clopidogrel; Denmark; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2003 |
Influence of glucose concentration on the effects of aspirin, ticlopidine and clopidogrel on platelet function and platelet-subendothelium interaction.
Topics: Adult; Aspirin; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Endothelium, Vascular; Glucose; Humans; Male; Middle Aged; Platelet Aggregation; Ticlopidine | 2004 |
Catheter based intracoronary brachytherapy leads to increased platelet activation.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Blood Platelets; Brachytherapy; Clopidogrel; Coronary Restenosis; Equipment Failure; Female; Flow Cytometry; Heparin; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2004 |
Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events.
Topics: Aged; Arteriosclerosis; Aspirin; Brain Ischemia; Clopidogrel; Databases, Factual; Female; Hospitalization; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Randomized Controlled Trials as Topic; Risk; Secondary Prevention; Stroke; Survival Rate; Ticlopidine; Treatment Outcome | 2004 |
[Must platelet aggregation inhibitors be discontinued before surgery?].
Topics: Angiography; Aspirin; Blood Loss, Surgical; Clopidogrel; Humans; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Risk Factors; Thromboembolism; Ticlopidine | 2004 |
Editorial comment--an approach to the estimation of the risk of TTP during clopidogrel therapy.
Topics: Clopidogrel; Drug Utilization; Humans; Incidence; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Purpura, Thrombotic Thrombocytopenic; Risk Assessment; Ticlopidine; United States | 2004 |
Clopidogrel induced urticarial rash in a patient with left main stem percutaneous coronary intervention: management issues.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Drug Eruptions; Female; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Urticaria | 2004 |
Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization.
Topics: Adult; Aged; Aged, 80 and over; Cardiac Catheterization; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Ticlopidine | 2004 |
Increased platelet CD63 and P-selectin expression persist in atherosclerotic ischemic stroke.
Topics: Adenosine Diphosphate; Aged; Anticoagulants; Antigens, CD; Aspirin; Blood Platelets; Brain Ischemia; Clopidogrel; Collagen; Female; Flow Cytometry; Heparin; Humans; Intracranial Arteriosclerosis; Lipids; Male; Middle Aged; P-Selectin; Patient Selection; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Stroke; Tetraspanin 30; Ticlopidine; Time Factors | 2004 |
Proximal deep venous thrombosis occurring after sudden clopidogrel suspension.
Topics: Aged; Atrial Fibrillation; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Prognosis; Substance Withdrawal Syndrome; Ticlopidine; Urticaria; Venous Thrombosis; Withholding Treatment | 2004 |
Percutaneous coronary intervention in a patient with immune thrombocytopenia purpura.
Topics: Aged; Angioplasty, Balloon; Aspirin; Clopidogrel; Coronary Angiography; Coronary Stenosis; Eptifibatide; Humans; Male; Peptides; Platelet Aggregation Inhibitors; Purpura, Thrombocytopenic, Idiopathic; Stents; Ticlopidine | 2004 |
Lack of adverse clopidogrel-atorvastatin clinical interaction.
Topics: Atorvastatin; Clopidogrel; Coronary Disease; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Pyrroles; Research Design; Ticlopidine | 2004 |
[Interaction of statins with clopidogrel].
Topics: Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Biotransformation; Cause of Death; Clinical Trials as Topic; Clopidogrel; Coronary Restenosis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Infarction; Platelet Aggregation Inhibitors; Prodrugs; Rhabdomyolysis; Risk Factors; Stents; Stroke; Survival Analysis; Ticlopidine | 2004 |
When guidelines collide...
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stents; Ticlopidine; Warfarin | 2004 |
Safety and efficacy of aspirin, clopidogrel, and warfarin after coronary stent placement in patients with an indication for anticoagulation.
Topics: Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Warfarin | 2004 |
[Efficacy and safety of treatment of acute ischemic stroke with glycoprotein IIb/IIIa receptor blocker in routine clinical practice].
Topics: Adult; Aged; Anticoagulants; Aspirin; Brain; Brain Ischemia; Carotid Arteries; Clopidogrel; Drug Therapy, Combination; Echocardiography, Transesophageal; Eptifibatide; Female; Heparin; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Retrospective Studies; Stroke; Ticlopidine; Tirofiban; Tomography, X-Ray Computed; Tyrosine; Ultrasonography, Doppler | 2004 |
Analysis of purity in 19 drug product tablets containing clopidogrel: 18 copies versus the original brand.
Topics: Chromatography, High Pressure Liquid; Clopidogrel; Drug Contamination; Pharmaceutical Preparations; Tablets; Ticlopidine | 2004 |
Massive nasal bleeding and hemodynamic instability associated with clopidogrel.
Topics: Clopidogrel; Deamino Arginine Vasopressin; Epistaxis; Female; Hemodynamics; Hemostatics; Humans; Ischemic Attack, Transient; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Creatine Kinase; Creatine Kinase, MB Form; Drug Resistance; Female; Humans; Incidence; Isoenzymes; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Period; Sex Factors; Ticlopidine; Troponin I | 2004 |
Do statins really interfere with clopidogrel-induced platelet function?
Topics: Blood Platelets; Clopidogrel; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; P-Selectin; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Are we making efficient use of clopidogrel?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine | 2004 |
Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
If there's smoke, is there fire?
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Endpoint Determination; Humans; Intracranial Embolism; Platelet Aggregation Inhibitors; Postoperative Complications; Randomized Controlled Trials as Topic; Research Design; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2004 |
Guidelines on the management of secondary prophylaxis of vascular events in stable patients in primary care.
Topics: Acute Disease; Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Bypass; Dipyridamole; Endarterectomy, Carotid; Humans; Life Style; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stents; Ticlopidine; Treatment Outcome | 2004 |
For how long should treatment with clopidogrel be continued after coronary stent implantation?
Topics: Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis Implantation; Clopidogrel; Combined Modality Therapy; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine; Time Factors | 2004 |
Subcutaneous enoxaparin with early invasive strategy in patients with acute coronary syndromes.
Topics: Analysis of Variance; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Cardiac Catheterization; Clopidogrel; Drug Administration Schedule; Enoxaparin; Hemorrhage; Humans; Injections, Subcutaneous; Logistic Models; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Retrospective Studies; Risk Factors; Ticlopidine | 2004 |
Late stent thrombosis (> 1 year) following clopidogrel withdrawal after brachytherapy treatment: need to assess aspirin resistance?
Topics: Adult; Angioplasty, Balloon, Coronary; Aspirin; Blood Vessel Prosthesis Implantation; Brachytherapy; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Drug Resistance; Graft Occlusion, Vascular; Humans; Male; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors | 2004 |
Resistance to antiplatelet drugs: is it real or relevant?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Vessel Prosthesis Implantation; Brachytherapy; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug Resistance; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors | 2004 |
[Even when walking yet does not cause any pain, peripheral arterial occlusive disease costs life years].
Topics: Arterial Occlusive Diseases; Clinical Trials as Topic; Clopidogrel; Diabetes Complications; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Walking | 2003 |
2 drugs team up for protection. Old standby joins relative newcomer to battle heart disease.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2003 |
"Super aspirin" cuts risks after multiple cardiac events.
Topics: Aspirin; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2004 |
Detection of acutely impaired microvascular reperfusion after infarct angioplasty with magnetic resonance imaging.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Circulation; Female; Heart Ventricles; Heparin; Humans; Immunoglobulin Fab Fragments; Magnetic Resonance Imaging; Male; Microcirculation; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Prospective Studies; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine; Ventricular Function, Left | 2004 |
Long-term clopidogrel therapy after percutaneous coronary intervention in PCI-CURE and CREDO: the "Emperor's New Clothes" revisited.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Humans; Long-Term Care; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Hepatotoxicity induced by clopidogrel.
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Paclitaxel-eluting coronary stents.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Pyridines; Stents; Thrombosis; Ticlopidine | 2004 |
Antiplatelet therapy for ischemic heart disease.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Basilar artery to bilateral posterior cerebral artery 'Y stenting' for endovascular reconstruction of wide-necked basilar apex aneurysms: report of three cases.
Topics: Adult; Aged; Aspirin; Cerebral Angiography; Clopidogrel; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Posterior Cerebral Artery; Stents; Ticlopidine; Treatment Outcome | 2004 |
Platelet inhibition limits TGF-beta overexpression and matrix expansion after induction of anti-thy1 glomerulonephritis.
Topics: Animals; Blood Platelets; Clopidogrel; Glomerulonephritis; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thy-1 Antigens; Ticlopidine; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose be weight adjusted?
Topics: Aged; Blood Vessel Prosthesis Implantation; Body Mass Index; Body Weight; Clopidogrel; Coronary Stenosis; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Spain; Stents; Ticlopidine; Treatment Outcome; Weights and Measures | 2004 |
Clopidogrel dosing in overweight patients: does one size fit all?
Topics: Blood Vessel Prosthesis Implantation; Body Mass Index; Body Weight; Clopidogrel; Coronary Stenosis; Dose-Response Relationship, Drug; Humans; Obesity; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2004 |
By the way, doctor. I'm 74 and in good health with no apparent heart problems. Because I am allergic to aspirin, it has been suggested that I take Plavix. Your thoughts?
Topics: Aged; Aspirin; Clopidogrel; Drug Hypersensitivity; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Serial changes in platelet activation in patients after ischemic stroke: role of pharmacodynamic modulation.
Topics: Aged; Anticoagulants; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Stroke; Ticlopidine; Warfarin | 2004 |
Clopidogrel-atorvastatin interaction.
Topics: Atorvastatin; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Therapy, Combination; Heptanoic Acids; Humans; Platelet Aggregation Inhibitors; Pravastatin; Prodrugs; Pyrroles; Ticlopidine | 2004 |
Clopidogrel-induced thrombotic thrombocytopenic purpura-hemolytic uremic syndrome after coronary artery stenting.
Topics: Clopidogrel; Coronary Disease; Hemolytic-Uremic Syndrome; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Stents; Ticlopidine | 2004 |
PlA polymorphism and platelet reactivity following clopidogrel loading dose in patients undergoing coronary stent implantation.
Topics: Abciximab; Adenosine Diphosphate; Aged; Amino Acid Substitution; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Heterozygote; Homozygote; Humans; Immunoglobulin Fab Fragments; Integrin beta3; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Stents; Ticlopidine; Treatment Outcome | 2004 |
Clopidogrel versus aspirin for secondary prophylaxis of vascular events: a cost-effectiveness analysis.
Topics: Aspirin; Clopidogrel; Cost-Benefit Analysis; Fibrinolytic Agents; Humans; Markov Chains; Middle Aged; Platelet Aggregation Inhibitors; Sensitivity and Specificity; Ticlopidine; Vascular Diseases | 2004 |
Aspirin or clopidogrel for secondary prevention of cardiovascular events: is there a winner?
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction.
Topics: Adenosine Diphosphate; Aged; Aspirin; Biotransformation; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Epinephrine; Eptifibatide; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Prospective Studies; Purinergic P2 Receptor Antagonists; Recurrence; Risk; Smoking; Stents; Ticlopidine; Treatment Outcome | 2004 |
Long-term management of patients with unstable angina and non-ST-elevation MI.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Evidence-Based Medicine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine; Treatment Outcome | 2004 |
Hypersensitivity skin rash: an adverse drug reaction to clopidogrel loading dose.
Topics: Clopidogrel; Drug Eruptions; Female; Humans; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Different treatments and outcomes of consecutive patients with non-ST-elevation myocardial infarction depending on initial electrocardiographic changes (results of the Acute Coronary Syndromes [ACOS] Registry).
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Coronary Disease; Coronary Vessels; Drug Utilization; Electrocardiography; Female; Germany; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Multivariate Analysis; Myocardial Infarction; Outcome and Process Assessment, Health Care; Platelet Aggregation Inhibitors; Recurrence; Registries; Stroke Volume; Ticlopidine; Ventricular Dysfunction, Left | 2004 |
Effect of clopidogrel on tissue-plasminogen activator-induced in vitro thrombolysis of feline whole blood thrombi.
Topics: Animals; Cat Diseases; Cats; Clopidogrel; Fibrinolytic Agents; In Vitro Techniques; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine; Time Factors; Tissue Plasminogen Activator | 2004 |
Impact of clopidogrel in coronary artery bypass grafting.
Topics: Aged; Chest Tubes; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Female; Hemostasis, Surgical; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Reoperation; Ticlopidine; Treatment Outcome | 2004 |
Clopidogrel before coronary artery surgery: bleeding or no bleeding?
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Ticlopidine | 2004 |
807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Collagen; Coronary Disease; Female; Humans; Integrin alpha2; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Thrombosis; Ticlopidine | 2004 |
[Antithrombotic treatment of acute coronary syndrome].
Topics: Anticoagulants; Aspirin; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 2004 |
The effect of clopidogrel on apoptosis--an in vivo study.
Topics: Adult; Aged; Apoptosis; Cells, Cultured; Clopidogrel; Coronary Artery Disease; DNA; DNA Fragmentation; Electrophoresis, Agar Gel; Female; Humans; Leukocyte Count; Lymphocytes; Male; Middle Aged; Ticlopidine | 2004 |
Clopidogrel-associated autoimmune thrombocytopenic purpura.
Topics: Clopidogrel; Glucocorticoids; Humans; Male; Methylprednisolone; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Transfusion; Purpura, Thrombocytopenic, Idiopathic; Stents; Ticlopidine | 2004 |
Clopidogrel resistance: a new chapter in a fast-moving story.
Topics: Angioplasty; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Eptifibatide; Heparin; Humans; Peptides; Platelet Aggregation Inhibitors; Stents; Thromboxane A2; Ticlopidine; Treatment Outcome | 2004 |
Clopidogrel resistance marks recurrent risks.
Topics: Aged; Bibliometrics; Cardiology; Clopidogrel; Cohort Studies; Coronary Restenosis; Drug Resistance; Estrogen Receptor alpha; Female; Folic Acid; Genetic Predisposition to Disease; Heart Diseases; Humans; Male; Mass Screening; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Platelet Aggregation Inhibitors; Predictive Value of Tests; Recurrence; Risk; Stents; Ticlopidine; Vitamin B 12; Vitamin B 6 | 2004 |
Antifibrinolytics may be cost saving among recent recipients of combined acetylsalicylic acid and clopidogrel who undergo coronary artery bypass graft surgery.
Topics: Antifibrinolytic Agents; Aspirin; Clopidogrel; Coronary Artery Bypass; Cost-Benefit Analysis; Drug Costs; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2004 |
[New antiplatelet agents (platelet receptor blockers): has aspirin come out of place?].
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Thrombophilia; Ticlopidine; Treatment Outcome | 2004 |
Diminishing returns...and too many choices...the saga of pharmacologic therapy to reduce the complications of percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Biomarkers; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Disease; Creatine Kinase; Creatine Kinase, MB Form; Humans; Isoenzymes; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine; Troponin I | 2004 |
[What should one pay attention to during surgery shortly after brachytherapy with coated stents?].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Brachytherapy; Clopidogrel; Contraindications; Coronary Thrombosis; Elective Surgical Procedures; Emergency Treatment; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine; Time Factors | 2004 |
Building evidence for early initiation of clopidogrel loading in non-ST-segment elevation acute coronary syndromes: going past the American College of Cardiology/American Heart Association guidelines.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Emergency Service, Hospital; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2004 |
[Plavix--medicine of the year 2003].
Topics: Awards and Prizes; Clopidogrel; Humans; Hungary; Platelet Aggregation Inhibitors; Societies, Pharmaceutical; Ticlopidine | 2004 |
Clopidogrel "resistance".
Topics: Clinical Trials as Topic; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Protein Isoforms; Thrombosis; Ticlopidine; Time Factors | 2004 |
Pharmacokinetics of clopidogrel after administration of a high loading dose.
Topics: Administration, Oral; Adult; Area Under Curve; Blood Platelets; Carbon; Chromatography, Liquid; Clopidogrel; Dose-Response Relationship, Drug; Edetic Acid; Female; Humans; Linear Models; Male; Mass Spectrometry; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sulfhydryl Compounds; Thrombosis; Ticlopidine; Time Factors | 2004 |
Effect of clopidogrel pretreatment on periprocedural rise in C-reactive protein after percutaneous coronary intervention.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; C-Reactive Protein; Case-Control Studies; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Disease; Coronary Restenosis; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Reference Values; Risk Assessment; Severity of Illness Index; Ticlopidine; Treatment Outcome | 2004 |
Multivessel distal sutureless off-pump coronary artery bypass grafting procedure using magnetic connectors.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Restenosis; Coronary Stenosis; Equipment Design; Humans; Internal Mammary-Coronary Artery Anastomosis; Magnetics; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine | 2004 |
[Interaction between clopidogrel and statins?].
Topics: Anticholesteremic Agents; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Long-term clopidogrel therapy in the drug-eluting stent era: beyond CREDO and PCI-CURE.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2004 |
Economics of sirolimus-eluting stents: drug-eluting stents have really arrived.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Cost-Benefit Analysis; Humans; Myocardial Revascularization; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Sirolimus; Stents; Ticlopidine | 2004 |
Neutropenia due to clopidogrel in a patient with end-stage renal disease.
Topics: Adult; Clopidogrel; Humans; Kidney Failure, Chronic; Male; Neutropenia; Platelet Aggregation Inhibitors; Renal Dialysis; Ticlopidine | 2004 |
Acquired haemophilia A may be associated with clopidogrel.
Topics: Aged; Clopidogrel; Female; Hemophilia A; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
A critical appraisal of the CURE trial: role of clopidogrel in non-ST-segment elevation acute coronary syndromes.
Topics: Aspirin; Clopidogrel; Confidence Intervals; Humans; Myocardial Infarction; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2004 |
Clinical significance of the atorvastatin-clopidogrel drug-drug interaction.
Topics: Atorvastatin; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Sample Size; Ticlopidine | 2004 |
Potential statin-clopidogrel interaction requires more study.
Topics: Atorvastatin; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2004 |
Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival.
Topics: Animals; Animals, Genetically Modified; Antigens, CD; Aspirin; Clopidogrel; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Membrane Cofactor Protein; Membrane Glycoproteins; Papio anubis; Platelet Aggregation; Platelet Aggregation Inhibitors; Swine; Ticlopidine; Time Factors; Transplantation, Heterologous | 2004 |
Transcriptional down-regulation of the platelet ADP receptor P2Y(12) and clusterin in patients with systemic lupus erythematosus.
Topics: Adolescent; Adult; Blood Platelets; Blotting, Western; Clopidogrel; Clusterin; Dimerization; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Female; Glycoproteins; Humans; Linear Models; Lupus Erythematosus, Systemic; Male; Membrane Proteins; Middle Aged; Molecular Chaperones; Platelet Activation; Platelet Aggregation; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Ticlopidine | 2004 |
There is no evidence that the benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events.
Topics: Arteriosclerosis; Aspirin; Brain Ischemia; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prognosis; Risk; Ticlopidine | 2004 |
Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome associated with clopidogrel: report of two new cases.
Topics: Adult; Aged; Angina Pectoris; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Hemolytic-Uremic Syndrome; Humans; Male; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2004 |
Platelet function predicts myocardial damage in patients with acute myocardial infarction.
Topics: Abciximab; Adenosine Diphosphate; Aged; Antibodies, Monoclonal; Anticoagulants; Aspirin; Cardiovascular Agents; Clopidogrel; Collagen; Comorbidity; Eptifibatide; Female; Humans; Immunoglobulin Fab Fragments; Leukocyte Count; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Myocardium; Necrosis; Peptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Ticlopidine; Tirofiban; Tyrosine; von Willebrand Factor | 2004 |
Combined aspirin and clopidogrel in cataract surgical patients: a new risk factor for ocular haemorrhage?
Topics: Aged; Aspirin; Cataract Extraction; Clopidogrel; Drug Therapy, Combination; Eye Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2004 |
[Cardiovascular pharmacology].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Fatty Acids, Omega-3; Fibrinolytic Agents; Graft Occlusion, Vascular; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2004 |
[Cost effectiveness of clopidogrel in acute coronary syndromes without ST-elevation (unstable angina, non-Q AMI)].
Topics: Acute Disease; Angina, Unstable; Canada; Cardiology; Clopidogrel; Congresses as Topic; Cost-Benefit Analysis; France; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Societies, Medical; Sweden; Ticlopidine; United Kingdom; United States | 2004 |
Perioperative hemorrhage and combined clopidogrel and aspirin therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Combinations; Endarterectomy, Carotid; Female; Goiter, Nodular; Hemorrhage; Humans; Intraoperative Complications; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Thyroidectomy; Ticlopidine; Tomography, X-Ray Computed | 2004 |
Antiplatelet and anticoagulant prophylaxis and postoperative blood loss in cardiac surgery.
Topics: Anticoagulants; Cardiac Surgical Procedures; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Premedication; Ticlopidine | 2004 |
Antiplatelet agents and bleeding after cardiac surgery.
Topics: Anticoagulants; Cardiac Surgical Procedures; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Premedication; Ticlopidine | 2004 |
[Guidelines: acute coronary syndrome (ACS)].
Topics: Acute Disease; Angina, Unstable; Clinical Trials as Topic; Clopidogrel; Coronary Angiography; Electrocardiography; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Syndrome; Ticlopidine | 2004 |
Comparison of long-term usefulness of clopidogrel therapy after the first percutaneous coronary intervention or coronary artery bypass grafting versus that after the second or repeat intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Reoperation; Risk Reduction Behavior; Ticlopidine | 2004 |
Elevations in troponin I after percutaneous coronary interventions are associated with abnormal tissue-level perfusion in high-risk patients with non-ST-segment-elevation acute coronary syndromes.
Topics: Abciximab; Acute Disease; Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Biomarkers; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Coronary Circulation; Electrocardiography; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion Injury; Platelet Aggregation Inhibitors; Prospective Studies; Risk; Ticlopidine; Tirofiban; Troponin I; Tyrosine; Ultrasonography | 2004 |
[Urgent or emergent coronary revascularization using bilateral internal thoracic artery after previous clopidogrel antiplatelet therapy].
Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Data Interpretation, Statistical; Emergencies; Female; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Respiration, Artificial; Retrospective Studies; Thoracic Arteries; Ticlopidine | 2004 |
[Secondary prevention of TIA and stroke. How much must thrombocytes not be inhibited?].
Topics: Aspirin; Cerebral Infarction; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Ischemic Attack, Transient; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk; Secondary Prevention; Ticlopidine | 2004 |
[For which patient ASS, clopidogrel or dipyridamole? (interview by Dr. Med. Dirk Einecke)].
Topics: Aspirin; Cerebral Infarction; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 2004 |
Clopidogrel (Plavix) and cardiac surgical patients: implications for platelet function monitoring and postoperative bleeding.
Topics: Adenosine; Adenosine Diphosphate; Aged; Aged, 80 and over; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Postoperative Hemorrhage; Purinergic P2 Receptor Antagonists; Retrospective Studies; Thrombelastography; Ticlopidine; Time Factors | 2004 |
[How does it work? Coronary stent implantation].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2004 |
Effects of a novel platelet nitric oxide donor (LA816), aspirin, clopidogrel, and combined therapy in inhibiting flow- and lesion-dependent thrombosis in the porcine ex vivo model.
Topics: Adenosine Diphosphate; Amino Acids; Animals; Aspirin; Benzoates; Blood Pressure; Clopidogrel; Collagen; Cyclooxygenase Inhibitors; Drug Evaluation; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; Guanylate Cyclase; Heart Rate; Hemorheology; Imidazoles; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Quinoxalines; Random Allocation; Receptors, Purinergic P2Y12; rhoA GTP-Binding Protein; Sus scrofa; Thrombosis; Ticlopidine | 2004 |
Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
Topics: Administration, Oral; Aspirin; Clopidogrel; Coronary Thrombosis; Evidence-Based Medicine; Humans; Myocardial Revascularization; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Risk Factors; Thromboembolism; Ticlopidine; Treatment Outcome | 2004 |
Efficacy of clopidogrel in the treatment of post-ASD closure migraines.
Topics: Balloon Occlusion; Clopidogrel; Epilepsy; Heart Septal Defects, Atrial; Humans; Migraine Disorders; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Clopidogrel in coronary artery surgery.
Topics: Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Ticlopidine | 2004 |
[Peridural injections during acetylsalicylic acid and clopidogrel therapy?].
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Injections, Epidural; Intervertebral Disc Displacement; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2004 |
Late coronary thrombosis after drug-eluting stent: stent vs patient-driven prescription of aspirin-clopidogrel combination.
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Middle Aged; Practice Guidelines as Topic; Stents; Ticlopidine; Time Factors | 2004 |
Clopidogrel loading dose pre-PCI: how high?
Topics: Clopidogrel; Dose-Response Relationship, Drug; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2004 |
Simultaneous kissing stents (SKS) technique for treating bifurcation lesions in medium-to-large size coronary arteries.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Biomarkers; Blood Vessel Prosthesis Implantation; Clopidogrel; Coated Materials, Biocompatible; Combined Modality Therapy; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Creatine Kinase; Creatine Kinase, MB Form; Disease-Free Survival; Equipment Design; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Isoenzymes; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; New York; Platelet Aggregation Inhibitors; Postoperative Complications; Severity of Illness Index; Stents; Ticlopidine; Treatment Outcome; Troponin I | 2004 |
[Clopidogrel protection is not increased further by ASS!].
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Ischemic Attack, Transient; Middle Aged; Placebos; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Stroke; Ticlopidine | 2004 |
[Clopidogrel as basic therapy in high-risk stroke patients].
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Hemorrhage; Humans; Life Style; Meta-Analysis as Topic; Multicenter Studies as Topic; Placebos; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Ticlopidine; Time Factors | 2004 |
Coronary spasm in a 59-yr-old woman with hyperventilation.
Topics: Alkalosis, Respiratory; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antihypertensive Agents; Aspirin; Cardiac Catheterization; Clopidogrel; Coronary Artery Disease; Coronary Vasospasm; Diagnosis, Differential; Diltiazem; Electrocardiography; Female; Heparin; Humans; Hyperventilation; Hyponatremia; Middle Aged; Platelet Aggregation Inhibitors; Schizophrenia; Ticlopidine; Water Intoxication | 2004 |
Should the MATCH results be extrapolated to all stroke patients and affect ongoing trials evaluating clopidogrel plus aspirin?
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2004 |
Progressive cervicocranial arteriopathy with dilatations and stenoses: case report.
Topics: Adult; Arterial Occlusive Diseases; Aspirin; Basilar Artery; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral Angiography; Clopidogrel; Female; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Subarachnoid Hemorrhage; Ticlopidine | 2004 |
Absence of interaction between atorvastatin or other statins and clopidogrel: results from the interaction study.
Topics: Aged; Anticholesteremic Agents; Atorvastatin; Blood Platelets; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Stenosis; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Pyrroles; Stents; Ticlopidine | 2004 |
[Cooperation between university-industry].
Topics: Awards and Prizes; Berlin; Biomedical Research; Clopidogrel; Drug Industry; Germany; Humans; Interinstitutional Relations; Platelet Aggregation Inhibitors; Ticlopidine; Universities | 2004 |
[Current pharmacological principles to inhibit platelet function and their clinical implications. Focus on clopidogrel].
Topics: Aspirin; Clopidogrel; Embolism, Cholesterol; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2004 |
[Antiplatelet strategies in the acute and chronic therapy of cardiovascular disease].
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Humans; Long-Term Care; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2004 |
[Antiplatelet therapy in patients with peripheral arterial disease (PAD)].
Topics: Arterial Occlusive Diseases; Aspirin; Cause of Death; Cerebral Infarction; Clopidogrel; Coronary Artery Disease; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Survival Rate; Ticlopidine | 2004 |
[Secondary prevention of stroke with antiplatelet drugs].
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Activation; Platelet Aggregation Inhibitors; Risk; Secondary Prevention; Stroke; Survival Rate; Ticlopidine | 2004 |
[After coronary stenting course of ticlopidine (1 month) compared with that of clopidogrel was associated with significantly lower cardiovascular mortality during 28 moths follow up].
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Data Interpretation, Statistical; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine; Time Factors | 2004 |
[Do low risk patients undergoing percutaneous coronary intervention after pretreatment with clopidogrel need abciximab infusion? Results of ISAR-REACT study].
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Humans; Immunoglobulin Fab Fragments; Infusions, Parenteral; Placebos; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine; Time Factors | 2004 |
Evolution of spontaneous atherosclerotic plaque rupture with medical therapy: long-term follow-up with intravascular ultrasound.
Topics: Aged; Aspirin; Biomarkers; Clopidogrel; Coronary Artery Disease; Disease Progression; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Rupture, Spontaneous; Ticlopidine; Troponin I; Ultrasonography, Interventional | 2004 |
[Acute coronary syndrome, stroke, arterial occlusive disease. Bring the patients out of the danger zone!].
Topics: Arterial Occlusive Diseases; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Embolism, Cholesterol; Humans; Intracranial Embolism; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2004 |
[Attack on many vascular fronts. Atherothrombosis trouble seldom comes alone].
Topics: Aged; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Female; Humans; Intracranial Arteriosclerosis; Male; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
[Patients with arterial occlusive disease die of myocardial infarct or stroke. The dangerous sisters: arterial occlusive disease and coronary heart disease].
Topics: Aged; Arterial Occlusive Diseases; Aspirin; Cause of Death; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Humans; Multicenter Studies as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prognosis; Risk Factors; Stroke; Ticlopidine | 2004 |
[Combination is standard. Dual thrombocyte function inhibition in acute coronary syndrome].
Topics: Angina, Unstable; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Ticlopidine | 2004 |
[Interview with Prof. Dr. H. J. Rupprecht about secondary prevention: what is the optimal thrombocyte function inhibition?].
Topics: Angina, Unstable; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Long-Term Care; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Syndrome; Ticlopidine | 2004 |
[Secondary prevention after ischemic stroke. High risk patients need special protection].
Topics: Arteriosclerosis; Aspirin; Cerebral Infarction; Clinical Trials as Topic; Clopidogrel; Humans; Intracranial Arteriosclerosis; Long-Term Care; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 2004 |
[Primary and secondary prevention of stroke. Prevention is better than healing].
Topics: Aged; Aspirin; Cerebral Infarction; Clinical Trials as Topic; Clopidogrel; Combined Modality Therapy; Drug Therapy, Combination; Embolism, Cholesterol; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Secondary Prevention; Ticlopidine | 2004 |
Antiplatelet therapy in non-ST-segment elevation acute coronary syndromes.
Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Electrocardiography; Eptifibatide; Heparin; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Stents; Ticlopidine; Vasodilator Agents | 2004 |
Clinical and angiographic outcome after interventional treatment of the iliac arteries with a new carbofilm coated stent: preliminary results.
Topics: Administration, Oral; Aged; Aged, 80 and over; Angiography; Anticoagulants; Arterial Occlusive Diseases; Arteriosclerosis; Aspirin; Carbon; Clopidogrel; Constriction, Pathologic; Female; Fibrinolytic Agents; Follow-Up Studies; Heparin; Humans; Iliac Artery; Injections, Intravenous; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2004 |
Clopidogrel resistance.
Topics: Angina, Unstable; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Clopidogrel and postoperative bleeding.
Topics: Aprotinin; Aspirin; Blood Transfusion; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Extracorporeal Circulation; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Stents; Ticlopidine; Time Factors | 2004 |
Does clopidogrel increase blood loss following coronary artery bypass surgery?
Topics: Aged; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Critical Care; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Emergencies; Female; Humans; Intensive Care Units; Length of Stay; London; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Premedication; Prospective Studies; Risk Factors; Ticlopidine | 2004 |
Severe stenosis of anastomoses by using the symmetry aortic connector system.
Topics: Aged; Angina, Unstable; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Coronary Restenosis; Equipment Design; Female; Humans; Hyperplasia; Male; Nickel; Reoperation; Saphenous Vein; Thoracic Arteries; Ticlopidine; Titanium; Tunica Intima; Ultrasonography | 2004 |
Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting.
Topics: Aged; Atorvastatin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Pyrroles; Simvastatin; Stents; Ticlopidine | 2004 |
High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability.
Topics: Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Risk Factors; Stents; Ticlopidine | 2004 |
Clopidogrel and vascular disease prevention.
Topics: Clopidogrel; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Role of antiplatelet therapy in cardiovascular disease III: Peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Arteriosclerosis; Clopidogrel; Female; Humans; Intermittent Claudication; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Antiplatelet effects and pharmacodynamics of clopidogrel in cats.
Topics: Administration, Oral; Animals; Cats; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Serotonin; Ticlopidine; Treatment Outcome | 2004 |
Antiplatelet therapy.
Topics: Aged; Aspirin; Clopidogrel; Dipyridamole; Drug Interactions; Humans; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Stroke; Thromboembolism; Ticlopidine | 2004 |
Design, synthesis, and inhibition of platelet aggregation for some 1-o-chlorophenyl-1,2,3,4-tetrahydroisoquinoline derivatives.
Topics: Adenosine Diphosphate; Clopidogrel; Drug Design; Humans; Inhibitory Concentration 50; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Structure-Activity Relationship; Tetrahydroisoquinolines; Ticlopidine | 2004 |
Development of a score to predict the need for coronary artery bypass graft surgery in patients with non-ST segment elevation acute coronary syndromes.
Topics: Aged; Angina, Unstable; Clopidogrel; Coronary Artery Bypass; Heart Failure; Humans; Logistic Models; Middle Aged; Multivariate Analysis; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Retrospective Studies; ROC Curve; Ticlopidine | 2004 |
Spinal epidural hematoma after spinal anesthesia in a patient treated with clopidogrel and enoxaparin.
Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Clopidogrel; Enoxaparin; Female; Fibrinolytic Agents; Hematoma, Epidural, Spinal; Heparin; Humans; Leg Ulcer; Magnetic Resonance Imaging; Nervous System Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
An optimized murine model of ferric chloride-induced arterial thrombosis for thrombosis research.
Topics: Animals; Arterial Occlusive Diseases; Carotid Artery Diseases; Chlorides; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Ferric Compounds; Heparin; Kinetics; Mice; Regional Blood Flow; Research; Thrombosis; Ticlopidine | 2005 |
Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting.
Topics: Aged; Clopidogrel; Coronary Vessels; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Predictive Value of Tests; Risk Assessment; Stents; Thrombosis; Ticlopidine | 2005 |
Risk reduction with long-term clopidogrel following percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Reduction Behavior; Ticlopidine | 2004 |
I've been taking aspirin daily for 25 years, and clopidogrel fro several years. In spite of this, I've had a number of heart attacks. You reported recently on people who can't benefit from aspirin, and I think I may be one of them. What should I do?
Topics: Aspirin; Blood Coagulation Disorders; Clopidogrel; Drug Resistance; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
Comparison of two methods to assess variability of platelet response to anti-platelet therapies in patients with acute coronary syndrome undergoing angioplasty.
Topics: Abciximab; Aged; Angioplasty; Antibodies, Monoclonal; Blood Platelets; Cell Count; Clopidogrel; Edetic Acid; Female; Flow Cytometry; Fluorescent Dyes; Heart Diseases; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Risk; Ticlopidine; Time Factors | 2004 |
Spinal anaesthesia despite combined clopidogrel and aspirin therapy in a patient awaiting lung transplantation: effects of platelet transfusion on clotting tests.
Topics: Anesthesia, Spinal; Aspirin; Blood Coagulation; Clopidogrel; Female; Humans; Lung Diseases, Obstructive; Lung Transplantation; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Ticlopidine | 2005 |
Concordance between clopidogrel use and prescribing guidelines.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Australia; Clopidogrel; Cohort Studies; Coronary Artery Disease; Cost-Benefit Analysis; Cross-Sectional Studies; Drug Prescriptions; Drug Utilization Review; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Ticlopidine | 2004 |
Qualitative and quantitative analysis of clopidogrel bisulphate polymorphs.
Topics: Chemistry, Pharmaceutical; Clopidogrel; Crystallization; Evaluation Studies as Topic; India; Molecular Structure; Polymorphism, Genetic; Powders; Spectroscopy, Fourier Transform Infrared; Tablets; Ticlopidine; X-Ray Diffraction | 2004 |
[Spleen rupture in myocardial infarction after administration of GP IIb-IIIa-antagonists].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Echocardiography; Electrocardiography; Female; Fibrinolytic Agents; Heparin; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Splenectomy; Splenic Rupture; Stents; Ticlopidine; Tirofiban; Tomography, X-Ray Computed; Tyrosine | 2005 |
Impact of clopidogrel in coronary artery bypass grafting.
Topics: Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine | 2005 |
Impaired platelet responses to clopidogrel and ticlopidine in a patient with recurrent coronary stent stenosis.
Topics: Adenosine Diphosphate; Blood Platelets; Clopidogrel; Coronary Stenosis; Cyclic AMP; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine | 2004 |
Spontaneous abdominal hematoma in a patient treated with clopidogrel therapy: a case report.
Topics: Abdominal Wall; Aged; Clopidogrel; Female; Hematoma; Humans; Peritoneal Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2004 |
Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases.
Topics: Actins; Adenosine Diphosphate; Adenosine Monophosphate; Adult; Aged; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Male; Membrane Proteins; Microfilament Proteins; Middle Aged; Myocardial Ischemia; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors | 2005 |
Impact of continued hospitalization in patients pre-treated with clopidogrel prior to coronary angiography and undergoing coronary artery bypass grafting.
Topics: Aged; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Female; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Survival Analysis; Ticlopidine; Treatment Outcome; Ventricular Dysfunction, Left | 2005 |
Why don't we practice evidence-based medicine?
Topics: Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Evidence-Based Medicine; Health Knowledge, Attitudes, Practice; Hospitalization; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Ventricular Dysfunction, Left | 2005 |
[Antithrombotic therapy and dental surgery with bleeding].
Topics: Aspirin; Clopidogrel; Fibrinolytic Agents; Humans; Oral Hemorrhage; Oral Surgical Procedures; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine | 2004 |
[Two approaches to correction of disturbed hemostasis in patients with mechanical artificial heart valves at the long-term follow-up].
Topics: Aspirin; Blood Coagulation; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Follow-Up Studies; Heart Valve Prosthesis; Humans; Male; Nadroparin; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine; Treatment Outcome | 2004 |
Secondary haemorrhage after rubber band ligation of haemorrhoids in patients taking clopidogrel--a cautionary note.
Topics: Aged; Blood Transfusion; Catheterization; Clopidogrel; Female; Hemorrhoids; Humans; Ligation; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine; Treatment Outcome | 2004 |
Variability in platelet responsiveness to clopidogrel among 544 individuals.
Topics: Aged; Antigens, CD; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors | 2005 |
Subacute coronary stent thrombosis in a patient developing clopidogrel associated thrombotic thrombocytopenic purpura.
Topics: Aged; Angina, Unstable; Blood Vessel Prosthesis; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Coronary Thrombosis; Humans; Male; Platelet Aggregation Inhibitors; Prosthesis Failure; Purpura, Thrombotic Thrombocytopenic; Recurrence; Stents; Ticlopidine | 2005 |
Reducing the risks of gastrointestinal bleeding with antiplatelet therapies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Omeprazole; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2005 |
Clopidogrel-aspirin combination for atrial fibrillation: CLAAF is not CLEAR.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clinical Trials, Phase II as Topic; Clopidogrel; Drug Therapy, Combination; Feasibility Studies; Humans; Pilot Projects; Platelet Aggregation Inhibitors; Research Design; Thromboembolism; Ticlopidine; Warfarin | 2005 |
Elective percutaneous coronary intervention using broad-spectrum antiplatelet therapy (eptifibatide, clopidogrel, and aspirin) alone, without scheduled unfractionated heparin or other antithrombin therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Eptifibatide; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Retrospective Studies; Stents; Ticlopidine | 2005 |
Protective effects of clopidogrel on oxidant damage in a rat model of acute ischemia.
Topics: Animals; Clopidogrel; Disease Models, Animal; Glutathione; Ischemia; Male; Malondialdehyde; Oxidants; Oxidative Stress; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Ticlopidine | 2005 |
Reasons for inability of clopidogrel to inhibit platelet aggregation early after coronary artery bypass surgery.
Topics: Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2005 |
Long-term combination therapy with aspirin and clopidogrel.
Topics: Angina, Unstable; Arteriosclerosis; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Humans; Placebos; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Thrombosis; Ticlopidine; Treatment Outcome | 2004 |
Approach to the assessment of platelet function: comparison between optical-based platelet-rich plasma and impedance-based whole blood platelet aggregation methods.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Child; Clopidogrel; Diagnostic Tests, Routine; Electric Impedance; Humans; Male; Middle Aged; Plasma; Platelet Aggregation; Platelet Aggregation Inhibitors; Sensitivity and Specificity; Ticlopidine; Valproic Acid | 2005 |
Economic effects of prolonged clopidogrel therapy after percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Cost-Benefit Analysis; Decision Support Techniques; Drug Administration Schedule; Female; Follow-Up Studies; Health Care Costs; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2005 |
Effects of cilostazol on platelet activation in coronary stenting patients who already treated with aspirin and clopidogrel.
Topics: Aspirin; Cilostazol; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Ischemia; P-Selectin; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Tetrazoles; Thrombosis; Ticlopidine | 2004 |
Creative cost-effectiveness analysis of CAPRIE data- dust in our eyes.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Cost-Benefit Analysis; Drug Costs; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Risk Factors; Stroke; Ticlopidine | 2005 |
Rapid desensitization procedure for patients with aspirin hypersensitivity undergoing coronary stenting.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Artery Disease; Desensitization, Immunologic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Hypersensitivity; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2005 |
Carotid-artery stenting versus endarterectomy.
Topics: Angioplasty, Balloon; Carotid Stenosis; Clopidogrel; Combined Modality Therapy; Endarterectomy, Carotid; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2005 |
Carotid-artery stenting versus endarterectomy.
Topics: Angioplasty, Balloon; Carotid Stenosis; Clopidogrel; Combined Modality Therapy; Endarterectomy, Carotid; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2005 |
Summaries for patients. Is it cost-effective to treat high-risk cardiac patients with clopidogrel plus aspirin as opposed to aspirin alone?
Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Computer Simulation; Cost-Benefit Analysis; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine | 2005 |
A cost-effectiveness analysis of combination antiplatelet therapy for high-risk acute coronary syndromes: clopidogrel plus aspirin versus aspirin alone.
Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Computer Simulation; Cost-Benefit Analysis; Electrocardiography; Hemorrhage; Humans; Markov Chains; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Recurrence; Risk Factors; Sensitivity and Specificity; Stroke; Ticlopidine | 2005 |
Oral antiplatelet therapy.
Topics: Aspirin; Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Oral antiplatelet therapy.
Topics: Cerebrovascular Disorders; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Salicylates; Ticlopidine | 2005 |
Impact of combined pharmacologic treatment with clopidogrel and a statin on outcomes of patients with non-ST-segment elevation acute coronary syndromes: perspectives from a large multinational registry.
Topics: Adolescent; Adult; Aged; Angina, Unstable; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2005 |
Raising the loading dose of clopidogrel: aiming at the proper target?
Topics: Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2005 |
Clopidogrel administration prior to coronary artery bypass grafting surgery: the cardiologist's panacea or the surgeon's headache?
Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Premedication; Prospective Studies; Reoperation; Risk Factors; Thrombosis; Ticlopidine | 2005 |
Immune heparin-induced thrombocytopenia can occur in patients receiving clopidogrel and aspirin.
Topics: Adenosine Diphosphate; Adult; Aged; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Female; Heparin; Humans; Immunoenzyme Techniques; Male; Platelet Activation; Platelet Factor 4; Thrombocytopenia; Thrombolytic Therapy; Ticlopidine | 2005 |
Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses.
Topics: Adenosine Diphosphate; Animals; Axl Receptor Tyrosine Kinase; Blood Platelets; c-Mer Tyrosine Kinase; Clopidogrel; Flow Cytometry; Humans; Intercellular Signaling Peptides and Proteins; Mice; Oligopeptides; Oncogene Proteins; Peptides; Platelet Activation; Platelet Aggregation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Saccharomyces cerevisiae Proteins; Signal Transduction; Thrombosis; Ticlopidine | 2005 |
Nitroaspirin plus clopidogrel versus aspirin plus clopidogrel against platelet thromboembolism and intimal thickening in mice.
Topics: Animals; Aspirin; Blood Coagulation Tests; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Hemorrhage; Male; Mice; Mice, Inbred Strains; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Survival Rate; Thromboembolism; Ticlopidine; Tunica Intima | 2005 |
Does clopidogrel increase the degree of platelet inhibition when a platelet glycoprotein IIb/IIIa inhibitor has been given? Insights from an optical platelet aggregometry study.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Clopidogrel; Drug Combinations; Drug Interactions; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Tirofiban; Tyrosine | 2004 |
Endovascular stent-assisted angioplasty in the management of traumatic internal carotid artery dissections.
Topics: Adult; Angiography; Angioplasty; Anticoagulants; Aspirin; Blood Platelets; Blood Vessel Prosthesis Implantation; Carotid Arteries; Carotid Artery, Internal; Carotid Artery, Internal, Dissection; Clopidogrel; Constriction, Pathologic; Diffusion; Female; Humans; Ischemia; Male; Middle Aged; Perfusion; Prognosis; Stents; Stroke; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Wounds and Injuries | 2005 |
Erythromelalgia as a presenting manifestation in a patient with essential thrombocythemia complicating renovascular hypertension due to unilateral renal artery stenosis.
Topics: Adult; Angiography; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Marrow; Clopidogrel; Diagnosis, Differential; Drug Therapy, Combination; Erythromelalgia; Female; Humans; Hypertension, Renovascular; Platelet Aggregation Inhibitors; Renal Artery; Renal Artery Obstruction; Thrombocytosis; Ticlopidine; Treatment Outcome | 2005 |
Dual antiplatelet therapy for coronary stenting: a clear path for a research agenda.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Eptifibatide; Hemorrhage; Length of Stay; Membrane Proteins; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Premedication; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Risk Factors; Stents; Thrombophilia; Ticlopidine | 2005 |
Concurrent antiplatelet and fibrinolytic therapy.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 2005 |
The long-term cost-effectiveness of clopidogrel plus aspirin in patients undergoing percutaneous coronary intervention in Sweden.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Computer Simulation; Coronary Disease; Cost-Benefit Analysis; Drug Administration Schedule; Drug Costs; Drug Therapy, Combination; Female; Humans; Logistic Models; Male; Markov Chains; Middle Aged; Models, Economic; Monte Carlo Method; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2005 |
Multiple antiplatelet effects of clopidogrel are not modulated by statin type in patients undergoing percutaneous coronary intervention.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Atorvastatin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Evaluation; Drug Interactions; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Simvastatin; Ticlopidine | 2004 |
Effect of clopidogrel with and without aspirin on bleeding following transbronchial lung biopsy.
Topics: Animals; Aspirin; Biopsy, Needle; Bronchoscopy; Clopidogrel; Hemorrhage; Lung; Platelet Aggregation Inhibitors; Swine; Ticlopidine | 2005 |
Clopidogrel-related refractory bleeding after coronary artery bypass graft surgery: a rationale for the use of coagulation factor concentrates?
Topics: Clopidogrel; Coronary Artery Bypass; Coronary Restenosis; Drug Administration Schedule; Factor VIIa; Factor XIII; Fibrinogen; Hemorrhage; Hemostasis, Surgical; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recombinant Proteins; Reoperation; Retreatment; Ticlopidine; Treatment Outcome | 2005 |
Repetitive profound thrombocytopenia after treatment with tirofiban: a case report.
Topics: Angioplasty, Balloon; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Drug Administration Schedule; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Thrombocytopenia; Ticlopidine; Tirofiban; Tyrosine | 2004 |
Heart-protective drugs: a primer. Back to basics on how they work, side effects, interactions.
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Calcium Channel Blockers; Clopidogrel; Diuretics; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2004 |
[Inhibitory effects of aspirin, clopidogrel, and their combination on the progression of atherosclerosis in rabbits].
Topics: Animals; Aorta; Aspirin; Atherosclerosis; C-Reactive Protein; Cell Count; Clopidogrel; Cyclooxygenase Inhibitors; Drug Synergism; Macrophages; Male; Myocytes, Smooth Muscle; Platelet Aggregation Inhibitors; Rabbits; Random Allocation; Ticlopidine | 2005 |
Anaesthetic considerations in a parturient with critical coronary artery disease and a drug-eluting stent presenting for caesarean section.
Topics: Adult; Anesthesia, Obstetrical; Cesarean Section; Clopidogrel; Coronary Disease; Female; Humans; Pregnancy; Pregnancy Complications, Cardiovascular; Stents; Ticlopidine | 2005 |
P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Coronary Disease; Female; Genotype; Haplotypes; Humans; Male; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Cell Surface; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2005 |
In-hospital patients exposed to clopidogrel before coronary artery bypass graft surgery: a word of caution.
Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Female; Heparin; Hospital Mortality; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Referral and Consultation; Stroke; Ticlopidine | 2005 |
Emerging therapies: clopidogrel and aspirin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prevalence; Research Design; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
Unstable angina, stroke, myocardial infarction and death in aspirin non-responders. A prospective, randomized trial. The ASCET (ASpirin non-responsiveness and Clopidogrel Endpoint Trial) design.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Infarction; Norway; Platelet Aggregation Inhibitors; Prospective Studies; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Stroke; Ticlopidine | 2004 |
Ask the doctors. I had angioplasty and have one stent. My cardiologist says that I don't need to take clopidogrel (Plavix) plus aspirin. He says one or the other is okay. I'm taking clopidogrel, but notice that advertising for the medication suggest coupl
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2005 |
Who needs Plavix? This super aspirin is meant mainly for people at high risk of having a heart attack or stroke.
Topics: Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Assessment; Stroke; Ticlopidine | 2005 |
Drug therapy during percutaneous coronary interventions in stable and unstable coronary artery disease: the Italian Drug Evaluation in Angioplasty (IDEA) study.
Topics: Acetylcysteine; Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Utilization Review; Female; Health Care Surveys; Heparin; Humans; Italy; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Pyridines; Registries; Ticlopidine | 2005 |
Neurological outcome of conservative versus endovascular treatment of patients with asymptomatic high-grade carotid artery stenosis: a propensity score-adjusted analysis.
Topics: Aged; Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Severity of Illness Index; Stents; Stroke; Ticlopidine; Treatment Outcome; Ultrasonography | 2005 |
Inhibitory effects of P2Y12 receptor antagonists on TRAP-induced platelet aggregation, procoagulant activity, microparticle formation and intracellular calcium responses in patients with acute coronary syndromes.
Topics: Adenosine Monophosphate; Calcium Signaling; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Receptors, Thrombin; Ticlopidine | 2005 |
Bleeding complications associated with combinations of aspirin, thienopyridine derivatives, and warfarin in elderly patients following acute myocardial infarction.
Topics: Age Factors; Aged; Anticoagulants; Aspirin; Case-Control Studies; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Warfarin | 2005 |
A patient with stent thrombosis, clopidogrel-resistance and failure to metabolize clopidogrel to its active metabolite.
Topics: Aged; Aspirin; Biotransformation; Clopidogrel; Drug Monitoring; Drug Resistance; Humans; Male; Platelet Aggregation; Stents; Thrombosis; Ticlopidine | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding.
Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Secondary Prevention; Ticlopidine | 2005 |
Design and rationale of Clopidogrel as Adjunctive Reperfusion Therapy-Thrombolysis in Myocardial Infarction (CLARITY-TIMI) 28 trial.
Topics: Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Multicenter Studies as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Research Design; Thrombolytic Therapy; Ticlopidine | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding.
Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Cost Savings; Drug Therapy, Combination; Fees, Pharmaceutical; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2005 |
Clopidogrel versus aspirin and esomeprazole to prevent recurrent bleeding.
Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Contraindications; Drug Therapy, Combination; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Secondary Prevention; Ticlopidine | 2005 |
Effects of clopidogrel and high dose aspirin on survival of skin flaps in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Rats; Rats, Wistar; Surgical Flaps; Ticlopidine; Tissue Survival | 2005 |
Clopidogrel pretreatment for percutaneous coronary intervention: double, double, dose in trouble?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhibitors; Premedication; Ticlopidine | 2005 |
Counting the true cost of antiplatelet therapy for stroke prevention.
Topics: Aged; Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Drug Combinations; Female; Gastrointestinal Diseases; Humans; Male; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine; United Kingdom | 2005 |
Why clopidogrel failed to inhibit platelet function early after coronary artery bypass surgery: to load or not to load, and is it a question of resistance?
Topics: Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Postoperative Care; Research Design; Ticlopidine; Time Factors; Treatment Failure | 2005 |
Endovascular treatment of popliteal artery aneurysms: results of a prospective cohort study.
Topics: Aged; Aged, 80 and over; Aneurysm; Angioplasty; Blood Vessel Prosthesis Implantation; Clopidogrel; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Popliteal Artery; Prospective Studies; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2005 |
Cost-effectiveness of clopidogrel.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Cost-Benefit Analysis; Embolism, Cholesterol; Humans; Myocardial Infarction; Ticlopidine | 2004 |
[Antiplatelet agents and regional anaesthesia: experience in 130 patients].
Topics: Aged; Aspirin; Autonomic Nerve Block; Blood Loss, Surgical; Blood Vessel Prosthesis Implantation; Clopidogrel; Endarterectomy, Carotid; Hematoma; Hemorrhage; Humans; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Prospective Studies; Punctures; Risk; Ticlopidine | 2005 |
Modelling the long term cost effectiveness of clopidogrel for the secondary prevention of occlusive vascular events in the UK.
Topics: Aged; Aspirin; Clopidogrel; Cost-Benefit Analysis; Female; Humans; Male; Markov Chains; Middle Aged; Models, Economic; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Ticlopidine; United Kingdom; Vascular Diseases | 2005 |
[Aspirin and cardiovascular prevention: last minute information].
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Ticlopidine | 2005 |
[Exercise-induced left arm pain and thrombocytosis].
Topics: Angioplasty, Balloon, Coronary; Bone Marrow Examination; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Stenosis; Coronary Thrombosis; Diagnosis, Differential; Electrocardiography; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Count; Risk Factors; Smoking; Stents; Thrombocythemia, Essential; Ticlopidine | 2005 |
Very late thrombosis after implantation of sirolimus eluting stent.
Topics: Adult; Aspirin; Blood Vessel Prosthesis; Catheterization; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Coronary Thrombosis; Drug Implants; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Male; Platelet Aggregation Inhibitors; Prosthesis Failure; Retreatment; Sirolimus; Stents; Ticlopidine; Time Factors | 2005 |
Loading, pretreatment, and interindividual variability issues with clopidogrel dosing.
Topics: Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2005 |
Neurofibromatosis as a cause of multiple coronary aneurysms.
Topics: Adrenergic beta-Antagonists; Aged; Aspirin; Clopidogrel; Coronary Aneurysm; Coronary Angiography; Female; Humans; Neurofibromatoses; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery disease.
Topics: Aged; Alleles; Aspirin; Brain Ischemia; Cerebrovascular Circulation; Clopidogrel; Cohort Studies; Exons; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heterozygote; Humans; Ischemia; Membrane Proteins; Middle Aged; Mutation; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Prevalence; Proportional Hazards Models; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2005 |
Letter regarding article by Mehilli et al, "randomized clinical trial of abciximab in diabetic patients undergoing elective percutaneous coronary interventions after treatment with a high loading dose of clopidogrel".
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clinical Protocols; Clopidogrel; Diabetic Angiopathies; Dose-Response Relationship, Drug; Humans; Immunoglobulin Fab Fragments; Randomized Controlled Trials as Topic; Ticlopidine | 2005 |
Estimation of carboxylic acid metabolite of clopidogrel in Wistar rat plasma by HPLC and its application to a pharmacokinetic study.
Topics: Animals; Carboxylic Acids; Chromatography, High Pressure Liquid; Clopidogrel; Drug Stability; Male; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine | 2005 |
Stent thrombosis is associated with an impaired response to antiplatelet therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Thrombosis; Ticlopidine | 2005 |
Enhanced shear-induced platelet aggregation in patients who experience subacute stent thrombosis: a case-control study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Case-Control Studies; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Thrombosis; Ticlopidine | 2005 |
Resistance to antiplatelet resistance is it justified?
Topics: Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2005 |
[In diabetes and peripheral arterial occlusive disease: long-term treatment with clopidogrel].
Topics: Arterial Occlusive Diseases; Clinical Trials as Topic; Clopidogrel; Diabetic Angiopathies; Humans; Long-Term Care; Platelet Aggregation Inhibitors; Survival Analysis; Ticlopidine | 2005 |
Technique of left main stenting is dependent on lesion location and distal branch protection.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis Implantation; Clopidogrel; Coated Materials, Biocompatible; Coronary Angiography; Coronary Stenosis; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; North Carolina; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Stroke Volume; Ticlopidine; Treatment Outcome | 2005 |
Is clopidogrel the antiplatelet drug of choice for high-risk patients with stroke/TIA?: Yes.
Topics: Clinical Trials as Topic; Clopidogrel; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Ticlopidine | 2005 |
Is clopidogrel the antiplatelet drug of choice for high-risk patients with stroke/TIA?: No.
Topics: Clopidogrel; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2005 |
The value of clopidogrel administered postoperatively following a non-ST-segment elevation acute coronary syndrome.
Topics: Clopidogrel; Coronary Artery Bypass; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Humans; Male; Myocardial Infarction; Postoperative Complications; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Ticlopidine; Treatment Outcome | 2005 |
Validation of predictors of intraprocedural stent thrombosis in the drug-eluting stent era.
Topics: Acute Disease; Anticoagulants; Antineoplastic Agents, Phytogenic; Blood Vessel Prosthesis Implantation; Clopidogrel; Coated Materials, Biocompatible; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Drug Therapy, Combination; Electrocardiography; Female; Heparin; Humans; Intraoperative Complications; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Predictive Value of Tests; Pyridines; Retrospective Studies; Stents; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2005 |
Importance of timing of antiaggregant treatment in the prevention of radiation induced enteropathy.
Topics: Apoptosis; Clopidogrel; Endothelial Cells; Humans; Platelet Aggregation Inhibitors; Radiation Injuries; Radiotherapy; Ticlopidine; Time Factors | 2005 |
The (variable) definition of benefit in the case of clopidogrel vs aspirin.
Topics: Aspirin; Clopidogrel; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome; Vascular Diseases | 2005 |
Variation in the ability of glycoprotein IIb-IIIa antagonists to exert and maintain their inhibitory effects on the binding of fibrinogen.
Topics: Adenosine Diphosphate; Aged; Binding, Competitive; Blood Platelets; Clopidogrel; Coronary Artery Disease; Data Interpretation, Statistical; Eptifibatide; Fibrinogen; Flow Cytometry; Fluorescein-5-isothiocyanate; Humans; Iodine Radioisotopes; Male; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Ticlopidine; Tirofiban; Tyrosine | 2005 |
Intense migraines secondary to percutaneous closure of atrial septal defects.
Topics: Adult; Cardiac Catheterization; Clopidogrel; Echocardiography, Transesophageal; Female; Follow-Up Studies; Heart Septal Defects, Atrial; Humans; Male; Migraine without Aura; Minimally Invasive Surgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Severity of Illness Index; Ticlopidine; Time Factors; Treatment Outcome | 2005 |
Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk.
Topics: Adenosine Diphosphate; Adult; Aged; Blood Platelets; Calcium Signaling; Case-Control Studies; Clopidogrel; Diabetes Mellitus, Type 2; Humans; In Vitro Techniques; Membrane Proteins; Middle Aged; Phosphatidylserines; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stroke; Thrombin; Thrombosis; Ticlopidine | 2005 |
P-selectin (CD62p) and P-selectin glycoprotein ligand-1 (PSGL-1) polymorphisms: minor phenotypic differences in the formation of platelet-leukocyte aggregates and response to clopidogrel.
Topics: Blood Platelets; Clopidogrel; Humans; Leukocytes; Membrane Glycoproteins; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2005 |
Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction.
Topics: Aspirin; Clopidogrel; Coronary Circulation; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Myocardial Infarction; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Vascular Patency | 2005 |
Clopidogrel (Plavix) desensitization: a case series.
Topics: Aged; Clopidogrel; Desensitization, Immunologic; Erythema; Exanthema; Female; Humans; Male; Platelet Aggregation Inhibitors; Pruritus; Ticlopidine | 2005 |
Total knee replacement in a patient taking clopidogrel.
Topics: Aged; Arthroplasty, Replacement, Knee; Bleeding Time; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Use of native or platelet count adjusted platelet rich plasma for platelet aggregation measurements.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Monitoring; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Thrombocytosis; Ticlopidine | 2005 |
Enhancing reperfusion therapy for myocardial infarction with dual antiplatelet therapy: Breaking the glass ceiling.
Topics: Aspirin; Clopidogrel; Coronary Circulation; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Streptokinase; Thrombolytic Therapy; Ticlopidine | 2005 |
[Highlights from the American College of Cardiology Annual Scientific Session 2005: March 5-9, 2005, Orlando, Florida].
Topics: Aspirin; Cardiovascular Diseases; Cholesterol, LDL; Clopidogrel; Humans; Hypercholesterolemia; Obesity; Piperidines; Platelet Aggregation Inhibitors; Pyrazoles; Rimonabant; Stroke; Ticlopidine | 2005 |
Lack of antiapoptotic effects of antiplatelet drug, aspirin and clopidogrel, and antioxidant, MCI-186, against focal ischemic brain damage in rats.
Topics: Animals; Antioxidants; Antipyrine; Aspirin; bcl-2-Associated X Protein; Blotting, Western; Brain Edema; Brain Ischemia; Cerebral Infarction; Clopidogrel; Cyclic AMP Response Element-Binding Protein; Disability Evaluation; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Administration Routes; Edaravone; Functional Laterality; Gene Expression Regulation; Hypoxia, Brain; Male; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Ticlopidine; Tumor Suppressor Proteins | 2005 |
Serious clopidogrel associated renal hematoma in a type 2 diabetic patient with primary hyperparathyroidism after extracorporeal shock wave lithotripsy.
Topics: Clopidogrel; Diabetes Mellitus, Type 2; Hematoma; Humans; Hyperparathyroidism, Primary; Kidney Calculi; Kidney Diseases; Lithotripsy; Male; Middle Aged; Nephrectomy; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
[The efficacy of surgical and conservative methods in secondary prevention of carotid ischemic stroke].
Topics: Aged; Brain; Brain Ischemia; Carotid Stenosis; Cerebral Arteries; Clopidogrel; Combined Modality Therapy; Endarterectomy, Carotid; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Surgical Flaps; Ticlopidine; Ultrasonography | 2005 |
Clopidogrel as antithrombotic therapy in atrial fibrillation.
Topics: Atrial Fibrillation; Atrial Flutter; Clopidogrel; Electric Countershock; Evidence-Based Medicine; Fibrinolytic Agents; Heparin; Heparin, Low-Molecular-Weight; Humans; International Normalized Ratio; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Vitamin K | 2005 |
Cost of care for new-onset acute coronary syndrome patients who undergo coronary revascularization.
Topics: Acute Disease; Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Angina, Unstable; Clopidogrel; Female; Health Care Costs; Health Services Needs and Demand; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Managed Care Programs; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Prospective Studies; Ticlopidine; Time Factors; United States | 2005 |
The inhibitory potency of clopidogrel on ADP-induced platelet activation is not attenuated when it is co-administered with atorvastatin (20 mg/day) for 5 weeks in patients with acute coronary syndromes.
Topics: Acute Disease; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Atorvastatin; Blood Platelets; CD40 Ligand; Cholesterol; Cholesterol, LDL; Clopidogrel; Coronary Disease; Drug Administration Schedule; Drug Interactions; Female; Flow Cytometry; Heptanoic Acids; Humans; Male; Middle Aged; P-Selectin; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine; Triglycerides | 2005 |
Intracranial bleeding associated with clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Antihypertensive Agents; Clopidogrel; Coronary Stenosis; Humans; Hypertension; Intracranial Hemorrhages; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine; Tomography, X-Ray Computed | 2005 |
A cost-utility analysis of clopidogrel in patients with non-ST-segment-elevation acute coronary syndromes in the UK.
Topics: Acute Disease; Aged; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Drug Costs; Electrocardiography; Humans; Markov Chains; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
[Conservative treatment of lower limb chronic obliterative atherosclerosis: strategy and tactics].
Topics: Arteriosclerosis Obliterans; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Lower Extremity; Middle Aged; Pentoxifylline; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Comparative effect of antiplatelet therapy in retinal vein occlusion evaluated by the particle-counting method using light scattering.
Topics: Aspirin; Clopidogrel; Epoprostenol; Humans; Light; Particle Size; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Retinal Vein Occlusion; Scattering, Radiation; Ticlopidine | 2005 |
Evaluation of clopidogrel resistance.
Topics: Adenosine Diphosphate; Biological Availability; Blood Platelets; Clopidogrel; Drug Resistance; Humans; In Vitro Techniques; Membrane Proteins; Mutation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2005 |
[Strokes associated with cervical artery dissection, and systemic mastocytosis: an unfortuitous association? A report of two cases].
Topics: Aspirin; Brain Infarction; Carotid Artery, Internal, Dissection; Carotid Stenosis; Clopidogrel; Fibrinolytic Agents; Follow-Up Studies; Humans; Magnetic Resonance Angiography; Male; Mastocytosis, Systemic; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Time Factors; Vertebral Artery Dissection | 2005 |
Effect of clopidogrel on the expression of inflammatory markers in rabbit ischemic coronary artery.
Topics: Animals; Anti-Inflammatory Agents; CD40 Ligand; Clopidogrel; Coronary Vessels; Disease Models, Animal; Male; Myocardial Ischemia; P-Selectin; Platelet Aggregation Inhibitors; Rabbits; Thromboplastin; Ticlopidine | 2005 |
Combined pharmacologic treatment with clopidogrel and statin for patients with acute coronary syndrome: is there a survival advantage?
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Combinations; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Prospective Studies; Randomized Controlled Trials as Topic; Survival Analysis; Ticlopidine | 2005 |
Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Inflammatory response after intervention assessed by serial C-reactive protein measurements correlates with restenosis in patients treated with coronary stenting.
Topics: Abciximab; Aged; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Biomarkers; C-Reactive Protein; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Female; Heparin; Humans; Immunoglobulin Fab Fragments; Inflammation; Male; Middle Aged; Postoperative Period; Premedication; Stents; Ticlopidine; Tirofiban; Tyrosine | 2005 |
Use of antiplatelet drugs in the stroke unit of a Hong Kong hospital.
Topics: Aged; Analysis of Variance; Clopidogrel; Drug Prescriptions; Drug Utilization; Female; Hong Kong; Hospital Units; Hospitals; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Ticlopidine | 2005 |
Increased long term rates of stent thrombosis and mortality in patients given clopidogrel as compared to ticlopidine following coronary stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine | 2005 |
Clopidogrel linking evaluation of platelet response variability to mechanism of action.
Topics: Blood Platelets; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Time Factors; Treatment Outcome | 2005 |
Progressive symptomatic carotid dissection treated with multiple stents.
Topics: Angiography; Angioplasty; Anticoagulants; Aspirin; Blood Vessel Prosthesis Implantation; Carotid Artery, Internal; Carotid Artery, Internal, Dissection; Clopidogrel; Constriction, Pathologic; Follow-Up Studies; Humans; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine; Time Factors | 2005 |
Not all statins interfere with clopidogrel during antiplatelet therapy.
Topics: Adult; Atorvastatin; Chromatography, High Pressure Liquid; Clopidogrel; Drug Interactions; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Ticlopidine | 2005 |
Clopidogrel reduces migraine with aura after transcatheter closure of persistent foramen ovale and atrial septal defects.
Topics: Adult; Aspirin; Cardiac Catheterization; Clopidogrel; Drug Therapy, Combination; Female; Heart Septal Defects, Atrial; Humans; Male; Medical Audit; Middle Aged; Migraine with Aura; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Ticlopidine | 2005 |
[Does antiaggregant therapy have a place in type II heparin-induced thrombocytopenia?].
Topics: Aged; Clopidogrel; Fatal Outcome; Female; Fibrinolytic Agents; Heparin; Humans; Platelet Aggregation Inhibitors; Thrombocytopenia; Ticlopidine | 2005 |
[Clopidogrel and upper gastrointestinal hemorrhage].
Topics: Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Ticlopidine | 2005 |
Pharmacological properties of YM-254890, a specific G(alpha)q/11 inhibitor, on thrombosis and neointima formation in mice.
Topics: Administration, Oral; Animals; Blood Pressure; Carotid Arteries; Cell Proliferation; Chlorides; Chromones; Clopidogrel; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ferric Compounds; GTP-Binding Protein alpha Subunits, Gq-G11; Heart Rate; Male; Mice; Mice, Inbred ICR; Models, Chemical; Morpholines; Muscle, Smooth; Muscle, Smooth, Vascular; Peptides, Cyclic; Platelet Aggregation; Thrombosis; Ticlopidine; Time Factors; Tunica Intima | 2005 |
Clopidogrel "resistance" and statin cotreatment - significant for cardiocoronary prevention in real life?
Topics: Blood Platelets; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2005 |
The antiplatelet effect of clopidogrel is not attenuated by statin treatment in stable patients with ischemic heart disease.
Topics: Aged; Atorvastatin; Blood Platelets; Cholesterol, LDL; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Heart Diseases; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Simvastatin; Ticlopidine; Time Factors; Wound Healing | 2005 |
[Prophylaxis of stroke].
Topics: Age Factors; Aged; Angioplasty, Balloon; Anticoagulants; Antihypertensive Agents; Aspirin; Atrial Fibrillation; Brain Ischemia; Carotid Stenosis; Clopidogrel; Coronary Disease; Diabetes Mellitus; Diet; Drug Therapy, Combination; Endarterectomy, Carotid; Exercise; Female; Humans; Hypertension; Hypolipidemic Agents; Life Style; Male; Middle Aged; Platelet Aggregation Inhibitors; Primary Prevention; Risk Factors; Sex Factors; Smoking Cessation; Stents; Stroke; Ticlopidine; Time Factors | 2005 |
[Stenting plus coiling: dangerous or helpful?].
Topics: Acute Disease; Aneurysm, Ruptured; Angiography, Digital Subtraction; Aspirin; Calcium Channel Blockers; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Follow-Up Studies; Humans; Intracranial Aneurysm; Nimodipine; Platelet Aggregation Inhibitors; Platinum; Risk Factors; Stents; Subarachnoid Hemorrhage; Ticlopidine; Time Factors; Treatment Outcome; Vasodilator Agents | 2005 |
Plavix reduces death risk following a heart attack.
Topics: Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine | 2005 |
The clinical variability of Wallenberg's syndrome. The anatomical correlate of ipsilateral axial lateropulsion.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Brain; Cerebral Infarction; Clopidogrel; Dipyridamole; Functional Laterality; Gait Disorders, Neurologic; Heparin; Humans; Lateral Medullary Syndrome; Magnetic Resonance Imaging; Male; Medulla Oblongata; Neurologic Examination; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Hospitals improve heart attack care. As compliance with guidelines improves, in-hospital deaths fall.
Topics: Aspirin; Cardiac Catheterization; Clopidogrel; Electrocardiography; Guideline Adherence; Hospital Mortality; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Secondary stroke prevention with antiplatelet therapy with emphasis on the cardiac patient: a neurologist's view.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Neurology; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2005 |
Clopidogrel for percutaneous coronary revascularization: time for more pretreatment, retreatment, or both?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Ask the doctors. My mother in her early 90s has been diagnosed with atherosclerosis, had a successful angioplasty a year ago for severe chest pain, takes clopidogrel and aspirin, and in general eats a low-fat diet, although she really likes melted ice cre
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Artery Disease; Diet, Fat-Restricted; Exercise; Female; Humans; Hypolipidemic Agents; Ice Cream; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Stent thrombosis in patients treated with thienopyridines: clinical description of 10 cases.
Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Radiography; Retrospective Studies; Risk Factors; Severity of Illness Index; Stents; Ticlopidine | 2004 |
Does clopidogrel improve the long-term outcome after coronary artery bypass surgery?
Topics: Clopidogrel; Coronary Artery Bypass; Coronary Restenosis; Coronary Stenosis; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome | 2005 |
Adverse reactions to anticoagulants and to antiplatelet drugs recorded by the German spontaneous reporting system.
Topics: Administration, Oral; Adverse Drug Reaction Reporting Systems; Anticoagulants; Aspirin; Association; Blood Cell Count; Cerebral Hemorrhage; Clopidogrel; Databases, Factual; Drug Information Services; Germany; Hemorrhage; Heparin; Humans; Phenprocoumon; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Thrombocytopenia; Ticlopidine; Time Factors; Treatment Outcome; Vitamin K | 2005 |
Flow cytometric measurement of platelet-leukocyte aggregates: a possible target to monitor platelet function?
Topics: Adenosine Diphosphate; Adult; Arterial Occlusive Diseases; Aspirin; Blood Platelets; Clopidogrel; Flow Cytometry; Heart Diseases; Humans; Leukocytes; Male; Monocytes; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk; Ticlopidine | 2005 |
Role of the retention test Homburg in evaluating platelet hyperactivity and in monitoring therapy with antiplatelet drugs.
Topics: Abciximab; Adenosine Diphosphate; Antibodies, Monoclonal; Aspirin; Blood Platelets; Cell Shape; Clopidogrel; Collagen; Drug Monitoring; Humans; Immunoglobulin Fab Fragments; P-Selectin; Pilot Projects; Plasma; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Prostaglandins; Ristocetin; Ticlopidine | 2005 |
Is platelet adhesion assay able to quantify drug-induced platelet dysfunction?
Topics: Abciximab; Aged; Antibodies, Monoclonal; Blood Platelet Disorders; Blood Platelets; Cell Separation; Clopidogrel; Dose-Response Relationship, Drug; Eptifibatide; Female; Fibrinogen; Flow Cytometry; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Peptides; Platelet Adhesiveness; Platelet Aggregation; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymers; Pyridines; Ticlopidine; Tirofiban; Tyrosine | 2005 |
Investigation of the PADA as a method for monitoring GPIIb/IIIa inhibitors and other antiplatelet agents.
Topics: Abciximab; Adenosine Monophosphate; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Monitoring; Eptifibatide; Hirudins; Humans; Immunoglobulin Fab Fragments; Peptides; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Sensitivity and Specificity; Ticlopidine | 2005 |
Intralamellar haemorrhage 44 years following lamellar keratoplasty.
Topics: Blindness; Clopidogrel; Corneal Neovascularization; Corneal Transplantation; Eye Hemorrhage; Humans; Keratitis, Herpetic; Male; Myocardial Ischemia; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Recurrence; Ticlopidine; Time Factors; Visual Acuity | 2006 |
Oral clopidogrel load in aspirin-resistant capsular warning syndrome.
Topics: Administration, Oral; Aged; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Internal Capsule; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Syndrome; Ticlopidine | 2005 |
The antithrombotic effect of melagatran in combination with clopidogrel and/or aspirin (carotid artery primary thrombosis study).
Topics: Animals; Aspirin; Azetidines; Benzylamines; Bleeding Time; Blood Flow Velocity; Blood Pressure; Carotid Artery Thrombosis; Carotid Artery, Common; Clopidogrel; Disease Models, Animal; Dogs; Drug Therapy, Combination; Female; Fibrinolytic Agents; Heart Rate; Male; Partial Thromboplastin Time; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Ticlopidine; Tongue; Vascular Patency | 2005 |
Molecular mechanism of Clopidogrel and Aspirin therapy-induced bleeding episodes.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Eicosanoids; Hemorrhage; Humans; Ticlopidine | 2006 |
Aspirin, but not clopidogrel, reduces collateral conductance in a rabbit model of femoral artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Disease Models, Animal; Electrophysiology; Femoral Artery; Rabbits; Ticlopidine | 2005 |
Clopidogrel use for reducing the rate of thrombosis in a rat model of microarterial anastomosis.
Topics: Anastomosis, Surgical; Animals; Clopidogrel; Double-Blind Method; Femoral Artery; Male; Microsurgery; Models, Animal; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Thrombosis; Ticlopidine; Treatment Outcome; Vascular Patency | 2005 |
Cost-effectiveness of clopidogrel plus aspirin versus aspirin alone.
Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2005 |
Cost-effectiveness of clopidogrel plus aspirin versus aspirin alone.
Topics: Angina, Unstable; Aspirin; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2005 |
Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Membrane Proteins; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2005 |
Management and prevention of thrombotic stent occlusion.
Topics: Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis; Clopidogrel; Emergency Treatment; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2005 |
Pharmacotherapy of acute coronary syndromes: medical economics with an emphasis on clopidogrel.
Topics: Acute Disease; Clopidogrel; Cost-Benefit Analysis; Drug Costs; Economics, Medical; Fibrinolytic Agents; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Ticlopidine | 2005 |
P >0.05 not equal equivalent or noninferior.
Topics: Angioplasty, Balloon, Coronary; Cilostazol; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Research Design; Stents; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2005 |
Spontaneous epidural haematoma presenting as cord compression in a patient receiving clopidogrel.
Topics: Clopidogrel; Hematoma, Epidural, Spinal; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Spinal Cord Compression; Ticlopidine | 2005 |
Prevention of stroke recurrence.
Topics: Aged; Clopidogrel; Dipyridamole; Endarterectomy, Carotid; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine; Warfarin | 2003 |
PAR-1 genotype influences platelet aggregation and procoagulant responses in patients with coronary artery disease prior to and during clopidogrel therapy.
Topics: Alleles; Blood Coagulation Factors; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genetic Variation; Genotype; Homozygote; Humans; Male; Membrane Proteins; Middle Aged; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptor, PAR-1; Receptors, Purinergic P2Y12; Receptors, Thrombin; Ticlopidine | 2005 |
Serial changes in platelet activation in patients with unstable angina following coronary stenting: evaluation of the effects of clopidogrel loading dose in inhibiting platelet activation.
Topics: Aged; Angina, Unstable; Clopidogrel; Drug Evaluation; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2005 |
Economic effects of extended clopidogrel therapy--a word of caution.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine | 2005 |
Clopidogrel-induced hypersensitivity syndrome associated with febrile pancytopenia.
Topics: Administration, Oral; Clopidogrel; Drug Eruptions; Erythema; Fever; Humans; Male; Middle Aged; Pancytopenia; Platelet Aggregation Inhibitors; Skin Diseases; Syndrome; Ticlopidine | 2005 |
What is the best measure of thrombotic risks--pretreatment platelet aggregation, clopidogrel responsiveness, or posttreatment platelet aggregation?
Topics: Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2005 |
Can N-acetylcysteine reverse the antiplatelet effects of clopidogrel? An in vivo and vitro study.
Topics: Acetylcysteine; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2005 |
[Cerebral secondary prevention--clopidogrel alone or in combination with ASS].
Topics: Aged; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Intracranial Hemorrhages; Ischemic Attack, Transient; Male; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine; Treatment Outcome | 2005 |
Clopidogrel hypersensitivity syndrome with rash, fever, and neutropenia.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Drug Hypersensitivity; Female; Fever; Humans; Nausea; Neutropenia; Platelet Aggregation Inhibitors; Stents; Syndrome; Tachycardia; Ticlopidine; Vomiting | 2005 |
Feasibility trial of carotid stenting with and without an embolus protection device.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Vessel Prosthesis Implantation; Carotid Artery, Common; Carotid Stenosis; Clopidogrel; Feasibility Studies; Female; Graft Occlusion, Vascular; Humans; Intracranial Embolism; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Radiography; Stents; Stroke; Survival Rate; Ticlopidine; Treatment Outcome | 2005 |
Procedure-related complications and early neurological adverse events of unprotected and protected carotid stenting: temporal trends in a consecutive patient series.
Topics: Aged; Aspirin; Blood Vessel Prosthesis Implantation; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Stents; Stroke; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2005 |
Antiplatelet therapy and the vascular tree.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2006 |
Clopidogrel-induced hepatotoxicity after percutaneous coronary stenting.
Topics: Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Combined Modality Therapy; Coronary Disease; Humans; Male; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2005 |
[ASS or clopidogrel plus esomeprazole after bleeding from an ulcer].
Topics: Aged; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Esomeprazole; Female; Humans; Male; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Secondary Prevention; Ticlopidine | 2005 |
Use of evidence-based management for acute coronary syndrome.
Topics: Acute Disease; Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Cardiology; Clopidogrel; Coronary Angiography; Coronary Disease; Evidence-Based Medicine; Female; Guideline Adherence; Heparin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Revascularization; New Zealand; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Retrospective Studies; Thrombolytic Therapy; Ticlopidine | 2005 |
ST-elevation myocardial infarction: New Zealand management guidelines.
Topics: Aged; Aspirin; Biomarkers; Cardiology; Clopidogrel; Contraindications; Creatine Kinase; Drug Monitoring; Echocardiography; Electrocardiography; Evidence-Based Medicine; Fibrinolytic Agents; Humans; Myocardial Infarction; Myocardial Revascularization; New Zealand; Platelet Aggregation Inhibitors; Risk Assessment; Thrombolytic Therapy; Ticlopidine; Troponin | 2005 |
Idiopathic spontaneous coronary artery dissection and drug-eluting stents.
Topics: Adult; Aortic Dissection; Aspirin; Clopidogrel; Coronary Aneurysm; Coronary Angiography; Female; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2006 |
Early endotoxin-mediated haemostatic and inflammatory responses in the clopidogrel-treated pig.
Topics: Animals; Blood Platelets; Blood Pressure; Clopidogrel; Creatinine; Endotoxins; Female; Hemostasis; Humans; Inflammation; Interleukin-6; Male; Oxygen; Platelet Aggregation Inhibitors; Random Allocation; Swine; Ticlopidine; Tumor Necrosis Factor-alpha | 2005 |
Stent thrombosis is associated with an impaired response to antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Humans; Risk Factors; Stents; Thrombosis; Ticlopidine | 2005 |
Letter regarding article by Patti et al, "Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (Antiplatelet therapy for Reductio
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Letter regarding article by Patti et al, "Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (Antiplatelet therapy for Reductio
Topics: Clopidogrel; Coronary Artery Bypass; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Preoperative Care; Ticlopidine | 2005 |
Does combined clopidogrel and statin therapy benefit patients with non-ST-elevation myocardial infarction?
Topics: Adult; Aged; Aspirin; Clopidogrel; Cohort Studies; Confidence Intervals; Coronary Angiography; Drug Therapy, Combination; Electrocardiography; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Probability; Prognosis; Registries; Risk Assessment; Severity of Illness Index; Survival Analysis; Ticlopidine; Treatment Outcome | 2005 |
Acute polyarthritis associated with clopidogrel treatment.
Topics: Acute Disease; Arthritis; Clopidogrel; Coronary Disease; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Myonecrosis after elective percutaneous coronary intervention: effect of clopidogrel-statin interaction.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Creatine Kinase, MB Form; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Myocardium; Necrosis; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Troponin T | 2005 |
Prior clopidogrel use and outcome of acute coronary syndrome.
Topics: Aspirin; Clopidogrel; Coronary Disease; Humans; Odds Ratio; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2006 |
Letter regarding article by Valgimigli et al, "Short- and long-term clinical outcome after drug-eluting stent implantation for the percutaneous treatment of left main coronary artery disease".
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Coronary Restenosis; Drug Implants; Humans; Platelet Aggregation Inhibitors; Radiography; Stents; Ticlopidine | 2005 |
The cost-effectiveness of dual oral antiplatelet therapy following percutaneous coronary intervention: a Swedish analysis of the CREDO trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Markov Chains; Middle Aged; Models, Econometric; Myocardial Infarction; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Stroke; Sweden; Thrombosis; Ticlopidine | 2005 |
Clopidogrel inhibits platelet-leukocyte adhesion and platelet-dependent leukocyte activation.
Topics: Animals; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Humans; Leukocytes; Male; Mice; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Reactive Oxygen Species; Stereoisomerism; Thromboplastin; Ticlopidine | 2005 |
Neutropenia associated with clopidogrel use in a patient with chronic renal failure who underwent percutaneous coronary and peripheral intervention.
Topics: Adult; Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Clopidogrel; Fatal Outcome; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Kidney Failure, Chronic; Leukocyte Count; Neutropenia; Peritoneal Dialysis; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Something old, something new: beta blockers and clopidogrel in acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Adult; Aged; China; Clopidogrel; Drug Therapy, Combination; Humans; Metoprolol; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2005 |
[Thrombotic thrombocytopenic purpura -- a rare complication associated with clopidogrel therapy. A case report].
Topics: Clopidogrel; Female; Hemolytic-Uremic Syndrome; Humans; Middle Aged; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2005 |
Interpretation of clopidogrel resistance.
Topics: Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Correction of changes in ADP-induced platelet aggregation with vasopressin analogue desglycinamide-arginine-vasopressin.
Topics: Adenosine Diphosphate; Animals; Arginine Vasopressin; Blood Platelets; Clopidogrel; Hemostasis; Hemostatics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Rats; Ticlopidine; Vasopressins | 2005 |
Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST Study.
Topics: Aged; Clopidogrel; Coronary Stenosis; Female; Humans; Male; Middle Aged; Platelet Activation; Stents; Thrombosis; Ticlopidine | 2005 |
Triple versus dual antiplatelet therapy after coronary stenting: impact on stent thrombosis.
Topics: Aspirin; Cilostazol; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Tetrazoles; Thrombosis; Ticlopidine | 2005 |
Letter regarding article by Markus et al, "Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic cardiac stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid
Topics: Aspirin; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Embolism; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Ultrasonography | 2005 |
Bleeding complications in elderly patients following acute myocardial infarction.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Warfarin | 2005 |
Clopidogrel use in children.
Topics: Adolescent; Cardiac Catheterization; Child; Child, Preschool; Clopidogrel; Drug Administration Schedule; Heart Defects, Congenital; Humans; Infant; Platelet Aggregation Inhibitors; Retrospective Studies; Thrombosis; Ticlopidine | 2005 |
Evolving role of clopidogrel in acute coronary syndromes.
Topics: Acute Disease; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2005 |
Since I started taking clopidogrel (Plavix), I've noticed small bruise marks on my body. My doctor says that I should continue taking it. Is that good advice?
Topics: Aspirin; Clopidogrel; Contusions; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Letter regarding article by Markus et al, "Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic cardiac stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid
Topics: Aspirin; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Embolism; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Ultrasonography | 2005 |
Clopidogrel induced oral ulceration.
Topics: Clopidogrel; Female; Humans; Middle Aged; Oral Ulcer; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Acquired disorders of platelet function.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bleeding Time; Blood Platelet Disorders; Blood Platelets; Clopidogrel; Hemostatics; Humans; Medical History Taking; Platelet Aggregation Inhibitors; Platelet Transfusion; Ticlopidine | 2005 |
Aspirin at low-intermediate concentrations protects retinal vessels in experimental diabetic retinopathy through non-platelet-mediated effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dinoprostone; Humans; Neurons; Platelet Aggregation Inhibitors; Rats; Retina; Retinal Vessels; Ticlopidine | 2005 |
The Retention Index Test Homburg (RTH-II): Response to clopidogrel and comparison with aggregometry and CD62P-expression.
Topics: Adenosine Diphosphate; Adult; Clopidogrel; Dose-Response Relationship, Drug; Drug Monitoring; Female; Flow Cytometry; Humans; Male; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Reference Values; Regression Analysis; Ticlopidine | 2006 |
Aspirin and clopidogrel taken until 2 days prior to coronary artery bypass graft surgery is associated with increased postoperative drainage loss.
Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Ticlopidine | 2005 |
Treatment of wide-necked intracranial aneurysms with a self-expanding stent: mid-term results.
Topics: Aneurysm, Ruptured; Clopidogrel; Follow-Up Studies; Humans; Intracranial Aneurysm; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Subarachnoid Hemorrhage; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2005 |
Design of the Dialysis Access Consortium (DAC) Clopidogrel Prevention of Early AV Fistula Thrombosis Trial.
Topics: Arteriovenous Shunt, Surgical; Aspirin; Clopidogrel; Drug Therapy, Combination; Graft Occlusion, Vascular; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Renal Dialysis; Research Design; Ticlopidine; Treatment Outcome | 2005 |
[Effects of anti-platelet drugs on myocardial no-reflow after acute myocardial infarction and reperfusion: experiment with mini-swine model].
Topics: Animals; Clopidogrel; Coronary Circulation; Myocardial Infarction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Platelet Aggregation Inhibitors; Random Allocation; Swine; Swine, Miniature; Thrombolytic Therapy; Ticlopidine; Tirofiban; Tyrosine | 2005 |
Platelet VASP phosphorylation assessment in clopidogrel-treated patients: lack of agreement between Western blot and flow cytometry.
Topics: Aged; Blood Platelets; Blotting, Western; Cell Adhesion Molecules; Clopidogrel; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Ischemia; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Protein Processing, Post-Translational; Ticlopidine | 2005 |
Case 6-2005 thoracotomy after myocardial infarction and intracoronary stenting: a balance between myocardial recovery and procedural risk.
Topics: Clopidogrel; Coronary Disease; Exercise Test; Female; Humans; Lung; Lung Neoplasms; Middle Aged; Myocardial Infarction; Oxygen Consumption; Platelet Aggregation Inhibitors; Risk; Stents; Thoracotomy; Ticlopidine | 2005 |
Optimal antiplatelet treatment for percutaneous coronary intervention: clopidogrel vs. ticlopidine.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug Interactions; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
[Drugs induced Parkinsonism: the case of a 77 year old woman].
Topics: Acetaminophen; Adenocarcinoma; Aged; Antineoplastic Agents; Clopidogrel; Female; Humans; Hypertension; Parkinsonian Disorders; Ticlopidine | 2006 |
Epidural haematoma after a combined spinal-epidural anaesthetic in a patient treated with clopidogrel and dalteparin.
Topics: Aged; Aged, 80 and over; Anesthesia, Epidural; Anesthesia, Spinal; Anticoagulants; Clopidogrel; Dalteparin; Female; Hematoma, Epidural, Spinal; Humans; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Venous thromboembolism and fractured neck of femur.
Topics: Aged; Aged, 80 and over; Anesthesia; Anticoagulants; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Female; Femoral Neck Fractures; Heparin, Low-Molecular-Weight; Humans; Incidence; Male; Patient Readmission; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Sex Distribution; Ticlopidine; Treatment Outcome; Venous Thrombosis | 2005 |
Long-term cost-effectiveness of early and sustained clopidogrel therapy for up to 1 year in patients undergoing percutaneous coronary intervention after presenting with acute coronary syndromes without ST-segment elevation.
Topics: Acute Disease; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Cost-Benefit Analysis; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Syndrome; Ticlopidine; Time Factors | 2006 |
[Short-and long-term cost-effectiveness analysis of adding clopidogrel to standard therapy in acute coronary syndrome patients in Spain].
Topics: Cardiovascular Agents; Clopidogrel; Cost-Benefit Analysis; Humans; Models, Economic; Myocardial Ischemia; Platelet Aggregation Inhibitors; Spain; Ticlopidine; Treatment Outcome | 2005 |
Treatment disparities in the care of patients with and without diabetes presenting with non-ST-segment elevation acute coronary syndromes.
Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Aspirin; Cardiac Catheterization; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Heparin; Humans; Male; Platelet Aggregation Inhibitors; Recurrence; Survival Analysis; Ticlopidine | 2006 |
[Clarification of patients at risk from the use of laminated stents].
Topics: Clopidogrel; Coronary Restenosis; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine | 2006 |
Clinical, biochemical and genetical resistance to clopidogrel in a patient with the recurrent coronary stent thrombosis--a case report and review of the literature.
Topics: Aged; Clopidogrel; Coronary Angiography; Coronary Disease; Drug Resistance; Female; Humans; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine | 2006 |
Influence of aspirin resistance on platelet function profiles in patients on long-term aspirin and clopidogrel after percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Collagen Type I; Diabetes Mellitus; Drug Resistance; Drug Therapy, Combination; Epinephrine; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Vasoconstrictor Agents | 2006 |
Drawbacks of nonrandomized trials in acute coronary syndromes.
Topics: Angina, Unstable; Cardiac Catheterization; Clinical Trials as Topic; Clopidogrel; Coronary Angiography; Data Interpretation, Statistical; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyridines; Stents; Syndrome; Ticlopidine; Time Factors | 2006 |
Management of acute coronary syndromes.
Topics: Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2005 |
Management of acute coronary syndromes.
Topics: Acute Disease; Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Follow-Up Studies; Humans; Hypolipidemic Agents; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Selection Bias; Ticlopidine | 2005 |
Prevention of carotid artery restenosis after sirolimus-coated stent implantation in pigs.
Topics: Alloys; Angioplasty, Balloon, Coronary; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Carotid Arteries; Clopidogrel; Coronary Angiography; Coronary Restenosis; Disease Models, Animal; Male; Polymers; Sirolimus; Stents; Swine; Ticlopidine; Time Factors; Ultrasonics | 2006 |
Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention: the role of dual drug resistance.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Creatine Kinase, MB Form; Drug Resistance, Multiple; Female; Humans; In Vitro Techniques; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2006 |
Different effects of tirofiban and aspirin plus clopidogrel on myocardial no-reflow in a mini-swine model of acute myocardial infarction and reperfusion.
Topics: Animals; Aspirin; Clopidogrel; Coronary Circulation; Drug Therapy, Combination; Myocardial Infarction; Myocardial Reperfusion; Nitric Oxide; Nitric Oxide Synthase; Platelet Aggregation Inhibitors; Random Allocation; Swine; Swine, Miniature; Ticlopidine; Tirofiban; Tyrosine | 2006 |
Postoperative clopidogrel improves mid-term outcome after off-pump coronary artery bypass graft surgery: a prospective study.
Topics: Aged; Anticoagulants; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Period; Prospective Studies; Recurrence; Regression Analysis; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2006 |
Variable therapeutic effectiveness of clopidogrel in acute coronary syndromes.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Premedication; Secondary Prevention; Stents; Syndrome; Ticlopidine | 2006 |
Arterial antithrombotic effects of aspirin, heparin, enoxaparin and clopidogrel alone, or in combination, in the rat.
Topics: Animals; Anticoagulants; Aspirin; Bleeding Time; Carotid Arteries; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enoxaparin; Heparin; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Thrombosis; Ticlopidine | 2006 |
Impact of adenosine diphosphate and calcium chelation on platelet aggregation testing in patients receiving clopidogrel therapy.
Topics: Adenosine Diphosphate; Amino Acid Chloromethyl Ketones; Chelating Agents; Citrates; Clopidogrel; Coronary Disease; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Sodium Citrate; Ticlopidine | 2006 |
Determination of clopidogrel resistance by whole blood platelet aggregometry and inhibitors of the P2Y12 receptor.
Topics: Adolescent; Adult; Blood Platelets; Clopidogrel; Coronary Disease; Drug Resistance; Electric Impedance; Female; Humans; Male; Membrane Proteins; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2006 |
Clopidogrel induced suppression of bovine platelet activation in vitro and a preliminary study of its effect on the development of Mannheimia haemolytica induced pneumonia.
Topics: Animals; Cattle; Clopidogrel; Male; Mannheimia haemolytica; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Pneumonia of Calves, Enzootic; Ticlopidine | 2006 |
Clopidogrel-aspirin inhibit the thrombogenicity of St. Jude mechanical aortic prostheses.
Topics: Aspirin; Clopidogrel; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Patient Selection; Platelet Aggregation Inhibitors; Postoperative Complications; Thromboembolism; Ticlopidine | 2006 |
Subarachnoid hemorrhage after lumbar puncture in a patient receiving aspirin and clopidrogel.
Topics: Anticoagulants; Aspirin; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Spinal Puncture; Subarachnoid Hemorrhage; Ticlopidine | 2006 |
Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Dipyridamole; Drug Administration Schedule; Drug Therapy, Combination; Duodenal Ulcer; Endoscopy, Gastrointestinal; Esophagitis; Female; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Hematemesis; Humans; Intestinal Mucosa; Male; Middle Aged; Platelet Aggregation Inhibitors; Stomach Ulcer; Ticlopidine; Warfarin | 2006 |
Impact of clopidogrel on suppression of circulating levels of soluble CD40 ligand in patients with unstable angina undergoing coronary stenting.
Topics: Aged; Angina, Unstable; CD40 Ligand; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Solubility; Stents; Ticlopidine | 2006 |
[Inhibition of platelet aggregation for the secondary prevention after ACS: when clopidogrel instead of ASA, when clopidogrel and ASA?].
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2006 |
Efficacy of dual antiplatelet therapy in cerebrovascular disease as demonstrated by a decline in microembolic signals. A report of eight cases.
Topics: Aged; Aspirin; Cerebrovascular Disorders; China; Clopidogrel; Drug Therapy, Combination; Embolism; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2006 |
Cost-effectiveness of the Taxus paclitaxel-eluting stent in the Swedish healthcare system.
Topics: Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Cost-Benefit Analysis; Delivery of Health Care; Drug Delivery Systems; Health Care Costs; Humans; Models, Economic; Myocardial Revascularization; Paclitaxel; Reoperation; Stents; Sweden; Taxus; Ticlopidine | 2006 |
High postclopidogrel platelet reactivity in non-ST-elevation acute coronary syndrome treated with stenting: a clue for adverse prognosis?
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Premedication; Secondary Prevention; Stents; Syndrome; Ticlopidine | 2006 |
P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation.
Topics: Adenosine Monophosphate; Animals; Blood Platelets; Butadienes; Clopidogrel; Enzyme Inhibitors; Humans; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Nitriles; Phospholipases A; Phospholipases A2; Platelet Aggregation Inhibitors; Pyrimidines; Receptor, PAR-1; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thrombin; Signal Transduction; src-Family Kinases; Thrombin; Thromboxane A2; Ticlopidine | 2006 |
Spinal cord stroke in a ballet dancer.
Topics: Accidents, Occupational; Adult; Clopidogrel; Dancing; Embolism; Female; Fibrocartilage; Humans; Intervertebral Disc; Magnetic Resonance Imaging; Paresis; Platelet Aggregation Inhibitors; Spinal Cord; Spinal Cord Ischemia; Stroke; Ticlopidine; Urinary Bladder, Neurogenic; Valsalva Maneuver | 2006 |
PHARMAC and lack of funding for clopidogrel.
Topics: Clopidogrel; Cost-Benefit Analysis; Drug Evaluation; Government Regulation; Humans; National Health Programs; New Zealand; Platelet Aggregation Inhibitors; Ticlopidine | 2005 |
Antiplatelet therapy in stroke prevention: present and future.
Topics: Aspirin; Blood Platelets; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2006 |
New modalities and aspects of antiplatelet therapy for stroke prevention.
Topics: Aspirin; Blood Platelets; Cilostazol; Clopidogrel; Drug Design; Drug Resistance; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Tetrazoles; Ticlopidine | 2006 |
Antiplatelet therapy after percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Tetrazoles; Ticlopidine; Time Factors | 2006 |
[Recommendations for peri-procedural thrombocyte aggregation inhibition].
Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Heparin; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Surgical Procedures, Operative; Thrombosis; Ticlopidine; Time Factors | 2006 |
Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents.
Topics: Aged; Angiography; Case-Control Studies; Clopidogrel; Drug Delivery Systems; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Paclitaxel; Renal Insufficiency; Sirolimus; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2006 |
PHARMAC's response on clopidogrel.
Topics: Clopidogrel; Cost-Benefit Analysis; Drug Evaluation; Government Regulation; Humans; National Health Programs; New Zealand; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Potent low dose platelet inhibitory effects of clopidogrel and aspirin on coronary thrombus formation in an animal model of acute unstable angina.
Topics: Acute Disease; Angina, Unstable; Animals; Aspirin; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Drug Therapy, Combination; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Swine; Ticlopidine | 2006 |
Molecular basis of the clinical failure of Clopidogrel therapy.
Topics: Blood Platelets; Clopidogrel; Humans; Ligands; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Failure | 2006 |
Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Diabetes Complications; Diabetes Mellitus; Female; Humans; Inflammation; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Substance Withdrawal Syndrome; Thrombosis; Ticlopidine | 2006 |
The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial.
Topics: Aspirin; Carotid Stenosis; Clopidogrel; Humans; Intracranial Embolism; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Quality Control; Randomized Controlled Trials as Topic; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2006 |
Successful lysis of coronary thrombi by long term warfarin treatment after a failed course of tirofiban infusion.
Topics: Angina Pectoris; Anticoagulants; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Enoxaparin; Female; Humans; Infusion Pumps; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Tirofiban; Treatment Failure; Treatment Outcome; Tyrosine; Warfarin | 2006 |
Comparison of ticlopidine vs. clopidogrel in addition to aspirin after paclitaxel-eluting stent implantation: insights from the TRUE (Taxusin Real-life Usage Evaluation) Study.
Topics: Aspirin; Clopidogrel; Coronary Disease; Coronary Restenosis; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Paclitaxel; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2006 |
Recurrent arterial thromboses in a woman with heparin induced thrombocytopenia, successfully managed with iloprost followed by clopidogrel. An alternative therapeutic option for heparin induced thrombocytopenia type II syndrome.
Topics: Aged; Arterial Occlusive Diseases; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Iliac Artery; Iloprost; Leg; Platelet Aggregation Inhibitors; Popliteal Artery; Radiography; Recurrence; Syndrome; Thrombocytopenia; Thrombosis; Ticlopidine; Tinzaparin | 2006 |
[The effect of paclitaxel-eluting stents on restenosis].
Topics: Animals; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Restenosis; Coronary Vessels; Disease Models, Animal; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Random Allocation; Secondary Prevention; Stents; Swine; Ticlopidine; Tunica Intima; Ultrasonography, Interventional | 2006 |
Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis.
Topics: Animals; Bleeding Time; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Eptifibatide; Fibrinolytic Agents; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Recombinant Fusion Proteins; Ticlopidine; Time Factors; Vascular Patency; von Willebrand Factor | 2006 |
The risks and safety of clopidogrel in pediatric arterial ischemic stroke.
Topics: Adolescent; Aspirin; Brain Ischemia; Child; Child, Preschool; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Hand; Headache; Hematoma, Subdural; Humans; Hypesthesia; Infant; Infant, Newborn; Moyamoya Disease; Platelet Aggregation Inhibitors; Prospective Studies; Stroke; Ticlopidine; Tomography, X-Ray Computed | 2006 |
[Can clopidogrel be responsible for neutropenia?].
Topics: Aged, 80 and over; Clopidogrel; Female; Humans; Neutropenia; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Clopidogrel and metoprolol in myocardial infarction.
Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Humans; Metoprolol; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Severity of Illness Index; Ticlopidine | 2006 |
Clopidogrel and metoprolol in myocardial infarction.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Metoprolol; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
Clopidogrel and metoprolol in myocardial infarction.
Topics: Adrenergic beta-Antagonists; Clopidogrel; Humans; Metoprolol; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Shock, Cardiogenic; Ticlopidine | 2006 |
Embedded guideline information without patient specificity in a commercial emergency department computerized order-entry system.
Topics: Adrenergic beta-Antagonists; Angina, Unstable; Aspirin; Clopidogrel; Decision Support Systems, Clinical; Emergency Service, Hospital; Fibrinolytic Agents; Guideline Adherence; Heparin; Humans; Medical Order Entry Systems; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Retrospective Studies; Risk Adjustment; Ticlopidine | 2006 |
The charisma of subgroups and the subgroups of CHARISMA.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Confidence Intervals; Data Interpretation, Statistical; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2006 |
Clopidogrel treatment prior to percutaneous coronary intervention: when enough isn't enough.
Topics: Abciximab; Angina Pectoris; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2006 |
Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cause of Death; Clopidogrel; Comorbidity; Coronary Disease; Coronary Restenosis; Coronary Stenosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Implants; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Internet; Male; Middle Aged; Myocardial Infarction; Product Surveillance, Postmarketing; Registries; Risk Factors; Sirolimus; Stents; Thrombosis; Ticlopidine; United States | 2006 |
Effect of routine clopidogrel use on bleeding complications after transbronchial biopsy in humans.
Topics: Adult; Biopsy; Bronchoscopy; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2006 |
Variability in responsiveness to clopidogrel in patients with intermittent claudication.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Intermittent Claudication; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
[Accelerated atheroma with prednisone and clopidogrel].
Topics: Aged; Atherosclerosis; Carotid Stenosis; Clopidogrel; Endarterectomy; Giant Cell Arteritis; Glucocorticoids; Humans; Inflammation; Male; Necrosis; Platelet Aggregation Inhibitors; Prednisone; Ticlopidine | 2006 |
Nickel release, a possible indicator for the duration of antiplatelet treatment, from a nickel cardiac device in vivo: a study in patients with atrial septal defects implanted with an Amplatzer occluder.
Topics: Adult; Aged; Alloys; Aspirin; Clopidogrel; Female; Heart Septal Defects, Atrial; Humans; Male; Middle Aged; Nickel; Platelet Aggregation Inhibitors; Prostheses and Implants; Ticlopidine | 2006 |
High prevalence of previous antiplatelet drug use in patients with new or recurrent ischemic stroke: Buffalo metropolitan area and Erie County stroke study.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Hospitalization; Humans; New York; Platelet Aggregation Inhibitors; Prevalence; Retrospective Studies; Risk Assessment; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2006 |
Clopidogrel loading dose (300 versus 600 mg) strategies for patients with stable angina pectoris subjected to percutaneous coronary intervention.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Retrospective Studies; Ticlopidine; Treatment Outcome | 2006 |
Effect of YM-254890, a specific Galphaq/11 inhibitor, on experimental peripheral arterial disease in rats.
Topics: Animals; Aorta; Blood Flow Velocity; Blood Pressure; Clopidogrel; Dermis; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; GTP-Binding Protein alpha Subunits, Gq-G11; Heart Rate; Hindlimb; In Vitro Techniques; Lauric Acids; Male; Peptides, Cyclic; Peripheral Vascular Diseases; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ticlopidine; Vasodilation; Vasodilator Agents | 2006 |
Effect of clopidogrel premedication in off-pump cardiac surgery: are we forfeiting the benefits of reduced hemorrhagic sequelae?
Topics: Aged; Blood Transfusion; Case-Control Studies; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Hemorrhage; Hemostasis, Surgical; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Premedication; Reoperation; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2006 |
Suspected clopidogrel resistance in a patient with acute stent thrombosis.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Drug Delivery Systems; Drug Resistance; Fibrinolytic Agents; Follow-Up Studies; Humans; Male; Prosthesis Failure; Recurrence; Risk Assessment; Stents; Ticlopidine; Treatment Outcome | 2006 |
Increased use of selective serotonin reuptake inhibitors in patients admitted with gastrointestinal haemorrhage: a multicentre retrospective analysis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Black or African American; Blood Coagulation; Case-Control Studies; Clopidogrel; Drug Interactions; Enoxaparin; Female; Gastrointestinal Hemorrhage; Hispanic or Latino; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Selective Serotonin Reuptake Inhibitors; Ticlopidine; Warfarin; White People | 2006 |
Pump-induced platelet aggregation with subsequent hypotension: Its mechanism and prevention with clopidogrel.
Topics: Adenosine Diphosphate; Albumins; Animals; Cardiopulmonary Bypass; Clopidogrel; Coated Materials, Biocompatible; Heparin; Hypotension; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stress, Mechanical; Ticlopidine | 2006 |
Combined aspirin and clopidogrel resistance associated with recurrent coronary stent thrombosis.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Restenosis; Coronary Stenosis; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Female; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine; Treatment Failure | 2006 |
[Postoperative antithrombotic treatment in diabetic patients].
Topics: Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Diabetes Mellitus; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Thrombosis; Ticlopidine; Warfarin | 2006 |
Differential antiplatelet effects of angiotensin converting enzyme inhibitors: comparison of ex vivo platelet aggregation in cardiovascular patients with ramipril, captopril and enalapril.
Topics: Adenosine Diphosphate; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Captopril; Cardiovascular Diseases; Clopidogrel; Collagen; Coronary Artery Disease; Electric Impedance; Enalapril; Female; Fibrinolytic Agents; Germany; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ramipril; Ticlopidine; Treatment Outcome | 2006 |
Platelet-derived serotonin mediates liver regeneration.
Topics: 5-Hydroxytryptophan; Amphetamines; Animals; Blood Platelets; Busulfan; Cell Proliferation; Clopidogrel; Hepatectomy; Hepatocytes; Liver; Liver Regeneration; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Count; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Thrombocytopenia; Ticlopidine; Tryptophan Hydroxylase | 2006 |
Clopidogrel to treat patients with non-ST-segment elevation acute coronary syndromes after hospital discharge.
Topics: Aged; Angina, Unstable; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Syndrome; Ticlopidine | 2006 |
Basilar artery dolichoectasia with partial thrombosis.
Topics: Aged; Anticholesteremic Agents; Clopidogrel; Humans; Magnetic Resonance Imaging; Male; Platelet Aggregation Inhibitors; Pravastatin; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Vertebrobasilar Insufficiency | 2006 |
Short term palindromic rheumatism after clopidogrel use.
Topics: Clopidogrel; Drug Eruptions; Female; Humans; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Rheumatic Diseases; Ticlopidine | 2006 |
Images in cardiology. Unexpected response of saphenous vein graft occlusion to antiplatelet drugs.
Topics: Aged; Aspirin; Clopidogrel; Graft Occlusion, Vascular; Humans; Male; Platelet Aggregation Inhibitors; Saphenous Vein; Ticlopidine | 2006 |
Clopidogrel (Plavix) revisited.
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2006 |
[Emergency measures in acute arterial occlusion. Why there are still colleagues who do it incorrectly?].
Topics: Acute Disease; Angiography; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Embolism; Emergencies; Heparin; Humans; Injections, Intravenous; Leg; Male; Platelet Aggregation Inhibitors; Thromboangiitis Obliterans; Ticlopidine; Ulnar Artery | 2006 |
P2Y1 gene A1622G dimorphism is not associated with adenosine diphosphate-induced platelet activation and aggregation after administration of a single high dose of clopidogrel.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Female; Genotype; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Ticlopidine | 2006 |
Quantification of clopidogrel in human plasma by sensitive liquid chromatography/tandem mass spectrometry.
Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Clopidogrel; Humans; Indicators and Reagents; Linear Models; Platelet Aggregation Inhibitors; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Therapeutic Equivalency; Ticlopidine | 2006 |
Pulmonary thromboembolism.
Topics: Animals; Cat Diseases; Cats; Clopidogrel; Diagnosis, Differential; Female; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Platelet Aggregation Inhibitors; Pulmonary Embolism; Radiography, Thoracic; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2006 |
Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel.
Topics: Adenine; Alleles; Anticoagulants; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Coronary Artery Disease; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Genetic Variation; Genotype; Guanine; Humans; Introns; Liver; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Ticlopidine | 2006 |
[More modest use in secondary prevention, risky in primary prevention].
Topics: Arteriosclerosis; Aspirin; Cause of Death; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Humans; Intracranial Embolism; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Survival Rate; Ticlopidine | 2006 |
Concurrent use of clopidogrel (Plavix) and atorvasatin (Lipitor) is contraindicated.
Topics: Atorvastatin; Clopidogrel; Contraindications; Coronary Disease; Drug Incompatibility; Drug Therapy, Combination; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2006 |
[Haemostasis and antithrombotic drugs: pharmacology and novel therapeutic approaches].
Topics: Anticoagulants; Clopidogrel; Hemostasis; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Correlation of a new point-of-care test with conventional optical aggregometry for the assessment of clopidogrel responsiveness.
Topics: Clopidogrel; Drug Monitoring; Humans; Nephelometry and Turbidimetry; Platelet Aggregation; Point-of-Care Systems; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2006 |
[Thrombosis of a coronary stent after discontinuing treatment with clopidogrel].
Topics: Adult; Aged; Angina Pectoris; Aspirin; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2006 |
Clopidogrel reduces the development of transplant arteriosclerosis.
Topics: Animals; Aorta; Arteriosclerosis; Clopidogrel; Disease Models, Animal; Graft Rejection; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Platelet Aggregation Inhibitors; Ticlopidine; Transplantation, Homologous | 2006 |
[Optimisation of the myocardial infarction pharmacotherapy--important insights from the COMMIT Trial].
Topics: Antihypertensive Agents; Clopidogrel; Humans; Metoprolol; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
Growth in clopidogrel-aspirin combination therapy.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Data Collection; Drug Therapy, Combination; Drug Utilization; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; United States | 2006 |
Rash with both clopidogrel and ticlopidine in two patients following percutaneous coronary intervention with drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Cardiomyopathy, Dilated; Clopidogrel; Coronary Artery Bypass; Coronary Restenosis; Diabetes Mellitus, Type 2; Drug Eruptions; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Poliomyelitis; Stents; Ticlopidine | 2006 |
Catheter thrombosis during primary percutaneous coronary intervention for acute ST elevation myocardial infarction despite subcutaneous low-molecular-weight heparin, acetylsalicylic acid, clopidogrel and abciximab pretreatment.
Topics: Abciximab; Adult; Aged; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Anticoagulants; Aspirin; Cardiac Catheterization; Clopidogrel; Enoxaparin; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombolytic Therapy; Thrombosis; Ticlopidine | 2006 |
Clopidogrel resistance caused by a failure to metabolize clopidogrel into its metabolites.
Topics: Adult; Area Under Curve; Chromatography, Liquid; Clopidogrel; Drug Resistance; Female; Humans; Mass Spectrometry; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Comment: mortality benefit of no-load clopidogrel in COMMIT: not a surprise.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Can the PFA-100 be modified to detect P2Y12 inhibition?
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Clopidogrel; Drug Monitoring; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Ticlopidine | 2006 |
Simultaneous, painless, homolateral oculomotor and trochlear nerve palsies in a patient with type 2 diabetes mellitus. Neuropathy or brainstem infarction?
Topics: Aged; Cerebral Infarction; Clopidogrel; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Neuropathies; Diagnosis, Differential; Female; Humans; Hyperlipidemias; Hypertension; Insulin; Magnetic Resonance Imaging; Paralysis; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2006 |
[Even in 60-year-old atrial fibrillation is not uncommon. Advances in long-term treatment].
Topics: Administration, Oral; Age Factors; Anti-Arrhythmia Agents; Anticoagulants; Aspirin; Atrial Fibrillation; Catheter Ablation; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Germany; Humans; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Registries; Risk Factors; Thromboembolism; Ticlopidine; Vitamin K | 2006 |
Antithrombotic therapy in heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Clopidogrel; Drug Interactions; Heart Failure; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thromboembolism; Ticlopidine; Warfarin | 2006 |
Late in-stent thrombosis following carotid angioplasty and stenting.
Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Anticoagulants; Aphasia; Aspirin; Basal Ganglia; Calcinosis; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Hematuria; Heparin; Humans; Infarction, Middle Cerebral Artery; Male; Mouth Neoplasms; Neck Dissection; Neoplasm Recurrence, Local; Paresis; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Ultrasonography; Urinary Bladder Neoplasms; Vertigo | 2006 |
[Drug-releasing stents. Little use in cardiology despite excellent data--what next?].
Topics: Aspirin; Clopidogrel; Delayed-Action Preparations; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2006 |
Lupus anticoagulant and ischemic myocardial microangiopathy in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Clopidogrel; Echocardiography; Humans; Interleukin 1 Receptor Antagonist Protein; Lupus Coagulation Inhibitor; Male; Methotrexate; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prednisolone; Radionuclide Imaging; Sialoglycoproteins; Ticlopidine | 2006 |
Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Severity of Illness Index; Stents; Ticlopidine; Warfarin | 2006 |
Clopidogrel desensitization.
Topics: Aged; Angioplasty; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Desensitization, Immunologic; Humans; Male; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Urticaria | 2006 |
Aspirin and clopidogrel resistance: an emerging clinical entity.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
[Clopidogrel and aspirin versus aspirin alone in prevention of atherothrombotic events. The results of CHARISMA study].
Topics: Aged; Arteriosclerosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Severity of Illness Index; Thrombosis; Ticlopidine; Treatment Outcome | 2006 |
Understanding clopidogrel efficacy in the presence of cytochrome P450 polymorphism.
Topics: Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Embolism, Cholesterol; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Thrombosis; Ticlopidine | 2006 |
A case of fatal stent thrombosis after Carbostent implantation: is clopidogrel alone antiplatelet therapy a safe alternative to aspirin alone antiplatelet therapy?
Topics: Aged; Aspirin; Clopidogrel; Fatal Outcome; Humans; Male; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
Good old warfarin for stroke prevention in atrial fibrillation.
Topics: Anticoagulants; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; Warfarin | 2006 |
Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registry.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Cardiovascular Agents; Cause of Death; Clopidogrel; Combined Modality Therapy; Coronary Restenosis; Drug Administration Schedule; Drug Implants; Female; Follow-Up Studies; Hospitalization; Humans; Life Tables; Male; Middle Aged; Mortality; Myocardial Infarction; Patient Education as Topic; Platelet Aggregation Inhibitors; Prevalence; Proportional Hazards Models; Prospective Studies; Pyridines; Registries; Sirolimus; Stents; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome; Treatment Refusal | 2006 |
Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects.
Topics: Adolescent; Adult; Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Homozygote; Humans; Male; Mixed Function Oxygenases; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Ticlopidine | 2006 |
Spontaneous or clopidogrel related recanalisation of a coronary artery.
Topics: Clopidogrel; Coronary Angiography; Coronary Stenosis; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Late in-stent thrombosis in a patient with systemic lupus erythematosus and hyperhomocysteinemia while on clopidogrel and aspirin.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Coagulation Disorders; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Female; Humans; Hyperhomocysteinemia; Lupus Erythematosus, Systemic; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors | 2006 |
Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Clopidogrel; Coronary Artery Disease; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Signal Transduction; Thrombosis; Thromboxane B2; Ticlopidine; Time Factors; Treatment Refusal | 2006 |
Plavix isn't for everyone. Adding Plavix to aspirin doesn't help people without heart disease.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2006 |
Use of whole blood platelet lumi-aggregometry to optimize anti-platelet therapy in patients with chronic myeloproliferative disorders.
Topics: Aspirin; Chronic Disease; Clopidogrel; Dietary Supplements; Dose-Response Relationship, Drug; Garlic; Humans; Luminescent Measurements; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2006 |
Antiplatelet therapy prior to carotid endarterectomy--still room for improvement.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Austria; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Drug Utilization; Endarterectomy, Carotid; Female; Guideline Adherence; Health Care Surveys; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Premedication; Stroke; Ticlopidine | 2006 |
Prasugrel, clopidogrel, and combining Swedish apples with American oranges.
Topics: Clinical Trials, Phase II as Topic; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2006 |
Reversible ageusia associated with clopidogrel treatment.
Topics: Ageusia; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Clopidogrel-associated thrombotic thrombocytopenic purpura presenting with coronary artery thrombosis.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Female; Humans; L-Lactate Dehydrogenase; Plasmapheresis; Platelet Aggregation Inhibitors; Platelet Count; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2006 |
Enhanced platelet activation by prolactin in patients with ischemic stroke.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Leptin; Male; Middle Aged; P-Selectin; Platelet Activation; Prolactin; Retrospective Studies; Risk Factors; Stroke; Thrombophilia; Ticlopidine | 2006 |
[Recurrent hemoptysis following thienopyridines and amiodarone administration. therapeutic dilemma].
Topics: Aged; Amiodarone; Cardiovascular Agents; Clopidogrel; Coronary Disease; Drug Interactions; Drug Therapy, Combination; Hemoptysis; Humans; Male; Platelet Aggregation Inhibitors; Pyridines; Recurrence; Ticlopidine | 2005 |
Chest pain in a young basketball player.
Topics: Accidental Falls; Adult; Basketball; Chest Pain; Clopidogrel; Coronary Angiography; Electrocardiography; Heart Block; Humans; Male; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2006 |
Sub-Tenon's anesthesia with aspirin, warfarin, and clopidogrel.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anticoagulants; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Conjunctival Diseases; Connective Tissue; Eye Hemorrhage; Female; Humans; Lens Implantation, Intraocular; Male; Medical Audit; Middle Aged; Phacoemulsification; Prospective Studies; Risk Factors; Ticlopidine; Warfarin | 2006 |
Use of ticlopidine and cilostazol after intracoronary drug-eluting stent placement in a patient with previous clopidogrel-induced thrombotic thrombocytopenic purpura: a case report.
Topics: ADAM Proteins; ADAMTS1 Protein; Aged; Apoptosis; Aspirin; Autoantibodies; Cilostazol; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Coronary Thrombosis; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Plasmapheresis; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Stents; Tetrazoles; Ticlopidine | 2006 |
An alternative treatment strategy for pump thrombus in the DeBakey VAD Child: use of clopidogrel as a thrombolytic agent.
Topics: Adolescent; Aspirin; Cardiomyopathy, Dilated; Clopidogrel; Equipment Failure; Fibrinolytic Agents; Heart Transplantation; Heart-Assist Devices; Humans; Male; Thrombosis; Ticlopidine; Warfarin | 2006 |
Carotid stenting.
Topics: Aged; Aspirin; Cardiovascular Agents; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine | 2006 |
Medical management of peripheral arterial disease.
Topics: Aspirin; Clopidogrel; Cost-Benefit Analysis; Humans; Peripheral Vascular Diseases; Phthalic Acids; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Spontaneous abdominal hematoma in a patient treated with clopidogrel and aspirin.
Topics: Abdominal Cavity; Abdominal Pain; Aged; Aspirin; Clopidogrel; Hematoma; Humans; Kidney Diseases; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
[Gastroenterology in family practice. Updates for your "stomach patient"].
Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Dyspepsia; Esophagitis, Peptic; Family Practice; Heartburn; Helicobacter Infections; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Ticlopidine | 2006 |
The obesity paradox in non-ST-segment elevation acute coronary syndromes: results from the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the American College of Cardiology/American Heart A
Topics: Aged; Angina, Unstable; Body Mass Index; Clopidogrel; Female; Guideline Adherence; Humans; Hypolipidemic Agents; Male; Middle Aged; Myocardial Infarction; Obesity; Odds Ratio; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Quality of Health Care; Risk Assessment; Risk Factors; Survival Analysis; Syndrome; Ticlopidine; Treatment Outcome; United States | 2006 |
[Bilateral hemothorax secondary to combined antiplatelet therapy with clopidogrel and acetylsalicylic acid].
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemothorax; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Epidural haematoma.
Topics: Anesthesia; Anesthesia, Epidural; Anesthesia, Spinal; Anticoagulants; Clopidogrel; Dalteparin; Hematoma, Epidural, Spinal; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts.
Topics: Adenosine Diphosphate; Animals; Cell Line; Chlorocebus aethiops; Clopidogrel; Humans; Membrane Microdomains; Mutation; Protein Binding; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2006 |
Aspirin and clopidogrel resistance.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Resistance, Multiple; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2006 |
Unveiling the inflammatory face of antiplatelet drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Humans; Inflammation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Up-Regulation | 2006 |
More on: enhanced antiplatelet effect of clopidogrel in patients whose platelets are least inhibited by aspirin: a randomized cross-over trial.
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
Spontaneous retroperitoneal haematoma associated with clopidogrel therapy mimicking acute appendicitis.
Topics: Abdominal Pain; Acute Disease; Appendicitis; Clopidogrel; Diagnosis, Differential; Hematoma; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retroperitoneal Space; Ticlopidine | 2006 |
Acute clopidogrel use and outcomes in patients with non-ST-segment elevation acute coronary syndromes undergoing coronary artery bypass surgery.
Topics: Aged; Angina, Unstable; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Guideline Adherence; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Retrospective Studies; Syndrome; Ticlopidine; Time Factors; Treatment Outcome | 2006 |
Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment.
Topics: Aged; Aspirin; Clopidogrel; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2006 |
CHARISMA: the antiplatelet saga continues.
Topics: Atherosclerosis; Clinical Trials as Topic; Clopidogrel; Humans; Ischemia; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Failure | 2006 |
[Combination of clopidogrel and aspirin was no better than aspirin alone for prevention of atherothrombotic events in stable patients. Results of CHARISMA].
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Severity of Illness Index; Ticlopidine; Treatment Outcome | 2006 |
Concurrent use of clopidogrel (Plavix) and atorvastatin (Lipitor) is contraindicated.
Topics: Atorvastatin; Clopidogrel; Contraindications; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Antagonism; Drug Synergism; Drug Therapy, Combination; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2006 |
Clinical, biochemical and genetical resistance to clopidogrel in a patient with recurrent stent thrombosis.
Topics: Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine | 2007 |
A study comparing the incidence and predictors of creatine kinase MB and troponin T release after coronary angioplasty. Does Clopidogrel preloading reduce myocardial necrosis following elective percutaneous coronary intervention?
Topics: Angioplasty, Balloon, Coronary; Biomarkers; Clopidogrel; Cohort Studies; Coronary Disease; Creatine Kinase, MB Form; Elective Surgical Procedures; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Myocardium; Necrosis; Platelet Aggregation Inhibitors; Preoperative Care; Sensitivity and Specificity; Ticlopidine; Troponin T; United Kingdom | 2007 |
Clopidogrel for the prevention of atherothrombotic events.
Topics: Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2006 |
Clopidogrel for the prevention of atherothrombotic events.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Data Interpretation, Statistical; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Research Design; Ticlopidine | 2006 |
Clopidogrel for the prevention of atherothrombotic events.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Clopidogrel for the prevention of atherothrombotic events.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Incidence; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Clopidogrel for the prevention of atherothrombotic events.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2006 |
Clopidogrel-statin interaction: a mountain or a mole hill?
Topics: Atorvastatin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Pravastatin; Pyrroles; Ticlopidine | 2006 |
A pharmacoepidemiology study of the interaction between atorvastatin and clopidogrel after percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Atorvastatin; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Heptanoic Acids; Humans; Logistic Models; Male; Middle Aged; Pharmacoepidemiology; Platelet Aggregation Inhibitors; Pyrroles; Quebec; Retrospective Studies; Stents; Ticlopidine | 2006 |
Clopidogrel-induced hepatotoxicity and fever.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Fever; Humans; Liver Function Tests; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Long-term clinical outcome of patients treated with beta-brachytherapy in routine clinical practice.
Topics: Aspirin; Brachytherapy; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Effect of clopidogrel on nitric oxide levels in an ischemia reperfusion model.
Topics: Animals; Clopidogrel; Disease Models, Animal; Intubation, Gastrointestinal; Liver; Lung; Muscle, Skeletal; Nitric Oxide; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ticlopidine | 2006 |
Epidural haematoma.
Topics: Anesthesia; Anesthesia, Epidural; Anesthesia, Spinal; Clopidogrel; Hematoma, Epidural, Spinal; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin.
Topics: Aged; Angioplasty; Aryl Hydrocarbon Hydroxylases; Aspirin; Cell Adhesion Molecules; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Drug Antagonism; Enzyme Inhibitors; Female; Humans; Male; Microfilament Proteins; Mixed Function Oxygenases; Omeprazole; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Protein Processing, Post-Translational; Thrombosis; Ticlopidine | 2006 |
Viscosity, hemostasis and inflammation in atherosclerotic heart diseases.
Topics: Aged; Aspirin; Blood Viscosity; Brain Ischemia; Clopidogrel; Coronary Artery Disease; Diabetes Complications; Female; Glucose; Glycated Hemoglobin; Hemostasis; Humans; Inflammation; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; von Willebrand Factor | 2006 |
Cyclooxygenase-2 inhibitors enhance shear stress-induced platelet aggregation.
Topics: Animals; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Stenosis; Cyclooxygenase Inhibitors; Isoxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Risk Factors; Shear Strength; Thrombosis; Ticlopidine | 2006 |
Clopidogrel reduces platelet-leucocyte aggregation, monocyte activation and RANTES secretion in type 2 diabetes mellitus.
Topics: Chemokine CCL5; Clopidogrel; Diabetes Mellitus, Type 2; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Suberythrodermic pustular psoriasis induced by clopidogrel.
Topics: Aged; Clopidogrel; Drug Eruptions; Female; Humans; Platelet Aggregation Inhibitors; Psoriasis; Ticlopidine | 2006 |
Aspirin still best for clot prevention.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
Non-bleeding side effects of clopidogrel: have large multi-center clinical trials underestimated their incidence?
Topics: Clinical Trials as Topic; Clopidogrel; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
COMMIT/CCS-2 studies.
Topics: Adrenergic beta-Antagonists; Clopidogrel; Humans; Metoprolol; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
Posterior compartment syndrome associated with clopidogrel therapy following trivial trauma.
Topics: Accidental Falls; Aged, 80 and over; Clopidogrel; Compartment Syndromes; Humans; Leg Injuries; Male; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2006 |
Iliac anastomotic stenting with a biodegradable poly-L-lactide stent: a preliminary study after 1 and 6 weeks.
Topics: Absorbable Implants; Anastomosis, Surgical; Animals; Arteritis; Aspirin; Clopidogrel; Feasibility Studies; Female; Iliac Artery; Laser-Doppler Flowmetry; Pilot Projects; Platelet Aggregation Inhibitors; Polyesters; Stents; Swine; Thrombosis; Ticlopidine; Tunica Intima; Ultrasonography | 2006 |
Impact of PlA polymorphism of platelet GP IIb/IIIa receptors on clinical course during long-term LVAD support is independent of type of LVAD.
Topics: Anticoagulants; Antigens, Human Platelet; Aspirin; Clopidogrel; Equipment Design; Genetic Predisposition to Disease; Genotype; Heart-Assist Devices; Hemorrhagic Disorders; Humans; Incidence; Integrin beta3; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Postoperative Complications; Thromboembolism; Thrombophilia; Ticlopidine | 2006 |
Response to aspirin and clopidogrel monitored with different platelet function methods.
Topics: Aged; Arterial Occlusive Diseases; Aspirin; Automation; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2006 |
Surgical revascularisation in patients with severe limb ischaemia induces a pro-thrombotic state.
Topics: Aged; Aged, 80 and over; Antithrombin III; Arterial Occlusive Diseases; Aspirin; Blood Coagulation; Clopidogrel; Female; Fibrin Fibrinogen Degradation Products; Humans; Ischemia; Male; P-Selectin; Peptide Hydrolases; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Reperfusion; Thrombosis; Ticlopidine; Vascular Surgical Procedures; von Willebrand Factor | 2006 |
Clinical policy: critical issues in the evaluation and management of adult patients with non-ST-segment elevation acute coronary syndromes.
Topics: Adult; Angina Pectoris; Biomarkers; Cardiology; Clopidogrel; Electrocardiography; Emergency Service, Hospital; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2006 |
[Physicians and insurance may collaborate on therapy].
Topics: Aspirin; Clopidogrel; Contract Services; Cooperative Behavior; Cost-Benefit Analysis; Drug Costs; Family Practice; Germany; Humans; Interprofessional Relations; Myocardial Infarction; National Health Programs; Physician's Role; Stroke; Ticlopidine | 2006 |
A head-to-head comparison between the VerifyNow P2Y12 assay and light transmittance aggregometry for monitoring the individual platelet response to clopidogrel in patients undergoing elective percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug Monitoring; Elective Surgical Procedures; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Reagent Kits, Diagnostic; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Reproducibility of Results; Stents; Ticlopidine | 2006 |
Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol.
Topics: Animals; Aspirin; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cell Survival; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Clopidogrel; Esters; Ethanol; Humans; Hydrolysis; In Vitro Techniques; Intestinal Mucosa; Microsomes; Microsomes, Liver; Mutagenesis, Site-Directed; Platelet Aggregation Inhibitors; Rats; Ticlopidine; Transfection | 2006 |
Usefulness of clopidogrel in abolishing the increased risk of reinfarction associated with higher platelet counts in patients with ST-elevation myocardial infarction (results from CLARITY-TIMI 28).
Topics: Aged; Clopidogrel; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Count; Randomized Controlled Trials as Topic; Recurrence; Ticlopidine | 2006 |
End-stage renal disease and drug-eluting stents: one small step forward.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Coronary Restenosis; Humans; Infusion Pumps, Implantable; Kidney Failure, Chronic; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prevalence; Renal Dialysis; Stents; Ticlopidine; Treatment Outcome | 2006 |
Role of the P2Y12 gene polymorphism in platelet responsiveness to clopidogrel in healthy subjects.
Topics: Adolescent; Adult; Clopidogrel; Humans; Pharmacogenetics; Platelet Aggregation; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2006 |
Successful percutaneous coronary intervention using bivalirudin in a patient with chronic lymphocytic leukemia and thrombocytopenia.
Topics: Aged; Cardiac Catheterization; Clopidogrel; Hirudins; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Peptide Fragments; Recombinant Proteins; Thrombocytopenia; Ticlopidine | 2006 |
Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel.
Topics: Antiviral Agents; Carboxylic Ester Hydrolases; Cell Line; Cell Survival; Clopidogrel; Drug Interactions; Humans; Hydrolysis; Mass Spectrometry; Microsomes; Mutagenesis, Site-Directed; Oseltamivir; Platelet Aggregation Inhibitors; Ticlopidine; Transfection | 2006 |
Tackling the diabetic platelet: is high clopidogrel dosing the answer?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Diabetes Mellitus, Type 2; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2006 |
Validated HPLC method for determination of carboxylic acid metabolite of clopidogrel in human plasma and its application to a pharmacokinetic study.
Topics: Adult; Carboxylic Acids; Chromatography, High Pressure Liquid; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine | 2006 |
[When ASS, when anticoagulants?].
Topics: Administration, Oral; Age Factors; Aged; Anticoagulants; Aspirin; Clopidogrel; Female; Heart Diseases; Heparin, Low-Molecular-Weight; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Primary Prevention; Risk Factors; Sex Factors; Stroke; Ticlopidine; Time Factors | 2006 |
[Cost-effectiveness of clopidogrel vs. aspirin treatment in high-risk acute coronary syndrome patients in Denmark].
Topics: Acute Disease; Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Cost-Benefit Analysis; Humans; Ischemia; Leg; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Syndrome; Ticlopidine | 2006 |
Plasma levels of the growth arrest-specific gene 6 product (Gas6) and antiplatelet drug responsiveness in healthy subjects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Humans; Intercellular Signaling Peptides and Proteins; Mice; Odds Ratio; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Regression Analysis; Risk; Ticlopidine | 2006 |
[Prevention of vascular events after transient ischemic attack or cerebral infarct].
Topics: Angioplasty, Balloon; Anticoagulants; Aspirin; Cerebral Infarction; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Hypolipidemic Agents; Ischemic Attack, Transient; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Stents; Stroke; Ticlopidine; Time Factors; Warfarin | 2006 |
Platelet function in patients with acute coronary syndrome (ACS) predicts recurrent ACS.
Topics: Acute Disease; Adrenergic beta-Antagonists; Aspirin; Clopidogrel; Coronary Disease; Diabetes Complications; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Odds Ratio; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Recurrence; Research Design; Risk Assessment; Stress, Mechanical; Syndrome; Ticlopidine; Time Factors; von Willebrand Factor | 2006 |
Delaying generic competition--corporate payoffs and the future of Plavix.
Topics: Clopidogrel; Drug Industry; Drugs, Generic; Economic Competition; Humans; Legislation, Drug; Patents as Topic; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; United States; United States Federal Trade Commission | 2006 |
Biosignatures in thrombotic disorders.
Topics: Aspirin; Biomarkers; Clopidogrel; Drug Therapy, Combination; Gene Expression Profiling; Humans; Patient Selection; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk Factors; Thrombosis; Ticlopidine | 2006 |
Antiplatelet and anticoagulant therapy in patients with giant cell arteritis.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Brain Ischemia; Clopidogrel; Cohort Studies; Dose-Response Relationship, Drug; Female; Giant Cell Arteritis; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stroke; Ticlopidine; Warfarin | 2006 |
Aspirin and clopidogrel resistance in patients with diabetes mellitus.
Topics: Aspirin; Clopidogrel; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
[Bleeding complications after treatment with antithrombotic agents after acute coronary syndrome].
Topics: Acute Disease; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 2006 |
[Bleeding complications after treatment with clopidogrel and acetylsalicylic acid after acute coronary syndrome].
Topics: Age Factors; Aged; Angina, Unstable; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Fibrinolytic Agents; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Thrombolytic Therapy; Ticlopidine | 2006 |
Recent trends in the care of patients with non-ST-segment elevation acute coronary syndromes: insights from the CRUSADE initiative.
Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Cardiac Catheterization; Clopidogrel; Coronary Artery Bypass; Counseling; Drug Utilization; Female; Guideline Adherence; Heparin; Humans; Hypolipidemic Agents; Life Style; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Quality Assurance, Health Care; Smoking Cessation; Ticlopidine; United States | 2006 |
[Heart catheter in angina pectoris: must we set stricter indications?].
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Cardiac Catheterization; Clopidogrel; Exercise; Follow-Up Studies; Humans; Patient Selection; Platelet Aggregation Inhibitors; Prognosis; Quality of Life; Stents; Ticlopidine; Time Factors | 2006 |
Clopidogrel (PLAVIX) increases risk of bleeding in a patient undergoing coronary artery bypass grafting.
Topics: Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Assessment; Risk Factors; Ticlopidine | 2006 |
Effect of clopidogrel on 1-year mortality in hospital survivors of acute ST-segment elevation myocardial infarction in clinical practice.
Topics: Aged; Clopidogrel; Female; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Ticlopidine | 2006 |
Case report: An unusual complication of clopidogrel.
Topics: Clopidogrel; Coronary Stenosis; Hallucinations; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
The CHARISMA trial and the REACH registry outcomes.
Topics: Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Humans; Incidence; Platelet Aggregation Inhibitors; Registries; Risk Factors; Ticlopidine; Treatment Outcome | 2006 |
Effectiveness and safety of glycoprotein IIb/IIIa inhibitors and clopidogrel alone and in combination in non-ST-segment elevation myocardial infarction (from the National Registry of Myocardial Infarction-4).
Topics: Aged; Aged, 80 and over; Analysis of Variance; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Cross-Sectional Studies; Drug Therapy, Combination; Endpoint Determination; Female; Heart Conduction System; Hemorrhage; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recurrence; Registries; Ticlopidine; Treatment Outcome; United States | 2006 |
Calcified occlusion of the right coronary artery in Kawasaki disease: evidence of myocardial ischaemia using cardiac technetium-99m-tetrofosmin perfusion single-photon emission computed tomography.
Topics: Adolescent; Calcification, Physiologic; Clopidogrel; Coronary Vessels; Echocardiography, Stress; Exercise Test; Humans; Male; Mucocutaneous Lymph Node Syndrome; Myocardial Ischemia; Organophosphorus Compounds; Organotechnetium Compounds; Platelet Aggregation Inhibitors; Radiopharmaceuticals; Ticlopidine; Tomography, Emission-Computed, Single-Photon; Ventricular Outflow Obstruction | 2006 |
Effect of clopidogrel on midterm graft patency following off-pump coronary revascularization surgery.
Topics: Clopidogrel; Cohort Studies; Coronary Artery Bypass, Off-Pump; Female; Graft Occlusion, Vascular; Graft Survival; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome; Vascular Patency | 2006 |
Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Follow-Up Studies; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Treatment Outcome | 2006 |
[Antiplatelet therapy after aspirin-induced upper gastrointestinal bleeding].
Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Esomeprazole; Evidence-Based Medicine; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Ticlopidine | 2006 |
Late thrombosis of drug-eluting stents after discontinuation of clopidogrel: report of two cases and review of the literature.
Topics: Aged, 80 and over; Aspirin; Clopidogrel; Coronary Thrombosis; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Radiography; Stents; Thrombosis; Ticlopidine; Time Factors; Ultrasonography | 2006 |
[Beneficial effect of a loading dose of 600 mg of clopidogrel on platelet parameters in patients admitted for acute coronary syndrome].
Topics: Acute Disease; Angina, Unstable; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2006 |
Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6.
Topics: Algorithms; Alkynes; Antidepressive Agents, Second-Generation; Antifungal Agents; Area Under Curve; Benzoxazines; Bupropion; Clopidogrel; Clotrimazole; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Itraconazole; Kinetics; Microsomes, Liver; Molecular Structure; Oxazines; Platelet Aggregation Inhibitors; Raloxifene Hydrochloride; Reverse Transcriptase Inhibitors; Selective Estrogen Receptor Modulators; Selective Serotonin Reuptake Inhibitors; Sertraline; Ticlopidine; Xenobiotics | 2006 |
Letter by van der Linden et al regarding article, "Effect of clopidogrel premedication in off-pump cardiac surgery: are we forfeiting the benefits of reduced hemorrhagic sequelae?".
Topics: Aprotinin; Clopidogrel; Coronary Artery Bypass, Off-Pump; Hemorrhage; Hemostatics; Humans; Platelet Aggregation Inhibitors; Premedication; Ticlopidine | 2006 |
Letter by Poston regarding article, "Effect of clopidogrel premedication in off-pump cardiac surgery: are we forfeiting the benefits of reduced hemorrhagic sequelae?".
Topics: Clopidogrel; Coronary Artery Bypass, Off-Pump; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Premedication; Ticlopidine | 2006 |
Clopidogrel in patients with acute coronary syndromes: learning from clinical practice.
Topics: Aged; Angina, Unstable; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Retrospective Studies; Syndrome; Ticlopidine | 2006 |
Premature discontinuation of antiplatelet therapy in patients with drug-eluting coronary stents.
Topics: Aspirin; Clopidogrel; Coronary Restenosis; Coronary Vessels; Delayed-Action Preparations; Humans; Paclitaxel; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Sirolimus; Stents; Ticlopidine | 2006 |
Late angiographic stent thrombosis in a drug-eluting stent that occurred 20 months after premature discontinuation of clopidogrel administration.
Topics: Adult; Clopidogrel; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Humans; Male; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine | 2006 |
A cost analysis in patients with acute coronary syndrome using clopidogrel in addition to aspirin in a Hong Kong public hospital.
Topics: Aged; Aspirin; Clopidogrel; Coronary Disease; Costs and Cost Analysis; Female; Hong Kong; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Syndrome; Ticlopidine | 2006 |
Nontraumatic spinal epidural hematoma associated with clopidogrel.
Topics: Aged; Back Pain; Clopidogrel; Female; Hematoma, Epidural, Spinal; Humans; Hypertension; Magnetic Resonance Imaging; Myocardial Infarction; Paraplegia; Platelet Aggregation Inhibitors; Spine; Stroke; Ticlopidine; Urinary Incontinence | 2006 |
Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding Sites; Clopidogrel; Computational Biology; Computer Simulation; Humans; In Vitro Techniques; Indicators and Reagents; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Platelet Aggregation Inhibitors; Protein Conformation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Rhodopsin; Sequence Homology, Amino Acid; Thermodynamics; Ticlopidine | 2007 |
Role of antiplatelets in carotid artery stenting.
Topics: Angioplasty, Balloon; Aspirin; Carotid Stenosis; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Eptifibatide; Humans; Peptides; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine | 2007 |
[The CHARISMA study: in search of the best antiplatelet strategy for cardiovascular prevention].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Prospective Studies; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
A current problem in cardiology: very late thrombosis after implantation of sirolimus eluting stent.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Humans; Immunosuppressive Agents; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Sirolimus; Ticlopidine; Time Factors | 2007 |
Successful management of patients with a drug-eluting coronary stent presenting for elective, non-cardiac surgery.
Topics: Aged; Clopidogrel; Coated Materials, Biocompatible; Coronary Restenosis; Drug Administration Schedule; Drug Delivery Systems; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Paclitaxel; Perioperative Care; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
Effect of clopidogrel plus aspirin on ST segments in patients with ST-elevation acute myocardial infarction.
Topics: Aspirin; Clopidogrel; Electrocardiography; Female; Fibrinolytic Agents; Humans; Length of Stay; Logistic Models; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke Volume; Ticlopidine | 2006 |
Effectiveness of same day percutaneous coronary intervention followed by minimally invasive aortic valve replacement for aortic stenosis and moderate coronary disease ("hybrid approach").
Topics: Aged; Aged, 80 and over; Aortic Valve; Aortic Valve Stenosis; Aspirin; Clopidogrel; Coronary Disease; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Minimally Invasive Surgical Procedures; Prospective Studies; Stents; Ticlopidine | 2006 |
Clopidogrel response variability and future therapies: clopidogrel: does one size fit all?
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Chest Pain; Clopidogrel; Coronary Angiography; Electrocardiography; Female; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine; Treatment Outcome | 2006 |
The platelet inhibiting effect of a clopidogrel bolus dose in patients on long-term acetylsalicylic acid treatment.
Topics: Aged; Aspirin; Blood Coagulation Tests; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fibrinogen; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation Inhibitors; Protein Binding; Reference Values; Thrombelastography; Ticlopidine; Time Factors | 2007 |
Clopidogrel (Plavix) desensitization protocol.
Topics: Aged; Clopidogrel; Desensitization, Immunologic; Erythema; Exanthema; Female; Humans; Male; Platelet Aggregation Inhibitors; Pruritus; Ticlopidine | 2007 |
The validation of a bioanalytical method for the determination of clopidogrel in human plasma.
Topics: Chromatography, High Pressure Liquid; Clopidogrel; Humans; Molecular Structure; Platelet Aggregation Inhibitors; Reproducibility of Results; Tandem Mass Spectrometry; Ticlopidine | 2007 |
The fragmentation reactions of anti-platelet drugs: clopidogrel and ticlopidine.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Clopidogrel; Platelet Aggregation Inhibitors; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Therapeutic Equivalency; Ticlopidine | 2007 |
Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Drug Delivery Systems; Female; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine; Treatment Outcome | 2007 |
Effect of a prior authorization process on antiplatelet therapy and outcomes in patients prescribed clopidogrel following coronary stenting.
Topics: Aged; Alberta; Angioplasty, Balloon, Coronary; Blue Cross Blue Shield Insurance Plans; Clopidogrel; Cost Sharing; Drug Prescriptions; Female; Health Policy; Humans; Male; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Time Factors | 2006 |
Effect of clopidogrel on the inflammatory progression of early atherosclerosis in rabbits model.
Topics: Animals; Aspirin; Atherosclerosis; Atorvastatin; Chemokine CCL2; Clopidogrel; Diet, Atherogenic; Disease Models, Animal; Femoral Artery; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Intercellular Adhesion Molecule-1; Male; P-Selectin; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Ticlopidine; Vascular Cell Adhesion Molecule-1 | 2007 |
[Acute coronary syndrome: when an indication for clopidogrel?].
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Premedication; Stents; Ticlopidine | 2006 |
The effects of preinjury clopidogrel use on older trauma patients with head injuries.
Topics: Accidental Falls; Accidents, Traffic; Age Factors; Aged; Clopidogrel; Craniocerebral Trauma; Female; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Wounds and Injuries | 2006 |
Stroke: the dashed hopes of neuroprotection.
Topics: Acute Disease; Aspirin; Benzenesulfonates; Carotid Arteries; Clopidogrel; Dipyridamole; Europe; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neuroprotective Agents; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Stroke; Ticlopidine | 2007 |
Anticoagulant and antiplatelet therapy use in patients with atrial fibrillation undergoing percutaneous coronary intervention: the need for consensus and a management guideline.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Cohort Studies; Combined Modality Therapy; Consensus Development Conferences as Topic; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Heparin, Low-Molecular-Weight; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Stents; Stroke; Ticlopidine; Warfarin | 2006 |
Clopidogrel resistance: role of body mass and concomitant medications.
Topics: Benzodiazepines; Body Mass Index; Clopidogrel; Drug Interactions; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Risk Factors; Selective Serotonin Reuptake Inhibitors; Thromboembolism; Ticlopidine | 2007 |
Clinical trials update from the annual scientific session of the American College of Cardiology 2006.
Topics: Aspirin; Cardiac Catheterization; Cardiology; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Enoxaparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Societies, Medical; Stents; Thrombolytic Therapy; Ticlopidine; United States | 2006 |
Drug eluting stents.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Drug Implants; Humans; Platelet Aggregation Inhibitors; Prosthesis Failure; Referral and Consultation; Sirolimus; Stents; Thrombosis; Ticlopidine | 2006 |
Late ischemic events after clopidogrel cessation following drug-eluting stenting: should we be worried?
Topics: Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug Delivery Systems; Humans; Immunosuppressive Agents; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2006 |
Effects of applying a standardised management algorithm for moderate to severe renal dysfunction in patients with chronic stable heart failure.
Topics: Aged; Algorithms; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Creatinine; Female; Heart Failure; Humans; Kidney Diseases; Magnetic Resonance Angiography; Male; Prognosis; Prospective Studies; Renal Artery Obstruction; Risk Factors; Severity of Illness Index; Sickness Impact Profile; Ticlopidine; Treatment Outcome | 2007 |
Risk stratification for patients undergoing nonurgent percutaneous coronary intervention using N-terminal pro-B-type natriuretic peptide: a Clopidogrel for the Reduction of Events During Observation (CREDO) substudy.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Myocardial Infarction; Natriuretic Peptide, Brain; Peptide Fragments; Platelet Aggregation Inhibitors; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Stroke Volume; Survival Analysis; Ticlopidine | 2007 |
Platelet reactivity in patients with subacute stent thrombosis compared with non-stent-related acute myocardial infarction.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Female; Flow Cytometry; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
Long-term cost-effectiveness of clopidogrel in patients with acute coronary syndrome without ST-segment elevation in Germany.
Topics: Acute Coronary Syndrome; Adult; Age Factors; Aged; Aspirin; Clopidogrel; Cost-Benefit Analysis; Electrocardiography; Female; Germany; Humans; Male; Markov Chains; Middle Aged; Models, Economic; Myocardial Infarction; Platelet Aggregation Inhibitors; Sex Factors; Ticlopidine | 2007 |
A new caution for patients with drug-coated stents.
Topics: Clopidogrel; Coronary Disease; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Refusal | 2006 |
Clopidogrel bisulfate: in ST-segment elevation myocardial infarction: a viewpoint by Steven R Steinhubl.
Topics: Aged; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
Clopidogrel bisulfate in st-segment elevation myocardial infarction: a viewpoint by Deepak L Bhatt.
Topics: Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2006 |
[Safety of aspirin, clopidogrel, and acenocumarol combination in patients requiring anticoagulation].
Topics: Acenocoumarol; Aged; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2006 |
[Clopidrogrel and deficiency of glucose 6 phosphate dehydrogenase].
Topics: Aged; Brain Infarction; Clopidogrel; Glucosephosphate Dehydrogenase; Glucosephosphate Dehydrogenase Deficiency; Hematologic Tests; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2006 |
Clopidogrel-precipitated rhabdomyolysis in a stable heart transplant patient.
Topics: Clopidogrel; Cyclosporine; Drug Therapy, Combination; Female; Heart Transplantation; Humans; Middle Aged; Rhabdomyolysis; Simvastatin; Ticlopidine | 2007 |
[Platelet inhibition and gastric problems].
Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
[Agranulocytosis in a patient treated with metamizole and clopidogrel].
Topics: Aged; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow; Cerebral Infarction; Clopidogrel; Dipyrone; Drug Interactions; Drug Therapy, Combination; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Leukopenia; Male; Osteoarthritis, Knee; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine | 2006 |
Does clopidogrel each day keep stent thrombosis away?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Drug Delivery Systems; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Thrombosis; Ticlopidine | 2007 |
Stent thrombosis: consider also low response to antiplatelets.
Topics: Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Implants; Humans; Platelet Aggregation Inhibitors; Prosthesis Failure; Stents; Ticlopidine | 2007 |
Stent thrombosis: patient card on discontinuing clopidogrel is available.
Topics: Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Implants; Humans; Medical Records; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
Primary stent therapy for symptomatic intracranial atherosclerotic stenosis: 1-year follow-up angiographic and midterm clinical outcomes.
Topics: Adult; Aged; Aspirin; Cerebral Angiography; Clopidogrel; Female; Follow-Up Studies; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Neurologic Examination; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2006 |
Prevention of vascular events in atrial fibrillation.
Topics: Accidental Falls; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2007 |
Posttraumatic subgaleal hematoma with orbital extension associated with clopidogrel usage in an elderly patient: case report.
Topics: Accidental Falls; Aged; Clopidogrel; Female; Hematoma; Humans; Orbit; Periosteum; Platelet Aggregation Inhibitors; Radiography; Skull; Ticlopidine; Urinary Tract Infections | 2007 |
Platelet non-responsiveness to dual antiplatelet therapy and relation to coronary disease among diabetes patients.
Topics: Adult; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Coronary Disease; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pilot Projects; Reference Values; Risk Assessment; Ticlopidine; Treatment Failure | 2007 |
Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation.
Topics: Adenosine Diphosphate; Blood Platelets; Clopidogrel; Coronary Disease; Diabetic Angiopathies; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
Late in-stent thrombosis following carotid angioplasty and stenting.
Topics: Aged; Aged, 80 and over; Angiography, Digital Subtraction; Angioplasty, Balloon; Anticoagulants; Aphasia; Aspirin; Basal Ganglia; Calcinosis; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Hematuria; Heparin; Humans; Infarction, Middle Cerebral Artery; Male; Mouth Neoplasms; Neck Dissection; Neoplasm Recurrence, Local; Paresis; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Ultrasonography; Urinary Bladder Neoplasms; Vertigo | 2007 |
Atherothrombotic events and clopidogrel therapy.
Topics: Aged; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Embolism, Cholesterol; Enzyme Inhibitors; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Thrombosis; Ticlopidine | 2007 |
Combination antiplatelet therapy with aspirin and clopidogrel: the role of antecedent and concomitant doses of aspirin. An analysis of 711 patients.
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine | 2007 |
High post-treatment platelet reactivity is associated with a high incidence of myonecrosis after stenting for non-ST elevation acute coronary syndromes.
Topics: Acute Disease; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; France; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prognosis; Prospective Studies; Research Design; Risk Factors; Stents; Syndrome; Ticlopidine; Time Factors; Troponin I | 2007 |
Severe neutropenia under clopidogrel treatment three weeks after coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Female; Humans; Neutropenia; Platelet Aggregation Inhibitors; Severity of Illness Index; Stents; Ticlopidine; Time Factors | 2007 |
Safety and efficacy of combined antiplatelet-warfarin therapy after coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Prosthesis Failure; Retrospective Studies; Stents; Ticlopidine; Warfarin | 2007 |
Long-term outcomes in treating left main trifurcation coronary artery disease with the Paclitaxel-eluting stent.
Topics: Aged; Catheterization; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Drug Delivery Systems; Female; Humans; Logistic Models; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome; Tubulin Modulators | 2007 |
Suicide attempt with clopidogrel.
Topics: Clopidogrel; Drug Overdose; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Suicide, Attempted; Ticlopidine | 2006 |
Does heart failure etiology, New York Heart Association class, or ejection fraction affect the ability of clopidogrel to inhibit heightened platelet activity?
Topics: Aged; Aged, 80 and over; Aspirin; Biomarkers; Clopidogrel; Drug Evaluation; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Contraction; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Retrospective Studies; Stroke Volume; Ticlopidine | 2007 |
[Impact of the choice of an antiplatelet therapy for peripheral arterial disease: cost-effectiveness ratio and health economics assessment].
Topics: Aspirin; Clopidogrel; Cost-Benefit Analysis; Humans; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Variability in response to clopidogrel: where is the threshold for 'low response'?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine; Treatment Failure | 2007 |
CHARISMA: the antiplatelet saga continues.
Topics: Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2007 |
Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate?
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recurrence; Stents; Thrombelastography; Ticlopidine | 2007 |
[Clopidogrel versus acetylsalicylic acid in the secondary prophylaxis of vascular diseases. A commentary on the report of the Institute for Quality and Efficiency in the Health Service].
Topics: Academies and Institutes; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemotherapy, Adjuvant; Clopidogrel; Humans; National Health Programs; Platelet Aggregation Inhibitors; Quality Assurance, Health Care; Secondary Prevention; Ticlopidine; Vascular Diseases | 2007 |
Persistent platelet activation is related to very early cardiovascular events in patients with acute coronary syndromes.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Recurrence; Risk Assessment; Syndrome; Ticlopidine | 2007 |
Management of a spontaneous renal capsule hematoma following cardiac catheterization involving use of a platelet glycoprotein IIb/IIIa inhibitor: a case report.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Catheterization; Clopidogrel; Coronary Stenosis; Embolization, Therapeutic; Female; Hematoma; Humans; Immunoglobulin Fab Fragments; Kidney Diseases; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Radiography, Interventional; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2007 |
Highly selective copper-catalyzed ring expansion of vinyl thiiranes: application to synthesis of biotin and the heterocyclic core of plavix.
Topics: Biotin; Catalysis; Clopidogrel; Copper; Heterocyclic Compounds; Sulfides; Thiophenes; Ticlopidine; Vinyl Compounds | 2007 |
Consistent platelet inhibition during long-term maintenance-dose clopidogrel therapy among 359 compliant outpatients with documented vascular disease.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Integrin beta3; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Function Tests; Platelet Membrane Glycoprotein IIb; Risk Factors; Ticlopidine; Vascular Diseases | 2007 |
TNF-alpha and IL-8 in acute stroke and the modulation of these cytokines by antiplatelet agents.
Topics: Acute Disease; Adult; Aged; Aspirin; Brain Ischemia; Cells, Cultured; Clopidogrel; Dipyridamole; Female; Humans; In Vitro Techniques; Interleukin-8; Leukocytes; Male; Middle Aged; Piracetam; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Tumor Necrosis Factor-alpha | 2007 |
Acute coronary syndromes, response to clopidogrel, and worsened cardiovascular outcomes: the hen and the egg dilemma.
Topics: Clopidogrel; Death, Sudden, Cardiac; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stents; Ticlopidine | 2007 |
Clopidogrel inhibits platelet aggregation in patients on aspirin with stable chronic angina pectoris.
Topics: Angina Pectoris; Aspirin; Chronic Disease; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.
Topics: Animals; Aspirin; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Factor Xa; Fibrinolytic Agents; Hemorrhage; Hemostasis; Isoxazoles; Male; Platelet Aggregation; Pyrazoles; Rabbits; Thrombosis; Ticlopidine | 2007 |
Internal carotid artery stenosis with ipsilateral persistent hypoglossal artery presenting as a multiterritorial embolic infarction: a case report.
Topics: Aged; Aspirin; Basilar Artery; Brain; Carotid Artery, Internal; Carotid Stenosis; Cerebral Infarction; Clopidogrel; Contrast Media; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Female; Humans; Imaging, Three-Dimensional; Intracranial Embolism; Magnetic Resonance Angiography; Platelet Aggregation Inhibitors; Radiography; Rare Diseases; Ticlopidine; Vertigo | 2007 |
Clopidogrel-mediated reduction of circulating tissue factor in patients with stable coronary artery disease.
Topics: Adult; CD40 Ligand; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Solubility; Thromboplastin; Ticlopidine; Treatment Outcome | 2007 |
Determination of aspirin responsiveness by use of whole blood platelet aggregometry.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Blood Donors; Clopidogrel; Collagen; Coronary Artery Disease; Drug Resistance; Electric Impedance; Female; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridines; Reference Values; Sex Factors; Thromboxane B2; Ticlopidine | 2007 |
Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome.
Topics: Acute Disease; Aged; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Electrocardiography; Female; Gene Frequency; Genotype; Heart Diseases; Heterozygote; Homozygote; Humans; Male; Microfilament Proteins; Middle Aged; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2007 |
Acute coronary syndrome in an adult with anomalous origin of the left anterior descending coronary artery from the pulmonary trunk.
Topics: Adrenergic beta-Antagonists; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Vessel Anomalies; Echocardiography; Electrocardiography; Female; Humans; Middle Aged; Ticlopidine | 2007 |
Interaction study of aspirin or clopidogrel on pharmacokinetics of donepezil hydrochloride in rats by HPLC-fluorescence detection.
Topics: Administration, Oral; Animals; Aspirin; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Clopidogrel; Donepezil; Drug Interactions; Fluorescence; Indans; Injections, Intraperitoneal; Male; Molecular Structure; Piperidines; Rats; Rats, Wistar; Ticlopidine | 2007 |
[Platelet responsiveness to clopidogrel in patients with coronary syndrome. Comparison of platelet aggregation induced by ADP and flow cytometric analysis of intraplatelet VASP phosphorylation].
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Blood Proteins; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Follow-Up Studies; Humans; Male; Microfilament Proteins; Myocardial Infarction; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Syndrome; Ticlopidine | 2007 |
Response to letter of Dr van Werkum et al.
Topics: Clopidogrel; Coronary Thrombosis; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Late blood clots tarnish drug-coated stents. Uncommon complication raises questions about who really needs a drug-coated stent and how long to continue drug therapy after getting one.
Topics: Aspirin; Clopidogrel; Coronary Restenosis; Drug Implants; Forecasting; Foreign Bodies; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
Characterizing early prescribers of newly marketed drugs in Canada: a population-based study.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Alendronate; Attitude of Health Personnel; Celecoxib; Clopidogrel; Data Collection; Diffusion of Innovation; Drug Prescriptions; Drug Utilization; Family Practice; Female; Humans; Insurance, Health, Reimbursement; Male; Manitoba; Middle Aged; Pantoprazole; Practice Patterns, Physicians'; Pyrazoles; Socioeconomic Factors; Sulfonamides; Ticlopidine; Time Factors | 2007 |
Double-trouble: three cases with simultaneous stent thrombosis in different coronary arteries.
Topics: Aged; Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Coronary Thrombosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine; Time Factors | 2007 |
Protein disulphide isomerase-mediated LA419- NO release provides additional antithrombotic effects to the blockade of the ADP receptor.
Topics: Administration, Oral; Animals; Blood Coagulation; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Female; Fibrinolytic Agents; Isosorbide Dinitrate; Nitric Oxide; Nitric Oxide Donors; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Disulfide-Isomerases; Proteomics; Purinergic P2 Receptor Antagonists; Random Allocation; Receptors, Purinergic P2; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Thrombosis; Ticlopidine; Vasodilator Agents | 2007 |
Update on the use of antiplatelet agents in secondary stroke prevention.
Topics: Arteriosclerosis; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Embolism, Cholesterol; Humans; Platelet Aggregation Inhibitors; Stroke; Thromboembolism; Ticlopidine | 2007 |
[Hepatic toxicity and clopidogrel-induced systemic inflammatory response syndrome].
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Systemic Inflammatory Response Syndrome; Ticlopidine | 2007 |
In-hospital and late outcomes after coronary stenting in patient with unstable angina and myelodysplastic syndrome.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Platelet Aggregation Inhibitors; Platelet Transfusion; Stents; Ticlopidine; Treatment Outcome | 2006 |
Selective serotonin reuptake inhibitors may interfere with the antiplatelet effect of clopidogrel.
Topics: Antidepressive Agents, Second-Generation; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Depression; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Prognosis; Selective Serotonin Reuptake Inhibitors; Ticlopidine | 2007 |
Assessment of clopidogrel responsiveness: measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients.
Topics: Adenosine Diphosphate; Aged; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors | 2007 |
Ticlopidine could be an alternative therapy in the case of pharmacological resistance to clopidogrel: a report of three cases.
Topics: Aged; Angina, Unstable; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2007 |
Evaluation of the platelet response to clopidogrel with light transmittance aggregometry: peak aggregation or late aggregation?
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Hematologic Tests; Humans; Light; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk; Ticlopidine | 2007 |
Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E. coli: toward practical and green access to clopidogrel.
Topics: Alcohol Oxidoreductases; Biotransformation; Clopidogrel; Escherichia coli; Industrial Microbiology; Mandelic Acids; Molecular Structure; Phenylacetates; Stereoisomerism; Ticlopidine | 2007 |
Impact of prior antiplatelet therapy on risk of embolism in infective endocarditis.
Topics: Aged; Aspirin; Clopidogrel; Dipyridamole; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Embolism; Endocarditis, Bacterial; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Prevalence; Retrospective Studies; Risk Assessment; Stroke; Ticlopidine | 2007 |
The influence of primary care prescribing rates for new drugs on spontaneous reporting of adverse drug reactions.
Topics: Adverse Drug Reaction Reporting Systems; Antidepressive Agents, Second-Generation; Antimetabolites, Antineoplastic; Bupropion; Capecitabine; Citalopram; Clopidogrel; Cyclooxygenase 2 Inhibitors; Deoxycytidine; Drug Monitoring; Drug Prescriptions; Drug Utilization Review; Fluorouracil; Humans; Lactones; Meningococcal Vaccines; Platelet Aggregation Inhibitors; Primary Health Care; Scotland; Sulfones; Ticlopidine; Time Factors | 2007 |
Clopidogrel (Plavix) reduces the rate of thrombosis in the rat tuck model for microvenous anastomosis.
Topics: Anastomosis, Surgical; Animals; Clopidogrel; Male; Microsurgery; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Suture Techniques; Thrombosis; Ticlopidine; Vascular Surgical Procedures; Veins | 2007 |
Effects of clopidogrel on survival of rat skin flaps.
Topics: Animals; Clopidogrel; Graft Survival; Male; Necrosis; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Wistar; Surgical Flaps; Ticlopidine | 2007 |
[Clinically manifest gastrointestinal bleeding in patients subject to coronary angiography].
Topics: Abciximab; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Coronary Angiography; Duodenal Ulcer; Esophagitis; Female; Gastrointestinal Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Stomach Ulcer; Ticlopidine | 2007 |
Biomarker optimization to track the antithrombotic and hemostatic effects of clopidogrel in rats.
Topics: Adenosine Diphosphate; Animals; Aspirin; Biomarkers; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemostatics; Male; Membrane Proteins; Microfilament Proteins; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2007 |
Impact of aspirin with or without clopidogrel on postoperative bleeding and blood transfusion in coronary surgical patients treated prophylactically with a low-dose of aprotinin.
Topics: Aged; Aprotinin; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Hemostatics; Humans; Intraoperative Care; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Risk Factors; Ticlopidine | 2007 |
Does glycoprotein IIIa gene (Pl(A)) polymorphism influence clopidogrel resistance? : a study in older patients.
Topics: Adult; Aged; Alleles; Brain Ischemia; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Ticlopidine | 2007 |
Primary percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; Myocardial Infarction; Platelet Aggregation Inhibitors; Spironolactone; Ticlopidine | 2007 |
Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization.
Topics: Aged; Angioplasty, Balloon, Coronary; Anthropometry; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Death, Sudden, Cardiac; Drug Implants; Drug Utilization; Endothelium, Vascular; Equipment Design; Equipment Failure; Female; Follow-Up Studies; Humans; Hyperplasia; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine; Tunica Intima; Wound Healing | 2007 |
A case report of simultaneous thrombosis of two coronary artery stents in association with clopidogrel resistance.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug Resistance; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine | 2007 |
The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Clopidogrel; Cyclic AMP; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Rats; Rats, Sprague-Dawley; Thiophenes; Ticlopidine | 2007 |
Clopidogrel and long-term outcomes after drug-eluting stent implantation.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine | 2007 |
Clopidogrel and long-term outcomes after drug-eluting stent implantation.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine | 2007 |
Clopidogrel and long-term outcomes after drug-eluting stent implantation.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Cost-Benefit Analysis; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine | 2007 |
Clopidogrel and long-term outcomes after drug-eluting stent implantation.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Risk Assessment; Sirolimus; Stents; Ticlopidine | 2007 |
Risk of major bleeding with concomitant dual antiplatelet therapy after percutaneous coronary intervention in patients receiving long-term warfarin therapy.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Cohort Studies; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; International Normalized Ratio; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Risk Factors; Ticlopidine; Warfarin | 2007 |
Recombinant activated factor VII treatment of retroperitoneal hematoma in a patient with renal failure receiving enoxaparin and clopidogrel.
Topics: Aged; Angiography; Anticoagulants; Blood Component Transfusion; Clopidogrel; Drug Interactions; Embolization, Therapeutic; Enoxaparin; Factor VII; Factor VIIa; Female; Hematoma; Hemoglobins; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Recombinant Proteins; Renal Insufficiency; Retroperitoneal Space; Ticlopidine; Tomography, X-Ray Computed | 2007 |
Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance': a rebuttal.
Topics: Adenosine Diphosphate; Blood Platelets; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Endpoints in studies on myocardial infarction.
Topics: Clopidogrel; Coronary Disease; Endpoint Determination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 2007 |
Determination of clopidogrel in human plasma by liquid chromatography/tandem mass spectrometry: application to a clinical pharmacokinetic study.
Topics: Adult; Chromatography, Liquid; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Ticlopidine | 2007 |
Perioperative management of trauma patients admitted on clopidogrel (Plavix). A survey of orthopaedic departments across the United Kingdom.
Topics: Clinical Protocols; Clopidogrel; Drug Administration Schedule; Evidence-Based Medicine; Health Care Surveys; Hip Fractures; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Professional Practice; Ticlopidine; Time Factors | 2007 |
[Acute stent thrombosis due to resistance to clopidogrel ? A case report].
Topics: Aged; Clopidogrel; Drug Resistance; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.
Topics: Animals; Arteriovenous Shunt, Surgical; Carotid Artery Injuries; Clopidogrel; Disease Models, Animal; Dogs; In Vitro Techniques; Male; Membrane Proteins; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine | 2007 |
Late thrombosis of a drug-eluting stent during combined anti-platelet therapy in a clopidogrel nonresponsive diabetic patient: shall we routinely test platelet function?
Topics: Aged; Clopidogrel; Coronary Thrombosis; Coronary Vessels; Diabetic Angiopathies; Drug Resistance; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2007 |
Utility of whole blood impedance aggregometry for the assessment of clopidogrel action using the novel Multiplate analyzer--comparison with two flow cytometric methods.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Drug Resistance; Electric Impedance; Female; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Rate, degree, and predictors of recovery from disability following ischemic stroke.
Topics: Aged; Brain Ischemia; Causality; Clopidogrel; Cohort Studies; Diabetes Complications; Disability Evaluation; Female; Humans; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prognosis; Prospective Studies; Recovery of Function; Regression Analysis; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Noncardiogenic pulmonary edema associated with clopidogrel: a serious but unexpected side effect of clopidogrel.
Topics: Aged; Angioplasty; Blood Chemical Analysis; Carotid Stenosis; Clopidogrel; Diagnosis, Differential; Humans; Male; Platelet Aggregation Inhibitors; Pulmonary Edema; Radiography; Ticlopidine | 2007 |
Vasodilator-stimulated phosphoprotein phosphorylation analysis prior to percutaneous coronary intervention for exclusion of postprocedural major adverse cardiovascular events.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Ticlopidine; Vasodilator Agents | 2007 |
Outcomes and complications associated with off-label and untested use of drug-eluting stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Consumer Product Safety; Female; Hospital Mortality; Humans; Immunosuppressive Agents; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk; Sirolimus; Stents; Survival Analysis; Ticlopidine; Treatment Outcome; United States | 2007 |
[Interindividual variability in the laboratory response to the aspirin-clopidogrel combination: are patients with stent occlusion "resistant" to treatment?].
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Coronary Restenosis; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Ticlopidine | 2007 |
Increased incidence of stent thrombosis in patients with cocaine use.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cocaine-Related Disorders; Coronary Angiography; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Follow-Up Studies; Hospitals, Urban; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Research Design; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome; United States | 2007 |
Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits.
Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Aspirin; Biomarkers; Bleeding Time; Blood Platelets; Carotid Artery Thrombosis; Carotid Artery, Common; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Hemostasis; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Protein Binding; Rabbits; Receptors, Purinergic P2; Regional Blood Flow; Thromboxane B2; Ticlopidine | 2007 |
Drug-eluting stents.
Topics: Canada; Clopidogrel; Coronary Artery Disease; Cost-Benefit Analysis; Drug Delivery Systems; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
Managing acute coronary syndrome: evidence-based approaches.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Clinical Protocols; Clopidogrel; Coronary Disease; Drug Administration Schedule; Drug Therapy, Combination; Evidence-Based Medicine; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Outcome Assessment, Health Care; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Recombinant Proteins; Ticlopidine | 2007 |
Patterns of aspirin dosing in non-ST-elevation acute coronary syndromes in the CRUSADE Quality Improvement Initiative.
Topics: Acute Disease; Aged; Aged, 80 and over; Angina, Unstable; Aspirin; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Fibrinolytic Agents; Heart Conduction System; Humans; Male; Middle Aged; Patient Discharge; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Quality of Health Care; Retrospective Studies; Syndrome; Ticlopidine; Treatment Outcome; United States | 2007 |
Measuring aspirin resistance, clopidogrel responsiveness, and postprocedural markers of myonecrosis in patients undergoing percutaneous coronary intervention.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Clopidogrel; Coronary Artery Disease; Creatine Kinase, MB Form; Drug Resistance; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardium; Necrosis; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Period; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Ticlopidine; Treatment Outcome; Troponin I | 2007 |
[Treatment of intrastent restenosis by drug eluting stents: experience from one cardiology centre].
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Thrombosis; Equipment Design; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Paclitaxel; Platelet Aggregation Inhibitors; Prospective Studies; Sirolimus; Stents; Surface Properties; Ticlopidine; Treatment Outcome | 2007 |
Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Antiviral Agents; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Clopidogrel; Dose-Response Relationship, Drug; Female; Hepatocytes; Humans; Interleukin-6; Irinotecan; Liver Neoplasms; Male; Middle Aged; Oseltamivir; Platelet Aggregation Inhibitors; RNA, Messenger; Ticlopidine | 2007 |
Carotid artery in-stent restenosis in a patient with contralateral total occlusion, resolved with drug-eluting stenting.
Topics: Aged; Angioplasty, Balloon; Carotid Arteries; Carotid Artery Thrombosis; Carotid Stenosis; Catheterization; Clopidogrel; Constriction, Pathologic; Epilepsy, Tonic-Clonic; Filtration; Humans; Male; Platelet Aggregation Inhibitors; Prosthesis Fitting; Radiography; Recurrence; Renal Artery; Stents; Subclavian Steal Syndrome; Thrombolytic Therapy; Ticlopidine; Ultrasonography, Doppler | 2007 |
Factors related to progression of middle cerebral artery stenosis determined using transcranial Doppler ultrasonograhy.
Topics: Adenosine Diphosphate; Aged; Aspirin; Cerebral Angiography; Clopidogrel; Constriction, Pathologic; Disease Progression; Female; Humans; Infarction, Middle Cerebral Artery; Logistic Models; Magnetic Resonance Angiography; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2008 |
Timing of thrombotic events in patients receiving 2 weeks of clopidogrel therapy post bare metal coronary artery stenting: a New Zealand retrospective study.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Thrombosis; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Withholding Treatment | 2007 |
Clopidogrel and stent thrombosis after percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Coronary Restenosis; Coronary Thrombosis; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
Surgery or percutaneous coronary intervention for three-vessel and left main coronary artery disease: a critical appraisal of the literature.
Topics: Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
Factitious anticoagulant-resistance as a cause of recurrent arterial bypass graft occlusions.
Topics: Anticoagulants; Arterial Occlusive Diseases; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Factitious Disorders; Female; Graft Occlusion, Vascular; Heparin, Low-Molecular-Weight; Hirudins; Humans; Iliac Artery; Middle Aged; Munchausen Syndrome; Phenprocoumon; Platelet Aggregation Inhibitors; Recombinant Proteins; Recurrence; Reoperation; Ticlopidine; Treatment Refusal; Vascular Surgical Procedures | 2007 |
Utilisation review of clopidogrel: are they used under the FDA-approved indications?
Topics: Acute Coronary Syndrome; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Drug Utilization Review; Hospitals, University; Humans; Inpatients; Medical Records; Middle Aged; Outpatients; Platelet Aggregation Inhibitors; Retrospective Studies; Thailand; Ticlopidine; United States; United States Food and Drug Administration | 2007 |
Residual platelet reactivity is associated with clinical and laboratory characteristics in patients with ischemic heart disease undergoing PCI on dual antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Myocardial Ischemia; Platelet Aggregation Inhibitors; Protein Isoforms; Risk Factors; Ticlopidine | 2007 |
Long-term safety and efficacy of drug-eluting stents: two-year results of the REAL (REgistro AngiopLastiche dell'Emilia Romagna) multicenter registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Coronary Thrombosis; Coronary Vessels; Diabetes Mellitus; Drug Implants; Female; Follow-Up Studies; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Registries; Renal Insufficiency; Risk Factors; Sirolimus; Stents; Ticlopidine; Treatment Outcome | 2007 |
Residual platelet activity is increased in clopidogrel- and ASA-treated patients with coronary stenting for acute coronary syndromes compared with stable coronary artery disease.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Cohort Studies; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2008 |
Confined late stent thrombosis following clopidogrel withdrawal in a patient with multi-segment sirolimus-eluting stent implants.
Topics: Abciximab; Aged; Angioplasty, Balloon; Antibodies, Monoclonal; Anticoagulants; Clopidogrel; Coronary Artery Disease; Coronary Stenosis; Coronary Thrombosis; Heparin; Humans; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Male; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine | 2007 |
Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis.
Topics: Adult; Antineoplastic Agents, Phytogenic; Blood Platelets; Clopidogrel; Comorbidity; Female; Humans; Immunosuppressive Agents; Male; Multivariate Analysis; Myocardial Ischemia; Paclitaxel; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Sirolimus; Stents; Thrombosis; Ticlopidine | 2007 |
Unraveling questions surrounding clopidogrel resistance and stent thrombosis: one less snag.
Topics: Blood Platelets; Clopidogrel; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
The use of clopidogrel in carotid endarterectomy: an audit of current practice.
Topics: Aspirin; Cerebrovascular Disorders; Clopidogrel; Endarterectomy, Carotid; Hemorrhage; Humans; Medical Audit; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Surveys and Questionnaires; Ticlopidine | 2007 |
Comments on "Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel".
Topics: Antiviral Agents; Biotransformation; Carboxylic Ester Hydrolases; Clopidogrel; Drug Interactions; Humans; Oseltamivir; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Comparison of different methods to evaluate the effect of aspirin on platelet function in high-risk patients with ischemic heart disease receiving dual antiplatelet treatment.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Sensitivity and Specificity; Ticlopidine | 2007 |
Comparison of drug-eluting stents with bare metal stents in unselected patients with acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Agents; Cardiovascular Diseases; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Feasibility Studies; Female; Follow-Up Studies; Humans; Incidence; Kaplan-Meier Estimate; Male; Metals; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prosthesis Design; Risk Assessment; Secondary Prevention; Sirolimus; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Influence of antiplatelet therapy on cerebral micro-emboli after carotid endarterectomy using postoperative transcranial Doppler monitoring.
Topics: Aged; Anticoagulants; Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Dextrans; Dipyridamole; Drug Combinations; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Hemorrhage; Humans; Intracranial Embolism; Ischemic Attack, Transient; Male; Middle Aged; Middle Cerebral Artery; Pilot Projects; Platelet Aggregation Inhibitors; Postoperative Care; Randomized Controlled Trials as Topic; Research Design; Stroke; Ticlopidine; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2007 |
Duration of clopidogrel therapy after placement of drug-eluting intracoronary stent.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Drug Delivery Systems; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine; Time Factors | 2007 |
Clopidogrel-induced spontaneous spinal epidural hematoma.
Topics: Aged; Brain; Cerebral Angiography; Clopidogrel; Female; Hematoma, Epidural, Spinal; Humans; Ischemia; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Clopidogrel: the good, the bad, and the ugly.
Topics: Acute Disease; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine | 2007 |
Relationship between systolic pulsed wave tissue Doppler parameters and both invasive and noninvasive reperfusion criteria in patients with acute anterior myocardial infarction undergoing primary percutaneous coronary intervention.
Topics: Adult; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Echocardiography, Doppler, Pulsed; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors | 2008 |
[Anticoagulation in atrial fibrillation. ACTIVE Study (Arterial fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events)].
Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Aspirin; Atrial Fibrillation; Biphenyl Compounds; Clopidogrel; Drug Therapy, Combination; Follow-Up Studies; Hemorrhage; Humans; Intracranial Embolism; Irbesartan; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Tetrazoles; Thromboembolism; Ticlopidine | 2007 |
Relationships between optical aggregometry (type born) and flow cytometry in evaluating ADP-induced platelet activation.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Dual Specificity Phosphatase 2; Female; Flow Cytometry; Humans; Image Cytometry; Male; Microfilament Proteins; Middle Aged; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine | 2008 |
Impact of body mass index on platelet aggregation after administration of a high loading dose of 600 mg of clopidogrel before percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Body Mass Index; Clopidogrel; Female; Humans; Male; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Comparison of speed of onset of platelet inhibition after loading doses of clopidogrel versus prasugrel in healthy volunteers and correlation with responder status.
Topics: Clopidogrel; Humans; Nephelometry and Turbidimetry; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Time Factors | 2007 |
Uvula haematoma: a rare complication after thrombolysis and intensive anti-platelet treatment.
Topics: Anticoagulants; Chest Pain; Clopidogrel; Drug Therapy, Combination; Enoxaparin; Fibrinolytic Agents; Hematoma; Humans; Male; Middle Aged; Oral Hemorrhage; Streptokinase; Ticlopidine; Uvula | 2007 |
Spontaneous coronary hematoma during systemic thrombolysis for acute myocardial infarction: intracoronary ultrasound findings, percutaneous coronary intervention and complications.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Aneurysm; Drug Therapy, Combination; Female; Hematoma; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine; Treatment Outcome; Ultrasonography, Interventional | 2007 |
Do the Behring Coagulation Timer and the Platelet Function Analyzer-100 identify the same patients as being aspirin non-responders?
Topics: Aged; Arterial Occlusive Diseases; Aspirin; Automation; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2007 |
Treatment of acute myocardial infarction in pregnancy with coronary artery balloon angioplasty and stenting: use of tirofiban and clopidogrel.
Topics: Adult; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Myocardial Infarction; Pregnancy; Pregnancy Complications, Cardiovascular; Ticlopidine; Tirofiban; Tyrosine | 2008 |
Clopidogrel-statin interaction: myth or reality?
Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Comparison of platelet function and morphology in patients undergoing percutaneous coronary intervention receiving bivalirudin versus unfractionated heparin versus clopidogrel pretreatment and bivalirudin.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Blood Platelets; CD40 Ligand; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Female; Heparin; Hirudins; Humans; Male; Microscopy, Electron, Scanning; Middle Aged; Peptide Fragments; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine | 2007 |
Cerebellar hematoma complicating 600 mg loading dose of clopidogrel in combination with tirofiban.
Topics: Aged; Cerebellar Diseases; Clopidogrel; Drug Therapy, Combination; Hematoma; Humans; Male; Ticlopidine; Tirofiban; Tyrosine | 2008 |
PCI for stable coronary disease.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2007 |
[Spontaneous internal carotid artery dissection with paralysis of lower cranial nerves].
Topics: Aspirin; Carotid Artery, Internal, Dissection; Clopidogrel; Cranial Nerve Diseases; Humans; Paralysis; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine | 2007 |
Very late paclitaxel-eluting stent thrombosis despite 21 months of clopidogrel treatment after percutaneous coronary intervention.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Humans; Male; Middle Aged; Myocardial Ischemia; Paclitaxel; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prosthesis Design; Stents; Syndrome; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Case report on clopidogrel rash after coronary placement of a paclitaxol-coated stent.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Stenosis; Disease Progression; Drug Hypersensitivity; Drug Therapy, Combination; Exanthema; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Tubulin Modulators; Urticaria | 2007 |
Clopidogrel desensitization protocol for the treatment of thienopyridine hypersensitivity.
Topics: Algorithms; Angioplasty, Balloon, Coronary; Clinical Protocols; Clopidogrel; Desensitization, Immunologic; Drug Hypersensitivity; Exanthema; Humans; Patient Selection; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2007 |
[After coronary intervention. Which platelet inhibitor for whom?].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coated Materials, Biocompatible; Coronary Disease; Cost Control; Drug Costs; Drug Therapy, Combination; Germany; Humans; Myocardial Infarction; National Health Programs; Platelet Aggregation Inhibitors; Secondary Prevention; Stents; Ticlopidine | 2007 |
[Coronary heart disease patient does not tolerate acetylsalicylic acid. Can clopidogrel be prescribed?].
Topics: Aspirin; Clopidogrel; Contraindications; Coronary Disease; Drug Therapy, Combination; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2007 |
Aggressive antiplatelet strategies: time to reconsider?
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2007 |
Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19*2 allele on clopidogrel responsiveness.
Topics: Adult; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Outpatients; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6.
Topics: Catalysis; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Kinetics; Microsomes, Liver; Molecular Structure; Phencyclidine; Thiotepa; Ticlopidine | 2007 |
Clopidogrel resistance: a diagnostic challenge.
Topics: Cardiovascular Diseases; Clopidogrel; Diagnosis, Differential; Drug Resistance; Humans; Platelet Function Tests; Point-of-Care Systems; Ticlopidine | 2009 |
Cost-effectiveness of clopidogrel in myocardial infarction with ST-segment elevation: a European model based on the CLARITY and COMMIT trials.
Topics: Aged; Clopidogrel; Cohort Studies; Cost-Benefit Analysis; Decision Support Techniques; Drug Utilization Review; Female; France; Germany; Humans; Male; Markov Chains; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Survival Analysis; Sweden; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
[Modified platelet aggregation test in patients on ASA and/or clopidogrel].
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epinephrine; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thrombosis; Ticlopidine | 2007 |
[Suspected clopidogrel resistance associated with recurrent coronary stent thrombosis--a case report].
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug Resistance; Drug-Eluting Stents; Electrocardiography; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Genotype; Humans; Mixed Function Oxygenases; Mutation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Protein Isoforms; Regression Analysis; Ticlopidine; Time Factors; Treatment Outcome | 2007 |
Drug-eluting stents: dual antiplatelet therapy for every survivor?
Topics: Algorithms; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Incidence; Paclitaxel; Platelet Aggregation Inhibitors; Pyridines; Sirolimus; Stents; Survivors; Thrombosis; Ticlopidine | 2007 |
Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2007 |
An economic analysis of aspirin desensitization in aspirin-exacerbated respiratory disease.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Markov Chains; Middle Aged; Models, Biological; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Respiration Disorders; Ticlopidine | 2008 |
Perioperative thrombotic risk of coronary artery stents: possible role for intravenous platelet blockade.
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Humans; Injections, Intravenous; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Stents; Ticlopidine; Tirofiban; Tyrosine | 2007 |
Different methodologies for evaluating the effect of clopidogrel on platelet function in high-risk coronary artery disease patients.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Flow Cytometry; Humans; Male; Middle Aged; Phosphorylation; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2007 |
Admissions to a medical intensive care unit related to adverse drug reactions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Female; Hemorrhage; Hospitalization; Hospitals, Teaching; Humans; Intensive Care Units; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Clopidogrel poor responders: an objective definition based on Bayesian classification.
Topics: Adult; Bayes Theorem; Clopidogrel; Databases, Factual; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
The lack of endothelization after drug-eluting stent implantation as a cause of fatal late stent thrombosis.
Topics: Angioplasty, Balloon, Coronary; Autopsy; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Endothelial Cells; Fatal Outcome; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Prosthesis Design; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
[Treatment of carotid artery aneurysms with covered stents].
Topics: Adult; Alloys; Angiography, Digital Subtraction; Angioplasty; Aortic Dissection; Aspirin; Carotid Artery Diseases; Carotid Artery, External; Cerebral Angiography; Clopidogrel; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Polytetrafluoroethylene; Stents; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Treatment Outcome | 2007 |
Long-term clopidogrel therapy in patients receiving percutaneous coronary intervention.
Topics: Adult; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Cost-Benefit Analysis; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Ticlopidine | 2007 |
The "clopidogrel resistance" trap.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Humans; Patient Compliance; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Sirolimus-eluting stent thrombosis several years after clopidogrel discontinuation.
Topics: Adult; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Thrombosis; Drug Delivery Systems; Humans; Immunosuppressive Agents; Male; Platelet Aggregation Inhibitors; Sirolimus; Stents; Ticlopidine; Time Factors | 2007 |
A thromboxane A2/prostaglandin H2 receptor antagonist (S18886) shows high antithrombotic efficacy in an experimental model of stent-induced thrombosis.
Topics: Administration, Oral; Animals; Aorta; Aspirin; Bleeding Time; Blood Coagulation; Clopidogrel; Disease Models, Animal; Fibrin; Fibrinogen; Fibrinolytic Agents; Hemorrhage; Naphthalenes; Platelet Activation; Platelet Aggregation Inhibitors; Propionates; Prosthesis Design; Receptors, Thromboxane A2, Prostaglandin H2; Stainless Steel; Stents; Swine; Thrombosis; Ticlopidine; Time Factors | 2007 |
Clopidogrel anti-platelet effect: an evaluation by optical aggregometry, impedance aggregometry, and the platelet function analyzer (PFA-100).
Topics: Adult; Aged; Clopidogrel; Female; Hematologic Tests; Humans; Male; Middle Aged; Optics and Photonics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Sensitivity and Specificity; Ticlopidine | 2007 |
Poor responsiveness to clopidogrel: drug-specific or class-effect mechanism? Evidence from a clopidogrel-to-ticlopidine crossover study.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Confidence Intervals; Coronary Angiography; Coronary Stenosis; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Probability; Risk Factors; Ticlopidine; Treatment Outcome | 2007 |
Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project.
Topics: Adverse Drug Reaction Reporting Systems; Age Distribution; Aged; Analysis of Variance; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Plasma Exchange; Platelet Aggregation Inhibitors; Probability; Purpura, Thrombotic Thrombocytopenic; Pyridines; Risk Assessment; Severity of Illness Index; Sex Distribution; Survival Analysis; Ticlopidine | 2007 |
Angiographic and procedural correlates of stent thrombosis after intracoronary implantation of drug-eluting stents.
Topics: Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Heparin; Humans; Hypolipidemic Agents; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2007 |
Relationship between microvascular resistance and perfusion in patients with reperfused acute myocardial infarction.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Circulation; Coronary Stenosis; Coronary Vessels; Female; Health Status Indicators; Humans; Male; Microcirculation; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Perfusion; Prospective Studies; Severity of Illness Index; Ticlopidine | 2007 |
Is clopidogrel stopped prior to hip fracture surgery--A survey of current practice in the United Kingdom.
Topics: Anticoagulants; Aspirin; Clinical Protocols; Clopidogrel; Contraindications; Femoral Neck Fractures; Health Care Surveys; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Professional Practice; Surgery Department, Hospital; Ticlopidine; United Kingdom; Warfarin | 2007 |
Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus.
Topics: Adenoviridae; Adenoviridae Infections; Animals; Aspirin; Clopidogrel; Defective Viruses; Immune System Diseases; Leukocytes; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; T-Lymphocytes, Cytotoxic; Ticlopidine | 2007 |
Effects of glycoprotein IIb/IIIa blockers.
Topics: Abciximab; Antibodies, Monoclonal; Clinical Trials as Topic; Clopidogrel; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2007 |
Antiplatelet agents make a comeback in ST-elevation myocardial infarction.
Topics: Adenosine; Antifibrinolytic Agents; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2007 |
The impact of oral antiplatelet responsiveness on the long-term prognosis after coronary stenting.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Creatine Kinase, MB Form; Drug Therapy, Combination; Drug Tolerance; Female; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Secondary Prevention; Stents; Ticlopidine | 2007 |
Effect of caffeine on platelet inhibition by clopidogrel in healthy subjects and patients with coronary artery disease.
Topics: Adult; Aged; Caffeine; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Drug Synergism; Female; Humans; Hydrazones; Male; Middle Aged; P-Selectin; Phosphodiesterase Inhibitors; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptor, Adenosine A2A; Ticlopidine | 2007 |
Dual antiplatelet agent failure: a new syndrome or clinical nonentity?
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Recurrence; Syndrome; Ticlopidine; Treatment Outcome | 2007 |
Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Female; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reference Values; Research Design; Retrospective Studies; Thiophenes; Ticlopidine | 2007 |
Perioperative management of anticoagulant therapy during cutaneous surgery: 2005 survey of Mohs surgeons.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Dermatology; Drug Utilization Review; Humans; Mohs Surgery; Perioperative Care; Practice Patterns, Physicians'; Skin Diseases; Surveys and Questionnaires; Ticlopidine; United States; Vitamin E; Warfarin | 2007 |
Clopidogrel loading doses and outcomes of patients undergoing percutaneous coronary intervention for acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Databases, Factual; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2007 |
Of Swiss alchemists and road hazards.
Topics: Acute Coronary Syndrome; Cardiology; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Toxicology | 2007 |
Pattern of clopidogrel exposures reported to Texas poison centers during 1998-2004.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clopidogrel; Cross-Sectional Studies; Female; Humans; Infant; Male; Middle Aged; Platelet Aggregation Inhibitors; Poison Control Centers; Retrospective Studies; Texas; Ticlopidine; Time Factors | 2007 |
Triple antithrombotic therapy with aspirin, clopidogrel and warfarin--a persisting dilemma.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Risk Factors; Ticlopidine; Venous Thrombosis; Warfarin | 2007 |
Clopidogrel in addition to aspirin reduces one-year major adverse cardiac and cerebrovascular events in unselected patients with non-ST segment elevation myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Comorbidity; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Prognosis; Secondary Prevention; Stroke; Ticlopidine | 2008 |
Guideline-based discharge therapy for unstable angina pectoris/non-ST elevation myocardial infarction.
Topics: Angina, Unstable; Aspirin; Clopidogrel; Electrocardiography; Humans; Hypolipidemic Agents; Myocardial Infarction; Patient Discharge; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine; Time Factors | 2007 |
Safety of the cardiac triple therapy: the experience of the Quebec Heart Institute.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Quebec; Retrospective Studies; Risk Factors; Ticlopidine; Warfarin | 2007 |
Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.
Topics: Aged; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Death, Sudden, Cardiac; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Humans; Male; Multivariate Analysis; Myocardial Infarction; Outcome Assessment, Health Care; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prognosis; Prospective Studies; Renal Insufficiency; ROC Curve; Sensitivity and Specificity; Stroke; Ticlopidine | 2007 |
Sweet and sticky: diabetic platelets, enhanced reactivity, and cardiovascular risk.
Topics: Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Death, Sudden, Cardiac; Diabetes Mellitus, Type 2; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Stroke; Ticlopidine | 2007 |
Platelets and stents.
Topics: Angioplasty; Aspirin; Clopidogrel; Combined Modality Therapy; Humans; Intracranial Arteriosclerosis; Platelet Aggregation Inhibitors; Radiography; Stents; Ticlopidine | 2007 |
Platelet function testing and cardiovascular outcomes: steps forward in identifying the best predictive measure.
Topics: Adenosine Diphosphate; Cardiovascular Diseases; Clopidogrel; Flow Cytometry; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prognosis; Pyridines; ROC Curve; Sensitivity and Specificity; Ticlopidine; Treatment Outcome | 2007 |
ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Acute Disease; Adenosine Diphosphate; Aged; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Ischemia; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; ROC Curve; Ticlopidine; Treatment Outcome | 2007 |
Impaired platelet responsiveness to clopidogrel identified by flow cytometric vasodilator-stimulated phosphoprotein (VASP) phosphorylation in patients with subacute stent thrombosis.
Topics: Aged; Algorithms; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Models, Biological; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2007 |
The Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDICT) score.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angina Pectoris; Clopidogrel; Cohort Studies; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Models, Statistical; Platelet Aggregation; Platelet Function Tests; Regression Analysis; Stents; Ticlopidine | 2008 |
The CAPRIE-like subgroups of CHARISMA: a CAPRIEciously biased analysis of an unCHARISMAtic truth.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Research Design; Ticlopidine; Treatment Outcome | 2007 |
Temporal trends in antiplatelet/antithrombotic use in acute coronary syndromes and in-hospital major bleeding complications.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Cardiac Catheterization; Clopidogrel; Female; Fibrinolytic Agents; Hemorrhage; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 2007 |
Effectiveness and safety of reduced-dose enoxaparin in non-ST-segment elevation acute coronary syndrome followed by antiplatelet therapy alone for percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Aspirin; Atherectomy, Coronary; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Enoxaparin; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine | 2007 |
[Antithrombotic therapy in ischemic stroke and transient ischemic attack].
Topics: Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Recurrence; Stroke; Thromboembolism; Ticlopidine | 2007 |
Late coronary stent thrombosis complicating urologic surgery.
Topics: Aged; Clopidogrel; Coronary Stenosis; Drug-Eluting Stents; Fatal Outcome; Humans; Immunosuppressive Agents; Lymph Node Excision; Male; Paclitaxel; Platelet Aggregation Inhibitors; Prostatic Neoplasms; Thrombosis; Ticlopidine; Withholding Treatment | 2008 |
Clopidogrel and long-term outcomes after stent implantation for acute coronary syndrome.
Topics: Blood Vessel Prosthesis Implantation; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Postoperative Care; Retrospective Studies; Secondary Prevention; Stents; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome; United States | 2007 |
Treatment in a haemophiliac A patient with paroxysmal atrial fibrillation and ischemic heart disease.
Topics: Anticoagulants; Atrial Fibrillation; Clopidogrel; Follow-Up Studies; Hemophilia A; Heparin; HIV Infections; Humans; Male; Middle Aged; Myocardial Ischemia; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2007 |
Post-stenting antithrombotic drug therapy in patients with atrial fibrillation.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Fibrinolytic Agents; Humans; Practice Guidelines as Topic; Risk Factors; Stents; Thrombosis; Ticlopidine; Warfarin | 2007 |
Intensifying platelet inhibition--navigating between Scylla and Charybdis.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Ischemia; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2007 |
Letter by Fisher and Johns regarding article, "Variable platelet response to aspirin and clopidogrel in atherothrombotic disease".
Topics: Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Ticlopidine | 2007 |
Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension.
Topics: Actins; Adenosine Triphosphate; Angiotensin II; Animals; Arterioles; Blood Pressure; Cell Proliferation; Clopidogrel; Disease Models, Animal; Hypertension; Hypertrophy; Kidney; Male; Membrane Proteins; Mesangial Cells; Purinergic Antagonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Renin; Ticlopidine | 2008 |
Clinical trials update from the European Society of Cardiology Congress in Vienna, 2007: PROSPECT, EVEREST, ARISE, ALOFT, FINESSE, Prague-8, CARESS in MI and ACUITY.
Topics: Abciximab; Acute Coronary Syndrome; Amides; Antibodies, Monoclonal; Benzazepines; Clinical Trials as Topic; Clopidogrel; Electrocardiography; Europe; Fumarates; Heart Diseases; Heart Failure; Hirudins; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Peptide Fragments; Probucol; Recombinant Proteins; Ticlopidine; Tolvaptan | 2007 |
P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Genotype; Haplotypes; Humans; Male; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2008 |
Repeat oral dosing of prasugrel, a novel P2Y12 receptor inhibitor, results in cumulative and potent antiplatelet and antithrombotic activity in several animal species.
Topics: Administration, Oral; Adult; Animals; Clopidogrel; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; In Vitro Techniques; Macaca fascicularis; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Thiophenes; Thrombosis; Ticlopidine | 2008 |
Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2007 |
Endovascular treatment of a renal artery stenosis: techniques, indications, results. Role of embolic protection devices (part 2).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Catheterization; Clopidogrel; Embolism; Fibrinolytic Agents; Heparin; Hirudins; Humans; Peptide Fragments; Platelet Aggregation Inhibitors; Recombinant Proteins; Renal Artery Obstruction; Ticlopidine | 2007 |
Anti-inflammatory renoprotective effect of clopidogrel and irbesartan in chronic renal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Chronic Disease; Clopidogrel; Creatinine; Hypertension; Irbesartan; Kidney; Kidney Diseases; Nephrectomy; Platelet Aggregation Inhibitors; Rats; Tetrazoles; Ticlopidine; Wounds and Injuries | 2008 |
Clopidogrel versus aspirin in patients with atherothrombosis: CAPRIE-based calculation of cost-effectiveness for Germany.
Topics: Aged; Aged, 80 and over; Aspirin; Atherosclerosis; Clopidogrel; Cohort Studies; Coronary Thrombosis; Cost-Benefit Analysis; Germany; Humans; Models, Econometric; Myocardial Infarction; Platelet Aggregation Inhibitors; Survival Analysis; Ticlopidine; Treatment Outcome | 2008 |
[The effect of carotid stenting on rheological parameters, free radical production and platelet aggregation].
Topics: Aged; Carotid Stenosis; Clopidogrel; Female; Fibrinogen; Follow-Up Studies; Free Radicals; Hematocrit; Hemorheology; Humans; Male; Middle Aged; Oxidative Stress; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Stents; Ticlopidine; Time Factors | 2007 |
Multimodal thromboprophylaxis for total hip and knee arthroplasty based on risk assessment.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Aspirin; Clopidogrel; Combined Modality Therapy; Dipyridamole; Early Ambulation; Enoxaparin; Female; Fibrinolytic Agents; Hematologic Agents; Humans; Intermittent Pneumatic Compression Devices; Male; Middle Aged; Platelet Aggregation Inhibitors; Pulmonary Embolism; Retrospective Studies; Risk Assessment; Thromboembolism; Ticlopidine; Venous Thrombosis; Warfarin | 2007 |
[Prasugrel, a new thienopyridine].
Topics: Clinical Trials, Phase II as Topic; Clopidogrel; Coronary Thrombosis; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticlopidine | 2007 |
Coronary artery in-stent stenosis persists despite inhibition of the von Willebrand factor--collagen interaction in baboons.
Topics: Angioplasty, Balloon, Coronary; Animals; Antibodies, Monoclonal; Aspirin; Clopidogrel; Collagen; Coronary Stenosis; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Fibrinolytic Agents; Heparin; Male; Papio ursinus; Platelet Adhesiveness; Stents; Ticlopidine; Time Factors; Tunica Intima; von Willebrand Factor | 2007 |
Platelet mapping and desmopressin reversal of platelet inhibition during emergency carotid endarterectomy.
Topics: Blood Platelets; Carotid Stenosis; Clopidogrel; Deamino Arginine Vasopressin; Emergencies; Endarterectomy; Hemostatics; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Thrombelastography; Ticlopidine; Treatment Outcome | 2007 |
Coronary artery stents and non-cardiac surgery.
Topics: Clopidogrel; Coronary Restenosis; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stents; Ticlopidine | 2008 |
Expression of platelet surface receptors and early changes in platelet function in patients with STEMI treated with abciximab and clopidogrel versus clopidogrel alone.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Immunoglobulin Fab Fragments; Integrin beta3; Male; Middle Aged; Myocardial Infarction; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Ticlopidine | 2007 |
2007 Focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.
Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Chronic Disease; Clopidogrel; Contraindications; Coronary Angiography; Coronary Artery Bypass; Coronary Disease; Coronary Stenosis; Drug-Eluting Stents; Electrocardiography; Evidence-Based Medicine; Exercise Test; Humans; Kidney Diseases; Myocardial Infarction; Nomograms; Patient Selection; Platelet Aggregation Inhibitors; Prognosis; Radionuclide Ventriculography; Randomized Controlled Trials as Topic; Recurrence; Risk Assessment; Stents; Stroke Volume; Thrombolytic Therapy; Ticlopidine | 2008 |
The effect of platelet-altering medications on bleeding from minor oral surgery procedures.
Topics: Analysis of Variance; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Loss, Surgical; Blood Platelets; Case-Control Studies; Clopidogrel; Humans; Oral Surgical Procedures; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Ticlopidine | 2008 |
Perioperative complications in patients with drug-eluting stents: a three-year audit at Geelong Hospital.
Topics: Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Humans; Intraoperative Complications; Male; Medical Audit; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2007 |
A double blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days.
Topics: Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2008 |
Two strategies of clopidogrel loading dose to decrease the frequency of clopidogrel resistance in patients undergoing percutaneous coronary intervention.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Phosphorylation; Pilot Projects; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine | 2008 |
[Case of thrombotic thrombocytopenic purpura associated with clopidogrel].
Topics: Aged, 80 and over; Cerebral Infarction; Clopidogrel; Fatal Outcome; Female; Humans; Plasma Exchange; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2007 |
Iliac venous stenting: antithrombotic efficacy of PD0348292, an oral direct Factor Xa inhibitor, compared with antiplatelet agents in pigs.
Topics: Administration, Oral; Angioplasty; Animals; Antithrombin III; Aspirin; Clopidogrel; Constriction, Pathologic; Disease Models, Animal; Drug Therapy, Combination; Female; Iliac Vein; Preoperative Care; Probability; Pyridones; Pyrrolidines; Random Allocation; Reference Values; Stents; Ticlopidine; Treatment Outcome; Vascular Patency; Venous Thrombosis | 2008 |
Evaluating the impact of educational interventions on use of antithrombotics in Australia.
Topics: Adolescent; Adult; Aged; Anticoagulants; Australia; Clopidogrel; Databases, Factual; Dipyridamole; Drug Utilization; Education, Medical, Continuing; Fibrinolytic Agents; Humans; Linear Models; Middle Aged; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Retrospective Studies; Ticlopidine; Warfarin | 2008 |
The success of clopidogrel treatment for recurrent coronary thrombosis in a patient with aortic and mitral valve replacement.
Topics: Aortic Valve; Clopidogrel; Coronary Thrombosis; Female; Heart Valve Prosthesis; Humans; Middle Aged; Mitral Valve; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 2008 |
Anti-platelet agents and surgical delay in elderly patients with hip fractures.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Female; Hip Fractures; Humans; Male; Platelet Aggregation Inhibitors; Platelet Count; Retrospective Studies; Ticlopidine; Time Factors | 2007 |
Aspirin + clopidogrel therapy: how does your care compare to the evidence?
Topics: Acute Coronary Syndrome; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Evidence-Based Medicine; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2008 |
Antiplatelet agents for stroke prevention following transient ischemic attack.
Topics: Angioplasty, Balloon; Aspirin; Carotid Artery Diseases; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Endarterectomy, Carotid; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine | 2008 |
Gastrointestinal bleeding in patients receiving a combination of aspirin, clopidogrel, and enoxaparin in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Enoxaparin; Female; Gastrointestinal Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Statistics, Nonparametric; Ticlopidine | 2008 |
Prediction and prevention of stroke in patients with symptomatic carotid stenosis: the high-risk period and the high-risk patient.
Topics: Aspirin; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Prognosis; Recurrence; Risk Assessment; Stroke; Ticlopidine; Time Factors | 2008 |
Coronary artery stenting in patients treated by clopidogrel without aspirin.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2009 |
Plasminogen activator inhibitor-1 predicts coronary in-stent restenosis of drug-eluting stents.
Topics: Aged; Angiography; Clopidogrel; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Regression Analysis; Risk Factors; Ticlopidine; Time Factors; Tissue Plasminogen Activator; Treatment Outcome | 2008 |
Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Algorithms; Arachidonic Acid; Aspirin; Calibration; Clopidogrel; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Platelet-Rich Plasma; Sensitivity and Specificity; Thrombophilia; Ticlopidine | 2008 |
High dose clopidogrel decreases mice liver mitochondrial respiration function in vitro.
Topics: Animals; Cell Respiration; Clopidogrel; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Models, Animal; Oxidative Phosphorylation; Oxygen Consumption; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Development and metrological characterization of quantitative X-ray diffraction phase analysis for the mixtures of clopidogrel bisulphate polymorphs.
Topics: Clopidogrel; Ticlopidine; X-Ray Diffraction | 2008 |
Successful emergent surgical revascularization and retrieval of entrapped drug eluting stent.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Bypass; Coronary Stenosis; Device Removal; Drug-Eluting Stents; Emergency Medical Services; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retreatment; Ticlopidine; Treatment Refusal | 2008 |
Outcomes associated with combined antiplatelet and anticoagulant therapy.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Coronary Artery Disease; Dipyridamole; Drug Therapy, Combination; Female; Hemorrhage; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Thromboembolism; Ticlopidine; Treatment Outcome; Warfarin | 2008 |
Omeprazole: a possible new candidate influencing the antiplatelet effect of clopidogrel.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Antagonism; Drug Therapy, Combination; Humans; Mixed Function Oxygenases; Omeprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Stents; Ticlopidine | 2008 |
[Four years of circulatory support with the INCOR axial pump from Berlin Heart].
Topics: Clopidogrel; Coronary Thrombosis; Enoxaparin; Fibrinolytic Agents; Heart Failure; Heart-Assist Devices; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Portal vein thrombosis associated with coronary artery bypass surgery.
Topics: Aged; Aspirin; Bacteremia; Clopidogrel; Coagulase; Coronary Artery Bypass; Esophageal and Gastric Varices; Fatal Outcome; Gastrointestinal Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Portal Vein; Staphylococcus; Ticlopidine; Tomography, X-Ray Computed; Treatment Failure; Treatment Outcome; Venous Thrombosis | 2008 |
Clopidogrel in addition to aspirin reduces in-hospital major cardiac and cerebrovascular events in unselected patients with acute ST segment elevation myocardial.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cerebrovascular Disorders; Clopidogrel; Drug Therapy, Combination; Female; Heart Diseases; Hemorrhage; Hospital Mortality; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Research Design; Retrospective Studies; Risk Assessment; Risk Factors; Secondary Prevention; Stroke; Thrombolytic Therapy; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo.
Topics: Animals; Aorta; Apolipoproteins E; Aspirin; Atherosclerosis; Blood Platelets; Carotid Arteries; Cholesterol, Dietary; Clopidogrel; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Microscopy, Video; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Rupture; Thrombosis; Ticlopidine; Time Factors | 2008 |
Analysis of the upper gastrointestinal tract bleeding prevalence in patients treated due ischaemic heart disease.
Topics: Acenocoumarol; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Body Mass Index; Clopidogrel; Female; Gastrointestinal Tract; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation.
Topics: Abbreviations as Topic; Age Factors; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bendroflumethiazide; Clopidogrel; Delphi Technique; Digoxin; Diuretics; Drug Prescriptions; Drug Therapy; Drug Utilization Review; Drug-Related Side Effects and Adverse Reactions; Glomerular Filtration Rate; Health Services for the Aged; Humans; Ireland; Metformin; Practice Patterns, Physicians'; Reproducibility of Results; Risk Factors; Ticlopidine; Time Factors; United Kingdom | 2008 |
Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting.
Topics: Adult; Aged; Basilar Artery; Carotid Artery, Internal; Clopidogrel; Constriction, Pathologic; Drug Monitoring; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine; Vertebral Artery | 2008 |
Determination of clopidogrel main metabolite in plasma: a useful tool for monitoring therapy?
Topics: Aged; Chromatography, High Pressure Liquid; Clopidogrel; Female; Humans; Male; Mass Spectrometry; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Effects of a waiting period after clopidogrel treatment before performing coronary artery bypass grafting.
Topics: Academic Medical Centers; Blood Loss, Surgical; Blood Volume; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Erythrocyte Transfusion; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Postoperative Hemorrhage; Premedication; Preoperative Care; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Combined antithrombotic therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2008 |
In situ monitoring of polymorph transformation of clopidogrel hydrogen sulfate using measurement of ultrasonic velocity.
Topics: Calorimetry, Differential Scanning; Clopidogrel; Crystallization; Crystallography, X-Ray; Molecular Conformation; Platelet Aggregation Inhibitors; Solubility; Ticlopidine; Ultrasonics | 2008 |
Percutaneous coronary intervention without on site surgical back-up; two-years registry of a large Dutch community hospital.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Feasibility Studies; Female; Hospitals, Community; Humans; Male; Middle Aged; Myocardial Infarction; Netherlands; Platelet Aggregation Inhibitors; Registries; Risk Factors; Safety; Ticlopidine; Treatment Outcome | 2009 |
Clopidogrel treatment before coronary artery bypass graft surgery increases postoperative morbidity and blood product requirements.
Topics: Aged; Blood Coagulation Tests; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Erythrocyte Transfusion; Female; Hospital Mortality; Humans; Kaplan-Meier Estimate; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Postoperative Hemorrhage; Preoperative Care; Retrospective Studies; Risk Factors; Survival Rate; Ticlopidine; Time Factors | 2008 |
I had a drug-coated stent implanted in one of my coronary arteries. I have been taking aspirin and Plavix daily since the procedure. What determines the appropriate time for discontinuing these medications? Are there any negative aspects to continuing the
Topics: Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2007 |
Management of upper gastrointestinal haemorrhage complicating dual anti-platelet therapy.
Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Female; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Count; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2008 |
Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Cause of Death; Clopidogrel; Cluster Analysis; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Poisson Distribution; Proportional Hazards Models; Retrospective Studies; Risk; Ticlopidine; Time Factors; Withholding Treatment | 2008 |
The Cataract National Dataset electronic multicentre audit of 55,567 operations: antiplatelet and anticoagulant medications.
Topics: Aged; Anesthetics, Local; Anticoagulants; Aspirin; Blood Loss, Surgical; Cataract Extraction; Choroid Hemorrhage; Clopidogrel; Dipyridamole; Eye Hemorrhage; Humans; Intraoperative Complications; Lens Capsule, Crystalline; Platelet Aggregation Inhibitors; Risk Factors; Rupture; Ticlopidine; Warfarin | 2009 |
Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug-Eluting Stents; Epidemiologic Methods; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prognosis; Ticlopidine | 2008 |
Restrictive access to clopidogrel and mortality following coronary stent implantation.
Topics: Aged; Canada; Cause of Death; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Coronary Restenosis; Drug Costs; Drug Prescriptions; Female; Follow-Up Studies; Humans; Insurance, Pharmaceutical Services; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Survival Rate; Ticlopidine; Time Factors | 2008 |
A retrospective study of the management of retro-peritoneal bleeding after percutaneous coronary intervention in the era of combination anti-platelet therapy.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Coronary Disease; Female; Femoral Artery; Follow-Up Studies; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Length of Stay; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Retroperitoneal Space; Retrospective Studies; Ticlopidine; Treatment Outcome | 2008 |
Loss of taste with clopidogrel.
Topics: Aged; Ageusia; Clopidogrel; Humans; Male; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Weight Loss | 2008 |
Very late thrombosis in a bare metal stent: an under-recognized problem.
Topics: Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Thrombosis; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Thrombectomy; Ticlopidine | 2008 |
Platelet glycoprotein IIb/IIIa receptor inhibitors--end of an era?
Topics: Abciximab; Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Humans; Immunoglobulin Fab Fragments; Perioperative Care; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2008 |
Which patients receiving warfarin can be treated safely with a drug-eluting stent?
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Humans; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Stroke; Ticlopidine; Warfarin | 2008 |
How to optimise clopidogrel therapy? Reducing the low-response incidence by aggregometry-guided therapy modification.
Topics: Adenosine Diphosphate; Aged; Algorithms; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Cardiovascular Diseases; Clinical Protocols; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Drug Resistance; Feasibility Studies; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2008 |
Switching thienopyridines: hypothetical versus real risks.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Resistance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2008 |
Aspirin and clopidogrel use in the perioperative period for non-cardiac surgery.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Drug-Eluting Stents; Humans; Intraoperative Complications; Medical History Taking; Perioperative Care; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2008 |
The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses.
Topics: Adenosine Monophosphate; Adult; Annexin A5; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cytoplasmic Granules; Humans; In Vitro Techniques; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2008 |
Internal carotid artery stenting for blunt carotid artery injuries with an associated pseudoaneurysm.
Topics: Accidents, Traffic; Adolescent; Adult; Aneurysm, False; Aspirin; Carotid Artery Injuries; Carotid Artery, Internal; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Tomography, X-Ray Computed; Wounds, Nonpenetrating | 2008 |
Evidence for prolonged prescribing of aspirin-clopidogrel combination in Scottish primary care.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Male; Platelet Aggregation Inhibitors; Population Surveillance; Primary Health Care; Retrospective Studies; Scotland; Ticlopidine | 2008 |
Rapid oral aspirin desensitization for patients with aspirin allergy requiring dual antiplatelet therapy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Hypersensitivity; Drug Therapy, Combination; Humans; Inactivation, Metabolic; Membrane Proteins; Platelet Aggregation Inhibitors; Receptors, Leukotriene; Ticlopidine | 2008 |
Prevention of thrombosis in polycythemia vera and essential thrombocythemia.
Topics: Arterial Occlusive Diseases; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Hydroxyurea; Janus Kinase 2; Multicenter Studies as Topic; Phlebotomy; Polycythemia Vera; Retrospective Studies; Risk Factors; Severity of Illness Index; Thrombocythemia, Essential; Thrombophilia; Thrombosis; Ticlopidine; Venous Thrombosis | 2008 |
Effect of clopidogrel on neointimal formation and inflammation in balloon-denuded and radiated hypercholesterolemic rabbit iliac arteries.
Topics: Angioplasty, Balloon, Coronary; Animals; C-Reactive Protein; Clopidogrel; Endothelium, Vascular; Hypercholesterolemia; Iliac Artery; Inflammation; Macrophages; Male; P-Selectin; Platelet Aggregation Inhibitors; Rabbits; Ticlopidine; Tunica Intima | 2008 |
Effect of clopidogrel pretreatment on angiographic and clinical outcomes in patients undergoing primary percutaneous coronary intervention for ST-elevation acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Premedication; Prospective Studies; Recurrence; Registries; Retreatment; Stents; Thrombosis; Ticlopidine | 2008 |
Identification and characterization of a principal oxidation impurity in clopidogrel drug substance and drug product.
Topics: Clopidogrel; Drug Contamination; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Pharmaceutical Preparations; Platelet Aggregation Inhibitors; Spectrometry, Mass, Electrospray Ionization; Ticlopidine | 2008 |
Clinical outcomes after multilesion percutaneous coronary intervention: comparison between exclusive and selective use of drug-eluting stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Female; Follow-Up Studies; Health Care Costs; Humans; Male; Middle Aged; Patient Selection; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Quebec; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2008 |
Drug-eluting versus bare-metal stents: when and for whom?
Topics: Angioplasty, Balloon, Coronary; Canada; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Diabetes Complications; Drug-Eluting Stents; Health Care Costs; Humans; Patient Selection; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2008 |
[Prasugrel versus clopidogrel. From the American Heart Association meeting, 2007].
Topics: Clopidogrel; Congresses as Topic; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2008 |
Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack.
Topics: Aspirin; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Combinations; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2008 |
Trends in usage of alternative antiplatelet therapy after stroke and transient ischemic attack.
Topics: Aged; Aged, 80 and over; Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Prescriptions; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Marketing of Health Services; Middle Aged; Platelet Aggregation Inhibitors; Registries; Stroke; Ticlopidine; United States | 2008 |
The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Resistance; Female; Genotype; Humans; Korea; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2008 |
Antiplatelet therapy in acute coronary syndrome: not as confusing as you think.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass; Emergency Service, Hospital; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Effects of diabetes mellitus on platelet reactivity after dual antiplatelet therapy with aspirin and clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cohort Studies; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Very very late thrombosis of a sirolimus-eluting stent: does suboptimal stent expansion take its toll even after three years?
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Radiography; Reoperation; Sirolimus; Ticlopidine; Time Factors | 2008 |
Simultaneous subacute coronary drug-eluting stent thrombosis in two different vessels of a patient with factor V Leiden mutation.
Topics: Angioplasty, Balloon; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug-Eluting Stents; Factor V; Humans; Male; Middle Aged; Mutation; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Ticlopidine; Warfarin | 2008 |
Inhibition of ADP-induced platelet aggregation by clopidogrel is related to CYP2C19 genetic polymorphisms.
Topics: Adenosine Diphosphate; Adult; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2008 |
Resistance to what, does it matter? How do we study it?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug Resistance; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Point-of-Care Systems; Ticlopidine | 2008 |
[Intravitreal injections during anticoagulant treatment].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anticoagulants; Aspirin; Bevacizumab; Choroidal Neovascularization; Clopidogrel; Conjunctival Diseases; Humans; Injections; Intracranial Hemorrhages; Macular Degeneration; Phenprocoumon; Platelet Aggregation Inhibitors; Prospective Studies; Ranibizumab; Risk Factors; Ticlopidine; Triamcinolone; Vitreous Body; Vitreous Hemorrhage | 2008 |
A critically severe gingival bleeding following non-surgical periodontal treatment in patients medicated with anti-platelet.
Topics: Aspirin; Clopidogrel; Drug Combinations; Female; Gingival Hemorrhage; Humans; Middle Aged; Periodontitis; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Root Planing; Shock; Ticlopidine | 2008 |
Glycoprotein IIb-IIIa inhibitors in the emergency department for patients with non-ST-elevation acute coronary syndromes: principles and practices.
Topics: Acute Coronary Syndrome; Atherectomy; Clopidogrel; Emergency Service, Hospital; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Preoperative Care; Randomized Controlled Trials as Topic; Ticlopidine; Troponin | 2009 |
Prasugrel versus clopidogrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Stroke; Thiophenes; Ticlopidine | 2008 |
Prasugrel versus clopidogrel.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk; Thiophenes; Ticlopidine | 2008 |
Prasugrel versus clopidogrel.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Humans; Monitoring, Physiologic; Myocardial Infarction; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2008 |
Common blood thinners: what are the differences?
Topics: Anticoagulants; Aspirin; Clopidogrel; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Drug Utilization; Emergency Nursing; Emergency Service, Hospital; Humans; Monitoring, Physiologic; Risk Assessment; Sensitivity and Specificity; Ticlopidine; Warfarin | 2008 |
Severe anemia associated with transient ischemic attacks involving vertebrobasilar circulation.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anemia; Clopidogrel; Diagnosis, Differential; Electrocardiography; Humans; Hypoxia; Ischemic Attack, Transient; Male; Middle Aged; Pantoprazole; Platelet Aggregation Inhibitors; Ticlopidine; Ultrasonography, Doppler, Transcranial; Vertebrobasilar Insufficiency | 2008 |
Effects of continuous administration of clopidogrel before off-pump coronary artery bypass grafting in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Blood Transfusion; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Hemoglobins; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Retrospective Studies; Ticlopidine | 2008 |
The efficacy and safety of clopidogrel resinate as a novel polymeric salt form of clopidogrel.
Topics: Animals; Bleeding Time; Caco-2 Cells; Chemical Phenomena; Chemistry, Physical; Clopidogrel; Dogs; Drug Stability; Gastrointestinal Tract; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Male; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymers; Rats; Rats, Sprague-Dawley; Ticlopidine | 2008 |
Monitoring the efficacy of antiplatelet therapy: all methods are equal, but some methods are more equal than others?
Topics: Aspirin; Clopidogrel; Drug Monitoring; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Stents; Ticlopidine | 2008 |
Clinical, procedural, and pharmacologic correlates of acute and subacute stent thrombosis: results of a multicenter case-control study with 145 thrombosis events.
Topics: Acute Disease; Aged; Analysis of Variance; Case-Control Studies; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Factors; Stents; Ticlopidine | 2008 |
[Transient ischemic attack associated with a calcinosis cerebri syndrome].
Topics: Aged; Brain Diseases; Calcinosis; Clopidogrel; Dysarthria; Humans; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Platelet Aggregation Inhibitors; Ticlopidine; Tomography, X-Ray Computed | 2008 |
[Spinal cord ischaemia and preoperative clopidogrel withdrawal in an arteriosclerotic patient].
Topics: Arteriosclerosis; Clopidogrel; Female; Humans; Middle Aged; Platelet Aggregation Inhibitors; Spinal Cord Ischemia; Substance Withdrawal Syndrome; Ticlopidine | 2008 |
Oseltamivir, an anti-influenza virus drug, produces hypothermia in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Area Under Curve; Body Temperature; Clopidogrel; Diclofenac; Dose-Response Relationship, Drug; Hypothermia; Male; Mice; Oseltamivir; Platelet Aggregation Inhibitors; Ticlopidine; Zanamivir | 2008 |
Effect of CYP3A5*3 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects.
Topics: Adult; Clopidogrel; Cytochrome P-450 CYP3A; Genotype; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Will measuring vasodilator-stimulated phosphoprotein phosphorylation help us optimize the loading dose of clopidogrel?
Topics: Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Humans; Microfilament Proteins; Myocardial Infarction; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Ticlopidine; Vasodilation | 2008 |
Current challenges and directions in antithrombotic therapy.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Comparison of PD0348292, a selective factor Xa inhibitor, to antiplatelet agents for the inhibition of arterial thrombosis.
Topics: Administration, Oral; Animals; Aspirin; Bleeding Time; Blood Coagulation; Carotid Artery Injuries; Carotid Artery Thrombosis; Clopidogrel; Disease Models, Animal; Factor Xa Inhibitors; Female; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridones; Pyrrolidines; Sus scrofa; Thrombosis; Ticlopidine | 2008 |
Unilateral idiopathic adrenal hematomas with a preoperative diagnosis of indeterminate adrenal tumors.
Topics: Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenalectomy; Aged; Anemia; Aspirin; Clopidogrel; Coronary Artery Disease; Diagnosis, Differential; Female; Hematoma; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Retrospective Studies; Stents; Ticlopidine | 2008 |
Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Alleles; Body Mass Index; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Resistance; Female; Heterozygote; Humans; Male; Microfilament Proteins; Middle Aged; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prospective Studies; Ticlopidine | 2008 |
Bleeding complications in dermatologic surgery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Clopidogrel; Humans; Intraoperative Complications; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Skin Diseases; Ticlopidine; Warfarin | 2007 |
Stent thrombosis--a complication best avoided.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Heparin; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Risk Factors; Thrombectomy; Ticlopidine | 2008 |
Percutaneous coronary intervention in neurosurgical patients.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Thrombosis; Female; Humans; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2008 |
Resistance to platelet antiaggregants: an important cause of very late thrombosis of drug eluting stents? Observations from five cases.
Topics: Aged; Aged, 80 and over; Aspirin; Cell Adhesion Molecules; Clopidogrel; Coronary Thrombosis; Drug Resistance; Drug-Eluting Stents; Female; Fibrinolytic Agents; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine | 2008 |
[Influence of statins on the antiplatelet effect of clopidogrel and on cardiovascular outcome in patients after coronary intervention].
Topics: Atorvastatin; Clopidogrel; Coronary Disease; Coronary Stenosis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrroles; Simvastatin; Stents; Ticlopidine | 2008 |
Acute stent thrombosis in a patient with giant cell arteritis.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Thrombosis; Giant Cell Arteritis; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Prednisone; Stents; Ticlopidine | 2008 |
Platelet activation and atherothrombosis.
Topics: Acute Coronary Syndrome; Aspirin; Atherosclerosis; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Vascular Diseases | 2008 |
Operative delay for orthopedic patients on clopidogrel (plavix): a complete lack of consensus.
Topics: Adult; Clopidogrel; Emergency Treatment; Female; Fracture Fixation, Internal; Health Care Surveys; Hip Fractures; Humans; Internship and Residency; Male; Needs Assessment; Orthopedics; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Practice Patterns, Physicians'; Prognosis; Risk Assessment; Surveys and Questionnaires; Ticlopidine; Time Factors | 2008 |
[Antiplatelet treatment after acute and chronic ischemic heart and brain events is insufficient according to recommendations].
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angina, Unstable; Aspirin; Brain Infarction; Brain Ischemia; Clopidogrel; Diabetes Mellitus; Dipyridamole; Drug Therapy, Combination; Female; Guideline Adherence; Humans; Ischemic Attack, Transient; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Antithrombotic therapy in peripheral arterial disease.
Topics: Anticoagulants; Aspirin; Atherosclerosis; Cilostazol; Clopidogrel; Comorbidity; Diabetic Angiopathies; Humans; Hypertension; Intermittent Claudication; Pentoxifylline; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Risk Factors; Smoking; Tetrazoles; Thrombolytic Therapy; Ticlopidine | 2008 |
[Antithrombotic therapy in operations on extracranial arteries].
Topics: Aged; Brain Ischemia; Clopidogrel; Combined Modality Therapy; Endarterectomy, Carotid; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Postoperative Complications; Russia; Ticlopidine | 2008 |
What anti-thrombotic therapy is best with primary PCI for acute ST elevation myocardial infarction: how should the HORIZONS trial change current practice?
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Cardiovascular Diseases; Clopidogrel; Fibrinolytic Agents; Hemorrhage; Heparin; Hirudins; Humans; Myocardial Infarction; Patient Selection; Peptide Fragments; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Recombinant Proteins; Research Design; Stents; Thrombin; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Commentary for "Comparison of drug eluting stents with bare metal stents in unselected patients with acute myocardial infarction".
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Humans; Metals; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Prosthesis Design; Research Design; Secondary Prevention; Stents; Ticlopidine; Treatment Outcome | 2008 |
Innovations in bifurcations.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Humans; Patient Selection; Platelet Aggregation Inhibitors; Prosthesis Design; Research Design; Severity of Illness Index; Stents; Ticlopidine; Treatment Outcome; Ultrasonography, Interventional | 2008 |
Single antiplatelet therapy for patients with previous gastrointestinal bleeds.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Ticlopidine | 2008 |
Correction to the PRoFESS Trial paper by Diener et al. (Cerebrovasc Dis 2007;23:368-80.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Aspirin, Dipyridamole Drug Combination; Benzimidazoles; Benzoates; Clopidogrel; Data Interpretation, Statistical; Delayed-Action Preparations; Dipyridamole; Drug Combinations; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Telmisartan; Ticlopidine | 2008 |
Observance of antiplatelet therapy after stent implantation in patients under chronic oral anticoagulant treatment.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Drug Delivery Systems; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Patient Compliance; Platelet Aggregation Inhibitors; Stents; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Drug interaction with anti-mycobacterial treatment as a cause of clopidogrel resistance.
Topics: Abciximab; Aged; Antibiotics, Antitubercular; Antibodies, Monoclonal; Clopidogrel; Drug Interactions; Drug Resistance; Graft Occlusion, Vascular; Humans; Immunoglobulin Fab Fragments; Male; Mycobacterium avium-intracellulare Infection; Myocardial Infarction; Opportunistic Infections; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine | 2008 |
Consensus document on intermittent claudication from the Central European Vascular Forum 1st edition - Abano Terme (Italy) - May 2005 2nd revision - Portroz (Slovenia) September 2007.
Topics: Aspirin; Carotid Stenosis; Clopidogrel; Disease Progression; Exercise Test; Humans; Intermittent Claudication; Ischemia; Leg; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Ultrasonography, Doppler, Color | 2008 |
May-Thurner syndrome in a pediatric renal transplant recipient--case report and literature review.
Topics: Adolescent; Clopidogrel; Creatinine; Edema; Female; Graft Survival; Humans; Iliac Vein; Kidney Diseases; Kidney Transplantation; Lymphocele; Stockings, Compression; Syndrome; Ticlopidine; Treatment Outcome; Vascular Diseases | 2008 |
Glycoprotein IIb/IIIa receptor inhibition with abciximab during percutaneous coronary interventions increases the risk of bleeding in patients with impaired renal function.
Topics: Abciximab; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Germany; Glomerular Filtration Rate; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Renal Insufficiency; Retrospective Studies; Surveys and Questionnaires; Survival Analysis; Ticlopidine | 2008 |
Bleeding risks with prasugrel in the TRITON trial: good news ... bad news.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Therapy, Combination; Hematemesis; Hematuria; Hemorrhage; Humans; Intracranial Hemorrhages; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2008 |
Excess rates of nonfatal myocardial infarction in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel (preventing clinical events or chasing enzymatic ghosts?).
Topics: Clinical Trials, Phase III as Topic; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Multicenter Studies as Topic; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine; Treatment Outcome | 2008 |
A perspective on the efficacy and safety of intensive antiplatelet therapy in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infarction 38.
Topics: Clinical Trials, Phase III as Topic; Clopidogrel; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Humans; Multicenter Studies as Topic; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Research Design; Thiophenes; Ticlopidine; Treatment Outcome | 2008 |
A new self-expandable nitinol stent for the treatment of wide-neck aneurysms: initial clinical experience.
Topics: Adult; Aged; Alloys; Aneurysm, Ruptured; Aspirin; Cerebral Angiography; Clopidogrel; Combined Modality Therapy; Computer Simulation; Embolization, Therapeutic; Equipment Design; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Premedication; Retreatment; Stents; Subarachnoid Hemorrhage; Ticlopidine | 2008 |
The economic consequences of non-evidence-based clopidogrel use.
Topics: Aged; Aged, 80 and over; Clinical Trials as Topic; Clopidogrel; Cohort Studies; Evidence-Based Medicine; Female; Humans; Male; Medicare; Pennsylvania; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Quality of Health Care; Retrospective Studies; Ticlopidine; United States; Vascular Diseases | 2008 |
Plasma clopidogrel metabolites and antiplatelet "resistance": back to the future.
Topics: Clopidogrel; Drug Resistance; Humans; Medication Adherence; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Anti-platelet agents and surgical delay in elderly patients with hip fractures.
Topics: Aged; Aspirin; Bleeding Time; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Hip Fractures; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Impaired bioavailability of clopidogrel in patients with a ST-segment elevation myocardial infarction.
Topics: Adult; Aged; Biological Availability; Clopidogrel; Electrocardiography; Female; Humans; Intestinal Absorption; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
[Media and ethics: misunderstood requirement?].
Topics: Cardiovascular Diseases; Clopidogrel; Communications Media; Drug Industry; Drug Prescriptions; France; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Effect of clopidogrel on bleeding and transfusions after off-pump coronary artery bypass graft surgery: impact of discontinuation prior to surgery.
Topics: Aged; Analysis of Variance; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass, Off-Pump; Drug Administration Schedule; Humans; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Prospective Studies; Risk Factors; Ticlopidine | 2008 |
Postcatheterization femoral artery pseudoaneurysms: therapeutic options. A case-controlled study.
Topics: Adult; Aged; Aneurysm, False; Anticoagulants; Case-Control Studies; Catheterization, Peripheral; Clopidogrel; Female; Femoral Artery; Hemostatic Techniques; Hemostatics; Humans; Injections, Intra-Arterial; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Thrombin; Ticlopidine; Ultrasonography, Doppler, Color; Ultrasonography, Interventional | 2008 |
Gastro-intestinal haemorrhage risks of selective serotonin receptor antagonist therapy: a new look.
Topics: Aged; Aged, 80 and over; Anticoagulants; Antidepressive Agents; Case-Control Studies; Clopidogrel; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Selective Serotonin Reuptake Inhibitors; Ticlopidine; Warfarin | 2008 |
Drug-eluting stent implantation for acute myocardial infarction during pregnancy with use of glycoprotein IIb/IIIa inhibitor, aspirin and clopidogrel.
Topics: Aspirin; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Electrocardiography; Female; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pregnancy; Pregnancy Complications, Cardiovascular; Prosthesis Implantation; Ticlopidine; Treatment Outcome | 2008 |
P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.
Topics: Adenosine Monophosphate; Administration, Oral; Animals; Clopidogrel; Hyperesthesia; Injections, Spinal; Male; Membrane Proteins; Mice; Mice, Knockout; Microglia; Neuralgia; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Spinal Cord; Spinal Nerves; Ticlopidine; Up-Regulation | 2008 |
Aspirin non-responsiveness in Korean subjects on dual anti-platelet treatment determined by two different platelet function assays.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Asian People; Aspirin; Bleeding Time; Case-Control Studies; Clopidogrel; Collagen; Drug Resistance; Epinephrine; Female; Humans; Korea; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2008 |
Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes.
Topics: Appetite Depressants; Aryl Hydrocarbon Hydroxylases; Catalysis; Clopidogrel; Cyclobutanes; Cytochrome P-450 CYP2B6; DNA, Complementary; Humans; Microsomes, Liver; Oxidoreductases, N-Demethylating; Ticlopidine | 2008 |
Randomized trials in hemodialysis patients: time to step up to the plate.
Topics: Arteriovenous Shunt, Surgical; Clopidogrel; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Renal Dialysis; Ticlopidine | 2008 |
Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Treatment Outcome | 2008 |
Clopidogrel resistance: more grist for the mill.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2008 |
Dual antiplatelet therapy monitoring for neurointerventional procedures using a point-of-care platelet function test: a single-center experience.
Topics: Adult; Aged; Angioplasty, Balloon; Aspirin; Cerebrovascular Disorders; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Embolization, Therapeutic; Female; Humans; Intracranial Embolism; Intracranial Thrombosis; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Stents; Ticlopidine | 2008 |
The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Cells, Cultured; Clopidogrel; Drug Interactions; Humans; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2008 |
Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Clopidogrel; Drug Resistance; Female; Haplotypes; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Young Adult | 2009 |
[Emergency treatment of transient cerebral ischemia].
Topics: Aspirin; Clopidogrel; Emergency Treatment; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine | 2008 |
Pharmacoeconomic concepts in antiplatelet therapy: understanding cost-effectiveness analyses using clopidogrel as an example.
Topics: Acute Coronary Syndrome; Clopidogrel; Cost-Benefit Analysis; Costs and Cost Analysis; Economics, Pharmaceutical; Humans; Models, Economic; Platelet Aggregation Inhibitors; Terminology as Topic; Ticlopidine | 2008 |
Relationship between aspirin and clopidogrel responses in acute coronary syndrome and clinical predictors of non response.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Arachidonic Acid; Aspirin; Body Mass Index; Cell Adhesion Molecules; Clopidogrel; Diabetes Complications; Drug Resistance; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
For better or for worse: the future of antiplatelet therapy.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Disease; Forecasting; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stroke; Thiophenes; Thrombolytic Therapy; Thrombosis; Ticlopidine | 2008 |
Spontaneous ovarian hematoma in a patient treated with clopidogrel.
Topics: Adult; Clopidogrel; Female; Hematoma; Humans; Ovarian Cysts; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Routine pre-treatment with clopidogrel before diagnostic coronary angiography: the question is right, but what about the answer?
Topics: Angina Pectoris; Clopidogrel; Coronary Angiography; Humans; Platelet Aggregation Inhibitors; Premedication; Randomized Controlled Trials as Topic; Ticlopidine | 2008 |
Statins do not adversely affect post-interventional residual platelet aggregation and outcomes in patients undergoing coronary stenting treated by dual antiplatelet therapy.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Stenosis; Cytochrome P-450 CYP3A; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Stents; Ticlopidine | 2008 |
Adverse events associated with stopping clopidogrel after acute coronary syndrome.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2008 |
Adverse events associated with stopping clopidogrel after acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2008 |
2007 focused update to the ACC/AHA guidelines for the management of patients with ST-segment elevation myocardial infarction: implications for emergency department practice.
Topics: Angioplasty, Balloon, Coronary; Cardiology; Clopidogrel; Emergency Service, Hospital; Enoxaparin; Evidence-Based Medicine; Fibrinolytic Agents; Humans; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Societies, Medical; Ticlopidine; United States | 2008 |
Multiple electrode aggregometry and P2Y(12) antagonists.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Anticoagulants; Clopidogrel; Dose-Response Relationship, Drug; Electrodes; Equipment Design; Hirudins; Humans; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2008 |
Chronic total occlusion--use of a 5 French guiding catheter in a 6 French guiding catheter.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Occlusion; Coronary Restenosis; Coronary Vessels; Humans; Male; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2008 |
Antiaggregant and anticoagulant therapy of free-floating thrombus in left atrium.
Topics: Adult; Anticoagulants; Aspirin; Clopidogrel; Diagnosis, Differential; Dyspnea; Echocardiography, Transesophageal; Female; Heart Atria; Heart Diseases; Heparin; Humans; Platelet Aggregation Inhibitors; Radiography; Thrombosis; Ticlopidine; Warfarin | 2008 |
The common gene variants of CYP2C19 affect pharmacokinetics and pharmacodynamics in an active metabolite of clopidogrel in healthy subjects.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Variation; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2008 |
Long-term outcomes by clopidogrel duration and stent type in a diabetic population with de novo coronary artery lesions.
Topics: Clopidogrel; Coronary Artery Disease; Diabetes Mellitus; Disease Progression; Drug-Eluting Stents; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Survival Analysis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
The evolution of thienopyridine therapy clopidogrel duration, diabetes, and drug-eluting stents.
Topics: Clopidogrel; Coronary Artery Disease; Diabetes Mellitus; Disease Progression; Drug-Eluting Stents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
[Dual antiplatelet drug resistance in a patient allergic to clopidogrel: a case report].
Topics: Aged; Aspirin; Clopidogrel; Drug Resistance; Female; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2008 |
Unplanned surgery after drug eluting stent implantation: a strategy for safe temporary withdrawal of dual oral antiplatelet therapy.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Contraindications; Drug Therapy, Combination; Drug-Eluting Stents; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Preoperative Care; Surgical Procedures, Operative; Ticlopidine; Tirofiban; Tyrosine | 2008 |
Cost-effectiveness of clopidogrel treatment in percutaneous coronary intervention: a European model based on a meta-analysis of the PCI-CURE, CREDO and PCI-CLARITY trials.
Topics: Aged; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Cost-Benefit Analysis; Europe; Humans; Markov Chains; Meta-Analysis as Topic; Middle Aged; Models, Statistical; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2008 |
Relation of low response to clopidogrel assessed with point-of-care assay to periprocedural myonecrosis in patients undergoing elective coronary stenting for stable angina pectoris.
Topics: Aged; Angina Pectoris; Aspirin; Clopidogrel; Confidence Intervals; Elective Surgical Procedures; Female; Follow-Up Studies; Humans; Incidence; Male; Myocardial Infarction; Myocardial Revascularization; Odds Ratio; Platelet Aggregation Inhibitors; Point-of-Care Systems; Preoperative Care; Prospective Studies; Risk Factors; Stents; Ticlopidine; Treatment Outcome; Troponin T | 2008 |
Clopidogrel pretreatment abolishes increase of PAI-1 after coronary stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; C-Reactive Protein; Clopidogrel; Female; Humans; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Tissue Plasminogen Activator | 2008 |
Current practice of antithrombotic treatment in ischemic stroke: a survey among Hungarian neurologists.
Topics: Adult; Aged; Anticoagulants; Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Prescriptions; Drug Therapy, Combination; Female; Fibrinolytic Agents; Health Care Surveys; Humans; Hungary; Male; Middle Aged; Neurology; Platelet Aggregation; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Stroke; Surveys and Questionnaires; Ticlopidine | 2008 |
Safety and efficacy of clopidogrel in children with heart disease.
Topics: Adolescent; Aspirin; Child; Child, Preschool; Clopidogrel; Female; Heart Diseases; Hemorrhage; Humans; Infant; Infant, Newborn; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Warfarin | 2008 |
Overview of advances in cardiovascular disease treatment and prevention: the evolving role of antiplatelet therapy.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clinical Protocols; Clopidogrel; Drug Therapy; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; United States | 2008 |
The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Evidence-Based Medicine; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Injections, Subcutaneous; Perioperative Care; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine; Treatment Outcome; Vitamin K | 2008 |
Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Topics: Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Evidence-Based Medicine; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Injections, Intravenous; Injections, Subcutaneous; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Stroke; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator | 2008 |
Antithrombotic therapy for non-ST-segment elevation acute coronary syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Electrocardiography; Fibrinolytic Agents; Fondaparinux; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Polysaccharides; Risk Assessment; Risk Factors; Ticlopidine; Tirofiban; Tyrosine | 2008 |
The primary and secondary prevention of coronary artery disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Evidence-Based Medicine; Fibrinolytic Agents; Humans; Primary Prevention; Risk Assessment; Risk Factors; Ticlopidine | 2008 |
[ASS plus dipyridamole or clopidogrel after stroke: what is the best secondary prevention?].
Topics: Aspirin; Cerebral Infarction; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Germany; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Secondary Prevention; Ticlopidine | 2008 |
2007 Guideline update for unstable angina/non-ST-segment elevation myocardial infarction: focus on antiplatelet and anticoagulant therapies.
Topics: American Heart Association; Angina, Unstable; Anticoagulants; Clopidogrel; Drug-Eluting Stents; Enoxaparin; Fondaparinux; Heparin; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polysaccharides; Practice Guidelines as Topic; Recombinant Proteins; Ticlopidine; United States | 2008 |
Coexisting polymorphisms of P2Y12 and CYP2C19 genes as a risk factor for persistent platelet activation with clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine | 2008 |
Upper gastrointestinal bleeding in patients with aspirin and clopidogrel co-therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Odds Ratio; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
[Secondary stroke prevention according to the PRoFESS Study. What are the sequelae for practical therapy?].
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Germany; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Recurrence; Stroke; Ticlopidine | 2008 |
Very late stent thrombosis after drug-eluting stent implantation in a patient without aspirin and clopidogrel resistance.
Topics: Aged; Angina Pectoris; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Resistance; Drug-Eluting Stents; Electrocardiography; Female; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2008 |
Explanations for variations in clopidogrel prescribing in England.
Topics: Cardiovascular Diseases; Clopidogrel; Drug Prescriptions; England; Health Expenditures; Humans; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Primary Health Care; Regression Analysis; State Medicine; Ticlopidine | 2008 |
Clopidogrel but not Aspirin prevents acute smoking-induced platelet aggregation in patients with stable coronary artery disease.
Topics: Adult; Aspirin; Clopidogrel; Coronary Artery Disease; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Smoking; Ticlopidine | 2009 |
Comparison of stent thrombosis, myocardial infarction, and mortality following drug-eluting versus bare-metal stent coronary intervention in patients with diabetes mellitus.
Topics: Aged; Aspirin; Clopidogrel; Denmark; Diabetes Complications; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2008 |
Benefit of clopidogrel for acute coronary syndrome and percutaneous coronary interventions in doubt due to rebound adverse events.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Elevated coronary calcium scores are associated with higher residual platelet aggregation after clopidogrel treatment in patients with stable angina pectoris.
Topics: Aged; Angina Pectoris; Calcium; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardium; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Lack of early augmentation of platelet reactivity after coronary intervention in patients treated with bivalirudin.
Topics: Adenosine Diphosphate; Angina Pectoris; Anticoagulants; Aspirin; Cardiac Catheterization; Clopidogrel; Elective Surgical Procedures; Hemostatics; Hirudins; Humans; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Period; Recombinant Proteins; Thrombin; Ticlopidine; Time Factors | 2009 |
Antiplatelet therapy in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Monophosphate; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2008 |
Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery disease.
Topics: Aged; Aspirin; Baltimore; Biomarkers; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2008 |
Efficient tirofiban infusion resulting in resolution of intracoronary thrombus.
Topics: Anticholesteremic Agents; Aspirin; Atorvastatin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Combination; Electrocardiography; Fibrinolytic Agents; Heptanoic Acids; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine; Tirofiban; Tyrosine | 2008 |
[Commentary to the article: Wiviott S D, Braunwald E, McCabe C H et al. Prasugrel versus clopidogrel in patients with acute coronary syndrome. N Engl J Med 2007; 357: 2001-15].
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Treatment Outcome | 2008 |
Effects of rosuvastatin on platelet inhibition by clopidogrel in cardiovascular patients.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Pyrimidines; Retrospective Studies; Rosuvastatin Calcium; Sulfonamides; Ticlopidine | 2009 |
Increased major bleeding complications related to triple antithrombotic therapy usage in patients with atrial fibrillation undergoing percutaneous coronary artery stenting.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Warfarin | 2008 |
Arterial antithrombotic and bleeding time effects of apixaban, a direct factor Xa inhibitor, in combination with antiplatelet therapy in rabbits.
Topics: Animals; Aspirin; Bleeding Time; Carotid Artery Thrombosis; Clopidogrel; Drug Therapy, Combination; Factor Xa Inhibitors; Fibrinolytic Agents; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Rabbits; Ticlopidine; Treatment Outcome | 2008 |
Clopidogrel therapy--implications for hip fracture surgery.
Topics: Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Drug Administration Schedule; Follow-Up Studies; Hemoglobins; Hip Fractures; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine; Time Factors | 2008 |
Reversible clopidogrel resistance due to right ventricular myocardial infarction: risk factor of recurrent stent thrombosis?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Electrocardiography; Enoxaparin; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Ticlopidine; Time Factors; Tirofiban; Treatment Outcome; Tyrosine; Ventricular Dysfunction, Right | 2008 |
[Impact of preoperative clopidogrel in coronary artery bypass grafting].
Topics: Aged; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Retrospective Studies; Ticlopidine; Treatment Outcome | 2008 |
The association of cigarette smoking with enhanced platelet inhibition by clopidogrel.
Topics: Adenosine Diphosphate; Adult; Aged; Clopidogrel; Cytochrome P-450 CYP1A2; Female; Flow Cytometry; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Proportional Hazards Models; Smoking; Stents; Ticlopidine | 2008 |
Antiplatelet therapy for patients with stents.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2008 |
Incidence and causes of new-onset dyspnea in 3,719 patients treated with clopidogrel and aspirin combination after coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Dyspnea; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Registries; Risk Factors; Stents; Surveys and Questionnaires; Thrombosis; Ticlopidine | 2008 |
Haemorrhagic herpes zoster associated with clopidogrel treatment.
Topics: Clopidogrel; Female; Hemorrhage; Herpes Zoster; Humans; Middle Aged; Platelet Aggregation Inhibitors; Skin Diseases, Vesiculobullous; Ticlopidine | 2009 |
Hydrolysis of adenine nucleotides in platelets from patients with acute myocardial infarction.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Female; Humans; Hydrolysis; Male; Middle Aged; Myocardial Infarction; Ticlopidine | 2008 |
Letter by Caruthers and Dorsch regarding article, "Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the platelet inhibition in children on cLOpidogrel (PICOLO) trial".
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Clopidogrel; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Humans; Infant; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
How long do I have to stay on Plavix after getting a drug-eluting stent?
Topics: Angioplasty, Balloon; Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2008 |
Why is the use of clopidogrel increasing rapidly in Australia? An exploration of geographical location, age, sex and cardiac stenting rates as possible influences on clopidogrel use.
Topics: Age Factors; Angioplasty, Balloon, Coronary; Australia; Clopidogrel; Drug Utilization; Female; Humans; Linear Models; Male; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Residence Characteristics; Sex Factors; Stents; Ticlopidine; Time Factors; Urban Health Services | 2008 |
Evaluation of triple anti-platelet therapy by modified thrombelastography in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Thrombelastography; Ticlopidine; Tirofiban; Tyrosine | 2008 |
Clopidogrel and bleeding after general surgery procedures.
Topics: Aged; Blood Loss, Surgical; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Premedication; Retrospective Studies; Risk Factors; Ticlopidine | 2008 |
The PRoFESS trial results: what went wrong?
Topics: Aspirin; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2008 |
CHARISMA revisited: is the glass half full or just empty?
Topics: Aspirin; Clopidogrel; Coronary Disease; Disease Progression; Humans; Platelet Aggregation Inhibitors; Primary Prevention; Randomized Controlled Trials as Topic; Registries; Stroke; Ticlopidine | 2008 |
Secondary stroke prevention with antiplatelet drugs: have we reached the ceiling?
Topics: Age Factors; Aged; Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Risk Assessment; Stroke; Ticlopidine; Time Factors | 2006 |
Very late stent thrombosis after discontinuation of clopidogrel therapy.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Stenosis; Coronary Thrombosis; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Prosthesis Failure; Radiography; Stents; Ticlopidine; Time Factors | 2008 |
Post-PCI fatal bleeding in aspirin and clopidogrel hyper responder: shifting from antiplatelet resistance to bleeding risk assessment?
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Clopidogrel; Fatal Outcome; Female; Humans; Intracranial Hemorrhages; Middle Aged; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2010 |
Intensive antiplatelet therapy for reduction of ischaemic events.
Topics: Clopidogrel; Humans; Myocardial Ischemia; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine; Time Factors | 2008 |
Aspirin resistance an underestimated risk in patients with drug-eluting stents?
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Resistance; Drug-Eluting Stents; Graft Occlusion, Vascular; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2008 |
Adjusting clopidogrel loading doses according to vasodilator-stimulated phosphoprotein index: on time, too early, or too late?
Topics: Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Microfilament Proteins; Myocardial Ischemia; Phosphoproteins; Platelet Aggregation Inhibitors; Predictive Value of Tests; Ticlopidine | 2008 |
Effectiveness of reloading to overcome clopidogrel nonresponsiveness in patients with acute myocardial infarction.
Topics: Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Electrocardiography; Female; Fibrinogen; Flow Cytometry; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2008 |
Interactions between multiple cell types in parallel microfluidic channels: monitoring platelet adhesion to an endothelium in the presence of an anti-adhesion drug.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Cattle; Cells, Cultured; Clopidogrel; Drug Evaluation, Preclinical; Endothelium, Vascular; Microfluidic Analytical Techniques; NG-Nitroarginine Methyl Ester; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Rabbits; Ticlopidine | 2008 |
[Resistance to antiplatelet drugs in patients with non ST elevation acute coronary syndrome].
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Disease; Drug Resistance; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Severity of Illness Index; Syndrome; Ticlopidine; Treatment Outcome | 2008 |
Stroke prevention--insights from incoherence.
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Benzimidazoles; Benzoates; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk; Secondary Prevention; Stroke; Telmisartan; Ticlopidine | 2008 |
Percutaneous treatment of a coronary aneurysm by stent graft and drug-eluting stent implantation: a potential method to reduce stent graft restenosis.
Topics: Aged; Clopidogrel; Coronary Aneurysm; Coronary Restenosis; Drug-Eluting Stents; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Safety and efficacy of low-dose clopidogrel in Japanese patients undergoing coronary stenting: preliminary 30-day clinical outcome.
Topics: Aged; Aspirin; Clopidogrel; Coronary Disease; Coronary Restenosis; Coronary Thrombosis; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Safety; Stents; Ticlopidine; Treatment Outcome | 2008 |
Comment: Aspirin, clopidogrel, and warfarin: is the combination appropriate and effective or inappropriate and too dangerous?
Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Warfarin | 2008 |
Acute arthritis associated with loading dose of clopidogrel.
Topics: Aged; Arthritis; Clopidogrel; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
[Secondary prevention with clopidogrel or acetylsalicylic acid after acute cerebrovascular event. Health services research study of private primary care specialists].
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Comorbidity; Cross-Sectional Studies; Female; Germany; Guideline Adherence; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Primary Health Care; Prospective Studies; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2008 |
Clopidogrel treatment and the MEND-CABG II trial.
Topics: Clopidogrel; Coronary Artery Bypass; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Platelet Aggregation Inhibitors; Purinergic Antagonists; Pyridoxal Phosphate; Risk; Ticlopidine | 2008 |
Dynamics of platelet functional recovery following a clopidogrel loading dose in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Clopidogrel; Drug Monitoring; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Point-of-Care Systems; Recovery of Function; Ticlopidine | 2008 |
Survival benefit with concomitant oral platelet therapy after coronary angiography and before ad hoc percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Complications; Severity of Illness Index; Survival Analysis; Ticlopidine; Treatment Outcome | 2008 |
Survival benefit with concomitant clopidogrel and glycoprotein IIb/IIIa inhibitor therapy at ad hoc percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Confidence Intervals; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Complications; Severity of Illness Index; Survival Analysis; Ticlopidine; Treatment Outcome | 2008 |
Clopidogrel in a pediatric population: prescribing practice and outcomes from a single center.
Topics: Adolescent; Child; Child Welfare; Child, Preschool; Clopidogrel; Coronary Thrombosis; Drug Prescriptions; Female; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Male; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Retrospective Studies; Ticlopidine; Treatment Outcome | 2009 |
Complications of needle electromyography: hematoma risk and correlation with anticoagulation and antiplatelet therapy.
Topics: Adult; Aged; Anticoagulants; Aspirin; Clopidogrel; Electrodes; Electrodiagnosis; Electromyography; Female; Hematoma; Humans; Incidence; Male; Middle Aged; Muscle, Skeletal; Needles; Patient Selection; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Ultrasonography | 2008 |
Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors.
Topics: Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2008 |
[Prasugrel versus Clopidogrel in patients with acute coronary syndromes. Results of the TRITON-TIMI 38 trial].
Topics: Acute Coronary Syndrome; Clopidogrel; Double-Blind Method; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2008 |
What to do with patients receiving long-term clopidogrel: reload or relax?
Topics: Clopidogrel; Coronary Thrombosis; Drug Administration Schedule; Humans; Platelet Aggregation; Randomized Controlled Trials as Topic; Relaxation; Ticlopidine; Time | 2008 |
Utility of the PFA-100 instrument and the novel multiplate analyzer for the assessment of aspirin and clopidogrel effects on platelet function in patients with cardiovascular disease.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Collagen; Electric Impedance; Epinephrine; Female; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Activation; Platelet Function Tests; Sensitivity and Specificity; Ticlopidine | 2009 |
Management and outcome of peptic ulcers or erosions in patients receiving a combination of aspirin plus clopidogrel.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Disease; Female; Gastrointestinal Hemorrhage; Hemostasis, Endoscopic; Hospitalization; Humans; Male; Peptic Ulcer; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2008 |
[Inhibition of platelet aggregation and angiotensin II-receptor blockade following TIA; the unexpected results of the Prevention Regimen For Effectively Avoiding Second Strokes (PROFESS) trial].
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Aspirin; Benzimidazoles; Benzoates; Clopidogrel; Cost-Benefit Analysis; Dipyridamole; Headache; Humans; Platelet Aggregation Inhibitors; Stroke; Telmisartan; Ticlopidine | 2008 |
Recurrent myocardial infarction in a young football player with antithrombin III deficiency.
Topics: Angioplasty, Balloon, Coronary; Antithrombin III Deficiency; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Football; Humans; Male; Myocardial Infarction; Myocardial Perfusion Imaging; Physical Fitness; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine; Young Adult | 2008 |
Anticoagulant and/or antiplatelet treatment in patients with atrial fibrillation after percutaneous coronary intervention. A single-center experience.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Heparin, Low-Molecular-Weight; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
[Upper gastrointestinal bleeding associated with clopidogrel and paroxetine].
Topics: Aged; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Male; Paroxetine; Platelet Aggregation Inhibitors; Selective Serotonin Reuptake Inhibitors; Ticlopidine | 2008 |
[Severe myocardial infarction due to late and very late stent thrombosis after coronary artery stenting with drug-eluting stents].
Topics: Aged; Aspirin; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Creatine Kinase; Drug-Eluting Stents; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Initiation and persistence with clopidogrel treatment after acute myocardial infarction: a nationwide study.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Confidence Intervals; Denmark; Female; Humans; Male; Middle Aged; Myocardial Infarction; Patient Compliance; Platelet Aggregation Inhibitors; Prescriptions; Proportional Hazards Models; Registries; Sex Factors; Ticlopidine | 2008 |
Dual antiplatelet therapy unmasks distinct platelet reactivity in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Aspirin; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2008 |
Quantitative determination of clopidogrel active metabolite in human plasma by LC-MS/MS.
Topics: Adolescent; Adult; Aged; Area Under Curve; Calibration; Chromatography, Liquid; Clopidogrel; Drug Stability; Female; Freezing; Humans; Male; Metabolic Clearance Rate; Middle Aged; Molecular Structure; Platelet Aggregation Inhibitors; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Ticlopidine; Time Factors; Young Adult | 2008 |
Late outcomes after drug-eluting stent implantation in "real-world" clinical practice.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Unprotected left main coronary artery bifurcation stenosis: impact of plaque debulking prior to single sirolimus-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Drug-Eluting Stents; Feasibility Studies; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Sirolimus; Ticlopidine | 2008 |
Treatment of patients with cardiogenic shock in the setting of acute myocardial infarction. Case reports.
Topics: Aged; Angioplasty, Balloon; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carbazoles; Carvedilol; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Propanolamines; Shock, Cardiogenic; Stents; Ticlopidine; Vasodilator Agents | 2008 |
Effect of clopidogrel on arteriovenous fistulas for dialysis.
Topics: Arteriovenous Shunt, Surgical; Clopidogrel; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Renal Dialysis; Ticlopidine | 2008 |
Effect of clopidogrel on arteriovenous fistulas for dialysis.
Topics: Arteriovenous Shunt, Surgical; Clopidogrel; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombosis; Ticlopidine | 2008 |
Effect of clopidogrel on arteriovenous fistulas for dialysis.
Topics: Arteriovenous Shunt, Surgical; Clopidogrel; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombosis; Ticlopidine | 2008 |
Dyspnea and antiplatelet drugs: little cause for concern with clopidogrel.
Topics: Clopidogrel; Dyspnea; Humans; Platelet Aggregation Inhibitors; Safety; Ticlopidine | 2008 |
Identifying clopidogrel resistance during chronic therapy: the case for a biochemical approach.
Topics: Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2008 |
Overcoming "resistance" to aspirin and clopidogrel with tirofiban: fact or fiction?
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Tirofiban; Tyrosine | 2008 |
The impact of preinjury antiplatelet and anticoagulant pharmacotherapy on outcomes in elderly patients with hemorrhagic brain injury.
Topics: Age Factors; Aged; Anticoagulants; Aspirin; Brain Hemorrhage, Traumatic; Cardiovascular Diseases; Cause of Death; Clopidogrel; Cohort Studies; Comorbidity; Female; Follow-Up Studies; Geriatric Assessment; Hospital Mortality; Humans; Injury Severity Score; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Retrospective Studies; Risk Assessment; Sex Factors; Survival Analysis; Ticlopidine; Trauma Centers; Treatment Outcome; Warfarin; Wounds, Nonpenetrating | 2008 |
Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel.
Topics: Aged; Body Mass Index; Cardiovascular Diseases; Clopidogrel; Diabetes Complications; Female; Fibrinogen; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine | 2008 |
Predictors of mortality in trauma patients with intracranial hemorrhage on preinjury aspirin or clopidogrel.
Topics: Administration, Oral; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Coagulation Tests; Brain Injuries; Case-Control Studies; Cause of Death; Clopidogrel; Female; Geriatric Assessment; Glasgow Coma Scale; Hospital Mortality; Humans; Intracranial Hemorrhages; Male; Middle Aged; Multiple Trauma; Predictive Value of Tests; Probability; Prognosis; Reference Values; Retrospective Studies; Risk Assessment; Survival Analysis; Ticlopidine; Tomography, X-Ray Computed; Trauma Centers | 2008 |
Repeated high doses of clopidogrel in 2 cases of pharmacological resistance.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Administration Schedule; Drug Resistance; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Treatment Failure | 2008 |
[Thrombocyte aggregation inhibitor after surgery for an abdominal aortic aneurysm].
Topics: Aortic Aneurysm, Abdominal; Arteriosclerosis; Aspirin; Blood Vessel Prosthesis Implantation; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Care; Risk Factors; Thrombosis; Ticlopidine | 2008 |
Outcomes after percutaneous coronary intervention in contemporary Australian practice: insights from a large multicentre registry.
Topics: Acute Coronary Syndrome; Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Comorbidity; Drug-Eluting Stents; Female; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Registries; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome; Victoria | 2008 |
Optimizing clopidogrel therapy before stent implantation: should clinical setting be taken into account?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Severity of Illness Index; Stents; Ticlopidine; Treatment Outcome | 2008 |
ExTRACT-TIMI 25 in perspective: key lessons regarding enoxaparin as an adjunct to fibrinolytic therapy.
Topics: Aged; Anticoagulants; Clopidogrel; Combined Modality Therapy; Comorbidity; Disease-Free Survival; Drug Therapy, Combination; Enoxaparin; Female; Fibrinolytic Agents; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Randomized Controlled Trials as Topic; Recurrence; Risk Assessment; Stroke; Thrombolytic Therapy; Ticlopidine | 2009 |
[Is this case really the one of clopidogrel-associated thrombotic thrombocytopenic purpura?].
Topics: Clopidogrel; Humans; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2008 |
Cardiovascular outcomes after a change in prescription policy for clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Health Policy; Hemorrhage; Humans; Insurance Benefits; Insurance, Health, Reimbursement; Insurance, Pharmaceutical Services; Male; Myocardial Infarction; National Health Programs; Ontario; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Recurrence; Stents; Ticlopidine | 2008 |
Short- and long-term efficacy of aspirin and clopidogrel for thromboprophylaxis for mechanical heart valves: an in vivo study in swine.
Topics: Administration, Oral; Animals; Aspirin; Bioprosthesis; Clopidogrel; Dalteparin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart Valve Prosthesis Implantation; Injections, Subcutaneous; Postoperative Care; Postoperative Complications; Random Allocation; Risk Factors; Sensitivity and Specificity; Statistics, Nonparametric; Survival Rate; Swine; Thromboembolism; Thrombolytic Therapy; Ticlopidine; Time Factors | 2008 |
The challenge of monitoring platelet response after clopidogrel.
Topics: Blood Platelets; Clopidogrel; Coronary Disease; Coronary Thrombosis; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2008 |
Reproducibility and standardized reporting of the vasodilator-stimulated phosphoprotein phosphorylation assay.
Topics: Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Flow Cytometry; Humans; Indicators and Reagents; Microfilament Proteins; Observer Variation; Phosphoproteins; Phosphorylation; Platelet Function Tests; Reagent Kits, Diagnostic; Reference Standards; Reproducibility of Results; Ticlopidine | 2008 |
[Acute coronary syndrome -- long term protection by dual thrombocyte aggregation inhibition during twelve months].
Topics: Acute Coronary Syndrome; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Follow-Up Studies; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Stents; Ticlopidine; Time Factors; Troponin | 2008 |
Studies on the role of the extracellular cysteines and oligomeric structures of the P2Y12 receptor when interacting with antagonists.
Topics: Blood Platelets; Clopidogrel; Cysteine; Dimerization; Humans; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2009 |
Antithrombotic effect of clopidogrel in a vena cava thrombosis model in obese mice.
Topics: Animals; Clopidogrel; Dietary Fats; Disease Models, Animal; Fibrinolytic Agents; Mice; Mice, Obese; Ticlopidine; Venae Cavae; Venous Thrombosis | 2009 |
Adrenoreceptors, platelet reactivity and clopidogrel resistance.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Humans; Norepinephrine; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Failure | 2008 |
Pro: 'Antithrombotic therapy with warfarin, aspirin and clopidogrel is the recommended regime in anticoagulated patients who present with an acute coronary syndrome and/or undergo percutaneous coronary interventions'.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Thrombosis; Ticlopidine; Warfarin | 2008 |
Contra: 'Antithrombotic therapy with warfarin, aspirin and clopidogrel is the recommended regimen in anticoagulated patients who present with an acute coronary syndrome and/or undergo percutaneous coronary interventions'. Not for everybody.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Thrombosis; Ticlopidine; Warfarin | 2008 |
Analysis of platelet alpha2-adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adrenergic alpha-Antagonists; Aged; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Humans; Imidazoles; Male; Middle Aged; Norepinephrine; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Failure | 2008 |
Impact of a 600-mg loading dose of clopidogrel on 30-day outcome in unselected patients undergoing percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors | 2008 |
Patterns of upstream antiplatelet therapy use before primary percutaneous coronary intervention for acute ST-elevation myocardial infarction (from the CRUSADE National Quality Improvement Initiative).
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Retrospective Studies; Ticlopidine | 2008 |
Measurement of the platelet retention rate in a column of collagen-coated beads is useful for the assessment of efficacy of antiplatelet therapy.
Topics: Aged; Aspirin; Blood Platelets; Cell Separation; Clopidogrel; Collagen; Coronary Artery Disease; Female; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2009 |
Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Animals; Aspirin; Cell Proliferation; Clopidogrel; Collagen; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Fibrin; Hyperplasia; Inflammation Mediators; Metals; P-Selectin; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prosthesis Design; Stents; Swine; Ticlopidine; Time Factors; Tunica Intima | 2008 |
[The 6 top-selling prescription drugs--an interactive evidence-based CME module for GPs on pharmacotherapy].
Topics: Clopidogrel; Drug Therapy; Education, Medical, Continuing; Germany; Humans; Physicians, Family; Platelet Aggregation Inhibitors; Prescription Drugs; Ticlopidine | 2008 |
Calcium-channel blockers reduce the antiplatelet effect of clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Dihydropyridines; Drug Interactions; Female; Flow Cytometry; Humans; Logistic Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Reference Values; Risk Assessment; Sensitivity and Specificity; Statistics, Nonparametric; Ticlopidine; Treatment Outcome | 2008 |
Clopidogrel and calcium-channel antagonists: another drug-drug interaction for the ever-wary clinician?
Topics: Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Drug Interactions; Female; Humans; Male; Platelet Aggregation; Prognosis; Risk Assessment; Ticlopidine; Treatment Outcome | 2008 |
Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis.
Topics: Acute Coronary Syndrome; Age Distribution; Aged; Analysis of Variance; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Artery Bypass; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Incidence; Length of Stay; Logistic Models; Male; Middle Aged; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Predictive Value of Tests; Probability; Reference Values; Reoperation; Retrospective Studies; Risk Assessment; Sex Distribution; Statistics, Nonparametric; Survival Rate; Ticlopidine | 2008 |
Acute reversal of clopidogrel-related platelet inhibition using methyl prednisolone in a patient with intracranial hemorrhage.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Clopidogrel; Female; Humans; Intracranial Hemorrhages; Methylprednisolone; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2008 |
[Perioperative discontinuation of antiplatelet therapy of patients with coronary stents. Reevaluating the risks].
Topics: Algorithms; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Decision Trees; Drug-Eluting Stents; Hemorrhage; Humans; Intraoperative Complications; Long-Term Care; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Risk Factors; Substance Withdrawal Syndrome; Ticlopidine | 2009 |
A paradigm shift in anti-platelet therapy?
Topics: Clopidogrel; Dose-Response Relationship, Drug; Drug Monitoring; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2008 |
Impact of P2Y(12) inhibitory effects induced by clopidogrel on platelet procoagulant activity in type 2 diabetes mellitus patients.
Topics: Blood Coagulation Factors; Clopidogrel; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2009 |
Colonic carcinoma unmasked by dual antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Colonic Neoplasms; Female; Gastrointestinal Hemorrhage; Humans; Incidental Findings; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Clopidogrel under scrutiny.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Research Design; Risk Assessment; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: results from the CADILLAC trial.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Europe; Female; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; United States | 2008 |
ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Platelet Aggregation Inhibitors; Risk Factors; Societies, Medical; Ticlopidine; United States | 2008 |
Measurement of antiplatelet inhibition during neurointerventional procedures: the effect of antithrombotic duration and loading dose.
Topics: Aspirin; Blood Platelets; Brain Diseases; Clopidogrel; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Time Factors | 2010 |
Quantifying low levels of polymorphic impurity in clopidogrel bisulphate by vibrational spectroscopy and chemometrics.
Topics: Clopidogrel; Multivariate Analysis; Polymorphism, Genetic; Powders; Reproducibility of Results; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spectrum Analysis, Raman; Technology, Pharmaceutical; Ticlopidine; Vibration; X-Ray Diffraction | 2009 |
Point-of-care whole blood impedance aggregometry versus classical light transmission aggregometry for detecting aspirin and clopidogrel: the results of a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; ROC Curve; Ticlopidine | 2008 |
[Registration of new clopidogrel preparations--an attack on patent protection?].
Topics: Clopidogrel; Drug and Narcotic Control; Germany; Humans; Patents as Topic; Platelet Aggregation Inhibitors; Therapeutic Equivalency; Ticlopidine | 2008 |
A validated enantiospecific method for determination and purity assay of clopridogrel.
Topics: beta-Cyclodextrins; Biological Assay; Calibration; Chromatography, High Pressure Liquid; Clopidogrel; Computational Biology; Drug Contamination; Guidelines as Topic; Hydrogen-Ion Concentration; Models, Molecular; Molecular Structure; Platelet Aggregation Inhibitors; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Tablets; Technology, Pharmaceutical; Thermodynamics; Ticlopidine | 2009 |
Anti-atherosclerotic effect of atorvastatin and clopidogrel alone and in combination in rats.
Topics: Animals; Atherosclerosis; Atorvastatin; Clopidogrel; Diet, Atherogenic; Drug Interactions; Female; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Wistar; Ticlopidine | 2008 |
Modulation of clopidogrel pharmacodynamic response.
Topics: Anticholesteremic Agents; Area Under Curve; Atorvastatin; Clopidogrel; Drug Interactions; Heptanoic Acids; Humans; Metabolic Clearance Rate; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyrroles; Thiophenes; Ticlopidine | 2008 |
Platelet hyperreactivity and dual antiplatelet therapy: can biases be avoided?
Topics: Bias; Biomedical Research; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
PRoFESS.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Clopidogrel; Dipyridamole; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Telmisartan; Ticlopidine; Treatment Outcome | 2009 |
Antiplatelets for stroke prevention: implications of the PRoFESS trial.
Topics: Aspirin; Cerebral Hemorrhage; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2009 |
Increased morning ADP-dependent platelet aggregation persists despite dual antiplatelet therapy in patients with first ST-segment elevation myocardial infarction: Preliminary report.
Topics: Abciximab; Aged; Antibodies, Monoclonal; Anticoagulants; Circadian Rhythm; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Heparin; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Treatment Outcome | 2008 |
Impact of clopidogrel resistance on thrombotic events after percutaneous coronary intervention with drug-eluting stent.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Mechanism-based inhibition of human cytochrome P450 2B6 by ticlopidine, clopidogrel, and the thiolactone metabolite of prasugrel.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2B6; Dose-Response Relationship, Drug; Humans; Lactones; Microsomes, Liver; Oxidoreductases, N-Demethylating; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
ADP-induced platelet aggregation in acute ischemic stroke patients on aspirin therapy.
Topics: Acute Disease; Adenosine Diphosphate; Aged; Aspirin; Brain Ischemia; Clopidogrel; Drug Synergism; Drug Therapy, Combination; Endpoint Determination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2008 |
The pursuit of clinically relevant measures of platelet function after antiplatelet drug therapy.
Topics: Blood Platelets; Clopidogrel; Coronary Artery Disease; Diabetes Complications; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Risk Factors; Thiophenes; Ticlopidine; Treatment Failure | 2008 |
Gemcitabine-induced acute coronary syndrome: a case report.
Topics: Antimetabolites, Antineoplastic; Aspirin; Bundle-Branch Block; Clopidogrel; Coronary Artery Disease; Coronary Vasospasm; Deoxycytidine; Electrocardiography; Fatal Outcome; Female; Gemcitabine; Humans; Leiomyosarcoma; Lung Neoplasms; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2009 |
Clopidogrel use and bleeding after coronary artery bypass graft surgery.
Topics: Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine | 2008 |
Impact of "nuisance" bleeding on clopidogrel compliance in patients undergoing intracoronary drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Contusions; Coronary Angiography; Coronary Artery Disease; Drug-Eluting Stents; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Observation; Patient Compliance; Platelet Aggregation Inhibitors; Severity of Illness Index; Ticlopidine | 2008 |
Long-term outcomes in patients undergoing coronary stenting on dual oral antiplatelet treatment requiring oral anticoagulant therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Disease-Free Survival; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; International Normalized Ratio; Male; Middle Aged; Mortality; Myocardial Infarction; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Stroke; Ticlopidine | 2008 |
The effects of clopidogrel on elderly traumatic brain injured patients.
Topics: Aged; Aspirin; Brain Damage, Chronic; Brain Injuries; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Disability Evaluation; Female; Glasgow Coma Scale; Humans; Length of Stay; Male; Platelet Aggregation Inhibitors; Prognosis; Registries; Retrospective Studies; Ticlopidine; Warfarin | 2008 |
Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Blood Platelets; Clopidogrel; Drug Interactions; Esomeprazole; Female; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2009 |
Separation and determination of clopidogrel and its impurities by capillary electrophoresis.
Topics: Buffers; Clopidogrel; Cyclodextrins; Drug Contamination; Electricity; Electrophoresis, Capillary; Ethylamines; Hydrogen-Ion Concentration; Molecular Structure; Platelet Aggregation Inhibitors; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Software; Stereoisomerism; Temperature; Ticlopidine | 2009 |
Use of aspirin versus clopidogrel plus aspirin after coronary artery bypass graft surgery.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Survivors; Ticlopidine | 2009 |
A comparison between the Plateletworks-assay and light transmittance aggregometry for monitoring the inhibitory effects of clopidogrel.
Topics: Blood Platelets; Clopidogrel; Drug Monitoring; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Ticlopidine | 2010 |
[Management of a high risk of thrombosis patient with drug-eluting stents undergoing a complete gastrectomy].
Topics: Aged; Clopidogrel; Drug-Eluting Stents; Gastrectomy; Humans; Male; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Stomach Neoplasms; Thrombosis; Ticlopidine | 2009 |
Efficacy and safety of optimized antithrombotic therapy with aspirin, clopidogrel and enoxaparin in patients with non-ST segment elevation acute coronary syndromes in clinical practice.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Drug Evaluation; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Enoxaparin; Female; Fibrinolytic Agents; Hemorrhage; Heparin; Hospital Mortality; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Ticlopidine; Treatment Outcome | 2009 |
Factors associated with bleeding in elderly hospitalized patients treated with enoxaparin sodium : a prospective, open-label, observational study.
Topics: Aged; Aged, 80 and over; Anticoagulants; Body Weight; Clopidogrel; Creatinine; Dose-Response Relationship, Drug; Enoxaparin; Factor Xa Inhibitors; Female; Hemorrhage; Humans; Inpatients; Length of Stay; Logistic Models; Male; Middle Aged; Odds Ratio; Prospective Studies; Risk Factors; Sex Factors; Ticlopidine; Treatment Outcome; Warfarin | 2009 |
Efficacy and safety of prasugrel compared with clopidogrel in patients with acute coronary syndromes: results of TRITON-TIMI 38 trials.
Topics: Acute Coronary Syndrome; Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Clinical Trials, Phase III as Topic; Clopidogrel; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2009 |
A cost-utility analysis of clopidogrel in patients with ST elevation acute coronary syndromes in the UK.
Topics: Aspirin; Clopidogrel; Cost-Benefit Analysis; Drug Costs; Follow-Up Studies; Humans; Markov Chains; Middle Aged; Models, Econometric; Myocardial Infarction; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Survival Analysis; Ticlopidine; United Kingdom | 2010 |
Genetic determinants of response to clopidogrel and cardiovascular events.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Combined Modality Therapy; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Female; Follow-Up Studies; Genotype; Humans; Integrin beta3; Male; Middle Aged; Mortality; Mutation; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Registries; Stroke; Ticlopidine | 2009 |
Cytochrome p-450 polymorphisms and response to clopidogrel.
Topics: Acute Coronary Syndrome; Adult; Angioplasty, Balloon, Coronary; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Combined Modality Therapy; Cytochrome P-450 CYP2C19; Female; Genotype; Heterozygote; Humans; Male; Mutation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Randomized Controlled Trials as Topic; Stents; Thrombosis; Ticlopidine | 2009 |
Clopidogrel in acute coronary syndrome: to genotype or not?
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Death caused by simultaneous subacute stent thrombosis of sirolimus-eluting stents in left anterior descending artery and left circumflex artery.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Occlusion; Coronary Stenosis; Coronary Thrombosis; Drug-Eluting Stents; Electrocardiography; Fatal Outcome; Humans; Immunosuppressive Agents; Male; Middle Aged; Platelet Aggregation Inhibitors; Sirolimus; Tetrazoles; Ticlopidine; Ventricular Fibrillation | 2010 |
Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, clopidogrel, and ticlopidine.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Oxidoreductases, N-Demethylating; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticlopidine | 2008 |
Relation of platelet aggregation and fibrinogen levels to advancing age in aspirin- and thienopyridine-treated patients.
Topics: Aged; Aging; Aspirin; Clopidogrel; Cohort Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fibrinogen; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2008 |
Clopidogrel induces an acute hemostatic deficit and increases intra abdominal bleeding in rabbits.
Topics: Abdomen; Animals; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Flow Cytometry; Hemorrhage; Hemostasis; In Vitro Techniques; Microfilament Proteins; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Rabbits; Ticlopidine | 2009 |
Ask the doctor. I need to catheterize myself because of bladder problems. In April 2007, I had five stents put in my heart and started taking Plavix. Since then, I sometimes see a light tinge of blood in the catheter bag, though lately the blood flow has
Topics: Aged, 80 and over; Clopidogrel; Contraindications; Humans; Platelet Aggregation Inhibitors; Stents; Thoracic Surgery; Ticlopidine; Urinary Catheterization | 2008 |
The treatment of clopidogrel resistance: triple antiplatelet therapy and future directions.
Topics: Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Another view on prasugrel.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Animals; Aspirin; Blood Platelets; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Drug Administration Schedule; Drug Resistance; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Research Design; Risk Assessment; Stents; Thiophenes; Ticlopidine; Treatment Outcome | 2009 |
Improving outcomes with antiplatelet therapies in percutaneous coronary intervention and stenting.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug-Eluting Stents; Hemorrhage; Humans; Patient Selection; Platelet Aggregation Inhibitors; Platelet Function Tests; Practice Guidelines as Topic; Prosthesis Design; Risk Assessment; Stents; Thrombelastography; Ticlopidine; Treatment Outcome | 2009 |
Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; Bleeding Time; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemorrhage; Hemostasis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes; Thrombosis; Ticlopidine | 2009 |
Bleeding risks with combination of oral anticoagulation plus antiplatelet therapy: is clopidogrel any safer than aspirin when combined with warfarin?
Topics: Administration, Oral; Anticoagulants; Aspirin; Blood Coagulation; Clopidogrel; Coumarins; Dipyridamole; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Hemorrhage; Hospitalization; Humans; Platelet Aggregation Inhibitors; Registries; Risk Assessment; Risk Factors; Ticlopidine; Warfarin | 2008 |
Predicting thrombotic events: creating a complex approach for a complex condition.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine | 2008 |
Effect of oral antiplatelet agents on major bleeding in users of coumarins.
Topics: Acenocoumarol; Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Coagulation; Case-Control Studies; Clopidogrel; Coumarins; Dipyridamole; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hemorrhage; Hospitalization; Humans; Logistic Models; Male; Medical Records Systems, Computerized; Middle Aged; Netherlands; Odds Ratio; Phenprocoumon; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Vitamin K | 2008 |
Ask the doctor. In October 2007, I had three Cypher stents placed in my left anterior descending artery. My doctor told me to take Plavix and aspirin indefinitely. Now I need to have a hernia repaired. My surgeon refuses to operate while I'm taking Plavix
Topics: Aspirin; Clopidogrel; Contraindications; Platelet Aggregation Inhibitors; Stents; Thoracic Surgery; Thrombophilia; Ticlopidine | 2008 |
[Proton pump inhibition: more than only reflux therapy].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Asthma; Chest Pain; Clopidogrel; Comorbidity; Controlled Clinical Trials as Topic; Coronary Disease; Diagnosis, Differential; Drug Therapy, Combination; Gastroesophageal Reflux; Humans; Omeprazole; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Rabeprazole; Secondary Prevention; Ticlopidine; Time Factors | 2008 |
The effect of antiplatelet drugs clopidogrel and aspirin is less immediately after stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Antiplatyhelmintic Agents; Aspirin; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Female; Heparin; Humans; In Vitro Techniques; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Function Tests; Stents; Ticlopidine; Time Factors; von Willebrand Factor | 2009 |
Utilization of evidence-based therapy for the secondary prevention of acute coronary syndromes in Australian practice.
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Evidence-Based Medicine; Female; Fibrinolytic Agents; Guideline Adherence; Humans; Male; Middle Aged; New South Wales; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Retrospective Studies; Sex Factors; Ticlopidine | 2008 |
Attenuation of transplant arteriosclerosis with clopidogrel is associated with a reduction of infiltrating dendritic cells and macrophages in murine aortic allografts.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Aorta, Abdominal; Arteriosclerosis; CD40 Ligand; Cell Adhesion Molecules; Chemotaxis; Clopidogrel; Dendritic Cells; Dose-Response Relationship, Drug; Down-Regulation; Histocompatibility Testing; Intercellular Adhesion Molecule-1; Interleukin-6; Lectins, C-Type; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Minor Histocompatibility Antigens; P-Selectin; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Platelet-Derived Growth Factor; Receptors, Cell Surface; RNA, Messenger; Ticlopidine; Transplantation, Homologous | 2009 |
Clopidogrel, genetics, and drug responsiveness.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Mutation; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2009 |
Cost-effectiveness of drug-eluting stents including the economic impact of late stent thrombosis.
Topics: Aged; Clopidogrel; Cost-Benefit Analysis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Thrombosis; Ticlopidine | 2009 |
Oral triple antiplatelet therapy after percutaneous coronary intervention: subject with ongoing arguments?
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stents; Tetrazoles; Ticlopidine; Treatment Outcome | 2010 |
Clopidogrel use in ST-elevation myocardial infarction (STEMI).
Topics: Catheter Ablation; Clopidogrel; Electrocardiography; Emergency Service, Hospital; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2010 |
Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel.
Topics: Chromatography, High Pressure Liquid; Clopidogrel; Cytochrome P-450 Enzyme System; Esters; Fibrinolytic Agents; Humans; Mass Spectrometry; Prodrugs; Sulfenic Acids; Ticlopidine | 2009 |
Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms.
Topics: Adult; Aged; Animals; Cell Line; Clopidogrel; Female; Fibrin; Gene Expression Profiling; Hemodynamics; Humans; Infections; Intensive Care Units; Length of Stay; Leukocytes; Lung; Male; Mice; Mice, Inbred BALB C; Middle Aged; Oligonucleotide Array Sequence Analysis; Platelet Activation; Platelet Aggregation Inhibitors; Pneumonia; Retrospective Studies; Shock, Septic; Ticlopidine | 2009 |
Safety issues of adjunctive clopidogrel in patients discharged after percutaneous coronary intervention with stent placement and requiring oral anticoagulation.
Topics: Administration, Oral; Adult; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Patient Discharge; Stents; Ticlopidine | 2011 |
Clopidogrel-induced fixed drug eruption.
Topics: Aged; Clopidogrel; Drug Eruptions; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
rFVIIa and a new enhanced rFVIIa-analogue, NN1731, reduce bleeding in clopidogrel-treated and in thrombocytopenic rats.
Topics: Animals; Clopidogrel; Factor VII; Factor VIIa; Hemorrhage; Hemostasis; Platelet Count; Rats; Recombinant Proteins; Thrombin; Thrombocytopenia; Ticlopidine | 2009 |
A population-based study of the drug interaction between proton pump inhibitors and clopidogrel.
Topics: Age Distribution; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Case-Control Studies; Clopidogrel; Cohort Studies; Confidence Intervals; Continuity of Patient Care; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Incidence; Male; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Patient Discharge; Patient Readmission; Proton Pump Inhibitors; Recurrence; Risk Assessment; Sex Distribution; Survival Rate; Ticlopidine | 2009 |
Would self-expanding stent occlude middle cerebral artery perforators?
Topics: Adult; Aged; Angioplasty; Aspirin; Clopidogrel; Female; Follow-Up Studies; Humans; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Stroke; Ticlopidine | 2009 |
Propagating knowledge: the value of the single center experience.
Topics: Cardiology; Child; Child Welfare; Clopidogrel; Heart Defects, Congenital; Humans; Pediatrics; Ticlopidine | 2009 |
Impact of preoperative clopidogrel in off pump coronary artery bypass surgery: a propensity score analysis.
Topics: Aged; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Hemostasis, Surgical; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Reoperation; Respiration, Artificial; Ticlopidine | 2009 |
Impact of high loading and maintenance dose of clopidogrel within the first 15 days after percutaneous coronary intervention on patient outcome.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Platelet function analysis: at the edge of meaning.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Humans; Microfilament Proteins; Patient Selection; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reproducibility of Results; Stents; Ticlopidine | 2009 |
Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding.
Topics: Acrylamides; Animals; Clopidogrel; Dinoprostone; Female; Hemorrhage; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Antagonists; Purinergic P2 Receptor Antagonists; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Purinergic P2Y12; Sulfones; Thrombosis; Ticlopidine | 2009 |
Barriers to clopidogrel adherence following placement of drug-eluting stents.
Topics: Adult; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug-Eluting Stents; Exanthema; Female; Humans; Male; Medication Adherence; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Graft Occlusion, Vascular; Homozygote; Humans; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Randomized Controlled Trials as Topic; Risk Factors; Stents; Ticlopidine | 2009 |
Prognosis of patients suffering an acute coronary syndrome while already under chronic clopidogrel therapy.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Disease-Free Survival; Drug Administration Schedule; Drug Therapy, Combination; Female; Hospital Mortality; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Recurrence; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Off-pump replacement of the INCOR implantable axial-flow pump.
Topics: Anticoagulants; Aspirin; Clopidogrel; Equipment Design; Heart-Assist Devices; Humans; Infusion Pumps, Implantable; International Normalized Ratio; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Ventricular Dysfunction, Left; Warfarin | 2009 |
Very late stent thrombosis after discontinuation of clopidogrel therapy.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prosthesis Failure; Ticlopidine; Time Factors; Withholding Treatment | 2009 |
Essential thrombocythemia: a case of acute ST-segment elevation myocardial infarction in a young female.
Topics: Adult; Age Factors; Antisickling Agents; Aspirin; Clopidogrel; Coronary Angiography; Female; Fibrinolytic Agents; Heparin; Humans; Hydroxyurea; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombocythemia, Essential; Ticlopidine; Tirofiban; Tissue Plasminogen Activator; Tyrosine | 2009 |
Drug-coated coronary stents offer life-saving benefits. A 74-year-old Ohio judge is still presiding in court three years after receiving the implants to reopen a blocked artery.
Topics: Aged; Aspirin; Clopidogrel; Contraindications; Coronary Disease; Drug-Eluting Stents; Humans; Male; Ohio; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
PPI interactions with clopidogrel revisited.
Topics: Aryl Hydrocarbon Hydroxylases; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Antagonism; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine | 2009 |
Post-treatment platelet reactivity predicts long-term adverse events better than the response to clopidogrel in patients with non-ST-segment elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Artery Bypass; Electrocardiography; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Predictive Value of Tests; Prognosis; Ticlopidine; Treatment Outcome | 2009 |
Knowledge of coronary stents, thrombosis and dual antiplatelet therapy among Spanish dentists.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Coronary Vessels; Cross-Sectional Studies; Dentists; Health Knowledge, Attitudes, Practice; Humans; Platelet Aggregation Inhibitors; Spain; Stents; Surveys and Questionnaires; Ticlopidine | 2009 |
Antiplatelet effect of clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions--limited inhibition of the P2Y12 receptor.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticlopidine; Treatment Outcome | 2009 |
Optimal pretreatment timing for high load dosing (600 mg) of clopidogrel before planned percutaneous coronary intervention for maximal antiplatelet effectiveness.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2010 |
Transient ischemic attack associated with stenosis of accessory middle cerebral artery: a case report.
Topics: Aphasia; Aspirin; Cerebral Angiography; Clopidogrel; Constriction, Pathologic; Humans; Hypertension; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Magnetic Resonance Angiography; Male; Middle Aged; Middle Cerebral Artery; Paresis; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Facts and controversies of aspirin and clopidogrel therapy.
Topics: Acute Coronary Syndrome; Aspirin; Atherosclerosis; Blood Platelets; Brain Ischemia; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticlopidine | 2009 |
Ischaemia versus bleeding: the art of clinical decision-making.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Decision Making; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2009 |
Evaluation of the platelet count drop method for assessment of platelet function in comparison with "gold standard" light transmission aggregometry.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Reproducibility of Results; Ticlopidine | 2009 |
Investigation of an interaction between statins and clopidogrel after percutaneous coronary intervention: a cohort study.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP3A; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation Inhibitors; Proportional Hazards Models; Ticlopidine | 2009 |
[Bleeding or stent thrombosis in combination with drug-eluting stents].
Topics: Aneurysm, False; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Drug-Eluting Stents; Fatal Outcome; Groin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Factors; Thrombosis; Ticlopidine | 2009 |
Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Cohort Studies; Drug Interactions; Female; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk; Secondary Prevention; Ticlopidine; Treatment Outcome | 2009 |
Focus on adjunctive pharmacotherapy to improve outcomes of percutaneous coronary intervention.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Chemotherapy, Adjuvant; Clopidogrel; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Therapy; Electrocardiography; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Treatment Outcome | 2009 |
Successful clopidogrel desensitization after drug-eluting stent implantation.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Desensitization, Immunologic; Drug-Eluting Stents; Electrocardiography; Exanthema; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Platelet Aggregation Inhibitors; Pruritus; Ticlopidine | 2009 |
Long-term clopidogrel administration following severe coronary injury reduces proliferation and inflammation via inhibition of nuclear factor-kappaB and activator protein 1 activation in pigs.
Topics: Animals; Aspirin; Clopidogrel; Coronary Restenosis; Disease Models, Animal; Drug Therapy, Combination; NF-kappa B; Platelet Aggregation Inhibitors; Statistics as Topic; Sus scrofa; Ticlopidine; Time Factors; Transcription Factor AP-1 | 2009 |
Athero-embolic isolated splenic infarction following left cardiac catheterization.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aortic Aneurysm, Abdominal; Aspirin; Atherosclerosis; Cardiac Catheterization; Clopidogrel; Coronary Stenosis; Embolism, Cholesterol; Heparin; Humans; Infarction; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Spleen; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Warfarin | 2009 |
Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Electric Impedance; Electrodes; Female; Humans; Kaplan-Meier Estimate; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Prospective Studies; Thrombosis; Ticlopidine | 2009 |
Point-of-care platelet function analysis ready for prime time?
Topics: Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Thrombosis; Ticlopidine | 2009 |
Multiple mechanisms affect the clopidogrel response.
Topics: Biomarkers; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Diabetes Complications; Fibrinogen; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2009 |
Variability of response to antiplatelet therapy: what should we do next?
Topics: Aspirin; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Dose-Response Relationship, Drug; Drug Design; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2009 |
Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2009 |
Spectrophotometric and spectrodensitometric determination of Clopidogrel Bisulfate with kinetic study of its alkaline degradation.
Topics: Alkalies; Calibration; Clopidogrel; Densitometry; Kinetics; Methods; Pharmaceutical Preparations; Spectrophotometry; Ticlopidine | 2009 |
Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs.
Topics: Animals; Area Under Curve; Clopidogrel; Cytochrome P-450 Enzyme System; Dogs; Hydrolysis; Male; Molecular Structure; Oxidation-Reduction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Rats; Rats, Sprague-Dawley; Thiophenes; Ticlopidine | 2009 |
Platelets play important roles in the late phase of the immediate hypersensitivity reaction.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Hypersensitivity, Immediate; Immunoglobulin E; Leukocytes; Mice; Ovalbumin; P-Selectin; Platelet Transfusion; Skin; Ticlopidine | 2009 |
The ischaemia/bleeding balance in PCI.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Hemorrhage; Humans; Lactones; Platelet Aggregation Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Receptors, Thrombin; Severity of Illness Index; Thrombin; Ticlopidine | 2009 |
Assessment of platelet inhibition secondary to clopidogrel and aspirin therapy in preoperative acute surgical patients measured by Thrombelastography Platelet Mapping.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Thrombelastography; Ticlopidine | 2009 |
Factors associated with aspirin resistance in patients premedicated with aspirin and clopidogrel for endovascular neurosurgery.
Topics: Aged; Aneurysm; Aspirin; Cerebral Revascularization; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2009 |
Very late stent thrombosis after discontinuation of clopidogrel therapy.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prosthesis Failure; Ticlopidine; Time Factors; Withholding Treatment | 2009 |
Summaries for patients. What aspirin dose is safest and most effective for preventing heart disease?
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Primary Prevention; Risk Factors; Thrombosis; Ticlopidine | 2009 |
Summaries for patients. Aspirin for the prevention of cardiovascular disease: U.S. Preventive Services Task Force recommendation statement.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Primary Prevention; Risk Factors; Thrombosis; Ticlopidine | 2009 |
Aspirin to prevent cardiovascular disease: the association of aspirin dose and clopidogrel with thrombosis and bleeding.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Observation; Platelet Aggregation Inhibitors; Primary Prevention; Prospective Studies; Randomized Controlled Trials as Topic; Risk Factors; Thrombosis; Ticlopidine | 2009 |
Anticoagulant and antiplatelet usage associates with mortality among hemodialysis patients.
Topics: Aged; Anticoagulants; Clopidogrel; Cohort Studies; Confidence Intervals; Female; Humans; International Normalized Ratio; Kidney Failure, Chronic; Longitudinal Studies; Male; Platelet Aggregation Inhibitors; Proportional Hazards Models; Racial Groups; Renal Dialysis; Retrospective Studies; Risk Assessment; Ticlopidine; Warfarin | 2009 |
Does the combination of warfarin and aspirin have a place in secondary stroke prevention? Yes.
Topics: Anticoagulants; Aspirin; Clopidogrel; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk; Stroke; Ticlopidine; Warfarin | 2009 |
Prolonged dual antiplatelet therapy improves clinical outcomes in high-risk patients implanted with sirolimus-eluting stents.
Topics: Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Humans; Immunosuppressive Agents; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Sirolimus; Ticlopidine; Treatment Outcome | 2009 |
PCI, stents, clopidogrel and non-cardiac surgery.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stents; Surgical Procedures, Operative; Ticlopidine | 2009 |
Clopidogrel pretreatment before primary percutaneous coronary stenting in patients with acute ST-segment elevation myocardial infarction: comparison of high loading dose (600 mg) versus low loading dose (300 mg).
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Clopidogrel for preventing cardiovascular events.
Topics: Aspirin; Clopidogrel; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Evidence-Based Medicine; Female; Humans; Hypertension; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Stroke; Ticlopidine | 2009 |
Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Proliferation; Cells, Cultured; Clopidogrel; Disease Models, Animal; Endothelium, Vascular; Female; Fibrosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Aggregation Inhibitors; Sinus of Valsalva; Spleen; Stem Cells; T-Lymphocytes, Regulatory; Ticlopidine | 2009 |
Temporal trends and patterns of early clopidogrel use across the spectrum of acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Cardiac Catheterization; Clopidogrel; Drug Utilization; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
The association between socioeconomic status of high-risk patients with coronary heart disease and the treatment rates of evidence-based medicine for coronary heart disease secondary prevention in China: Results from the Bridging the Gap on CHD Secondary
Topics: Aged; China; Clopidogrel; Coronary Disease; Cross-Sectional Studies; Evidence-Based Medicine; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Morbidity; Platelet Aggregation Inhibitors; Prognosis; Risk Assessment; Secondary Prevention; Socioeconomic Factors; Survival Rate; Ticlopidine | 2009 |
Novel antiplatelet strategies in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clinical Trials, Phase III as Topic; Clopidogrel; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2009 |
The drug-drug interaction between proton pump inhibitors and clopidogrel.
Topics: Clopidogrel; Drug Incompatibility; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Assessment; Ticlopidine | 2009 |
Contemporary issues on clopidogrel therapy: a critical appraisal.
Topics: Clopidogrel; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Platelet activity and outcome after intracerebral hemorrhage.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cerebral Hemorrhage; Clopidogrel; Female; Glasgow Coma Scale; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Severity of Illness Index; Ticlopidine; Treatment Outcome | 2009 |
Bleeding risk with AZD6140, a reversible P2Y12 receptor antagonist, vs. clopidogrel in patients undergoing coronary artery bypass grafting in the DISPERSE2 trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome | 2009 |
Plateletworks: a screening assay for clopidogrel therapy monitoring in healthy cats.
Topics: Animals; Blood Platelets; Cardiomyopathies; Cat Diseases; Cats; Clopidogrel; Female; Male; Monitoring, Physiologic; Orchiectomy; Ovariectomy; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Thromboembolism; Ticlopidine | 2009 |
Very late drug-eluting stent thrombosis after nonsteroidal anti-inflammatory drug treatment despite dual antiplatelet therapy.
Topics: Adult; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Cyclooxygenase Inhibitors; Diabetic Angiopathies; Diclofenac; Drug Interactions; Drug-Eluting Stents; Endothelium, Vascular; Humans; Intervertebral Disc Displacement; Male; Meloxicam; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Thiazines; Thiazoles; Ticlopidine; Time Factors | 2009 |
Clopidogrel and pregnancy: a situation pregnant with danger?
Topics: Adult; Blood Loss, Surgical; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Cardiovascular; Ticlopidine | 2009 |
Does the Holy Grail escape us again?
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2009 |
Ticlopidine as a safe alternative for clopidogrel-associated arthritis.
Topics: Arthritis; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Treatment of multilesion coronary artery disease with simultaneous drug-eluting and bare-metal stent implantation: clinical follow up and angiographic mid-term results.
Topics: Abciximab; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Coronary Vessels; Databases as Topic; Drug-Eluting Stents; Drug-Related Side Effects and Adverse Reactions; Female; Heparin; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Combined, superselective pharmacological management of large coronary thrombus burden.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Coronary Thrombosis; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Registries; Stents; Ticlopidine; Urokinase-Type Plasminogen Activator | 2009 |
Spontaneous coronary artery dissection and severe hypothyroidism.
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Eptifibatide; Fatal Outcome; Female; Humans; Hypothyroidism; Neck Pain; Peptides; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Bridging with GP IIb/IIIa inhibitors after abdominal surgery in a patient presenting with late stent thrombosis of a drug-eluting stent and who cannot receive oral antiplatelet treatment.
Topics: Administration, Oral; Aged; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Humans; Male; Perioperative Care; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoprotein IIb; Ticlopidine; Time Factors | 2009 |
A survey of the peri-operative management of urological patients on clopidogrel.
Topics: Anesthesia; Clopidogrel; Elective Surgical Procedures; Humans; Intraoperative Care; Medical Staff, Hospital; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Professional Practice; Risk Factors; Surveys and Questionnaires; Thrombosis; Ticlopidine; Urologic Diseases; Urology | 2009 |
Cytochrome P450 2C19 polymorphism and clopidogrel after MI.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Heterozygote; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prodrugs; Prognosis; Research Design; Ticlopidine; Treatment Outcome | 2009 |
Cytochrome P450 2C19 polymorphism and clopidogrel after MI.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Follow-Up Studies; Heterozygote; Humans; Medication Adherence; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prognosis; Ticlopidine; Treatment Outcome | 2009 |
Cytochrome P450 2C19 polymorphism and clopidogrel after MI.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Liver; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Safety; Ticlopidine; Treatment Outcome | 2009 |
Predicting drug interaction of clopidogrel on microbial metabolism of diclofenac.
Topics: Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Liquid; Clopidogrel; Diclofenac; Drug Interactions; Fungi; Mass Spectrometry; Ticlopidine; Time Factors | 2010 |
Clopidogrel and proton pump inhibitors: gastric protection at expense of vascular benefit?
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Humans; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Stents; Ticlopidine | 2009 |
Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Male; Middle Aged; Multivariate Analysis; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Stents; Ticlopidine | 2009 |
The P2Y12 receptor: no active metabolite, no party.
Topics: Aryl Hydrocarbon Hydroxylases; Biological Availability; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Resistance; Genetic Variation; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Failure | 2009 |
Dual antiplatelet drug resistance is a risk factor for cardiovascular events after percutaneous coronary intervention.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2009 |
Early, accurate, non-invasive predictors of left main or 3-vessel disease in patients with non-ST-segment elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Electrocardiography; Female; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prognosis; Retrospective Studies; Sensitivity and Specificity; Ticlopidine; Troponin T | 2009 |
Use of a thrombelastograph platelet mapping assay for diagnosis of clopidogrel resistance: a case report.
Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Blood Platelets; Cardiac Catheterization; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombelastography; Ticlopidine; Warfarin | 2009 |
Cytochrome p-450 polymorphisms and response to clopidogrel.
Topics: Acute Coronary Syndrome; Adult; Clopidogrel; Cytochrome P-450 Enzyme System; Female; Humans; Male; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Ticlopidine; Treatment Outcome | 2009 |
Acute severe pancytopenia associated with clopidogrel.
Topics: Acute Disease; Aged, 80 and over; Clopidogrel; Female; Humans; Pancytopenia; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Central retinal vein occlusion secondary to clomiphene treatment in a male carrier of factor V Leiden.
Topics: Adult; Clomiphene; Clopidogrel; Eye; Factor V; Fluorescein Angiography; Heterozygote; Humans; Infertility, Male; Male; Mutation; Retinal Vein Occlusion; Ticlopidine; Treatment Outcome | 2009 |
Update on dual antiplatelet therapy for percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Pyridines; Stents; Thrombosis; Ticlopidine | 2009 |
Proton pump inhibitors and clopidogrel - hazardous drug interaction or hazardous interpretation of data?
Topics: Aspirin; Clopidogrel; Cytochrome P-450 Enzyme System; Data Interpretation, Statistical; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Assessment; Ticlopidine | 2009 |
[Do antiplatelet agents (aspirin and other antiplatelets such as clopidogrel) increase the risk of hemorrhagic complications after endoscopic polypectomy or endoscopic sphincterotomy and should these drugs therefore be withdrawn 7-10 days before these pro
Topics: Aspirin; Clopidogrel; Colonic Polyps; Colonoscopy; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Guidelines as Topic; Preoperative Care; Risk Factors; Sphincterotomy, Endoscopic; Ticlopidine; Time Factors | 2009 |
The effect of intended duration of clopidogrel use on early and late mortality and major adverse cardiac events in patients with drug-eluting stents.
Topics: Aged; Clopidogrel; Coronary Stenosis; Drug Administration Schedule; Drug-Eluting Stents; Female; Follow-Up Studies; Graft Occlusion, Vascular; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Revascularization; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome; Victoria | 2009 |
Antiplatelet therapy: Personalized medicine for clopidogrel resistance?
Topics: Biomarkers; Clopidogrel; Drug Resistance; Humans; Patient Selection; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Risk Assessment; Ticlopidine; Treatment Failure | 2009 |
[Late thrombosis in paclitaxel-eluting stent after discontinuation of clopidogrel medication - a case report with 2-year follow-up].
Topics: Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Thrombosis; Drug Administration Schedule; Drug-Eluting Stents; Follow-Up Studies; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Incidence of stent thrombosis in patients with drug eluting stents and short-term dual antiplatelet therapy.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Artery Disease; Databases as Topic; Drug Administration Schedule; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Incidence; Kaplan-Meier Estimate; Male; Medication Adherence; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Reduced platelet activity is more common than reported anti-platelet medication use in patients with intracerebral hemorrhage.
Topics: Aged; Aspirin; Blood Platelets; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Ticlopidine; Warfarin | 2009 |
[Taking metabolic pathways into consideration. Approved drug against problematic interactions ].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Gastroesophageal Reflux; Humans; Pantoprazole; Ticlopidine | 2009 |
Dual antiplatelet therapy after percutaneous coronary intervention with stent implantation in patients taking chronic oral anticoagulation.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Incidence and prognostic significance of thrombocytopenia developed during acute coronary syndrome in contemporary clinical practice.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angina, Unstable; Anticoagulants; Aspirin; Clopidogrel; Female; Hemorrhage; Heparin; Humans; Incidence; Inpatients; Logistic Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Platelet Count; Prognosis; Registries; Risk Factors; Severity of Illness Index; Thrombocytopenia; Ticlopidine | 2009 |
Clopidogrel and the concept of high-risk pharmacokinetics.
Topics: Aryl Hydrocarbon Hydroxylases; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Variation; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2009 |
Aspirin plus clopidogrel and risk of infection after coronary artery bypass surgery.
Topics: Aged; Aspirin; Bacteremia; Blood Transfusion; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Surgical Wound Infection; Ticlopidine; Transfusion Reaction | 2009 |
Effective platelet inhibition by aspirin and clopidogrel: where are we now?
Topics: Aspirin; Clopidogrel; Coronary Disease; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Ticlopidine; Treatment Failure | 2009 |
Antithrombotic therapy for the prevention of reinfarction after reperfusion therapy: the price of success.
Topics: China; Clinical Trials as Topic; Clopidogrel; Electrocardiography; Fibrinolytic Agents; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Reperfusion; Secondary Prevention; Thrombolytic Therapy; Ticlopidine | 2009 |
Influence of platelet reactivity and response to clopidogrel on myocardial damage following percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Female; Heart; Humans; Male; Middle Aged; Myocardium; Platelet Aggregation; Prospective Studies; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2009 |
[Rather common, but not indefensible].
Topics: Clopidogrel; Cytochrome P-450 Enzyme System; Genotype; Humans; Platelet Aggregation Inhibitors; Prodrugs; Ticlopidine | 2009 |
Combined carotid stenting and urgent coronary artery surgery in unstable angina patients with severe carotid stenosis.
Topics: Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon; Anticoagulants; Aspirin; Carotid Stenosis; Clopidogrel; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Coronary Artery Disease; Drug Administration Schedule; Female; Heparin; Humans; Male; Platelet Aggregation Inhibitors; Risk Assessment; Severity of Illness Index; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Predictors of heightened platelet reactivity despite dual-antiplatelet therapy in patients undergoing percutaneous coronary intervention.
Topics: Aged; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Disease; Drug Interactions; Drug-Eluting Stents; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Sirolimus; Ticlopidine; Treatment Outcome | 2009 |
[Introduction to the topic: drug eluting stents. An underestimated problem in surgery].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Drug-Eluting Stents; Hemorrhage; Humans; Intraoperative Complications; Long-Term Care; Platelet Aggregation Inhibitors; Risk Factors; Substance Withdrawal Syndrome; Ticlopidine | 2009 |
[Patients with coronary artery stents: when and how should operations be carried out?].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cooperative Behavior; Coronary Restenosis; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Interdisciplinary Communication; Intraoperative Complications; Long-Term Care; Patient Education as Topic; Platelet Aggregation Inhibitors; Reoperation; Risk Factors; Substance Withdrawal Syndrome; Ticlopidine | 2009 |
[Drug-eluting stents: implications for surgery patients].
Topics: Algorithms; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cooperative Behavior; Coronary Restenosis; Decision Trees; Drug-Eluting Stents; Evidence-Based Medicine; Guideline Adherence; Hemorrhage; Humans; Interdisciplinary Communication; Intraoperative Complications; Long-Term Care; Patient Care Team; Platelet Aggregation Inhibitors; Risk Assessment; Substance Withdrawal Syndrome; Ticlopidine | 2009 |
Effect of exercise on platelet activation during aspirin or clopidogrel intake in healthy men.
Topics: Adolescent; Adult; Aspirin; Clopidogrel; Exercise; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; von Willebrand Factor; Young Adult | 2009 |
The ACTIVE pursuit of stroke prevention in patients with atrial fibrillation.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Vitamin K | 2009 |
Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Drug Monitoring; Female; Flow Cytometry; Humans; Male; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Tissue Fixation | 2009 |
Evidence guided antiplatelet treatment: time to move from bench to bedside.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiology; Cardiovascular Diseases; Clopidogrel; Drug Therapy; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
Platelet reactivity on aspirin, clopidogrel and abciximab in patients with acute coronary syndromes and reduced estimated glomerular filtration rate.
Topics: Abciximab; Acute Coronary Syndrome; Aged; Aged, 80 and over; Antibodies, Monoclonal; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
ACTIVE A: balancing the benefits and risks of clopidogrel and aspirin.
Topics: Aged; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Female; Humans; Intracranial Hemorrhages; Male; Platelet Aggregation Inhibitors; Risk; Stroke; Ticlopidine | 2009 |
Levetiracetam-induced platelet dysfunction.
Topics: Aged; Anticonvulsants; Blood Platelet Disorders; Clopidogrel; Humans; Levetiracetam; Magnetic Resonance Imaging; Male; Piracetam; Platelet Aggregation; Platelet Aggregation Inhibitors; Seizures; Ticlopidine | 2009 |
An assessment of cardiopulmonary bypass-induced changes in platelet function using whole blood and classical light transmission aggregometry: the results of a pilot study.
Topics: Aged; Anesthesia; Aspirin; Blood Loss, Surgical; Blood Platelets; Cardiopulmonary Bypass; Clopidogrel; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; ROC Curve; Ticlopidine | 2009 |
Therapeutic strategies after coronary stenting in chronically anticoagulated patients: the MUSICA study.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Chronic Disease; Clopidogrel; Coronary Disease; Disease-Free Survival; Drug Therapy, Combination; Female; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stents; Thromboembolism; Ticlopidine; Treatment Outcome; Warfarin | 2009 |
Headache and visual symptoms in two patients with MRI alterations in posterior cerebral artery territory.
Topics: Acute Disease; Adult; Aged; Anticoagulants; Clopidogrel; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Female; Headache; Hemianopsia; Heparin; Humans; Infarction, Posterior Cerebral Artery; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Migraine Disorders; Nimodipine; Recurrence; Ticlopidine; Vasodilator Agents; Vasospasm, Intracranial; Vision Disorders | 2009 |
Acknowledging a failed strategy.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Disease-Free Survival; Drug Administration Schedule; Drug Therapy, Combination; Hospital Mortality; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Failure; Treatment Outcome | 2009 |
A very late stent thrombosis in a patient with diabetes: a call for lifelong dual anti-platelet therapy.
Topics: Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Thrombosis; Ticlopidine; Time Factors | 2009 |
Clopidogrel. Bleeding and resistance.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Resistance; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Clopidogrel. Increasing concordance.
Topics: Acute Coronary Syndrome; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Clopidogrel. More on proton pump inhibitors.
Topics: Clopidogrel; Drug Combinations; Humans; Myocardial Infarction; Proton Pump Inhibitors; Recurrence; Risk Factors; Ticlopidine | 2009 |
Clopidogrel. Patients with peptic ulcers.
Topics: Aspirin; Clopidogrel; Histamine H2 Antagonists; Humans; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Ticlopidine | 2009 |
Cytochrome P-450 polymorphisms and response to clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Linkage Disequilibrium; Microsomes; Omeprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2009 |
Acute coronary syndromes: don't bypass the clopidogrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhibitors; Preoperative Care; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
[Clopidogrel in the treatment of atrial fibrillation: comparison with warfarin. The results of ACTIVE W trial].
Topics: Aged; Anticoagulants; Atrial Fibrillation; Clopidogrel; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Middle Aged; Platelet Aggregation Inhibitors; Russia; Stroke; Survival Rate; Ticlopidine; Treatment Outcome; Warfarin | 2009 |
Stent thrombosis, clinical events, and influence of prolonged clopidogrel use after placement of drug-eluting stent data from an observational cohort study of drug-eluting versus bare-metal stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Coronary Artery Disease; Drug Administration Schedule; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Korea; Male; Metals; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prosthesis Design; Risk Assessment; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2008 |
Preliminary results of the hydroxyapatite nonpolymer-based sirolimus-eluting stent for the treatment of single de novo coronary lesions a first-in-human analysis of a third-generation drug-eluting stent system.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Durapatite; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Prosthesis Design; Registries; Sirolimus; Stainless Steel; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Interventional | 2008 |
Searching for the ceiling: new reflections on the disposition and metabolism of clopidogrel.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Genotype; Humans; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Thrombosis; Ticlopidine | 2008 |
Lowering the dose of sirolimus, released from a nonpolymeric hydroxyapatite coated coronary stent, reduces signs of delayed healing.
Topics: Angioplasty, Balloon, Coronary; Animals; Aspirin; Cardiovascular Agents; Clopidogrel; Coated Materials, Biocompatible; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Drug-Eluting Stents; Durapatite; Hyperplasia; Lipids; Materials Testing; Models, Animal; Platelet Aggregation Inhibitors; Prosthesis Design; Sirolimus; Stainless Steel; Surface Properties; Sus scrofa; Ticlopidine; Wound Healing | 2009 |
The excel stent: a good DES, but can we really stop clopidogrel after 6 months?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coated Materials, Biocompatible; Coronary Artery Disease; Coronary Restenosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Polymers; Prosthesis Design; Risk Assessment; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Simultaneous hybrid revascularization by carotid stenting and coronary artery bypass grafting: the SHARP study.
Topics: Aged; Angioplasty, Balloon, Coronary; Carotid Arteries; Carotid Artery Diseases; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors; Tomography, X-Ray Computed | 2009 |
1-year results of the hydroxyapatite polymer-free sirolimus-eluting stent for the treatment of single de novo coronary lesions: the VESTASYNC I trial.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Durapatite; Female; Humans; Intensive Care Units; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymers; Prospective Studies; Sirolimus; Ticlopidine; Time Factors; Ultrasonography | 2009 |
A volumetric intravascular ultrasound comparison of early drug-eluting stent thrombosis versus restenosis.
Topics: Analysis of Variance; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors; Ultrasonography, Interventional | 2009 |
Local determinants of thrombus formation following sirolimus-eluting stent implantation assessed by optical coherence tomography.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Immunosuppressive Agents; Japan; Male; Multivariate Analysis; Platelet Aggregation Inhibitors; Prospective Studies; Risk Assessment; Risk Factors; Sirolimus; Ticlopidine; Tomography, Optical Coherence; Ultrasonography, Interventional | 2009 |
Regarding comparison of percutaneous coronary intervention with bare-metal and drug-eluting stents for cardiac allograft vasculopathy: problems with listing patients receiving clopidogrel for re-transplantation.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine; Transplantation, Homologous; Treatment Failure | 2009 |
Effect of long-term clopidogrel treatment on platelet function and inflammation in patients undergoing coronary arterial stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Apyrase; Blood Platelets; Clopidogrel; Female; Flow Cytometry; Humans; Inflammation; Male; Middle Aged; Myocardial Ischemia; P-Selectin; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2009 |
Impact of combining proton pump inhibitors and clopidogrel.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Secondary Prevention; Ticlopidine | 2009 |
External beam radiotherapy for prostate cancer patients on anticoagulation therapy: how significant is the bleeding toxicity?
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Androgen Antagonists; Anticoagulants; Clopidogrel; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Multivariate Analysis; Prostatic Neoplasms; Radiotherapy Dosage; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Rectum; Severity of Illness Index; Ticlopidine; Transurethral Resection of Prostate; Urologic Diseases; Warfarin | 2010 |
Proton pump inhibitors and clopidogrel: a difficult dilemma.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Thrombosis; Ticlopidine | 2009 |
Cytochrome P-450 polymorphisms and response to clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Heterozygote; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2009 |
Coronary artery disease: Platelet activity: an obstacle for successful PCI.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Patient Selection; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Antiplatelet therapy: Clopidogrel plus PPIs-a dangerous combination?
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 2009 |
Combined anti-platelet therapy with aspirin and clopidogrel: risk factor for thrombolysis-related intracerebral hemorrhage in acute ischemic stroke?
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recombinant Proteins; Retrospective Studies; Risk Factors; Severity of Illness Index; Thrombolytic Therapy; Thrombophilia; Ticlopidine; Tissue Plasminogen Activator | 2009 |
Shear-induced global thrombosis test of native blood: pivotal role of ADP allows monitoring of P2Y12 antagonist therapy.
Topics: Adenosine Diphosphate; Adult; Blood Coagulation; Clopidogrel; Female; Humans; Male; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Reference Values; Ticlopidine | 2009 |
Coronary aneurysms after drug-eluting stent implantation: clinical, angiographic, and intravascular ultrasound findings.
Topics: Adult; Aged; Clopidogrel; Confidence Intervals; Coronary Aneurysm; Coronary Angiography; Coronary Restenosis; Coronary Thrombosis; Databases as Topic; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Ultrasonography, Interventional | 2009 |
Aprotinin reduces the antiplatelet effect of clopidogrel.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aprotinin; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Interactions; Drug Therapy, Combination; Female; Hemostatics; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Factors that decrease the effectiveness of clopidogrel.
Topics: Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Monitoring; Genetic Variation; Humans; Nurse's Role; Nursing Assessment; Patient Education as Topic; Platelet Aggregation Inhibitors; Prodrugs; Proton Pump Inhibitors; Ticlopidine | 2009 |
Prevention of stroke in patients with atrial fibrillation.
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; Treatment Outcome; Vitamin K; Warfarin | 2009 |
Prasugrel STEMI subgroup analysis.
Topics: Clopidogrel; Data Interpretation, Statistical; Electrocardiography; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Research Design; Thiophenes; Ticlopidine; Treatment Outcome | 2009 |
Prasugrel STEMI subgroup analysis.
Topics: Clopidogrel; Data Interpretation, Statistical; Drug Administration Schedule; Electrocardiography; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Research Design; Thiophenes; Ticlopidine; Treatment Outcome | 2009 |
Prasugrel STEMI subgroup analysis.
Topics: Aspirin; Clopidogrel; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Research Design; Thiophenes; Ticlopidine | 2009 |
Variability in aggregometry response before and after initiation of clopidogrel therapy.
Topics: Adenosine Diphosphate; Arachidonic Acid; Aspirin; Case-Control Studies; Clopidogrel; Demography; Female; Humans; Male; Middle Aged; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reproducibility of Results; Ticlopidine | 2009 |
Risks of proton-pump inhibitors: what every doctor should know. Comment.
Topics: Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Gastric Acid; Gastric Mucosa; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Secondary Prevention; Ticlopidine | 2009 |
Can we override clopidogrel resistance?
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Biotransformation; Clopidogrel; Combined Modality Therapy; Coronary Restenosis; Drug Resistance; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prasugrel Hydrochloride; Prodrugs; Radiography; Stents; Thiophenes; Ticlopidine | 2009 |
Cost-effectiveness of clopidogrel plus aspirin versus aspirin alone for secondary prevention of cardiovascular events: results from the CHARISMA trial.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Databases, Factual; Drug Therapy, Combination; Female; Health Care Costs; Hospitalization; Humans; Life Expectancy; Male; Middle Aged; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Saskatchewan; Secondary Prevention; Survival Analysis; Ticlopidine; United States | 2009 |
Future of oral antiplatelet therapy: four challenged hypotheses.
Topics: Adenosine; Clinical Trials as Topic; Clopidogrel; Coronary Thrombosis; Cost-Benefit Analysis; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Prognosis; Purinergic P2 Receptor Antagonists; Pyridines; Risk Assessment; Survival Rate; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2009 |
Frequency and outcomes of provisional glycoprotein IIb/IIIa blockade in patients receiving bivalirudin during percutaneous coronary intervention.
Topics: Abciximab; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Embolism; Eptifibatide; Female; Follow-Up Studies; Hirudins; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Registries; Regression Analysis; Retrospective Studies; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Saving lives, money and resources: drug and CABG/PCI use after myocardial infarction in a Swedish record-linkage study.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Atherectomy; Catheter Ablation; Clopidogrel; Coronary Artery Bypass; Diabetes Mellitus; Drug Therapy, Combination; Female; Health Care Costs; Hospital Costs; Humans; Male; Medical Record Linkage; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Proportional Hazards Models; Registries; Risk Factors; Simvastatin; Sweden; Ticlopidine; Treatment Outcome | 2010 |
Pharmacy benefit spending poised to increase for antithrombotic drug therapy -- prasugrel versus clopidogrel.
Topics: Clopidogrel; Commerce; Drug Costs; Humans; Insurance, Pharmaceutical Services; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2009 |
Crushed clopidogrel administered via nasogastric tube has faster and greater absorption than oral whole tablets.
Topics: Adult; Area Under Curve; Biological Availability; Clopidogrel; Confidence Intervals; Female; Humans; Intubation, Gastrointestinal; Male; Odds Ratio; Platelet Aggregation Inhibitors; Tablets; Ticlopidine | 2009 |
The CYP2C19*17 allele is associated with better platelet response to clopidogrel in patients admitted for non-ST acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2009 |
Interaction between clopidogrel and proton pump inhibitors.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Case-Control Studies; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Myocardial Infarction; Odds Ratio; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Secondary Prevention; Ticlopidine | 2009 |
Interaction between clopidogrel and proton pump inhibitors.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Case-Control Studies; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Lansoprazole; Myocardial Infarction; Odds Ratio; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Secondary Prevention; Ticlopidine | 2009 |
Development and validation of a risk scoring model to predict net adverse cardiovascular outcomes after primary percutaneous coronary intervention in patients pretreated with 600 mg clopidogrel: rationale and design of the RISK-PCI study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Female; Humans; Kaplan-Meier Estimate; Logistic Models; Longitudinal Studies; Male; Middle Aged; Models, Statistical; Models, Theoretical; Multivariate Analysis; Platelet Aggregation Inhibitors; Research Design; Risk Assessment; Risk Factors; ROC Curve; Ticlopidine; Treatment Outcome | 2009 |
[Cardiology 2009].
Topics: Aryl Hydrocarbon Hydroxylases; Atrial Fibrillation; Cardiology; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Exercise; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stroke Volume; Ticlopidine | 2009 |
Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent implantation.
Topics: Aspirin; Cellular Senescence; Cilostazol; Clopidogrel; Down-Regulation; Drug-Eluting Stents; Endothelium, Vascular; Everolimus; Humans; Immunosuppressive Agents; Nitric Oxide Synthase Type III; Oxidative Stress; Paclitaxel; Plasminogen Activator Inhibitor 1; Platelet Aggregation Inhibitors; Sirolimus; Sirtuin 1; Sirtuins; Tetrazoles; Ticlopidine; Vasodilator Agents | 2009 |
Characterization of degradation products of amorphous and polymorphic forms of clopidogrel bisulphate under solid state stress conditions.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Clopidogrel; Computer Simulation; Dosage Forms; Drug Stability; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Light; Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Photolysis; Platelet Aggregation Inhibitors; Reproducibility of Results; Technology, Pharmaceutical; Ticlopidine; Time Factors; X-Ray Diffraction | 2010 |
Tailored medical and interventional therapy against recurrent stent thrombosis after drug-eluting stenting.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Thrombosis; Drug-Eluting Stents; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Ticlopidine | 2010 |
Triple versus dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Combined Modality Therapy; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Registries; Retrospective Studies; Tetrazoles; Ticlopidine | 2009 |
ACC/AHA guideline update for the management of ST-segment elevation myocardial infarction.
Topics: Antihypertensive Agents; Aspirin; Catheter Ablation; Clopidogrel; Combined Modality Therapy; Electrocardiography; Exercise Therapy; Humans; Hypolipidemic Agents; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Secondary Prevention; Smoking Cessation; Ticlopidine | 2009 |
Clopidogrel versus low-dose aspirin as risk factors for epistaxis.
Topics: Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Epistaxis; Humans; Hypertension; Myocardial Ischemia; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2009 |
Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan.
Topics: Adenosine Diphosphate; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Female; Humans; Japan; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2; Ticlopidine | 2009 |
[Percutaneous endoscopic gastrostomy. Complications with and without anticoagulation].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Child; Child, Preschool; Clopidogrel; Contraindications; Drug Therapy, Combination; Female; Gastrostomy; Heparin, Low-Molecular-Weight; Humans; Infant; Male; Middle Aged; Multivariate Analysis; Peritonitis; Pilot Projects; Postoperative Complications; Postoperative Hemorrhage; Prognosis; Prospective Studies; Risk Factors; Surgical Wound Infection; Thromboembolism; Ticlopidine | 2010 |
Relevance of metabolic activation pathways: the example of clopidogrel and prasugrel.
Topics: Animals; Biotransformation; Clopidogrel; Cytochrome P-450 Enzyme System; Genetic Variation; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
Do the association of cytochrome P450 interacting drugs, influence clopidogrel efficacity?
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Blood Platelets; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Beneficial effect of clopidogrel in a mouse model of polymicrobial sepsis.
Topics: Animals; Clopidogrel; Mice; Platelet Aggregation Inhibitors; Sepsis; Ticlopidine | 2009 |
Dual antiplatelet therapy for more than 12 months after percutaneous coronary intervention: insights from the Guthrie PCI Registry.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Drug-Eluting Stents; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2009 |
New findings highlight potential risks of common drug combination in cardiac patients.
Topics: Cardiovascular Diseases; Clopidogrel; Contraindications; Drug Interactions; Drug Therapy, Combination; Humans; Proton Pump Inhibitors; Ticlopidine | 2009 |
Rethinking loading dose clopidogrel in light of increased bleeding complications in bypass patients.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine | 2009 |
Prevalence and characteristics of traumatic intracranial hemorrhage in elderly fallers presenting to the emergency department without focal findings.
Topics: Accidental Falls; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Chi-Square Distribution; Clopidogrel; Emergency Service, Hospital; Female; Humans; Intracranial Hemorrhage, Traumatic; Logistic Models; Male; Prevalence; Retrospective Studies; Risk Factors; Ticlopidine; Tomography, X-Ray Computed; Warfarin | 2009 |
Invited commentary.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Female; Graft Occlusion, Vascular; Graft Survival; Humans; Male; Platelet Aggregation Inhibitors; Sensitivity and Specificity; Ticlopidine; Vascular Patency | 2009 |
Adverse outcomes associated with use of proton pump inhibitors and clopidogrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk; Ticlopidine | 2009 |
Adverse outcomes associated with use of proton pump inhibitors and clopidogrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk; Ticlopidine | 2009 |
Adverse outcomes associated with use of proton pump inhibitors and clopidogrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk; Smoking; Ticlopidine | 2009 |
Adverse outcomes associated with use of proton pump inhibitors and clopidogrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk; Ticlopidine | 2009 |
The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Synergism; Female; Flow Cytometry; Humans; Imines; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyridines; Receptor, PAR-1; Thrombosis; Ticlopidine | 2009 |
[Pharmazie in unserer Zeit 4/2009].
Topics: Aspirin; Atherosclerosis; Clopidogrel; Drug Resistance; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticlopidine | 2009 |
[Clinically relevant interaction between clopidogrel and proton pump inhibitors].
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Enzyme Inhibitors; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2009 |
Aspirin for heart attack, stroke prevention. When benefits outweigh risks: four new studies help clarify who should--and who shouldn't--take the drug.
Topics: Aspirin; Clopidogrel; Contraindications; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine | 2009 |
Gastroprotective strategy in aspirin users.
Topics: Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer; Proton Pump Inhibitors; Ticlopidine | 2009 |
[Clopidogrel plus proton pump inhibitor: is infarct risk increased? (interview by Dr. Thomas Meissner)].
Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2009 |
Obesity and cardiovascular thrombotic events in patients undergoing percutaneous coronary intervention with drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Vessel Prosthesis; Body Mass Index; Clopidogrel; Coronary Disease; Death, Sudden, Cardiac; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Obesity; Platelet Aggregation Inhibitors; Retrospective Studies; Thrombosis; Ticlopidine | 2009 |
Premature preoperative discontinuation of antiplatelet drug therapy in cardiovascular risk patients: a preliminary study on the role of P2Y12 receptor monitoring.
Topics: Adult; Aged; Aspirin; Blood Loss, Surgical; Cardiovascular Diseases; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Preoperative Care; Prospective Studies; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors | 2010 |
Stent thrombosis after drug-eluting stent implantation: incidence, timing, and relation to discontinuation of clopidogrel therapy over a 4-year period.
Topics: Aged; Blood Vessel Prosthesis; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2009 |
Co-prescription of gastro-protectants in hospitalized patients: an analysis of what we do and what we think we do.
Topics: Aged; Aged, 80 and over; Aspirin; Attitude of Health Personnel; Clopidogrel; Data Collection; Female; Gastrointestinal Hemorrhage; Hospitals, Teaching; Humans; Male; Middle Aged; Peptic Ulcer; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2010 |
The formation of monocyte-platelet aggregates is independent of on-treatment residual agonists'-inducible platelet reactivity.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Lipopolysaccharide Receptors; Male; Microfilament Proteins; Middle Aged; Monocytes; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Stents; Ticlopidine | 2009 |
[Renal hypertension. A case report - therapeutic dilemmas].
Topics: Adult; Angiography; Angioplasty, Balloon; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Humans; Hypertension, Renal; Kidney; Male; Platelet Aggregation Inhibitors; Renal Artery Obstruction; Ticlopidine; Ultrasonography | 2009 |
[Clopidogrel-associated thrombotic thrombocytopenic purpura].
Topics: ADAM Proteins; ADAMTS13 Protein; Autoantibodies; Cerebral Infarction; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine; von Willebrand Factor | 2009 |
A caution on Plavix and PPIs.
Topics: Clopidogrel; Drug Interactions; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2009 |
CYP2C19*2 polymorphism is not the sole determinant of the response to clopidogrel: implications for its monitoring.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Body Weight; Clopidogrel; Comorbidity; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Monitoring; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polypharmacy; Smoking; Ticlopidine; Vasodilator Agents | 2009 |
Safety and effectiveness of endovascular therapy after 8 hours of acute ischemic stroke onset and wake-up strokes.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Brain Ischemia; Cerebral Arteries; Clopidogrel; Female; Fibrinolytic Agents; Heparin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Retrospective Studies; Stents; Stroke; Thrombectomy; Ticlopidine; Treatment Outcome; Vascular Surgical Procedures | 2009 |
Smoking promotes clopidogrel-mediated platelet inhibition in patients receiving dual antiplatelet therapy.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Smoking; Ticlopidine | 2009 |
Clinical impact of early clopidogrel discontinuation following acute myocardial infarction hospitalization or stent implantation: analysis in a single integrated health network.
Topics: Aged; Algorithms; Cardiovascular Surgical Procedures; Clopidogrel; Cohort Studies; Coronary Disease; Delivery of Health Care, Integrated; Female; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Time Factors; Withholding Treatment | 2009 |
Clinical impact of early clopidogrel discontinuation following acute myocardial infarction hospitalization or stent implantation: analysis in a nationally representative managed-care population.
Topics: Aged; Algorithms; Cardiovascular Surgical Procedures; Clopidogrel; Cohort Studies; Coronary Disease; Female; Hospitalization; Humans; Male; Managed Care Programs; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Population; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Time Factors; United States; Withholding Treatment | 2009 |
Spontaneous spinal epidural hematoma: an urgent complication of adding clopidogrel to aspirin therapy.
Topics: Aspirin; Clopidogrel; Coronary Stenosis; Decompression, Surgical; Drug Interactions; Hematoma, Epidural, Spinal; Humans; Hypertension; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Spinal Cord; Stents; Ticlopidine; Treatment Outcome | 2009 |
Letter by Ryding et al regarding article, "Impact of pretreatment with clopidogrel on initial patency and outcome in patients treated with primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a systematic review".
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Meta-Analysis as Topic; Myocardial Infarction; Ticlopidine; Treatment Outcome; Vascular Patency | 2009 |
Right ventricular function in ST elevation myocardial infarction: effect of reperfusion.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angioplasty, Balloon, Coronary; Atorvastatin; Clopidogrel; Female; Heptanoic Acids; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Pyrroles; Streptokinase; Thrombolytic Therapy; Ticlopidine; Treatment Outcome; Ventricular Function, Right | 2009 |
Radiocephalic fistula complicated by distal ischemia: treatment by ulnar artery dilatation.
Topics: Aged; Angioplasty, Balloon; Arterial Occlusive Diseases; Catheters, Indwelling; Clopidogrel; Diabetes Mellitus, Type 1; Enoxaparin; Female; Hand; Heparin; Humans; Insect Hormones; Ischemia; Peritoneal Dialysis; Ticlopidine; Ulnar Artery | 2010 |
Clopidogrel in ESRD patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Hemorrhage; Humans; Kidney Failure, Chronic; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
New coating stent design for patients with high-risk coronary lesions for thrombotic events: early and long-term results of the Camouflage registry.
Topics: Aged; Argentina; Clopidogrel; Coated Materials, Biocompatible; Coronary Angiography; Coronary Disease; Coronary Thrombosis; Equipment Design; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2009 |
Drug-specific thienopyridine resistance in patient with recurrent coronary stent thrombosis.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Drug Resistance; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Secondary Prevention; Stents; Ticlopidine | 2009 |
[ASS plus clopidogrel in contraindication for marcumar].
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Contraindications; Drug Therapy, Combination; Humans; Intracranial Embolism; Phenprocoumon; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2009 |
[Platelet inhibition remains the second choice. "Anticoagulation should always be the goal" (interview by Dr. med. Jochen Aumiller)].
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Contraindications; Drug Therapy, Combination; Humans; Intracranial Embolism; Phenprocoumon; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2009 |
Usefulness of pretreatment with high-dose clopidogrel in patients undergoing primary angioplasty for ST-elevation myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Premedication; Ticlopidine; Treatment Outcome | 2009 |
Prevalence of aspirin and clopidogrel resistance among patients with and without drug-eluting stent thrombosis.
Topics: Aged; Aspirin; Case-Control Studies; Clopidogrel; Cohort Studies; Coronary Thrombosis; Drug Resistance; Drug-Eluting Stents; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prevalence; Ticlopidine | 2009 |
Platelet reactivity and stent thrombosis: still some issues to solve.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Comorbidity; Coronary Artery Disease; Drug-Eluting Stents; Electrodes; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Assessment; Smoking; Thrombosis; Ticlopidine | 2009 |
Prevalence and risk factors for aspirin and clopidogrel resistance in patients with coronary artery disease or ischemic cerebrovascular disease.
Topics: Aged; Aspirin; Blood Pressure; Cerebral Arterial Diseases; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Hemoglobins; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prevalence; Risk Factors; Ticlopidine | 2009 |
Fibrin clot inhibitor medication and efficacy of bacillus Calmette-Guerin for bladder urothelial cancer.
Topics: Adjuvants, Immunologic; Aged; Anticoagulants; Aspirin; BCG Vaccine; Carcinoma, Transitional Cell; Clopidogrel; Drug Interactions; Female; Fibrinolytic Agents; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Urinary Bladder Neoplasms; Warfarin | 2009 |
Editorial comment.
Topics: Adjuvants, Immunologic; Anticoagulants; Aspirin; BCG Vaccine; Carcinoma, Transitional Cell; Clopidogrel; Drug Interactions; Female; Fibrinolytic Agents; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; Urinary Bladder Neoplasms; Warfarin | 2009 |
Who is ineligible for warfarin in atrial fibrillation?
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Patient Selection; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Warfarin | 2009 |
Testing a no-warfarin heart valve.
Topics: Anticoagulants; Aspirin; Clopidogrel; Heart Valve Diseases; Heart Valve Prosthesis; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2006 |
Calcium-channel blockers decrease clopidogrel-mediated platelet inhibition.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Cardiovascular Diseases; Clopidogrel; Drug Combinations; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine | 2010 |
Test before you stop.
Topics: Adenosine; Algorithms; Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Perioperative Care; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Pyridines; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2009 |
Acute myocardial infarction associated with pregnancy successfully treated with percutaneous coronary intervention.
Topics: Adult; Angioplasty, Balloon, Coronary; Cesarean Section; Clopidogrel; Female; Humans; Infant, Newborn; Myocardial Infarction; Pregnancy; Pregnancy Complications, Cardiovascular; Ticlopidine; Treatment Outcome | 2009 |
Challenge. What is your diagnosis? Answer. Primary nodal diffuse large B-cell lymphoma with secondary cutaneous involvement.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Coronary Artery Disease; Diuretics; Exanthema; Humans; Hydrochlorothiazide; Lisinopril; Lymphoma, Large B-Cell, Diffuse; Male; Platelet Aggregation Inhibitors; Skin Neoplasms; Sotalol; Stents; Ticlopidine | 2009 |
Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis.
Topics: Adenosine; Animals; CHO Cells; Clopidogrel; Cricetinae; Cricetulus; Disease Models, Animal; Dogs; Hemostasis; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine; Transfection | 2009 |
Cardiovascular disease gets personal.
Topics: Anticoagulants; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Female; Genetic Predisposition to Disease; Genetic Testing; Genetic Variation; Genome-Wide Association Study; Genomics; Humans; Pharmacogenetics; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Warfarin | 2009 |
Peri-operative management of anti-platelet agents.
Topics: Aged; Aged, 80 and over; Aspirin; Chi-Square Distribution; Clopidogrel; Female; Humans; Interviews as Topic; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Surgical Procedures, Operative; Ticlopidine; Warfarin | 2009 |
Case of the month. Idiopathic dilated cardiomyopathy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Angiography; Angiotensin-Converting Enzyme Inhibitors; Atorvastatin; Carbazoles; Cardiomyopathy, Dilated; Carvedilol; Clopidogrel; Diuretics; Dyspnea; Echocardiography; Electrocardiography; Furosemide; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lisinopril; Male; Mineralocorticoid Receptor Antagonists; Platelet Aggregation Inhibitors; Potassium; Propanolamines; Pyrroles; Spironolactone; Ticlopidine | 2009 |
The carina angle-new geometrical parameter associated with periprocedural side branch compromise and the long-term results in coronary bifurcation lesions with main vessel stenting only.
Topics: Aged; Analysis of Variance; Antineoplastic Agents, Phytogenic; Clopidogrel; Confidence Intervals; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Coronary Vessels; Drug-Eluting Stents; Everolimus; Female; Humans; Image Interpretation, Computer-Assisted; Immunosuppressive Agents; Male; Mathematics; Multivariate Analysis; Odds Ratio; Paclitaxel; Platelet Aggregation Inhibitors; Poland; Registries; Retrospective Studies; Sirolimus; Statistics as Topic; Ticlopidine; Time Factors | 2009 |
A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel.
Topics: Clopidogrel; Cytochrome P-450 Enzyme System; Genetic Variation; Humans; Microsomes, Liver; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticlopidine | 2009 |
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Chromosomes, Human, Pair 10; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Ethnicity; Female; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine; Treatment Outcome | 2009 |
Tailoring antiplatelet therapy based on pharmacogenomics: how well do the data fit?
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Humans; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Impact of loading dose adjustment on platelet reactivity in homozygotes of the 2C19 2* loss of function polymorphism.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Homozygote; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Ticlopidine | 2010 |
Ticagrelor--is there need for a new player in the antiplatelet-therapy field?
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2009 |
[Scope of the contract for drug therapy. Rebate contracts also for original drugs].
Topics: Clopidogrel; Contracts; Cost Savings; Drug Costs; Drugs, Generic; Germany; Humans; National Health Programs; Pharmaceutical Services; Platelet Aggregation Inhibitors; Prescription Drugs; Ticlopidine | 2009 |
Risk of combining PPIs with thienopyridines: fact or fiction?
Topics: Biotransformation; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Pyridines; Thiophenes; Ticlopidine | 2009 |
Percutaneous coronary intervention in a patient with factor XI deficiency.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Factor XI Deficiency; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2009 |
Risk of adverse clinical outcomes with concomitant use of clopidogrel and proton pump inhibitors following percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Chi-Square Distribution; Clopidogrel; Cohort Studies; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Gastroesophageal Reflux; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Proton Pump Inhibitors; Retrospective Studies; Risk Assessment; Severity of Illness Index; Survival Analysis; Ticlopidine; Treatment Outcome | 2010 |
Effect of blood hematocrit and erythrocyte deformability on adenosine 5'-diphosphate platelet reactivity in patients with acute coronary syndromes on dual antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Blood Viscosity; Clopidogrel; Erythrocyte Deformability; Female; Hematocrit; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
One-year follow-up of nonrandomized comparison between coronary artery bypass grafting surgery and drug-eluting stent for the treatment of unprotected left main coronary artery disease in elderly patients (aged >or=75 years).
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Confidence Intervals; Coronary Artery Bypass; Coronary Artery Disease; Drug-Eluting Stents; Female; Heparin; Humans; Logistic Models; Male; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Prospective Studies; Stroke Volume; Ticlopidine; Time Factors; Ventricular Function, Left | 2009 |
Side balloon stenting of the left main bifurcation: a three-year angiographic follow-up.
Topics: Angioplasty, Balloon, Coronary; Antineoplastic Agents, Phytogenic; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors | 2009 |
Predictive value of post-treatment platelet reactivity for occurrence of post-discharge bleeding after non-ST elevation acute coronary syndrome. Shifting from antiplatelet resistance to bleeding risk assessment?
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Biomarkers; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Intracranial Hemorrhages; Male; Microfilament Proteins; Middle Aged; Patient Discharge; Phosphoproteins; Phosphorylation; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Risk Assessment; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Early stent thrombosis in patients undergoing primary coronary stenting for acute myocardial infarction: incidence, a simple risk score, and prognosis.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Female; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; Shock, Cardiogenic; Stents; Ticlopidine | 2010 |
Early treatment for non-ST-segment elevation acute coronary syndrome is associated with appropriate discharge care.
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug Utilization; Emergency Service, Hospital; Female; Guideline Adherence; Health Care Surveys; Health Services Accessibility; Humans; Male; Middle Aged; Outcome and Process Assessment, Health Care; Patient Discharge; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Registries; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome; United States | 2009 |
Femoral artery complications after cardiac catheterization: a study of patient profile.
Topics: Aged; Anticoagulants; Cardiac Catheterization; Clopidogrel; Coronary Artery Disease; Female; Femoral Artery; Hematoma; Hemorrhage; Hemostatic Techniques; Heparin; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Punctures; Retrospective Studies; Risk Assessment; Risk Factors; Sex Factors; Ticlopidine | 2010 |
Headache as the sole presenting symptom of acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Anticholesteremic Agents; Aspirin; Atorvastatin; Clopidogrel; Headache; Heparin, Low-Molecular-Weight; Heptanoic Acids; Humans; Male; Middle Aged; Myocardial Infarction; Oxygen Inhalation Therapy; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2009 |
A novel strategy for managing clopidogrel-induced adverse skin reactions.
Topics: Angioplasty, Balloon, Coronary; Anti-Allergic Agents; Anti-Inflammatory Agents; Chlorpheniramine; Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prednisolone; Probability; Skin Diseases; Ticlopidine | 2009 |
[Pulmonary haemorrhage and haemothorax after massive ingestion of clopidogrel as a suicide attempt].
Topics: Clopidogrel; Female; Hemorrhage; Hemothorax; Humans; Lung Diseases; Middle Aged; Platelet Aggregation Inhibitors; Suicide, Attempted; Ticlopidine | 2009 |
Antiplatelet agents used for early intervention in acute coronary syndrome: myocardial salvage versus bleeding complications.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Coronary Artery Bypass; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticlopidine | 2009 |
Clopidogrel plus aspirin in atrial fibrillation.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Contraindications; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Vitamin K; Warfarin | 2009 |
Clopidogrel plus aspirin in atrial fibrillation.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Embolism; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Vascular Diseases | 2009 |
Clopidogrel plus aspirin in atrial fibrillation.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Costs; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Risk; Stroke; Ticlopidine | 2009 |
Clopidogrel plus aspirin in atrial fibrillation.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Incidence; Platelet Aggregation Inhibitors; Risk; Stroke; Ticlopidine; Vitamin K; Warfarin | 2009 |
Clopidogrel plus aspirin in atrial fibrillation.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Vitamin K | 2009 |
Clopidogrel plus aspirin in atrial fibrillation.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stroke; Ticlopidine | 2009 |
Triple antiplatelet therapy for clopidogrel resistance with stent malapposition: a case report.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Sirolimus; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2009 |
Are we sure we have taken the best from clopidogrel?
Topics: Clopidogrel; Coronary Restenosis; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Effect of comedication with proton pump inhibitors (PPIs) on post-interventional residual platelet aggregation in patients undergoing coronary stenting treated by dual antiplatelet therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Coronary Artery Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Propensity Score; Proton Pump Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2010 |
Influence of C3435T multidrug resistance gene-1 (MDR-1) polymorphism on platelet reactivity and prognosis in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Acute Disease; Aged; Angioplasty, Balloon, Coronary; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Drug Resistance, Multiple; Female; Gene Frequency; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Risk Assessment; Ticlopidine | 2009 |
Platelet antiaggregants in pregnancy.
Topics: Abciximab; Adult; Antibodies, Monoclonal; Clopidogrel; Coronary Thrombosis; Female; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Cardiovascular; Ticlopidine | 2009 |
Sensitivity enhancement and matrix effect evaluation during summation of multiple transition pairs-case studies of clopidogrel and ramiprilat.
Topics: Chromatography, Liquid; Clopidogrel; Humans; Ramipril; Sensitivity and Specificity; Tandem Mass Spectrometry; Ticlopidine | 2010 |
Desensitization to clopidogrel: a growing need.
Topics: Aspirin; Cardiac Catheterization; Clopidogrel; Desensitization, Immunologic; Drug Therapy, Combination; Humans; Hyperlipidemias; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2010 |
Hunting for the "sweet spot" in P2Y12 receptor blockade.
Topics: Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2009 |
Upper gastrointestinal bleeding in patients receiving dual antiplatelet therapy after coronary stenting.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Disease; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
Comparison of bleeding complications with omega-3 fatty acids + aspirin + clopidogrel--versus--aspirin + clopidogrel in patients with cardiovascular disease.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fatty Acids, Omega-3; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; United States | 2009 |
Clinical benefit of early reperfusion therapy in patients with ST-elevation myocardial infarction usually excluded from randomized clinical trials (results from the Maximal Individual Therapy in Acute Myocardial Infarction Plus [MITRA Plus] registry).
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Electrocardiography; Female; Follow-Up Studies; Germany; Guideline Adherence; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Odds Ratio; Platelet Aggregation Inhibitors; Prospective Studies; Randomized Controlled Trials as Topic; Registries; Ticlopidine; Treatment Outcome | 2009 |
Predictive values of post-treatment adenosine diphosphate-induced aggregation and vasodilator-stimulated phosphoprotein index for stent thrombosis after acute coronary syndrome in clopidogrel-treated patients.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Blood Proteins; Cell Adhesion Molecules; Clopidogrel; Coronary Thrombosis; Electrocardiography; Female; Humans; Male; Microfilament Proteins; Middle Aged; Odds Ratio; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Prosthesis Failure; Risk Factors; ROC Curve; Stents; Ticlopidine | 2009 |
The influence of clinical characteristics, laboratory and inflammatory markers on 'high on-treatment platelet reactivity' as measured with different platelet function tests.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Platelets; Cells, Cultured; Clopidogrel; Drug Combinations; Female; Humans; Interleukin-6; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Sensitivity and Specificity; Thrombosis; Ticlopidine | 2009 |
Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness.
Topics: Aspirin; Blood Platelets; Cells, Cultured; Clopidogrel; Drug Combinations; Feasibility Studies; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Reproducibility of Results; Thrombosis; Ticlopidine; Treatment Outcome | 2009 |
An unusual case of recurrent fever, jaundice and right upper quadrant pain.
Topics: Abdominal Pain; Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Fever; Humans; Jaundice; Liver; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Medical treatment of patients with intracranial atherosclerotic disease.
Topics: Anticoagulants; Aspirin; Atherosclerosis; Brain Ischemia; Cilostazol; Clopidogrel; Dipyridamole; Embolism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Arteriosclerosis; Intracranial Thrombosis; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Risk Factors; Tetrazoles; Ticlopidine | 2009 |
Cilostazol, a phosphodiesterase inhibitor, attenuates photothrombotic focal ischemic brain injury in hypertensive rats.
Topics: Animals; Aspirin; Brain Ischemia; Cells, Cultured; Cerebrovascular Circulation; Cilostazol; Clopidogrel; Endothelial Cells; Epoprostenol; Humans; Hypertension; Laser-Doppler Flowmetry; Male; Nitric Oxide; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred SHR; Tetrazoles; Ticlopidine | 2010 |
Effects of clopidogrel on "aspirin specific" pathways of platelet inhibition.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Drug Interactions; Female; Humans; Male; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats.
Topics: Acetylcholine; Adenosine Diphosphate; Angiotensin II; Animals; Blotting, Western; Clopidogrel; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Ticlopidine; Vasodilation; Vasodilator Agents | 2010 |
Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions.
Topics: Adolescent; Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Graft Occlusion, Vascular; Humans; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome; Young Adult | 2010 |
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Biotransformation; Cell Line; Cell Line, Tumor; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Humans; Ketoconazole; Kinetics; Mephenytoin; Microsomes; Microsomes, Liver; NADP; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Sulfaphenazole; Theophylline; Ticlopidine | 2010 |
[New thrombocyte inhibitor. Fewer ischemic complications in acute coronary syndrome].
Topics: Acute Coronary Syndrome; Clopidogrel; Double-Blind Method; Humans; Myocardial Ischemia; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2009 |
Adenosine diphosphate-inducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel.
Topics: Adenosine Diphosphate; Age Factors; Aged; Aged, 80 and over; Angioplasty, Balloon; Blood Platelets; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Female; Humans; Linear Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Stents; Ticlopidine | 2010 |
Assessment of platelet response to clopidogrel with multiple electrode aggregometry, the VerifyNow P2Y12 analyzer and platelet Vasodilator-Stimulated Phosphoprotein flow cytometry.
Topics: Adenosine Diphosphate; Aged; Cell Adhesion Molecules; Clopidogrel; Coronary Angiography; Electric Impedance; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Nephelometry and Turbidimetry; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Protein Processing, Post-Translational; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Reproducibility of Results; Ticlopidine | 2010 |
Routine early angioplasty after fibrinolysis.
Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Humans; Myocardial Infarction; Patient Transfer; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine; Time Factors | 2009 |
Potential unrecognised costs of clopidogrel pretreatment in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; American Heart Association; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Costs and Cost Analysis; Female; Guideline Adherence; Humans; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Guidelines as Topic; Retrospective Studies; Ticlopidine; Time Factors; United States | 2009 |
Evaluation of hospitalization and follow-up care costs among patients hospitalized with ACS treated with a stent and clopidogrel.
Topics: Acute Coronary Syndrome; Cardiovascular Surgical Procedures; Clopidogrel; Female; Follow-Up Studies; Health Care Costs; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine | 2009 |
Platelet aggregation in intracranial stents may mimic in-stent restenosis.
Topics: Cerebral Angiography; Clopidogrel; Diagnosis, Differential; Drug Resistance; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Failure | 2010 |
Reduced platelet activity is associated with more intraventricular hemorrhage.
Topics: Adult; Aged; Aspirin; Blood Platelet Disorders; Blood Platelets; Cerebral Hemorrhage; Clopidogrel; Cohort Studies; Comorbidity; Disease Progression; Female; Humans; Lateral Ventricles; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2009 |
Evaluation of clopidogrel responsiveness after drug-eluting stent implantation.
Topics: Blood Platelets; Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Patient characteristics associated with the choice of triple antithrombotic therapy in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Anemia; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Atrial Flutter; Clopidogrel; Diabetes Mellitus; Drug Therapy, Combination; Drug Utilization; Female; Humans; Logistic Models; Male; Middle Aged; Patient Discharge; Platelet Aggregation Inhibitors; Registries; Smoking; Stents; Stroke; Stroke Volume; Ticlopidine; United States; Warfarin | 2009 |
Prevalence of unresponsiveness to aspirin and/or clopidogrel in patients with stable coronary heart disease.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Ticlopidine | 2009 |
A comparison of aspirin and clopidogrel with or without proton pump inhibitors for the secondary prevention of cardiovascular events in patients at high risk for gastrointestinal bleeding.
Topics: Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Databases, Factual; Drug Costs; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Patient Readmission; Peptic Ulcer; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Secondary Prevention; Taiwan; Ticlopidine | 2009 |
Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Kinetics; Microsomes, Liver; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
Effect of clopidogrel on perioperative blood loss and transfusion in coronary artery bypass graft surgery.
Topics: Aged; Aspirin; Blood Transfusion; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Hemorrhage; Humans; Length of Stay; Male; Middle Aged; Patient Selection; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
[Basic examination before clinical examination. That is why it is worthwhile to return to the laboratory].
Topics: Aspirin; Biomarkers; Blood Coagulation; CD40 Ligand; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Punctures; Thrombin; Ticlopidine; Veins | 2009 |
Clinical management of clopidogrel inefficiency by point of care platelet function testing and individual adjustment of anti-platelet therapy--initial experiences.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Electric Impedance; Female; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Ticlopidine | 2009 |
The relation between platelet reactivity and glycemic control in diabetic patients with cardiovascular disease on maintenance aspirin and clopidogrel therapy.
Topics: Adult; Aged; Aspirin; Blood Glucose; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Stent thrombosis: who's guilty?
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Blood Vessel Prosthesis; Cardiology; Clinical Competence; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Graft Occlusion, Vascular; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Ticlopidine | 2009 |
Correlation of inhibition of platelet aggregation after clopidogrel with post discharge bleeding events: assessment by different bleeding classifications.
Topics: Aged; Blood Coagulation Tests; Clopidogrel; Coronary Artery Disease; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2010 |
Familial Takayasu's arteritis in female siblings.
Topics: Adult; Aorta, Thoracic; Aspirin; Clopidogrel; Family Health; Female; Genetic Predisposition to Disease; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Artery; Siblings; Takayasu Arteritis; Ticlopidine; Tomography, X-Ray Computed | 2011 |
Time does not heal every wound: coronary stent thrombosis of a bare-metal stent more than one decade after its implantation.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2009 |
Clopidogrel and calcium-channel blockers: a clinically important interaction?
Topics: Calcium Channel Blockers; Clopidogrel; Coronary Artery Disease; Drug Combinations; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Platelet-bound P-selectin expression in patients with coronary artery disease: impact on clinical presentation and myocardial necrosis, and effect of diabetes mellitus and anti-platelet medication.
Topics: Acute Coronary Syndrome; Angina Pectoris; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Coronary Artery Disease; Creatine Kinase, MB Form; Diabetes Mellitus; Drug Therapy, Combination; Flow Cytometry; Humans; Myocardium; Necrosis; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Treatment Outcome; Troponin I; Up-Regulation | 2010 |
Reduced intimal hyperplasia in rabbits via medical therapy after carotid venous bypass.
Topics: Administration, Oral; Animals; Atorvastatin; Benzopyrans; Calcium Dobesilate; Cardiovascular Agents; Carotid Stenosis; Clopidogrel; Disease Models, Animal; Ethanolamines; Graft Occlusion, Vascular; Heptanoic Acids; Hyperplasia; Jugular Veins; Male; Nebivolol; Pyrroles; Rabbits; Ticlopidine; Tunica Intima; Vascular Surgical Procedures | 2009 |
Prasugrel: new drug. After angioplasty and stenting: continue to use aspirin + clopidogrel.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Drug-Eluting Stents; Europe; Hemorrhage; Humans; Ischemic Attack, Transient; Myocardial Infarction; Neoplasms; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Recurrence; Stents; Stroke; Thiophenes; Ticlopidine; Treatment Outcome | 2009 |
Risk and benefit of proton pump inhibitor for patients undergoing anti-platelet therapy including clopidogrel.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Drug-Eluting Stents; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2009 |
Antiplatelet therapy after coronary intervention in Asia and Japan: the Asian perspective of antiplatelet intervention.
Topics: Asia; Cerebral Hemorrhage; Cerebrovascular Disorders; Cilostazol; Clopidogrel; Coronary Disease; Europe; Humans; Liver; North America; Platelet Aggregation Inhibitors; Pyridines; Tetrazoles; Ticlopidine | 2009 |
Glycoprotein IIb/IIIa antagonists: new developments.
Topics: Abciximab; Acute Coronary Syndrome; Antibodies, Monoclonal; Atherectomy; Clinical Trials as Topic; Clopidogrel; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine | 2009 |
Individualized antiplatelet therapy: what can a clinical score contribute?
Topics: Adult; Aged; Clopidogrel; Coronary Disease; Coronary Vessels; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Assessment; Safety; Ticlopidine; Young Adult | 2009 |
Platelet monitoring for PCI: which test is the one to choose?
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Clopidogrel; Electric Impedance; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Thromboxane B2; Ticlopidine | 2009 |
Perioperative clopidogrel is seven days enough?
Topics: Adult; Aged; Aged, 80 and over; Blood Transfusion; Clopidogrel; Cohort Studies; Drug Administration Schedule; Female; Hemostasis, Surgical; Humans; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Ticlopidine; Treatment Outcome | 2009 |
[Changing times for clopidogrel].
Topics: Clopidogrel; Drug Interactions; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Purinergic P2 Receptor Antagonists; Thiophenes; Ticlopidine | 2009 |
Pro: "Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation".
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clinical Trials as Topic; Clopidogrel; Contraindications; Drug Therapy, Combination; Hemorrhage; Humans; International Normalized Ratio; Intracranial Embolism; Middle Aged; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Risk Factors; Severity of Illness Index; Thrombophilia; Ticlopidine; Warfarin | 2009 |
Contra: "Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation".
Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clinical Trials as Topic; Clopidogrel; Contraindications; Drug Therapy, Combination; Hemorrhage; Humans; Intracranial Embolism; Middle Aged; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Risk Factors; Severity of Illness Index; Thrombophilia; Ticlopidine; Vitamin K; Warfarin | 2009 |
Clopidogrel application: beyond coronary artery disease.
Topics: Animals; Clopidogrel; Hypertension; Male; Mesenteric Arteries; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2010 |
Effectiveness of two-year clopidogrel + aspirin in abolishing the risk of very late thrombosis after drug-eluting stent implantation (from the TYCOON [two-year ClOpidOgrel need] study).
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stents; Ticlopidine; Time Factors | 2009 |
Fatal liver injury associated with clopidogrel.
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Fatal Outcome; Humans; Liver Function Tests; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Poor performance with a platelet counting technique to monitor clopidogrel inhibitory effects in the point-of-care setting.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Platelet Count; Point-of-Care Systems; Reproducibility of Results; Sensitivity and Specificity; Sweden; Thrombosis; Ticlopidine | 2010 |
Platelet function analysis: a comparison of methods.
Topics: Aged; Clopidogrel; Female; Flow Cytometry; Humans; Male; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Ticlopidine | 2010 |
Perioperative management of the patient with a coronary stent.
Topics: Algorithms; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Graft Occlusion, Vascular; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Time Factors | 2010 |
A comparison of the VASP index between patients with hemodynamically complicated and uncomplicated acute myocardial infarction.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Biomarkers; Blood Platelets; Case-Control Studies; Catecholamines; Cell Adhesion Molecules; Clopidogrel; Down-Regulation; Drug Monitoring; Female; Hemodynamics; Humans; International Normalized Ratio; Liver Circulation; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Respiration, Artificial; Shock, Cardiogenic; Splanchnic Circulation; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Gender and responses to aspirin and clopidogrel: insights using short thrombelastography.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Sex Characteristics; Thrombelastography; Ticlopidine | 2009 |
Thirty-day outcome following carotid artery stenting: a 10-year experience from a single center.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Angiography; Carotid Stenosis; Clopidogrel; Comorbidity; Endarterectomy, Carotid; Female; Humans; Hyperlipidemias; Hypertension; Logistic Models; Male; Middle Aged; Premedication; Prognosis; Retrospective Studies; Risk Factors; Stents; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome | 2010 |
Women are like men ... Sometimes.
Topics: Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Prevalence; Sex Factors; Ticlopidine; Treatment Outcome | 2009 |
Impact of P2Y12-ADP receptor polymorphism on the efficacy of clopidogrel dose-adjustment according to platelet reactivity monitoring in coronary artery disease patients.
Topics: Aged; Alleles; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Coronary Disease; Female; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Polymorphism, Genetic; Prospective Studies; Receptors, Purinergic P2; Social Adjustment; Ticlopidine | 2010 |
High residual platelet reactivity after clopidogrel loading and long-term clinical outcome after drug-eluting stenting for unprotected left main coronary disease.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Death, Sudden, Cardiac; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk Factors; Ticlopidine | 2009 |
Letter by Kan et al regarding Article, "randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart failure (WATCH) trial".
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Chronic Disease; Clopidogrel; Death; Double-Blind Method; Female; Fibrinolytic Agents; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Stroke; Stroke Volume; Ticlopidine; Warfarin | 2009 |
Pharmacogenetic testing for clopidogrel using the rapid INFINITI analyzer: a dose-escalation study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Drug Resistance; Equipment Design; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Precision Medicine; Predictive Value of Tests; Randomized Controlled Trials as Topic; Retrospective Studies; Ticlopidine; Time Factors | 2009 |
The worry about clopidogrel "nonresponsiveness": identification and treatment in the post-percutaneous coronary intervention patient.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Drug Resistance; Gene Frequency; Genotype; Humans; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Precision Medicine; Predictive Value of Tests; Ticlopidine; Time Factors | 2009 |
By the way, doctor. I am currently on Coumadin because I had atrial fibrillation after my bypass, Plavix because of my stent, and a baby aspirin. Why do I need to take three blood thinners?
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Cardiopulmonary Bypass; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2009 |
Potential Interaction between clopidogrel and proton pump inhibitors.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Thrombosis; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2009 |
Low platelet disaggregation predicts poor response to 150 mg clopidogrel in patients with elevated platelet reactivity.
Topics: Aged; Blood Platelet Disorders; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
ProFESS trial: any lessons to learn for future anti-platelet trials?
Topics: Aged; Aspirin; Brain; Cerebral Arteries; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Risk Reduction Behavior; Stroke; Ticlopidine | 2009 |
Aspirin and clopidogrel use in the early postoperative period following on-pump and off-pump coronary artery bypass grafting.
Topics: Adult; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Period; Ticlopidine | 2009 |
Is it possible to safely administer early a loading dose of clopidogrel before coronary angiography to patients who are candidates for percutaneous coronary intervention?
Topics: Acute Coronary Syndrome; Adult; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Artery Bypass; Feasibility Studies; Female; Humans; Logistic Models; Male; Medical Records; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Predictive Value of Tests; Preoperative Care; Sensitivity and Specificity; Ticlopidine; Treatment Outcome | 2009 |
Relation of body mass index to high on-treatment platelet reactivity and of failed clopidogrel dose adjustment according to platelet reactivity monitoring in patients undergoing percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Body Mass Index; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Diabetes Complications; Dose-Response Relationship, Drug; Female; France; Genetic Markers; Genotype; Humans; Male; Middle Aged; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Predictive Value of Tests; Prospective Studies; Risk Factors; Ticlopidine | 2009 |
Proton pump inhibitors and clopidogrel: putting the interaction in perspective.
Topics: Clopidogrel; Drug Interactions; Humans; Proton Pump Inhibitors; Ticlopidine | 2009 |
Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Databases, Factual; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Proton Pump Inhibitors; Risk Factors; Ticlopidine; Treatment Outcome | 2009 |
Costs and consequences of direct-to-consumer advertising for clopidogrel in Medicaid.
Topics: Advertising; Clopidogrel; Consumer Behavior; Drug Costs; Health Expenditures; Humans; Information Dissemination; Mass Media; Medicaid; Patient Participation; Pharmacies; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Ticlopidine; United States | 2009 |
Therapeutic innovations, diminishing returns, and control rate preservation.
Topics: Angioplasty, Balloon, Coronary; Biomarkers; Cardiovascular Agents; Clopidogrel; Diagnosis, Differential; Electrocardiography; Evidence-Based Medicine; Humans; International Cooperation; Metoprolol; Myocardial Infarction; Randomized Controlled Trials as Topic; Streptokinase; Therapeutics; Ticlopidine; Treatment Outcome; Troponin | 2009 |
Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Female; Genetic Variation; Genotype; Haplotypes; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Stents; Ticlopidine | 2010 |
Antiplatelet therapy: Ticagrelor in ACS-what does PLATO teach us?
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty, Balloon, Coronary; Clinical Trials, Phase III as Topic; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine; Treatment Outcome | 2009 |
Aspirin gets a backup against atrial fibrillation.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2009 |
Clopidogrel and proton pump inhibitors: Are the goal posts shifting?
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Multiple electrode aggregometry predicts stent thrombosis better than the vasodilator-stimulated phosphoprotein phosphorylation assay.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Electrodes; Female; Humans; Logistic Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; ROC Curve; Sensitivity and Specificity; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Germany; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Risk Assessment; Risk Factors; ROC Curve; Severity of Illness Index; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Clopidogrel versus prasugrel: times are changing, but not for everyone.
Topics: Acute Coronary Syndrome; Clinical Trials as Topic; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
The management of patients with hip fractures who are taking Clopidogrel.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Hip Fractures; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors | 2009 |
Prasugrel for acute coronary syndromes: faster, more potent, but higher bleeding risk.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Hemorrhage; Humans; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2009 |
There is no place like home after successful percutaneous coronary intervention.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Evidence-Based Medicine; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Infusions, Parenteral; Injections; Length of Stay; Myocardial Infarction; Patient Discharge; Platelet Aggregation Inhibitors; Radial Artery; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Concomitant use of clopidogrel and proton pump inhibitors or cimetidine after acute myocardial infarction would increase the risk of re-infarction.
Topics: Alleles; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Cimetidine; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Humans; Male; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Taiwan; Ticlopidine | 2009 |
Underutilization of clopidogrel and glycoprotein IIb/IIIa inhibitors in non-ST-elevation acute coronary syndrome patients: the Canadian global registry of acute coronary events (GRACE) experience.
Topics: Acute Coronary Syndrome; Aged; Canada; Clopidogrel; Drug Utilization; Female; Guideline Adherence; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Registries; Retrospective Studies; Ticlopidine | 2009 |
Association of platelet responsiveness with clopidogrel metabolism: role of compliance in the assessment of "resistance".
Topics: Aged; Blood Platelets; Brain Ischemia; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Ticlopidine | 2009 |
Aortic thromboembolism successfully treated with anticoagulation and antiplatelet therapy.
Topics: Anticoagulants; Aorta, Thoracic; Arm; Clopidogrel; Coronary Artery Disease; Echocardiography, Transesophageal; Humans; Ischemia; Male; Middle Aged; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine; Warfarin | 2009 |
Dual antiplatelet therapy in patients requiring urgent coronary artery bypass grafting surgery: a position statement of the Canadian Cardiovascular Society.
Topics: Acute Coronary Syndrome; Aspirin; Canada; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Health Planning Guidelines; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Societies, Medical; Ticlopidine; Treatment Outcome | 2009 |
Stent thrombosis: a poor man's disease?
Topics: Acute Disease; Aged; Angioplasty, Balloon, Coronary; Chi-Square Distribution; Clopidogrel; Cohort Studies; Coronary Disease; Data Interpretation, Statistical; Diabetes Complications; Drug-Eluting Stents; Female; Follow-Up Studies; Housing; Humans; Male; Metals; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polytetrafluoroethylene; Residential Facilities; Risk Factors; Smoking; Socioeconomic Factors; Stents; Thrombosis; Ticlopidine; Time Factors | 2009 |
A regional system for delivery of primary percutaneous coronary intervention in ST-elevation myocardial infarction: STEMI-St. Cloud.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Delivery of Health Care; Electrocardiography; Female; Follow-Up Studies; Heparin; Humans; Male; Middle Aged; Minnesota; Myocardial Infarction; Patient Transfer; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2009 |
Clinical trial update II: TRITON-TIMI 38 provides reassurance on concomitant use of proton pump inhibitors and thienopyridines.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2009 |
Interaction between clopidogrel and proton pump inhibitors: hypothesis to explain multifactorial CYP2C19 inhibition.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2009 |
The role of transcranial Doppler embolic monitoring in the management of intracranial arterial stenosis.
Topics: Angiography, Digital Subtraction; Aspirin; Atorvastatin; Blood Flow Velocity; Cerebral Angiography; Clopidogrel; Constriction, Pathologic; Diagnosis, Differential; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Embolism; Ischemic Attack, Transient; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine; Tomography, X-Ray Computed; Ultrasonography, Doppler, Transcranial; Young Adult | 2011 |
[Proton pump inhibitors and clopidogrel in a patient with cardiovascular risk factors: Cardiovascular versus gastrointestinal risk?].
Topics: Algorithms; Cardiovascular Diseases; Clopidogrel; Gastrointestinal Diseases; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2010 |
The right oral antithrombotics in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aspirin; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine; Vitamin K | 2009 |
Risk of bleeding in patients with acute myocardial infarction treated with different combinations of aspirin, clopidogrel, and vitamin K antagonists in Denmark: a retrospective analysis of nationwide registry data.
Topics: Adult; Aged; Aspirin; Clopidogrel; Denmark; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Patient Admission; Proportional Hazards Models; Recurrence; Registries; Retrospective Studies; Risk Factors; Ticlopidine; Vitamin K | 2009 |
Ticagrelor versus clopidogrel in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Dyspnea; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticagrelor; Ticlopidine | 2009 |
The PLATO trial: do you believe in magic?
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials, Phase III as Topic; Clopidogrel; Humans; Intracranial Hemorrhages; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Clopidogrel hypersensitivity: a novel multi-day outpatient oral desensitization regimen.
Topics: Administration, Oral; Adult; Aged; Clopidogrel; Desensitization, Immunologic; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2010 |
Enhanced post-clopidogrel platelet reactivity in diabetic patients is independently related to plasma fibrinogen level but not to glycemic control.
Topics: Blood Glucose; Clopidogrel; Diabetes Mellitus; Fibrinogen; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2009 |
eComment: Controversies on the antiplatelet therapy before coronary artery bypass grafting surgery.
Topics: Aspirin; Blood Transfusion; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Hemorrhage; Humans; Patient Selection; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Triple antithrombotic management after stent implantation: when and how?
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2010 |
The TRITON versus PLATO trials: differences beyond platelet inhibition.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials as Topic; Clopidogrel; Drug Evaluation; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Clopidogrel-associated acute arthritis.
Topics: Acute Disease; Arthralgia; Arthritis; Bursitis; Clopidogrel; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Shoulder Joint; Ticlopidine | 2012 |
Cost-effectiveness of prasugrel versus clopidogrel in patients with acute coronary syndromes and planned percutaneous coronary intervention: results from the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with Prasug
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Cost-Benefit Analysis; Databases, Factual; Drug Costs; Follow-Up Studies; Hemorrhage; Hospitalization; Humans; Life Expectancy; Multicenter Studies as Topic; Myocardial Infarction; Outcome and Process Assessment, Health Care; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Stroke; Thiophenes; Thrombolytic Therapy; Ticlopidine; United States | 2010 |
Antiplatelet drugs for patients at high cardiovascular risk. Aspirin generally remains the best choice.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Atrial Fibrillation; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Risk; Stents; Stroke; Thromboembolism; Thrombosis; Ticlopidine; Warfarin | 2009 |
Comment: Drug-drug interaction between clopidogrel and the proton pump inhibitors.
Topics: Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Common variation in the platelet receptor P2RY12 gene is associated with residual on-clopidogrel platelet reactivity in patients undergoing elective percutaneous coronary interventions.
Topics: Aged; Blood Platelets; Clopidogrel; Cohort Studies; Coronary Artery Disease; Genetic Variation; Humans; Intraoperative Complications; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Premedication; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine | 2009 |
Should dual antiplatelet therapy after drug-eluting stents be continued for more than 1 year?: Dual antiplatelet therapy after drug-eluting stents should be continued for more than one year and preferably indefinitely.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2008 |
Should dual antiplatelet therapy after drug-eluting stents be continued for more than 1 year?: Dual antiplatelet therapy after drug-eluting stents should not be continued for more than 1 year and preferably indefinitely.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2008 |
Frequency of allergic or hematologic adverse reactions to ticlopidine among patients with allergic or hematologic adverse reactions to clopidogrel.
Topics: Aged; Angioedema; Clopidogrel; Drug Hypersensitivity; Exanthema; Female; Humans; Male; Neutropenia; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Severity of Illness Index; Thrombocytopenia; Ticlopidine; United States | 2009 |
Clopidogrel for the hot patient.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; C-Reactive Protein; Clopidogrel; Drug Therapy, Combination; Humans; Inflammation; Inflammation Mediators; Myocardial Infarction; Platelet Aggregation Inhibitors; Predictive Value of Tests; Pregnancy-Associated Plasma Protein-A; Risk Assessment; Stroke; Ticlopidine; Time Factors; Treatment Outcome; Up-Regulation | 2009 |
Relationship between baseline inflammatory markers, antiplatelet therapy, and adverse cardiac events after percutaneous coronary intervention: an analysis from the clopidogrel for the reduction of events during observation trial.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; C-Reactive Protein; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Inflammation; Inflammation Mediators; Kaplan-Meier Estimate; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Predictive Value of Tests; Pregnancy-Associated Plasma Protein-A; Proportional Hazards Models; Prospective Studies; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Stroke; Ticlopidine; Time Factors; Treatment Outcome; United States; Up-Regulation | 2009 |
Improved clinical outcome after acute myocardial infarction in hospitals participating in a Swedish quality improvement initiative.
Topics: Aged; Clopidogrel; Female; Fibrinolytic Agents; Follow-Up Studies; Guideline Adherence; Hemorrhage; Hospital Mortality; Hospitals; Humans; Incidence; Male; Myocardial Infarction; Outcome Assessment, Health Care; Patient Readmission; Prevalence; Quality Assurance, Health Care; Quality of Health Care; Sweden; Ticlopidine | 2009 |
Imaging of structural changes in endothelial cells and thrombus formation at the site of FeCl(3)-induced injuries in mice cremasteric arteries.
Topics: Animals; Arteries; Aspirin; Blood Platelets; Chlorides; Clopidogrel; Dose-Response Relationship, Drug; Endothelial Cells; Ferric Compounds; Leukocytes; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2009 |
Which platelet function test is suitable to monitor clopidogrel responsiveness? A pharmacokinetic analysis on the active metabolite of clopidogrel.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Biotransformation; Blood Platelets; Cell Adhesion Molecules; Chromatography, Liquid; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Flow Cytometry; Humans; Linear Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Tandem Mass Spectrometry; Ticlopidine | 2010 |
Frontiers in platelet inhibition.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Models, Biological; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Ticlopidine | 2009 |
Acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Critical Pathways; Electrocardiography; Emergency Treatment; Guideline Adherence; Humans; Patient Selection; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Assessment; Ticlopidine | 2009 |
Guidelines for the management of antiplatelet therapy in patients with coronary stents undergoing non-cardiac surgery.
Topics: Anticoagulants; Aspirin; Australia; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Heparin; Humans; New Zealand; Platelet Aggregation Inhibitors; Preoperative Care; Ticlopidine | 2010 |
Ticagrelor versus clopidogrel in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticagrelor; Ticlopidine | 2009 |
Ticagrelor versus clopidogrel in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Coronary Artery Bypass; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Stroke; Ticagrelor; Ticlopidine | 2009 |
Ticagrelor versus clopidogrel in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Research Design; Ticagrelor; Ticlopidine | 2009 |
[Abdominal tumor after persistent coughing and uncontrolled anticoagulation].
Topics: Abdomen, Acute; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Colonic Pseudo-Obstruction; Comorbidity; Cough; Dalteparin; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hematoma; Humans; Intracranial Embolism; Phenprocoumon; Rectus Abdominis; Ticlopidine | 2010 |
[Antiplatelet therapy and urgent surgical procedures. Acute appendicitis two days after stent implantation--a case report].
Topics: Appendicitis; Clopidogrel; Coronary Thrombosis; Dobutamine; Humans; Intraoperative Complications; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Reoperation; Stents; Ticlopidine | 2009 |
Cardiac masses in a patient with AJCC stage II melanoma: cautious interpretation of the magnetic resonance imaging.
Topics: Aged; Clopidogrel; Hematoma; Humans; Magnetic Resonance Imaging; Male; Mediastinal Diseases; Mediastinal Neoplasms; Melanoma; Neoplasm Regression, Spontaneous; Platelet Aggregation Inhibitors; Skin Neoplasms; Ticlopidine | 2009 |
Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Contraindications; Dipyridamole; Drug Incompatibility; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Fibrinolytic Agents; Humans; Incidence; Injections, Intravenous; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Assessment; Stroke; Ticlopidine; Tissue Plasminogen Activator; Treatment Outcome; Young Adult | 2010 |
The relationship between warfarin, aspirin, and clopidogrel continuation in the peri-procedural period and the incidence of hematoma formation after device implantation.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Defibrillators, Implantable; Female; Hematoma; Humans; International Normalized Ratio; Male; Pacemaker, Artificial; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prosthesis Implantation; Retrospective Studies; Ticlopidine; Warfarin | 2010 |
Impact of clopidogrel use on mortality and major bleeding in patients undergoing coronary artery bypass surgery.
Topics: Analysis of Variance; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Artery Bypass; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Emergency Treatment; Female; Follow-Up Studies; Hospital Mortality; Humans; Logistic Models; Male; Multivariate Analysis; Postoperative Complications; Postoperative Hemorrhage; Reference Values; Retrospective Studies; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Survival Rate; Ticlopidine | 2010 |
Cost-effectiveness of clopidogrel in STEMI patients in the Netherlands: a model based on the CLARITY trial.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Costs and Cost Analysis; Female; Humans; Male; Models, Theoretical; Multicenter Studies as Topic; Myocardial Infarction; Netherlands; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
A validated stability-indicating normal phase LC method for clopidogrel bisulfate and its impurities in bulk drug and pharmaceutical dosage form.
Topics: Calibration; Chromatography, Liquid; Clopidogrel; Drug Contamination; Drug Stability; Fibrinolytic Agents; Guidelines as Topic; Hydrogen-Ion Concentration; Hydrolysis; Isomerism; Oxidation-Reduction; Photolysis; Platelet Aggregation Inhibitors; Reproducibility of Results; Tablets; Technology, Pharmaceutical; Temperature; Ticlopidine | 2010 |
Subacute coronary stent thrombosis in a patient with angina treated with double antiplatelet drugs for six days.
Topics: Adult; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2009 |
Ticagrelor in ACS: redefining a new standard of care?
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2010 |
Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Gene Frequency; Genotype; Hemorrhage; Heterozygote; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2010 |
Genotyping, clopidogrel metabolism, and the search for the therapeutic window of thienopyridines.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Gene Frequency; Genotype; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Pyridines; Ticlopidine | 2010 |
Therapeutic effect of clopidogrel on cutaneous polyarteritis nodosa.
Topics: Adult; Biopsy; Clopidogrel; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Middle Aged; Platelet Aggregation Inhibitors; Polyarteritis Nodosa; Skin; Ticlopidine | 2010 |
Prostacyclin receptor stimulation facilitates detection of human platelet P2Y(12) receptor inhibition by the PFA-100 system.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Flow Cytometry; Humans; Iloprost; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Epoprostenol; Receptors, Purinergic P2Y12; Ticlopidine; Young Adult | 2010 |
Antiplatelet effect of 50-mg maintenance dose of clopidogrel compared to 200 mg ticlopidine: a preliminary study.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Asian People; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Humans; Japan; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Risk profile and benefits from Gp IIb-IIIa inhibitors among patients with ST-segment elevation myocardial infarction treated with primary angioplasty: a meta-regression analysis of randomized trials.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Meta-Analysis as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Failure | 2010 |
Platelet activation in essential hypertension: implications for antiplatelet treatment.
Topics: Antihypertensive Agents; Blood Platelet Disorders; Blood Platelets; Clopidogrel; Humans; Hypertension; Platelet Activation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2010 |
Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression.
Topics: Adenosine Diphosphate; Aged; Angina, Unstable; Anxiety Disorders; Aspirin; Clopidogrel; Cross-Sectional Studies; Depressive Disorder; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, G-Protein-Coupled; Serotonin; Ticlopidine | 2010 |
Initial experience with dual antiplatelet thromboprophylaxis using clopidogrel and aspirin in patients with mechanical aortic prostheses.
Topics: Aged; Aortic Valve; Aspirin; Blood Platelets; Clopidogrel; Drug Combinations; Female; Follow-Up Studies; Heart Diseases; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Puerto Rico; Thromboembolism; Ticlopidine; United States | 2009 |
Efficacy of high-dose clopidogrel treatment (600 mg) less than two hours before percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Electrocardiography; Female; Follow-Up Studies; Hospital Mortality; Humans; Incidence; Male; Medical Records; Middle Aged; Myocardial Infarction; New York City; Platelet Aggregation Inhibitors; Preoperative Care; Retrospective Studies; Survival Rate; Ticlopidine | 2010 |
Relation of endothelial function to residual platelet reactivity after clopidogrel in patients with stable angina pectoris undergoing percutaneous coronary intervention.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Endothelium, Vascular; Female; Humans; Male; Manometry; Middle Aged; P-Selectin; Platelet Aggregation Inhibitors; Prospective Studies; Severity of Illness Index; Ticlopidine; Time Factors; Treatment Failure; Treatment Outcome; Troponin T | 2010 |
Clopidogrel increases blood transfusion and hemorrhagic complications in patients undergoing cardiac surgery.
Topics: Aged; Aged, 80 and over; Blood Transfusion; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Drug Administration Schedule; Female; Heart Valve Prosthesis Implantation; Humans; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Retrospective Studies; Risk; Risk Factors; Ticlopidine | 2010 |
Highlights from Transcatheter Cardiovascular Therapeutics 2009: San Francisco, California, September 21 to 25, 2009.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Cardiac Surgical Procedures; Clinical Trials as Topic; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Heart Valve Diseases; Humans; Myocardial Revascularization; Platelet Aggregation Inhibitors; Retreatment; Stents; Ticlopidine; Treatment Outcome | 2010 |
Stent thrombosis after drug-eluting stent implantation: incidence, timing, and relation to discontinuation of clopidogrel therapy over a 4-year period.
Topics: Blood Vessel Prosthesis; Clopidogrel; Drug-Eluting Stents; Graft Occlusion, Vascular; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Benefit assessment in Germany.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Comparative Effectiveness Research; Germany; Government Agencies; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; National Health Programs; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2010 |
Combination therapy with clopidogrel and proton-pump inhibitors.
Topics: Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Combination therapy with clopidogrel and proton-pump inhibitors.
Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Influence of microenvironment pH, humidity, and temperature on the stability of polymorphic and amorphous forms of clopidogrel bisulfate.
Topics: Clopidogrel; Dosage Forms; Humidity; Temperature; Ticlopidine | 2010 |
Safety of carotid endarterectomy while on clopidogrel (Plavix). Clinical article.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Clopidogrel; Cohort Studies; Edema; Endarterectomy, Carotid; Female; Hemorrhage; Humans; International Normalized Ratio; Male; Middle Aged; Partial Thromboplastin Time; Platelet Aggregation Inhibitors; Postoperative Complications; Prothrombin Time; Retrospective Studies; Risk; Stroke; Ticlopidine | 2010 |
Duration of clopidogrel treatment and risk of mortality and recurrent myocardial infarction among 11 680 patients with myocardial infarction treated with percutaneous coronary intervention: a cohort study.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Denmark; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Registries; Retrospective Studies; Risk Factors; Secondary Prevention; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
HORIZONS-AMI.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Heparin; Hirudins; Humans; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Stents; Ticlopidine; Treatment Outcome | 2010 |
Long-term results of carotid artery stents to manage symptomatic carotid artery stenosis and factors that affect outcome.
Topics: Adult; Aged; Aged, 80 and over; Blood Vessel Prosthesis Implantation; Carotid Stenosis; Chemotherapy, Adjuvant; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Recurrence; Risk Assessment; Stents; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome; Vision Disorders | 2010 |
Safety and efficacy of clopidogrel treatment in Japanese patients undergoing drug-eluting stent implantation.
Topics: Aged; Clopidogrel; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2010 |
Omeprazole and clopidogrel: Should clinicians be worried?
Topics: Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Personalized medicine, pharmacogenetics, and clopidogrel: unraveling variability of response.
Topics: Clopidogrel; Humans; Individuality; Pharmacogenetics; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine | 2010 |
Efficacy of modified dual antiplatelet therapy combined with warfarin following percutaneous coronary intervention with drug-eluting stents.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Coronary Restenosis; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome; Warfarin | 2010 |
Lack of outcome benefit and clopidogrel "resistance." The TRITON trial challenge.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Approval; Drug Resistance; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Stroke; Survival Analysis; Thiophenes; Ticlopidine; Treatment Outcome | 2010 |
Very late drug-eluting stent thrombosis in the perioperative period of endoscopic choledocholithotomy.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug-Eluting Stents; Endoscopy, Digestive System; Gallstones; Humans; Male; Middle Aged; Perioperative Care; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2009 |
High residual platelet reactivity after clopidogrel: extent of coronary atherosclerosis and periprocedural myocardial infarction in patients with stable angina undergoing percutaneous coronary intervention.
Topics: Aged; Angina Pectoris; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Severity of Illness Index; Stents; Ticlopidine; Treatment Outcome | 2010 |
Relationship between platelet reactivity inhibition and non-CABG related major bleeding in patients undergoing percutaneous coronary intervention.
Topics: Aged; Cardiovascular Surgical Procedures; Clopidogrel; Coronary Vessels; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.
Topics: 1-Naphthylisothiocyanate; Animals; Antibodies, Monoclonal; Biomarkers; Blood Coagulation; Blood Platelets; Cholestasis, Intrahepatic; Clopidogrel; Gene Expression; Hepatocytes; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Thromboplastin; Ticlopidine | 2010 |
Adrenergic receptor polymorphisms and platelet reactivity after treatment with dual antiplatelet therapy with aspirin and clopidogrel in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aspirin; Cell Adhesion Molecules; Chi-Square Distribution; Clopidogrel; Drug Therapy, Combination; Female; Gene Frequency; Genotype; Humans; Linear Models; Male; Microfilament Proteins; Middle Aged; Phenotype; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Prospective Studies; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-2; Ticlopidine; Treatment Outcome | 2010 |
In vitro effects of recombinant activated factor VIIa (NovoSeven) on clopidogrel-induced platelet inhibition.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Coagulants; Collagen; Coronary Artery Disease; Factor VIIa; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Recombinant Proteins; Thrombin; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Lack of complications in skin surgery of patients receiving clopidogrel as compared with patients taking aspirin, warfarin, and controls.
Topics: Aged; Anticoagulants; Aspirin; Case-Control Studies; Clopidogrel; Dermatologic Surgical Procedures; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Erythema; Female; Follow-Up Studies; Hematoma; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Surgical Wound Dehiscence; Surgical Wound Infection; Ticlopidine; Warfarin | 2010 |
Clopidogrel response: head-to-head comparison of different platelet assays to identify clopidogrel non responder patients after coronary stenting.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Humans; Linear Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2010 |
Triple therapy: the future or from the past?
Topics: Administration, Oral; Anticoagulants; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Myocardial Revascularization; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prognosis; Risk Factors; Stents; Thromboembolism; Ticlopidine | 2010 |
[Ticagrelor versus clopidogrel in patients with acute coronary syndromes: results of the PLATO study].
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Dose-Response Relationship, Drug; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Serum thromboxane B2 compared to five other platelet function tests for the evaluation of aspirin effect in stable cardiovascular disease.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Pressure; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Female; Fish Oils; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Statistics as Topic; Statistics, Nonparametric; Surveys and Questionnaires; Thromboxane B2; Ticlopidine | 2010 |
Safety of drug eluting stents in patients on chronic anticoagulation using long-term single antiplatelet treatment with clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
VerifyNow and VASP phosphorylation assays give similar results for patients receiving clopidogrel, but they do not always correlate with platelet aggregation.
Topics: Adult; Aged; Aged, 80 and over; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Thrombosis; Ticlopidine | 2010 |
Inhibitory effects of ticlopidine and clopidogrel on the intimal hyperplastic response after arterial injury.
Topics: Angioplasty, Balloon; Animals; Clopidogrel; Fibroblast Growth Factors; Hyperplasia; Iliac Artery; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; Rabbits; Ticlopidine; Tunica Intima | 2010 |
Antiplatelet therapy with clopidogrel or ticlopidine reduces intimal hyperplasia in an animal model of experimental arterial injury.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Animals; Arteries; Cell Division; Clopidogrel; Coronary Artery Bypass; Disease Models, Animal; Humans; Muscle, Smooth, Vascular; Myocardial Infarction; Platelet Aggregation Inhibitors; Rabbits; Ticlopidine | 2010 |
The impact of treatment with omeprazole on the effectiveness of clopidogrel drug therapy during the first year after successful coronary stenting.
Topics: Administration, Oral; Angina, Unstable; Angioplasty, Balloon, Coronary; Cause of Death; Clopidogrel; Drug Therapy, Combination; Enzyme Inhibitors; Female; Follow-Up Studies; Greece; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Omeprazole; Patient Readmission; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
[Perioperative management of patients with coronary stents in non-cardiac surgery].
Topics: Aspirin; Clopidogrel; Coronary Vessels; Drug-Eluting Stents; Elective Surgical Procedures; Guidelines as Topic; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Risk Assessment; Stents; Surgical Procedures, Operative; Thrombosis; Ticlopidine | 2010 |
[Risky to combine clopidogrel with proton pump inhibitor?].
Topics: Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Information Services; Drug Interactions; Enzyme Inhibitors; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2009 |
Triple antiplatelet therapy reduces ischemic events after drug-eluting stent implantation: Drug-Eluting stenting followed by Cilostazol treatment REduces Adverse Serious cardiac Events (DECREASE registry).
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Tetrazoles; Thrombosis; Ticlopidine; Time Factors | 2010 |
Triple therapy: triple safety or triple danger?
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug Tolerance; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Stents; Thromboembolism; Ticlopidine; Treatment Outcome | 2010 |
Variability of residual platelet function despite clopidogrel treatment in patients with peripheral arterial occlusive disease.
Topics: Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Patient Compliance; Peripheral Vascular Diseases; Platelet Aggregation; Ticlopidine | 2010 |
[Non-occlusive stent thrombosis associated to cardiocirculatory arrest].
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Drug-Eluting Stents; Electroencephalography; Female; Heart Arrest; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Oral anticoagulation with coumarin derivatives and antiplatelet effects of clopidogrel.
Topics: Adenosine Diphosphate; Administration, Oral; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Artery Disease; Cross-Sectional Studies; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multivariate Analysis; Phenprocoumon; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Antiplatelet therapy after percutaneous coronary intervention: Should another regimen be "TAPT?".
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Chemotherapy, Adjuvant; Cilostazol; Clinical Trials as Topic; Clopidogrel; Contraindications; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Tetrazoles; Thrombosis; Ticlopidine | 2010 |
Multivariate-adjusted pharmacoepidemiologic analyses of confidential information pooled from multiple health care utilization databases.
Topics: Anti-Ulcer Agents; Clopidogrel; Confidentiality; Databases, Factual; Female; Humans; Male; Meta-Analysis as Topic; Multivariate Analysis; Myocardial Infarction; Pharmacoepidemiology; Platelet Aggregation Inhibitors; Privacy; Product Surveillance, Postmarketing; Propensity Score; Proton Pump Inhibitors; Risk Factors; Ticlopidine; Treatment Outcome; Utilization Review | 2010 |
Clopidogrel-induced acute generalized exanthematous pustulosis with elevated Th17 cytokine levels as determined by a drug lymphocyte stimulation test.
Topics: Acute Disease; Acute Generalized Exanthematous Pustulosis; Aged; Clopidogrel; Humans; Interleukin-17; Lymphocyte Activation; Male; Platelet Aggregation Inhibitors; Th17 Cells; Ticlopidine | 2010 |
The dental implant patient on anticoagulant therapy.
Topics: Anticoagulants; Aspirin; Clopidogrel; Dental Care for Chronically Ill; Dental Implantation, Endosseous; Heparin; Ticlopidine; Warfarin | 2010 |
Long-term effectiveness and safety of sirolimus stent implantation for coronary in-stent restenosis results of the TRUE (Tuscany Registry of sirolimus for unselected in-stent restenosis) registry at 4 years.
Topics: Aged; Aged, 80 and over; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Creatinine; Diabetes Mellitus; Drug-Eluting Stents; Follow-Up Studies; Humans; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Sirolimus; Stroke Volume; Ticlopidine | 2010 |
Slow response to clopidogrel predicts low response.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Biomarkers, Pharmacological; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
Inconsistent trial assessments by the National Institute for Health and Clinical Excellence and IQWiG: standards for the performance and interpretation of subgroup analyses are needed.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; England; Evidence-Based Medicine; Germany; Humans; Intention to Treat Analysis; Randomized Controlled Trials as Topic; Research Design; Ticlopidine | 2010 |
Impact of high-responsiveness to dual antiplatelet therapy on bleeding complications in patients receiving drug-eluting stents.
Topics: Aged; Angioplasty, Balloon, Laser-Assisted; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Pyridines; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2010 |
Antithrombotic effects of Danggui, Honghua and potential drug interaction with clopidogrel.
Topics: Animals; Bleeding Time; Carthamus tinctorius; Clopidogrel; Drug Interactions; Drugs, Chinese Herbal; Male; Pulmonary Embolism; Rats; Rats, Sprague-Dawley; Risk Factors; Thrombosis; Ticlopidine; Venous Thrombosis | 2010 |
[Cardiac workup after cerebral ischemia. Consensus paper of the Working Group on Heart and Brain of the German Cardiac Society and German Stroke Society].
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Echocardiography; Electrocardiography, Ambulatory; Embolism; Exercise Test; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Warfarin | 2010 |
Antiplatelet therapy: cangrelor for ACS-lessons from the CHAMPION trials.
Topics: Acute Coronary Syndrome; Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
Epidural analgesia in vascular surgery patients actively taking clopidogrel.
Topics: Aged; Analgesia, Epidural; Clopidogrel; Female; Hematoma, Epidural, Spinal; Humans; Male; Middle Aged; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Ticlopidine; Vascular Surgical Procedures | 2010 |
Positional brain ischemia with MCA occlusion successfully treated with extra-intracranial bypass.
Topics: Aspirin; Cerebral Revascularization; Clopidogrel; Humans; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Middle Aged; Middle Cerebral Artery; Paresis; Parietal Lobe; Platelet Aggregation Inhibitors; Posture; Temporal Arteries; Thrombophilia; Ticlopidine; Tomography, Emission-Computed, Single-Photon | 2010 |
Antithrombotic activity of F 16618, a new PAR1 antagonist evaluated in extracorporeal arterio-venous shunt in the rat.
Topics: Animals; Arterial Occlusive Diseases; Arteriovenous Shunt, Surgical; Aspirin; Bleeding Time; Clopidogrel; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; Male; Piperazines; Platelet Aggregation; Pyridines; Rats; Receptor, PAR-1; Thrombosis; Ticlopidine | 2010 |
Role of ticagrelor in clopidogrel nonresponders: resistance is futile?
Topics: Adenosine; Clopidogrel; Coronary Artery Disease; Drug Resistance; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticagrelor; Ticlopidine | 2010 |
Fecal occult blood test in patients on low-dose aspirin, warfarin, clopidogrel, or non-steroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Colonic Neoplasms; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; Logistic Models; Male; Mass Screening; Middle Aged; Occult Blood; Odds Ratio; Platelet Aggregation Inhibitors; Predictive Value of Tests; Retrospective Studies; Ticlopidine; Unnecessary Procedures; Warfarin | 2010 |
ATP induced microglial cell migration through non-transcriptional activation of matrix metalloproteinase-9.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Cell Movement; Cells, Cultured; Clopidogrel; Dipeptides; Dose-Response Relationship, Drug; Heterocyclic Compounds, 1-Ring; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Microglia; Phosphoinositide-3 Kinase Inhibitors; Protein Processing, Post-Translational; Purinergic P2 Receptor Antagonists; Rats; Sulfones; Ticlopidine; Wortmannin | 2010 |
Impact of persistence with antiplatelet therapy on recurrent ischemic stroke and predictors of nonpersistence among ischemic stroke survivors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Female; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Stroke; Survivors; Ticlopidine; Treatment Outcome; Young Adult | 2010 |
[Antiplatelet treatment after percutaneous coronary intervention in a patient with idiopathic thrombocytopenic purpura].
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Humans; Male; Platelet Aggregation Inhibitors; Purpura, Thrombocytopenic, Idiopathic; Ticlopidine; Treatment Outcome | 2009 |
Evaluation of antiplatelet effects of a modified protocol by platelet aggregation in patients undergoing "one-stop" hybrid coronary revascularization.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Ticlopidine | 2010 |
[Spontaneous haematoma of the psoas muscle with femoral neuropathy associated with antiplatelet treatment with clopidogrel: Is surgical decompression indicated?].
Topics: Clopidogrel; Decompression, Surgical; Female; Femoral Neuropathy; Hematoma; Humans; Middle Aged; Platelet Aggregation Inhibitors; Psoas Muscles; Ticlopidine | 2010 |
Comparison of different antithrombotic regimens for patients with atrial fibrillation undergoing drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Fibrinolytic Agents; Follow-Up Studies; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Prospective Studies; Risk Factors; Stroke; Thromboembolism; Ticlopidine; Treatment Outcome; Warfarin | 2010 |
Clinical relevance of clopidogrel unresponsiveness during elective coronary stenting: experience with the point-of-care platelet function assay-100 C/ADP.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Vessels; Death, Sudden, Cardiac; Drug Resistance; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Preoperative Care; Prospective Studies; Risk Factors; Stents; Thrombosis; Ticlopidine; Time Factors | 2010 |
Clopidogrel use and clinical events after drug-eluting stent implantation: findings from the HealthCore Integrated Research Database.
Topics: Aged; Clopidogrel; Cohort Studies; Databases, Factual; Drug Administration Schedule; Drug-Eluting Stents; Female; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Mortality; Myocardial Infarction; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Retrospective Studies; Ticlopidine | 2010 |
Relation of proton pump inhibitor use after percutaneous coronary intervention with drug-eluting stents to outcomes.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Survival Rate; Ticlopidine | 2010 |
Letter by Doraiswamy regarding article, "Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention: results from the double-blind, prospective, randomized Tailoring
Topics: Anticoagulants; Aspirin; Clopidogrel; Confounding Factors, Epidemiologic; Double-Blind Method; Drug Resistance; Elective Surgical Procedures; Hemorrhage; Heparin; Humans; Myocardial Revascularization; Patient Selection; Platelet Aggregation Inhibitors; Postoperative Complications; Randomized Controlled Trials as Topic; Research Design; Thromboembolism; Ticlopidine; Tirofiban; Tyrosine | 2010 |
Cost-effectiveness analysis of short-term clopidogrel therapy for ST elevation myocardial infarction.
Topics: Adolescent; Adult; Aged; Clopidogrel; Cost-Benefit Analysis; Diagnosis-Related Groups; Female; Hospital Costs; Humans; Male; Medicare; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Thrombolytic Therapy; Ticlopidine; United States | 2010 |
Acute myocardial infarction related to very late sirolimus-eluting stent thrombosis 6 months after discontinuation of dual antiplatelet therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Prosthesis Design; Sirolimus; Ticlopidine; Time Factors | 2011 |
DMET microarray technology for pharmacogenomics-based personalized medicine.
Topics: Carrier Proteins; Clopidogrel; Cytochrome P-450 Enzyme System; DNA; Enzymes; Equipment Reuse; Gene Frequency; Genome; Humans; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Pharmaceutical Preparations; Pharmacogenetics; Polymerase Chain Reaction; Precision Medicine; Staining and Labeling; Ticlopidine; Warfarin | 2010 |
Trial watch. DAPT study.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Multicenter Studies as Topic; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2010 |
[Evaluating the biological efficacy of clopidogrel: genotype or phenotype?].
Topics: Administration, Oral; Aryl Hydrocarbon Hydroxylases; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Microfilament Proteins; Phenotype; Phosphoproteins; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2010 |
[Comment about patients with dual antiplatelet therapy].
Topics: Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Contraindications; Drug Therapy, Combination; Elective Surgical Procedures; Humans; Myocardial Revascularization; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Preoperative Care; Thromboembolism; Ticlopidine | 2010 |
Impact of chronic kidney disease on platelet function profiles in diabetes mellitus patients with coronary artery disease taking dual antiplatelet therapy.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cross-Sectional Studies; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Treatment Outcome | 2010 |
The loading dose of clopidogrel in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon; Aspirin; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Preinterventional clopidogrel response variability for coil embolization of intracranial aneurysms: clinical implications.
Topics: Aged; Blood Coagulation Tests; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Intracranial Thrombosis; Logistic Models; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Risk Factors; Sensitivity and Specificity; Ticlopidine | 2010 |
Long-term aspirin and clopidogrel response evaluated by light transmission aggregometry, VerifyNow, and thrombelastography in patients undergoing percutaneous coronary intervention.
Topics: Adult; Aspirin; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombelastography; Ticlopidine | 2010 |
Postpolypectomy bleeding in patients undergoing colonoscopy on uninterrupted clopidogrel therapy.
Topics: Aged; Clopidogrel; Colonic Polyps; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; Logistic Models; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Factors; Ticlopidine | 2010 |
Changes in platelets and anticoagulant protein activity during adenosine-exercise single-photon emission computed tomography stress test.
Topics: Adenosine; Adenosine Diphosphate; Adult; Aged; Antithrombins; Aspirin; beta-Thromboglobulin; Blood Coagulation; Clopidogrel; Coronary Stenosis; Epinephrine; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Perfusion Imaging; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 4; Protein C; Ticlopidine; Tomography, Emission-Computed, Single-Photon; Vasodilator Agents | 2010 |
Combination of clopidogrel and everolimus dramatically reduced the development of transplant arteriosclerosis in murine aortic allografts.
Topics: Animals; Aorta, Abdominal; Arteriosclerosis; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Everolimus; Graft Rejection; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Platelet Aggregation; Platelet Aggregation Inhibitors; Sirolimus; Ticlopidine; Transplantation, Homologous; Treatment Outcome | 2010 |
Optimal duration of clopidogrel use after implantation of drug-eluting stents--still in doubt.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2010 |
Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study.
Topics: Adult; Aged; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2010 |
Propensity score adjustment with multilevel data: setting your sites on decreasing selection bias.
Topics: Cardiovascular Diseases; Clopidogrel; Data Interpretation, Statistical; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Proton Pump Inhibitors; Selection Bias; Ticlopidine | 2010 |
Delays of event adjudication in the TRITON trial.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Cerebral Infarction; Clopidogrel; Coronary Restenosis; Data Collection; Disease-Free Survival; Hemorrhage; Myocardial Infarction; Observer Variation; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Reproducibility of Results; Research Design; Stents; Thiophenes; Ticlopidine; Treatment Outcome; United States; United States Food and Drug Administration | 2010 |
Recurrence of acute myocardial infarction in patients discharged on clopidogrel and a proton pump inhibitor after stent placement for acute myocardial infarction.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Angioplasty, Balloon, Coronary; Anti-Ulcer Agents; Clopidogrel; Confidence Intervals; Drug Therapy, Combination; Esomeprazole; Female; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Pantoprazole; Patient Readmission; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Treatment Failure | 2010 |
Platelet inhibition with cangrelor.
Topics: Adenosine Monophosphate; Administration, Oral; Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Infusions, Intravenous; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2010 |
Stability of an extemporaneously prepared clopidogrel oral suspension.
Topics: Chromatography, High Pressure Liquid; Clopidogrel; Drug Compounding; Drug Contamination; Drug Stability; Drug Storage; Excipients; Pharmacy Service, Hospital; Platelet Aggregation Inhibitors; Reference Standards; Suspensions; Sweetening Agents; Tablets; Taste; Ticlopidine | 2010 |
Point-of-care assessment of platelet reactivity after clopidogrel to predict myonecrosis in patients undergoing percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; Blood Platelets; Clopidogrel; Coronary Artery Disease; Creatine Kinase, MB Form; Female; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Troponin I | 2010 |
[Multicentric study of thrombosis prevention in upper-extremity microsurgery. Survey at the Fesum centers].
Topics: Aspirin; Clopidogrel; Drug Monitoring; Evidence-Based Practice; Fibrinolytic Agents; France; Hemorrhage; Heparin; Humans; Microsurgery; Perioperative Care; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Pyrrolidines; Research Design; Risk Factors; Skin Transplantation; Surgical Flaps; Thrombosis; Ticlopidine; Upper Extremity | 2010 |
Preliminary evidence of a high risk of bleeding on aspirin plus clopidogrel in aspirin-naïve patients in the acute phase after TIA or minor ischaemic stroke.
Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Incidence; Ischemic Attack, Transient; Longitudinal Studies; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stroke; Ticlopidine | 2010 |
Platelet inhibition with cangrelor.
Topics: Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation Inhibitors; Research Design; Ticlopidine | 2010 |
Time matters for reducing risk of stroke.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Ischemic Attack, Transient; Risk; Stroke; Ticlopidine | 2010 |
Increased mortality associated with low use of clopidogrel in patients with heart failure and acute myocardial infarction not undergoing percutaneous coronary intervention: a nationwide study.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Denmark; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Survival Analysis; Ticlopidine | 2010 |
Clopidogrel and heart failure survival: missed opportunity or wrong turn?
Topics: Clopidogrel; Denmark; Heart Failure; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Antiplatelet drugs and risk of subarachnoid hemorrhage: a population-based case-control study.
Topics: Adolescent; Adult; Aged; Aspirin; Case-Control Studies; Clopidogrel; Denmark; Dipyridamole; Female; Humans; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Registries; Risk; Subarachnoid Hemorrhage; Ticlopidine; Time Factors; Young Adult | 2010 |
Clopidogrel and proton pump inhibitors: can near patient testing help in the tailoring of dual antiplatelet prescription?
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Usefulness of clopidogrel to protect against diabetes-induced vascular damage.
Topics: Adult; Aged; Cell Count; Clopidogrel; Diabetes Complications; Diabetes Mellitus, Type 2; Endothelial Cells; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Diseases | 2010 |
Optimal dual antiplatelet treatment after drug-eluting stent implantation: it's not the time for weaning.
Topics: Clopidogrel; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prosthesis Implantation; Thrombosis; Ticlopidine | 2010 |
Capillary zone electrophoresis method for determination of (+)-S clopidogrel carboxylic acid metabolite in human plasma and urine designed for biopharmaceutic studies.
Topics: Carboxylic Acids; Clopidogrel; Electrophoresis, Capillary; Humans; Limit of Detection; Reproducibility of Results; Ticlopidine | 2010 |
[13C]pantoprazole breath test as a predictor of the anti-platelet function of clopidogrel.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers, Pharmacological; Breath Tests; Carbon Isotopes; Clopidogrel; Cytochrome P-450 CYP2C19; Feasibility Studies; Female; Genotype; Humans; Male; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Effects of clopidogrel on vascular proliferation and apoptosis in an atherosclerotic rabbit model.
Topics: Animals; Apoptosis; Atherosclerosis; Atorvastatin; C-Reactive Protein; Catheterization; Clopidogrel; Endothelium, Vascular; Heptanoic Acids; Inflammation; Male; Platelet-Derived Growth Factor; Pyrroles; Rabbits; Random Allocation; Ticlopidine; Tunica Intima | 2010 |
The use of amlodipine, but not of P-glycoprotein inhibiting calcium channel blockers is associated with clopidogrel poor-response.
Topics: Aged; Amlodipine; Angioplasty; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Calcium Channel Blockers; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Ticlopidine | 2010 |
Acute coronary syndrome and severe haemophilia: an unusual association with challenging treatment.
Topics: Acute Coronary Syndrome; Anticoagulants; Clopidogrel; Coagulants; Comorbidity; Coronary Angiography; Dyspnea; Factor VIII; Fatal Outcome; Hemophilia A; Heparin, Low-Molecular-Weight; Humans; Hypertension; Male; Middle Aged; Myocardial Infarction; Practice Guidelines as Topic; Renal Insufficiency; Ticlopidine | 2010 |
Adverse events after stopping clopidogrel in post-acute coronary syndrome patients: Insights from a large integrated healthcare delivery system.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Clopidogrel; Delivery of Health Care, Integrated; Female; Humans; Male; Middle Aged; Myocardial Infarction; Patient Discharge; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Survival Analysis; Ticlopidine; United States; Withholding Treatment | 2010 |
Evidence for interaction between clopidogrel and proton-pump inhibitors.
Topics: Clopidogrel; Controlled Clinical Trials as Topic; Drug Interactions; Humans; Omeprazole; Platelet Aggregation Inhibitors; Platelet Count; Proton Pump Inhibitors; Ticlopidine; United States; United States Food and Drug Administration | 2010 |
Prasugrel, Māori, and personalised medicine in New Zealand.
Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Markers; Genetic Testing; Humans; Native Hawaiian or Other Pacific Islander; Pharmacogenetics; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Precision Medicine; Stents; Thiophenes; Thrombosis; Ticlopidine; Vascular Diseases | 2010 |
Safety of concomitant use of proton pump inhibitors and clopidogrel.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Proton Pump Inhibitors; Ticlopidine | 2010 |
Is it naive to load only clopidogrel-naive patients prior to PCI?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Myocardial Ischemia; Myocardial Revascularization; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Early and intermediate outcomes of left main coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Coronary Vessels; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Survival; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography; Ventricular Function, Left | 2010 |
If I take the blood thinner Plavix, should I avoid using Prilosec or other heartburn medications?
Topics: Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Health Knowledge, Attitudes, Practice; Heartburn; Humans; Myocardial Infarction; Omeprazole; Patient Education as Topic; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine | 2010 |
Lateral medullary ischemia presenting with persistent hiccups and vertigo.
Topics: Administration, Oral; Aged; Angiography; Anticoagulants; Brain Ischemia; Clopidogrel; Head Movements; Heparin; Hiccup; Humans; Injections, Intravenous; Magnetic Resonance Imaging; Male; Medulla Oblongata; Nystagmus, Pathologic; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Vertigo | 2010 |
Non-invasive coronary flow reserve after successful primary angioplasty for acute anterior myocardial infarction is an independent predictor of left ventricular adverse remodelling.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Echocardiography; Female; Fractional Flow Reserve, Myocardial; Heart Ventricles; Hemodynamics; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Risk Assessment; ROC Curve; Sensitivity and Specificity; Statistics as Topic; Stroke Volume; Ticlopidine; Ventricular Function, Left | 2010 |
Controversial warning on Plavix and stomach-protecting medications.
Topics: Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Drug Labeling; Health Knowledge, Attitudes, Practice; Humans; Omeprazole; Platelet Aggregation Inhibitors; Stomach Ulcer; Ticlopidine; United States; United States Food and Drug Administration | 2010 |
I had two stents put in during the past year, but I'm going to have a hip replacement soon. Are there any heart-related or stent related precautions my doctor and I should take before the surgery?
Topics: Angioplasty, Balloon, Coronary; Arthroplasty, Replacement, Hip; Aspirin; Clopidogrel; Drug-Eluting Stents; Health Knowledge, Attitudes, Practice; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Stents; Ticlopidine | 2009 |
Electrochemical study of the antiplatelet agent clopidogrel and its determination using differential pulse voltammetry in bulk form and pharmaceutical preparations with a glassy carbon electrode.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Clopidogrel; Dosage Forms; Electrochemistry; Electrodes; Hydrogen-Ion Concentration; Indicators and Reagents; Pharmaceutical Solutions; Platelet Aggregation Inhibitors; Spectrophotometry, Ultraviolet; Tablets; Ticlopidine | 2010 |
A comparison of the VerifyNow P2Y12 point-of-care device and light transmission aggregometry to monitor platelet function with prasugrel and clopidogrel: an integrated analysis.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Databases, Factual; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2010 |
[Balancing act in antithrombotic therapy. Between hemorrhage and embolism].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Disease; Coronary Restenosis; Drug Interactions; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Phenprocoumon; Proton Pump Inhibitors; Stents; Thromboembolism; Ticlopidine | 2010 |
Pharmacy cost sharing, antiplatelet therapy utilization, and health outcomes for patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Cost Sharing; Cost-Benefit Analysis; Female; Follow-Up Studies; Health Benefit Plans, Employee; Health Care Costs; Hospitalization; Humans; Male; Middle Aged; Outcome and Process Assessment, Health Care; Platelet Aggregation Inhibitors; Prescription Fees; Retrospective Studies; Stents; Ticlopidine; United States | 2010 |
Late common iliac artery stent thrombosis in a patient with terminal malignancy.
Topics: Aged; Angiography; Aspirin; Atherosclerosis; Carcinoma, Renal Cell; Clopidogrel; Humans; Iliac Artery; Kidney Neoplasms; Male; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2010 |
Comment on "variations in the pharmacological management of patients treated with carotid endarterectomy: a survey of European vascular surgeons".
Topics: Aspirin; Carotid Artery Diseases; Clopidogrel; Endarterectomy, Carotid; Europe; Humans; Incidence; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prognosis; Risk Factors; Secondary Prevention; Surveys and Questionnaires; Ticlopidine | 2010 |
[Clopidogrel treatment and elective non-cardiac surgery].
Topics: Aspirin; Clopidogrel; Elective Surgical Procedures; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine | 2010 |
Individualised assessment of response to clopidogrel in patients presenting with acute coronary syndromes: a role for short thrombelastography?
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Biomarkers; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Bypass; Drug Monitoring; England; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Stents; Thrombelastography; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Delays in filling clopidogrel prescription after hospital discharge and adverse outcomes after drug-eluting stent implantation: implications for transitions of care.
Topics: Cardiovascular Diseases; Chemotherapy, Adjuvant; Clopidogrel; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Medication Therapy Management; Myocardial Infarction; Patient Compliance; Patient Discharge; Platelet Aggregation Inhibitors; Postoperative Complications; Prescriptions; Prosthesis Implantation; Retrospective Studies; Risk Factors; Survival Analysis; Ticlopidine; United States | 2010 |
Dysfunction of a 21-mm aortic bioprosthesis treated with percutaneous implantation of a CoreValve prosthesis.
Topics: Aged, 80 and over; Aortic Valve; Aortic Valve Stenosis; Aspirin; Calcinosis; Clopidogrel; Combined Modality Therapy; Echocardiography; Echocardiography, Transesophageal; Female; Follow-Up Studies; Heart Valve Prosthesis Implantation; Humans; Platelet Aggregation Inhibitors; Prosthesis Failure; Risk Factors; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2013 |
Relationship between chronic obstructive pulmonary disease and in-hospital management and outcomes in patients with acute myocardial infarction.
Topics: Aged; Aspirin; Clopidogrel; Comorbidity; Female; Health Services Accessibility; Hospital Mortality; Humans; Male; Myocardial Infarction; Poland; Pulmonary Disease, Chronic Obstructive; Risk Management; Ticlopidine; Treatment Outcome | 2010 |
[Recurrent stent thrombosis in a patient with non-ST-segment elevation acute coronary syndrome].
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Resistance; Electrocardiography; Equipment Failure Analysis; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine | 2010 |
Simultaneous determination of clopidogrel and its carboxylic acid metabolite by capillary electrophoresis.
Topics: Carboxylic Acids; Clopidogrel; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Least-Squares Analysis; Reproducibility of Results; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Temperature; Ticlopidine | 2010 |
[Thrombosis of pharmacoactive coronary endoprothesis after stopping antiplatelet treatment].
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cholecystectomy, Laparoscopic; Cholecystolithiasis; Clopidogrel; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Treatment Outcome | 2010 |
Risk of rehospitalization for patients using clopidogrel with a proton pump inhibitor.
Topics: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Cohort Studies; Confidence Intervals; Coronary Restenosis; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Patient Readmission; Probability; Proportional Hazards Models; Proton Pump Inhibitors; Reference Values; Retrospective Studies; Risk Assessment; Sex Factors; Survival Rate; Ticlopidine | 2010 |
Usefulness of monitoring platelet function by multiple electrode aggregometry in primary coronary artery bypass surgery.
Topics: Aged; Anesthesia, General; Aspirin; Blood Transfusion; Blood Volume; Clopidogrel; Coronary Artery Bypass; Erythrocyte Transfusion; Female; Humans; Hydroxyethyl Starch Derivatives; Male; Middle Aged; Monitoring, Intraoperative; Plasma Substitutes; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Postoperative Care; Postoperative Hemorrhage; Preanesthetic Medication; Prospective Studies; ROC Curve; Ticlopidine; Treatment Outcome | 2011 |
Plasma sequestration: a good therapy to prevent the deleterious effect of clopidogrel when clopidogrel is used within one to four days of coronary bypass surgery.
Topics: Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Critical Care; Erythrocyte Transfusion; Humans; Length of Stay; Plasmapheresis; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Ticlopidine; Time Factors | 2010 |
Cardiorenal syndromes--recommendations from clinical practice guidelines: the cardiologist's view.
Topics: Acute Disease; Acute Kidney Injury; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Chronic Disease; Clopidogrel; Heart Failure; Humans; Kidney Failure, Chronic; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Renal Insufficiency; Shock, Cardiogenic; Stroke Volume; Syndrome; Ticlopidine | 2010 |
In brief: poor metabolizers of clopidogrel (plavix).
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Labeling; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prodrugs; Ticlopidine | 2010 |
Probing the occult: testing for blood in the stools.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Clopidogrel; Colonic Neoplasms; Colonoscopy; Gastrointestinal Hemorrhage; Humans; Mass Screening; Occult Blood; Platelet Aggregation Inhibitors; Predictive Value of Tests; Ticlopidine; Unnecessary Procedures; Warfarin | 2010 |
Antithrombotic management in patients undergoing coronary stent implantation requiring chronic oral anticoagulation: how to balance safety and efficacy?
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Thrombus too big for pharmacology alone?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Combined Modality Therapy; Coronary Thrombosis; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Radiography; Thrombectomy; Thrombolytic Therapy; Ticlopidine | 2010 |
Incidence, correlates, and clinical impact of nuisance bleeding after antiplatelet therapy for patients with drug-eluting stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Dual low response to acetylsalicylic acid and clopidogrel is associated with myonecrosis and stent thrombosis after coronary stent implantation.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardium; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2010 |
Role of triple antithrombotic therapy in patients with atrial fibrillation and coronary artery stents.
Topics: Algorithms; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Vessels; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Management; Stents; Ticlopidine; Warfarin | 2010 |
Clopidogrel pathway.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Metabolic Networks and Pathways; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Clopidogrel treatment in a patient with ticlopidine-induced hepatitis following percutaneous coronary stenting.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine | 2010 |
Increased risk of bleeding in patients on clopidogrel therapy after drug-eluting stents implantation: insights from the HMO Research Network-Stent Registry (HMORN-stent).
Topics: Aged; Clopidogrel; Comorbidity; Drug-Eluting Stents; Female; Follow-Up Studies; Health Maintenance Organizations; Humans; Male; Middle Aged; Myocardial Infarction; Postoperative Hemorrhage; Prosthesis Implantation; Registries; Risk Factors; Ticlopidine | 2010 |
[Interview with Prof. Franz-Joseph Krozingen: Interventional cardiology on the success course].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Cardiology; Clinical Trials as Topic; Clopidogrel; Emergencies; Fibrinolysis; Forecasting; Humans; Length of Stay; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Stents; Thiophenes; Ticlopidine; Time Factors | 2010 |
Gastric acid-reducing medications and clopidogrel: what are the latest FDA recommendations?
Topics: Anticoagulants; Clopidogrel; Drug Interactions; Endoscopy, Gastrointestinal; Female; Humans; Male; Omeprazole; Proton Pump Inhibitors; Safety Management; Thromboembolism; Ticlopidine; United States; United States Food and Drug Administration | 2010 |
Dual antiplatelet therapy prior to carotid endarterectomy reduces post-operative embolisation and thromboembolic events: post-operative transcranial Doppler monitoring is now unnecessary.
Topics: Aged; Angioscopy; Anticoagulants; Aspirin; Clopidogrel; Dextrans; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Fibrinolytic Agents; Humans; Male; Medical Audit; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Retrospective Studies; Thromboembolism; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2010 |
Synergistic effect of a factor Xa inhibitor, TAK-442, and antiplatelet agents on whole blood coagulation and arterial thrombosis in rats.
Topics: Animals; Aspirin; Blood Coagulation; Blood Coagulation Tests; Clopidogrel; Drug Synergism; Factor Xa Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Sulfones; Thrombosis; Ticlopidine | 2010 |
The Cone-and-Plate(let) analyzer is not suitable to monitor clopidogrel therapy: a comparison with the flowcytometric VASP assay and optical aggregometry.
Topics: Adult; Aged; Blood Platelets; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Cohort Studies; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Retinal Cone Photoreceptor Cells; Ticlopidine | 2010 |
PPI use in patients commenced on clopidogrel: a retrospective cross-sectional evaluation.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cohort Studies; Cross-Sectional Studies; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Northern Territory; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Tasmania; Ticlopidine; Young Adult | 2010 |
Rotablation in the drug eluting era: immediate and long-term results from a single center experience.
Topics: Aged; Angioplasty, Balloon, Coronary; Angioplasty, Balloon, Laser-Assisted; Aspirin; Atherectomy, Coronary; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Genotyping: one piece of the puzzle to personalize antiplatelet therapy.
Topics: Clopidogrel; Cytochrome P-450 Enzyme System; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
The case for routine genotyping in dual-antiplatelet therapy.
Topics: Clopidogrel; Coronary Disease; Cytochrome P-450 Enzyme System; Genotype; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Withdrawal of clopidogrel in active gastric bleeding.
Topics: Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Platelet Aggregation Inhibitors; Research Design; Ticlopidine | 2010 |
Clopidogrel poor metabolizers may need alternative to standard regimen.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Labeling; Genotype; Health Care Costs; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Prodrugs; Ticlopidine | 2010 |
Clinician-patient discord: exploring differences in perspectives for discontinuing clopidogrel.
Topics: Aged; Attitude of Health Personnel; Attitude to Health; Clopidogrel; Communication; Comorbidity; Drug-Eluting Stents; Female; Humans; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Patients; Physician-Patient Relations; Physicians; Platelet Aggregation Inhibitors; Qualitative Research; Thrombosis; Ticlopidine | 2011 |
Dual antiplatelet therapy and heparin "bridging" significantly increase the risk of bleeding complications after pacemaker or implantable cardioverter-defibrillator device implantation.
Topics: Aged; Aged, 80 and over; Aspirin; Case-Control Studies; Clopidogrel; Confidence Intervals; Defibrillators, Implantable; Drug Therapy, Combination; Female; Follow-Up Studies; Heparin; Humans; Length of Stay; Male; Middle Aged; Odds Ratio; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Hemorrhage; Prevalence; Reference Values; Retrospective Studies; Risk Assessment; Ticlopidine; Warfarin | 2010 |
Potentiation of clopidogrel active metabolite formation by rifampicin leads to greater P2Y12 receptor blockade and inhibition of platelet aggregation after clopidogrel.
Topics: Adenosine Diphosphate; Adult; Area Under Curve; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Synergism; Humans; Male; Middle Aged; Platelet Aggregation; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Rifampin; Ticlopidine | 2010 |
Isolated and interactive impact of common CYP2C19 genetic variants on the antiplatelet effect of chronic clopidogrel therapy.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Ticlopidine | 2010 |
Late and very late stent thrombosis after polymer-based sirolimus- or paclitaxel-eluting stent implantation in real-world clinical practice.
Topics: Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug-Eluting Stents; Humans; Paclitaxel; Platelet Aggregation Inhibitors; Polymers; Sirolimus; Ticlopidine | 2010 |
Comparison of the incidence of late stent thrombosis after implantation of different drug-eluting stents in the real world coronary heart disease patients: three-year follow-up results.
Topics: Aged; Aspirin; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2010 |
The use of clopidogrel (Plavix) in patients undergoing nonelective orthopaedic surgery.
Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Clopidogrel; Cohort Studies; Contraindications; Female; Humans; Male; Orthopedic Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Ticlopidine | 2010 |
Carotid angioplasty in asymptomatic patients undergoing CABG surgery.
Topics: Aged; Angioplasty, Balloon; Anticoagulants; Carotid Stenosis; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Endarterectomy, Carotid; Feasibility Studies; Female; Heparin; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Severity of Illness Index; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Doppler | 2010 |
Similarity of solid state structures of R- and S-isomers of clopidogrel hydrogensulphate salt.
Topics: Calorimetry, Differential Scanning; Clopidogrel; Crystallization; Hydrogen Bonding; Indicators and Reagents; Magnetic Resonance Spectroscopy; Optical Rotation; Platelet Aggregation Inhibitors; Solvents; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Ticlopidine; X-Ray Diffraction | 2010 |
Effect of 450-mg loading dose of clopidogrel on platelet function in Japanese patients undergoing coronary stent placement.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Asian People; Clopidogrel; Coronary Artery Disease; Female; Hemorrhage; Humans; Japan; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
[Switching from clopidogrel hydrogen sulfate to clopidogrel besylate. Impaired antiplatelet effect in patients with ischemic stroke].
Topics: Aged; Cerebral Infarction; Clopidogrel; Drug Resistance; Humans; Ischemic Attack, Transient; Male; Neurologic Examination; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship; Therapeutic Equivalency; Ticlopidine | 2010 |
Impact of inflammatory state and metabolic control on responsiveness to dual antiplatelet therapy in type 2 diabetics after PCI: prognostic relevance of residual platelet aggregability in diabetics undergoing coronary interventions.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Glucose; C-Reactive Protein; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Cytokines; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunoassay; Inflammation; Male; Pilot Projects; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2010 |
Six-month survival benefits associated with clinical guideline recommendations in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Drug Utilization; Evidence-Based Medicine; Guideline Adherence; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Myocardial Revascularization; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Survival Analysis; Ticlopidine; Young Adult | 2010 |
Low risk of rebound events after a short course of clopidogrel in acute TIA or minor stroke.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Longitudinal Studies; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Risk Assessment; Severity of Illness Index; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Ultra-performance LC MS/MS method for quantification of clopidogrel active metabolite.
Topics: Chromatography, High Pressure Liquid; Clopidogrel; Humans; Molecular Structure; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Ticlopidine | 2010 |
Efficiency of preoperative tranexamic Acid in coronary bypass surgery: an analysis correlated with preoperative clopidogrel use.
Topics: Aged; Antifibrinolytic Agents; Blood Transfusion; Clopidogrel; Confidence Intervals; Coronary Artery Bypass; Coronary Artery Disease; Female; Health Status Indicators; Humans; Length of Stay; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Patient Readmission; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preanesthetic Medication; Prospective Studies; Regression Analysis; Risk Factors; Statistics as Topic; Ticlopidine; Tranexamic Acid; Turkey | 2010 |
[Experience of treatment of patients with myocardial infarction without raise of ST segment on ECG of high risk of cardiocomplications by method of coronary angioplasty].
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Clopidogrel; Electrocardiography; Female; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2010 |
Clopidogrel and burns: platelet replacement therapy may not prevent postoperative bleeding.
Topics: Aged; Burns; Clopidogrel; Epinephrine; Hemostatics; Humans; Ischemic Attack, Transient; Male; Platelet Aggregation Inhibitors; Platelet Transfusion; Postoperative Care; Postoperative Hemorrhage; Preoperative Care; Thrombin; Ticlopidine; Treatment Outcome; Vasoconstrictor Agents | 2010 |
Risk of adverse outcomes in Taiwan associated with concomitant use of clopidogrel and proton pump inhibitors in patients who received percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Patient Readmission; Population Surveillance; Prognosis; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Survival Rate; Taiwan; Ticlopidine | 2010 |
Nonfatal aplastic anemia associated with clopidogrel.
Topics: Anemia, Aplastic; Clopidogrel; Coronary Vessels; Humans; Male; Middle Aged; Neutropenia; Pancytopenia; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2010 |
Clinical pharmacology: antiplatelet therapy during surgery.
Topics: Aspirin; Blood Loss, Surgical; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine | 2010 |
[Clopidogrel. Are our patients taking it adequately?].
Topics: Aged; Clopidogrel; Cross-Sectional Studies; Drug Interactions; Female; Humans; Male; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Antiplatelet therapy and percutaneous coronary intervention in patients with acute coronary syndrome and thrombocytopenia.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Melena; Middle Aged; Neoplasms; Patient Selection; Platelet Aggregation Inhibitors; Platelet Count; Platelet Transfusion; Risk Assessment; Stents; Thrombocytopenia; Ticlopidine; Treatment Outcome | 2010 |
The evidence base for platelet function testing in patients undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Atherectomy; Clopidogrel; Coronary Thrombosis; Coronary Vessels; Diagnostic Tests, Routine; Drug-Eluting Stents; Evidence-Based Medicine; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Practice Guidelines as Topic; Prosthesis Implantation; Ticlopidine | 2010 |
Routine platelet testing should not be performed on all patients undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Atherectomy; Blood Platelets; Clopidogrel; Diagnostic Tests, Routine; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Practice Guidelines as Topic; Precision Medicine; Reference Standards; Reference Values; Research Design; Thrombosis; Ticlopidine | 2010 |
The causes and outcomes of inadequate implementation of existing guidelines for antiplatelet treatment in patients with acute coronary syndrome: the experience from Taiwan Acute Coronary Syndrome Descriptive Registry (T-ACCORD Registry).
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization; Female; Guideline Adherence; Hospitals; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Odds Ratio; Outcome and Process Assessment, Health Care; Patient Discharge; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Prospective Studies; Registries; Risk Assessment; Risk Factors; Taiwan; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
[Standard therapy of acute coronary syndrome becomes easier. Dual platelet inhibition with only 1 tablet].
Topics: Acute Coronary Syndrome; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Combinations; Germany; Guideline Adherence; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
[Interview with Prof. Uwe Zeymer, Ludwgshaven Clinic. Infarct register reveals high "loss ratios" in treatment (interview by Sonja Bohm)].
Topics: Aspirin; Clopidogrel; Drug Administration Schedule; Drug Combinations; Follow-Up Studies; Germany; Guideline Adherence; Humans; Long-Term Care; Medication Adherence; Myocardial Infarction; Platelet Aggregation Inhibitors; Registries; Survival Rate; Ticlopidine | 2010 |
Early stent thrombosis with progressive brainstem infarction in a clopidogrel non-responder.
Topics: Aged; Brain Infarction; Brain Ischemia; Clopidogrel; Disease Progression; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2010 |
Pharmacogenetics testing: implications for cardiovascular therapeutics with clopidogrel and warfarin.
Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Labeling; Genetic Testing; Humans; Patient Selection; Pharmacogenetics; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Predictive Value of Tests; Ticlopidine; United States; United States Food and Drug Administration; Warfarin | 2010 |
Risk of hematoma complications after device implant in the clopidogrel era.
Topics: Aged; Aged, 80 and over; Anticoagulants; Cardiac Pacing, Artificial; Chi-Square Distribution; Clopidogrel; Defibrillators, Implantable; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electric Countershock; Female; Hematoma; Heparin; Humans; Length of Stay; Logistic Models; Male; Michigan; Odds Ratio; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Prospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
[A case of drug-induced pneumonia caused by clopidogrel].
Topics: Aged; Angina Pectoris; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Pneumonia; Ticlopidine | 2010 |
Clopidogrel and proton pump inhibitor (PPI) interaction: separate intake and a non-omeprazole PPI the solution?
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Ticlopidine | 2010 |
Iliac vein compression syndrome: an underdiagnosed cause of lower extremity deep venous thrombosis.
Topics: Anticoagulants; Clopidogrel; Constriction, Pathologic; Heparin; Humans; Iliac Vein; Lower Extremity; Male; Platelet Aggregation Inhibitors; Syndrome; Thrombectomy; Thrombolytic Therapy; Ticlopidine; Venous Thrombosis; Warfarin; Young Adult | 2010 |
Glycemic control and clopidogrel response.
Topics: Blood Glucose; Cardiovascular Diseases; Clopidogrel; Diabetes Mellitus; Glycated Hemoglobin; Glycemic Index; Humans; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine | 2010 |
[Clopidogrel and its salts: any clnical implication?].
Topics: Atracurium; Cardiovascular Diseases; Chloral Hydrate; Clinical Trials as Topic; Clopidogrel; Humans; Hypnotics and Sedatives; Nicotinic Agonists; Platelet Aggregation; Platelet Aggregation Inhibitors; Therapeutic Equivalency; Ticlopidine | 2010 |
Costs and consequences of clopidogrel versus aspirin for secondary prevention of ischaemic events in (high-risk) atherosclerotic patients in Sweden: a lifetime model based on the CAPRIE trial and high-risk CAPRIE subpopulations.
Topics: Aged; Aspirin; Atherosclerosis; Clopidogrel; Cost-Benefit Analysis; Female; Humans; Male; Markov Chains; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Secondary Prevention; Sweden; Ticlopidine | 2010 |
Thrombelastograph platelet mapping in a patient receiving antiplatelet therapy.
Topics: Aspirin; Blood Coagulation Disorders; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Humans; Liver Cirrhosis; Platelet Aggregation Inhibitors; Point-of-Care Systems; Thrombelastography; Ticlopidine | 2010 |
Responding to the clopidogrel warning by the US food and drug administration: real life is complicated.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Contraindications; Cytochrome P-450 CYP2C19; Drug Approval; Genotype; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Precision Medicine; Ticlopidine; United States | 2010 |
ACCF/AHA Clopidogrel clinical alert: approaches to the FDA "boxed warning": a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association.
Topics: American Heart Association; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Contraindications; Cytochrome P-450 CYP2C19; Drug Labeling; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Ticlopidine; United States | 2010 |
By the way, doctor. I take a fiber supplement, but have heard that I shouldn't be taking it at the same times as medication. How far apart should I take fiber and medicines such as Plavix and Crestor?
Topics: Clopidogrel; Dietary Fiber; Dietary Supplements; Drug Interactions; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Pyrimidines; Rosuvastatin Calcium; Sulfonamides; Ticlopidine | 2010 |
Role of dual antiplatelet therapy in symptomatic patients with established vascular disease: putting the CHARISMA trial into therapeutic perspective.
Topics: Aspirin; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Thrombosis; Ticlopidine; Time Factors; Vascular Diseases | 2010 |
Pharmacodynamic and pharmacokinetic evaluation of clopidogrel and the carboxylic acid metabolite SR 26334 in healthy dogs.
Topics: Adenosine Diphosphate; Animals; Blood Coagulation; Blood Platelets; Carboxylic Acids; Clopidogrel; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Ticlopidine | 2010 |
The H(2)-receptor antagonist ranitidine interferes with clopidogrel-mediated P2Y(12) inhibition in platelets.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Interactions; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Platelet Activation; Purinergic P2Y Receptor Antagonists; Ranitidine; Receptors, Purinergic P2Y12; Ticlopidine | 2010 |
Peptic disease: a confounding factor for proton pump inhibitor-clopidogrel interaction?
Topics: Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Histamine2-receptor antagonists are an alternative to proton pump inhibitor in patients receiving clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Histamine H2 Antagonists; Humans; Male; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Ticlopidine | 2010 |
Antithrombotic therapies in patients with heart failure: hypothesis formulation from a research database.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Databases, Factual; Female; Fibrinolytic Agents; Follow-Up Studies; Heart Failure; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Sex Factors; Ticlopidine; United Kingdom; Warfarin; Young Adult | 2010 |
[Managing myocardial infarct in general practice].
Topics: Acute Coronary Syndrome; Algorithms; Angina, Unstable; Anticoagulants; Atorvastatin; Blood Chemical Analysis; Chest Pain; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Education, Medical, Continuing; Electroencephalography; Family Practice; Heparin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Pyrroles; Risk Factors; Switzerland; Ticlopidine | 2010 |
Ad hoc percutaneous coronary intervention after in-laboratory high dose clopidogrel loading for clopidogrel-naive patients: safe for all?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
6 steps to safer use of triple therapy. Take care when combining aspirin, Plavix, and warfarin.
Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Health Knowledge, Attitudes, Practice; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2009 |
[Dental management of patients using anti agregant drugs: background, risks and clinical guidelines].
Topics: Atherosclerosis; Clopidogrel; Dentistry; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; Thrombosis; Ticlopidine; Tooth Extraction | 2009 |
Is TRAP-6 suitable as a positive control for platelet reactivity when assessing response to clopidogrel?
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Peptide Fragments; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2010 |
High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake.
Topics: Aspirin; Clopidogrel; Drug Interactions; Fibrinogen; Glasgow Coma Scale; Hemorrhage; Hemostatics; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombelastography; Ticlopidine; Treatment Outcome; Wounds and Injuries | 2010 |
Epidural analgesia in vascular surgery patients actively taking clopidogrel.
Topics: Analgesia, Epidural; Clopidogrel; Hematoma, Epidural, Spinal; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Guidelines as Topic; Ticlopidine; Vascular Surgical Procedures | 2010 |
Impact of P2Y12 inhibition by clopidogrel on cardiovascular mortality in unselected patients treated by percutaneous coronary angioplasty: a prospective registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; Blood Platelets; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug-Eluting Stents; Female; Flow Cytometry; France; Humans; Kaplan-Meier Estimate; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Registries; Risk Assessment; Risk Factors; ROC Curve; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Post-thienopyridine platelet response, cardiovascular outcomes, and personalized therapy: En attendant Godot.
Topics: Angioplasty, Balloon, Coronary; Biomarkers; Blood Platelets; Cardiovascular Diseases; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug-Eluting Stents; Flow Cytometry; Humans; Microfilament Proteins; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Precision Medicine; Predictive Value of Tests; Prosthesis Design; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Evaluation of platelet function and pharmacological platelet inhibition in patients with myeloproliferative disorders using multiple electrode aggregometry.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Austria; Case-Control Studies; Clopidogrel; Electrodes; Female; Humans; Linear Models; Male; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polycythemia Vera; Predictive Value of Tests; Reproducibility of Results; Thrombocythemia, Essential; Thrombosis; Ticlopidine; Treatment Outcome; Young Adult | 2010 |
Management of perioperative stent thrombosis in patients undergoing surgery.
Topics: Aged; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Coronary Thrombosis; Humans; Male; Perioperative Period; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2010 |
Platelet aggregation and its association with stent thrombosis and bleeding in clopidogrel-treated patients: initial evidence of a therapeutic window.
Topics: Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Hemorrhage; Humans; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors | 2010 |
Rapid change in prescribing behavior in hospitals participating in get with the guidelines-stroke after release of the management of atherothrombosis with clopidogrel in high-risk patients (MATCH) clinical trial results.
Topics: Aspirin; Brain Ischemia; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Prescriptions; Stroke; Ticlopidine; United States | 2010 |
Initial experience with an institutional bridging protocol for patients with recent coronary stent implantation requiring discontinuation of dual antiplatelet therapy resulting from urgent surgery.
Topics: Antithrombins; Aspirin; Blood Loss, Surgical; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Hirudins; Humans; Peptide Fragments; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Recombinant Proteins; Stents; Surgical Procedures, Operative; Ticlopidine; Time Factors | 2011 |
How long should we delay hip fracture surgery for elderly patients on clopidogrel?
Topics: Aged; Clopidogrel; Hip Fractures; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2011 |
Comparison of conventional aggregometry with VASP for monitoring P2Y12-specific platelet inhibition.
Topics: Adenosine Diphosphate; Angina Pectoris; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Flow Cytometry; Humans; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Receptors, Purinergic P2Y12; Ticlopidine | 2010 |
Letter by Aboyans et al regarding article, "Smoking, clopidogrel, and mortality in patients with established cardiovascular disease".
Topics: Cardiovascular Diseases; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Smoking; Ticlopidine | 2010 |
Epidural analgesia in vascular surgery patients actively taking clopidogrel.
Topics: Analgesia, Epidural; Clopidogrel; Hematoma, Epidural, Spinal; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine; Vascular Surgical Procedures | 2010 |
[Clopidogrel and proton pump inhibitors: foe or friend?].
Topics: Clopidogrel; Drug Interactions; Humans; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2010 |
Response variation in patients treated with clopidogrel.
Topics: Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Carriage of cytochrome 2C19 polymorphism is associated with risk of high post-treatment platelet reactivity on high maintenance-dose clopidogrel of 150 mg/day: results of the ACCEL-DOUBLE (Accelerated Platelet Inhibition by a Double Dose of Clopidogrel Ac
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chi-Square Distribution; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Resistance; Female; Gene Frequency; Genotype; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Registries; Republic of Korea; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2010 |
Clopidogrel and proton pump inhibitors: between a rock and a hard place.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Interactions; Humans; Prodrugs; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2010 |
Impact of proton pump inhibitors on the effectiveness of clopidogrel after coronary stent placement: the clopidogrel Medco outcomes study.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug Synergism; Drug Therapy, Combination; Female; Hospitalization; Humans; Male; Middle Aged; Proton Pump Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2010 |
[Perioperative use of antithrombotic agents: recommendations of the American College of Chest Physicians (ACCP) and the French Superior Health Authority (HAS)].
Topics: Anticoagulants; Atrial Fibrillation; Cardiac Surgical Procedures; Clopidogrel; Fibrinolytic Agents; France; Heart Valve Prosthesis Implantation; Heparin; Heparin, Low-Molecular-Weight; Humans; Platelet Aggregation Inhibitors; Risk Factors; Societies, Medical; Ticlopidine; United States | 2010 |
[Comparison of effects of prasugrel and clopidogrel in patients with acute coronary syndrome, subjected to percutaneous coronary intervention: TRITON-TIMI 38 trial].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Stroke; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
[The problems of antiaggregant therapy of patients with acute myocardial infarction. Experience with the use of clopidogrel].
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Drugs, Generic; Electrocardiography; Health Care Costs; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 2010 |
Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel.
Topics: Animals; Aspirin; Carotid Arteries; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Factor VIIa; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Rabbits; Recombinant Proteins; Regional Blood Flow; Thrombosis; Ticlopidine | 2010 |
Risk of drug-eluting stent thrombosis in patients receiving proton pump inhibitors.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Chi-Square Distribution; Clopidogrel; Comorbidity; Confounding Factors, Epidemiologic; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Female; Germany; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Duration of clopidogrel therapy with drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2010 |
Hand surgery on anticoagulated patients: a prospective study of 121 operations.
Topics: Anticoagulants; Aspirin; Clopidogrel; Hand; Hemostasis, Surgical; Humans; International Normalized Ratio; Perioperative Care; Postoperative Hemorrhage; Thrombosis; Ticlopidine; Tourniquets; Warfarin | 2010 |
Letter by Potter and Le Lorier regarding article, "Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome".
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Pyridines; Selection Bias; Ticlopidine | 2010 |
Recurrent acute stent thrombosis due to allergic reaction secondary to clopidogrel therapy.
Topics: Acute Disease; Adult; Clopidogrel; Coronary Thrombosis; Drug Hypersensitivity; Humans; Male; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine | 2011 |
In-laboratory high-dose clopidogrel loading: do we need a mirror of diamond for "Armida's garden"?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
Platelet response to clopidogrel and restenosis in patients treated predominantly with drug-eluting stents.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2010 |
Conservative treatment of spontaneous dissection of multiple coronary arteries.
Topics: Adult; Anti-Arrhythmia Agents; Anticoagulants; Aortic Dissection; Aspirin; Clopidogrel; Coronary Aneurysm; Drug Therapy, Combination; Enoxaparin; Female; Humans; Metoprolol; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Incidence and predictors of intracranial hemorrhage after minor head trauma in patients taking anticoagulant and antiplatelet medication.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Craniocerebral Trauma; Female; Glasgow Coma Scale; Humans; Incidence; Intracranial Hemorrhage, Traumatic; Male; Massachusetts; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Tomography, X-Ray Computed; Trauma Centers; Warfarin | 2011 |
Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model.
Topics: Adenosine; Animals; Bleeding Time; Blood Coagulation; Clopidogrel; Coronary Circulation; Coronary Thrombosis; Disease Models, Animal; Dogs; Drug Therapy, Combination; Echocardiography; Female; Fibrinolytic Agents; Laser-Doppler Flowmetry; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Recurrence; Thrombolytic Therapy; Ticagrelor; Ticlopidine; Time Factors; Tissue Plasminogen Activator | 2010 |
Is there really a relationship between the plasma concentration of the active metabolite of clopidogrel and the results of platelet function tests?
Topics: Administration, Oral; Adolescent; Adult; Angioplasty, Balloon, Coronary; Area Under Curve; Cell Adhesion Molecules; Clopidogrel; Humans; Male; Microfilament Proteins; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Regression Analysis; Ticlopidine | 2010 |
Do not adjust the platelet count in light transmittance aggregometry when predicting thrombotic events after percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Humans; Ischemia; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; ROC Curve; Thrombosis; Ticlopidine | 2010 |
Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism.
Topics: Acute Coronary Syndrome; Alleles; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Blood Proteins; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Monitoring, Physiologic; Phosphoproteins; Platelet Activation; Polymerase Chain Reaction; Polymorphism, Genetic; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2010 |
Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotypes.
Topics: Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Female; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Statistics as Topic; Ticlopidine; Young Adult | 2010 |
Rapid and sequential desensitization to both aspirin and clopidogrel.
Topics: Angioedema; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Humans; Middle Aged; Stents; Ticlopidine; Time Factors; Urticaria | 2010 |
Pattern of clopidogrel use in hospitalized patients receiving percutaneous coronary interventions.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Utilization; Electronic Health Records; Female; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Perioperative Period; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Retrospective Studies; Ticlopidine; United States | 2010 |
Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates LPS-induced systemic inflammation in a rat model.
Topics: Animals; Blotting, Western; Clopidogrel; HMGB1 Protein; Inflammation; Interleukin-6; Lipopolysaccharides; Liver; Lung; Male; Purinergic P2Y Receptor Antagonists; Rats; Rats, Wistar; Ticlopidine; Tumor Necrosis Factor-alpha | 2011 |
Comparison of platelet reactivity and periprocedural outcomes in patients with versus without diabetes mellitus and treated with clopidogrel and percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Case-Control Studies; Clopidogrel; Cohort Studies; Coronary Stenosis; Diabetes Complications; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2010 |
Pre-procedural platelet reactivity after clopidogrel loading in korean patients undergoing scheduled percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Mutation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Republic of Korea; Risk Factors; Ticlopidine; Treatment Outcome | 2010 |
[Registries of myocardial infarction in Germany. Consequences for drug therapy of patients with acute ST elevation myocardial infarction].
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angina, Unstable; Angioplasty, Balloon, Coronary; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Electrocardiography; Evidence-Based Medicine; Germany; Guideline Adherence; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Randomized Controlled Trials as Topic; Registries; Secondary Prevention; Survival Analysis; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2010 |
Antiplatelet effect of clopidogrel is reduced in patients treated with therapeutic hypothermia after cardiac arrest.
Topics: Acute Coronary Syndrome; Clopidogrel; Female; Heart Arrest; Humans; Hypothermia, Induced; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2010 |
Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery disease.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon; Aspirin; Blood Platelets; C-Reactive Protein; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Female; Humans; Inflammation; Male; Pilot Projects; Platelet Activation; Stents; Ticlopidine; Treatment Outcome | 2010 |
The influence of proton pump inhibitors on the antiplatelet potency of clopidogrel evaluated by 5 different platelet function tests.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Stents; Ticlopidine | 2010 |
Mid-term outcomes of patients with PCI prior to CABG in comparison to patients with primary CABG.
Topics: Aged; Angina, Unstable; Angioplasty, Balloon, Coronary; Case-Control Studies; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Epinephrine; Female; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Norepinephrine; Platelet Aggregation Inhibitors; Postoperative Care; Statistics, Nonparametric; Stents; Ticlopidine; Treatment Outcome | 2010 |
Letter by Serebruany regarding article, "Cost-effectiveness of prasugrel versus clopidogrel in patients with acute coronary syndromes and planned percutaneous coronary intervention: results from the Trial to Assess Improvement in Therapeutic Outcomes by O
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Cost-Benefit Analysis; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2010 |
Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro.
Topics: Aryl Hydrocarbon Hydroxylases; Atorvastatin; Clarithromycin; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Heptanoic Acids; Humans; In Vitro Techniques; Ketoconazole; Microsomes, Liver; Models, Molecular; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Pyrroles; Recombinant Proteins; Simvastatin; Substrate Specificity; Ticlopidine | 2010 |
Transcatheter closure of patent foramen ovale (PFO) in patients with paradoxical embolism: procedural and follow-up results after implantation of the Amplatzer®-occluder device.
Topics: Aspirin; Cardiac Catheterization; Clopidogrel; Echocardiography, Transesophageal; Embolism, Paradoxical; Female; Foramen Ovale, Patent; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Septal Occluder Device; Stroke; Surveys and Questionnaires; Thromboembolism; Ticlopidine | 2011 |
Cardiovascular and gastrointestinal outcomes in clopidogrel users on proton pump inhibitors: results of a large Dutch cohort study.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Clopidogrel; Databases, Factual; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Netherlands; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2010 |
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticlopidine | 2010 |
Response to antiplatelet treatment: from genes to outcome.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Pharmacogenetics; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prasugrel Hydrochloride; Stents; Thiophenes; Ticlopidine | 2010 |
Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine | 2010 |
General thoracic surgery is safe in patients taking clopidogrel (Plavix).
Topics: Adult; Aged; Aged, 80 and over; Alabama; Angioplasty, Balloon, Coronary; Blood Loss, Surgical; Case-Control Studies; Chi-Square Distribution; Clopidogrel; Female; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Propensity Score; Prospective Studies; Risk Assessment; Risk Factors; Stents; Thoracic Surgical Procedures; Ticlopidine; Treatment Outcome | 2010 |
Does black ethnicity influence the development of stent thrombosis in the drug-eluting stent era?
Topics: Aged; Black People; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Regression Analysis; Retrospective Studies; Risk Factors; Social Class; Thrombosis; Ticlopidine; Treatment Outcome; White People | 2010 |
Individual variability of response and non-response to acetyl salicylic acid after cardiac surgery.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Cardiac Surgical Procedures; Clopidogrel; Dipyrone; Female; Humans; Male; Middle Aged; Pain, Postoperative; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Ticlopidine; Treatment Outcome; Young Adult | 2010 |
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk.
Topics: Animals; Anticoagulants; Clopidogrel; Drug Combinations; Enoxaparin; Factor XI; Hemorrhage; Male; Mice; Mice, Inbred BALB C; Oligonucleotides, Antisense; Thrombosis; Ticlopidine | 2010 |
Platelet CD154 potentiates interferon-alpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus.
Topics: Animals; Autoantibodies; Blood Platelets; CD40 Ligand; Clopidogrel; Dendritic Cells; Disease Models, Animal; Humans; Interferon-alpha; Lupus Erythematosus, Systemic; Mice; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, IgG; Ticlopidine | 2010 |
Cardiovascular and gastrointestinal events of three antiplatelet therapies: clopidogrel, clopidogrel plus proton-pump inhibitors, and aspirin plus proton-pump inhibitors in patients with previous gastrointestinal bleeding.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Agents; Gastrointestinal Hemorrhage; Humans; Incidence; Male; Middle Aged; Peptic Ulcer; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Risk; Taiwan; Ticlopidine; Treatment Outcome | 2011 |
Atorvastatin for reduction of myocardial damage during angioplasty trials.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents; Atorvastatin; Clopidogrel; Evidence-Based Medicine; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Infarction; Myocardium; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine; Treatment Outcome | 2010 |
Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel .
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Crystallography, X-Ray; Cytochrome P450 Family 2; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Platelet Aggregation Inhibitors; Protein Binding; Rabbits; Ticlopidine | 2010 |
Acute coronary syndromes: finding meaning in OASIS 7.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2010 |
Fine-tuning therapy for acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Angiography; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Impact of platelet transfusion on hematoma expansion in patients receiving antiplatelet agents before intracerebral hemorrhage.
Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Databases, Factual; Female; Hematoma; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Retrospective Studies; Statistics, Nonparametric; Ticlopidine; Treatment Outcome | 2010 |
[Proton pump inhibitors and clopidogrel: what are we doing now?].
Topics: Clopidogrel; Contraindications; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Ticlopidine | 2010 |
[Diagnosis of peripheral arterial occlusive disease].
Topics: Algorithms; Angioplasty, Balloon; Arterial Occlusive Diseases; Aspirin; Blood Pressure Determination; Clopidogrel; Cross-Sectional Studies; Diagnosis, Differential; Diagnostic Imaging; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2010 |
Frequency and risk of noncardiac surgery after drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Chi-Square Distribution; Clopidogrel; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Risk Assessment; Risk Factors; Surgical Procedures, Operative; Texas; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Triple antiplatelet therapy reduces ischemic events after drug-eluting stent implantation: Drug-Eluting stenting followed by Cilostazol treatment REduces Adverse Serious cardiac Events (DECREASE registry).
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Registries; Stents; Tetrazoles; Thrombosis; Ticlopidine; Time Factors | 2010 |
Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events.
Topics: Aged; Alleles; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cardiovascular Diseases; Clopidogrel; Coronary Angiography; Coronary Restenosis; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Recurrence; Reoperation; Stents; Stroke; Ticlopidine | 2010 |
Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Risk Factors; ROC Curve; Stents; Ticlopidine | 2010 |
Lack of effect of chronic kidney disease on clopidogrel response with high loading and maintenance doses of clopidogrel after Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Insufficiency, Chronic; Ticlopidine | 2010 |
Duration of clopidogrel therapy with drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2010 |
Duration of clopidogrel therapy with drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Korea; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2010 |
Duration of clopidogrel therapy with drug-eluting stents.
Topics: Angioplasty, Balloon, Coronary; Asian People; Aspirin; Clopidogrel; Coronary Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Life Style; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2010 |
Acute and subacute stent thrombosis after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: incidence, predictors and clinical outcome.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Netherlands; Platelet Aggregation Inhibitors; Registries; Risk Factors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2010 |
CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Blood Vessel Prosthesis; Case-Control Studies; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Therapy, Combination; Female; Genotype; Graft Occlusion, Vascular; Heterozygote; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2010 |
Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation.
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Clopidogrel; Cohort Studies; Comorbidity; Denmark; Drug Therapy, Combination; Female; Hemorrhage; Humans; Incidence; Male; Proportional Hazards Models; Registries; Risk; Stroke; Ticlopidine; Warfarin | 2010 |
Conflicting evidence surrounding the clopidogrel and proton pump inhibitor drug interaction.
Topics: Clopidogrel; Coronary Restenosis; Drug Interactions; Drug Therapy, Combination; Humans; Myocardial Infarction; Patient Readmission; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Ticlopidine | 2010 |
Association between inflammatory biomarkers and platelet aggregation in patients under chronic clopidogrel treatment.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; C-Reactive Protein; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; Fibrinogen; Germany; Humans; Inflammation Mediators; Leukocyte Count; Linear Models; Logistic Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Effects of thienopyridines and thienopyrimidinones on L-type calcium current in isolated cardiomyocytes.
Topics: Action Potentials; Animals; Atrial Appendage; Calcium Channels, L-Type; Cells, Cultured; Clopidogrel; Guinea Pigs; Heart Ventricles; Humans; In Vitro Techniques; Myocytes, Cardiac; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Pyrimidines; Thienopyridines; Thiophenes; Ticlopidine | 2010 |
Epistaxis in patients taking oral anticoagulant and antiplatelet medication: prospective cohort study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Epistaxis; Hemostatic Techniques; Humans; International Normalized Ratio; Length of Stay; Middle Aged; Platelet Aggregation Inhibitors; Prevalence; Prospective Studies; Ticlopidine; Warfarin; Young Adult | 2011 |
Meperidine versus morphine, and PPIs with clopidogrel.
Topics: Analgesics, Opioid; Biliary Tract Diseases; Clopidogrel; Colic; Drug Interactions; Humans; Meperidine; Morphine; Pancreatitis; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Clopidogrel and endothelial injury after percutaneous coronary interventions: beyond the antiplatelet effects.
Topics: Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Endothelium, Vascular; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prosthesis Implantation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Ticlopidine; Vascular Diseases | 2010 |
Genetic variability in response to clopidogrel therapy: clinical implications.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Female; Graft Occlusion, Vascular; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study.
Topics: Adult; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug Interactions; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Recurrence; Regression Analysis; Risk Factors; Ticlopidine; Time Factors | 2010 |
Conflicting evidence: what's a clinician to do?
Topics: Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2010 |
An endovascular canine middle cerebral artery occlusion model for the study of leptomeningeal collateral recruitment.
Topics: Angiography; Animals; Anticoagulants; Brain Ischemia; Carotid Arteries; Clopidogrel; Disease Models, Animal; Dogs; Feasibility Studies; Heparin; Infarction, Middle Cerebral Artery; Middle Cerebral Artery; Multivariate Analysis; Platelet Aggregation Inhibitors; Statistics as Topic; Ticlopidine | 2011 |
[The PLATO study].
Topics: Acute Coronary Syndrome; Adenosine; Cardiovascular Diseases; Clopidogrel; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine | 2010 |
Clinical predictors of dual aspirin and clopidogrel poor responsiveness in stable cardiovascular patients from the ADRIE study.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2010 |
Does current oral antiplatelet agent or subtherapeutic anticoagulation use have an effect on tissue-plasminogen-activator-mediated recanalization rate in patients with acute ischemic stroke?
Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Retrospective Studies; Stroke; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator; Treatment Outcome; Warfarin | 2010 |
Recent research on antithrombotics. News on the treatment of patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Biomedical Research; Clopidogrel; Cyclic N-Oxides; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridines; Ticagrelor; Ticlopidine | 2010 |
Clopidogrel and cardiac operations.
Topics: Cardiac Surgical Procedures; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2010 |
Is clopidogrel premedication useful to reduce thromboembolic events during coil embolization for unruptured intracranial aneurysms?
Topics: Aneurysm, Ruptured; Clopidogrel; Embolization, Therapeutic; Female; Humans; Incidence; Intracranial Aneurysm; Intracranial Thrombosis; Korea; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Premedication; Prevalence; Risk Assessment; Risk Factors; Ticlopidine | 2010 |
[Clopidogrel resistance in patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; C-Reactive Protein; Clopidogrel; Drug Resistance; Electrocardiography; Female; Homozygote; Humans; Interleukin-10; Interleukin-6; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prognosis; Receptors, Purinergic P2Y12; Ticlopidine | 2010 |
Prasugrel as alternative treatment strategy in a case with a hypersensitivity reaction to clopidogrel.
Topics: Aged; Angioedema; Clopidogrel; Drug Hypersensitivity; Exanthema; Fever; Humans; Male; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Tachycardia; Thiophenes; Thrombosis; Ticlopidine | 2011 |
The new INNOVANCE® PFA P2Y cartridge is sensitive to the detection of the P2Y₁₂ receptor inhibition.
Topics: Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Biological Assay; Biomarkers; Blood Platelets; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Sensitivity and Specificity; Ticlopidine; Young Adult | 2011 |
Increased use of acid-suppressing drugs before the occurrence of ischemic events: a potential source of confounding in recent observational studies.
Topics: Adult; Aged; Angina, Unstable; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Confounding Factors, Epidemiologic; Drug Therapy, Combination; Epidemiologic Studies; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Research Design; Risk Factors; Ticlopidine; Time Factors | 2010 |
Use of genetics and transcriptomics in the diagnosis and treatment of coronary artery disease.
Topics: Anticoagulants; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Gene Expression Profiling; Genetic Testing; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2010 |
Intracoronary shear-related up-regulation of platelet P-selectin and platelet-monocyte aggregation despite the use of aspirin and clopidogrel.
Topics: Aged; Aspirin; Blood Platelets; CD11b Antigen; Clopidogrel; Coronary Artery Disease; Coronary Stenosis; Flow Cytometry; Humans; Leukocytes; Monocytes; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Up-Regulation | 2011 |
Efficacy and safety of bivalirudin in patients receiving clopidogrel therapy after diagnostic angiography for percutaneous coronary intervention in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Antithrombins; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Drug Administration Schedule; Drug Therapy, Combination; Female; Heart Diseases; Hemorrhage; Heparin; Hirudins; Hospital Mortality; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; New York City; Odds Ratio; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Propensity Score; Proportional Hazards Models; Recombinant Proteins; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
It is standard practice, but is it really best practice or clinical biocreep?
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Antithrombins; Clopidogrel; Coronary Angiography; Drug Administration Schedule; Drug Therapy, Combination; Heart Diseases; Hemorrhage; Heparin; Hirudins; Hospital Mortality; Humans; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Comparison of hemorrhagic complications of warfarin and clopidogrel bisulfate in 25-gauge vitrectomy versus a control group.
Topics: Aged; Anticoagulants; Cardiovascular Diseases; Choroid Hemorrhage; Clopidogrel; Humans; Incidence; Intraocular Pressure; Intraoperative Complications; Microsurgery; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Retinal Diseases; Retrobulbar Hemorrhage; Retrospective Studies; Risk Factors; Ticlopidine; Visual Acuity; Vitrectomy; Vitreous Hemorrhage; Warfarin | 2011 |
Outcomes related to antiplatelet or anticoagulation use in patients undergoing carotid endarterectomy.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Chi-Square Distribution; Clopidogrel; Endarterectomy, Carotid; Female; Hematoma; Humans; Male; Middle Aged; Minnesota; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2011 |
Determination of the prevalence of aspirin and clopidogrel resistances in patients with coronary artery disease by using various platelet-function tests.
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Tetrazoles; Ticlopidine | 2010 |
Assessing the risk of clopidogrel-related bleeding complications in patients undergoing inguinal herniorrhaphy.
Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Critical Care; Female; Hematoma; Hernia, Inguinal; Hospitalization; Humans; Male; Minor Surgical Procedures; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Retrospective Studies; Risk; Ticlopidine | 2011 |
Letter by Gurbel et al regarding article, "Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement".
Topics: Aryl Hydrocarbon Hydroxylases; Base Pairing; Chromosome Mapping; Clopidogrel; Cytochrome P-450 CYP2C19; Gene Frequency; Genetic Variation; Heterozygote; Homozygote; Humans; Linkage Disequilibrium; Platelet Aggregation; Stents; Ticlopidine | 2010 |
[Does dual antiplatelet therapy always require gastroprotection? Tailored medical therapy should prevail over the generalized prescription of proton pump inhibitors in patients on dual antiplatelet therapy].
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Electrocardiography; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Myocardial Infarction; Myocardial Revascularization; Odds Ratio; Peptic Ulcer; Platelet Aggregation Inhibitors; Prognosis; Proton Pump Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Ticlopidine; Time Factors | 2010 |
Cytochrome P450 2C19 polymorphism, suboptimal reperfusion and all-cause mortality in patients with acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Heterozygote; Homozygote; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prevalence; Risk Factors; Stents; Survival Analysis; Thrombosis; Ticlopidine | 2010 |
Incidence of hemorrhagic complications after intravitreal bevacizumab (avastin) or ranibizumab (lucentis) injections on systemically anticoagulated patients.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anticoagulants; Aspirin; Bevacizumab; Choroidal Neovascularization; Clopidogrel; Eye Hemorrhage; Female; Humans; Incidence; Intravitreal Injections; Macular Degeneration; Male; Middle Aged; Platelet Aggregation Inhibitors; Ranibizumab; Retrospective Studies; Risk Factors; Ticlopidine; Vascular Endothelial Growth Factor A; Warfarin | 2010 |
No inconsistent trial assessments by NICE and IQWiG: different assessment goals may lead to different assessment results regarding subgroup analyses.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; England; Evidence-Based Medicine; Germany; Humans; Prescription Drugs; Randomized Controlled Trials as Topic; Research Design; Ticlopidine | 2010 |
Acute myocardial infarction and renal infarction in a bodybuilder using anabolic steroids.
Topics: Adult; Anabolic Agents; Angiography; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Enoxaparin; Fibrinolytic Agents; Humans; Infarction; Kidney; Male; Methenolone; Myocardial Infarction; Oxymetholone; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Tomography, X-Ray Computed; Ultrasonography; Weight Lifting | 2010 |
Three-month dual antiplatelet therapy after implantation of zotarolimus-eluting stents: the DATE (Duration of Dual Antiplatelet Therapy AfterImplantation of Endeavor Stent) registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Agents; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Coronary Stenosis; Disease-Free Survival; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Feasibility Studies; Female; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Registries; Republic of Korea; Risk Assessment; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Platelet aggregation pathway.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cyclooxygenase 1; Cytochrome P-450 CYP2C19; Drug Resistance; Humans; Integrin beta3; Metabolic Networks and Pathways; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Polymorphism, Single Nucleotide; Ticlopidine | 2011 |
Impact of concomitant treatment with proton pump inhibitors and clopidogrel on clinical outcome in patients after coronary stent implantation.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Drug Therapy, Combination; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Patient Readmission; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Proton Pump Inhibitors; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Allergic reactions to clopidogrel and cross-reactivity to other agents.
Topics: Adrenal Cortex Hormones; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Desensitization, Immunologic; Diagnosis, Differential; Drug Hypersensitivity; Exanthema; Histamine Antagonists; Humans; Platelet Aggregation Inhibitors; Thienopyridines; Ticlopidine | 2011 |
Diabetics with acute coronary syndrome: advances, challenges, and uncertainties.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Diabetic Angiopathies; Humans; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2010 |
Management of severe bilateral carotid artery stenosis concomitant to severely symptomatic coronary arterial disease requiring coronary artery bypass grafting: a case-based review.
Topics: Carotid Artery Diseases; Carotid Stenosis; Clopidogrel; Coronary Artery Bypass; Endarterectomy, Carotid; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Preoperative Care; Stents; Stroke; Ticlopidine | 2010 |
Development and validation of an HPLC-MS/MS method to determine clopidogrel in human plasma. Use of incurred samples to test back-conversion.
Topics: Chromatography, High Pressure Liquid; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Reference Standards; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Ticlopidine | 2010 |
Letter by Lozano et al regarding article, "Increased risk of bleeding in patients on clopidogrel therapy after drug-eluting stents implantation: insights from the HMO Research Network-Stent Registry (HMORN-stent)".
Topics: Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Humans; Myocardial Infarction; Postoperative Hemorrhage; Prosthesis Implantation; Risk Factors; Survival Analysis; Ticlopidine; Withholding Treatment | 2010 |
Clopidogrel discontinuation and platelet reactivity following coronary stenting.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Clopidogrel; Collagen; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Epinephrine; Female; Humans; Ireland; Male; Middle Aged; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Tranexamic acid partially improves platelet function in patients treated with dual antiplatelet therapy.
Topics: Aged; Antifibrinolytic Agents; Aspirin; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Tranexamic Acid | 2011 |
Pilot study of the antiplatelet effect of increased clopidogrel maintenance dosing and its relationship to CYP2C19 genotype in patients with high on-treatment reactivity.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Body Mass Index; California; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Logistic Models; Longitudinal Studies; Male; Middle Aged; Phenotype; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Predictive Value of Tests; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Ticlopidine | 2010 |
Acceptance of high platelet reactivity as a risk factor: now, what do we do about it?
Topics: Aryl Hydrocarbon Hydroxylases; Body Mass Index; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Genotype; Humans; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Predictive Value of Tests; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Ticlopidine | 2010 |
Comparison of platelet P2Y(12) ADP receptor-mediated pathway inhibition in triple versus dual antiplatelet therapy as assessed by VASP-phosphorylation in Japanese patients undergoing coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Proteins; Cell Adhesion Molecules; Cilostazol; Clopidogrel; Diabetic Angiopathies; Female; Humans; Japan; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stents; Tetrazoles; Ticlopidine | 2010 |
The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.
Topics: Animals; Blood Platelets; Clopidogrel; Female; Flow Cytometry; Green Fluorescent Proteins; Guanine Nucleotide Exchange Factors; Hemostasis; Kinetics; Male; Mesentery; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2Y12; Signal Transduction; Thrombosis; Ticlopidine | 2011 |
Inhibition of vascular ectonucleotidase activities by the pro-drugs ticlopidine and clopidogrel favours platelet aggregation.
Topics: 5'-Nucleotidase; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Antigens, CD; Apyrase; Chlorocebus aethiops; Clopidogrel; COS Cells; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Hydrolysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Rats; Species Specificity; Ticlopidine; Umbilical Veins | 2010 |
Low risk of intracranial and systemic hemorrhages in patients on dual antiplatelet treatment beyond 1 month following neuroendovascular angioplasty and/or stent placement.
Topics: Angioplasty; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Combined Modality Therapy; Comorbidity; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Minnesota; Platelet Aggregation Inhibitors; Prevalence; Radiography; Risk Assessment; Risk Factors; Stents; Survival Analysis; Survival Rate; Ticlopidine; Treatment Outcome | 2012 |
Clopidogrel and the reduced-function CYP2C19 genetic variant: a limited piece of the overall therapeutic puzzle.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Patient Selection; Pharmacogenetics; Platelet Aggregation Inhibitors; Risk; Stents; Ticlopidine | 2010 |
Plaque distribution in clopidogrel responders and low responders as determined by multislice computed tomography.
Topics: Aged; Calcinosis; Clopidogrel; Coronary Angiography; Coronary Stenosis; Drug Resistance; Female; Germany; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Predictive Value of Tests; Severity of Illness Index; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2010 |
[Effect of duration of clopidogrel use on clinical follow-up outcomes in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention].
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Frequency of left ventricular thrombus in patients with anterior wall acute myocardial infarction treated with percutaneous coronary intervention and dual antiplatelet therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Chi-Square Distribution; Clopidogrel; Combined Modality Therapy; Coronary Thrombosis; Creatine Kinase; Echocardiography; Female; Heart Ventricles; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prevalence; Statistics, Nonparametric; Stents; Ticlopidine; Tomography, Emission-Computed, Single-Photon | 2010 |
Comparison of 600 versus 300-mg Clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary coronary angioplasty.
Topics: Aged; Angioplasty, Balloon, Coronary; Chi-Square Distribution; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Female; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; No-Reflow Phenomenon; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Registries; Survival Rate; Ticlopidine; Treatment Outcome | 2010 |
Peak cardiac troponin-T level, scintigraphic myocardial infarct size and one-year prognosis in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Clopidogrel; Combined Modality Therapy; Creatine Kinase, MB Form; Female; Germany; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Perfusion Imaging; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Radiopharmaceuticals; Registries; Technetium Tc 99m Sestamibi; Ticlopidine; Tomography, Emission-Computed, Single-Photon; Troponin T | 2010 |
PPIs and clopidogrel: the band plays on............
Topics: Bias; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2010 |
Resistance to aspirin and clopidogrel therapy.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
[Efficacy of stents coated with antibody against CD105 on preventing restenosis and thrombosis in minipigs].
Topics: Animals; Antibodies; Antigens, CD; Aspirin; Clopidogrel; Coronary Restenosis; Endothelial Cells; Neointima; Stents; Swine; Swine, Miniature; Thrombosis; Ticlopidine | 2010 |
Role of intramural platelet thrombus in the pathogenesis of wall rupture and intra-ventricular thrombosis following acute myocardial infarction.
Topics: Animals; Aspirin; Blood Platelets; Clopidogrel; Disease Models, Animal; Hemodynamics; Inflammation; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Myocardial Infarction; Platelet Aggregation Inhibitors; Telemetry; Thrombosis; Ticlopidine; Time Factors; Ventricular Septal Rupture | 2011 |
Paradoxical embolism.
Topics: Aged; Aspirin; Clopidogrel; Dipyridamole; Dyspnea; Echocardiography, Transesophageal; Embolism, Paradoxical; Female; Heart Atria; Humans; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Walking | 2010 |
Interaction of clopidogrel and omeprazole.
Topics: Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Emerging oral antiplatelet therapies for acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Aspirin; Cardiology; Clopidogrel; Drug Therapy, Combination; Emergency Medicine; Hemorrhage; Hospitalists; Humans; Imines; Lactones; Patient Selection; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Antagonists; Pyridines; Receptor, PAR-1; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Clinical impact of enhanced inhibition of P2Y12-mediated platelet aggregation in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.
Topics: Adenosine; Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Antibodies; Blood Platelets; Capillary Permeability; Case-Control Studies; CD11b Antigen; CD40 Ligand; Clopidogrel; Flow Cytometry; Hemoglobin Subunits; Humans; Hypoxia; Lung; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neutrophil Activation; Neutrophils; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Respiratory Burst; Ticlopidine | 2010 |
2-chlorophenyl zinc bromide: a convenient nucleophile for the mannich-related multicomponent synthesis of clopidogrel and ticlopidine.
Topics: Bromides; Clopidogrel; Cobalt; Molecular Structure; Platelet Aggregation Inhibitors; Ticlopidine; Zinc; Zinc Compounds | 2010 |
Influence of antiplatelet drugs in the pathogenesis of experimental periodontitis and periodontal repair in rats.
Topics: Alveolar Bone Loss; Animals; Aspirin; Blood Platelets; Bone Density; Bone Regeneration; Clopidogrel; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Interleukin-6; Leukocytes; Male; Mandibular Diseases; Periodontal Attachment Loss; Periodontitis; Periodontium; Platelet Activation; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Thromboxane A2; Ticlopidine; Time Factors; Tumor Necrosis Factor-alpha; Wound Healing; X-Ray Microtomography | 2011 |
The cytochrome 2C19*2 and *3 alleles attenuate response to clopidogrel similarly in East Asian patients undergoing elective percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Asian People; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Republic of Korea; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Is ticagrelor the antiplatelet therapy panacea?
Topics: Adenosine; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2010 |
Risk of recurrent myocardial infarction with the concomitant use of clopidogrel and proton pump inhibitors.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Combined Modality Therapy; Confounding Factors, Epidemiologic; Drug Interactions; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Regression Analysis; Risk Factors; Ticlopidine; Young Adult | 2011 |
Nontraumatic bilateral subdural hematoma caused by antiaggregation therapy: case report and review of the literature.
Topics: Adenosine Diphosphate; Aspirin; Clopidogrel; Female; Hematoma, Subdural; Humans; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Radiography; Ticlopidine | 2010 |
Coprescription of clopidogrel and proton pump inhibitors.
Topics: Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Secondary Prevention; Ticlopidine | 2010 |
A case of resistance to clopidogrel and prasugrel after percutaneous coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Antineoplastic Agents; Clopidogrel; Docetaxel; Drug Resistance; Drug-Eluting Stents; Humans; Male; Middle Aged; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Taxoids; Thiophenes; Thrombosis; Ticlopidine | 2011 |
A case of late epidural hematoma in a patient on clopidogrel therapy postoperatively: when is it safe to resume antiplatelet agents?
Topics: Clopidogrel; Decompression, Surgical; Hematoma, Epidural, Spinal; Humans; Lumbar Vertebrae; Male; Middle Aged; Platelet Aggregation Inhibitors; Spinal Fusion; Spinal Stenosis; Spondylolisthesis; Stents; Thrombosis; Ticlopidine | 2011 |
Association between smoking, outcomes, and early clopidogrel use in patients with acute coronary syndrome: insights from the Global Registry of Acute Coronary Events.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Coronary Angiography; Electrocardiography; Female; Follow-Up Studies; Hemorrhage; Hospital Mortality; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Registries; Risk Factors; Smoking; Survival Rate; Ticlopidine; Time Factors | 2010 |
National estimates of emergency department visits for hemorrhage-related adverse events from clopidogrel plus aspirin and from warfarin.
Topics: Acute Disease; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Emergency Service, Hospital; Female; Health Care Surveys; Hemorrhage; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Sex Distribution; Ticlopidine; United States; Warfarin; Young Adult | 2010 |
Prasugrel and cancer.
Topics: Clinical Trials as Topic; Clopidogrel; Humans; Neoplasms; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2010 |
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus after drug-eluting stent implantation in Japanese patients receiving clopidogrel.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Asian People; Cardiovascular Agents; Chi-Square Distribution; Cineangiography; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Japan; Logistic Models; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prosthesis Design; Risk Assessment; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Time Factors; Tomography, Optical Coherence; Treatment Outcome | 2011 |
[Individual pharmacotherapy safety in the assessment of cytochrome P-450 3A4 (CYP3A4) isoenzyme activity].
Topics: Atorvastatin; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Ischemia; Pharmacokinetics; Platelet Aggregation Inhibitors; Precision Medicine; Pyrroles; Ticlopidine | 2010 |
Second-generation thienopyridine use is not associated with better early perioperative outcome during carotid stenting.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Angioplasty; Asymptomatic Diseases; Carotid Stenosis; Chi-Square Distribution; Clopidogrel; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Italy; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
[Evidence-based management of ST-segment elevation myocardial infarction (STEMI). Latest guidelines of the European Society of Cardiology (ESC) 2010].
Topics: Aftercare; Anticoagulants; Cardiovascular Agents; Clopidogrel; Combined Modality Therapy; Contraindications; Electrocardiography; Emergency Medical Services; Emergency Service, Hospital; Europe; Evidence-Based Medicine; Humans; Life Style; Myocardial Infarction; Myocardial Reperfusion; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Thiophenes; Thrombolytic Therapy; Ticlopidine; Time Factors | 2010 |
[Between thrombosis and bleeding - a case of paroxysmal nocturnal hemoglobinuria].
Topics: Aged; Anticoagulants; Aspirin; Cerebral Hemorrhage; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Fatal Outcome; Female; Hemoglobinuria, Paroxysmal; Heparin; Heparin, Low-Molecular-Weight; Humans; Phenprocoumon; Platelet Aggregation Inhibitors; Ticlopidine; Tomography, X-Ray Computed | 2010 |
An algorithm for use of prasugrel (effient) in patients undergoing cardiac catheterization and percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Cardiac Catheterization; Clinical Protocols; Clinical Trials as Topic; Clopidogrel; Comparative Effectiveness Research; Guidelines as Topic; Hemorrhage; Humans; Myocardial Infarction; Patient Care Planning; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Assessment; Standard of Care; Thiophenes; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2010 |
Antiplatelet therapy effectively reduces plasma plasminogen activator inhibitor-1 levels.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Case-Control Studies; Clopidogrel; Down-Regulation; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Ischaemic stroke--prevention is better than cure.
Topics: Adult; Age Factors; Aged; Anticoagulants; Antihypertensive Agents; Aspirin; Atrial Fibrillation; Blood Glucose; Cholesterol; Clopidogrel; Confidence Intervals; Decompression, Surgical; Endarterectomy, Carotid; Fibrinolytic Agents; Glycated Hemoglobin; Humans; Incidence; Middle Aged; Platelet Aggregation Inhibitors; Prevalence; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Smoking Cessation; Stroke; Ticlopidine | 2010 |
Delayed intracranial hemorrhage associated with antiplatelet therapy in stent-assisted coil embolized cerebral aneurysms.
Topics: Adult; Aged; Aspirin; Cerebral Hemorrhage; Clopidogrel; Cohort Studies; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Imaging, Three-Dimensional; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Tomography Scanners, X-Ray Computed | 2011 |
[Should we believe in the interaction between proton pump inhibitors (PPI) and clopidogrel].
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine | 2010 |
Clinical predictors of high posttreatment platelet reactivity to clopidogrel in Koreans.
Topics: Age Factors; Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Asian People; Biomarkers; Blood Platelets; C-Reactive Protein; Chi-Square Distribution; Chronic Disease; Clopidogrel; Diabetes Mellitus; Female; Humans; Kidney Diseases; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Republic of Korea; Risk Assessment; Risk Factors; Sex Factors; Smoking; Stents; Ticlopidine; Treatment Outcome | 2012 |
Hybrid revascularization, comprising coronary artery bypass graft with exclusive arterial conduits followed by early drug-eluting stent implantation, in multivessel coronary artery disease.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Case-Control Studies; Chi-Square Distribution; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Coronary Artery Disease; Drug-Eluting Stents; Feasibility Studies; Female; France; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2010 |
Significant increase in clopidogrel use across U.S. children's hospitals.
Topics: Adolescent; Child; Child, Preschool; Clopidogrel; Coronary Thrombosis; Databases, Factual; Drug Therapy, Combination; Female; Heart Defects, Congenital; Hospitals, Pediatric; Humans; Infant; Infant, Newborn; Inpatients; Length of Stay; Male; Mortality; Pediatrics; Platelet Aggregation Inhibitors; Poisson Distribution; Pulmonary Embolism; Retrospective Studies; Risk Assessment; Stroke; Ticlopidine; United States; Venous Thromboembolism | 2011 |
Combination of low-dose aspirin and thienopyridine exacerbates small bowel injury.
Topics: Aged; Aged, 80 and over; Aspirin; Capsule Endoscopy; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Intestinal Mucosa; Intestine, Small; Male; Middle Aged; Pyridines; Retrospective Studies; Ticlopidine; Ulcer; Warfarin | 2011 |
[Efficacy and safety of concomitant use of rabeprazole during dual-antiplatelet therapy with clopidogrel and aspirin after drug-eluting stent implantation: a retrospective cohort study].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cohort Studies; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Interactions; Drug-Eluting Stents; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Rabeprazole; Retrospective Studies; Ticlopidine; Treatment Outcome | 2010 |
Upper digestive bleeding due to Dieulafoy´s lesion during the postoperative period of aortocoronary bypass surgery in a patient treated with clopidogrel.
Topics: Aged; Arterioles; Clopidogrel; Coronary Artery Bypass; Gastrointestinal Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Stomach; Ticlopidine | 2010 |
What is the optimal duration of triple anti-platelet therapy in patients with acute myocardial infarction undergoing drug-eluting stent implantation?
Topics: Aspirin; Cilostazol; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Tetrazoles; Ticlopidine; Time Factors | 2011 |
Thromboresistant surfaces with low-dose anticoagulation alleviate clopidogrel-related complications in patients undergoing coronary artery bypass grafting.
Topics: Aged; Anticoagulants; Biocompatible Materials; Blood Loss, Surgical; Blood Transfusion; Boston; Chest Tubes; Chi-Square Distribution; Clopidogrel; Coronary Artery Bypass; Drainage; Drug Administration Schedule; Equipment Design; Female; Heparin; Humans; Length of Stay; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Antiplatelet and antithrombotic treatment after primary percutaneous coronary intervention: balancing safety and efficacy.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Fibrinolytic Agents; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Assessment; Safety; Secondary Prevention; Thiophenes; Ticlopidine; Treatment Outcome; Warfarin | 2010 |
Enhanced clopidogrel responsiveness in smokers: smokers' paradox is dependent on cytochrome P450 CYP1A2 status.
Topics: Aged; Chi-Square Distribution; Clopidogrel; Cross-Sectional Studies; Cytochrome P-450 CYP1A2; Female; Gene Frequency; Genotype; Humans; Linear Models; Logistic Models; Male; Middle Aged; Odds Ratio; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Prospective Studies; Receptors, Purinergic P2Y12; Republic of Korea; Risk Assessment; Risk Factors; Smoking; Ticlopidine | 2011 |
[Acute myocardial infarction: importance of the networking in the initial management].
Topics: Clopidogrel; Humans; Information Services; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Switzerland; Thrombectomy; Ticlopidine | 2010 |
Dosing of clopidogrel and aspirin in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Algorithms; Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Dosing of clopidogrel and aspirin in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Antagonism; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Dosing of clopidogrel and aspirin in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Estimation of financial burden due to oversupply of medications for chronic diseases.
Topics: Aged; Atorvastatin; Chronic Disease; Clopidogrel; Drug Costs; Female; Heptanoic Acids; Hospitals, University; Humans; Male; Middle Aged; Pharmaceutical Preparations; Phenylcarbamates; Pyrroles; Retrospective Studies; Rivastigmine; Rosiglitazone; Tetrazoles; Thailand; Thiazolidinediones; Ticlopidine; Valine; Valsartan | 2012 |
Impact of CYP2C19 polymorphism and smoking on response to clopidogrel in patients with stable coronary artery disease.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2010 |
Concomitant use of proton pump inhibitors and clopidogrel in patients with coronary, cerebrovascular, or peripheral artery disease in the factores de Riesgo y ENfermedad Arterial (FRENA) registry.
Topics: Aged; Cerebrovascular Disorders; Clopidogrel; Contraindications; Coronary Artery Disease; Drug Interactions; Female; Humans; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Registries; Retrospective Studies; Stroke; Ticlopidine | 2011 |
In brief: Clopidogrel and omeprazole.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Impact of CYP2C19 polymorphism on residual platelet reactivity in patients with coronary heart disease during antiplatelet therapy.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Asian People; Cardiovascular Diseases; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Endovascular Procedures; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Ticlopidine | 2011 |
Paraoxonase-1 is a major determinant of clopidogrel efficacy.
Topics: Amino Acid Substitution; Aryldialkylphosphatase; Biotransformation; Clopidogrel; Coronary Disease; Follow-Up Studies; Genotype; Homozygote; Humans; Kinetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Substrate Specificity; Survival Analysis; Ticlopidine; Time Factors | 2011 |
Proton pump inhibitors: Adverse effects.
Topics: Calcium; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Female; Follow-Up Studies; Gastroesophageal Reflux; Humans; Laryngopharyngeal Reflux; Male; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Stomach Diseases; Stomach Neoplasms; Ticlopidine | 2010 |
Differential impacts of CYP2C19 gene polymorphisms on the antiplatelet effects of clopidogrel and ticlopidine.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2011 |
Measurement of platelet reactivity of patients with cardiovascular disease on-treatment with acetyl salicylic acid: a prospective study.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Humans; Logistic Models; Male; Medication Adherence; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Assessment; Risk Factors; Sex Factors; Ticlopidine; Treatment Outcome | 2011 |
An early and simple predictor of severe left main and/or three-vessel disease in patients with non-ST-segment elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Biomarkers; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Early Diagnosis; Electrocardiography; Female; Heart Conduction System; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Ticlopidine; Treatment Outcome; Troponin T | 2011 |
Frequency and location of yellow and disrupted coronary plaques in patients as detected by angioscopy.
Topics: Acute Coronary Syndrome; Aged; Angioscopy; Aspirin; Clopidogrel; Coronary Artery Disease; Disease Progression; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Retrospective Studies; Severity of Illness Index; Ticlopidine | 2011 |
What you need to know about Clopidogrel. This drug helps to prevent the blood clots that can cause heart attacks and stroke.
Topics: Clopidogrel; Health Knowledge, Attitudes, Practice; Heart Diseases; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine | 2009 |
Light transmittance aggregometry induced by different concentrations of adenosine diphosphate to monitor clopidogrel therapy: a methodological study.
Topics: Adenosine Diphosphate; Angioplasty; Clopidogrel; Coronary Artery Disease; Drug Monitoring; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Point-of-Care Systems; Ticlopidine | 2011 |
Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Postoperative Hemorrhage; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine | 2011 |
Mechanisms potentially contributing to the reduction in mortality associated with ticagrelor therapy.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Postoperative Hemorrhage; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2011 |
More on: adenosine diphosphate-inducible platelet reactivity shows a pronounced age dependency in the initial phase of antiplatelet therapy with clopidogrel.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aging; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors | 2011 |
Beware of being caught on the rebound.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
[Better understanding of combination use of clopidogrel and proton pump inhibitor].
Topics: Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Proton Pump Inhibitors; Ticlopidine | 2010 |
The CHD challenge: comparing four cost-effectiveness models.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Cost-Benefit Analysis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Models, Econometric; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine; United Kingdom | 2011 |
Endovascular management of patients with critical limb ischemia.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Angioplasty, Balloon; Boston; Clopidogrel; Critical Illness; Female; Humans; Ischemia; Kaplan-Meier Estimate; Limb Salvage; Lower Extremity; Male; Middle Aged; Patient Selection; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2011 |
Evaluation of clopidogrel resistance in ischemic stroke patients.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Brain Ischemia; Clopidogrel; Drug Resistance; Female; Humans; In Vitro Techniques; Male; Middle Aged; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2011 |
[Current status of medical therapy of chronic stable angina pectoris in mainland of China: the second survey].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angina Pectoris; Angiotensin Receptor Antagonists; Aspirin; China; Chronic Disease; Clopidogrel; Cross-Sectional Studies; Female; Guideline Adherence; Health Care Surveys; Humans; Male; Middle Aged; Surveys and Questionnaires; Ticlopidine | 2010 |
Clopidogrel Resistance: case reports of CYP2C19 gene variants in suspected coronary stent thrombosis.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Stenosis; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Genotype; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Stents; Thrombosis; Ticlopidine | 2011 |
A new clopidogrel (Plavix) point-of-care assay: rapid determination of antiplatelet activity in trauma patients.
Topics: Aged; Clopidogrel; Female; Hemorrhage; Humans; Injury Severity Score; Male; Platelet Aggregation Inhibitors; Point-of-Care Systems; Retrospective Studies; Ticlopidine; Wounds and Injuries | 2011 |
Catapulting clopidogrel pharmacogenomics forward.
Topics: Amino Acid Substitution; Aryldialkylphosphatase; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticlopidine | 2011 |
Behind the paper: stepping up to the antiplatelet.
Topics: Amino Acid Sequence; Aryldialkylphosphatase; Aspirin; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 Enzyme System; Drug Tolerance; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Humanized mouse model of thrombosis is predictive of the clinical efficacy of antiplatelet agents.
Topics: Animals; Biomarkers; Cell Adhesion; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Humans; Mice; Mice, 129 Strain; Mice, Mutant Strains; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Predictive Value of Tests; Receptors, Purinergic P2Y12; Species Specificity; Thrombosis; Ticlopidine; Transplantation, Heterologous; von Willebrand Factor | 2011 |
Lack of correlation between platelet reactivity and glycaemic control in type 2 diabetes mellitus patients treated with aspirin and clopidogrel.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Aspirin; Blood Glucose; Blood Platelets; Clopidogrel; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Glycemic Index; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Time Factors | 2011 |
Simultaneous determination of clopidogrel and aspirin by RP-HPLC from bulk material and dosage formulations using multivariate calibration technique.
Topics: Aspirin; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Clopidogrel; Linear Models; Multivariate Analysis; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine | 2011 |
Functional profile of the platelet P2Y₁₂ receptor signalling pathway in patients with type 2 diabetes mellitus and coronary artery disease.
Topics: Aged; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Thrombosis; Ticlopidine | 2011 |
[Renal artery stenosis: angioplasty or drug treatment?].
Topics: Aged; Angioplasty; Anticoagulants; Antihypertensive Agents; Aspirin; Blood Pressure; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Combined Modality Therapy; Creatinine; Diagnostic Imaging; Female; Follow-Up Studies; Germany; Glomerular Filtration Rate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Renovascular; Male; Middle Aged; Renal Artery Obstruction; Renal Dialysis; Retrospective Studies; Risk Factors; Survival Rate; Ticlopidine | 2011 |
"Short" thrombelastography as a test of platelet reactivity in response to antiplatelet therapy: validation and reproducibility.
Topics: Aspirin; Blood Platelets; Clopidogrel; Humans; Individuality; Platelet Aggregation; Platelet Aggregation Inhibitors; Reproducibility of Results; Thrombelastography; Ticlopidine | 2011 |
Clinical follow-up 3 years after everolimus- and paclitaxel-eluting stents: a pooled analysis from the SPIRIT II (A Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Arte
Topics: Angioplasty, Balloon, Coronary; Antineoplastic Agents, Phytogenic; Aspirin; Clopidogrel; Confidence Intervals; Coronary Artery Disease; Drug-Eluting Stents; Everolimus; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Proportional Hazards Models; Randomized Controlled Trials as Topic; Risk; Risk Reduction Behavior; Sirolimus; Ticlopidine; Time Factors | 2010 |
Lipopolysaccharide down-regulates carbolesterases 1 and 2 and reduces hydrolysis activity in vitro and in vivo via p38MAPK-NF-κB pathway.
Topics: Animals; Blotting, Western; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Survival; Cells, Cultured; Clopidogrel; Down-Regulation; Enzyme Inhibitors; Genes, Reporter; Humans; Hydrolysis; Irinotecan; Lipopolysaccharides; Male; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Platelet Aggregation Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Subcellular Fractions; Ticlopidine; Transfection | 2011 |
[Antiplatelet agents in acute coronary syndromes. Data from the main clinical trials].
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clinical Trials as Topic; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2010 |
[Antiplatelet agents and diabetes mellitus].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Diabetes Mellitus, Type 2; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Factors associated with clopidogrel use, adherence, and persistence in patients with acute coronary syndromes undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Combined Modality Therapy; Female; Humans; Male; Medication Adherence; Middle Aged; Patient Compliance; Platelet Aggregation Inhibitors; Retrospective Studies; Socioeconomic Factors; Stents; Ticlopidine; United States | 2011 |
Antiplatelet drugs in the elderly: prescriptions often inappropriate and reduced tolerance by associated diseases and drugs.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; France; Hemorrhage; Humans; Male; Off-Label Use; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Prospective Studies; Risk Factors; Ticlopidine | 2012 |
Overview of the 2010 Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee meeting regarding ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Advisory Committees; Aspirin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Clopidogrel; Drug Approval; Humans; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thrombosis; Ticagrelor; Ticlopidine; United States | 2011 |
Effects of proton pump inhibitors in patients receiving clopidogrel: meta-analysis versus clinical practice.
Topics: Clopidogrel; Drug Therapy, Combination; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proton Pump Inhibitors; Risk; Ticlopidine | 2011 |
CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brazil; Clopidogrel; Cytochrome P-450 CYP2C19; Ethnicity; Female; Gene Frequency; Humans; Indians, South American; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; White People | 2011 |
Management of clopidogrel hypersensitivity without drug interruption.
Topics: Adrenal Cortex Hormones; Cardiac Catheterization; Clopidogrel; Coronary Thrombosis; Drug Hypersensitivity; Drug-Eluting Stents; Female; Histamine Antagonists; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2011 |
Effect of concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Case-Control Studies; Chi-Square Distribution; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proportional Hazards Models; Proton Pump Inhibitors; Stents; Ticlopidine; Veterans | 2011 |
Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Cause of Death; Clopidogrel; Cohort Studies; Coronary Stenosis; Female; Glomerular Filtration Rate; Humans; Kaplan-Meier Estimate; Kidney Function Tests; Male; Middle Aged; Prospective Studies; Purinergic P2Y Receptor Antagonists; Reference Values; Renal Insufficiency, Chronic; Risk Assessment; Survival Analysis; Ticlopidine | 2011 |
Calcium-channel blockers do not alter the clinical efficacy of clopidogrel after myocardial infarction: a nationwide cohort study.
Topics: Aged; Calcium Channel Blockers; Cause of Death; Clopidogrel; Cohort Studies; Confidence Intervals; Denmark; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Proportional Hazards Models; Registries; Retrospective Studies; Survival Analysis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Endothelial progenitor cell capturing stent and short dual antiplatelet therapy in patients on chronic anti-vitamin k regimen undergoing percutaneous coronary interventions: long-term outcomes of a single centre registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coated Materials, Biocompatible; Coronary Disease; Disease-Free Survival; Endothelial Cells; Female; Humans; Male; Platelet Aggregation Inhibitors; Stem Cells; Stents; Ticlopidine; Vitamin K | 2011 |
One-year clinical outcome in patients with acute coronary syndrome treated with concomitant use of clopidogrel and proton pump inhibitors: results from a regional cohort study.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Chi-Square Distribution; Clopidogrel; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Italy; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Patient Readmission; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Clopidogrel differentially affects platelet-mediated thrombosis and inflammatory response in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Female; Humans; Inflammation; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2011 |
Invited commentary.
Topics: Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Artery Disease; Drainage; Humans; Intubation, Gastrointestinal; Minimally Invasive Surgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Premedication; Sternotomy; Thrombosis; Ticlopidine | 2011 |
Double-dose clopidogrel in patients undergoing PCI for ACS.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2011 |
Double-dose clopidogrel in patients undergoing PCI for ACS.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2011 |
Usefulness of platelet response to clopidogrel by point-of-care testing to predict bleeding outcomes in patients undergoing percutaneous coronary intervention (from the Antiplatelet Therapy for Reduction of Myocardial Damage During Angioplasty-Bleeding St
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hemorrhage; Humans; Long-Term Care; Male; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Predictive Value of Tests; Premedication; Prospective Studies; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2011 |
Resistance to anti-platelet agents.
Topics: Adenosine; Aspirin; Clopidogrel; Drug Resistance; Humans; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2011 |
CYP2C19 genotype and proton pump inhibitors in clopidogrel-treated patients: does it take two to tango?
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocard
Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; France; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Registries; Ticlopidine; Treatment Outcome | 2011 |
Proton pump inhibitors in patients treated with aspirin and clopidogrel after acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2010 |
Proton pump inhibitor co-therapy with clopidogrel: is there GI benefit or cardiovascular harm?
Topics: Atherosclerosis; Clopidogrel; Drug Interactions; Humans; Omeprazole; Peptic Ulcer; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Secondary Prevention; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Pharmacogenetics and clopidogrel response in patients undergoing percutaneous coronary interventions.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Exercise Test; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Low responsiveness to clopidogrel increases risk among CKD patients undergoing coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Chronic Disease; Clopidogrel; Cohort Studies; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hemorrhage; Humans; Kidney Diseases; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2011 |
Optimal antithrombotic therapy in patients receiving long-term oral anticoagulation requiring percutaneous coronary intervention: "triple therapy" or "triple threat".
Topics: Administration, Oral; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Heart Diseases; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stents; Stroke; Thromboembolism; Ticlopidine; Warfarin | 2011 |
Carriage of reduced-function CYP2C19 allele among patients treated with clopidogrel.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Bias; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Publication Bias; Reproducibility of Results; Ticlopidine | 2011 |
Clopidogrel improves endothelial function and NO bioavailability by sensitizing adenylyl cyclase in rats with congestive heart failure.
Topics: Adenylyl Cyclases; Animals; Aorta; Blotting, Western; Clopidogrel; Endothelium, Vascular; Heart Failure; Male; Nitric Oxide; Purinergic P2Y Receptor Antagonists; Rats; Rats, Wistar; Ticlopidine; Vasodilation | 2011 |
CYP2C19 genotype and outcomes of clopidogrel treatment.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Mutation; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
CYP2C19 genotype and outcomes of clopidogrel treatment.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Atrial Fibrillation; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Mutation; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2011 |
Relationship between peripheral arterial reactive hyperemia and residual platelet reactivity after 600 mg clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Hyperemia; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Time Factors | 2011 |
Antiplatelet agents do not impact the hospital course in patients with gastrointestinal bleeding.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Cohort Studies; Dizziness; Female; Gastrointestinal Hemorrhage; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Treatment Outcome; Young Adult | 2011 |
Comparison of 600 versus 300-mg clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Electrocardiography; Heart Conduction System; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Recurrent myocardial infarction due to one subacute and two very late thrombotic events of drug-eluting stent associated with clopidogrel resistance.
Topics: Adult; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Resistance; Drug-Eluting Stents; Electrocardiography; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 2011 |
TIAs - management in general practice.
Topics: Anticoagulants; Antihypertensive Agents; Aspirin; Atorvastatin; Clopidogrel; Dipyridamole; Dopamine Antagonists; General Practitioners; Heptanoic Acids; Humans; Hypolipidemic Agents; Ischemic Attack, Transient; Perindopril; Platelet Aggregation Inhibitors; Primary Health Care; Prochlorperazine; Pyrroles; Ticlopidine; Vasodilator Agents; Warfarin | 2010 |
An improved method for specific and quantitative determination of the clopidogrel active metabolite isomers in human plasma.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; CHO Cells; Chromatography, High Pressure Liquid; Clopidogrel; Cricetinae; Cricetulus; Humans; Mass Spectrometry; Phosphorus Isotopes; Plasma; Product Surveillance, Postmarketing; Protein Binding; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Stereoisomerism; Thionucleotides; Ticlopidine; Transgenes | 2011 |
Endoscopic resection of bladder cancer in patients receiving double platelet antiaggregant therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Cardiac Surgical Procedures; Clopidogrel; Coronary Restenosis; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Urinary Bladder Neoplasms | 2011 |
[Relationships of blood stasis syndrome, CYP2C19 gene polymorphism with clopidogrel resistance and post-PCI prognosis].
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Diagnosis, Differential; Drug Resistance; Female; Humans; Male; Medicine, Chinese Traditional; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prognosis; Ticlopidine | 2010 |
Has the ClOpidogrel and Metoprolol in Myocardial Infarction Trial (COMMIT) of early β-blocker use in acute coronary syndromes impacted on clinical practice in Canada? Insights from the Global Registry of Acute Coronary Events (GRACE).
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Canada; Clopidogrel; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Registries; Retrospective Studies; Ticlopidine | 2011 |
Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: insights from the Korea Acute Myocardial Infarction Registry.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Registries; Republic of Korea; Retrospective Studies; Ticlopidine | 2011 |
Clopidogrel loading dose and bleeding outcomes in patients undergoing urgent coronary artery bypass grafting.
Topics: Aged; Clopidogrel; Coronary Artery Bypass; Emergency Treatment; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2011 |
Impact of smoking on acute phase outcomes of myocardial infarction.
Topics: Acute Disease; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Smoking; Ticlopidine; Treatment Outcome | 2011 |
Total occlusion of aortic arch in a 62-year-old man presenting with acute myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Aorta, Thoracic; Aortic Diseases; Clopidogrel; Coronary Angiography; Enoxaparin; Humans; Male; Middle Aged; Myocardial Infarction; Stents; Ticlopidine; Tomography, X-Ray Computed | 2011 |
Conversation with an expert. Plavix: what you need to know.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Costs; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Health Knowledge, Attitudes, Practice; Humans; Patient Education as Topic; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2011 |
Recurrent episodes of very late stent thrombosis in a patient with aspirin hypersensitivity, stent fracture and malapposition.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Occlusion; Coronary Thrombosis; Drug Hypersensitivity; Drug-Eluting Stents; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Failure; Recurrence; Ticlopidine; Time Factors; Tomography, Optical Coherence | 2011 |
Clopidogrel with or without omeprazole in coronary disease.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Cardiovascular Diseases; Chemistry, Pharmaceutical; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Clopidogrel with or without omeprazole in coronary disease.
Topics: Clopidogrel; Coronary Artery Disease; Cost-Benefit Analysis; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Clopidogrel use and short-term mortality after peptic ulcer bleeding: a population-based cohort study.
Topics: Adult; Aged; Aged, 80 and over; Atherosclerosis; Clopidogrel; Cohort Studies; Denmark; Female; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Prognosis; Proportional Hazards Models; Registries; Ticlopidine | 2013 |
The effect of clopidogrel and aspirin on blood loss in hip fracture surgery.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Drug Therapy, Combination; Female; Hip Fractures; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Treatment patterns in acute coronary syndrome patients in the United Kingdom undergoing PCI.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Female; Humans; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prospective Studies; Registries; Retreatment; Stents; Ticlopidine; United Kingdom | 2011 |
CYP2C19 and ABCB1 genes and individualized treatment with clopidogrel.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Variation; Humans; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine | 2011 |
Genetic substudy of the PLATO trial.
Topics: Acute Coronary Syndrome; Alleles; Angioplasty, Balloon, Coronary; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Genetic Carrier Screening; Humans; Premedication; Randomized Controlled Trials as Topic; Ticlopidine | 2011 |
Immortal person-time bias in observational studies in cardiac surgery.
Topics: Aspirin; Bias; Clopidogrel; Coronary Artery Bypass; Data Interpretation, Statistical; Drug Therapy, Combination; Hemorrhage; Hospital Mortality; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Research Design; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2011 |
Effects of antithrombogenic agents on microvenous anastomoses in a rat model.
Topics: Anastomosis, Surgical; Animals; Aspirin; Clopidogrel; Femoral Vein; Ketorolac Tromethamine; Microcirculation; Models, Animal; Platelet Aggregation Inhibitors; Random Allocation; Rats; Ticlopidine; Time Factors; Vascular Patency; Venous Thrombosis | 2011 |
[Active pharmacosurveillance of patients affiliated to the Colombian general social security/health system].
Topics: Adverse Drug Reaction Reporting Systems; Calcium Channel Blockers; Clopidogrel; Colombia; Diphosphonates; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Imidazoles; Losartan; Medication Systems; Metoprolol; National Health Programs; Omeprazole; Retrospective Studies; Social Security; Software; Ticlopidine; Zoledronic Acid | 2010 |
Stent-assisted thrombolysis in acute tandem carotid and middle cerebral arteries occlusion.
Topics: Acute Disease; Carotid Artery Thrombosis; Carotid Artery, Internal; Carotid Artery, Internal, Dissection; Clopidogrel; Follow-Up Studies; Humans; Infarction, Middle Cerebral Artery; Male; Middle Aged; Middle Cerebral Artery; Platelet Aggregation Inhibitors; Stents; Thrombolytic Therapy; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2010 |
High on-clopidogrel platelet reactivity: genotyping can help to optimize antiplatelet treatment.
Topics: Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Ticlopidine | 2011 |
Did clopidogrel confound the results?
Topics: Clopidogrel; Coronary Artery Bypass, Off-Pump; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Stroke; Ticlopidine | 2011 |
Does preoperative clopidogrel increase bleeding after coronary bypass surgery?
Topics: Adult; Aged; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Female; Humans; India; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Prospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Risk of upper gastrointestinal bleeding with low-dose acetylsalicylic acid alone and in combination with clopidogrel and other medications.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Case-Control Studies; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk; Ticlopidine; United Kingdom | 2011 |
Safety of clopidogrel and proton pump inhibitors in patients undergoing drug-eluting stent implantation.
Topics: Acute Coronary Syndrome; Aged; Blood Vessel Prosthesis Implantation; Clopidogrel; Cohort Studies; Combined Modality Therapy; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Ticlopidine | 2011 |
Identification of CYP2C19*4B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Clopidogrel; Cytochrome P-450 CYP2C19; Gene Frequency; Genotype; Humans; Jews; Pharmacogenetics; Ticlopidine | 2012 |
Toxic epidermal necrolysis after percutaneous coronary intervention: which drug is the culprit?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Humans; Male; Middle Aged; Stevens-Johnson Syndrome; Ticlopidine | 2011 |
[Coronary stent thrombosis in concurrent clopidogrel and proton pump inhibitor therapy].
Topics: Clopidogrel; Coronary Thrombosis; Drug Interactions; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2011 |
Efficacy of post-operative clopidogrel treatment in patients revascularized with coronary artery bypass grafting after myocardial infarction.
Topics: Aged; Clopidogrel; Combined Modality Therapy; Comorbidity; Coronary Artery Bypass; Denmark; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Period; Propensity Score; Proportional Hazards Models; Registries; Secondary Prevention; Ticlopidine | 2011 |
Impact of concomitant use of proton-pump inhibitors and thienopyridine derivatives on the antiplatelet effects.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Disease; Drug Interactions; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stents; Thienopyridines; Ticlopidine | 2011 |
Endovascular treatment using predominantly stent-assisted coil embolization and antiplatelet and anticoagulation management of ruptured blood blister-like aneurysms.
Topics: Adult; Aged; Aneurysm, Ruptured; Anticoagulants; Aspirin; Cerebral Angiography; Clopidogrel; Combined Modality Therapy; Embolization, Therapeutic; Female; Follow-Up Studies; Heparin; Humans; Intracranial Aneurysm; Intracranial Thrombosis; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Secondary Prevention; Stents; Ticlopidine | 2011 |
Clopidogrel and modified-release dipyridamole for the prevention of occlusive vascular events (NICE technology appraisal guidance 90).
Topics: Aspirin; Clopidogrel; Constriction, Pathologic; Delayed-Action Preparations; Dipyridamole; Drugs, Generic; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine; Vascular Diseases | 2011 |
Clopidogrel hyporesponsiveness and the FDA boxed warning: detection and management of patients with genetic polymorphisms.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Labeling; Genetic Testing; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; United States; United States Food and Drug Administration | 2011 |
Treatment of GERD and proton pump inhibitor use in the elderly: practical approaches and frequently asked questions.
Topics: Adenocarcinoma; Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Aspirin; Barrett Esophagus; Clopidogrel; Drug Interactions; Drug Prescriptions; Esophageal Neoplasms; Esophagitis; Esophagoscopy; Gastroesophageal Reflux; Gastroscopy; Heartburn; Hip Fractures; Humans; Intestinal Absorption; Middle Aged; Obesity; Odds Ratio; Platelet Aggregation Inhibitors; Population Surveillance; Prevalence; Proton Pump Inhibitors; Ticlopidine; Vitamin B 12 | 2011 |
What is the best antiplatelet agent for prevention of recurrent stroke in Pakistani patients? Do combinations offer significant advantages in the South Asian context?
Topics: Asian People; Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Evidence-Based Medicine; Follow-Up Studies; Humans; Pakistan; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2010 |
What is the best first agent to give to a patient with acute ischaemic stroke? Aspirin, heparin, clopidogrel, cilostazol or dipyridamole?
Topics: Aspirin; Brain Ischemia; Cilostazol; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Evidence-Based Medicine; Fibrinolytic Agents; Heparin; Humans; Platelet Aggregation Inhibitors; Stroke; Tetrazoles; Ticlopidine | 2010 |
Viewpoint: paradoxical excess mortality in the PLATO trial should be independently verified.
Topics: Acute Coronary Syndrome; Adenosine; Bias; Clinical Trials as Topic; Clopidogrel; Europe; Humans; Mortality; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome; United States; United States Food and Drug Administration | 2011 |
Relapsed spontaneous spinal epidural hematoma associated with aspirin and clopidogrel.
Topics: Aspirin; Clopidogrel; Hematoma, Epidural, Spinal; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurologic Examination; Platelet Aggregation Inhibitors; Recurrence; Spine; Stroke; Ticlopidine; Tomography, X-Ray Computed | 2011 |
Clinical outcomes in patients with the concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention: an analysis from the Guthrie Health Off-Label Stent (GHOST) investigators.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2011 |
Antiplatelet pretreatment does not increase hematoma volume in experimental intracerebral hemorrhage.
Topics: Animals; Aspirin; Blood Coagulation; Cerebral Hemorrhage; Clopidogrel; Hematoma; Mice; Plasma Cells; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Failure | 2011 |
[Assessing clinical efficacy of the generic clopidogrel "Egutromb" in roentgenosurgical practice].
Topics: Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Dose-Response Relationship, Drug; Drugs, Generic; Humans; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2010 |
Oral antiplatelet therapy for atherothrombotic disease: current evidence and new directions.
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Humans; Lactones; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Pyridines; Quinazolinones; Randomized Controlled Trials as Topic; Receptor, PAR-1; Sulfonamides; Ticagrelor; Ticlopidine | 2011 |
The relation between CYP2C19 genotype and phenotype in stented patients on maintenance dual antiplatelet therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Linkage Disequilibrium; Male; Middle Aged; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2011 |
Lack of impact of calcium-channel blockers on the pharmacodynamic effect and the clinical efficacy of clopidogrel after drug-eluting stenting.
Topics: Aged; Calcium Channel Blockers; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Thrombosis; Drug Synergism; Drug-Eluting Stents; Endpoint Determination; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2011 |
Explaining the unexpected: insights from the PLATelet inhibition and clinical Outcomes (PLATO) trial comparing ticagrelor and clopidogrel. Editorial on Serebruany "Viewpoint: Paradoxical excess mortality in the PLATO trial should be independently verified
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials as Topic; Clopidogrel; Epidemiologic Research Design; Europe; Humans; Patient Selection; Practice Guidelines as Topic; Statistics as Topic; Survival Analysis; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome; United States | 2011 |
The PLATO trial reveals further opportunities to improve outcomes in patients with acute coronary syndrome. Editorial on Serebruany. "Viewpoint: Paradoxical excess mortality in the PLATO trial should be independently verified" (Thromb Haemost 2011; 105.5)
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials as Topic; Clinical Trials Data Monitoring Committees; Clopidogrel; Europe; Genetic Predisposition to Disease; Humans; Research Design; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome; United States | 2011 |
Significance of cardiocoronary pathology in acute stroke.
Topics: Aspirin; Clopidogrel; Coronary Disease; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2011 |
Stroke and transient ischemic attack in the long-term care setting: patient characteristics, medication treatment, and length of stay.
Topics: Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Databases, Factual; Drug Administration Schedule; Female; Humans; Ischemic Attack, Transient; Length of Stay; Long-Term Care; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Ticlopidine; Time Factors | 2011 |
Clopidogrel: to test or not to test? That is the question--still.
Topics: Aryl Hydrocarbon Hydroxylases; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Precision Medicine; Ticlopidine; United States; United States Food and Drug Administration | 2011 |
An initial experiment with personalized antiplatelet therapy: the GRAVITAS trial.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Randomized Controlled Trials as Topic; Risk; Thrombosis; Ticlopidine | 2011 |
Antiplatelet and anticoagulation therapy in vitreoretinal surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Case-Control Studies; Child; Clopidogrel; Contraindications; Eye Hemorrhage; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Factors; Ticlopidine; Vitreoretinal Surgery; Warfarin | 2011 |
Effective management of acute coronary thrombosis in a young woman with lupus using aggressive medical therapy.
Topics: Adult; Aspirin; Clopidogrel; Coronary Thrombosis; Eptifibatide; Female; Fibrinolytic Agents; Heparin; Humans; Lupus Erythematosus, Systemic; Peptides; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Impact of combination of calcium-channel blockers with clopidogrel on clinical outcomes in patients with coronary artery disease.
Topics: Aged; Calcium Channel Blockers; Clopidogrel; Cohort Studies; Coronary Artery Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Ticlopidine; Treatment Outcome | 2011 |
Does hemodialysis affect clopidogrel resistance as measured by VerifyNow P2Y12 test?
Topics: Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Drug Resistance; Humans; Kidney Failure, Chronic; Long-Term Care; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Renal Dialysis; Stents; Ticlopidine; Treatment Outcome | 2011 |
Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel, reflecting its negligible potential in P-glycoprotein- and cytochrome P4503A-mediated herb-drug interactions.
Topics: Administration, Oral; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cyclosporine; Cytochrome P-450 CYP3A; Docetaxel; Drugs, Chinese Herbal; Herb-Drug Interactions; Infusions, Intravenous; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Taxoids; Ticlopidine | 2011 |
Cessation of clopidogrel before major abdominal procedures.
Topics: Abdomen; Aged; Analysis of Variance; Blood Loss, Surgical; Clopidogrel; Cohort Studies; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Humans; Male; Multivariate Analysis; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Risk Assessment; Surgical Procedures, Operative; Survival Rate; Ticlopidine; Time Factors; Withholding Treatment | 2011 |
[Simultaneous transcatheter treatment of perimembranous ventricular septal defect and secundum atrial septal defect in an adult: first application in Turkey].
Topics: Anesthetics, Intravenous; Clopidogrel; Echocardiography, Transesophageal; Female; Fluoroscopy; Heart Septal Defects, Atrial; Heart Septal Defects, Ventricular; Humans; Midazolam; Platelet Aggregation Inhibitors; Septal Occluder Device; Ticlopidine; Turkey; Young Adult | 2011 |
Optimal timing of anticoagulation pre- and post-colonoscopy with polypectomy.
Topics: Anticoagulants; Aspirin; Clopidogrel; Colonic Polyps; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Postoperative Period; Retrospective Studies; Ticlopidine; Warfarin | 2011 |
Very late thrombosis of flow-diverting constructs after the treatment of large fusiform posterior circulation aneurysms.
Topics: Adult; Cerebral Angiography; Cerebral Revascularization; Cerebrovascular Circulation; Clopidogrel; Fatal Outcome; Female; Humans; Intracranial Aneurysm; Male; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombectomy; Thrombosis; Ticlopidine; Time Factors | 2011 |
High residual platelet reactivity on standard clopidogrel maintenance dose predicts increased responsiveness to the double-standard dose in an assay-dependent manner.
Topics: Adenosine Monophosphate; Aged; Angioplasty; Clinical Protocols; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Function Tests; Predictive Value of Tests; Reproducibility of Results; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2011 |
Peri-operative management of antiplatelet therapy in patients with coronary artery disease: joint position paper by members of the working group on Perioperative Haemostasis of the Society on Thrombosis and Haemostasis Research (GTH), the working group on
Topics: Aspirin; Blood Loss, Surgical; Cardiovascular Surgical Procedures; Clopidogrel; Contraindications; Coronary Artery Disease; Drug-Eluting Stents; Evidence-Based Medicine; Hemostasis, Surgical; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Precision Medicine; Ticlopidine | 2011 |
Incidence of death and recurring acute coronary syndrome after stopping clopidogrel therapy in a large commercially-insured population in the US.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Humans; Incidence; Insurance Coverage; Insurance, Health; Male; Middle Aged; Platelet Aggregation Inhibitors; Poisson Distribution; Retrospective Studies; Ticlopidine; United States | 2011 |
Acute upper gastrointestinal hemorrhage in an elderly woman taking aspirin and clopidogrel.
Topics: Aged; Aspirin; Clopidogrel; Female; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
A case of subacute thrombosis associated with clopidogrel resistance after implantation of a zotarolimus-eluting stent.
Topics: Aged; Angioplasty, Balloon, Coronary; Anterior Wall Myocardial Infarction; Aryl Hydrocarbon Hydroxylases; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Resistance; Drug-Eluting Stents; Female; Genotype; Humans; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prosthesis Design; Sirolimus; Thrombectomy; Thrombosis; Ticlopidine; Treatment Outcome; Ultrasonography, Interventional | 2012 |
Influence of updated guidelines on short- and long-term mortality in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS).
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angina, Unstable; Clopidogrel; Female; Follow-Up Studies; Hospital Mortality; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Practice Guidelines as Topic; Retrospective Studies; Survival Rate; Ticlopidine; Treatment Outcome | 2012 |
Protect your heart during dental work. Don't stop taking aspirin, Plavix, or any other antiplatelet before dental work without asking your cardiologist.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Dental Care for Chronically Ill; Heart Diseases; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
The rate of post-polypectomy bleeding for patients on uninterrupted clopidogrel therapy during elective colonoscopy is acceptably low.
Topics: Case-Control Studies; Clopidogrel; Colonic Polyps; Colonoscopy; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2011 |
Formulation of tablets containing an 'in-process' amorphized active pharmaceutical ingredient.
Topics: Chemistry, Pharmaceutical; Clopidogrel; Crystallization; Pharmaceutical Preparations; Tablets; Technology, Pharmaceutical; Ticlopidine | 2011 |
Use of the oral platelet inhibitors dipyridamole and acetylsalicylic acid is associated with increased risk of fracture.
Topics: Acute Coronary Syndrome; Adult; Aged; Aspirin; Case-Control Studies; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Fractures, Bone; Humans; Male; Middle Aged; Osteoporosis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2012 |
Atrial fibrillation, is warfarin the only option for stroke prevention?
Topics: Angiotensin II Type 1 Receptor Blockers; Anticoagulants; Atrial Fibrillation; Biphenyl Compounds; Clinical Trials as Topic; Clopidogrel; Evidence-Based Medicine; Humans; Irbesartan; Platelet Aggregation Inhibitors; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome; Warfarin | 2011 |
Atrial fibrillation, is warfarin the only option for stroke prevention?
Topics: Angiotensin II Type 1 Receptor Blockers; Anticoagulants; Aspirin; Atrial Fibrillation; Biphenyl Compounds; Cerebral Hemorrhage; Clopidogrel; Evidence-Based Medicine; Follow-Up Studies; Humans; Hypertension; Irbesartan; Platelet Aggregation Inhibitors; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome; Warfarin | 2011 |
Clopidogrel resistance and the effect of combination cilostazol in patients with ischemic stroke or carotid artery stenting using the VerifyNow P2Y12 Assay.
Topics: Aged; Blood Coagulation Tests; Blood Platelets; Carotid Artery Diseases; Cilostazol; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Secondary Prevention; Stents; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome | 2011 |
Can endoscopists become more aggressive or have more options for patients with antithrombotic agents?
Topics: Clopidogrel; Colonic Polyps; Colonoscopy; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
[Do genetic factors reduce the effects of clopidogrel?].
Topics: Adenosine; Clopidogrel; Cytochrome P-450 Enzyme System; Genetic Variation; Genotype; Hemorrhage; Humans; Isoenzymes; Pharmacogenetics; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
Temporal trends and practice variations in clopidogrel loading doses in patients with non-ST-segment elevation myocardial infarction, from the National Cardiovascular Data Registry.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Registries; Retrospective Studies; Ticlopidine; Treatment Outcome | 2011 |
Clinical, pharmacokinetic, and pharmacogenetic determinants of clopidogrel resistance in Korean patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Diabetes Complications; Drug Resistance; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Republic of Korea; Ticlopidine | 2011 |
Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury.
Topics: Animals; Apolipoproteins E; Blood Platelets; Carotid Arteries; Clopidogrel; Coronary Thrombosis; Disease Models, Animal; High-Energy Shock Waves; Humans; Immunohistochemistry; Mice; Mice, Knockout; Plaque, Atherosclerotic; Platelet Activation; Ticlopidine | 2011 |
Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability between 2 and 6 weeks post cessation.
Topics: Aged; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Stents; Thrombosis; Ticlopidine; Time Factors | 2011 |
Intra-individual variability of residual platelet reactivity assessed by the VerifyNow-P2Y12 assay in patients with clopidogrel resistance after percutaneous coronary intervention.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2011 |
Esomeprazole but not pantoprazole is associated with lower plasma concentrations of clopidogrel's active metabolite.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Clopidogrel; Drug Interactions; Enzyme Inhibitors; Esomeprazole; Female; Humans; Male; Middle Aged; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
[Antiplatelet therapy in acute coronary syndromes: state of the art and new perspectives].
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Left main stent thrombosis complicated by eptifibatide-induced acute thrombocytopenia.
Topics: Acute Disease; Angioplasty, Balloon, Coronary; Aspirin; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Electrocardiography; Eptifibatide; Heparin; Humans; Male; Middle Aged; Peptides; Platelet Aggregation Inhibitors; Platelet Count; Stents; Thrombectomy; Thrombocytopenia; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
The P-selectin gene Pro715 allele and low levels of soluble P-selectin are associated with reduced P2Y12 adenosine diphosphate receptor reactivity in clopidogrel-treated patients.
Topics: Adult; Alleles; Angioplasty; Clopidogrel; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proline; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2011 |
[Multiple arterial thrombosis and resistance to conventional antiaggregation].
Topics: Aged; Angiography; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Resistance; Electrocardiography; Female; Femoral Artery; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2011 |
High plasma interleukin-6 is associated with drug-eluting stent thrombosis: possible role of inflammatory cytokines in the development of stent thrombosis from the Korea Stent Thrombosis Registry.
Topics: Aged; Angioplasty, Balloon, Coronary; Biomarkers; Case-Control Studies; Chemokine CCL2; Chi-Square Distribution; Clopidogrel; Drug-Eluting Stents; Female; Humans; Inflammation Mediators; Interleukin-6; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Design; Registries; Republic of Korea; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
A 23-year patency of a saphenous vein graft in a patient with diabetes mellitus.
Topics: Aged; Angina Pectoris; Clopidogrel; Coronary Artery Bypass; Diabetes Mellitus, Type 2; Humans; Male; Platelet Aggregation Inhibitors; Saphenous Vein; Ticlopidine; Time Factors | 2011 |
Age-related differences in antithrombotic therapy, success rate and in-hospital mortality in patients undergoing percutaneous coronary intervention: results of the quality control registry of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzt
Topics: Acute Coronary Syndrome; Age Factors; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Comorbidity; Female; Fibrinolytic Agents; Germany; Hospital Mortality; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Registries; Ticlopidine; Treatment Outcome | 2011 |
Optimizing platelet inhibition in clopidogrel poor metabolizers: therapeutic options and practical considerations.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Drug Therapy, Combination; Genotype; Humans; Myocardial Ischemia; Patient Selection; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2011 |
[Preoperative analysis of platelet aggregability in carotid surgery].
Topics: Aged; Aged, 80 and over; Aspirin; Carotid Arteries; Clopidogrel; Endarterectomy, Carotid; Female; Humans; Intraoperative Complications; Ischemia; Male; Middle Aged; Perioperative Period; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Stents; Ticlopidine | 2011 |
Complications of cutaneous surgery in patients taking clopidogrel-containing anticoagulation.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Dermatologic Surgical Procedures; Female; Humans; Male; Middle Aged; Mohs Surgery; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Ticlopidine; Warfarin | 2011 |
A postal survey of UK practice on discontinuation of anticoagulant/antithrombotics therapy before minor cutaneous surgery of the head and neck.
Topics: Ambulatory Surgical Procedures; Anticoagulants; Aspirin; Cervicoplasty; Clopidogrel; Drug Administration Schedule; Fibrinolytic Agents; Humans; Practice Patterns, Physicians'; Preoperative Care; Surveys and Questionnaires; Ticlopidine; United Kingdom; Warfarin | 2011 |
How do we manage patients treated with antithrombotic therapy in the perioperative interval.
Topics: Anticoagulants; Antifibrinolytic Agents; Antithrombins; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coagulants; Factor Xa Inhibitors; Fibrinolytic Agents; Hemostasis, Surgical; Heparin; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Assessment; Ticlopidine; Vitamin K; Warfarin | 2011 |
Efficacy and safety of clopidogrel after PCI with stenting in patients on oral anticoagulants with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Care Units; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Registries; Risk Assessment; Risk Factors; Stents; Sweden; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Relation between clopidogrel discontinuation and early cardiovascular events after percutaneous coronary intervention with drug-eluting stents.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; District of Columbia; Drug Administration Schedule; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prosthesis Design; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Wound Healing | 2011 |
Dual antiplatelet therapy and the risk of bleeding.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Warfarin | 2011 |
[Does combination therapy of aspirin plus antiplatelet therapy increase the risk of upper gastrointestinal hemorrhage?].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Endoscopy, Gastrointestinal; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2011 |
[The effect of aspirin alone or aspirin plus additional antiplatelets therapy on upper gastrointestinal hemorrhage].
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Endoscopy, Gastrointestinal; Female; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Peptic Ulcer; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2011 |
Charting a path for Plavix response testing.
Topics: Clopidogrel; Drug Labeling; Genetic Testing; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; United States; United States Food and Drug Administration | 2011 |
Impaired inhibition of P2Y(12) by clopidogrel is a major determinant of cardiac death in diabetes mellitus patients treated by percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Drug Resistance; Female; Flow Cytometry; France; Heart Diseases; Humans; Kaplan-Meier Estimate; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proportional Hazards Models; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
[ACC/AHA warning on effectiveness of clopidogrel].
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Resistance; Genetic Testing; Humans; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2010 |
The use of contrast echo to clear the left atrial appendage.
Topics: Aspirin; Atrial Appendage; Clopidogrel; Contrast Media; Drug Therapy, Combination; Echocardiography; Echocardiography, Transesophageal; Fluorocarbons; Heart Atria; Heart Diseases; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2011 |
No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Aspirin; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Graft Occlusion, Vascular; Heterozygote; Homozygote; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Stents; Ticlopidine | 2011 |
Gastrointestinal bleeding and outcomes after percutaneous coronary intervention for ST-segment elevation myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Female; Gastrointestinal Hemorrhage; Heparin; Hospital Mortality; Humans; Length of Stay; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Taiwan; Ticlopidine; Treatment Outcome | 2011 |
Stent thrombosis after drug eluting stent implantation.
Topics: Angioplasty, Balloon, Coronary; Biomarkers; Chemokine CCL2; Clopidogrel; Drug-Eluting Stents; Humans; Inflammation Mediators; Interleukin-6; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Comparison of the VASP assay and platelet aggregometry in the evaluation of platelet P2Y12 receptor blockade.
Topics: Adenosine Monophosphate; Adult; Aged; Cell Adhesion Molecules; Clopidogrel; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Function Tests; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2011 |
Optimizing of thienopyridine therapy by multiple electrode platelet aggregometry in clopidogrel low responders undergoing PCI.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Cerebrovascular Disorders; Cilostazol; Clopidogrel; Drug Monitoring; Drug Resistance; Drug Substitution; Electrodes; Female; Germany; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Stents; Tetrazoles; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Simultaneous drug-eluting and bare-metal stent implantation: long-term clinical outcome and findings of clinically indicated coronary angiography.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Confidence Intervals; Coronary Angiography; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Multivariate Analysis; Paclitaxel; Platelet Aggregation Inhibitors; Prospective Studies; Statistics as Topic; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Proton pump inhibitor and clopidogrel interaction: have we forgotten aspirin?
Topics: Aspirin; Clopidogrel; Drug Interactions; Humans; Kinetics; Proton Pump Inhibitors; Ticlopidine | 2011 |
The unmet need of patients with atrial fibrillation: AVERROES and the novel oral anticoagulants.
Topics: Angiotensin II Type 1 Receptor Blockers; Anticoagulants; Aspirin; Atrial Fibrillation; Biphenyl Compounds; Clinical Trials, Phase III as Topic; Clopidogrel; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; Intracranial Hemorrhages; Irbesartan; Platelet Aggregation Inhibitors; Pyrazoles; Pyridones; Stroke; Tetrazoles; Ticlopidine | 2011 |
[The CURRENT-OASIS 7 study].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Confidence Intervals; Drug Administration Schedule; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proportional Hazards Models; Randomized Controlled Trials as Topic; Salivary Ducts; Thrombosis; Ticlopidine | 2011 |
[Tailored treatment with clopidogrel based on the results of platelet function tests should not be implemented, in the absence of clear indications on the methodology to be used].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Drug Resistance; Evidence-Based Medicine; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Precision Medicine; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2011 |
Randomized trial of aspirin and clopidogrel versus aspirin alone for the prevention of coronary artery bypass graft occlusion: the preoperative aspirin and postoperative antiplatelets in coronary artery bypass grafting surgery.
Topics: Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Drug Therapy, Combination; Graft Occlusion, Vascular; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Postoperative Care; Preoperative Care; Randomized Controlled Trials as Topic; Ticlopidine | 2011 |
Clopidogrel is not associated with major bleeding complications during peripheral arterial surgery.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Aspirin; Blood Transfusion; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; New England; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Registries; Reoperation; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Vascular Surgical Procedures | 2011 |
Regarding "results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial".
Topics: Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Drug Therapy, Combination; Graft Occlusion, Vascular; Humans; Peripheral Arterial Disease; Placebo Effect; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome; Veins | 2011 |
Feasibility and safety of 7-Fr radial approach for complex PCI.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Stenosis; Feasibility Studies; Female; Femoral Artery; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Radial Artery; Retrospective Studies; Ticlopidine; Ultrasonography, Interventional | 2011 |
High on treatment platelet reactivity and stent thrombosis.
Topics: Adult; Aged; Angioplasty; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2011 |
Effect of early clopidogrel discontinuation on rehospitalization in acute coronary syndrome: results from two distinct patient populations.
Topics: Acute Coronary Syndrome; Adolescent; Adult; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Databases, Factual; Female; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2011 |
[Amorphous form in pharmaceutical technological research].
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chlorhexidine; Clopidogrel; Dihydropyridines; Gemfibrozil; Glass; Ibuprofen; Loratadine; Meloxicam; Pharmaceutical Preparations; Piroxicam; Sorbitol; Technology, Pharmaceutical; Thiazines; Thiazoles; Ticlopidine | 2011 |
The impact of noncardiac surgery on selection of a revascularization strategy.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Humans; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Assessment; Risk Factors; Surgical Procedures, Operative; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Fluoxetine and motor recovery after ischaemic stroke.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Fluoxetine; Humans; Motor Skills; Platelet Aggregation Inhibitors; Recovery of Function; Selective Serotonin Reuptake Inhibitors; Stroke; Stroke Rehabilitation; Ticlopidine; Treatment Outcome; Vascular Endothelial Growth Factor A | 2011 |
Fluoxetine and motor recovery after ischaemic stroke.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Fluoxetine; Humans; Motor Skills; Platelet Aggregation Inhibitors; Recovery of Function; Selective Serotonin Reuptake Inhibitors; Stroke; Stroke Rehabilitation; Ticlopidine; Treatment Outcome; Vascular Endothelial Growth Factor A | 2011 |
Relationship between plasma inflammatory markers and platelet aggregation in patients with clopidogrel resistance after angioplasty.
Topics: Acute Coronary Syndrome; Adult; Angioplasty, Balloon, Coronary; Blood Vessel Prosthesis Implantation; C-Reactive Protein; CD40 Ligand; Clopidogrel; Drug Resistance; Female; Humans; Interleukin-6; Male; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors | 2012 |
Predictors of intracranial hemorrhage in patients taking anticoagulant and antiplatelet medication.
Topics: Anticoagulants; Clopidogrel; Craniocerebral Trauma; Glasgow Coma Scale; Humans; International Normalized Ratio; Intracranial Hemorrhage, Traumatic; Partial Thromboplastin Time; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Tomography, X-Ray Computed; Warfarin | 2011 |
Clopidogrel response variability and its correlation with early recurrent cardiovascular events in chinese patients undergoing percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Asian People; Cardiovascular Diseases; Clopidogrel; Female; Humans; Individuality; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Stents; Ticlopidine; Treatment Outcome | 2011 |
Multiple electrode aggregometry and vasodilator stimulated phosphoprotein-phosphorylation assay in clinical routine for prediction of postprocedural major adverse cardiovascular events.
Topics: Acute Coronary Syndrome; Adult; Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Risk Factors; ROC Curve; Stents; Ticlopidine | 2011 |
The influencing factors for clopidogrel-mediated platelet inhibition are assay-dependent.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Austria; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Drug Therapy, Combination; Female; Humans; Linear Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Purinergic P2Y12; Reproducibility of Results; Risk Assessment; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2011 |
Diurnal variation in platelet inhibition by clopidogrel.
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Circadian Rhythm; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
[Factors determining clinical effectiveness of clopidogrel and prognosis of patients with stable ischemic heart disease].
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Female; Follow-Up Studies; Gene Frequency; Genetic Predisposition to Disease; Humans; Liver; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Treatment Outcome | 2011 |
Clopidogrel protects from cell apoptosis and oxidative damage in a mouse model of renal ischaemia-reperfusion injury.
Topics: Animals; Apoptosis; Clopidogrel; Disease Models, Animal; Fluorescent Antibody Technique; Immunoblotting; In Situ Nick-End Labeling; Kidney; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Purinergic P2Y Receptor Antagonists; Reperfusion Injury; Ticlopidine | 2011 |
Effect of clopidogrel pretreatment on ischemic complications of percutaneous coronary intervention among bivalirudin-treated patients (from the EVENT registry).
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Antithrombins; Clopidogrel; Female; Hemorrhage; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Platelet Aggregation Inhibitors; Premedication; Recombinant Proteins; Thrombosis; Ticlopidine | 2011 |
Safety and efficacy of clopidogrel reloading in patients on chronic clopidogrel therapy who present with an acute coronary syndrome and undergo percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2011 |
Clopidogrel loading dose in patients undergoing elective percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Clopidogrel-associated acute generalized exanthematous pustulosis.
Topics: Acute Generalized Exanthematous Pustulosis; Aged, 80 and over; Clopidogrel; Diagnosis, Differential; Drug Eruptions; Female; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
New clopidogrel napadisilate salt and its solid dispersion with improved stability and bioequivalence to the commercial clopidogrel bisulphate salt in beagle dogs.
Topics: Administration, Oral; Animals; Biological Availability; Chromatography, High Pressure Liquid; Clopidogrel; Crystallization; Dogs; Drug Compounding; Drug Stability; Male; Molecular Structure; Platelet Aggregation Inhibitors; Powder Diffraction; Solubility; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Ticlopidine; X-Ray Diffraction | 2011 |
Prasugrel as a safe alternative for clopidogrel-associated arthritis.
Topics: Arthritis; Clopidogrel; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2011 |
Early determination of clopidogrel responsiveness by platelet reactivity indexidentifies patients at risk for cardiovascular events after myocardial infarction.
Topics: Aged; Clopidogrel; Disease Progression; Drug Resistance; Early Diagnosis; Female; Flow Cytometry; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Function Tests; Predictive Value of Tests; Prognosis; Receptors, Purinergic P2Y12; Reference Values; Ticlopidine; Treatment Outcome | 2011 |
Development and validation of an HPLC-MS/MS method to quantify clopidogrel acyl glucuronide, clopidogrel acid metabolite, and clopidogrel in plasma samples avoiding analyte back-conversion.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Clopidogrel; Humans; Reproducibility of Results; Tandem Mass Spectrometry; Ticlopidine | 2011 |
[Usefulness of the Tornus® catheter in nondilatable coronary chronic total occlusion].
Topics: Aged; Cardiac Catheterization; Catheterization; Catheters; Clopidogrel; Coronary Angiography; Coronary Occlusion; Female; Humans; Male; Middle Aged; Myocardial Revascularization; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Failure | 2011 |
Gastroesophageal reflux disease: endoscopy, duration of treatment, and choice of PPI.
Topics: Adenocarcinoma; Clopidogrel; Drug Industry; Drug Interactions; Endoscopy, Gastrointestinal; Esophageal Neoplasms; Gastroesophageal Reflux; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Research Support as Topic; Ticlopidine | 2011 |
Results with Viabahn-assisted subintimal recanalization for TASC C and TASC D superficial femoral artery occlusive disease.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Ankle Brachial Index; Anticoagulants; Arterial Occlusive Diseases; Aspirin; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Chi-Square Distribution; Clopidogrel; Endovascular Procedures; Female; Femoral Artery; Humans; Illinois; Male; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Design; Reoperation; Severity of Illness Index; Stents; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Duplex; Vascular Patency; Warfarin | 2011 |
Recurrent ischemic stroke in a patient with ulcerative colitis and high levels of lipoprotein (a).
Topics: Anticholesteremic Agents; Anticoagulants; Aspirin; Atorvastatin; Blood Coagulation Tests; Carotid Stenosis; Clopidogrel; Colitis, Ulcerative; Female; Heparin, Low-Molecular-Weight; Heptanoic Acids; Humans; Lipoprotein(a); Magnetic Resonance Imaging; Middle Aged; Pyrroles; Risk Factors; Stroke; Thrombosis; Ticlopidine; Ultrasonography | 2011 |
Effects of platelet and inflammatory system activation on outcomes in diabetic patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Restenosis; Diabetes Complications; Electrocardiography; Female; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
[Clinical significance of interactions between clopidogrel and proton pump inhibitors].
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Prospective evaluation of on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary intervention relationship with gene polymorphisms and clinical outcome.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Genotype; Humans; Myocardial Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Unraveling myths of platelet function and genetic testing the road to making tailored antiplatelet therapy a reality.
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Assessment; Risk Factors; Ticlopidine | 2011 |
[Intracerebral hemorrhage in anticoagulated patients: what do we do afterwards?].
Topics: Aged; Anticoagulants; Aspirin; Cerebral Hemorrhage; Clopidogrel; Female; Follow-Up Studies; Humans; Intracranial Embolism; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Risk; Risk Factors; Stroke; Ticlopidine; Vitamin K | 2012 |
Risk assessment of simple phacoemulsification in patients on combined anticoagulant and antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Drug Therapy, Combination; Eye Hemorrhage; Female; Humans; Intraoperative Complications; Lens Implantation, Intraocular; Male; Middle Aged; Phacoemulsification; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Prothrombin Time; Risk Assessment; Thromboembolism; Ticlopidine; Warfarin | 2011 |
Comparison of drug-eluting versus bare metal stents in cardiac allograft vasculopathy.
Topics: Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Coronary Disease; Drug-Eluting Stents; Female; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Metals; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Sirolimus; Stents; Ticlopidine; Transplantation, Homologous; Treatment Outcome; Tubulin Modulators | 2011 |
Predictors of neck bleeding after eversion carotid endarterectomy.
Topics: Adult; Aged; Aged, 80 and over; Carotid Artery Diseases; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Endarterectomy, Carotid; Female; Hospitals, University; Humans; Hypertension; Italy; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Registries; Reoperation; Retrospective Studies; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Non-interventional management of acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2011 |
Oral antiplatelet agents clopidogrel and prasugrel for the prevention of cardiovascular events.
Topics: Administration, Oral; Cardiovascular Diseases; Clopidogrel; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2011 |
Beneficial effect of anti-platelet therapies on atherosclerotic lesion formation assessed by phase-contrast X-ray CT imaging.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Body Weight; Brachiocephalic Trunk; Cell Adhesion Molecules; Cholesterol, Dietary; Cilostazol; Clopidogrel; Collagen; Cytokines; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Inflammation Mediators; Lipids; Macrophages; Mice; Mice, Knockout; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Ticlopidine; Tomography, X-Ray Computed | 2012 |
Coadministration of clopidogrel and proton pump inhibitors.
Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Standard- vs high-dose clopidogrel after percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Hemorrhage; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Reproducibility of Results; Risk; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Standard- vs high-dose clopidogrel after percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Humans; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Reproducibility of Results; Risk; Ticlopidine | 2011 |
Percutaneous coronary intervention of unprotected left main coronary artery disease as culprit lesion in patients with acute myocardial infarction.
Topics: Aged; Angioplasty; Bundle-Branch Block; Clopidogrel; Confidence Intervals; Coronary Artery Disease; Coronary Vessels; Emergency Medical Services; Female; Health Status Indicators; Hemodynamics; Hospital Mortality; Humans; Italy; Logistic Models; Male; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Shock, Cardiogenic; Ticlopidine; Treatment Outcome | 2011 |
The prevalence of co-administration of clopidogrel and proton pump inhibitors.
Topics: Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Drug Utilization Review; Female; Gastrointestinal Hemorrhage; Humans; Male; New South Wales; Nursing Homes; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2011 |
Pharmacokinetics of ferulic acid and potential interactions with Honghua and clopidogrel in rats.
Topics: Administration, Oral; Animals; Biological Availability; Cardiovascular Agents; Carthamus tinctorius; Clopidogrel; Coumaric Acids; Drugs, Chinese Herbal; Herb-Drug Interactions; Intestinal Absorption; Male; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ticlopidine | 2011 |
Bleeding after percutaneous endoscopic gastrostomy is linked to serotonin reuptake inhibitors, not aspirin or clopidogrel.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cohort Studies; Female; Gastrointestinal Hemorrhage; Gastroscopy; Gastrostomy; Humans; Male; Middle Aged; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Ticlopidine; Time Factors; Young Adult | 2011 |
Wireless pulmonary artery haemodynamic monitoring.
Topics: Anticoagulants; Aspirin; Clopidogrel; Electrodes, Implanted; Equipment Design; Female; Heart Failure; Hemodynamics; Humans; Male; Microchip Analytical Procedures; Monitoring, Physiologic; Pulmonary Artery; Pulmonary Wedge Pressure; Sensitivity and Specificity; Survival Analysis; Ticlopidine; Warfarin | 2011 |
A complex case of angulated and bifurcated lesion facilitated by excimer laser coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Stenosis; Humans; Lasers, Excimer; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Detection of clopidogrel hyporesponsiveness using a point-of-care assay and the impact of additional cilostazol administration after coronary stent implantation in diabetic patients.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Chi-Square Distribution; Cilostazol; Clopidogrel; Coronary Disease; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Registries; Republic of Korea; Risk Assessment; Risk Factors; Stents; Tetrazoles; Ticlopidine; Treatment Outcome | 2011 |
[Specificities of diabetes in acute coronary syndromes].
Topics: Acute Coronary Syndrome; Algorithms; Angioplasty; Anti-Inflammatory Agents, Non-Steroidal; Clopidogrel; Diabetes Complications; Diabetes Mellitus; Drug Therapy, Combination; Enoxaparin; Evidence-Based Medicine; Fibrinolytic Agents; Heparin; Humans; Hypoglycemic Agents; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Risk Factors; Secondary Prevention; Stents; Thiophenes; Ticlopidine; Treatment Outcome | 2011 |
Endothelium-independent vasorelaxation by ticlopidine and clopidogrel in rat caudal artery.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arteries; Cell Proliferation; Clopidogrel; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Ticlopidine; Vasoconstriction; Vasodilator Agents | 2011 |
Effect of upstream clopidogrel treatment in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Propensity Score; Shock, Cardiogenic; Stents; Ticlopidine; Treatment Outcome | 2011 |
Subacute stent thrombosis owing to complete clopidogrel resistance successfully managed with prasugrel.
Topics: Angioplasty, Balloon, Coronary; Anterior Wall Myocardial Infarction; Clopidogrel; Contraindications; Coronary Artery Disease; Drug Resistance; Drug-Eluting Stents; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Thiophenes; Thrombosis; Ticlopidine; Treatment Failure; Treatment Outcome | 2011 |
Massive thrombus burden with recurrence of intracoronary thrombosis early after stenting and delayed onset of prasugrel action in a patient with ST-elevation myocardial infarction and cardiac shock.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiopulmonary Resuscitation; Catecholamines; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Interactions; Electrocardiography; Female; Heart Arrest; Humans; Myocardial Infarction; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Recurrence; Stents; Thiophenes; Ticlopidine; Time Factors | 2011 |
Comparison of efficacy and safety of a standard versus a loading dose of clopidogrel for acute myocardial infarction in patients ≥ 75 years of age (from the FAST-MI registry).
Topics: Aged; Aged, 80 and over; Analysis of Variance; Blood Transfusion; Clopidogrel; Female; France; Hemorrhage; Hospital Mortality; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Registries; Risk Factors; Survival Rate; Ticlopidine; Treatment Outcome | 2011 |
A clopidogrel-insensitive inducible pool of P2Y12 receptors contributes to thrombus formation: inhibition by elinogrel, a direct-acting, reversible P2Y12 antagonist.
Topics: Animals; Clopidogrel; Cyclic AMP; Fibrinolytic Agents; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Quinazolinones; Radioligand Assay; Receptors, Purinergic P2Y12; Sulfonamides; Thrombosis; Ticlopidine | 2011 |
Drug regulatory agencies' role in the interaction between clopidogrel and proton pump inhibitors.
Topics: Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Ticlopidine; United States; United States Food and Drug Administration | 2011 |
Late bare-metal stent thrombosis in a patient with Crohn's disease.
Topics: Adult; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Crohn Disease; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2011 |
Reduced antiplatelet therapy after drug-eluting stenting: multicenter Janus Flex carbostent implantation with short dual antiplatelet treatment for 2 or 6 months-MATRIX study.
Topics: Aged; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hospitals, High-Volume; Humans; Italy; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Registries; Risk Assessment; Risk Factors; Tacrolimus; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Predictors of low clopidogrel adherence following percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Disease; Female; Humans; Male; Medication Adherence; Middle Aged; New York; Platelet Aggregation Inhibitors; Predictive Value of Tests; Risk Factors; Surveys and Questionnaires; Texas; Ticlopidine; Treatment Outcome | 2011 |
Standard versus high loading doses of clopidogrel in Asian patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: insights from the Korea Acute Myocardial Infarction Registry.
Topics: Angioplasty, Balloon, Coronary; Asian People; Clopidogrel; Dose-Response Relationship, Drug; Electrocardiography; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Registries; Republic of Korea; Ticlopidine; Treatment Outcome | 2011 |
Effects of an anti-platelet drug on the prevention of steroid-induced osteonecrosis in rabbits.
Topics: Animals; Clopidogrel; Femur; Glucocorticoids; Humerus; Male; Methylprednisolone; Osteonecrosis; Platelet Aggregation Inhibitors; Rabbits; Ticlopidine | 2012 |
PCI and clopidogrel: antiplatelet responsiveness and patient characteristics.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Thrombosis; Ticlopidine | 2011 |
Have medical therapy and stenting been fairly compared? A repercussion upon termination of recruitment in the SAMMPRIS trial.
Topics: Angioplasty; Aspirin; Carotid Stenosis; Clinical Trials as Topic; Clopidogrel; Humans; National Institute of Neurological Disorders and Stroke (U.S.); Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine; United States | 2011 |
Atorvastatin and clopidogrel interfere with photosensitization in vitro.
Topics: Animals; Anticholesteremic Agents; Aspirin; Atorvastatin; Cathepsin B; Cell Line; Clopidogrel; Heptanoic Acids; Humans; Light; Macrophages; Mice; Neoplasms; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Polylysine; Porphyrins; Pyrroles; Ticlopidine | 2011 |
Relation of body mass index to on-treatment (clopidogrel + aspirin) platelet reactivity.
Topics: Adenosine Diphosphate; Aspirin; Body Mass Index; Cell Adhesion Molecules; Clopidogrel; Coronary Disease; Female; Humans; Logistic Models; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Function Tests; Risk Factors; Statistics, Nonparametric; Ticlopidine | 2011 |
Silent myocardial infarction subsequent to cutaneous polyarteritis nodosa in a patient with positive lupus anticoagulant.
Topics: Aged; Anterior Wall Myocardial Infarction; Biopsy, Needle; Clopidogrel; Follow-Up Studies; Humans; Immunohistochemistry; Lupus Coagulation Inhibitor; Male; Platelet Aggregation Inhibitors; Polyarteritis Nodosa; Risk Assessment; Skin Diseases; Ticlopidine; Treatment Outcome; Warfarin | 2011 |
Right hemiparesis in right carotid stenosis.
Topics: Aged; Anticholesteremic Agents; Atherectomy; Atorvastatin; Carotid Stenosis; Clopidogrel; Combined Modality Therapy; Diffusion Magnetic Resonance Imaging; Heptanoic Acids; Humans; Male; Paresis; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine; Treatment Outcome; Ultrasonography | 2011 |
Clopidogrel use throughout pregnancy in a patient with a drug-eluting coronary stent.
Topics: Adult; Cesarean Section; Clopidogrel; Cocaine; Drug-Eluting Stents; Female; Humans; Infant, Newborn; Myocardial Infarction; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Hematologic; Ticlopidine; Treatment Outcome | 2011 |
[Clopidogrel and proton pump inhibitors: insufficient evidence of interaction].
Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Drug Interactions; Gastrointestinal Diseases; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Prospective evaluation of dermatologic surgery complications including patients on multiple antiplatelet and anticoagulant medications.
Topics: Aged; Ambulatory Surgical Procedures; Antibiotic Prophylaxis; Anticoagulants; Clopidogrel; Dermatologic Surgical Procedures; Female; Humans; Male; Mohs Surgery; Necrosis; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Surgical Flaps; Surgical Wound Infection; Ticlopidine; Warfarin | 2011 |
Dose-related effect of statins in venous thrombosis risk reduction.
Topics: Aged; Aspirin; Atherosclerosis; Cerebral Infarction; Clopidogrel; Cohort Studies; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Pulmonary Embolism; Retrospective Studies; Risk Reduction Behavior; Ticlopidine; Venous Thromboembolism | 2011 |
Impact of adjunctive cilostazol therapy versus high maintenance dose of clopidogrel in suboptimal responders with diabetes mellitus.
Topics: Aspirin; Blood Coagulation; Blood Platelets; Cilostazol; Clopidogrel; Diabetes Mellitus, Type 2; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Tetrazoles; Thrombosis; Ticlopidine | 2012 |
Safety of dental extractions during uninterrupted single or dual antiplatelet treatment.
Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Greece; Hemostatics; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Ticlopidine; Time Factors; Tooth Extraction | 2011 |
Cytochrome P450 2C19 polymorphism is associated with reduced clopidogrel response in cerebrovascular disease.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Retrospective Studies; Ticlopidine | 2011 |
Commentary: recombinant activated factor VII: the controversial conundrum regarding its off-label use.
Topics: Clopidogrel; Factor VIIa; Hemorrhage; Hemostasis; Hemostatics; Humans; Male; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine | 2011 |
Non-cardiac surgery in patients with coronary stents: the RECO study.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; France; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Risk Assessment; Risk Factors; Stents; Surgical Procedures, Operative; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Influence of low-dose aspirin (81 mg) on the incidence of definite stent thrombosis in patients receiving bare-metal and drug-eluting stents.
Topics: Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Sirolimus; Statistics as Topic; Ticlopidine | 2011 |
Involvement of circulating platelets on the hyperalgesic response evoked by carrageenan and Bothrops jararaca snake venom.
Topics: Animals; Aspirin; Blood Platelets; Bothrops; Busulfan; Carrageenan; Clopidogrel; Crotalid Venoms; Cyclooxygenase 1; Hyperalgesia; Male; Rats; Rats, Wistar; Thrombocytopenia; Ticlopidine | 2011 |
Early aggressive medical management for patients with symptomatic intracranial stenosis.
Topics: Aged; Antihypertensive Agents; Aspirin; Biomarkers; Blood Pressure; Body Mass Index; Cerebral Angiography; Chi-Square Distribution; Clopidogrel; Combined Modality Therapy; Constriction, Pathologic; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Arteriosclerosis; Lipoproteins, LDL; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Risk Reduction Behavior; Smoking Cessation; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Weight Loss | 2013 |
The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Interactions; Enzyme Inhibitors; Esomeprazole; Hepatocytes; Humans; Inhibitory Concentration 50; Lansoprazole; Microsomes; Microsomes, Liver; Omeprazole; Pantoprazole; Protein Binding; Proton Pump Inhibitors; Recombinant Proteins; Ticlopidine | 2011 |
Dual oral antiplatelet therapy and unplanned surgery: possible role for intravenous platelet glycoprotein receptor inhibitors.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Aspirin; Biliary Tract Surgical Procedures; Cardiovascular Diseases; Cholangitis; Choledocholithiasis; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Humans; Infusions, Intravenous; Male; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2011 |
Effect of proton pump inhibitors on platelet inhibition activity of clopidogrel in Chinese patients with percutaneous coronary intervention.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Asian; Asian People; Blood Platelets; China; Clopidogrel; Drug Resistance; Esomeprazole; Female; Humans; Lansoprazole; Male; Middle Aged; New York City; Omeprazole; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors | 2011 |
Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting.
Topics: Aspirin; Cerebrovascular Circulation; Clopidogrel; Coronary Artery Bypass; Coronary Vessels; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Thrombosis; Ticlopidine | 2011 |
Ability of the INNOVANCE PFA P2Y system to detect clopidogrel-induced ADP receptor blockade in preangiocath individuals.
Topics: Adult; Angiography; Blood Coagulation; Blood Platelets; Clopidogrel; Coronary Artery Disease; Diagnostic Equipment; Drug Monitoring; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Ticlopidine; Young Adult | 2011 |
Usefulness of high clopidogrel maintenance dose according to CYP2C19 genotypes in clopidogrel low responders undergoing coronary stenting for non ST elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Alleles; Analysis of Variance; Aryl Hydrocarbon Hydroxylases; Chi-Square Distribution; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Endpoint Determination; Female; Flow Cytometry; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymerase Chain Reaction; Prospective Studies; Risk Assessment; Risk Factors; Statistics, Nonparametric; Stents; Ticlopidine; Treatment Outcome | 2011 |
Differential effect of clopidogrel and aspirin on the release of BDNF from platelets.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Brain-Derived Neurotrophic Factor; Clopidogrel; Gene Expression Regulation; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Transforming Growth Factor beta1 | 2011 |
The platelet hyporesponsiveness to clopidogrel in acute coronary syndrome patients treated with 75 mg/day clopidogrel may be overcome within 1 month of treatment.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Blood Platelets; Clopidogrel; Drug Administration Schedule; Female; Flow Cytometry; Humans; Leukocyte Count; Male; Middle Aged; Peptide Fragments; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Recent trends in Australian percutaneous coronary intervention practice: insights from the Melbourne Interventional Group registry.
Topics: Age Factors; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Australia; Clopidogrel; Comorbidity; Coronary Occlusion; Coronary Restenosis; Coronary Thrombosis; Diabetes Mellitus; Drug Utilization; Drug-Eluting Stents; Emergencies; Female; Hemorrhage; Hospital Mortality; Humans; Logistic Models; Male; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Renal Insufficiency; Shock, Cardiogenic; Ticlopidine | 2011 |
Malaysia-ACute CORonary syndromes Descriptive study (ACCORD): evaluation of compliance with existing guidelines in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Guideline Adherence; Humans; Malaysia; Male; Medication Adherence; Middle Aged; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Prospective Studies; Risk Factors; Ticlopidine | 2011 |
Clopidogrel effectively suppresses endothelial microparticle generation induced by indoxyl sulfate via inhibition of the p38 mitogen-activated protein kinase pathway.
Topics: Cell-Derived Microparticles; Cells, Cultured; Clopidogrel; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Indican; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Platelet Aggregation Inhibitors; Ticlopidine; Umbilical Veins | 2011 |
Sensitive troponin I assay in patients with suspected acute coronary syndrome.
Topics: Acute Coronary Syndrome; Clopidogrel; Creatinine; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Revascularization; Platelet Aggregation Inhibitors; Reproducibility of Results; Risk Factors; Ticlopidine; Troponin I | 2011 |
Poly-N-acetyl glucosamine fibers induce angiogenesis in ADP inhibitor-treated diabetic mice.
Topics: Acetylglucosamine; Animals; Clopidogrel; Diabetes Complications; Male; Mice; Mice, Inbred C57BL; Nanofibers; Neovascularization, Physiologic; Purinergic P2Y Receptor Antagonists; Ticlopidine; Wound Healing; Wounds and Injuries | 2011 |
Putting genomics into practice.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thromboembolism; Ticlopidine | 2011 |
Patent foramen ovale may be causal for the first stroke but unrelated to subsequent ischemic events.
Topics: Adult; Aged; Aspirin; Brain Ischemia; Clopidogrel; Female; Follow-Up Studies; Foramen Ovale, Patent; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Stroke; Ticlopidine; Treatment Outcome | 2011 |
Influence of platelet reactivity on outcome of patients with acute myocardial infarction undergoing primary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Relationship between paraoxonase Q192R gene polymorphism and on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryldialkylphosphatase; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2011 |
Clinical and prognostic implications of the initial response to aspirin in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Administration, Oral; Aspirin; Clopidogrel; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Antiplatelet therapy in percutaneous coronary intervention: is variability of response clinically relevant?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Thrombosis; Drug Therapy, Combination; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2011 |
Abrupt cessation of one-year clopidogrel treatment is not associated with thrombotic events.
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Substance Withdrawal Syndrome; Thrombosis; Ticlopidine | 2011 |
Direct vasoactive properties of thienopyridine-derived nitrosothiols.
Topics: Animals; Aorta, Thoracic; Clopidogrel; Glutathione; Guanylate Cyclase; Hydrogen-Ion Concentration; In Vitro Techniques; Luminescent Measurements; Male; Mass Spectrometry; Molecular Structure; Nitro Compounds; Oxadiazoles; Ozone; Piperazines; Prasugrel Hydrochloride; Quinoxalines; Rabbits; S-Nitrosothiols; Sodium Nitrite; Spectrophotometry, Ultraviolet; Thienopyridines; Thiophenes; Ticlopidine; Vasodilation; Vasodilator Agents | 2011 |
Relationship between cardiovascular outcomes and proton pump inhibitor use in patients receiving dual antiplatelet therapy after acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Databases, Factual; Drug Interactions; Esomeprazole; Female; Herb-Drug Interactions; Hospitalization; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Retrospective Studies; Ticlopidine; Treatment Outcome | 2011 |
Letter by Gasparovic et al regarding article, "Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the clopidogrel after surgery for coronary artery disease (CASCADE) trial".
Topics: Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Coronary Artery Disease; Drug Resistance; Follow-Up Studies; Graft Occlusion, Vascular; Hemorheology; Humans; Hyperplasia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Saphenous Vein; Ticlopidine; Tunica Intima | 2011 |
Letter by Bisdas et al regarding article, "Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the clopidogrel after surgery for coronary artery disease (CASCADE) trial".
Topics: Aspirin; Biotransformation; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Coronary Artery Disease; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Resistance; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Hyperplasia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Saphenous Vein; Ticlopidine; Tunica Intima | 2011 |
Emergency surgery following trancutaneous aortic valve insertion.
Topics: Aged, 80 and over; Aortic Valve; Aspirin; Blood Loss, Surgical; Clopidogrel; Emergency Medical Services; Femoral Neck Fractures; Heart Valve Prosthesis Implantation; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine | 2011 |
Study on bioavailability difference between clopidogrel bisulfate form I and form II using liquid chromatography/tandem mass spectrometry.
Topics: Animals; Area Under Curve; Atorvastatin; Biological Availability; Chromatography, High Pressure Liquid; Clopidogrel; Half-Life; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Ticlopidine | 2011 |
Dissecting the activation of thienopyridines by cytochromes P450 using a pharmacodynamic assay in vitro.
Topics: Aryl Hydrocarbon Hydroxylases; Baculoviridae; Biosensing Techniques; Biotransformation; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Assays; Humans; Microsomes; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Prasugrel Hydrochloride; Thienopyridines; Thiophenes; Ticlopidine | 2011 |
Acetylsalicylic acid, but not clopidogrel, inhibits therapeutically induced cerebral arteriogenesis in the hypoperfused rat brain.
Topics: Animals; Aspirin; Brain Ischemia; Cell Line; Cerebral Angiography; Cerebrovascular Circulation; Chemotaxis, Leukocyte; Clopidogrel; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Male; Monocytes; Neovascularization, Physiologic; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ticlopidine; Vasodilation | 2012 |
Use of clopidogrel and calcium channel blockers and risk of major adverse cardiovascular events.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amlodipine; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Cardiovascular Diseases; Child; Child, Preschool; Clopidogrel; Cohort Studies; Denmark; Drug Interactions; Felodipine; Female; Humans; Infant; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk; Stents; Ticlopidine; Verapamil; Young Adult | 2012 |
Anticoagulation and clinically significant postoperative vitreous hemorrhage in diabetic vitrectomy.
Topics: Anticoagulants; Aspirin; Clopidogrel; Diabetic Retinopathy; Female; Humans; Incidence; Intraoperative Complications; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome; Visual Acuity; Vitrectomy; Vitreous Hemorrhage; Warfarin | 2011 |
Effect of chronic kidney disease on platelet reactivity to dual-antiplatelet therapy in patients treated with drug-eluting stents.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Renal Insufficiency, Chronic; Retrospective Studies; Ticlopidine | 2012 |
Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates LPS-induced systemic inflammation in a rat model.
Topics: Animals; Clopidogrel; Humans; Inflammation; Interleukin-6; Lipopolysaccharides; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rats; Ticlopidine; Tumor Necrosis Factor-alpha | 2011 |
Atrial fibrillation treatment update.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Heart Rate; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Thromboembolism; Ticlopidine | 2011 |
Epistaxis as the reason for premature discontinuation of clopidogrel after percutaneous coronary angioplasty with stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Epistaxis; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Time Factors; Withholding Treatment | 2011 |
[Use of clopidogrel after PCI--why do patients quit?].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Epistaxis; Female; Humans; Male; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Withholding Treatment | 2011 |
Combined influence of proton-pump inhibitors, calcium-channel blockers and CYP2C19*2 on on-treatment platelet reactivity and on the occurrence of atherothrombotic events after percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Laser-Assisted; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Thrombosis; Ticlopidine | 2011 |
Stent-related cardiac events beyond three years after implantation of the sirolimus-eluting stent (from the EVASTENT Patients).
Topics: Clopidogrel; Cohort Studies; Coronary Artery Disease; Coronary Thrombosis; Diabetes Mellitus; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Matched-Pair Analysis; Middle Aged; Myocardial Revascularization; Platelet Aggregation Inhibitors; Registries; Sirolimus; Ticlopidine | 2011 |
Determination of cut-off levels for on-clopidogrel platelet aggregation based on functional CYP2C19 gene variants in patients undergoing elective percutaneous coronary intervention.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2011 |
Time dependence of clopidogrel loading effect: platelet activation versus platelet aggregation.
Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Annexin A5; Aspirin; Baltimore; Clopidogrel; Collagen; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme.
Topics: Aryl Hydrocarbon Hydroxylases; Base Sequence; Chromatography, High Pressure Liquid; Clopidogrel; Cysteine; Cytochrome P-450 CYP2B6; DNA Primers; Enzyme Inhibitors; Heme; Humans; Kinetics; Mutagenesis, Site-Directed; Oxidoreductases, N-Demethylating; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Ticlopidine | 2011 |
Clopidogrel: a drug with potential to prevent steroid-induced osteonecrosis?
Topics: Clopidogrel; Glucocorticoids; Humans; Methylprednisolone; Osteonecrosis; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
[Application of activated eptacog alfa in cardiac surgery].
Topics: Adult; Aged; Blood Loss, Surgical; Cardiac Surgical Procedures; Clopidogrel; Factor VIIa; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Premedication; Recombinant Proteins; Ticlopidine | 2011 |
Comparison of venous and arterial blood sampling for the assessment of platelet aggregation with whole blood impedance aggregometry.
Topics: Adenosine Diphosphate; Arachidonic Acid; Area Under Curve; Arteries; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Electric Impedance; Female; Humans; Male; Phlebotomy; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Research Design; Specimen Handling; Ticlopidine; Veins | 2011 |
Comparison of platelet reactivity and clopidogrel response in patients ≤ 75 Years Versus > 75 years undergoing percutaneous coronary intervention for non-ST-segment elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Age Factors; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Follow-Up Studies; Hemorrhage; Humans; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Stents; Ticlopidine | 2011 |
Safety of ultrasound-guided fine needle aspiration biopsy of neck lesions in patients taking antithrombotic/anticoagulant medications.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Biopsy, Fine-Needle; Chi-Square Distribution; Clopidogrel; Female; Head and Neck Neoplasms; Hematoma; Hemorrhage; Heparin; Humans; Male; Middle Aged; Retrospective Studies; Ticlopidine; Ultrasonography, Interventional; Warfarin | 2011 |
Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with death and myocardial infarction--a hospital registry-primary care linked cohort (MINAP-GPRD).
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Clopidogrel; Cohort Studies; Death, Sudden, Cardiac; Female; General Practice; Hospitalization; Humans; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Registries; Ticlopidine | 2011 |
[Platelet aggregation upon acetylsalicylic acid and clopidogrel treatment and glycoprotein IIb/IIIa content in patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Clopidogrel; Drug Administration Schedule; Drug Dosage Calculations; Electrocardiography; Female; Humans; Male; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Time Factors | 2011 |
[Comparison of efficacy and safety of treatment with drugs of clopidogrel in patients after coronary artery stenting].
Topics: Abdominal Pain; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Drug Substitution; Drugs, Generic; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stents; Therapeutic Equivalency; Ticlopidine; Treatment Outcome | 2011 |
Comparison of characteristics, management practices, and outcomes of patients between the global registry and the gulf registry of acute coronary events.
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Angiotensin Receptor Antagonists; Aspirin; Cardiac Catheterization; Clopidogrel; Diabetes Mellitus; Female; Fibrinolytic Agents; Heart Failure; Hemorrhage; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Mechanical Thrombolysis; Middle Aged; Middle East; Myocardial Revascularization; Platelet Aggregation Inhibitors; Registries; Sex Distribution; Shock, Cardiogenic; Smoking; Stroke; Ticlopidine | 2011 |
Impact of dyspnea on medical utilization and affiliated costs in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Costs and Cost Analysis; Diagnostic Techniques and Procedures; Drug Therapy, Combination; Dyspnea; Emergency Service, Hospital; Female; Humans; Insurance Claim Review; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2011 |
Three-year clinical outcome with the Endeavor™ zotarolimus-eluting stent in primary percutaneous coronary intervention for ST elevation myocardial infarction: the Endeavor™ primary PCI study (E-PPCI).
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Confidence Intervals; Drug-Eluting Stents; Female; Heparin; Humans; Immunosuppressive Agents; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome; United Kingdom | 2011 |
[Clinical importance of the clopidogrel - omeprazole interaction: a question to solve].
Topics: Clopidogrel; Controlled Clinical Trials as Topic; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2012 |
Optical coherence tomography findings during "evolving" stent thrombosis.
Topics: Abciximab; Antibodies, Monoclonal; Anticoagulants; Aspirin; Cardiopulmonary Resuscitation; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Coronary Vessels; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine; Tomography, Optical Coherence; Ultrasonography, Interventional | 2011 |
Desperate times, desperate measures: rotablating dissections in acute myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aortic Dissection; Aspirin; Atherectomy, Coronary; Clopidogrel; Female; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Normal chest radiograph and ground glass opacities on a thoracic computed tomographic scan in a patient with diffuse alveolar haemorrhage due to dual antiplatelet therapy prescribed after patent foramen ovale percutaneous device closure.
Topics: Adult; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Foramen Ovale, Patent; Hemoptysis; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Pulmonary Alveoli; Septal Occluder Device; Ticlopidine; Tomography, X-Ray Computed | 2011 |
Use of prasugrel in a patient with clopidogrel hypersensitivity.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug Hypersensitivity; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Ticagrelor (Brilinta)--better than clopidogrel (Plavix)?
Topics: Adenosine; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Approval; Drug Interactions; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Thiophenes; Ticagrelor; Ticlopidine; United States | 2011 |
Prolonged use of aspirin alters human and rat intestinal cells and thereby limits the absorption of clopidogrel.
Topics: Animals; Aspirin; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Survival; Clopidogrel; Drug Administration Schedule; Drug Interactions; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Ticlopidine | 2011 |
Antithrombotic therapy use at discharge and 1 year in patients with atrial fibrillation and acute stroke: results from the AVAIL Registry.
Topics: Aged; Aged, 80 and over; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Male; Middle Aged; Registries; Risk Factors; Stroke; Ticlopidine; Warfarin | 2011 |
Aspirin, clopidogrel, and warfarin use and outcomes in a cohort of 580 patients discharged after hospitalization for decompensated heart failure.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Chi-Square Distribution; Chronic Disease; Clopidogrel; Drug Interactions; Drug Utilization; Female; Health Care Surveys; Heart Failure; Humans; Male; Middle Aged; Patient Discharge; Patient Readmission; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proportional Hazards Models; Prospective Studies; Risk Factors; Stroke Volume; Ticlopidine; Time Factors; Turkey; Ventricular Function, Left; Warfarin | 2012 |
The use of ticagrelor in a patient at increased risk of stent thrombosis resistant to multiple thienopyridines.
Topics: Adenosine; Aged, 80 and over; Cardiac Catheterization; Clopidogrel; Drug-Eluting Stents; Humans; Male; Myocardial Infarction; Purinergic P2Y Receptor Antagonists; Thienopyridines; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2011 |
One-year outcomes with angiographic follow-up of paclitaxel-eluting balloon for the treatment of in-stent restenosis: insights from Spanish multicenter registry.
Topics: Angioplasty, Balloon; Anticoagulants; Antineoplastic Agents, Phytogenic; Aspirin; Clopidogrel; Confidence Intervals; Coronary Angiography; Coronary Restenosis; Drug-Eluting Stents; Female; Heparin; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Paclitaxel; Prospective Studies; Registries; Spain; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Evaluation of a microarray-based genotyping assay for the rapid detection of cytochrome P450 2C19 *2 and *3 polymorphisms from whole blood using nanoparticle probes.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Hematologic Tests; Humans; Nanospheres; Oligonucleotide Array Sequence Analysis; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine; Time Factors | 2011 |
Effect of paraoxonase-1 polymorphism on clinical outcomes in patients treated with clopidogrel after an acute myocardial infarction.
Topics: Aged; Aged, 80 and over; Aryldialkylphosphatase; Clopidogrel; Female; Follow-Up Studies; Genotype; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Polymorphism, Genetic; Prospective Studies; Registries; Ticlopidine; Treatment Outcome | 2011 |
Impact of gastric acid-suppressing therapies on platelet reactivity in patients with coronary artery disease treated with clopidogrel: results of a pharmacodynamic study.
Topics: Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2011 |
Clopidogrel pre-treatment is associated with reduced in-hospital mortality in primary percutaneous coronary intervention for acute ST-elevation myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Austria; Clopidogrel; Female; Hospital Mortality; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Patient Transfer; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Preoperative Care; Prospective Studies; Registries; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
[Antiplatelet agents increase hemorrhagic risk in patients undergoing a cardiac pacemaker or ICD implantation].
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Aspirin; Clopidogrel; Defibrillators, Implantable; Drug Therapy, Combination; France; Humans; Incidence; Length of Stay; Middle Aged; Multivariate Analysis; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Hemorrhage; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine | 2011 |
The effect of clopidogrel besylate and clopidogrel hydrogensulfate on platelet aggregation in patients with coronary artery disease: a retrospective study.
Topics: Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2012 |
Residual platelet reactivity after aspirin and clopidogrel treatment predicts 2-year major cardiovascular events in patients undergoing percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Preoperative Care; Prognosis; Retrospective Studies; Stroke; Survival Rate; Taiwan; Ticlopidine; Time Factors | 2011 |
Clopidogrel vs. aspirin treatment on admission improves 5-year survival after a first-ever acute ischemic stroke. data from the Athens Stroke Outcome Project.
Topics: Aged; Aspirin; Clopidogrel; Female; Greece; Humans; Male; Middle Aged; Multivariate Analysis; Patient Admission; Retrospective Studies; Ticlopidine | 2011 |
Imaging cardio-vascular anatomy and function in D-Transposition of the great arteries after mustard procedure.
Topics: Adult; Clopidogrel; Heart Arrest; Humans; Magnetic Resonance Angiography; Male; Platelet Aggregation Inhibitors; Radiography; Stroke; Ticlopidine; Transposition of Great Vessels; Ventricular Fibrillation | 2011 |
Intravascular ultrasound and angiographic demonstration of left main stem thrombus-high-risk presentation in a young adult with anabolic steroid abuse.
Topics: Abciximab; Anabolic Agents; Antibodies, Monoclonal; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Humans; Immunoglobulin Fab Fragments; Male; Platelet Aggregation Inhibitors; Substance-Related Disorders; Ticlopidine; Ultrasonography, Interventional; Young Adult | 2010 |
High residual platelet reactivity after clopidogrel loading and long-term cardiovascular events among patients with acute coronary syndromes undergoing PCI.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angioplasty; Aspirin; Clopidogrel; Death; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Risk; Stents; Stroke; Thrombosis; Ticlopidine | 2011 |
Applying platelet function testing in clinical practice: what are the unmet needs?
Topics: Acute Coronary Syndrome; Clopidogrel; Cohort Studies; Death; Humans; Myocardial Infarction; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Standard of Care; Stents; Thrombosis; Ticlopidine | 2011 |
Characterization of clopidogrel hypersensitivity reactions and management with oral steroids without clopidogrel discontinuation.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Disease Management; Drug Hypersensitivity; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prednisone; Skin Tests; Steroids; Ticlopidine | 2011 |
Cutaneous clopidogrel hypersensitivity: give steroids and do not stop the clopidogrel.
Topics: Clopidogrel; Drug Hypersensitivity; Female; Humans; Male; Prednisone; Ticlopidine | 2011 |
Clopidogrel and CYP2C19 testing: ready for clinical prime time?
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Genotype; Heterozygote; Humans; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2012 |
Drug name alert: potential for confusion between pradax and plavix.
Topics: Anticoagulants; Benzimidazoles; Clopidogrel; Dabigatran; Drug Therapy; Humans; Intracranial Aneurysm; Medication Errors; Medication Systems; Platelet Aggregation Inhibitors; Preoperative Care; Pyridines; Ticlopidine | 2011 |
Clopidogrel: is a surgical delay necessary in fractured neck of femur?
Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Clopidogrel; Dipyridamole; Female; Femoral Neck Fractures; Hemoglobins; Humans; Length of Stay; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Aborted myocardial infarction in a patient with rapid progression of Wellens syndrome.
Topics: Aspirin; Clopidogrel; Coronary Stenosis; Early Diagnosis; Electrocardiography; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2012 |
[Stent thrombosis and clopidogrel response variability: is the genetic test useful in clinical practice?].
Topics: Acute Coronary Syndrome; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Genetic Testing; Genotype; Humans; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Practice Patterns, Physicians'; Predictive Value of Tests; Risk Assessment; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Angioplasty; Anticoagulants; Antihypertensive Agents; Aspirin; Canada; Citalopram; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Fluoxetine; Fluvoxamine; Heart Failure; Hemorrhage; Humans; Hypoglycemic Agents; Male; Middle Aged; Myocardial Infarction; Neoplasms; Paroxetine; Peptic Ulcer; Platelet Aggregation Inhibitors; Renal Insufficiency; Retrospective Studies; Risk; Risk Factors; Secondary Prevention; Selective Serotonin Reuptake Inhibitors; Sertraline; Sex Factors; Ticlopidine | 2011 |
Perioperative management of clopidogrel therapy: the effects on in-hospital cardiac morbidity in older patients with hip fractures.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Blood Transfusion; Clopidogrel; Female; Hip Fractures; Humans; Male; Middle Aged; Morbidity; Perioperative Care; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors | 2011 |
The management of patients on oral anticoagulation undergoing coronary stent implantation: a survey among interventional cardiologists from eight European countries.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Europe; Health Care Surveys; Heparin, Low-Molecular-Weight; Humans; International Normalized Ratio; Practice Patterns, Physicians'; Preoperative Care; Stents; Ticlopidine | 2012 |
Effects of P2Y(1) receptor antagonism on the reactivity of platelets from patients with stable coronary artery disease using aspirin and clopidogrel.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Thrombin; Thrombosis; Ticlopidine | 2012 |
A case of acute stent thrombosis during treatment with the thrombopoietin receptor agonist peptide--romiplostim.
Topics: Acute Disease; Aspirin; Chest Pain; Clopidogrel; Eptifibatide; Female; Humans; Middle Aged; Peptides; Piperazines; Platelet Aggregation Inhibitors; Platelet Count; Prasugrel Hydrochloride; Purpura, Thrombocytopenic, Idiopathic; Receptors, Thrombopoietin; Risk Factors; Stents; Thiophenes; Thrombosis; Ticlopidine; Ultrasonography, Interventional | 2012 |
Determination of residual antiplatelet activity of clopidogrel before neuraxial injections.
Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Injections, Epidural; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors | 2011 |
Thrombus formation on a left atrial appendage closure device.
Topics: Aged; Anticoagulants; Aspirin; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Equipment Design; Heart Diseases; Heparin; Humans; Male; Postoperative Complications; Septal Occluder Device; Thrombophilia; Thrombosis; Ticlopidine; Ultrasonography | 2011 |
Risk factors for re-exploration due to bleeding after coronary artery bypass grafting.
Topics: Aged; Antifibrinolytic Agents; Aprotinin; Case-Control Studies; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Factors; Ticlopidine | 2012 |
Cilostazol to overcome high on-treatment platelet reactivity in korean patients treated with clopidogrel and calcium-channel blocker.
Topics: Calcium Channel Blockers; Cilostazol; Clopidogrel; Drug Antagonism; Female; Humans; Male; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine | 2011 |
Correlation between point-of-care platelet function testing and bleeding after coronary artery surgery.
Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Coronary Vessels; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Postoperative Care; Postoperative Hemorrhage; Ticlopidine | 2012 |
[Diagnostic laparoscopy under dual antiplatelet therapy with clopidogrel and aspirin].
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Diagnosis, Differential; Drug Substitution; Drug Therapy, Combination; Drug-Eluting Stents; Eptifibatide; Female; Humans; Laparoscopy; Multiple Myeloma; Peptides; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Factors; Thrombosis; Ticlopidine | 2011 |
Perioperative management of patients on clopidogrel (Plavix) undergoing major lung resection.
Topics: Aged; Clopidogrel; Eptifibatide; Humans; Middle Aged; Peptides; Perioperative Care; Platelet Aggregation Inhibitors; Pneumonectomy; Ticlopidine | 2011 |
Bivalirudin used as alternative anticoagulant in carotid artery stenting: a single center observational study.
Topics: Adult; Aged; Aged, 80 and over; Antithrombins; Carotid Stenosis; Clopidogrel; Female; Hirudins; Humans; Male; Middle Aged; Peptide Fragments; Platelet Aggregation Inhibitors; Recombinant Proteins; Ticlopidine | 2012 |
Use of early clopidogrel by reperfusion strategy among patients presenting with ST-segment elevation myocardial infarction.
Topics: Administration, Cutaneous; Aged; Angioplasty; Clopidogrel; Coronary Vessels; Electrocardiography; Female; Fibrinolysis; Humans; Male; Middle Aged; Myocardial Infarction; Practice Guidelines as Topic; Reperfusion; Survival Analysis; Ticlopidine | 2011 |
Treatment of a traumatic carotid-cavernous fistula by the sole use of a flow diverting stent.
Topics: Abducens Nerve Diseases; Accidents, Traffic; Angiography, Digital Subtraction; Aspirin; Brain Injuries; Carotid Artery, Internal; Carotid-Cavernous Sinus Fistula; Cerebral Angiography; Clopidogrel; Craniocerebral Trauma; Exophthalmos; Female; Humans; Ophthalmic Artery; Orbit; Paralysis; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Tomography, X-Ray Computed; Young Adult | 2012 |
Stent assisted coiling of the ruptured wide necked intracranial aneurysm.
Topics: Adult; Aneurysm, Ruptured; Aspirin; Clopidogrel; Cohort Studies; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Male; Middle Aged; Prospective Studies; Radiography; Retrospective Studies; Stents; Ticlopidine | 2012 |
Body weight: a risk factor for subtherapeutic antithrombotic therapy in neurovascular stenting.
Topics: Aspirin; Body Mass Index; Body Weight; Carotid Stenosis; Cerebrovascular Disorders; Clopidogrel; Female; Fibrinolytic Agents; Humans; Intracranial Aneurysm; Male; Middle Aged; Retrospective Studies; Risk Factors; Stents; Thrombolytic Therapy; Ticlopidine; Treatment Failure | 2011 |
Allergic reaction to prasugrel and cross-reactivity with clopidogrel.
Topics: Aged; Clopidogrel; Cross Reactions; Female; Humans; Hypersensitivity; Piperazines; Prasugrel Hydrochloride; Pruritus; Thiophenes; Ticlopidine | 2012 |
Impact of preinjury warfarin and antiplatelet agents on outcomes of trauma patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Child; Child, Preschool; Clopidogrel; Cohort Studies; Female; Humans; Infant; Intracranial Hemorrhages; Length of Stay; Male; Middle Aged; Multivariate Analysis; New York; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Risk Factors; Ticlopidine; Trauma Centers; Warfarin; Wounds and Injuries; Young Adult | 2011 |
Platelet response to standard aspirin and clopidogrel treatment correlates with long-term outcome in patients with acute ST-elevation myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Anti-inflammatory and anti-thrombotic intervention strategies using atorvastatin, clopidogrel and knock-down of CD40L do not modify radiation-induced atherosclerosis in ApoE null mice.
Topics: Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Atorvastatin; Carotid Arteries; CD40 Antigens; Clopidogrel; Disease Models, Animal; Heptanoic Acids; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Aggregation Inhibitors; Pyrroles; Radiation Dosage; Radiation Injuries, Experimental; Random Allocation; Reference Values; Statistics, Nonparametric; Ticlopidine | 2011 |
Interaction analysis between genetic polymorphisms and pharmacodynamic effect in patients treated with adjunctive cilostazol to dual antiplatelet therapy: results of the ACCEL-TRIPLE (Accelerated Platelet Inhibition by Triple Antiplatelet Therapy Accordin
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cilostazol; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Regression Analysis; Tetrazoles; Ticlopidine | 2012 |
Influence of high-density lipoprotein and paraoxonase-1 on platelet reactivity in patients with acute coronary syndromes receiving clopidogrel therapy.
Topics: Acute Coronary Syndrome; Aged; Aryldialkylphosphatase; Base Sequence; Cell Adhesion Molecules; Clopidogrel; DNA Primers; Female; Flow Cytometry; Genotype; Humans; Lipoproteins, HDL; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Carbon monoxide-releasing molecule-2 enhances coagulation in rabbit plasma and decreases bleeding time in clopidogrel/aspirin-treated rabbits.
Topics: Administration, Oral; Animals; Aspirin; Bleeding Time; Blood Coagulation; Carbon Monoxide; Clopidogrel; Fibrinolytic Agents; Hemorrhage; Injections, Intravenous; Male; Organometallic Compounds; Plasma; Platelet Aggregation Inhibitors; Rabbits; Thrombelastography; Ticlopidine | 2011 |
Unraveling the pharmacogenetics of clopidogrel: the paraoxonase-1 controversy.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Testing should not be done in all patients treated with clopidogrel who are undergoing percutaneous coronary intervention.
Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers, Pharmacological; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Platelet function profiles in the elderly: results of a pharmacodynamic study in patients on clopidogrel therapy and effects of switching to prasugrel 5 mg in patients with high platelet reactivity.
Topics: Aged; Aged, 80 and over; Blood Platelets; Clinical Protocols; Clopidogrel; Drug Substitution; Female; Humans; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2011 |
[Efficacy and tolerability of a clopidogrel desensitization protocol].
Topics: Aged; Aged, 80 and over; Clopidogrel; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Clinical update on nursing home medicine: 2011.
Topics: Anti-Ulcer Agents; Anticoagulants; Atrial Fibrillation; Clopidogrel; Clostridioides difficile; Delirium; Diabetes Complications; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; Fractures, Bone; Geriatric Nursing; Humans; Male; Nursing Homes; Omeprazole; Osteoporosis; Peptic Ulcer; Platelet Aggregation Inhibitors; Pneumonia, Bacterial; Polypharmacy; Proton Pump Inhibitors; Risk Factors; Ticlopidine; Warfarin; Weight Loss | 2011 |
Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cytochrome P-450 CYP2C19; DNA; Female; France; Genetic Predisposition to Disease; Genotype; Humans; Integrin beta3; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prognosis; Proton Pump Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2011 |
Clopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis.
Topics: Animals; Arthritis, Experimental; Clopidogrel; Cytokines; Disease Models, Animal; Drug Synergism; Female; Inflammation; Leukocytosis; Neutrophils; Peptidoglycan; Platelet Aggregation; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y12; Thrombocytosis; Ticlopidine | 2011 |
Illustration of the impact of antiplatelet drugs on the genesis and management of chronic subdural hematoma.
Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Hematoma, Subdural, Acute; Hematoma, Subdural, Chronic; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Remission Induction; Risk Factors; Ticlopidine; Withholding Treatment | 2012 |
CYP2C19 gene variants cut-off levels for on-clopidogrel platelet aggregation.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Genetic Variation; Humans; Japan; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prevalence; Thrombosis; Ticlopidine | 2012 |
On-clopidogrel platelet reactivity: a target in sight?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine | 2011 |
Leucocytoclastic vasculitis associated with clopidogrel.
Topics: Clopidogrel; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Vasculitis, Leukocytoclastic, Cutaneous | 2012 |
Increased clopidogrel response is associated with ABCC3 expression: a pilot study.
Topics: Aged; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Coronary Artery Disease; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Pilot Projects; RNA, Messenger; Ticlopidine; Treatment Outcome | 2012 |
Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to long-distance transfers.
Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Emergency Treatment; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Patient Transfer; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Rural Health; Tenecteplase; Ticlopidine; Tissue Plasminogen Activator; Treatment Outcome | 2012 |
Femoral neck fractures in patients on Clopidogrel. The effect of delaying surgery and the introduction of the new SIGN guidelines.
Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Clopidogrel; Female; Femoral Neck Fractures; Humans; Male; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine; Time Factors | 2011 |
Selecting the optimal stroke prevention therapy in atrial fibrillation.
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2011 |
Antiplatelet and anticoagulant therapy in patients with gastrointestinal bleeding: an 86-year-old woman with peptic ulcer disease.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Peptic Ulcer; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine; Warfarin | 2011 |
Effect of CYP2C19*2 and *3 loss-of-function alleles on platelet reactivity and adverse clinical events in East Asian acute myocardial infarction survivors treated with clopidogrel and aspirin.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Asia, Eastern; Asian People; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Myocardial Infarction; Pharmacogenetics; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine; Treatment Outcome | 2011 |
The HEART study: a real-world experience using the CID Chrono Carbostent in primary and rescue PCI.
Topics: Aged; Aspirin; Chi-Square Distribution; Chromium Alloys; Clopidogrel; Coated Materials, Biocompatible; Disease-Free Survival; Drug Therapy, Combination; Female; Hospital Mortality; Hospitals, High-Volume; Humans; Italy; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prosthesis Design; Recurrence; Registries; Risk Factors; Severity of Illness Index; Shock, Cardiogenic; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Concomitant use of clopidogrel and proton pump inhibitors is not associated with major adverse cardiovascular events following coronary stent implantation.
Topics: Adult; Aged; Aged, 80 and over; Catheter Ablation; Clopidogrel; Cohort Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Female; Gastroesophageal Reflux; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Stents; Ticlopidine | 2012 |
Perioperative management of patients receiving anticoagulant or antiplatelet therapy: a clinician-oriented and practical approach.
Topics: Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Evidence-Based Medicine; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Risk Assessment; Surgical Procedures, Operative; Thromboembolism; Thrombolytic Therapy; Ticlopidine; Warfarin | 2011 |
Preemptive genotyping trialed to prevent adverse drug reactions.
Topics: Clinical Trials as Topic; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Genetic Testing; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Cost-effectiveness of prasugrel in a US managed care population.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Cost Control; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Humans; Interviews as Topic; Male; Managed Care Programs; Middle Aged; Models, Economic; Outcome Assessment, Health Care; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; United States | 2012 |
High on-thienopyridine platelet reactivity in elderly coronary patients: the SENIOR-PLATELET study.
Topics: Acute Coronary Syndrome; Adult; Age Factors; Aged; Aged, 80 and over; Clopidogrel; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Thiophenes; Ticlopidine | 2012 |
SAMMPRIS: end of intracranial stenting for atherosclerosis or back to the drawing board?
Topics: Cerebral Angiography; Clopidogrel; Female; Humans; Intracranial Arteriosclerosis; Male; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Stroke; Ticlopidine | 2011 |
Role of newly formed platelets in thrombus formation in rat after clopidogrel treatment: comparison to the reversible binding P2Y₁₂ antagonist ticagrelor.
Topics: Adenosine; Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Cytoprotection; Platelet Activation; Protein Binding; Purinergic P2Y Receptor Antagonists; Rats; Rats, Inbred WKY; Thrombosis; Ticagrelor; Ticlopidine | 2011 |
Differential impact of cytochrome 2C9 allelic variants on clopidogrel-mediated platelet inhibition determined by five different platelet function tests.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C9; Female; Genetic Variation; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Ticlopidine | 2013 |
Variability and treatment of high on-prasugrel platelet reactivity in patients with initial high on-clopidogrel platelet reactivity.
Topics: Blood Platelet Disorders; Clopidogrel; Female; Humans; Male; Middle Aged; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2012 |
Platelet inhibition and surgical bleeding. A plea for more science and evidence-based guidelines.
Topics: Blood Transfusion; Cardiac Surgical Procedures; Clopidogrel; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Preoperative Care; Ticlopidine | 2011 |
[Impact of cytochrome P450 2C19 polymorphisms on outcome of cardiovascular events in clopidogrel-treated Chinese patients after percutaneous coronary intervention].
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prognosis; Ticlopidine | 2011 |
Is it time to implement preoperative platelet function testing before invasive procedures?
Topics: Adrenal Cortex Hormones; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Level of systolic blood pressure within the normal range and risk of recurrent stroke.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Benzimidazoles; Benzoates; Blood Pressure; Brain Ischemia; Clopidogrel; Diastole; Dipyridamole; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Reference Values; Risk; Stroke; Systole; Telmisartan; Ticlopidine; Vascular Diseases | 2011 |
[Clopidogrel induced thrombotic thrombocytopenic purpura].
Topics: Clopidogrel; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2011 |
No free lunches: balancing bleeding and efficacy with ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Ticagrelor; Ticlopidine | 2011 |
Effect of clopidogrel on circulating biomarkers of angiogenesis and endothelial activation.
Topics: Adolescent; Adult; Angiogenesis Inducing Agents; Biomarkers; Chemokine CXCL12; Clopidogrel; E-Selectin; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Humans; Male; Placenta Growth Factor; Platelet Aggregation Inhibitors; Pregnancy Proteins; Ticlopidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; von Willebrand Factor | 2012 |
Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.
Topics: Aryldialkylphosphatase; Biotransformation; Catalysis; Clopidogrel; Cytochrome P-450 Enzyme System; Humans; Isomerism; Microsomes, Liver; Platelet Aggregation Inhibitors; Serum; Sulfhydryl Compounds; Ticlopidine | 2012 |
Coronary artery stents and antiplatelet therapy in patients with cirrhosis.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Fatty Liver; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stents; Ticlopidine | 2012 |
Prognostic implications of early and long-term bleeding events in patients on one-year dual antiplatelet therapy following drug-eluting stent implantation.
Topics: Aged; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Incidence; Italy; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prevalence; Prosthesis Design; Registries; Risk Assessment; Risk Factors; Severity of Illness Index; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Medical management trumps stenting for intracranial arterial stenosis.
Topics: Angioplasty; Aspirin; Cerebral Arteries; Clopidogrel; Combined Modality Therapy; Constriction, Pathologic; Early Termination of Clinical Trials; Humans; Intracranial Arteriosclerosis; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stents; Stroke; Ticlopidine | 2011 |
Post percutaneous coronary intervention antiplatelet therapy: current perceptions, prospects and perplexity.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Cilostazol; Clopidogrel; Coronary Restenosis; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Metals; Patient Selection; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prosthesis Design; Risk Assessment; Risk Factors; Stents; Tetrazoles; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2011 |
Invited commentary.
Topics: Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Pneumonectomy; Ticlopidine | 2011 |
Influence of CYP2C19 polymorphisms in platelet reactivity and prognosis in an unselected population of non ST elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Genotype; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Phenotype; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Prognosis; Regression Analysis; Ticlopidine | 2012 |
[Acute coronary syndromes in hospitalized patients with diabetes. Data from the RECORD registry].
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clinical Protocols; Clopidogrel; Coronary Angiography; Diabetes Mellitus, Type 2; Electrocardiography; Female; Hospital Mortality; Humans; Male; Outcome and Process Assessment, Health Care; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk Factors; Ticlopidine | 2011 |
Relationship between cytochrome P450 2C19*2 polymorphism and stent thrombosis following percutaneous coronary intervention in Chinese patients receiving clopidogrel.
Topics: Aged; Aged, 80 and over; Amplified Fragment Length Polymorphism Analysis; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; China; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Proportional Hazards Models; Ticlopidine | 2011 |
Successful use of prasugrel, an alternative antiplatelet agent, in a patient with clopidogrel allergy.
Topics: Clopidogrel; Drug Hypersensitivity; Humans; Hypersensitivity, Immediate; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2011 |
Clinical outcomes following coronary stenting in Japanese patients treated with and without proton pump inhibitor.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Asian People; Aspirin; Clopidogrel; Coronary Disease; Female; Follow-Up Studies; Heartburn; Hematemesis; Humans; Incidence; Japan; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Registries; Retrospective Studies; Stents; Stroke; Ticlopidine; Treatment Outcome | 2012 |
Clopidogrel (plavix).
Topics: Clopidogrel; Dose-Response Relationship, Drug; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2011 |
Risk of bleeding after percutaneous endoscopic gastrostomy (PEG).
Topics: Aged; Anticoagulants; Clopidogrel; Female; Gastrointestinal Hemorrhage; Gastroscopy; Gastrostomy; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Factors; Ticlopidine | 2012 |
Anti-platelet therapy and managing ulcer risk.
Topics: Animals; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Combined Modality Therapy; Cytochrome P-450 CYP2C19; Drug Interactions; Enzyme Inhibitors; Helicobacter Infections; Helicobacter pylori; Humans; Patient Selection; Peptic Ulcer; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine | 2012 |
Platelet function profile post-clopidogrel therapy in patients with type 2 diabetes undergoing coronary stent implantation.
Topics: Aged; Clopidogrel; Coronary Vessels; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine | 2012 |
Clopidogrel use and early outcomes among older patients receiving a drug-eluting coronary artery stent.
Topics: Age Factors; Aged; Aged, 80 and over; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Dementia; Drug-Eluting Stents; Female; Humans; Male; Medicare Part D; Medication Adherence; Platelet Aggregation Inhibitors; Retrospective Studies; Survival Analysis; Thrombosis; Ticlopidine; United States | 2012 |
Modified clopidogrel loading dose according to platelet reactivity monitoring in patients carrying ABCB1 variant alleles in patients with clopidogrel resistance.
Topics: Aged; Alleles; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Drug Monitoring; Drug Resistance; Female; Humans; Male; Mutation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2012 |
Managing antiplatelet therapy during ophthalmic procedures: communication is the key.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Cardiology; Clopidogrel; Humans; Interdisciplinary Communication; Ophthalmologic Surgical Procedures; Ophthalmology; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2011 |
Clopidogrel therapy in ophthalmic procedures: a survey of subspecialty ophthalmologists and review of current guidelines.
Topics: Clopidogrel; Guideline Adherence; Health Knowledge, Attitudes, Practice; Health Surveys; Humans; Medicine; Ophthalmologic Surgical Procedures; Ophthalmology; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Thrombosis; Ticlopidine | 2011 |
Influence of cytochrome 2C19 allelic variants on on-treatment platelet reactivity evaluated by five different platelet function tests.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2012 |
Renal function assessed using cystatin C and antiplatelet efficacy of clopidogrel assessed using the vasodilator-stimulated phosphoprotein index in patients having percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Proteins; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Cystatin C; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Immunoassay; Kidney Function Tests; Male; Microfilament Proteins; Phosphoproteins; Platelet Aggregation Inhibitors; Prognosis; Stents; Ticlopidine | 2012 |
Prevalence of inadequate platelet inhibition by clopidogrel in patients receiving hemodialysis.
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prevalence; Prospective Studies; Renal Dialysis; Ticlopidine; Treatment Failure | 2012 |
The relevance of P2Y(12)-receptor gene variation for the outcome of clopidogrel-treated patients undergoing elective coronary stent implantation: a clinical follow-up.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Female; Follow-Up Studies; Genetic Variation; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Polymorphism, Single Nucleotide; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Software; Stents; Ticlopidine | 2012 |
Dose-dependent effect of early antiplatelet therapy in acute ischaemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Body Mass Index; Brain Ischemia; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Ischemia; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Ticlopidine | 2012 |
Bleeding complications in primary percutaneous coronary intervention of ST-elevation myocardial infarction in a radial center.
Topics: Abciximab; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Clopidogrel; Female; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Hemorrhage; Hospital Mortality; Humans; Immunoglobulin Fab Fragments; Incidence; Internet; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Paris; Platelet Aggregation Inhibitors; Proportional Hazards Models; Radial Artery; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
[Perioperative anti-platelet therapy management--protocol suggestion].
Topics: Aspirin; Blood Loss, Surgical; Clinical Protocols; Clopidogrel; Drug Therapy, Combination; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Risk Factors; Thromboembolism; Ticlopidine | 2011 |
An unexpected evolution of symptomatic mild middle cerebral artery (MCA) stenosis: asymptomatic occlusion.
Topics: Adult; Aphasia; Aspirin; Clopidogrel; Female; Humans; Infarction, Middle Cerebral Artery; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2011 |
Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress.
Topics: Animals; Aorta; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Clopidogrel; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Glutathione Transferase; Humans; In Vitro Techniques; Mice; Mice, Knockout; Models, Animal; Muscle, Smooth, Vascular; Oxidative Stress; Pregnane X Receptor; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Steroid; Ticlopidine; Xenobiotics | 2012 |
Prediction of clopidogrel low responders by a rapid CYP2C19 activity test.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aryl Hydrocarbon Hydroxylases; Breath Tests; Carbon Radioisotopes; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Male; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prognosis; Proton Pump Inhibitors; Ticlopidine; Tissue Distribution | 2012 |
A sensitive and rapid ultra HPLC-MS/MS method for the simultaneous detection of clopidogrel and its derivatized active thiol metabolite in human plasma.
Topics: Chromatography, High Pressure Liquid; Clopidogrel; Drug Stability; Humans; Reproducibility of Results; Sensitivity and Specificity; Sulfhydryl Compounds; Tandem Mass Spectrometry; Ticlopidine | 2012 |
[A case of clopidogrel-induced eosinophilic pneumonia].
Topics: Aged, 80 and over; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Pulmonary Eosinophilia; Ticlopidine | 2011 |
Conflicting meta-analytic results: potential for confusion if left unexplained.
Topics: Clopidogrel; Coronary Artery Bypass; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
No one-size-fits-all: A tailored approach to antithrombotic therapy after stent implantation.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Coronary Disease; Coronary Restenosis; Drug-Eluting Stents; Electrocardiography; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2012 |
Factors influencing mortality in patients on antiplatelet agents presenting with proximal femoral fractures.
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Cerebrovascular Disorders; Clopidogrel; Comorbidity; Femoral Neck Fractures; Fracture Fixation, Internal; Hip Fractures; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
Unilateral femoral arterial thrombosis in a dog with malignant mammary gland tumor: clinical and thermographic findings, and successful treatment with local intra-arterial administration of streptokinase.
Topics: Animals; Anticoagulants; Clopidogrel; Dog Diseases; Dogs; Female; Femoral Artery; Fibrinolytic Agents; Mammary Neoplasms, Animal; Streptokinase; Thrombosis; Ticlopidine | 2012 |
Low mean corpuscular hemoglobin level is a predictor of discontinuation of antiplatelet therapy in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Erythrocyte Indices; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Patient Compliance; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine | 2011 |
Stent-assisted coiling of wide-necked aneurysms in the setting of acute subarachnoid hemorrhage: experience in 65 patients.
Topics: Adult; Aged; Aged, 80 and over; Blood Vessel Prosthesis; Clopidogrel; Embolization, Therapeutic; Endovascular Procedures; Female; Glasgow Outcome Scale; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Subarachnoid Hemorrhage; Ticlopidine; Treatment Outcome | 2012 |
Predicting clopidogrel response using DNA samples linked to an electronic health record.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clopidogrel; Cytochrome P-450 CYP2C19; Databases, Nucleic Acid; Electronic Health Records; Female; Genotype; Humans; Male; Myocardial Infarction; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Hematoma risk after needle electromyography.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Case-Control Studies; Clopidogrel; Electromyography; Female; Hematoma; Humans; Male; Middle Aged; Muscular Diseases; Needles; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Ultrasonography, Doppler; Warfarin; Young Adult | 2012 |
[Effects of proton pump inhibitors on in-stent restenosis in patients receiving clopidogrel: a retrospective analysis].
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Restenosis; Drug Antagonism; Drug Therapy, Combination; Follow-Up Studies; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk; Stents; Ticlopidine | 2011 |
In support of early surgery for hip fractures sustained by elderly patients taking clopidogrel: a retrospective study.
Topics: Aged, 80 and over; Clopidogrel; Female; Hip Fractures; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Editorial - do not throw the baby out with the bathwater….
Topics: Angioplasty; Aspirin; Carotid Stenosis; Clopidogrel; Humans; Multicenter Studies as Topic; National Institute of Neurological Disorders and Stroke (U.S.); Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Stroke; Ticlopidine; United States | 2011 |
Myelodysplastic syndrome associated with clopidogrel: a case report.
Topics: Aged; Clopidogrel; Female; Humans; Myelodysplastic Syndromes; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Impact of clopidogrel on bleeding complications and survival in off-pump coronary artery bypass grafting.
Topics: Aged; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Restenosis; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Germany; Hospital Mortality; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Retrospective Studies; Risk Factors; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
A surveillance tool to support quality assurance and research in personalized medicine.
Topics: Aryl Hydrocarbon Hydroxylases; Biomedical Research; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Computer-Assisted; Drug-Eluting Stents; Genotype; Humans; Pharmacogenetics; Pilot Projects; Platelet Aggregation Inhibitors; Precision Medicine; Quality Assurance, Health Care; Ticlopidine; User-Computer Interface | 2011 |
Immature platelet fraction (IPF) determined with an automated method predicts clopidogrel hyporesponsiveness.
Topics: Adult; Automation, Laboratory; Blood Platelets; Clopidogrel; Female; Forecasting; Humans; Male; Platelet Aggregation; Platelet Function Tests; Ticlopidine | 2012 |
Pharmacogenomics and clopidogrel: irrational exuberance?
Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2011 |
My patient just had a transient ischaemic attack. Can I predict his risk for stroke? Is stroke inevitable or preventable?
Topics: Aspirin; Clopidogrel; Evidence-Based Medicine; Humans; Ischemic Attack, Transient; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2011 |
Insufficient platelet inhibition is related to silent embolic cerebral infarctions after coronary angiography.
Topics: Aged; Aspirin; Atherosclerosis; Basilar Artery; Carotid Arteries; Cerebral Infarction; Clopidogrel; Coronary Angiography; Data Interpretation, Statistical; Diffusion Magnetic Resonance Imaging; Drug Resistance; Female; Hemoglobins; Humans; Intracranial Embolism; Leukocyte Count; Logistic Models; Magnetic Resonance Angiography; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Vertebral Artery | 2012 |
Clopidogrel responsiveness in stroke patients on a chronic aspirin regimen.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Equipment Design; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Predictive Value of Tests; Reproducibility of Results; Stroke; Thrombelastography; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Gene therapy with iNOS enhances regional contractility and reduces delayed contrast enhancement in a model of postischemic congestive heart failure.
Topics: Animals; Anticoagulants; Aspirin; Clopidogrel; Contrast Media; Coronary Angiography; Coronary Stenosis; Disease Models, Animal; Drug Carriers; Female; Fibrosis; Gadolinium; Genes, Reporter; Genes, Synthetic; Genetic Therapy; Heart Failure; Liposomes; Magnetic Resonance Imaging; Male; Myocardial Contraction; Myocardial Ischemia; Nitric Oxide Synthase Type II; Random Allocation; Stents; Sus scrofa; Swine; Ticlopidine; Ventricular Dysfunction, Left | 2011 |
Cost-effectiveness of clopidogrel plus aspirin for stroke prevention in patients with atrial fibrillation in whom warfarin is unsuitable.
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clinical Trials as Topic; Clopidogrel; Cohort Studies; Computer Simulation; Cost-Benefit Analysis; Drug Therapy, Combination; Follow-Up Studies; Humans; Markov Chains; Medicare; Monte Carlo Method; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Research Design; Risk Factors; Stroke; Survival Rate; Ticlopidine; Treatment Outcome; United States; Warfarin | 2012 |
Myocardial infarction in an young patient associated with oral contraceptive, smoking and elevated cholesterol level.
Topics: Abortion, Induced; Adult; Anticholesteremic Agents; Anticoagulants; Atorvastatin; Clopidogrel; Contraceptives, Oral; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Myocardial Infarction; Pregnancy; Pyrroles; Smoking; Ticlopidine | 2012 |
Development and validation of a liquid chromatographic method for purity control of clopidogrel-acetylsalicylic acid in combined oral dosage forms.
Topics: Administration, Oral; Aspirin; Chromatography, Liquid; Chromatography, Reverse-Phase; Clopidogrel; Dosage Forms; Drug Combinations; Drug Contamination; Ticlopidine | 2012 |
Warfarin use in nursing home residents: results from the 2004 national nursing home survey.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Cross-Sectional Studies; Health Care Surveys; Humans; Middle Aged; Nursing Homes; Platelet Aggregation Inhibitors; Ticlopidine; United States; Warfarin | 2012 |
Effects of the CYP2B6*6 allele on catalytic properties and inhibition of CYP2B6 in vitro: implication for the mechanism of reduced efavirenz metabolism and other CYP2B6 substrates in vivo.
Topics: Alkynes; Alleles; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Biotransformation; Bupropion; Catalysis; Clopidogrel; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochromes b5; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Pyrimidines; Substrate Specificity; Ticlopidine; Triazoles; Voriconazole | 2012 |
Frequency of heparin/platelet factor 4-dependent platelet antibodies in patients undergoing angioplasty and stenting for cardiovascular disease and their role for on-clopidogrel platelet reactivity.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Antibodies; Anticoagulants; Cardiovascular Diseases; Clopidogrel; Enzyme-Linked Immunosorbent Assay; Heparin; Humans; Immunoassay; Immunoglobulin G; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Factor 4; Stents; Ticlopidine | 2012 |
Effect of individual proton pump inhibitors on cardiovascular events in patients treated with clopidogrel following coronary stenting: results from the Ibaraki Cardiac Assessment Study Registry.
Topics: Aged; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Incidence; Japan; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Proton Pump Inhibitors; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Effect size of ticagrelor over clopidogrel in the Platelet Inhibition and Patient Outcomes (PLATO) trial: from statistics to clinical judgment.
Topics: Acute Coronary Syndrome; Adenosine; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Data Interpretation, Statistical; Humans; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Pharmacogenetics of clopidogrel: comparison between a standard and a rapid genetic testing.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Ticlopidine; Time Factors | 2012 |
[Absorption dynamic characteristics of clopidogrel bisulfate polymorphs in rat].
Topics: Absorption; Administration, Oral; Animals; Area Under Curve; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Clopidogrel; Crystallization; Male; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Wistar; Spectrophotometry, Infrared; Ticlopidine; X-Ray Diffraction | 2011 |
Concomitant use of clopidogrel and statins and risk of major adverse cardiovascular events following coronary stent implantation.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Denmark; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Regression Analysis; Risk Factors; Stents; Ticlopidine; Time Factors | 2012 |
Beneficial impact of prolonged dual antiplatelet therapy after drug-eluting stent implantation.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Myocardial Revascularization; Off-Label Use; Platelet Aggregation Inhibitors; Registries; Retreatment; Retrospective Studies; Ticlopidine | 2012 |
Prior antiplatelet use and cardiovascular outcomes in patients presenting with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Hospital Mortality; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Ventricular Dysfunction, Left | 2012 |
Phenotyping vs. genotyping for prediction of clopidogrel efficacy and safety: the PEGASUS-PCI study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Austria; Blood Platelets; Cardiovascular Diseases; Cell Adhesion Molecules; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Hemorrhage; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Microfilament Proteins; Middle Aged; Multivariate Analysis; Pharmacogenetics; Phenotype; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Sensitivity and Specificity; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Persistence, adherence and outcomes with antiplatelet regimens following cerebral infarction in the Tayside Stroke Cohort.
Topics: Aged; Aspirin; Cerebral Infarction; Clopidogrel; Cohort Studies; Dipyridamole; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization; Female; Humans; Male; Medical Record Linkage; Medical Records Systems, Computerized; Medication Adherence; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proportional Hazards Models; Radiography; Risk Assessment; Risk Factors; Scotland; Survival Analysis; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
CYP2C19 and clopidogrel response: more than validation in the real world.
Topics: Clopidogrel; Databases, Nucleic Acid; Electronic Health Records; Female; Humans; Male; Myocardial Infarction; Pharmacogenetics; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2012 |
Extension of Kaplan-Meier methods in observational studies with time-varying treatment.
Topics: Age Factors; Aged; Clopidogrel; Comorbidity; Confounding Factors, Epidemiologic; Coronary Artery Disease; Drug-Eluting Stents; Female; Health Behavior; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Sex Factors; Ticlopidine; Time Factors | 2012 |
Ticagrelor, but not clopidogrel and prasugrel, prevents ADP-induced vascular smooth muscle cell contraction: a placebo-controlled study in rats.
Topics: Adenosine; Adenosine Diphosphate; Animals; Arteries; Clopidogrel; Muscle Contraction; Myocytes, Smooth Muscle; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Rats; Rats, Wistar; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Occlusion of modified Blalock-Taussig shunt after clopidogrel cessation.
Topics: Anticoagulants; Aspirin; Blalock-Taussig Procedure; Clopidogrel; Fatal Outcome; Graft Occlusion, Vascular; Heart Arrest; Heart Septal Defects, Ventricular; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Pulmonary Atresia; Reoperation; Status Epilepticus; Substance Withdrawal Syndrome; Ticlopidine; Tricuspid Atresia | 2012 |
Toward a therapeutic window for antiplatelet therapy in the elderly.
Topics: Acute Coronary Syndrome; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2012 |
"Conversations in cardiology": How do you pick the best antiplatelet drug--clopidogrel, prasugrel, ticagrelor for your PCI patient?
Topics: Adenosine; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Thrombosis; Decision Making; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2012 |
Platelet function after cessation of chronic clopidogrel therapy.
Topics: Aged; Blood Platelets; Clopidogrel; Drug Monitoring; Female; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2012 |
Vasodilator-stimulated phosphoprotein-phosphorylation assay in patients on clopidogrel: does standardisation matter?
Topics: Blood Specimen Collection; Cell Adhesion Molecules; Cell Separation; Clopidogrel; Coronary Artery Disease; Flow Cytometry; Humans; Microfilament Proteins; Observer Variation; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Function Tests; Prospective Studies; Reference Standards; Ticlopidine; Vasodilator Agents | 2012 |
Antiplatelet therapy for transient ischemic attack.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Ischemia; Clopidogrel; Cognition Disorders; Diffusion Magnetic Resonance Imaging; Dipyridamole; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Primary Prevention; Prognosis; Secondary Prevention; Stroke; Ticlopidine | 2012 |
Bare metal stent thrombosis in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Clopidogrel; Female; Humans; Incidence; Male; Middle Aged; Risk Factors; Smoking; Stents; Thrombosis; Ticlopidine | 2012 |
Impact of anemia on platelet response to clopidogrel in patients undergoing percutaneous coronary stenting.
Topics: Adenosine Diphosphate; Aged; Anemia; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Hemoglobins; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Registries; Stents; Ticlopidine | 2012 |
New look at antiplatelet agent-related peptic ulcer: an update of prevention and treatment.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Thiophenes; Ticlopidine | 2012 |
Value of CYP2C19 *2 and *17 genotyping in clinical practice. Promising but not ready yet.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Safety of endobronchial ultrasound-guided transbronchial needle aspiration for patients taking clopidogrel: a report of 12 consecutive cases.
Topics: Aged; Aged, 80 and over; Biopsy, Fine-Needle; Bronchoscopy; Clopidogrel; Endosonography; Female; Follow-Up Studies; Hemorrhage; Humans; Lung Neoplasms; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Safety Management; Sampling Studies; Ticlopidine | 2012 |
The safety of major head and neck surgery in patients taking clopidogrel (Plavix).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Thrombosis; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Ticlopidine; Young Adult | 2012 |
Proton pump inhibitor and clopidogrel interaction: is it clinically significant?
Topics: Binding, Competitive; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2011 |
Desensitization to prasugrel: cardiology's increased need for allergy consultation.
Topics: Atherectomy, Coronary; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Artery Disease; Desensitization, Immunologic; Drug Dosage Calculations; Drug Hypersensitivity; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Referral and Consultation; Stents; Thiophenes; Ticlopidine | 2012 |
Use of an objective tool to assess platelet inhibition prior to off-pump coronary surgery to reduce blood usage.
Topics: Adenosine Diphosphate; Aged; Blood Coagulation Tests; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Reoperation; Ticlopidine | 2012 |
Coronary artery bypass graft surgery in patients receiving antiplatelet therapy: can we "fine-tune" the balance of safety and efficacy?
Topics: Blood Coagulation Tests; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Successful use of glycoprotein IIb/IIIa inhibitor, heparin, and IABP during PCI in a post-neurosurgical patient with STEMI and cardiogenic shock due to very late bare-metal stent thrombosis.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Heparin; Humans; Intra-Aortic Balloon Pumping; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Complications; Shock, Cardiogenic; Spinal Fusion; Stents; Thrombosis; Ticlopidine | 2012 |
Anatomical and visual results of transconjunctival sutureless vitrectomy using subconjunctival anesthesia performed on select patients taking anticoagulant and antiplatelet agents.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Anticoagulants; Aspirin; Bupivacaine; Clopidogrel; Conjunctiva; Female; Humans; Intraoperative Complications; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Suture Techniques; Ticlopidine; Treatment Outcome; Visual Acuity; Vitrectomy; Warfarin | 2012 |
Predictors and time trends in clopidogrel and proton pump inhibitor coprescription with low-dose acetylsalicylic acid.
Topics: Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Primary Health Care; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors; United Kingdom | 2012 |
No association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Vessel Prosthesis Implantation; Clopidogrel; Coronary Vessels; DNA Mutational Analysis; Drug-Eluting Stents; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Postoperative Complications; Risk; Thrombosis; Ticlopidine | 2012 |
[Pharmacoeconomic analysis of dabigatran etexilate effectiveness in patients with nonvalvular atrial fibrillation].
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Benzimidazoles; Blood Coagulation; Blood Coagulation Tests; Clopidogrel; Costs and Cost Analysis; Dabigatran; Humans; Insurance, Pharmaceutical Services; Models, Statistical; Outcome and Process Assessment, Health Care; Pyridines; Russia; Thromboembolism; Ticlopidine | 2012 |
Dual non-responsiveness to antiplatelet treatment is a stronger predictor of cardiac adverse events than isolated non-responsiveness to clopidogrel or aspirin.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Ticlopidine; Treatment Outcome | 2013 |
Different effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Famotidine; Humans; Oxidoreductases, N-Demethylating; Proton Pump Inhibitors; Recombinant Proteins; Ticlopidine | 2012 |
Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Topics: Administration, Oral; Anticoagulants; Aspirin; Atrial Fibrillation; Atrial Flutter; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electric Countershock; Evidence-Based Medicine; Fibrinolytic Agents; Hemorrhage; Humans; International Normalized Ratio; Risk Factors; Societies, Medical; Stroke; Ticlopidine; Vitamin K | 2012 |
Is there a clinically significant interaction between calcium channel antagonists and clopidogrel?: results from the Clopidogrel for the Reduction of Events During Observation (CREDO) trial.
Topics: Aged; Antihypertensive Agents; Calcium Channel Blockers; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP3A; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Survival Analysis; Ticlopidine | 2012 |
[The GRAVITAS study].
Topics: Algorithms; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Drug-Eluting Stents; Humans; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Revascularization; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Care; Randomized Controlled Trials as Topic; Research Design; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
[Perioperative management of antiplatelet therapy in thoracic surgery. A survey of German hospitals].
Topics: Arterial Occlusive Diseases; Aspirin; Attitude of Health Personnel; Brain Ischemia; Clopidogrel; Combined Modality Therapy; Data Collection; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Germany; Humans; Myocardial Infarction; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Stents; Surveys and Questionnaires; Thoracic Surgical Procedures; Ticlopidine | 2012 |
eComment. Impact of clopidogrel on bleeding complications and survival in off-pump coronary artery bypass grafting.
Topics: Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Restenosis; Female; Humans; Male; Postoperative Hemorrhage; Ticlopidine | 2012 |
Acute stent thrombosis: technical complication or inadequate antithrombotic therapy? An optical coherence tomography study.
Topics: Acute Disease; Aged; Antithrombins; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Eptifibatide; Female; Fibrinolytic Agents; Heparin; Hirudins; Humans; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Recombinant Proteins; Risk Factors; Ticlopidine; Tomography, Optical Coherence | 2012 |
Cardiovascular outcomes associated with concomitant use of clopidogrel and proton pump inhibitors in patients with acute coronary syndrome in Taiwan.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Humans; Male; Middle Aged; Patient Readmission; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk; Stents; Taiwan; Ticlopidine | 2012 |
Combined antithrombotic treatment with aspirin and clopidogrel for patients with capsular warning syndrome: a case report.
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Internal Capsule; Intracranial Thrombosis; Ischemic Attack, Transient; Male; Middle Aged; Ticlopidine | 2012 |
Clopidogrel and the risk of osteoporotic fractures: a nationwide cohort study.
Topics: Aged; Clopidogrel; Cohort Studies; Female; Humans; Male; Osteoporotic Fractures; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2012 |
Spontaneous remission after a year of romiplostim in an adult patient with refractory primary immune thrombocytopenia.
Topics: Antibodies, Monoclonal, Murine-Derived; Anticoagulants; Aspirin; Clopidogrel; Drug Resistance; Hemorrhage; Humans; Immunization, Passive; Male; Metabolic Syndrome; Middle Aged; Myocardial Infarction; Prednisone; Purpura, Thrombocytopenic, Idiopathic; Receptors, Fc; Recombinant Fusion Proteins; Remission, Spontaneous; Rituximab; Stents; Thrombopoiesis; Thrombopoietin; Ticlopidine | 2012 |
Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response.
Topics: Adolescent; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Enzyme Inhibitors; Humans; Midazolam; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Young Adult | 2012 |
Management of a hypersensitivity reaction to thienopyridines: prasugrel-induced fever and hepatitis resolved after switching to clopidogrel.
Topics: Adult; Clopidogrel; Coronary Artery Disease; Drug Hypersensitivity; Female; Fever; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2012 |
Serotonin antagonism improves platelet inhibition in clopidogrel low-responders after coronary stent placement: an in vitro pilot study.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; In Vitro Techniques; Ketanserin; Light; Male; Middle Aged; Myocardial Infarction; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Serotonin Antagonists; Stents; Ticlopidine; Treatment Outcome | 2012 |
Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Diabetes Mellitus; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticlopidine | 2013 |
High on-treatment platelet reactivity by ADP and increased risk of MACE in good clopidogrel metabolizers.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Heparin; Heterozygote; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk; Survival Rate; Ticlopidine | 2012 |
Prasugrel as a safe alternative for clopidogrel-induced polyarthralgias.
Topics: Arthralgia; Clopidogrel; Humans; Male; Middle Aged; Piperazines; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2012 |
Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
Topics: Aged; Angioplasty; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Blood Chemical Analysis; Clopidogrel; Coronary Angiography; Female; Heart Failure; Hospital Mortality; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Peroxidase; Predictive Value of Tests; Prospective Studies; ROC Curve; Ticlopidine; Time Factors; Troponin I | 2012 |
Perioperative clopidogrel and postoperative events after hip and knee arthroplasties.
Topics: Age Factors; Aged; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Clopidogrel; Databases, Factual; Drug Administration Schedule; Female; Humans; Male; Perioperative Period; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Retrospective Studies; Risk Factors; Survival Rate; Ticlopidine | 2012 |
Late peripheral stent thrombosis due to stent fracture, vigorous exercise and hyporesponsiveness to clopidogrel.
Topics: Aged; Angioplasty; Arterial Occlusive Diseases; Bicycling; Clopidogrel; Constriction, Pathologic; Drug Resistance; Exercise; Femoral Artery; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Prosthesis Design; Prosthesis Failure; Radiography; Risk Factors; Stents; Thrombolytic Therapy; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Coronary artery bypass graft surgery in acute coronary syndrome: incidence, cost impact, and acute clopidogrel interruption.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Artery Bypass; Female; Hemorrhage; Hospital Costs; Hospitalization; Humans; Incidence; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; United States | 2012 |
Antiplatelet therapy: Does CYP2C19 genotype affect clinical outcome?
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Evidence-Based Medicine; Genotype; Humans; Patient Selection; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Fibrinolytic Agents; Genetic Testing; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Thrombosis; Ticlopidine | 2012 |
Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents?: the role of platelet reactivity and genotype testing in the prevention of atherothrombotic cardiovascular events remains unproven.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Fibrinolytic Agents; Genetic Testing; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Platelet Function Tests; Prevalence; Prognosis; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Thrombosis; Ticlopidine | 2012 |
The FDA outlook of events reporting after ticagrelor or clopidogrel in the PLATO Trial: impact of sponsor censoring dates, drug discontinuation, and withdrawal of consent.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials, Phase III as Topic; Clopidogrel; Data Interpretation, Statistical; Disclosure; Humans; Informed Consent; Multicenter Studies as Topic; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Reproducibility of Results; Research Design; Research Support as Topic; Selection Bias; Ticagrelor; Ticlopidine; Treatment Refusal; United States; United States Food and Drug Administration | 2011 |
A screening study of drug-drug interactions in cerivastatin users: an adverse effect of clopidogrel.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Case-Control Studies; Clopidogrel; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation Inhibitors; Pyridines; Rhabdomyolysis; Ticlopidine | 2012 |
Aneurysm formation after drug-eluting balloon treatment of drug-eluting in-stent restenosis: first case report.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Aspirin; Cardiac Catheters; Cardiovascular Agents; Clopidogrel; Coronary Aneurysm; Coronary Angiography; Coronary Restenosis; Drug Delivery Systems; Drug Therapy, Combination; Drug-Eluting Stents; Equipment Design; Humans; Male; Middle Aged; Paclitaxel; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2012 |
Absorption enhancement studies of clopidogrel hydrogen sulphate in rat everted gut sacs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Clopidogrel; Dose-Response Relationship, Drug; Excipients; Flavanones; Intestinal Absorption; Jejunum; Male; Platelet Aggregation Inhibitors; Quinidine; Rats; Rats, Wistar; Solubility; Tartrates; Ticlopidine | 2012 |
A high loading dose of clopidogrel reduces myocardial infarct size in patients undergoing primary percutaneous coronary intervention: a magnetic resonance imaging study.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial Infarction; Myocardium; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2012 |
Multicolor flow cytometry for evaluation of platelet surface antigens and activation markers.
Topics: Aspirin; Blood Platelets; Clopidogrel; Flow Cytometry; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombasthenia; Thrombocytopenia; Ticlopidine | 2012 |
Association of estimated GFR with platelet inhibition in patients treated with clopidogrel.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Clopidogrel; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Renal Insufficiency; Risk Assessment; Severity of Illness Index; Ticlopidine; Treatment Outcome | 2012 |
The effect of the CYP 2C19*2 polymorphism on stroke care.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Heterozygote; Homozygote; Humans; Hungary; Male; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stroke; Ticlopidine | 2012 |
[Optimal antiplatelet and antithrombotic therapy in patients with ST elevation myocardial infarction].
Topics: Abciximab; Adenosine; Antibodies, Monoclonal; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
[Letter to Kardiologia Polska concerning optimal treatment of myocardial infarction].
Topics: Adenosine; Clopidogrel; Cost-Benefit Analysis; Humans; Models, Theoretical; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Hemostasis; Mice; Mice, Knockout; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Proteinase-Activated; Thrombosis; Ticlopidine | 2012 |
The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro.
Topics: Antibodies, Monoclonal; Aryldialkylphosphatase; Chromatography, Liquid; Clopidogrel; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Genotype; Humans; Microsomes; Microsomes, Liver; Molecular Structure; Tandem Mass Spectrometry; Ticlopidine | 2012 |
Overcoming clopidogrel resistance: discovery of vicagrel as a highly potent and orally bioavailable antiplatelet agent.
Topics: Administration, Oral; Animals; Biological Availability; Clopidogrel; Drug Resistance; Female; In Vitro Techniques; Male; Mice; Microsomes, Liver; Phenylacetates; Platelet Aggregation Inhibitors; Prodrugs; Rats; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Ticlopidine | 2012 |
Platelet transfusion for reversal of dual antiplatelet therapy in patients requiring urgent surgery: a pilot study.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Emergencies; Emergency Medical Services; Female; Germany; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Platelet Transfusion; Postoperative Hemorrhage; Preoperative Care; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2012 |
Clopidogrel increases bleeding complications in patients undergoing heart rhythm device procedures.
Topics: Cardiac Resynchronization Therapy; Case-Control Studies; Clopidogrel; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Female; France; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Are the results of a regional ST-elevation myocardial infarction system reproducible?
Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clinical Protocols; Clopidogrel; Databases, Factual; Female; Fibrinolytic Agents; Heparin; Hospital Mortality; Humans; Iowa; Male; Middle Aged; Minnesota; Myocardial Infarction; Outcome and Process Assessment, Health Care; Platelet Aggregation Inhibitors; Prospective Studies; Regional Medical Programs; Tenecteplase; Ticlopidine; Time Factors; Tissue Plasminogen Activator; Transportation of Patients | 2012 |
Cigarette smoking is associated with a dose-response effect in clopidogrel-treated patients with diabetes mellitus and coronary artery disease: results of a pharmacodynamic study.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Cotinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Florida; Humans; Male; Microfilament Proteins; Middle Aged; Odds Ratio; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Smoking; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Reducing co-administration of clopidogrel and proton pump inhibitors in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Algorithms; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Guideline Adherence; Humans; Medical Audit; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prescriptions; Proton Pump Inhibitors; Retrospective Studies; Ticlopidine | 2012 |
The effects of clopidogrel (Plavix) and other oral anticoagulants on early hip fracture surgery.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Cohort Studies; Female; Hip Fractures; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome; Warfarin | 2012 |
Comparison of early outcomes after primary stenting in Japanese patients with acute myocardial infarction between clopidogrel and ticlopidine in concomitant use with proton-pump inhibitor.
Topics: Aged; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2012 |
Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction.
Topics: Aged; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Antihypertensive Agents; Aspirin; Biomarkers; C-Reactive Protein; Clopidogrel; Female; Heparin; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Perindopril; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Ventricular Dysfunction, Left | 2012 |
Bridging with glycoprotein IIb/IIIa inhibitors for periprocedural management of antiplatelet therapy in patients with drug eluting stents.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Cardiac Surgical Procedures; Clopidogrel; Drug Administration Schedule; Drug Substitution; Drug-Eluting Stents; Eptifibatide; Female; Humans; Male; Middle Aged; Minnesota; Patient Selection; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Postoperative Hemorrhage; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
A case of acute coronary artery occlusion associated with very rapid onset heparin-induced thrombosis without thrombocytopenia.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Arginine; Aspirin; Autoantibodies; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Occlusion; Drug Therapy, Combination; Female; Heart Failure; Heparin; Humans; Pipecolic Acids; Platelet Count; Platelet Factor 4; Stents; Sulfonamides; Tetrazoles; Thrombosis; Ticlopidine; Time Factors | 2012 |
A risk-benefit assessment of prasugrel, clopidogrel, and genotype-guided therapy in patients undergoing percutaneous coronary intervention.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Probability; Risk Assessment; Thiophenes; Ticlopidine | 2012 |
Laser-induced thrombus formation in mouse brain microvasculature: effect of clopidogrel.
Topics: Animals; Blood Platelets; Brain; Cerebral Arteries; Clopidogrel; Intracranial Thrombosis; Lasers; Mice; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Federal court invalidates Sanofi's Plavix patent for alleged insufficiency and obviousness.
Topics: Canada; Clopidogrel; Humans; Legislation, Drug; Patents as Topic; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependent on clopidogrel response.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, PAR-1; Receptors, Thrombin; Thrombosis; Ticlopidine | 2012 |
Adverse cardiovascular outcomes associated with concurrent use of clopidogrel or ticlopidine and proton-pump inhibitors in patients undergoing percutaneous coronary intervention.
Topics: Aged; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Coronary Stenosis; Disease-Free Survival; Drug Interactions; Female; Hospitals, University; Humans; Japan; Kaplan-Meier Estimate; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polypharmacy; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Interactions; Famotidine; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Male; Omeprazole; Peroxidase; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Ticlopidine | 2012 |
Cost is not a barrier to implementing clopidogrel pharmacogenetics.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombolytic Therapy; Ticlopidine | 2012 |
Cost-effectiveness of cytochrome P450 2C19 genotype screening for selection of antiplatelet therapy with clopidogrel or prasugrel.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Computer Simulation; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Decision Trees; Drugs, Generic; Genotype; Hemorrhage; Humans; Models, Economic; Models, Statistical; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombolytic Therapy; Ticlopidine | 2012 |
CYP2C19 and PON1 polymorphisms regulating clopidogrel bioactivation in Chinese, Malay and Indian subjects.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Asian People; China; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; India; Malaysia; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine; White People | 2012 |
Comparison of additional versus no additional heparin during therapeutic oral anticoagulation in patients undergoing percutaneous coronary intervention.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Fibrinolytic Agents; Follow-Up Studies; Heparin; Humans; Injections, Subcutaneous; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Preoperative Care; Prospective Studies; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2012 |
Suboptimal response to clopidogrel and the effect of prasugrel in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; New Zealand; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Computed tomography angiography evaluation of internal carotid artery free-floating thrombus--single-center diagnosis, false-positives, and follow-up.
Topics: Aged; Anticoagulants; Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Clopidogrel; Diagnosis, Differential; Female; Fibrinolytic Agents; Heparin; Humans; Male; Thrombosis; Ticlopidine; Tissue Plasminogen Activator; Tomography, X-Ray Computed | 2012 |
Effects of PPIs and an H2 blocker on the antiplatelet function of clopidogrel in Japanese patients under dual antiplatelet therapy.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Asian People; Aspirin; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Drug Therapy, Combination; Enzyme Inhibitors; Female; Histamine H2 Antagonists; Humans; Male; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Proton Pump Inhibitors; Rabeprazole; Ticlopidine | 2012 |
Individualised PPI prescription in patients on combination antiplatelet therapy and upper gastrointestinal events after percutaneous coronary intervention: a cohort study.
Topics: Acute Coronary Syndrome; Adrenal Cortex Hormones; Adverse Drug Reaction Reporting Systems; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cohort Studies; Combined Modality Therapy; Coronary Angiography; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Peptic Ulcer; Platelet Aggregation Inhibitors; Precision Medicine; Proton Pump Inhibitors; Ticlopidine | 2012 |
Counterintuitive compaction behavior of clopidogrel bisulfate polymorphs.
Topics: Clopidogrel; Crystallization; Models, Chemical; Platelet Aggregation Inhibitors; Porosity; Tablets; Tensile Strength; Ticlopidine; X-Ray Diffraction | 2012 |
Erratum for Fernandez et al. “Comparison of adverse cardiovascular events and bleeding complications of loading dose of clopidogrel 300 mg versus 600 mg in stable patients undergoing elective percutaneous intervention (from the CADICE Study)” Am J Cardiol
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Dose-Response Relationship, Drug; Elective Surgical Procedures; Hemorrhage; Humans; Incidence; Platelet Aggregation Inhibitors; Preoperative Care; Risk Factors; Thrombosis; Ticlopidine; United States | 2012 |
Clinical and pathological improvement in stroke-prone spontaneous hypertensive rats related to the pleiotropic effect of cilostazol.
Topics: Animals; Aspirin; Biomarkers; Cerebral Infarction; Cilostazol; Clopidogrel; Hippocampus; Male; Nerve Tissue Proteins; Oxidative Stress; Platelet Aggregation Inhibitors; Rats; Rats, Inbred SHR; Receptor, IGF Type 1; Tetrazoles; Ticlopidine | 2012 |
Maintenance of anticoagulant and antiplatelet agents for patients undergoing peribulbar anesthesia and vitreoretinal surgery.
Topics: Acenocoumarol; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anticoagulants; Aspirin; Clopidogrel; Conscious Sedation; Electrocardiography; Eye Hemorrhage; Female; Humans; Male; Middle Aged; Orbit; Oximetry; Phenindione; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Ticlopidine; Vitreoretinal Surgery; Warfarin; Young Adult | 2012 |
Impaired responsiveness to clopidogrel and aspirin in patients with recurrent stent thrombosis following percutaneous intervention for peripheral artery disease.
Topics: Aged; Angioplasty; Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2013 |
Paraoxonase 1 Q192R variant and clopidogrel efficacy: fact or fiction?
Topics: Angina, Unstable; Aryldialkylphosphatase; Atrial Fibrillation; Clopidogrel; Female; Humans; Male; Polymorphism, Single Nucleotide; Ticlopidine | 2012 |
Transient increase in pressure gradients after termination of dual antiplatelet therapy in a patient after transfemoral aortic valve implantation.
Topics: Aged; Aortic Valve Stenosis; Aspirin; Cardiac Catheterization; Clopidogrel; Dyspnea; Echocardiography, Doppler; Femoral Artery; Heart Valve Prosthesis Implantation; Hemodynamics; Humans; Male; Platelet Aggregation Inhibitors; Recovery of Function; Ticlopidine; Withholding Treatment | 2012 |
Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Aspirin; Carboxylic Ester Hydrolases; Clopidogrel; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hydrolysis; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; Naphthaleneacetic Acids; Phenobarbital; Ticlopidine | 2012 |
Using models to predict the future: what to do when the data run out?
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2012 |
The need for translational research on drug-drug interactions.
Topics: Clopidogrel; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation Inhibitors; Pyridines; Ticlopidine | 2012 |
Clopidogrel: a case for indication-specific pharmacogenetics.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Triple antithrombotic therapy after coronary stenting in the elderly with atrial fibrillation: necessary or too hazardous?
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Warfarin | 2012 |
Safety and effectiveness of antithrombotic strategies in older adult patients with atrial fibrillation and non-ST elevation myocardial infarction.
Topics: Aged; Aged, 80 and over; Aspirin; Atrial Fibrillation; Clopidogrel; Comorbidity; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Medicare; Myocardial Infarction; Patient Readmission; Proportional Hazards Models; Registries; Ticlopidine; Treatment Outcome; United States; Warfarin | 2012 |
Dual antiplatelet therapy after myocardial infarction and percutaneous coronary intervention: analysis of patient adherence using a French health insurance reimbursement database.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cohort Studies; Databases, Factual; Drug Therapy, Combination; Female; France; Humans; Insurance, Health, Reimbursement; Male; Myocardial Infarction; Patient Compliance; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2012 |
Short thromboelastography and the identification of high platelet reactivity while on and off therapy.
Topics: Clopidogrel; Coronary Thrombosis; Drug Resistance; Female; Graft Occlusion, Vascular; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Registries; Ticlopidine | 2012 |
Personalised antiplatelet therapy in stent thrombosis: observations from the Clopidogrel Resistance in Stent Thrombosis (CREST) registry.
Topics: Aged; Aspirin; Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Resistance; Electrocardiography; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prevalence; Prospective Studies; Registries; Thrombelastography; Ticlopidine; Treatment Outcome; United Kingdom | 2012 |
Clopidogrel response up to six months after acute myocardial infarction.
Topics: Aspirin; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors | 2012 |
Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Animals; Clinical Protocols; Clopidogrel; Electrocardiography; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Risk Factors; Ticlopidine | 2012 |
[Resistance to antiplatelet agents assessed by a point-of-care platelet function test and thromboembolic adverse events in neurointervention].
Topics: Adult; Aged; Aspirin; Cilostazol; Clopidogrel; Drug Resistance; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Tetrazoles; Thromboembolism; Ticlopidine | 2012 |
[Impact of clopidogrel on gene profile of human umbilical vein endothelial cell line and bioinformatics analysis].
Topics: Cell Line; Clopidogrel; Human Umbilical Vein Endothelial Cells; Humans; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Ticlopidine; Transcription, Genetic; Transcriptome | 2012 |
[Effect of clopidogrel combined with calcium-channel blocker on coronary artery disease in elderly patients: a propensity score-based retrospective cohort study].
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Clopidogrel; Cohort Studies; Coronary Artery Disease; Drug Therapy, Combination; Humans; Middle Aged; Propensity Score; Retrospective Studies; Ticlopidine | 2012 |
Pharmacogenetics: Point-of-care genetic testing--a new frontier explored.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Genotype; Humans; Patient Selection; Pharmacogenetics; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Precision Medicine; Predictive Value of Tests; Risk Assessment; Risk Factors; Ticlopidine | 2012 |
Effect of glycemic control on response to antiplatelet therapy in patients with diabetes mellitus and ST-segment elevation myocardial infarction.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Blood Glucose; Clopidogrel; Diabetic Cardiomyopathies; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2012 |
Multiple gene polymorphisms predisposing to the prothrombotic state in an adolescent with acute myocardial infarction.
Topics: Adolescent; Anticoagulants; Aspirin; Cholesterol Ester Transfer Proteins; Clopidogrel; Coronary Angiography; Electrocardiography; Fibrinogen; Genetic Predisposition to Disease; Heparin; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2012 |
Very late thrombosis of a paclitaxel-eluting stent after 72 months in a patient on dual anti-platelet therapy.
Topics: Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Echocardiography; Electrocardiography; Humans; Male; Middle Aged; Myocardial Infarction; Paclitaxel; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2012 |
Clopidogrel load for emboli reduction in patients with symptomatic carotid stenosis undergoing urgent carotid endarterectomy.
Topics: Aged; Carotid Stenosis; Clopidogrel; Emergency Treatment; Endarterectomy, Carotid; Female; Humans; Intracranial Embolism; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Ultrasonography | 2012 |
Utility of VasoCT in the treatment of intracranial aneurysm with flow-diverter stents.
Topics: Adult; Aged; Angiography, Digital Subtraction; Angioplasty, Balloon; Aspirin; Catheterization; Cerebral Angiography; Cerebral Arteries; Clopidogrel; Female; Fluoroscopy; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Intracranial Aneurysm; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine; Tomography, X-Ray Computed | 2012 |
Clopidogrel use before renal artery angioplasty with/without stent placement resulted in tertiary procedure risk reduction.
Topics: Aged; Angioplasty, Balloon; Aspirin; Clopidogrel; Comorbidity; Female; Humans; Life Tables; Male; Platelet Aggregation Inhibitors; Renal Artery Obstruction; Retreatment; Secondary Prevention; Stents; Ticlopidine | 2012 |
Do we have to stop anticoagulant and platelet-inhibitor treatments during proctological surgery?
Topics: Adult; Anticoagulants; Aspirin; Blood Transfusion; Chi-Square Distribution; Clopidogrel; Female; Hemorrhoids; Heparin; Humans; Male; Middle Aged; Multivariate Analysis; Patient Readmission; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Rectal Neoplasms; Ticlopidine | 2012 |
The effect of antiplatelet therapy in patients with inflammatory bowel disease.
Topics: Aspirin; Clopidogrel; Disease Progression; Female; Humans; Inflammatory Bowel Diseases; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2012 |
Pharmacokinetic interactions between clopidogrel and rosuvastatin: effects on vascular protection in subjects with coronary heart disease.
Topics: Cardiovascular Diseases; Clopidogrel; Coronary Disease; Drug Interactions; Female; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyrimidines; Rosuvastatin Calcium; Sulfonamides; Ticlopidine | 2012 |
Clopidogrel use and hospital quality in medically managed patients with non-ST-segment-elevation myocardial infarction.
Topics: Aged; Aged, 80 and over; Chi-Square Distribution; Clopidogrel; Drug Utilization; Female; Guideline Adherence; Hospitals; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Patient Discharge; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Quality Indicators, Health Care; Registries; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; United States | 2012 |
Enhanced clopidogrel response in smokers is reversed after discontinuation as assessed by VerifyNow assay: additional evidence for the concept of 'smokers' paradox'.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Angiography; Drug Resistance; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Smoking; Smoking Cessation; Ticlopidine; Treatment Outcome | 2012 |
Comparison of bolus only with bolus plus infusion of bivalirudin in patients undergoing elective percutaneous coronary intervention: a retrospective observational study.
Topics: Aged; Alabama; Antithrombins; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Elective Surgical Procedures; Female; Hemorrhage; Hirudins; Humans; Incidence; Infusions, Intravenous; Injections, Intravenous; Ischemia; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recombinant Proteins; Retrospective Studies; Severity of Illness Index; Thrombosis; Ticlopidine | 2012 |
Beware of novel antiplatelet therapy in acute coronary syndrome patients with previous stroke.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Male; Stroke; Ticagrelor; Ticlopidine | 2012 |
Dramatic effect of early clopidogrel administration in reducing mortality and MACE rates in ACS patients. Data from the Swiss registry AMIS-Plus.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Aspirin; Cardiac Catheterization; Clopidogrel; Confidence Intervals; Drug Therapy, Combination; Electrocardiography; Female; Hospital Mortality; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Registries; Switzerland; Ticlopidine; Time Factors; Young Adult | 2012 |
Blood loss and complications following carotid endarterectomy in patients treated with clopidogrel.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carotid Artery Diseases; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Hematoma; Humans; Israel; Male; Middle Aged; Peripheral Nerve Injuries; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Assessment; Risk Factors; Stroke; Surgical Wound Infection; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Peribulbar block in patients scheduled for eye procedures and treated with clopidogrel.
Topics: Aged; Anesthesia, Local; Case-Control Studies; Clopidogrel; Eye Hemorrhage; Humans; Nerve Block; Ophthalmologic Surgical Procedures; Prospective Studies; Ticlopidine | 2012 |
Prasugrel: a guide to its use in patients with acute coronary syndromes undergoing percutaneous coronary intervention in the US.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clinical Trials as Topic; Clopidogrel; Economics, Pharmaceutical; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; United States | 2012 |
Formation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomes.
Topics: Clopidogrel; Dose-Response Relationship, Drug; Glutathione; Humans; Microsomes, Liver; Oxidation-Reduction; Sulfhydryl Compounds; Ticlopidine | 2012 |
Peripartum management of dual antiplatelet therapy and neuraxial labor analgesia after bare metal stent insertion for acute myocardial infarction.
Topics: Adult; Analgesia, Obstetrical; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Eptifibatide; Female; Humans; Metals; Myocardial Infarction; Nerve Block; Peptides; Peripartum Period; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications; Stents; Ticlopidine | 2012 |
Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project.
Topics: Aryl Hydrocarbon Hydroxylases; Cardiac Catheterization; Clopidogrel; Computer-Aided Design; Cytochrome P-450 CYP2C19; Decision Support Systems, Clinical; Genetic Variation; Genotyping Techniques; Humans; Patient Selection; Pharmacogenetics; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine | 2012 |
Rapid testing of clopidogrel resistance by genotyping of CYP2C19 and CYP2C9 polymorphisms using denaturing on-chip capillary electrophoresis.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Resistance; Electrophoresis, Microchip; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Reproducibility of Results; Ticlopidine | 2012 |
High platelet reactivity on clopidogrel therapy correlates with increased coronary atherosclerosis and calcification: a volumetric intravascular ultrasound study.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Drug Resistance; Female; Humans; Least-Squares Analysis; Linear Models; Male; Middle Aged; Multivariate Analysis; New York City; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Risk Assessment; Risk Factors; Severity of Illness Index; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Interventional; Vascular Calcification | 2012 |
[ST segment elevation-acute myocardial infarction management at the office: clopidogrel or aspirin?].
Topics: Aged; Anterior Wall Myocardial Infarction; Aspirin; Choice Behavior; Clopidogrel; Electrocardiography; Female; Humans; Physicians' Offices; Platelet Aggregation Inhibitors; Referral and Consultation; Ticlopidine | 2012 |
Major adverse cardiac events among postpercutaneous coronary intervention patients on clopidogrel and proton pump inhibitors.
Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2012 |
Pharmacodynamic effect of clopidogrel therapy and switching to cilostazol in patients with the CYP2C19 loss-of-function allele (ACCEL-SWITCH) study.
Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Cilostazol; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Substitution; Drug Therapy, Combination; Drug-Eluting Stents; Genotype; Heterozygote; Homozygote; Humans; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Republic of Korea; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Role of the laboratory in monitoring patients receiving dual antiplatelet therapy.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Aspirin; Clinical Laboratory Techniques; Clopidogrel; Drug Resistance; Female; Humans; Logistic Models; Male; Middle Aged; Monitoring, Physiologic; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Reproducibility of Results; Sensitivity and Specificity; Stents; Thrombosis; Ticlopidine | 2012 |
Blockbuster interactions: are they bad for the patient?
Topics: Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP3A; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
[Comparison on the effects of clopidogrel, statins combination in treating coronary artery disease among the elderly patients: a retrospective cohort study].
Topics: Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Retrospective Studies; Ticlopidine | 2012 |
Duration of dual antiplatelet therapy and long-term clinical outcome after coronary drug-eluting stent implantation: landmark analyses from the CREDO-Kyoto PCI/CABG Registry Cohort-2.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Chi-Square Distribution; Clopidogrel; Cohort Studies; Coronary Artery Disease; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Japan; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prosthesis Design; Pyridines; Registries; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
The perioperative management of patients with coronary artery stents: surveying the clinical stakeholders and arriving at a consensus regarding optimal care.
Topics: Adult; Advisory Committees; Alabama; Anesthesiology; Aspirin; Blood Loss, Surgical; Cardiac Catheterization; Cardiology; Clopidogrel; Consensus; Coronary Vessels; Cross-Sectional Studies; Decision Making; Decision Support Techniques; Female; General Surgery; Health Care Surveys; Humans; Male; Middle Aged; Myocardial Ischemia; Perioperative Care; Perioperative Period; Physicians; Platelet Aggregation Inhibitors; Primary Health Care; Risk Factors; Sampling Studies; Stents; Surveys and Questionnaires; Thrombosis; Ticlopidine; Workforce | 2012 |
[Omega-3--clopidogrel can help!].
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Fatty Acids, Omega-3; Female; Humans; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2012 |
Differential inhibitory effects of proton pump inhibitors on the metabolism and antiplatelet activities of clopidogrel and prasugrel.
Topics: Clopidogrel; Drug Interactions; Humans; In Vitro Techniques; Microsomes, Liver; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prasugrel Hydrochloride; Proton Pump Inhibitors; Thiophenes; Ticlopidine | 2012 |
Immediate and delayed traumatic intracranial hemorrhage in patients with head trauma and preinjury warfarin or clopidogrel use.
Topics: Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Craniocerebral Trauma; Emergency Service, Hospital; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Risk; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Warfarin | 2012 |
Validation of the dime.
Topics: Anticoagulants; Clopidogrel; Craniocerebral Trauma; Female; Humans; Intracranial Hemorrhages; Male; Platelet Aggregation Inhibitors; Ticlopidine; Warfarin | 2012 |
Simultaneous subacute thrombosis of bare metal coronary stents in two different arteries early after clopidogrel cessation.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Drug Administration Schedule; Electrocardiography; Female; Humans; Medication Adherence; Metals; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Design; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Evaluation of the role of the new INNOVANCE PFA P2Y test cartridge in detection of clopidogrel resistance.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Platelets; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Longitudinal Studies; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombosis; Ticlopidine | 2012 |
Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites.
Topics: Cell Survival; Clopidogrel; Colony-Forming Units Assay; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Humans; Myeloid Progenitor Cells; Peroxidase; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Fractalkine activates a signal transduction pathway similar to P2Y12 and is associated with impaired clopidogrel responsiveness.
Topics: Adenosine Diphosphate; Alprostadil; Chemokine CX3CL1; Clopidogrel; Coronary Artery Disease; Humans; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Ticlopidine | 2012 |
Ticagrelor in clopidogrel-resistant patients undergoing maintenance hemodialysis.
Topics: Adenosine; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Drug Resistance; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Purinergic P2Y Receptor Antagonists; Renal Dialysis; Ticagrelor; Ticlopidine | 2012 |
Economic evaluation of clopidogrel in acute coronary syndrome patients without ST-segment elevation in Greece: a cost-utility analysis.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Clopidogrel; Computer Simulation; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Greece; Humans; Male; Markov Chains; Models, Economic; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Secondary Prevention; Survival Analysis; Ticlopidine | 2012 |
Prolonged clopidogrel use after bare metal and drug-eluting stent placement: the Veterans Administration drug-eluting stent study.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Logistic Models; Male; Metals; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Prosthesis Design; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome; United States; United States Department of Veterans Affairs | 2012 |
Clopidogrel-induced ageusia: a possible overlooked etiology by dentists?
Topics: Aged, 80 and over; Ageusia; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Smoking, atherothrombosis and clopidogrel.
Topics: Blood Platelets; Clopidogrel; Drug Resistance; Female; Humans; Male; Myocardial Ischemia; Platelet Activation; Smoking; Smoking Cessation; Ticlopidine | 2012 |
Dual thienopyridine low-response to clopidogrel and prasugrel in a patient with STEMI, cardiogenic shock and early stent thrombosis is overcome by ticagrelor.
Topics: Adenosine; Aged; Cardiopulmonary Resuscitation; Clopidogrel; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Shock, Cardiogenic; Stents; Thiophenes; Thrombosis; Ticagrelor; Ticlopidine | 2012 |
Clinical pharmacogenomics of warfarin and clopidogrel.
Topics: Anticoagulants; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Humans; Mixed Function Oxygenases; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Vitamin K Epoxide Reductases; Warfarin | 2012 |
Risk of wound hematoma at carotid endarterectomy under dual antiplatelet therapy.
Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Hematoma; Humans; Male; Platelet Aggregation Inhibitors; Reoperation; Risk Factors; Ticlopidine | 2012 |
Platelet reactivity and percutaneous coronary intervention: another clue in the quest for the Holy Grail of tailored antithrombotic therapy?
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Clopidogrel; Female; Heparin; Hirudins; Humans; Immunoglobulin Fab Fragments; Male; Myocardial Infarction; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Recombinant Proteins; Stents; Ticlopidine | 2012 |
High post-clopidogrel platelet reactivity assessed by a point-of-care assay predicts long-term clinical outcomes in patients with ST-segment elevation myocardial infarction who underwent primary coronary stenting.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Stents; Ticlopidine; Treatment Outcome | 2013 |
Autocrine regulation of γ-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors.
Topics: Adenosine Triphosphate; Apyrase; Ataxia Telangiectasia Mutated Proteins; Autocrine Communication; Cell Cycle Proteins; Cell Line, Tumor; Clopidogrel; DNA Damage; DNA Repair; DNA-Binding Proteins; Extracellular Space; Gamma Rays; Histones; Humans; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Protein Serine-Threonine Kinases; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Receptors, Purinergic P2Y12; Tetrazoles; Thiourea; Ticlopidine; Tumor Suppressor p53-Binding Protein 1; Tumor Suppressor Proteins | 2012 |
Adherence to guidelines for the prescribing of double and triple combinations of antithrombotic agents.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Attitude of Health Personnel; Clopidogrel; Community Pharmacy Services; Comorbidity; Drug Interactions; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization Review; Female; Fibrinolytic Agents; Guideline Adherence; Health Care Surveys; Health Knowledge, Attitudes, Practice; Hemorrhage; Humans; Male; Middle Aged; Netherlands; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Retrospective Studies; Risk Assessment; Risk Factors; Surveys and Questionnaires; Ticlopidine; Vitamin K | 2014 |
Long-term successful percutaneous coronary intervention in factor VII deficiency.
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Stenosis; Diabetes Mellitus, Type 2; Factor VII Deficiency; Follow-Up Studies; Humans; Male; Middle Aged; Obesity, Morbid; Platelet Aggregation Inhibitors; Radiography; Risk Assessment; Stents; Thromboembolism; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
CYP2C19 genotype-guided antiplatelet therapy in a patient with clopidogrel resistance.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Resistance; Genotype; Humans; Male; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Ticlopidine; Treatment Outcome | 2012 |
Massive epistaxis in a patient with Eisenmenger syndrome: illustrating the clot-versus-bleed conundrum.
Topics: Adult; Aspirin; Clopidogrel; Eisenmenger Complex; Epistaxis; Female; Humans; Platelet Aggregation Inhibitors; Thrombocytopenia; Thrombosis; Ticlopidine | 2011 |
Management of acute upper gastrointestinal bleeding: summary of NICE guidance.
Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Blood Component Transfusion; Clopidogrel; Contraindications; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Lypressin; Peptic Ulcer Hemorrhage; Proton Pump Inhibitors; Resuscitation; Risk Assessment; Secondary Prevention; Terlipressin; Ticlopidine; United Kingdom; Vasoconstrictor Agents; Warfarin | 2012 |
Anticoagulant use and its effect on bleeding and complications in total knee arthroplasty.
Topics: Aged; Anticoagulants; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Clopidogrel; Elective Surgical Procedures; Female; Humans; Length of Stay; Male; Platelet Aggregation Inhibitors; Preoperative Care; Retrospective Studies; Ticlopidine; Warfarin | 2012 |
Clopidogrel, Turkey and a red herring?
Topics: Chemical and Drug Induced Liver Injury; Clopidogrel; Diagnosis, Differential; Hepatitis E; Humans; Male; Middle Aged; Ticlopidine; Travel; Turkey | 2011 |
Clopidogrel in atrial fibrillation: is there any justification now in the era of new anticoagulants?
Topics: Aspirin; Atrial Fibrillation; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Stroke; Ticlopidine | 2012 |
Relationship between cytochrome P450 2C19*17 genotype distribution, platelet aggregation and bleeding risk in patients with blood stasis syndrome of coronary artery disease treated with clopidogrel.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation; Ticlopidine | 2012 |
Need for pharmacogenomic information also for generic medications: recommendation of the European Society of Pharmacogenomics and Theranostics (ESPT).
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Consensus; Cytochrome P-450 CYP2C19; Drug Labeling; Drugs, Generic; Europe; France; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Societies, Medical; Ticlopidine | 2012 |
Impact of age and anticoagulation: need for neurosurgical intervention in trauma patients with mild traumatic brain injury.
Topics: Age Factors; Aged; Anticoagulants; Aspirin; Brain Injuries; Clopidogrel; Craniotomy; Decompressive Craniectomy; Glasgow Coma Scale; Humans; Intracranial Hemorrhages; Middle Aged; Retrospective Studies; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Warfarin | 2012 |
Clinical outcomes using a platelet function-guided approach for secondary prevention in patients with ischemic stroke or transient ischemic attack.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Proportional Hazards Models; Secondary Prevention; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome | 2012 |
Clopidogrel (Plavix), a P2Y12 receptor antagonist, inhibits bone cell function in vitro and decreases trabecular bone in vivo.
Topics: Alkaline Phosphatase; Animals; Azo Compounds; Biomarkers; Bone and Bones; Bone Density; Bone Resorption; Cell Count; Cell Survival; Cells, Cultured; Clopidogrel; Collagen; Cyclic AMP; Gene Expression Regulation; Intracellular Space; Mice; Osteoblasts; Osteoclasts; Osteogenesis; Purinergic P2Y Receptor Antagonists; Radiography; Receptors, Purinergic P2Y12; Solubility; Staining and Labeling; Ticlopidine | 2012 |
Rapid P2Y12 inhibition: still an unmet medical need.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Female; Heart Diseases; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Quinazolinones; Receptors, Purinergic P2Y12; Sulfonamides; Ticlopidine | 2012 |
Cardioprotection by clopidogrel in acute ST-elevated myocardial infarction patients: a retrospective analysis.
Topics: Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Ticlopidine | 2012 |
Clopidogrel resistance in North Indian patients of coronary artery disease and lack of its association with platelet ADP receptors P2Y1 and P2Y12 gene polymorphisms.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Haplotypes; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2013 |
Safety of temporary and permanent suspension of antiplatelet therapy after drug eluting stent implantation in contemporary "real-world" practice.
Topics: Aged; Analysis of Variance; Aspirin; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Health Status Indicators; Humans; Male; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Prospective Studies; Risk Assessment; Ticlopidine; Time Factors | 2012 |
Sequential ADP-stimulated light transmission and multiple electrode aggregometry in patients taking aspirin and clopidogrel after non ST-elevation myocardial infarction.
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reproducibility of Results; Ticlopidine | 2012 |
Treatment with aspirin or clopidogrel does not affect equine platelet expression of P selectin or platelet-neutrophil aggregates.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clopidogrel; Cross-Over Studies; Female; Flow Cytometry; Horses; Male; Neutrophils; P-Selectin; Platelet Aggregation; Random Allocation; Statistics, Nonparametric; Ticlopidine | 2012 |
Multiple comparisons of drug efficacy between subgroups defined by genetic polymorphisms.
Topics: Alleles; Angina, Unstable; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Pharmaceutical Preparations; Pharmacogenetics; Pharmacology; Polymorphism, Genetic; Ticlopidine | 2012 |
Glutaredoxin is involved in the formation of the pharmacologically active metabolite of clopidogrel from its GSH conjugate.
Topics: Biotransformation; Clopidogrel; Enzyme Inhibitors; Glutaredoxins; Glutathione; Humans; Kinetics; Liver; Microsomes, Liver; Models, Biological; Oxidation-Reduction; Platelet Aggregation Inhibitors; Prodrugs; Recombinant Proteins; Ticlopidine | 2012 |
Combined clopidogrel and aspirin treatment up to surgery increases the risk of postoperative myocardial infarction, blood loss and reoperation for bleeding in patients undergoing coronary artery bypass grafting.
Topics: Aged; Aspirin; Blood Transfusion; Chi-Square Distribution; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Reoperation; Retrospective Studies; Statistics, Nonparametric; Ticlopidine; United Kingdom | 2013 |
Amlodipine, clopidogrel and CYP3A5 genetic variability: effects on platelet reactivity and clinical outcomes after percutaneous coronary intervention.
Topics: Aged; Amlodipine; Angioplasty, Balloon, Coronary; Clopidogrel; Cytochrome P-450 CYP3A; Drug Interactions; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prospective Studies; Stroke; Ticlopidine | 2012 |
P2Y12 inhibitors in acute coronary syndromes: how do we choose the best drug for our patients?
Topics: Adenosine; Cardiovascular Diseases; Clopidogrel; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2012 |
The extent of P2Y12 inhibition by clopidogrel in diabetes mellitus patients with acute coronary syndrome is not related to glycaemic control: roles of white blood cell count and body weight.
Topics: Acute Coronary Syndrome; Aged; Body Weight; Clopidogrel; Diabetes Complications; Diabetes Mellitus; Female; Flow Cytometry; Glycated Hemoglobin; Humans; Inflammation; Leukocyte Count; Leukocytes; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Phosphorylation; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2012 |
Effect of the clopidogrel-proton pump inhibitor drug interaction on adverse cardiovascular events in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug Interactions; Female; Follow-Up Studies; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Regression Analysis; Retrospective Studies; Ticlopidine; Time Factors | 2012 |
Rehospitalization following percutaneous coronary intervention for commercially insured patients with acute coronary syndrome: a retrospective analysis.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug-Eluting Stents; Female; Hospital Costs; Humans; Length of Stay; Male; Managed Care Programs; Middle Aged; Myocardial Revascularization; Patient Readmission; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; United States | 2012 |
Switching patients from clopidogrel to prasugrel in acute coronary syndrome: effects of prasugrel loading dose on residual platelet reactivity.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2012 |
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B.
Topics: Analysis of Variance; Animals; Aspirin; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase 2; Hepatitis B, Chronic; Liver; Liver Neoplasms; Membrane Proteins; Mice; Mice, Transgenic; Platelet Aggregation Inhibitors; Real-Time Polymerase Chain Reaction; Ticlopidine | 2012 |
Effect of different anticoagulants on multiple electrode platelet aggregometry after clopidogrel and aspirin administration in patients undergoing coronary stent implantation: a comparison between citrate and hirudin.
Topics: Adenosine Diphosphate; Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Anticoagulants; Arachidonic Acid; Aspirin; Citric Acid; Clopidogrel; Female; Hirudins; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; ROC Curve; Sensitivity and Specificity; Stents; Ticlopidine | 2013 |
Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs.
Topics: Aspirin; Clopidogrel; Cohort Studies; Data Collection; Drug Interactions; Humans; Multivariate Analysis; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Research Design; Ticlopidine; Vascular Diseases | 2012 |
Prescribing proton pump inhibitors with clopidogrel.
Topics: Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2012 |
Perioperative management of a neurosurgical patient requiring antiplatelet therapy.
Topics: Aged; Aspirin; Cerebral Angiography; Clopidogrel; Humans; Intracranial Aneurysm; Intracranial Thrombosis; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Neurologic Examination; Neurosurgical Procedures; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Stents; Ticlopidine; Tomography, X-Ray Computed; Ventriculoperitoneal Shunt | 2012 |
[Clopidogrel-associated thrombotic thrombocytopenic purpura].
Topics: ADAM Proteins; Aged; Clopidogrel; Enzyme Activation; Humans; Male; Plasma Exchange; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Ticlopidine | 2012 |
Atrial fibrillation and acute myocardial infarction: antithrombotic therapy and outcomes.
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Comorbidity; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Patient Discharge; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Research Design; Risk Assessment; Stroke; Thiophenes; Ticlopidine; Treatment Outcome; Warfarin | 2012 |
Clopidogrel efficacy and cigarette smoking status.
Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP1A2; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk; Smoking; Stroke; Ticlopidine; Treatment Failure | 2012 |
Clopidogrel discontinuation after myocardial infarction and risk of thrombosis: a nationwide cohort study.
Topics: Adult; Aged; Clopidogrel; Denmark; Drug Administration Schedule; Epidemiologic Methods; Female; Graft Occlusion, Vascular; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Failure; Recurrence; Stents; Thrombosis; Ticlopidine; Withholding Treatment | 2012 |
Hepatocellular carcinoma: could antiplatelet drugs be used to prevent HBV-associated hepatocellular carcinoma?
Topics: Animals; Carcinoma, Hepatocellular; Chemoprevention; Clopidogrel; Disease Models, Animal; Disease Progression; Hepatitis B, Chronic; Humans; Liver Neoplasms; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Antiplatelet therapy in acute coronary syndromes: beyond aspirin and clopidogrel.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Cyclooxygenase Inhibitors; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2012 |
Double interruption of antiplatelet therapy and tirofiban "bridging" for lung cancer resection.
Topics: Acute Coronary Syndrome; Aged; Biopsy, Needle; Clopidogrel; Coronary Restenosis; Drug Administration Schedule; Drug Substitution; Drug-Eluting Stents; Humans; Lung; Lung Neoplasms; Platelet Aggregation Inhibitors; Retreatment; Ticlopidine; Tirofiban; Tyrosine | 2012 |
A comparison of INNOVANCE® PFA P2Y and VerifyNow P2Y12 assay for the assessment of clopidogrel resistance in patients undergoing percutaneous coronary intervention.
Topics: Adult; Aged; Aged, 80 and over; Cardiac Catheterization; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Statistics, Nonparametric; Ticlopidine | 2012 |
Use of medial branch blocks before radiofrequency ablation for lumbar facet joints.
Topics: Aged; Catheter Ablation; Clopidogrel; Contraindications; Humans; Low Back Pain; Lumbar Vertebrae; Male; Median Nerve; Nerve Block; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Zygapophyseal Joint | 2012 |
A potent alternative to clopidogrel emerges. Prasugrel appears to lower heart attack risk for patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Dosage Calculations; Hemorrhage; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2010 |
Is chest tube insertion with ultrasound guidance safe in patients using clopidogrel?
Topics: Aged; Chest Tubes; Clopidogrel; Contraindications; Dyspnea; Female; Humans; Male; Platelet Aggregation Inhibitors; Pleural Effusion; Respiratory Insufficiency; Retrospective Studies; Thoracostomy; Ticlopidine; Treatment Outcome; Ultrasonography, Interventional | 2012 |
Medium to long-term clinical outcomes with everolimus-eluting stents in real-life percutaneous coronary intervention.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Everolimus; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; New Zealand; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Sirolimus; Survival Analysis; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Practice observed.
Topics: Aged; Buttocks; Clopidogrel; Contusions; Drug Interactions; Female; Ginkgo biloba; Hematuria; Hemorrhage; Humans; Phytotherapy; Plant Preparations; Platelet Aggregation Inhibitors; Postmenopause; Self Medication; Thigh; Ticlopidine; Vaginal Diseases | 2012 |
[Residual platelet activity in patients managed with clopidogrel: clinical implications for the management of patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Platelet activation and microvascular injury in patients with ST-segment elevation myocardial infarction.
Topics: Clopidogrel; Comorbidity; Coronary Angiography; Electrocardiography; Female; Humans; Magnetic Field Therapy; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Vascular System Injuries | 2012 |
Isoflurane prevents acute lung injury through ADP-mediated platelet inhibition.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Animals; Blood Platelets; Clopidogrel; Fluorescent Antibody Technique; Isoflurane; Lung; Male; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Resuscitation; Shock, Hemorrhagic; Ticlopidine | 2012 |
Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism.
Topics: Anti-Bacterial Agents; Appetite Depressants; Aryl Hydrocarbon Hydroxylases; Asian People; Clarithromycin; Clopidogrel; Cyclobutanes; Cytochrome P-450 CYP2B6; Humans; Male; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Republic of Korea; Ticlopidine | 2013 |
Ticagrelor FDA approval issues revisited.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials, Phase III as Topic; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Approval; Hemorrhage; Humans; Multicenter Studies as Topic; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stroke; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2012 |
Combining aspirin and proton pump inhibitors: for whom the warning bell tolls?
Topics: Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2012 |
Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent).
Topics: Aldehydes; Amines; Catalysis; Clopidogrel; Magnetic Resonance Spectroscopy; Molecular Structure; Platelet Aggregation Inhibitors; Quinidine; Sodium Fluoride; Stereoisomerism; Ticlopidine | 2012 |
Pharmacodynamic effect of cilostazol plus standard clopidogrel versus double-dose clopidogrel in patients with type 2 diabetes undergoing percutaneous coronary intervention.
Topics: Cilostazol; Clopidogrel; Diabetes Mellitus, Type 2; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Tetrazoles; Ticlopidine | 2012 |
[CYP2C19 gene polymorphism in patients with myocardial infarction who use clopidogrel].
Topics: Aged; Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Aspirin; Biotransformation; Clopidogrel; Coronary Angiography; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Ticlopidine; Treatment Outcome | 2012 |
[Comparison of three methods of antithrombotic therapy in elderly patients with nonvalvular atrial fibrillation].
Topics: Administration, Oral; Aged; Anticoagulants; Antithrombins; Aspirin; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Clopidogrel; Dabigatran; Drug Monitoring; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Stroke; Survival Rate; Ticlopidine; Treatment Outcome; Warfarin | 2012 |
Complex coronary lesions and rotational atherectomy: one hospital's experience.
Topics: Aged; Angiography; Aspirin; Atherectomy, Coronary; Cardiology; Clopidogrel; Comorbidity; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Radiography, Interventional; Retrospective Studies; Ticlopidine; Treatment Outcome | 2012 |
Dissecting pharmacodynamics to determine the optimal sampling time and measurement for assessing the antiplatelet effect of clopidogrel.
Topics: Adult; Area Under Curve; Clopidogrel; Drug Monitoring; Humans; Linear Models; Male; Middle Aged; Models, Biological; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Ticlopidine; Treatment Outcome; Young Adult | 2012 |
[Removal of epidural catheter under dual antiplatelet therapy following acute coronary syndrome : scenario without special consideration to the current guidelines on epidural regional anesthesia].
Topics: Acute Coronary Syndrome; Analgesia, Epidural; Aspirin; Catheterization; Clopidogrel; Digestive System Surgical Procedures; Drug Interactions; Hemorrhage; Humans; Male; Middle Aged; Pain, Postoperative; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Risk; Thiophenes; Ticlopidine | 2012 |
Clopidogrel versus aspirin in patients with atherothrombosis: a CAPRIE-based cost-effectiveness model for Greece.
Topics: Aspirin; Atherosclerosis; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Greece; Humans; Models, Economic; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Secondary Prevention; Thrombosis; Ticlopidine; Treatment Outcome | 2012 |
Traumatic brain injury in the elderly: considerations in a series of 103 patients older than 70.
Topics: Accidental Falls; Age Distribution; Aged; Aged, 80 and over; Brain Injuries; Clopidogrel; Female; Glasgow Coma Scale; Hematoma, Subdural; Humans; Male; Morbidity; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Subarachnoid Hemorrhage, Traumatic; Ticlopidine; Treatment Outcome | 2012 |
One-year follow-up healthcare costs of patients hospitalized for transient ischemic attack or ischemic stroke and discharged with aspirin plus extended-release dipyridamole or clopidogrel.
Topics: Adolescent; Adult; Age Factors; Aged; Aspirin; Clopidogrel; Delayed-Action Preparations; Drug Therapy, Combination; Female; Health Care Costs; Health Expenditures; Health Services; Humans; Insurance Claim Review; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Sex Factors; Stroke; Ticlopidine; Young Adult | 2012 |
Platelet aggregation at discharge: a useful tool in acute coronary syndromes?
Topics: Acute Coronary Syndrome; Clopidogrel; Female; Humans; Longitudinal Studies; Male; Middle Aged; Patient Discharge; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine | 2012 |
When coronary angiography is not enough to detect spontaneous left main coronary artery dissection.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aortic Dissection; Aspirin; Clopidogrel; Coronary Aneurysm; Coronary Angiography; Drug Therapy, Combination; Drug-Eluting Stents; Electrocardiography; Everolimus; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Metoprolol; Platelet Aggregation Inhibitors; Risk Factors; Sirolimus; Smoking; Ticlopidine; Treatment Outcome | 2012 |
Simultaneous thromboses of two coronary arteries in a heavy smoker woman: a singular case of acute myocardial infarction.
Topics: Abciximab; Aged; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunoglobulin Fab Fragments; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Smoking; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Aspirin- and clopidogrel-associated bleeding complications: data mining of the public version of the FDA adverse event reporting system, AERS.
Topics: Adverse Drug Reaction Reporting Systems; Aspirin; Clopidogrel; Data Mining; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine; United States; United States Food and Drug Administration; Warfarin | 2012 |
Obesity and intracranial in-stent thrombosis.
Topics: Abciximab; Angioplasty, Balloon; Antibodies, Monoclonal; Aspirin; Body Mass Index; Brain Ischemia; Cerebral Angiography; Clopidogrel; Endovascular Procedures; Humans; Immunoglobulin Fab Fragments; Intracranial Thrombosis; Male; Middle Aged; Obesity, Morbid; Platelet Aggregation Inhibitors; Risk; Stents; Stroke; Ticlopidine | 2013 |
[Three case reports of the use of herbal combinations resulted in stent thrombosis: herbal combinations; friend or foe?].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Avena; Chest Pain; Clopidogrel; Coronary Angiography; Coronary Vessels; Female; Humans; Male; Middle Aged; Panax; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Tribulus | 2012 |
Effects of 600 mg versus 300 mg loading dose of clopidogrel in Asian patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: long-term follow-up study.
Topics: Aged; Clopidogrel; Drug Administration Schedule; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Ticlopidine; Treatment Outcome | 2012 |
Bleeding after initiation of multiple antithrombotic drugs, including triple therapy, in atrial fibrillation patients following myocardial infarction and coronary intervention: a nationwide cohort study.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Aspirin; Atrial Fibrillation; Clopidogrel; Cohort Studies; Comorbidity; Denmark; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Registries; Risk Factors; Stroke; Ticlopidine; Vitamin K | 2012 |
Atopaxar: a review of its mechanism of action and role in patients with coronary artery disease.
Topics: Acute Coronary Syndrome; Animals; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Humans; Imines; Platelet Activation; Platelet Aggregation Inhibitors; Pyridines; Receptors, Thrombin; Ticlopidine | 2012 |
[Prevalence of CYP2C19 polymorphisms involved in clopidogrel metabolism in Fujian Han population].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; China; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Ticlopidine; Young Adult | 2012 |
[Impact of proton pump inhibitor omeprazole on the antiplatelet effect of clopidogrel in individuals with various CYP2C19*2 genotypes].
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2012 |
Left ventricular assist device thrombosis due to clopidogrel resistance.
Topics: Clopidogrel; Drug Resistance; Heart-Assist Devices; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Failure | 2012 |
Impact of proton pump inhibitors or famotidine on the antiplatelet actions during dual-antiplatelet therapy in Japanese patients.
Topics: Aged; Asian People; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Interactions; Famotidine; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Ticlopidine | 2013 |
Impaired bioavailability and antiplatelet effect of high-dose clopidogrel in patients after cardiopulmonary resuscitation (CPR).
Topics: Administration, Oral; Aged; Aged, 80 and over; Biological Availability; Blood Platelets; Cardiopulmonary Resuscitation; Chromatography, High Pressure Liquid; Clopidogrel; Critical Illness; Female; Humans; Hypothermia, Induced; Intubation, Gastrointestinal; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Respiration, Artificial; Stents; Tablets; Thrombelastography; Ticlopidine | 2013 |
Antiplatelet drugs in elective ENT surgery.
Topics: Aspirin; Blood Loss, Surgical; Clinical Protocols; Clopidogrel; Data Collection; Elective Surgical Procedures; Health Knowledge, Attitudes, Practice; Humans; Otolaryngology; Otorhinolaryngologic Surgical Procedures; Perioperative Care; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2012 |
Cerebral infarction following a carotid Doppler ultrasound: a chance association?
Topics: Biomarkers; Cerebral Infarction; Clopidogrel; Coronary Angiography; Echocardiography; Female; Humans; Imaging, Three-Dimensional; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Tomography, X-Ray Computed; Troponin T; Ultrasonography, Doppler, Transcranial; Warfarin | 2012 |
The platelet P2Y(12) receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [(3)H]PSB-0413.
Topics: Adenosine Monophosphate; Animals; Binding, Competitive; Blood Platelets; Cell Line, Tumor; Cell Membrane; Clopidogrel; Data Interpretation, Statistical; Humans; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2X Receptor Antagonists; Radioligand Assay; Radiopharmaceuticals; Receptors, Purinergic P2Y12; Sulfhydryl Reagents; Thionucleosides; Ticlopidine | 2013 |
[Case report: patient with central nervous system side effects due to lafutidine].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetamides; Anti-Ulcer Agents; Central Nervous System Diseases; Clopidogrel; Histamine H2 Antagonists; Humans; Middle Aged; Piperidines; Pyridines; Rabeprazole; Stomach Ulcer; Ticlopidine | 2012 |
Combination of cilostazol and clopidogrel attenuates rat critical limb ischemia.
Topics: Animals; Blotting, Western; Cilostazol; Clopidogrel; Drug Therapy, Combination; Extremities; Flow Cytometry; Immunohistochemistry; Ischemia; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Tetrazoles; Ticlopidine | 2012 |
Evaluation of ticagrelor pharmacodynamic interactions with reversibly binding or non-reversibly binding P2Y(12) antagonists in an ex-vivo canine model.
Topics: Adenosine; Adenosine Monophosphate; Animals; Blood Platelets; Clopidogrel; Dogs; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2012 |
High frequency of CYP2C19*2 carriers in PCI-treated patients switched over from clopidogrel to prasugrel based on platelet function monitoring.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Substitution; Heterozygote; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2013 |
Clinical interest of point-of-care pharmacogenomic testing: clopidogrel behind warfarin.
Topics: Aryl Hydrocarbon Hydroxylases; Biomarkers, Pharmacological; Blood Coagulation; Clopidogrel; Cytochrome P-450 CYP2C9; Humans; Mixed Function Oxygenases; Pharmacogenetics; Point-of-Care Systems; Ticlopidine; Vitamin K Epoxide Reductases; Warfarin | 2012 |
Aspirin use and the risk of prostate cancer mortality in men treated with prostatectomy or radiotherapy.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Chemoprevention; Clopidogrel; Enoxaparin; Humans; Male; Middle Aged; Prostatectomy; Prostatic Neoplasms; Risk; Ticlopidine; Warfarin | 2012 |
Early and late outcome associated with bleeding events in the setting of dual antiplatelet therapy following stent placement.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Less may be more: insights on dual antiplatelet therapy duration after drug-eluting stent implantation from the MATRIX registry.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Tacrolimus; Ticlopidine | 2012 |
Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction.
Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cohort Studies; Coronary Thrombosis; Cyclooxygenase 1; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Population Surveillance; Stents; Ticlopidine | 2013 |
Failure of high-dose clopidogrel in recurrent stent thrombosis.
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Drug-Eluting Stents; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine; Treatment Failure | 2012 |
Clinical efficacy and safety of biodegradable polymer-based sirolimus-eluting stents in patients with diabetes mellitus insight from the 4-year results of the create study.
Topics: Absorbable Implants; Aged; Aspirin; Cardiovascular Agents; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymers; Prospective Studies; Prosthesis Design; Registries; Risk Assessment; Risk Factors; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Mortality in the TRACER and ATLAS ACS 2 trials: two more reasons to audit vital records in PLATO.
Topics: Acute Coronary Syndrome; Clinical Trials as Topic; Clopidogrel; Humans; Medical Audit; Platelet Aggregation Inhibitors; Risk; Survival Rate; Ticlopidine; Treatment Outcome | 2012 |
Association of clopidogrel treatment with risk of mortality and cardiovascular events following myocardial infarction in patients with and without diabetes.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Data Collection; Denmark; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Mortality; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Registries; Risk; Ticlopidine | 2012 |
Antiplatelet therapy following myocardial infarction in patients with diabetes.
Topics: Cardiovascular Diseases; Clopidogrel; Diabetes Mellitus; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Gastrointestinal events with clopidogrel: a nationwide population-based cohort study.
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Denmark; Dose-Response Relationship, Drug; Drug Utilization; Female; Gastritis; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Peptic Ulcer; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine | 2013 |
Platelets in vascular disease.
Topics: Aspirin; Atherosclerosis; Blood Platelets; Clopidogrel; Hemostasis; Humans; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Vascular Diseases | 2013 |
Warfarin and clopidogrel interruption before and after colonoscopic polypectomy: results of a survey from a US national audience.
Topics: Aged; Anticoagulants; Clopidogrel; Colonic Polyps; Colonoscopy; Contraindications; Drug Administration Schedule; Guideline Adherence; Humans; Male; Practice Guidelines as Topic; Surveys and Questionnaires; Ticlopidine; Warfarin | 2012 |
Genetic polymorphisms of CYP2C19 influences the response to clopidogrel in ischemic heart disease patients in the South Indian Tamilian population.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Chi-Square Distribution; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; India; Linear Models; Male; Middle Aged; Multivariate Analysis; Myocardial Ischemia; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Precision Medicine; Risk Factors; Ticlopidine; Treatment Outcome | 2013 |
Incidence of cerebral ischemic events after discontinuation of clopidogrel in patients with intracranial aneurysms treated with stent-assisted techniques.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Stroke; Subarachnoid Hemorrhage; Ticlopidine | 2012 |
Side effects of proton pump inhibitors.
Topics: Clopidogrel; Diarrhea; Drug Interactions; Gastroesophageal Reflux; Hip Fractures; Humans; Platelet Aggregation Inhibitors; Pneumonia; Proton Pump Inhibitors; Recurrence; Stomach Ulcer; Ticlopidine | 2012 |
Femoral pseudoaneurysm with a communicating arteriovenous fistula: a complication after percutaneous coronary intervention.
Topics: Aneurysm, False; Angioplasty, Balloon, Coronary; Arteriovenous Fistula; Aspirin; Clopidogrel; Comorbidity; Coronary Artery Disease; Drug Therapy, Combination; Femoral Artery; Fibrinolytic Agents; Humans; Male; Middle Aged; Ticlopidine; Treatment Outcome | 2012 |
Association of CYP2C19 genotype with periprocedural myocardial infarction after uneventful stent implantation in Chinese patients receiving clopidogrel pretreatment.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Aryl Hydrocarbon Hydroxylases; Asian People; Blood Platelets; Chi-Square Distribution; China; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Stents; Thrombelastography; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
The cost effectiveness of genetic testing for CYP2C19 variants to guide thienopyridine treatment in patients with acute coronary syndromes: a New Zealand evaluation.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Decision Trees; Diagnosis-Related Groups; Drugs, Generic; Female; Genetic Testing; Hospital Costs; Hospitalization; Humans; Male; Middle Aged; Monte Carlo Method; Native Hawaiian or Other Pacific Islander; New Zealand; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Quality-Adjusted Life Years; Thiophenes; Ticlopidine | 2012 |
Besides CYP2C19, PON1 genetic variant influences post-clopidogrel platelet reactivity in Chinese patients.
Topics: Acute Coronary Syndrome; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Asian People; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Humans; Male; Middle Aged; Prospective Studies; Ticlopidine | 2013 |
Biological efficacy and clinical safety of a second 600 mg loading dose of clopidogrel in elderly patients with high on-treatment platelet reactivity: a pilot study.
Topics: Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Pilot Projects; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2013 |
Clopidogrel delays gastric ulcer healing in rats.
Topics: Animals; Cell Line; Cell Proliferation; Clopidogrel; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Gastric Mucosa; Gene Expression Regulation; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stomach Ulcer; Ticlopidine; Time Factors; Wound Healing | 2012 |
Comparison between initial and chronic response to clopidogrel therapy after coronary stenting for acute coronary syndrome and influence on clinical outcomes.
Topics: Acute Coronary Syndrome; Aged; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Incidence; Male; Microfilament Proteins; Middle Aged; Percutaneous Coronary Intervention; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Period; Prospective Studies; Stents; Ticlopidine; Treatment Outcome | 2012 |
Prescribing patterns of antiplatelet agents are highly variable after lower extremity endovascular procedures.
Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Administration Schedule; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization; Drug Utilization Review; Endovascular Procedures; Guideline Adherence; Health Care Surveys; Humans; Lower Extremity; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Stents; Surveys and Questionnaires; Ticlopidine; Time Factors; Warfarin | 2013 |
Prevalence of ex vivo high on-treatment platelet reactivity on antiplatelet therapy after transient ischemic attack or ischemic stroke on the PFA-100(®) and VerifyNow(®).
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Aspirin, Dipyridamole Drug Combination; Blood Platelets; Brain Ischemia; Clopidogrel; Cross-Sectional Studies; Dipyridamole; Drug Combinations; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Ticlopidine | 2013 |
Intracoronary GP IIb/IIIa inhibitors: could eptifibatide be the new kid on the block?
Topics: Clopidogrel; Eptifibatide; Female; Humans; Male; Myocardial Infarction; Myocardial Reperfusion; Peptides; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2012 |
Clinical significance of the clopidogrel-proton pump inhibitor interaction after peripheral endovascular intervention for claudication.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon; Chi-Square Distribution; Clopidogrel; Comorbidity; Constriction, Pathologic; Drug Interactions; Female; Femoral Artery; Humans; Intermittent Claudication; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Vascular Patency | 2012 |
Effects of CYP2C19 variant alleles on postclopidogrel platelet reactivity and clinical outcomes in an actual clinical setting in China.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Blood Platelets; China; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2012 |
Effects of low-dose acetylsalicylic acid and atherosclerotic vascular diseases on the outcome in patients with severe sepsis or septic shock.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Blood Coagulation; Clopidogrel; Female; Hospital Mortality; Humans; Intensive Care Units; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Sepsis; Shock, Septic; Ticlopidine; Treatment Outcome | 2013 |
Transfusion outcomes in patients undergoing coronary artery bypass grafting treated with prasugrel or clopidogrel: TRITON-TIMI 38 retrospective data analysis.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass; Humans; Piperazines; Platelet Aggregation Inhibitors; Platelet Transfusion; Prasugrel Hydrochloride; Retrospective Studies; Risk Factors; Thiophenes; Ticlopidine | 2013 |
[Surgery shortly after stent implantation?].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Contraindications; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Elective Surgical Procedures; Hernia, Inguinal; Herniorrhaphy; Humans; Male; Postoperative Hemorrhage; Risk Assessment; Ticlopidine | 2012 |
The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.
Topics: Adenosine Diphosphate; Animals; Arthritis, Experimental; Bone Neoplasms; Bone Remodeling; Bone Resorption; Carcinoma; Cell Adhesion; Cells, Cultured; Clopidogrel; Enzyme Activation; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoclasts; Osteoporosis; Ovariectomy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2Y Receptor Antagonists; rap1 GTP-Binding Proteins; Receptors, Purinergic P2Y12; Specific Pathogen-Free Organisms; Ticlopidine | 2012 |
[General antithrombotic therapy practice facing fundamental change].
Topics: Aspirin; Cause of Death; Clopidogrel; Coronary Restenosis; Drug Therapy, Combination; Fibrinolytic Agents; Follow-Up Studies; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stents; Survival Rate; Ticlopidine | 2012 |
Secondary stroke prevention: misguided by guidelines?
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Retrospective Studies; Secondary Prevention; Stroke; Ticlopidine | 2012 |
Dual antiplatelet therapy after drug-eluting stent implantation: is it time to slacken the reins?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Stenosis; Drug-Eluting Stents; Female; Humans; Male; Medication Adherence; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Sirolimus; Ticlopidine; Withholding Treatment | 2012 |
Double antiplatelet therapy after drug-eluting stent implantation: risk associated with discontinuation within the first year.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Medication Adherence; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Risk Factors; Spain; Survival Rate; Ticlopidine; Time Factors | 2012 |
Proton-pump inhibitors could be innocent when used concomitantly with clopidogrel.
Topics: Acute Coronary Syndrome; Anti-Ulcer Agents; Aspirin; Blood Platelets; Clopidogrel; Famotidine; Female; Humans; Male; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Effect of exposure to evidence-based pharmacotherapy on outcomes after acute myocardial infarction in older adults.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Chemoprevention; Clopidogrel; Evidence-Based Practice; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Secondary Prevention; Ticlopidine; Treatment Outcome | 2012 |
Influence of ischemia before vein grafting on early hyperplasia of the graft and the dynamic changes of the intima after grafting.
Topics: Animals; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Cell Proliferation; Clopidogrel; Endothelial Cells; Histocytochemistry; Hyperplasia; Ischemia; Ki-67 Antigen; Microscopy, Electron, Scanning; Platelet Aggregation Inhibitors; Rabbits; Ticlopidine; Tunica Intima | 2012 |
Successful resection of complicated bleeding arteriovenous malformation of the jejunum in patients starting dual-antiplatelet therapy just after implanting a drug-eluting coronary stent.
Topics: Arteriovenous Malformations; Aspirin; Clopidogrel; Drug-Eluting Stents; Gastrointestinal Hemorrhage; Humans; Jejunum; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine | 2012 |
Impact of clopidogrel resistance on ST-segment resolution and no-reflow in acute myocardial infarction with ST-elevation patients treated with a primary percutaneous coronary intervention.
Topics: Clopidogrel; Coronary Angiography; Coronary Circulation; Drug Resistance; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; No-Reflow Phenomenon; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recovery of Function; Ticlopidine; Treatment Outcome | 2012 |
Three years ago I received a drug-coated stent and was put on aspirin and Plavix. My cardiologist recently retired, and my new cardiologist told me to stop taking Plavix. It scares me to death. I read the story you released in February about the danger
Topics: Clopidogrel; Contraindications; Coronary Artery Disease; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Withholding Treatment | 2011 |
I am a 37-year-old woman and was diagnosed with coronary artery spasms two years ago. I am taking Plavix, verapamil and Imdur for my condition. What other things can I do to help my heart?
Topics: Adult; Clopidogrel; Coronary Vasospasm; Coronary Vessels; Female; Health Behavior; Health Knowledge, Attitudes, Practice; Humans; Isosorbide Dinitrate; Ticlopidine; Vasodilator Agents; Verapamil | 2011 |
Pharmacokinetics of clopidogrel in healthy Chinese volunteers.
Topics: Adolescent; Adult; Area Under Curve; Asian People; Chromatography, High Pressure Liquid; Clopidogrel; Half-Life; Humans; Indicators and Reagents; Male; Platelet Aggregation Inhibitors; Population; Tandem Mass Spectrometry; Ticlopidine; Young Adult | 2012 |
CYP2C19 681G > A polymorphism and pharmacokinetics of clopidogrel in Chinese healthy volunteers.
Topics: Adult; Alleles; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Chromatography, High Pressure Liquid; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Female; Genotype; Humans; Male; Microarray Analysis; Mutation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Tandem Mass Spectrometry; Ticlopidine; Young Adult | 2012 |
Angiotensin receptor blockers worsen renal function and dyspnea on ticagrelor: a potential ticagrelor-angiotensin receptor blocker interaction?
Topics: Adenosine; Angiotensin II Type 1 Receptor Blockers; Clopidogrel; Drug Interactions; Dyspnea; Glomerular Filtration Rate; Hemorrhage; Humans; Kidney; Kidney Diseases; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2012 |
Reversible shortness of breath caused by the antiplatelet agent, clopidogrel.
Topics: Aspirin; Cilostazol; Clopidogrel; Dyspnea; Embolization, Therapeutic; Endovascular Procedures; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Tetrazoles; Ticlopidine | 2013 |
Clinical-scientific notes.
Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2012 |
Understand the power of Plavix. This antiplatelet drug prevents in-stent clots in women as well as men.
Topics: Angioplasty, Balloon; Clopidogrel; Coronary Thrombosis; Drug Administration Schedule; Drug-Eluting Stents; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; Women's Health | 2010 |
The impact of reducing cardiovascular medication copayments on health spending and resource utilization.
Topics: Aged; Cardiology; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Cost Sharing; Drug Therapy; Evidence-Based Medicine; Female; Health Care Costs; Health Care Reform; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insurance, Health; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Ticlopidine; Treatment Outcome | 2012 |
Residual platelet activation through protease-activated receptors (PAR)-1 and -4 in patients on P2Y12 inhibitors.
Topics: Adult; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Oligopeptides; Peptide Fragments; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptor, PAR-1; Receptors, Purinergic P2Y12; Receptors, Thrombin; Thiophenes; Ticlopidine | 2013 |
Treatment of blood blister-like aneurysms of the internal carotid artery with stent-assisted coil embolization.
Topics: Aspirin; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Recurrence; Retrospective Studies; Stents; Subarachnoid Hemorrhage; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2013 |
Clopidogrel and cardiac surgery: enemy or friend?
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Coronary Artery Bypass, Off-Pump; Coronary Occlusion; Female; Humans; Male; Platelet Aggregation; Ticlopidine | 2012 |
Collagen-induced thrombosis in murine arteries and veins.
Topics: Animals; Arterial Occlusive Diseases; Blood Coagulation; Blood Platelets; Carotid Arteries; Clopidogrel; Collagen; Disease Models, Animal; Epigastric Arteries; Femoral Vein; Fibrin; Mice; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Time Factors; Venous Thrombosis | 2013 |
Longitudinal assessment of thrombin generation potential in response to alteration of antiplatelet therapy after TIA or ischaemic stroke.
Topics: Adult; Aged; Aspirin; Clopidogrel; Dipyridamole; Female; Humans; Ischemic Attack, Transient; Longitudinal Studies; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Statistics, Nonparametric; Stroke; Thrombin; Ticlopidine | 2013 |
Limitations of using cardiac catheterization rates to assess the quality of care for patients with non-ST-segment elevation myocardial infarction.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Aged, 80 and over; Aspirin; Cardiac Catheterization; Clopidogrel; Comorbidity; Contraindications; Critical Pathways; Female; Guideline Adherence; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Infarction; Registries; Ticlopidine; United States | 2012 |
Antithrombotic therapy for atrial fibrillation and coronary artery disease in older patients.
Topics: Age Factors; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Diabetes Complications; Female; Fibrinolytic Agents; Heart Failure; Humans; Hypertension; Male; Risk Assessment; Stroke; Ticlopidine; Treatment Outcome; Warfarin | 2012 |
Dual antiplatelet agent-induced spontaneous liver hematoma.
Topics: Aged; Aspirin; Chemical and Drug Induced Liver Injury; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Hematoma; Humans; Male; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2012 |
Comparison of outcomes in patients with head trauma, taking preinjury antithrombotic agents.
Topics: Aged; Aged, 80 and over; Aspirin; Australia; Clopidogrel; Craniocerebral Trauma; Drug Therapy, Combination; Emergency Service, Hospital; Female; Fibrinolytic Agents; Glasgow Coma Scale; Hospital Mortality; Humans; Intensive Care Units; Male; Outcome Assessment, Health Care; Prospective Studies; Ticlopidine; Warfarin | 2013 |
Predictors of early, late, and very late stent thrombosis after primary percutaneous coronary intervention with bare-metal and drug-eluting stents for ST-segment elevation myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Confidence Intervals; Coronary Restenosis; Coronary Thrombosis; Drug-Eluting Stents; Female; Health Status Indicators; Humans; Kaplan-Meier Estimate; Male; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Risk Factors; Severity of Illness Index; Ticlopidine; Time Factors; United States | 2012 |
Effects of rivaroxaban, acetylsalicylic acid and clopidogrel as monotherapy and in combination in a porcine model of stent thrombosis.
Topics: Animals; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Morpholines; Platelet Aggregation; Rivaroxaban; Stents; Swine; Swine, Miniature; Thiophenes; Thrombosis; Ticlopidine | 2012 |
Reduction in platelet reactivity with prasugrel 5 mg in low-body-weight patients is noninferior to prasugrel 10 mg in higher-body-weight patients: results from the FEATHER trial.
Topics: Adolescent; Adult; Aged; Blood Platelets; Body Weight; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Single-Blind Method; Thiophenes; Ticlopidine; Young Adult | 2012 |
Platelet reactivity in diabetic patients undergoing coronary stenting for acute coronary syndrome treated with clopidogrel loading dose followed by prasugrel maintenance therapy.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Triple antithrombotic therapy following an acute coronary syndrome: prevalence, outcomes and prognostic utility of the HAS-BLED score.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Aspirin; Chi-Square Distribution; Clopidogrel; Comorbidity; Decision Support Techniques; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Sweden; Ticlopidine; Treatment Outcome; Warfarin | 2012 |
Antidepressant use, serotonin transporter affinity, and reinfarction among patients receiving clopidogrel: a population-based study.
Topics: Acute Disease; Aged; Aged, 80 and over; Antidepressive Agents; Case-Control Studies; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Serotonin Plasma Membrane Transport Proteins; Ticlopidine | 2012 |
Evaluating the impact of public health notification: Duke clopidogrel experience.
Topics: Access to Information; Aged; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Information Services; Drug-Eluting Stents; Evidence-Based Medicine; Female; Humans; Logistic Models; Male; Metals; Middle Aged; North Carolina; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prosthesis Design; Public Health Informatics; Registries; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Prevention of stent thrombosis with reduced dose of prasugrel in two patients undergoing treatment of cerebral aneurysms with pipeline embolisation devices.
Topics: Blood Platelets; Clopidogrel; Embolization, Therapeutic; Female; Hemorrhage; Humans; Intracranial Aneurysm; Intracranial Thrombosis; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Thiophenes; Ticlopidine; Treatment Outcome | 2012 |
Monitoring residual platelet activity among patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Ticlopidine | 2014 |
Oral anticoagulation and the risk of vitreous hemorrhage and retinal tears in eyes with acute posterior vitreous detachment.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Retinal Detachment; Retinal Perforations; Retrospective Studies; Risk Assessment; Ticlopidine; Vitreous Detachment; Vitreous Hemorrhage; Warfarin | 2013 |
The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
Topics: Carboxylic Ester Hydrolases; Clopidogrel; Coronary Artery Disease; DNA; Female; Genotype; Heterozygote; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Prognosis; Ticlopidine | 2013 |
Effects of pre-hospital clopidogrel administration on early and late residual platelet reactivity in ST-segment elevation myocardial infarction patients undergoing primary intervention.
Topics: Aged; Belgium; Blood Platelets; Clopidogrel; Coronary Thrombosis; Drug Administration Schedule; Emergency Medical Services; Female; Humans; Ischemic Attack, Transient; Italy; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Recurrence; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Clopidogrel variability: role of plasma protein binding alterations.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Blood Proteins; Cell Adhesion Molecules; Chromatography, Liquid; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Female; Genotyping Techniques; Humans; Mass Spectrometry; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Protein Binding; Statistics as Topic; Ticlopidine | 2013 |
[Platelet inhibition in clinical practice].
Topics: Aged; Angioplasty, Balloon, Coronary; Arterial Occlusive Diseases; Aspirin; Cerebral Infarction; Clopidogrel; Coronary Artery Bypass; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Patient Compliance; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Transfusion; Risk Factors; Thrombosis; Ticlopidine | 2012 |
Measured drug effect and cardiovascular outcomes in patients receiving platelet P2Y12 receptor antagonists: clarifying the time and place for intensive inhibition.
Topics: Acute Coronary Syndrome; Clopidogrel; Female; Humans; Male; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2012 |
[Antiaggregation therapy after percutaneous coronary intervention in a patient with thrombocytopenia: case report].
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Stents; Thrombocytopenia; Ticlopidine | 2011 |
Statements of the Malaysian Society of Gastroenterology & Hepatology and the National Heart Association of Malaysia task force 2012 working party on the use of antiplatelet therapy and proton pump inhibitors in the prevention of gastrointestinal bleeding.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Malaysia; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2013 |
Aspirin and clopidogrel alter core temperature and skin blood flow during heat stress.
Topics: Aged; Aspirin; Body Temperature Regulation; Clopidogrel; Cross-Over Studies; Double-Blind Method; Exercise Test; Female; Heat Stress Disorders; Humans; Laser-Doppler Flowmetry; Male; Middle Aged; Pennsylvania; Platelet Aggregation Inhibitors; Regional Blood Flow; Skin; Thermography; Ticlopidine | 2013 |
Lowering homocysteine levels may prevent cardiovascular impairments? Possible therapeutic behaviors.
Topics: Acetylcysteine; Aspirin; Blood Vessels; Cardiovascular Diseases; Clopidogrel; Diuretics; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Platelet Aggregation Inhibitors; S-Adenosylmethionine; Ticlopidine; Vitamin B 12; Vitamin B 6 | 2012 |
Postmenopausal women have an increased maximal platelet reactivity compared to men despite dual antiplatelet therapy.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Postmenopause; Prospective Studies; Sex Factors; Ticlopidine | 2012 |
Short-term effects of aspirin and clopidogrel on mean platelet volume among patients with acute coronary syndromes. A single-center prospective study.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Platelets; Cell Size; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Ticlopidine; Treatment Outcome | 2012 |
Genetic testing in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a cost-effectiveness analysis.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Cerebrovascular Disorders; Clopidogrel; Computer Simulation; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Decision Support Techniques; Disease-Free Survival; Drug Costs; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Health Care Costs; Hemorrhage; Humans; Insurance, Health, Reimbursement; Kaplan-Meier Estimate; Markov Chains; Medicare; Models, Economic; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Predictive Value of Tests; Quality-Adjusted Life Years; Risk Assessment; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; United States | 2013 |
Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Benzoates; Chromatography, High Pressure Liquid; Clopidogrel; Cyclosporine; Dogs; Drug Interactions; Female; Platelet Aggregation Inhibitors; Quercetin; Rats; Rats, Sprague-Dawley; Species Specificity; Telmisartan; Ticlopidine | 2012 |
Discontinuation of long-term clopidogrel therapy is associated with death and myocardial infarction after saphenous vein graft percutaneous coronary intervention.
Topics: Aged; California; Cause of Death; Clopidogrel; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Refusal to Treat; Retrospective Studies; Risk Factors; Saphenous Vein; Survival Rate; Ticlopidine | 2012 |
Near patient anti-platelet response testing over time and gene analysis in patients admitted with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Expression Regulation; Gene Frequency; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
[Current clinical practice among German Internists regarding the prophylaxis of gastroduodenal ulcers associated with NSAIDs, aspirin and Helicobacter pylori].
Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Clopidogrel; Coronary Disease; Cyclooxygenase 2 Inhibitors; Drug Substitution; Female; Germany; Health Surveys; Helicobacter Infections; Helicobacter pylori; Humans; Internal Medicine; Long-Term Care; Male; Middle Aged; Peptic Ulcer; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proton Pump Inhibitors; Surveys and Questionnaires; Ticlopidine | 2012 |
Reversal of thienopyridine-induced platelet dysfunction following desmopressin administration.
Topics: Animals; Antidiuretic Agents; Bleeding Time; Clopidogrel; Deamino Arginine Vasopressin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Overdose; Hemostatics; Injections, Intravenous; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Purinergic P2Y Receptor Antagonists; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Ticlopidine | 2013 |
Treatment of a pediatric recurrent fusiform middle cerebral artery (MCA) aneurysm with a flow diverter.
Topics: Adolescent; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Male; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine | 2012 |
Management and outcomes of patients on preoperative plavix (clopidogrel) undergoing general thoracic surgery.
Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Blood Transfusion; Cardiovascular Diseases; Clopidogrel; Drug Administration Schedule; Drug Substitution; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Propensity Score; Reoperation; Retrospective Studies; Risk Factors; Thoracic Surgical Procedures; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
[Expert answer. Coronary artery patients with atrial fibrillation on anticoagulation treatment may need antithrombotic treatment. What kind is there?].
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Ticlopidine; Warfarin | 2012 |
Current status of clopidogrel pharmacogenomics.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2012 |
A new generation of biodegradable polymer-coated sirolimus-eluting stents for the treatment of coronary artery disease: final 5-year clinical outcomes from the CREATE study.
Topics: Absorbable Implants; Aged; Aspirin; Cardiovascular Agents; China; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Disease-Free Survival; Drug Therapy, Combination; Drug-Eluting Stents; Female; Heart Failure; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymers; Propensity Score; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Registries; Risk Assessment; Risk Factors; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome | 2012 |
Long-term results of plaque excision combined with aggressive pharmacotherapy in high-risk patients with advanced peripheral artery disease (SAVE a LEG registry).
Topics: Adult; Aged; Aged, 80 and over; Amputation, Surgical; Aspirin; Atherectomy; Atorvastatin; Cardiovascular Agents; Clopidogrel; Combined Modality Therapy; Critical Illness; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Intermittent Claudication; Ischemia; Kaplan-Meier Estimate; Limb Salvage; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Pyrroles; Recurrence; Registries; Retrospective Studies; Risk Factors; Severity of Illness Index; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
I'm having a stent put in one of my coronary arteries soon and I wonder how long I will need to be on clopidogrel. Does it depend on the kind of stent?
Topics: Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2010 |
Chest pain in a patient with coronary artery disease taking clopidogrel.
Topics: Chest Pain; Clopidogrel; Coronary Artery Disease; Esophageal Diseases; Esophagoscopy; Hematoma; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Tomography, X-Ray Computed | 2013 |
Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions.
Topics: Adult; Aged; Area Under Curve; Arteries; Aspirin; Automation, Laboratory; Blood Platelets; Capillaries; Case-Control Studies; Clopidogrel; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Microchip Analytical Procedures; Middle Aged; Monocytes; P-Selectin; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Regional Blood Flow; ROC Curve; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Alcohol Drinking; Angina Pectoris; Body Weight; Cholesterol, LDL; Clopidogrel; Comorbidity; Cost of Illness; Depression; Diabetes Complications; Disease Management; Electrocardiography; Exercise; Exercise Test; Glycated Hemoglobin; Health Behavior; Humans; Hypertension; Life Style; Myocardial Infarction; Myocardial Ischemia; Myocardial Revascularization; Physical Examination; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Quality of Life; Risk Assessment; Risk Factors; Risk Reduction Behavior; Smoking Cessation; Ticlopidine | 2012 |
Trilogy: in search of the lost ring.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clinical Trials as Topic; Clopidogrel; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2013 |
Resistance to clopidogrel: prevalence and associate variables.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2012 |
Safety of endoscopic sphincterotomy in patients under dual antiplatelet therapy.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cholangiopancreatography, Endoscopic Retrograde; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Patient Safety; Platelet Aggregation Inhibitors; Retrospective Studies; Sphincterotomy, Endoscopic; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
I sometimes see medication labels that read "not to be taken with blood thinner." Is clopidogrel, which I have taken for several years a blood thinner and what other drugs are especially dangerous with clopidogrel?
Topics: Anticoagulants; Clopidogrel; Drug Interactions; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2010 |
Pharmacokinetics of vicagrel, a promising analog of clopidogrel, in rats and beagle dogs.
Topics: Animals; Clopidogrel; Dogs; Female; Male; Phenylacetates; Rats; Rats, Sprague-Dawley; Thiophenes; Ticlopidine | 2013 |
Clopidogrel resistance is associated with thromboembolic complications in patients undergoing neurovascular stenting.
Topics: Aged; Aspirin; Blood Platelets; Cerebral Arteries; Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Endovascular Procedures; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Thromboembolism; Ticlopidine | 2013 |
Pharmaceutical care for patients with acute myocardial infarction in Hungary.
Topics: Acute Disease; Adult; Aged; Aspirin; Clopidogrel; Comorbidity; Diabetes Mellitus; Drug Therapy, Combination; Female; Humans; Hungary; Incidence; Male; Middle Aged; Muscle Hypotonia; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Risk; Secondary Prevention; Ticlopidine; Treatment Outcome; Young Adult | 2013 |
[Proton pump inhibitors and clopidogrel: a hazardous association?].
Topics: Clinical Trials as Topic; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Models, Biological; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2013 |
The effect of Neuroform stent-assisted coil embolization of wide-necked intracranial aneurysms and clinical factors on progressive aneurysm occlusion on angiographic follow-up.
Topics: Adult; Aspirin; Cerebral Angiography; Clopidogrel; Disease Progression; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Male; Middle Aged; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2013 |
Influence of genetic and non-genetic factors on the plasma concentrations of the clopidogrel metabolite (SR26334) among Chinese patients.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Ticlopidine | 2013 |
Effect of routine clopidogrel use on bleeding complications after ultrasound-guided thoracentesis.
Topics: Clopidogrel; Contraindications; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Pleural Effusion; Prospective Studies; Respiratory Distress Syndrome; Thoracic Surgical Procedures; Ticlopidine; Ultrasonography, Interventional | 2012 |
The assessment of risk for gastrointestinal injury with anticoagulant and antiplatelet drugs: the possible beneficial effect of eicosapentaenoic Acid for the risk of gastrointestinal injury.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Eicosapentaenoic Acid; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Protective Agents; Retrospective Studies; Risk Assessment; Ticlopidine; Warfarin | 2013 |
Continued concern about parent vessel steno-occlusive progression with Onyx HD-500 and the utility of quantitative magnetic resonance imaging in serial assessment.
Topics: Angioplasty; Aspirin; Carotid Artery Diseases; Carotid Stenosis; Clopidogrel; Constriction, Pathologic; Databases, Factual; Disease Progression; Embolization, Therapeutic; Humans; Intracranial Aneurysm; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2013 |
Clopidogrel pretreatment of patients with ST-elevation myocardial infarction does not affect platelet reactivity after subsequent prasugrel-loading: platelet reactivity in an observational study.
Topics: Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2013 |
HPLC-MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples.
Topics: Aged; Chromatography, High Pressure Liquid; Clopidogrel; Drug Stability; Female; Humans; Isomerism; Linear Models; Male; Reproducibility of Results; Sulfhydryl Compounds; Tandem Mass Spectrometry; Ticlopidine | 2012 |
Delayed eosinophilic gastroenteritis, a possible side effect of clopidogrel?
Topics: Aged; Clopidogrel; Enteritis; Eosinophilia; Female; Gastritis; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation.
Topics: Apoptosis; Blotting, Western; Cell Line; Cell Proliferation; Clopidogrel; Dose-Response Relationship, Drug; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Gastric Mucosa; Gene Expression Regulation; Humans; JNK Mitogen-Activated Protein Kinases; Microscopy, Electron, Transmission; Occludin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation Inhibitors; Signal Transduction; Ticlopidine; Tight Junctions; Zonula Occludens-1 Protein | 2013 |
Deliverability of integrity coronary stents in severely tortuous coronary arteries: a preliminary experience.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Stenosis; Coronary Vessels; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2012 |
Dual antiplatelet therapy in peripheral arterial disease and after peripheral percutaneous revascularization.
Topics: Aspirin; Clopidogrel; Endovascular Procedures; Hemorrhage; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Stents; Stroke; Ticlopidine; Treatment Outcome | 2012 |
Carcinophobia in clinical research.
Topics: Angiotensin Receptor Antagonists; Animals; Biomedical Research; Causality; Clopidogrel; Cyclooxygenase 2 Inhibitors; Humans; Incidence; Insulin Glargine; Insulin, Long-Acting; Neoplasms; Rosiglitazone; Thiazolidinediones; Ticlopidine | 2012 |
Prevention of stent thrombosis with reduced dose of prasugrel in two patients undergoing treatment of cerebral aneurysms with pipeline embolisation devices.
Topics: Carotid Artery, Internal, Dissection; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Current antiplatelet therapy for Japanese patients with ST elevation acute myocardial infarction: J-AMI registry.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Incidence; Japan; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Prospective Studies; Registries; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2013 |
Platelet P2Y₁₂ blockers confer direct postconditioning-like protection in reperfused rabbit hearts.
Topics: Adenosine Monophosphate; Animals; Cardiotonic Agents; Clopidogrel; Coronary Vessels; Female; Heart; In Vitro Techniques; Ischemic Postconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Platelet Activation; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Purinergic P2Y Receptor Antagonists; Rabbits; Receptors, Purinergic P2Y12; Signal Transduction; Ticlopidine | 2013 |
Hospital case volume and appropriate prescriptions at hospital discharge after acute myocardial infarction: a nationwide assessment.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; France; Hospitals, High-Volume; Hospitals, Low-Volume; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Infarction; Patient Discharge; Prescriptions; Quality Assurance, Health Care; Quality Indicators, Health Care; Retrospective Studies; Ticlopidine | 2013 |
Differential prognostic impact of high on-treatment platelet reactivity among patients with acute coronary syndromes versus stable coronary artery disease undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Artery Disease; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Therapeutic momentum: a concept opposite to therapeutic inertia.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Cross-Sectional Studies; Humans; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Sri Lanka; Ticlopidine; Unnecessary Procedures; Withholding Treatment | 2013 |
"Why did my CPAP beat me up?" Bilateral periorbital ecchymosis associated with continuous positive airway pressure therapy.
Topics: Aspirin; Clopidogrel; Continuous Positive Airway Pressure; Dietary Supplements; Ecchymosis; Fish Oils; Humans; Male; Middle Aged; Orbital Diseases; Platelet Aggregation Inhibitors; Sleep Apnea, Obstructive; Ticlopidine; Vitamin E | 2012 |
Bioequivalence in the real world is a complex challenge: the case of clopidogrel.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation Inhibitors; Therapeutic Equivalency; Ticlopidine | 2013 |
Use of medications for secondary prevention after coronary bypass surgery compared with percutaneous coronary intervention.
Topics: Adrenergic beta-Antagonists; Aged; Angioplasty, Balloon, Coronary; Chemoprevention; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Medication Adherence; Middle Aged; Secondary Prevention; Ticlopidine | 2013 |
Evaluation of the pharmacokinetics and pharmacodynamics of ticagrelor co-administered with aspirin in healthy volunteers.
Topics: Adenosine; Adenosine Diphosphate; Adult; Aspirin; Bleeding Time; Clopidogrel; Collagen; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Young Adult | 2013 |
Assessment of high on-treatment platelet reactivity in patients with ischemic heart disease: concordance between the Multiplate and VerifyNow assays.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Reproducibility of Results; Spain; Ticlopidine; Treatment Outcome | 2013 |
Antiplatelet therapy in ischemic stroke: does one size fit all?
Topics: Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2012 |
Spontaneous spinal epidural haematoma after antiplatelet treatment: a report of two cases.
Topics: Aged; Aspirin; Clopidogrel; Decompression, Surgical; Female; Hematoma, Epidural, Spinal; Humans; Laminectomy; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Spinal Fusion; Ticlopidine | 2012 |
Platelet-function testing in patients undergoing neurovascular procedures: caught between a rock and a hard place.
Topics: Cerebral Hemorrhage; Clopidogrel; Drug Resistance; Endovascular Procedures; Female; Humans; Male; Platelet Aggregation Inhibitors; Stents; Thromboembolism; Ticlopidine | 2013 |
Genetic determinants of clopidogrel responsiveness in Koreans treated with drug-eluting stents.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cohort Studies; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Ticlopidine; Treatment Outcome | 2013 |
Upper gastrointestinal lesions in patients receiving clopidogrel anti-platelet therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Endoscopy, Gastrointestinal; Female; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Peptic Ulcer; Platelet Aggregation Inhibitors; Prospective Studies; Smoking; Ticlopidine | 2012 |
Friend or foe? Discussion about dual platelet inhibition as a salvage procedure from imminent flap failure.
Topics: Aspirin; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Mammaplasty; Middle Aged; No-Reflow Phenomenon; Platelet Aggregation Inhibitors; Postoperative Complications; Salvage Therapy; Surgical Flaps; Ticlopidine | 2013 |
Exploring the reduction in myocardial infarctions in the PLATO trial: which patients benefited on ticagrelor vs. clopidogrel?
Topics: Adenosine; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Safety of reloading prasugrel in addition to clopidogrel loading in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aspirin; Chi-Square Distribution; Clopidogrel; Endpoint Determination; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Statistics, Nonparametric; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation.
Topics: Biotransformation; Carboxylic Ester Hydrolases; Cell Line; Clopidogrel; Humans; Hydrolysis; Liver; Nitrophenols; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2013 |
FT-Raman, FT-IR, UV spectroscopic, NBO and DFT quantum chemical study on the molecular structure, vibrational and electronic transitions of clopidogrel hydrogen sulfate form 1: a comparison to form 2.
Topics: Absorption; Calorimetry, Differential Scanning; Clopidogrel; Electrons; Kinetics; Models, Molecular; Molecular Conformation; Quantum Theory; Solvents; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thermodynamics; Ticlopidine; Vibration | 2013 |
A pilot study of prasugrel followed by post-procedural maintenance with clopidogrel in patients receiving percutaneous coronary intervention.
Topics: Aged; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Pilot Projects; Piperazines; Platelet Aggregation Inhibitors; Postoperative Care; Prasugrel Hydrochloride; Preoperative Care; Retrospective Studies; Thiophenes; Ticlopidine | 2013 |
Triple antiplatelet therapy with cilostazol: hitting the "sweet-spot".
Topics: Aspirin; Blood Platelets; Cilostazol; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Tetrazoles; Ticlopidine | 2013 |
Clopidogrel, a platelet P2Y12 receptor inhibitor, reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Blood Platelets; Blood Pressure Determination; Clopidogrel; Cytokines; Immunoenzyme Techniques; Inflammation; Macrophages, Peritoneal; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Aggregation Inhibitors; Reactive Oxygen Species; Receptors, Purinergic P2Y12; Ticlopidine; Vasculitis; Vasoconstrictor Agents | 2012 |
Decreased plasma IL-35 levels are related to the left ventricular ejection fraction in coronary artery diseases.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Cytokines; Female; Humans; Interleukins; Male; Middle Aged; Statistics, Nonparametric; Stroke Volume; Ticlopidine | 2012 |
[Safety and efficacy of various modalities of antiplatelet prophylaxis of ischemic stroke in elderly patients with non-valvular atrial fibrillation].
Topics: Age Factors; Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Brain Ischemia; Clopidogrel; Dabigatran; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Stroke; Thromboembolism; Ticlopidine; Warfarin | 2012 |
Elevated plasma fibrinogen rather than residual platelet reactivity after clopidogrel pre-treatment is associated with an increased ischemic risk during elective percutaneous coronary intervention.
Topics: Aged; Blood Platelets; C-Reactive Protein; Clopidogrel; Coronary Artery Disease; Creatine Kinase, MB Form; Female; Fibrinogen; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Predictive Value of Tests; Premedication; Prospective Studies; ROC Curve; Sensitivity and Specificity; Ticlopidine; Troponin | 2013 |
Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism.
Topics: Animals; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance; Evidence-Based Medicine; History, 20th Century; History, 21st Century; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Translational Research, Biomedical | 2013 |
[Correlation between antiplatelet resistance and recurrent cardiac ischemic events of patients with acute myocardial infarction].
Topics: Aged; Aspirin; Clopidogrel; Drug Resistance; Electric Impedance; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Recurrence; Ticlopidine | 2012 |
Clopidogrel has no effect on mortality from hip fracture.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Female; Hip Fractures; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Severity of Illness Index; Stroke; Ticlopidine; Time Factors; Treatment Outcome; United Kingdom | 2013 |
A huge coronary artery aneurysm in osteogenesis imperfecta: a case report.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Aneurysm; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypotension; Inferior Wall Myocardial Infarction; Osteogenesis Imperfecta; Platelet Aggregation Inhibitors; Rare Diseases; Ticlopidine; Treatment Outcome; Ultrasonography | 2012 |
Benefit of low-dose aspirin and non-steroidal anti-inflammatory drugs in septic patients.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Female; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intensive Care Units; Length of Stay; Male; Middle Aged; Platelet Aggregation Inhibitors; Sepsis; Ticlopidine | 2013 |
X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: insights into compensatory rearrangements of the binding pocket.
Topics: Amino Acid Substitution; Animals; Aryl Hydrocarbon Hydroxylases; Catalytic Domain; Clopidogrel; Crystallography, X-Ray; Cytochrome P450 Family 2; Humans; Mutation, Missense; Protein Structure, Secondary; Rabbits; Ticlopidine | 2013 |
The concurrent use of antithrombotic therapies and the risk of bleeding in patients with atrial fibrillation.
Topics: Aged; Atrial Fibrillation; Case-Control Studies; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Middle Aged; Regression Analysis; Risk Factors; Thrombosis; Ticlopidine; United Kingdom; Warfarin | 2013 |
Hirudin anticoagulation allows more rapid determination of P2Y₁₂ inhibition by the VerifyNow P2Y12 assay.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Antithrombins; Area Under Curve; Cations; Citrates; Clopidogrel; Coronary Angiography; Female; Hematologic Tests; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Function Tests; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Sodium Citrate; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
High on-treatment platelet reactivity (HPR): what does it mean, and does it matter?
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Substitution; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2013 |
Prasugrel reduces agonists' inducible platelet activation and leukocyte-platelet interaction more efficiently than clopidogrel.
Topics: Aged; Blood Platelets; Cell Communication; Clopidogrel; Female; Humans; Male; Middle Aged; Monocytes; P-Selectin; Peptide Fragments; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2013 |
Human platelet protease-activated receptor-1 responsiveness to thrombin related to P2Y12 inhibition.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Models, Cardiovascular; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptor, PAR-1; Receptors, Purinergic P2Y12; Thrombin; Thromboembolism; Ticlopidine; Translational Research, Biomedical | 2013 |
Amlodipine--not a significant contributor to clopidogrel non-response?
Topics: Amlodipine; Calcium Channel Blockers; Clopidogrel; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Humans; Male; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2013 |
Promise and peril of clinical decision support: translating medical evidence to the individual patient.
Topics: Acute Coronary Syndrome; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2013 |
Safety of ultrasound-guided small-bore chest tube insertion in patients on clopidogrel.
Topics: Aged; Chest Tubes; Clopidogrel; Contraindications; Female; Hematoma; Hemothorax; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Ticlopidine; Treatment Outcome; Ultrasonography, Interventional | 2013 |
Antiplatelet efficacy of prasugrel in patients with high on-clopidogrel treatment platelet reactivity and a history of coronary stenting.
Topics: Aged; Blood Platelets; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Registries; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Leucocytoclastic vasculitis as a late complication of clopidogrel therapy.
Topics: Angina, Stable; Biopsy; Clopidogrel; Female; Follow-Up Studies; Humans; Middle Aged; Purinergic P2Y Receptor Antagonists; Skin; Ticlopidine; Vasculitis, Leukocytoclastic, Cutaneous | 2013 |
Risk factors for upper gastrointestinal bleeding in coronary artery disease patients receiving both aspirin and clopidogrel.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Risk Factors; Ticlopidine; Upper Gastrointestinal Tract | 2013 |
Predictors of long-term high on-treatment platelet reactivity in clopidogrel-treated patients undergoing coronary stenting for acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
The CYP2C19 genotype does not impact the long-term prognosis of patients with coronary artery disease.
Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prodrugs; Prognosis; Ticlopidine | 2013 |
Prasugrel vs clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention: a model-based cost-effectiveness analysis for Germany, Sweden, the Netherlands, and Turkey.
Topics: Acute Coronary Syndrome; Age Factors; Clopidogrel; Comorbidity; Cost-Benefit Analysis; Europe; Humans; Markov Chains; Models, Economic; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Thiophenes; Ticlopidine; Turkey | 2013 |
Effect of CYP2C19*2 and *17 genetic variants on platelet response to clopidogrel and prasugrel maintenance dose and relation to bleeding complications.
Topics: Acute Coronary Syndrome; Alleles; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Genotype; Hemorrhage; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Piperazines; Polymerase Chain Reaction; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Obesity is associated with poor response to clopidogrel and an increased susceptibility to protease activated receptor-1 mediated platelet activation.
Topics: Adenosine Diphosphate; Aged; Angioplasty; Blood Platelets; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Obesity; P-Selectin; Phosphoproteins; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptor, PAR-1; Stents; Thrombosis; Ticlopidine; Translational Research, Biomedical | 2013 |
Chronic kidney disease--is it a true risk factor of reduced clopidogrel efficacy in elderly patients with stable coronary artery disease?
Topics: Aged, 80 and over; Blood Platelets; Clopidogrel; Coronary Artery Disease; Creatinine; Female; Hemoglobins; Humans; Male; Odds Ratio; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Regression Analysis; Renal Insufficiency, Chronic; Risk Factors; Ticlopidine; Treatment Outcome | 2013 |
The impact of triple anti-platelet therapy for endothelialization and inflammatory response at overlapping bioabsorbable polymer coated drug-eluting stents in a porcine coronary model.
Topics: Absorbable Implants; Animals; Aspirin; Cilostazol; Clopidogrel; Coated Materials, Biocompatible; Coronary Restenosis; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Drug-Eluting Stents; Female; Inflammation; Neointima; Platelet Aggregation Inhibitors; Polymers; Swine; Tetrazoles; Ticlopidine; Treatment Outcome | 2013 |
Formation, reactivity, and antiplatelet activity of mixed disulfide conjugates of clopidogrel.
Topics: Animals; Blood Platelets; Clopidogrel; Disulfides; Male; Platelet Aggregation Inhibitors; Rabbits; Ticlopidine | 2013 |
[Comment of the Delphi Care editors on Critical evaluation of interaction screening software available in pharmacies].
Topics: Anti-Bacterial Agents; Aromatase Inhibitors; Clopidogrel; Contraceptives, Oral; Delphi Technique; Drug Interactions; Estrogens; Female; Humans; Omeprazole; Pharmacies; Pharmacists; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Software; Ticlopidine | 2012 |
Characterization of aspirin allergies in patients with coronary artery disease.
Topics: Aged; Aged, 80 and over; Aspirin; California; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Hypersensitivity; Female; Humans; Male; Retrospective Studies; Ticlopidine | 2013 |
[Reversible ageusia associated with clopidogrel use].
Topics: Ageusia; Astringents; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Zinc Sulfate | 2012 |
Reversible cerebral vasoconstriction syndrome and bilateral vertebral artery dissection presenting in a patient after cesarean section.
Topics: Aspirin; Cerebral Angiography; Cesarean Section; Clopidogrel; Female; Headache; Humans; Magnetic Resonance Imaging; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Syndrome; Ticlopidine; Tomography, X-Ray Computed; Vasoconstriction; Vasospasm, Intracranial; Vertebral Artery Dissection | 2013 |
Establishment of a CYP2C19 genotyping assay for clinical use.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Genome, Human; Genotype; Genotyping Techniques; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2013 |
Acute myocardial infarction and heart block: a challenge to emergency physicians.
Topics: Aspirin; Clopidogrel; Electrocardiography; Enoxaparin; Fibrinolytic Agents; Heart Block; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Thrombolytic Therapy; Ticlopidine | 2013 |
Factors that contribute to clopidogrel resistance in cardiovascular disease patients: environmental and genetic approach.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Cardiovascular Diseases; Cholesterol, HDL; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2013 |
Thrombocytopenia induced by both aspirin and clopidogrel in the same patient.
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Thrombocytopenia; Ticlopidine | 2013 |
Risk of adverse cardiovascular outcomes and all-cause mortality associated with concomitant use of clopidogrel and proton pump inhibitors in elderly patients.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Lansoprazole; Male; Myocardial Infarction; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Risk; Stroke; Ticlopidine | 2013 |
[Analysis of the risk factors of patients with acute coronary syndrome suffering hemorrhage during hospitalization].
Topics: Acute Coronary Syndrome; Age of Onset; Aged; Clopidogrel; Female; Hemorrhage; Hospitalization; Humans; Incidence; Logistic Models; Male; Middle Aged; Platelet Glycoprotein GPIIb-IIIa Complex; Renal Insufficiency; Risk Factors; Ticlopidine | 2012 |
[Clopidogrel metabolism related gene polymorphisms in Chinese patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Ticlopidine | 2012 |
Cerebroprotective effect of preoperative dual antiplatelet therapy in patients undergoing coronary bypass surgery.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cardiopulmonary Bypass; Clopidogrel; Cognition; Cognition Disorders; Coronary Artery Bypass; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Platelet Aggregation Inhibitors; Predictive Value of Tests; Principal Component Analysis; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Cardiovascular risk among patients on clopidogrel anti-platelet therapy after placement of drug-eluting stents is modified by genetic variants in both the CYP2C19 and ABCB1 genes.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prosthesis Design; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Unclassified pleomorphic and spindle cell pulmonary neoplasm with brain metastases after prasugrel.
Topics: Aged; Aspirin; Brain Neoplasms; Carcinoma; Clinical Trials, Phase III as Topic; Clopidogrel; Colonic Neoplasms; Coronary Stenosis; Diabetes Mellitus, Type 1; Diabetic Cardiomyopathies; Drug Therapy, Combination; Drug-Eluting Stents; Fatal Outcome; Female; Humans; Lung Neoplasms; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Ticlopidine; Time Factors | 2013 |
Effects of high loading dose of clopidogrel in ST elevated myocardial infarction treated with fibrinolytic agent.
Topics: Aged; C-Reactive Protein; Clopidogrel; Drug Administration Schedule; Electrocardiography; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Myocardial Infarction; Ticlopidine | 2013 |
Safety of clopidogrel in hip fracture surgery.
Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Case-Control Studies; Clopidogrel; Cohort Studies; Female; Hip Fractures; Humans; Male; Minnesota; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Postoperative Period; Retrospective Studies; Ticlopidine; Treatment Outcome | 2013 |
Clopidogrel-associated vasculopathic cutaneous reaction.
Topics: Aged; Biopsy; Clopidogrel; Fibrin; Fingers; Gangrene; Humans; Male; Platelet Aggregation Inhibitors; Skin; Thrombosis; Ticlopidine | 2013 |
A case of in-stent thrombosis in a patient with drug eluting stents during perioperative management with glycoprotein IIb/IIIa inhibitors.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Thrombosis; Drug Substitution; Drug Therapy, Combination; Drug-Eluting Stents; Eptifibatide; Female; Humans; Neurosurgical Procedures; Peptides; Percutaneous Coronary Intervention; Perioperative Period; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Interventional | 2013 |
Clopidogrel, CYP2C19, and a Black Box.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Drug Labeling; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Influence of oral antiplatelet therapy on hemorrhagic complications of pacemaker implantation.
Topics: Administration, Oral; Aged; Aspirin; Biomarkers; Blood Transfusion; Cardiac Pacing, Artificial; Clopidogrel; Drug Therapy, Combination; Female; Germany; Hematoma; Hemoglobins; Humans; Incidence; Logistic Models; Male; Middle Aged; Odds Ratio; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
The use of flow diverter stents in the management of traumatic vertebral artery dissections.
Topics: Accidental Falls; Aged; Angiography; Anticoagulants; Aspirin; Clopidogrel; Endovascular Procedures; Heparin; Humans; Platelet Aggregation Inhibitors; Regional Blood Flow; Stents; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Vertebral Artery Dissection | 2013 |
Comparing the safety of ticagrelor versus clopidogrel: insights from the FDA reports.
Topics: Adenosine; Cardiovascular Diseases; Clopidogrel; Humans; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2013 |
CYP3A4 genetic status may be associated with increased vulnerability to the inhibitory effect of calcium-channel blockers on clopidogrel.
Topics: Aged; Blood Platelets; Calcium Channel Blockers; Chi-Square Distribution; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Gene Frequency; Genotype; Humans; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine | 2013 |
The power of more than one.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2013 |
The impact of CYP2C19 genotype on cardiovascular events and platelet reactivity in patients with coronary artery disease receiving clopidogrel.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Platelet antiaggregation therapy and subinguinal endovascular revascularization.
Topics: Aged; Aged, 80 and over; Clopidogrel; Endovascular Procedures; Humans; Ischemia; Lower Extremity; Medication Adherence; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Pain-associated respiratory failure in chest trauma.
Topics: Aged; Chest Pain; Clopidogrel; Humans; Male; Respiratory Insufficiency; Thoracic Injuries; Ticlopidine | 2013 |
Periprocedural prophylactic antithrombotic strategies in interventional radiology: current practice in the Netherlands and comparison with the United kingdom.
Topics: Clopidogrel; Fibrinolytic Agents; Heparin; Humans; Netherlands; Perioperative Care; Practice Patterns, Physicians'; Radiology, Interventional; Stents; Surveys and Questionnaires; Thrombosis; Ticlopidine; United Kingdom; Vascular Surgical Procedures | 2013 |
Upper limb regional anaesthesia and altered coagulation function.
Topics: Anesthesia, Conduction; Blood Coagulation; Clopidogrel; Guidelines as Topic; Health Care Surveys; Humans; International Normalized Ratio; Platelet Aggregation Inhibitors; Platelet Count; Ticlopidine; Ultrasonography, Interventional; United Kingdom; Upper Extremity | 2013 |
Risk of traumatic intracranial hemorrhage in patients with head injury and preinjury warfarin or clopidogrel use.
Topics: Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Craniocerebral Trauma; Female; Humans; Incidence; Intracranial Hemorrhage, Traumatic; Male; Middle Aged; Platelet Aggregation Inhibitors; Prevalence; Prospective Studies; Risk Factors; Ticlopidine; Tomography, X-Ray Computed; Warfarin | 2013 |
Exploring the ticagrelor-statin interplay in the PLATO trial.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials, Phase III as Topic; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Simvastatin; Ticagrelor; Ticlopidine | 2013 |
Clopidogrel responsiveness in patients undergoing peripheral angioplasty.
Topics: Aged; Angioplasty; Clopidogrel; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Limb Salvage; Male; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Survival Analysis; Ticlopidine; Treatment Outcome; Vascular Patency | 2013 |
Amplatzer left atrial appendage occlusion: single center 10-year experience.
Topics: Aged; Aged, 80 and over; Anesthesia, Local; Aspirin; Atrial Appendage; Atrial Fibrillation; Cardiac Catheterization; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Radiography, Interventional; Retrospective Studies; Stroke; Switzerland; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Dual or single antiplatelet therapy with anticoagulation?
Topics: Anticoagulants; Aspirin; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Long-term outcome after angiographically proven coronary stent thrombosis.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug-Eluting Stents; Electrocardiography; Female; Follow-Up Studies; Germany; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Prognosis; Prosthesis Failure; Registries; Retrospective Studies; Risk Factors; Shock, Cardiogenic; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Paraoxonase 1 gene polymorphism does not affect clopidogrel response variability but is associated with clinical outcome after PCI.
Topics: Aged; Aged, 80 and over; Aryldialkylphosphatase; Clopidogrel; Coronary Artery Disease; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Risk Factors; Stents; Ticlopidine | 2013 |
It's for your benefit: exploring patients' opinions about the inclusion of textual and numerical benefit information in medicine leaflets.
Topics: Aged; Aged, 80 and over; Australia; Clopidogrel; Comprehension; Drug Labeling; Female; Focus Groups; Humans; Male; Medication Adherence; Middle Aged; Numbers Needed To Treat; Pamphlets; Patient Education as Topic; Patient Preference; Ticlopidine; United Kingdom | 2013 |
High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition.
Topics: Adenosine; Animals; Arachidonic Acid; Aspirin; Clopidogrel; Dogs; Dose-Response Relationship, Drug; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor; Ticlopidine; Vascular Resistance | 2013 |
[3-year follow-up after endovascular aneurysm treatment with Silk® flow diverter].
Topics: Adult; Aged; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Equipment Design; Female; Humans; Intracranial Aneurysm; Magnetic Resonance Angiography; Male; Middle Aged; Platelet Aggregation Inhibitors; Premedication; Recurrence; Retreatment; Stents; Surgical Instruments; Ticlopidine; Tomography, X-Ray Computed | 2013 |
SILK flow diverter for treatment of intracranial aneurysms: initial experience and cost analysis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Clopidogrel; Coronary Angiography; Costs and Cost Analysis; Databases, Factual; Dexamethasone; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Magnetic Resonance Angiography; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Young Adult | 2013 |
Cardiac magnetic resonance detection of left ventricular thrombus in acute myocardial infarction.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Echocardiography; Female; Humans; Incidence; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Stroke Volume; Thrombosis; Ticlopidine; Ventricular Dysfunction, Left; Warfarin | 2013 |
Duration of dual antiplatelet therapy after implantation of the first-generation and second-generation drug-eluting stents.
Topics: Aged; Aspirin; Cardiovascular Agents; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Disease-Free Survival; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prosthesis Design; Retrospective Studies; Risk Assessment; Risk Factors; Sirolimus; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Balancing thrombotic and bleeding risks related to antiplatelet therapy in coronary bypass surgery: Comment on "Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting".
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; Tranexamic Acid | 2013 |
PCI patients taking oral anticoagulants may not need aspirin.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; Atrial Flutter; Clopidogrel; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine; Treatment Outcome | 2013 |
[Is antiplatelet therapy always effective?].
Topics: Adult; Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Treatment Outcome | 2012 |
Switching acute coronary syndrome patients from prasugrel to clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Chi-Square Distribution; Clopidogrel; Drug Resistance; Drug Substitution; Female; Hemorrhage; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Risk Assessment; Risk Factors; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Switching from prasugrel to clopidogrel: navigating in unknown waters.
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Drug Substitution; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2013 |
Pharmacological interactions: the next frontier?
Topics: Atorvastatin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Pyrroles; Ticlopidine | 2013 |
Cilostazol for primary prevention of stroke in peripheral artery disease: a population-based longitudinal study in Taiwan.
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Cohort Studies; Female; Humans; Longitudinal Studies; Male; Peripheral Arterial Disease; Retrospective Studies; Risk Factors; Stroke; Taiwan; Tetrazoles; Ticlopidine; Vasodilator Agents | 2013 |
Invited commentary.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Humans; Male; Ticlopidine; Tranexamic Acid | 2013 |
Comparative effect of clopidogrel plus aspirin and aspirin monotherapy on hematological parameters using propensity score matching.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Erythrocyte Count; Female; Hematocrit; Hemoglobins; Humans; Leukocyte Count; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Propensity Score; Risk Factors; Ticlopidine; Treatment Outcome | 2013 |
Vertebral artery dissection associated with sildenafil abuse.
Topics: Anticoagulants; Cerebral Infarction; Clopidogrel; Heparin; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Purines; Sildenafil Citrate; Sulfones; Ticlopidine; Treatment Outcome; Ultrasonography; Vasodilator Agents; Vertebral Artery Dissection | 2013 |
Prasugrel use in a patient allergic to clopidogrel: effect of a drug shortage on selection of dual antiplatelet therapy.
Topics: Aged; Clopidogrel; Drug Hypersensitivity; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2013 |
Mutational analysis clopidogrel resistance and platelet function in patients scheduled for coronary artery bypass grafting.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Case-Control Studies; Clopidogrel; Coronary Artery Bypass; Cytochrome P-450 CYP2C19; DNA Mutational Analysis; Drug Resistance; Female; Genetic Association Studies; Heart Diseases; Humans; Male; Middle Aged; Mutation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2013 |
A Boolean view separates platelet activatory and inhibitory signalling as verified by phosphorylation monitoring including threshold behaviour and integrin modulation.
Topics: Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Hemorrhage; Humans; Iloprost; Integrins; Milrinone; Models, Biological; Molecular Dynamics Simulation; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Ticlopidine | 2013 |
The duel between dual antiplatelet therapies.
Topics: Adenosine Monophosphate; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Myocardial Ischemia; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2013 |
Thrombocytopenia, dual antiplatelet therapy, and heparin bridging strategy increase pocket hematoma complications in patients undergoing cardiac rhythm device implantation.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; China; Clopidogrel; Cross-Sectional Studies; Defibrillators, Implantable; Drug Therapy, Combination; Female; Hematoma; Heparin; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Risk Factors; Thrombocytopenia; Ticlopidine; Warfarin | 2013 |
CYP2C19 genetic polymorphism, rabeprazole and esomeprazole have no effect on the antiplatelet action of clopidogrel.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Esomeprazole; Female; Genotype; Humans; In Vitro Techniques; Logistic Models; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Proton Pump Inhibitors; Rabeprazole; Ticlopidine | 2013 |
Ask the doctor. I need surgery for a gastrointestinal problem, and my question is how to handle my antiplatelet therapy, which I have been taking for two years since I had angioplasty. I take aspirin and clopidogrel, which were started after I had a hea
Topics: Aspirin; Clopidogrel; Contraindications; Digestive System Surgical Procedures; Dose-Response Relationship, Drug; Gastrointestinal Diseases; Humans; Platelet Aggregation Inhibitors; Preoperative Care; Stents; Ticlopidine; Withholding Treatment | 2012 |
[Gastrointestinal bleeding after treatment with ticagrelor].
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Coronary Artery Bypass; Female; Gastrointestinal Hemorrhage; Humans; Pulmonary Disease, Chronic Obstructive; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Low prevalence of clopidogrel and acetylsalicylic acid resistance in patients with acute myocardial infarction and pantoprazole treatment in everyday practice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; General Practice; Humans; Male; Middle Aged; Myocardial Infarction; Pantoprazole; Platelet Aggregation Inhibitors; Prevalence; Ticlopidine; Treatment Outcome | 2013 |
[Aneurysm of abdominal aorta rupture in a patient on dabigatran treatment].
Topics: Aged; Antithrombins; Aortic Aneurysm, Abdominal; Aortic Rupture; Arrhythmias, Cardiac; Aspirin; Benzimidazoles; beta-Alanine; Blood Transfusion, Autologous; Clopidogrel; Dabigatran; Humans; Male; Plasma; Platelet Aggregation Inhibitors; Platelet Transfusion; Shock, Hemorrhagic; Ticlopidine | 2013 |
Cross-modulatory effects of clopidogrel and heparin on platelet and fibrin incorporation in thrombosis.
Topics: Animals; Anticoagulants; Blood Coagulation; Blood Platelets; Clopidogrel; Disease Models, Animal; Drug Interactions; Fibrin; Heparin; Male; Mice; Mice, Inbred C57BL; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Venous Thrombosis | 2013 |
Hypertension as a risk factor for aspirin and clopidogrel resistance in patients with stable coronary artery disease.
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Humans; Hypertension; Male; Mean Platelet Volume; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Count; Risk Factors; Stents; Ticlopidine | 2014 |
Effects of coexisting polymorphisms of CYP2C19 and P2Y12 on clopidogrel responsiveness and clinical outcome in patients with acute coronary syndromes undergoing stent-based coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Middle Aged; Mutation; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Ticlopidine | 2013 |
Quantitative assessment of late lumen loss after biodegradable polymer and permanent polymer sirolimus-eluting stents implantation.
Topics: Aged; Aspirin; Clopidogrel; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Polymers; Regression Analysis; Sirolimus; Ticlopidine | 2013 |
Influence of CYP2C19*2 and *3 loss-of-function alleles on the pharmacodynamic effects of standard- and high-dose clopidogrel in East Asians undergoing percutaneous coronary intervention: the results of the ACCEL-DOUBLE-2N3 study.
Topics: Adenosine Diphosphate; Adult; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Female; Genotype; Heterozygote; Humans; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Pharmacogenetics; Pilot Projects; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Ticlopidine | 2013 |
Triple therapy with aspirin, prasugrel, and vitamin K antagonists in patients with drug-eluting stent implantation and an indication for oral anticoagulation.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Patient Selection; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Vitamin K | 2013 |
Tailoring antiplatelet therapy--insanity or good sense?
Topics: Asian People; Clopidogrel; Humans; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2013 |
Glucose intolerance and insulin resistance as predictors of low platelet response to clopidogrel in patients with minor ischemic stroke or TIA.
Topics: Aged; Blood Glucose; Blood Platelets; Clopidogrel; Female; Glucose Intolerance; Humans; Insulin Resistance; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Ticlopidine; Treatment Outcome | 2014 |
Thiolactone sulfoxides as new reactive metabolites acting as bis-electrophiles: implication in clopidogrel and prasugrel bioactivation.
Topics: Clopidogrel; Cytochrome P-450 Enzyme System; Humans; Lactones; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Piperazines; Prasugrel Hydrochloride; Prodrugs; Sulfoxides; Thiophenes; Ticlopidine | 2013 |
Safety and efficacy of intense antithrombotic treatment and percutaneous coronary intervention deferral in patients with large intracoronary thrombus.
Topics: Acute Coronary Syndrome; Angiography; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Coronary Thrombosis; Enoxaparin; Humans; Inpatients; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prospective Studies; Thrombectomy; Thrombolytic Therapy; Ticlopidine | 2013 |
The effect of fibrin clot inhibitors on the immunomodulatory efficacy of Bacillus Calmette-Guérin therapy for non-muscle-invasive bladder cancer.
Topics: Adjuvants, Immunologic; Aged; Aged, 80 and over; Anticoagulants; Aspirin; BCG Vaccine; Clopidogrel; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Humans; Immunomodulation; Induction Chemotherapy; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Odds Ratio; Proportional Hazards Models; Retrospective Studies; Ticlopidine; Urinary Bladder Neoplasms; Warfarin | 2013 |
Thiazolidinedione usage is associated with decreased response to clopidogrel in DM patients.
Topics: Aged; Clopidogrel; Cohort Studies; Diabetes Mellitus; Drug Interactions; Female; Humans; Male; Middle Aged; Prospective Studies; Registries; Thiazolidinediones; Ticlopidine; Treatment Outcome | 2013 |
[Assessment of clinical and antiaggregation efficacy of generic clopidogrel 'Egithromb' in roentgenosurgical practice].
Topics: Angina Pectoris; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Dose-Response Relationship, Drug; Drug Resistance; Drugs, Generic; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Therapeutic Equivalency; Ticlopidine; Treatment Outcome | 2013 |
Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion.
Topics: Aspirin; Biological Assay; Blood Platelets; Cells, Cultured; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation, Preclinical; Flow Injection Analysis; Humans; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Shear Strength; Surface Properties; Ticlopidine; Treatment Outcome | 2013 |
Tailored Thienopyridine therapy: no urgency for CYP2C19 genotyping.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotyping Techniques; Humans; Pharmacogenetics; Polymorphism, Genetic; Precision Medicine; Purinergic P2Y Receptor Antagonists; Thienopyridines; Ticlopidine | 2013 |
Correlation of platelet reactivity and C-reactive protein levels to occurrence of peri-procedural myocardial infarction in patients undergoing percutaneous coronary intervention (from the ARMYDA-CRP study).
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Biomarkers; C-Reactive Protein; Clopidogrel; Female; Humans; Incidence; Italy; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Risk Factors; Sensitivity and Specificity; Ticlopidine; Treatment Outcome | 2013 |
Short-term bleeding events observed with clopidogrel loading in acute ischemic stroke patients.
Topics: Aged; Brain Ischemia; Clopidogrel; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2013 |
A validated HPLC-MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: application to a clinical pharmacokinetic study.
Topics: Chromatography, High Pressure Liquid; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Tandem Mass Spectrometry; Ticlopidine | 2013 |
Lifetime cost-effectiveness analysis of ticagrelor in patients with acute coronary syndromes based on the PLATO trial: a Singapore healthcare perspective.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clinical Trials as Topic; Clopidogrel; Cost-Benefit Analysis; Decision Trees; Drug Costs; Humans; Markov Chains; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Quality-Adjusted Life Years; Republic of Korea; Singapore; Ticagrelor; Ticlopidine | 2013 |
Spontaneous hematomas.
Topics: Aspirin; Clopidogrel; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Hematoma; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
[Effect of intracoronary and intravenous administration of tirofiban loading dose in patients underwent percutaneous coronary interventions because of acute coronary syndrome].
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Monitoring; Electrocardiography; Female; Hemorrhage; Humans; Length of Stay; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Preoperative Care; Retrospective Studies; Survival Analysis; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine | 2013 |
Soluble P-selectin level correlates with acetylsalicylic acid but not with clopidogrel response in patients with stable coronary artery disease after a percutaneous coronary intervention.
Topics: Aged; Anti-Inflammatory Agents; Aryl Hydrocarbon Hydroxylases; Aspirin; CD40 Ligand; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Microfilament Proteins; Middle Aged; P-Selectin; Percutaneous Coronary Intervention; Phosphoproteins; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2013 |
CYP2C19 phenotype, stent thrombosis, myocardial infarction, and mortality in patients with coronary stent placement in a Chinese population.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Expression; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Postoperative Hemorrhage; Stents; Survival Analysis; Thrombosis; Ticlopidine | 2013 |
CYP2C19 polymorphism and antiplatelet effects of clopidogrel in Chinese stroke patients.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Asian People; China; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; DNA; Female; Genotype; Humans; Isoenzymes; Linear Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stroke; Ticlopidine; Young Adult | 2013 |
Is discontinuation of clopidogrel necessary for intracapsular hip fracture surgery? Analysis of 102 hemiarthroplasties.
Topics: Aged; Aged, 80 and over; Blood Transfusion; Clopidogrel; Comorbidity; Databases, Factual; Female; Hemiarthroplasty; Hemorrhage; Hip Fractures; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2013 |
Prophylactic effect of egualen sodium, a stable azulene derivative, on gastrointestinal damage induced by ischemia/reperfusion, double antiplatelet therapy and loxoprofen in rats.
Topics: Animals; Aspirin; Azulenes; Benzoquinones; Clopidogrel; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastrointestinal Tract; Heptanoic Acids; Male; Mice; Mice, Inbred C57BL; Mucus; Nitric Oxide Synthase Type II; Peptic Ulcer; Peroxidase; Phenylpropionates; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sesquiterpenes; Ticlopidine | 2013 |
How important is preventing platelet activation in the setting of percutaneous coronary intervention?
Topics: Animals; Clopidogrel; Drug Synergism; Humans; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Ticlopidine | 2004 |
Influence of genetic polymorphisms on platelet function, response to antiplatelet drugs and clinical outcomes in patients with coronary artery disease.
Topics: Adenosine; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Aspirin; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Humans; Pharmacogenetics; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Bleeding complications during percutaneous coronary intervention.
Topics: Abciximab; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Anticoagulants; Aspirin; Clopidogrel; Hemorrhage; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Immunoglobulin Fab Fragments; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Ticlopidine | 2004 |
Here and now--state of the art: optimal antithrombotic strategy for percutaneous coronary intervention-panel discussion.
Topics: Angioplasty, Balloon, Coronary; Antithrombins; Clopidogrel; Drug-Eluting Stents; Humans; Stents; Ticlopidine | 2004 |
Questions and answers on treating acute myocardial infarction.
Topics: Cardiac Catheterization; Clopidogrel; Decision Making; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recombinant Proteins; Thrombolytic Therapy; Ticlopidine; Time-to-Treatment; Tissue Plasminogen Activator | 2004 |
[Your patient needs antithrombotics, 2. What do the new substances offer? (interview by Dr. med. Peter Stiefelhagen)].
Topics: Adenosine; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Cardiovascular Diseases; Clopidogrel; Dabigatran; Fibrinolytic Agents; Guideline Adherence; Humans; Morpholines; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyrazoles; Pyridones; Rivaroxaban; Thiophenes; Thromboembolism; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Thrombocytosis as a potential cause of a very late stent thrombosis in the left main coronary artery.
Topics: Adult; Clopidogrel; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Drug-Eluting Stents; Humans; Male; Myocardial Infarction; Out-of-Hospital Cardiac Arrest; Paclitaxel; Thrombocytosis; Ticlopidine; Withholding Treatment | 2013 |
Operative treatment of hip fractures in patients on clopidogrel: a case-control study.
Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Blood Transfusion; Case-Control Studies; Clopidogrel; Female; Hemorrhage; Hip Fractures; Humans; Intraoperative Period; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Ticlopidine | 2012 |
Spontaneous haemorrhage in an eyelid hidrocystoma in a patient treated with clopidogrel.
Topics: Clopidogrel; Diagnosis, Differential; Eyelid Neoplasms; Female; Hemorrhage; Hidrocystoma; Humans; Middle Aged; Platelet Aggregation Inhibitors; Sweat Gland Neoplasms; Ticlopidine | 2013 |
Using Leo Plus stent as flow diverter and endoluminal remodeling in endovascular treatment of intracranial fusiform aneurysms.
Topics: Adult; Aged; Anesthesia, General; Aneurysm; Angiography, Digital Subtraction; Aspirin; Blepharoptosis; Cerebral Angiography; Clopidogrel; Diplopia; Endovascular Procedures; Feasibility Studies; Female; Headache; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Middle Aged; Neurologic Examination; Platelet Aggregation Inhibitors; Posterior Cerebral Artery; Retrospective Studies; Stents; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2013 |
Ticagrelor improves peripheral arterial function in patients with a previous acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Blood Pressure; Case-Control Studies; Clopidogrel; Endothelium, Vascular; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Peripheral Arterial Disease; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Variability of platelet responses to adenosine diphosphate.
Topics: Blood Platelets; Clopidogrel; Coronary Disease; Down-Regulation; Female; Humans; Male; MicroRNAs; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
[Influence of the combination of antiplatelet agents on the occurrence of early left ventricular insufficiency in patients with acute coronary syndromes without persistent ST-segment elevation].
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine; Tirofiban; Treatment Outcome; Tyrosine; Ventricular Dysfunction, Left | 2014 |
High on-treatment platelet reactivity predicts cardiac events in patients with drug-eluting stents.
Topics: Aged; Brazil; Cardiovascular Diseases; Clopidogrel; Drug-Eluting Stents; Epidemiologic Methods; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Standards; Risk Factors; Ticlopidine | 2013 |
Platelet responsiveness to clopidogrel treatment after peripheral endovascular procedures: the PRECLOP study: clinical impact and optimal cutoff value of on-treatment high platelet reactivity.
Topics: Aged; Blood Platelets; Clopidogrel; Disease-Free Survival; Endovascular Procedures; Female; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Reproducibility of Results; ROC Curve; Sensitivity and Specificity; Stents; Ticlopidine; Treatment Outcome | 2013 |
Feasibility of a microarray-based point-of-care CYP2C19 genotyping test for predicting clopidogrel on-treatment platelet reactivity.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Microarray Analysis; Platelet Count; Point-of-Care Systems; Polymorphism, Genetic; Precision Medicine; Ticlopidine | 2013 |
Association of PON1 genotype and haplotype with susceptibility to coronary artery disease and clinical outcomes in dual antiplatelet-treated Han Chinese patients.
Topics: Aged; Aryldialkylphosphatase; Asian People; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Promoter Regions, Genetic; Ticlopidine; Treatment Outcome | 2013 |
Antiplatelet therapy. Cangrelor succeeds, at last, in PCI.
Topics: Adenosine Monophosphate; Administration, Intravenous; Administration, Oral; Blood Platelets; Clopidogrel; Coronary Thrombosis; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2013 |
Is platelet transfusion efficient to restore platelet reactivity in patients who are responders to aspirin and/or clopidogrel before emergency surgery?
Topics: Aspirin; Blood Platelets; Clopidogrel; Hemorrhage; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Transfusion; Prospective Studies; Ticlopidine; Wounds and Injuries | 2013 |
Preserved thrombin-inducible platelet activation in thienopyridine-treated patients.
Topics: Adenosine Diphosphate; Aged; Angioplasty; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Female; Humans; Integrin beta3; Male; Middle Aged; P-Selectin; Peptide Fragments; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Thrombin; Ticlopidine | 2013 |
Cytochrome P450 2B6 and 2C9 genotype polymorphism--a possible cause of prasugrel low responsiveness.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Biomarkers, Pharmacological; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C9; Drug Resistance; Drug Therapy, Combination; Female; Gene Frequency; Genetic Association Studies; Genotype; Humans; Male; Middle Aged; Piperazines; Polymorphism, Genetic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2013 |
Clopidogrel pretreatment in primary percutaneous coronary intervention: prevalence of high on-treatment platelet reactivity and impact on preprocedural patency of the infarct-related artery.
Topics: Arteries; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Preoperative Care; Prevalence; Prospective Studies; Ticlopidine; Vascular Patency | 2013 |
Response to antiplatelet therapy is independent of endogenous thrombin generation potential.
Topics: Aged; Angioplasty; Aspirin; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thrombin; Ticlopidine | 2013 |
Bleeding outcomes associated with coronary artery bypass graft surgery and recent clopidogrel exposure.
Topics: Causality; Clopidogrel; Comorbidity; Coronary Artery Bypass; Drug-Related Side Effects and Adverse Reactions; Female; Hospital Mortality; Humans; Male; Middle Aged; Ohio; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prevalence; Retrospective Studies; Risk Assessment; Survival Analysis; Survival Rate; Ticlopidine; Treatment Outcome | 2013 |
Cost-effectiveness of universal and platelet reactivity assay-driven antiplatelet therapy in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Cohort Studies; Cost-Benefit Analysis; Decision Trees; Dose-Response Relationship, Drug; Drug Costs; Drug Therapy, Combination; Drugs, Generic; Female; Humans; Male; Markov Chains; Myocardial Revascularization; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Quality-Adjusted Life Years; Receptors, Purinergic P2Y12; Survival Rate; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Anti-thrombotic treatment in patients with a long-term indication for anticoagulant therapy undergoing coronary stenting.
Topics: Anticoagulants; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2013 |
CYP2C19 polymorphisms and antiplatelet effects of clopidogrel in acute ischemic stroke in China.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Asian People; Case-Control Studies; China; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Follow-Up Studies; Genetic Testing; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prognosis; Stroke; Ticlopidine; Treatment Outcome | 2013 |
Newly identified synergy between clopidogrel and calcium-channel blockers for blood pressure regulation possibly involves CYP2C19 rs4244285.
Topics: Adult; Aged; Angina, Unstable; Aryl Hydrocarbon Hydroxylases; Blood Pressure; Calcium Channel Blockers; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Synergism; Female; Humans; Male; Middle Aged; Myocardial Infarction; Ticlopidine | 2013 |
A coronary pseudoaneurysm within a restenotic stent treated by implantation of a pericardium-covered stent and drug-eluting balloon.
Topics: Aneurysm, False; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Drug Therapy, Combination; Female; Humans; Middle Aged; Paclitaxel; Pericardium; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2013 |
Aspirin desensitisation for Chinese patients with coronary artery disease.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Desensitization, Immunologic; Drug Hypersensitivity; Drug-Eluting Stents; Female; Hong Kong; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Time Factors | 2013 |
Safety and effectiveness of Thulium VapoEnucleation of the prostate (ThuVEP) in patients on anticoagulant therapy.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Clopidogrel; Hemorrhage; Humans; Incidence; Male; Minimally Invasive Surgical Procedures; Prostatectomy; Prostatic Hyperplasia; Retrospective Studies; Thulium; Ticlopidine; Treatment Outcome; Urinary Tract Infections; Venous Thrombosis | 2014 |
Relationship between aspirin/clopidogrel resistance and intra-stent thrombi assessed by follow-up optical coherence tomography after drug-eluting stent implantation.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Cohort Studies; Confidence Intervals; Coronary Angiography; Coronary Thrombosis; Drug Resistance; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Prosthesis Failure; Retrospective Studies; Risk Assessment; Severity of Illness Index; Thrombosis; Ticlopidine; Tomography, Optical Coherence; Treatment Outcome | 2013 |
The impact of direct healthcare professional communication on prescribing practice in the UK hospital setting: an interrupted time series analysis.
Topics: Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Clopidogrel; Communication; Dementia; Drug Interactions; Drug Prescriptions; Health Personnel; Hospitals; Humans; Omeprazole; Practice Patterns, Physicians'; Proton Pump Inhibitors; Ticlopidine; United Kingdom | 2013 |
Antiplatelet therapy at the time of coronary artery bypass grafting: a multicentre cohort study.
Topics: Aged; Analysis of Variance; Aspirin; Blood Transfusion; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Denmark; Female; Hospitals, University; Humans; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Thrombosis; Ticlopidine | 2013 |
CYP2C19 genotypes and their impact on clopidogrel responsiveness in percutaneous coronary intervention.
Topics: Adult; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Genotype; Humans; Malaysia; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Prevalence; Ticlopidine; Treatment Outcome | 2013 |
Platelet function testing to predict hyporesponsiveness to clopidogrel in patients with chest pain seen in the emergency department.
Topics: Age Factors; Aged; Black or African American; Blood Platelets; Chest Pain; Clopidogrel; Diabetes Mellitus, Type 2; Drug Resistance; Drug Therapy, Combination; Emergency Service, Hospital; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Sex Factors; Stents; Ticlopidine; Treatment Outcome | 2013 |
Challenging ticagrelor's claimed reduction in the rate of definite stent thrombosis versus clopidogrel: insights from the FDA reports.
Topics: Adenosine; Clopidogrel; Drug-Eluting Stents; Humans; Randomized Controlled Trials as Topic; Thrombosis; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2013 |
Clopidogrel does not work following cardiopulmonary resuscitation.
Topics: Biological Availability; Cardiopulmonary Resuscitation; Clopidogrel; Humans; Hypothermia, Induced; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2013 |
Spontaneous platelet aggregation in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Alprostadil; Antibodies; Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Ticlopidine; von Willebrand Factor | 2013 |
[Interview with the Daiichi-Sankyo managing director Ralf Göddertz (interview by Dirk Einecke and Cornelius Heyer)].
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Cost Savings; Cost-Benefit Analysis; Drug Costs; Drug Industry; Drugs, Generic; Forecasting; Germany; Humans; National Health Programs; Patents as Topic; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Combined and independent impact of diabetes mellitus and chronic kidney disease on residual platelet reactivity.
Topics: Aged; Clopidogrel; Diabetes Complications; Diabetes Mellitus; Female; Humans; Kidney Diseases; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Function Tests; Preoperative Care; Prospective Studies; Receptors, Purinergic P2Y12; Risk; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Proton-pump inhibitors can decrease gastrointestinal bleeding after percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Alcohol Drinking; Angina, Stable; Aspirin; Case-Control Studies; Clopidogrel; Female; Gastrointestinal Hemorrhage; Humans; Male; Peptic Ulcer; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Sex Factors; Smoking; Ticlopidine | 2013 |
Direct measurement of active thiol metabolite levels of clopidogrel in human plasma using tris(2-carboxyethyl)phosphine as a reducing agent by LC-MS/MS.
Topics: Chromatography, Liquid; Clopidogrel; Humans; Oxidation-Reduction; Phosphines; Sulfhydryl Compounds; Tandem Mass Spectrometry; Ticlopidine | 2013 |
Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Aged, 80 and over; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Hospitalization; Hospitals, Veterans; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; Retrospective Studies; Ticlopidine; Treatment Outcome | 2013 |
Perioperative management of a neurosurgical patient with a meningioma and recent coronary artery stent.
Topics: Aged; Aspirin; Blood Loss, Surgical; Clopidogrel; Contraindications; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Meningioma; Perioperative Care; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2013 |
Abciximab bolus with optional infusion in intervention for ST-elevation myocardial infarction.
Topics: Abciximab; Aged; Aged, 80 and over; Antibodies, Monoclonal; Clopidogrel; Coronary Thrombosis; Cost Savings; Cost-Benefit Analysis; Drug Administration Schedule; Drug Costs; Drug Therapy, Combination; Female; Hemorrhage; Humans; Immunoglobulin Fab Fragments; Infusions, Parenteral; Injections; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recurrence; Registries; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Efffect of the ABCC3 -211C/T polymorphism on clopidogrel responsiveness in patients with percutaneous coronary intervention.
Topics: Aged; Clopidogrel; Female; Gene Expression Regulation; Genotype; Humans; Logistic Models; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2013 |
Effect of platelet inhibition on bleeding complications in trauma patients on preinjury clopidogrel.
Topics: Adult; Blood Platelets; Clopidogrel; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Purinergic P2Y12; Retrospective Studies; Ticlopidine; Wounds and Injuries | 2013 |
Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update.
Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Genetic Variation; Genotype; Humans; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine | 2013 |
ED administration of thienopyridines in non-ST-segment elevation myocardial infarction: results from the NCDR.
Topics: Aged; Clopidogrel; Drug Administration Schedule; Emergency Service, Hospital; Female; Hemorrhage; Hospital Mortality; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Registries; Retrospective Studies; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Management of antithrombotic agents for colonoscopic polypectomies in Israeli gastroenterologists relative to published guidelines.
Topics: Aspirin; Clopidogrel; Colonic Polyps; Colonoscopy; Fibrinolytic Agents; Gastroenterology; Guideline Adherence; Health Maintenance Organizations; Heparin, Low-Molecular-Weight; Hospitals; Humans; Israel; Logistic Models; Practice Guidelines as Topic; Practice Patterns, Physicians'; Surveys and Questionnaires; Ticlopidine; Warfarin | 2013 |
Should alcohol be considered a minor protective factor for unprovoked venous thromboembolism?
Topics: Arteries; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Triple antiplatelet therapy with addition of cilostazol to aspirin and clopidogrel for Y-stent-assisted coil embolization of cerebral aneurysms.
Topics: Adult; Aged; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Tetrazoles; Ticlopidine | 2013 |
Performance assessment of microflow LC combined with high-resolution MS in bioanalysis.
Topics: Alprazolam; Biomarkers; Blood Proteins; Buspirone; Chromatography, High Pressure Liquid; Clopidogrel; Humans; Proteomics; Tandem Mass Spectrometry; Terfenadine; Ticlopidine | 2013 |
Genetic determinants of high on-treatment platelet reactivity in clopidogrel treated Chinese patients.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Asian People; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Ticlopidine | 2013 |
[Rapid aspirin desensitization in patients with a history of aspirin hypersensitivity requiring coronary angioplasty. Report of four cases].
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2013 |
Mortality after clopidogrel in the non-invasive PLATO cohort and TRILOGY ACS trial: another mismatched death paradox.
Topics: Aged; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Ticlopidine | 2013 |
Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma.
Topics: Animals; Aspirin; Blood Platelets; Carcinoma, Hepatocellular; CD8-Positive T-Lymphocytes; Cell Proliferation; Clopidogrel; Disease Models, Animal; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Mice; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Viewpoint: mismatch between the European and American guidelines on oral antiplatelet P2Y12 inhibitors after acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Clinical Trials as Topic; Clopidogrel; Europe; Evidence-Based Medicine; Guideline Adherence; Humans; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; United States | 2013 |
Differences between ACC/AHA and ESC Guidelines on antiplatelet therapy in patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials as Topic; Clopidogrel; Europe; Evidence-Based Medicine; Guideline Adherence; Humans; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine; United States | 2013 |
High on-clopidogrel treatment platelet reactivity in Thai patients with chronic stable angina scheduled for percutaneous coronary intervention.
Topics: Aged; Angina, Stable; Clopidogrel; Coronary Angiography; Coronary Restenosis; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prevalence; Prospective Studies; Risk Factors; Thailand; Ticlopidine | 2013 |
Oral anticoagulation and antiplatelets in atrial fibrillation patients after myocardial infarction and coronary intervention.
Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Denmark; Drug Therapy, Combination; Female; Humans; Incidence; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Registries; Risk Factors; Ticlopidine; Treatment Outcome | 2013 |
The impact of the environment on diseases and drugs.
Topics: Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Smoking; Thiophenes; Ticlopidine | 2013 |
Is clopidogrel adequate in 2013?
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Clopidogrel; Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
P2Y12 receptor gene polymorphism and antiplatelet effect of clopidogrel in patients with coronary artery disease after coronary stenting.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Blood Platelets; Clopidogrel; Female; Genotype; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2013 |
Risk of unfavorable long-term outcome in older adults with traumatic intracranial hemorrhage and anticoagulant or antiplatelet use.
Topics: Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Female; Glasgow Coma Scale; Humans; Injury Severity Score; Intracranial Hemorrhage, Traumatic; Male; Middle Aged; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Risk Factors; Ticlopidine; Trauma Centers; Warfarin | 2013 |
Urgent best medical therapy may obviate the need for urgent surgery in patients with symptomatic carotid stenosis.
Topics: Adult; Ambulatory Care; Carotid Stenosis; Clopidogrel; Disease Management; Drug Therapy, Combination; Endarterectomy, Carotid; Follow-Up Studies; Humans; Ischemic Attack, Transient; Referral and Consultation; Stroke; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Duplex | 2013 |
Comparative effect of clopidogrel and aspirin versus aspirin alone on laboratory parameters: a retrospective, observational, cohort study.
Topics: Aged; Aspirin; Biomarkers; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Hematologic Tests; Humans; Japan; Leukocytes; Linear Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Propensity Score; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Predictors of bleeding in acute coronary syndromes with clopidogrel and prasugrel.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Follow-Up Studies; Hemorrhage; Humans; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Ticlopidine | 2013 |
Hepatocellular toxicity of clopidogrel: mechanisms and risk factors.
Topics: Apoptosis; Cell Line; Chromatography, High Pressure Liquid; Clopidogrel; Cytochrome P-450 CYP3A; Flow Cytometry; Glutathione; Hepatocytes; Humans; Microscopy, Fluorescence; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2013 |
Safety and efficacy of ticagrelor for neuroendovascular procedures. A single center initial experience.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Cerebrovascular Disorders; Clopidogrel; Endovascular Procedures; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Retrospective Studies; Stents; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Long-term safety and efficacy of dual therapy with oral anticoagulation and clopidogrel in patients with atrial fibrillation treated with drug-eluting stents.
Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Epidemiology of CYP3A4-mediated clopidogrel drug-drug interactions and their clinical consequences.
Topics: Aged; Atorvastatin; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Platelet Aggregation Inhibitors; Pyrroles; Ticlopidine | 2013 |
Antiplatelet drugs are a risk factor for esophageal mucosal injury.
Topics: Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Aspirin; Case-Control Studies; Clopidogrel; Cytochrome P-450 CYP2C19; Esophageal Perforation; Esophageal pH Monitoring; Gastroesophageal Reflux; Genotype; Humans; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine | 2013 |
[Clopidogrel plus acetylsalicylic acid: a deadly combination].
Topics: Clopidogrel; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2013 |
Animal models of gastric bleeding induced by dual antiplatelet therapy using aspirin and clopidogrel--prophylactic effect of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Drug Synergism; Histamine H2 Antagonists; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rats; Stomach Ulcer; Ticlopidine | 2014 |
Contact- and agonist-regulated microvesiculation of human platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cell Shape; Cell-Derived Microparticles; Clopidogrel; Fibrinogen; Humans; Microscopy, Atomic Force; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Carotid artery stenting outcomes: do they correlate with antiplatelet response assays?
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Carotid Stenosis; Cerebral Revascularization; Clopidogrel; Drug Monitoring; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Prevalence; Receptors, Purinergic P2Y12; Registries; Retrospective Studies; Stents; Stroke; Ticlopidine; Treatment Outcome | 2014 |
Endovascular treatment of intracranial aneurysms with flow-diverter stents: preliminary single-centre experience.
Topics: Angiography, Digital Subtraction; Cerebral Angiography; Clopidogrel; Contrast Media; Endovascular Procedures; Female; Humans; Intracranial Aneurysm; Magnetic Resonance Angiography; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2013 |
Dual antiplatelet therapy in acute transient ischemic attack and minor stroke.
Topics: Clopidogrel; Female; Humans; Ischemic Attack, Transient; Male; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2013 |
Predictors of myocardial infarction after an acute coronary syndrome with clopidogrel and prasugrel.
Topics: Acute Coronary Syndrome; Clopidogrel; Follow-Up Studies; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Ticlopidine | 2013 |
Curcumin alters the pharmacokinetics of warfarin and clopidogrel in Wistar rats but has no effect on anticoagulation or antiplatelet aggregation.
Topics: Administration, Oral; Animals; Anticoagulants; Blood Coagulation; Chromatography, Liquid; Clopidogrel; Curcuma; Curcumin; Herb-Drug Interactions; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Wistar; Tandem Mass Spectrometry; Ticlopidine; Warfarin | 2013 |
Hidden implications: potential antiplatelet effects of adjuvant anaesthetic agents.
Topics: Adenosine Diphosphate; Adjuvants, Anesthesia; Aged; Aspirin; Cholecystectomy, Laparoscopic; Clopidogrel; Female; Hemorrhage; Humans; Intraoperative Complications; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombelastography; Ticlopidine | 2013 |
Risk of hemorrhagic complication associated with ventriculoperitoneal shunt placement in aneurysmal subarachnoid hemorrhage patients on dual antiplatelet therapy.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Female; Humans; Hydrocephalus; Intracranial Aneurysm; Intracranial Hemorrhages; Male; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Implantation; Risk; Subarachnoid Hemorrhage; Ticlopidine; Ventriculoperitoneal Shunt | 2013 |
Pharmacogenomics in cardiovascular disease: focus on aspirin and ADP receptor antagonists.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Pharmacogenetics; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2013 |
The CYP2C19*17 variant is not independently associated with clopidogrel response.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Comparison of high-resolution melting analysis, TaqMan Allelic discrimination assay, and sanger sequencing for Clopidogrel efficacy genotyping in routine molecular diagnostics.
Topics: Adult; Alleles; Clopidogrel; Female; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Multilocus Sequence Typing; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine; Treatment Outcome | 2013 |
Chasing the ACE of hearts.
Topics: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Female; Heart Diseases; Heparin, Low-Molecular-Weight; Humans; Middle Aged; Sarcoidosis; Ticlopidine; Treatment Outcome | 2013 |
Relation between the vasodilator-stimulated phosphoprotein phosphorylation assay and light transmittance aggregometry in East Asian patients after high-dose clopidogrel loading.
Topics: Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine | 2013 |
Early dual therapy for Chinese adults with TIA.
Topics: Aspirin; China; Clopidogrel; Drug Therapy, Combination; Female; Humans; Intracranial Hemorrhages; Ischemic Attack, Transient; Male; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2013 |
Comparison of clinical efficacy and safety of clopidogrel resinate with clopidogrel bisulfate in patients undergoing percutaneous coronary intervention.
Topics: Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Impact of the proton pump inhibitors and CYP2C19*2 polymorphism on platelet response to clopidogrel as assessed by four platelet function assays.
Topics: Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Function Tests; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine | 2013 |
Initial experiences with Multiplate® for rapid assessment of antiplatelet agent activity in neurosurgical emergencies.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Arachidonic Acid; Aspirin; Clopidogrel; Embolization, Therapeutic; Emergencies; Emergency Medical Services; Female; Hemostatic Techniques; Humans; Intracranial Hemorrhages; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Point-of-Care Systems; Ticlopidine | 2013 |
Multiple electrode aggregometry in antiplatelet-related intracerebral haemorrhage.
Topics: Adult; Aspirin; Blood Platelets; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2013 |
Pharmacogenomics of anti-platelet therapy focused on peripheral blood cells of coronary arterial disease patients.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Gene Expression; Gene Expression Profiling; Humans; Insulin-Like Growth Factor I; Leukocytes, Mononuclear; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Oligonucleotide Array Sequence Analysis; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, IGF Type 1; Ticlopidine; Treatment Outcome | 2013 |
Toxicity studies of a bioactive protein with antithrombotic-thrombolytic activity, DLBS1033.
Topics: Analysis of Variance; Animals; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electrophoresis, Polyacrylamide Gel; Female; Fetal Development; Fibrinolytic Agents; Mice; No-Observed-Adverse-Effect Level; Oligochaeta; Pregnancy; Rats; Rats, Wistar; Ticlopidine; Tissue Extracts; Toxicity Tests, Acute | 2014 |
Generic clopidogrel: time to substitute?
Topics: Chemistry, Pharmaceutical; Clopidogrel; Cost Savings; Drug Approval; Drug Costs; Drug Substitution; Drugs, Generic; Humans; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Therapeutic Equivalency; Ticlopidine; United States; United States Food and Drug Administration | 2013 |
Comparison of a new P2Y12 receptor specific platelet aggregation test with other laboratory methods in stroke patients on clopidogrel monotherapy.
Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Blood Platelets; Cell Adhesion Molecules; Clinical Laboratory Techniques; Clopidogrel; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Reproducibility of Results; Stroke; Ticlopidine | 2013 |
Clopidogrel effective for frequent transient monocular blindness caused by vulnerable plaque.
Topics: Angiography, Digital Subtraction; Blindness; Clopidogrel; Humans; Magnetic Resonance Angiography; Male; Middle Aged; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
Reduced clopidogrel metabolism in a multiethnic population: prevalence and rates of recurrent cerebrovascular events.
Topics: Aryl Hydrocarbon Hydroxylases; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Ethnicity; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Prevalence; Recurrence; Retrospective Studies; Stroke; Ticlopidine | 2014 |
[Relevance of CYP2C19 2 regarding platelet reactivity in patients with acute coronary syndrome treated with clopidogrel].
Topics: Acute Coronary Syndrome; Aged; Alleles; Angina, Unstable; Aryldialkylphosphatase; Biotransformation; Cardiac Catheterization; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Genotype; Hospital Mortality; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prognosis; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Stents; Stroke; Survival Analysis; Ticlopidine | 2014 |
Continuing clopidogrel during elective total hip and knee arthroplasty: assessment of bleeding risk and adverse outcomes.
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Transfusion; Clopidogrel; Elective Surgical Procedures; Female; Heart Diseases; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Ticlopidine; Treatment Outcome | 2014 |
High-dose acetylsalicylic acid is superior to low-dose as well as to clopidogrel in preventing lipopolysaccharide-induced lung injury in mice.
Topics: Acute Lung Injury; Animals; Aspirin; Blood Platelets; Bronchoalveolar Lavage Fluid; Clopidogrel; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Ticlopidine | 2013 |
Gastrointestinal adverse events after dual antiplatelet therapy: clopidogrel is safer than ticagrelor, but prasugrel data are lacking or inconclusive.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Chemical and Drug Induced Liver Injury; Clinical Trials, Phase III as Topic; Clopidogrel; Double-Blind Method; Female; Gastrointestinal Hemorrhage; Gastrointestinal Neoplasms; Humans; Kaplan-Meier Estimate; Male; Multicenter Studies as Topic; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Use and associated risks of concomitant aspirin therapy with oral anticoagulation in patients with atrial fibrillation: insights from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Cerebrovascular Disorders; Clopidogrel; Comorbidity; Dabigatran; Drug Synergism; Female; Fibrinolytic Agents; Follow-Up Studies; Hemorrhage; Hospitalization; Humans; Hypertrophy, Left Ventricular; Logistic Models; Male; Middle Aged; Models, Cardiovascular; Myocardial Ischemia; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk; Ticlopidine; Treatment Outcome | 2013 |
Erosive arthritis and hepatic granuloma formation induced by peptidoglycan polysaccharide in rats is aggravated by prasugrel treatment.
Topics: Animals; Arthritis, Experimental; Clopidogrel; Cytokines; Female; Granuloma; Inflammation; Joints; Liver; Peptidoglycan; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Rats; Rats, Inbred Lew; Thiophenes; Ticlopidine | 2013 |
Ask the doctors. I recently had a drug-eluting stent placed in one of my coronary arteries after an episode of severe chest pain. My doctor told me I had to take Plavix every day. Now I feel perfectly fine-except for my right hip. I need a hip replace
Topics: Anticoagulants; Clopidogrel; Coronary Disease; Health Behavior; Hip Fractures; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Stents; Ticlopidine; Withholding Treatment | 2013 |
[Clopidogrel resistance of patients with coronary artery disease and its correlation with platelet count and mean platelet volume].
Topics: Aged; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Mean Platelet Volume; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Ticlopidine | 2013 |
Arterial thrombosis after vehicular trauma and humeral fracture in a dog.
Topics: Accidents, Traffic; Animals; Anticoagulants; Clopidogrel; Dalteparin; Dog Diseases; Dogs; Female; Forelimb; Fracture Fixation, Internal; Fractures, Bone; Heparin; Thrombosis; Ticlopidine | 2013 |
P2Y12 Receptor Blockade and Myocardial Perfusion.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Coronary Vessels; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2013 |
The place of newer oral anticoagulants in the treatment of patients with non-valvular atrial fibrillation and coronary artery disease.
Topics: Administration, Oral; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine | 2013 |
Personalised antiplatelet therapy: are we ready for prime time? Data from China.
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Drug-Eluting Stents; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2013 |
Clinical assessment, platelet reactivity measurement or genetic testing after acute coronary syndrome? What benefits the patient?
Topics: Acute Coronary Syndrome; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Drug-Eluting Stents; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2013 |
The impact of gene polymorphism and high on-treatment platelet reactivity on clinical follow-up: outcomes in patients with acute coronary syndrome after drug-eluting stent implantation.
Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Ischemia; China; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Resistance; Drug-Eluting Stents; Female; Genotype; Hemorrhage; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prospective Studies; Receptors, Purinergic P2Y12; Risk Factors; ROC Curve; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
The effect of antiplatelet and anticoagulant therapy on the clinical outcome of patients undergoing ureteroscopy.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Female; Humans; Lithotripsy, Laser; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome; Ureteroscopy; Urolithiasis; Warfarin | 2013 |
Long-term effect of dual antiplatelet treatment after off-pump coronary artery bypass grafting.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Coronary Artery Bypass, Off-Pump; Drug Therapy, Combination; Endpoint Determination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multivariate Analysis; Patient Readmission; Platelet Aggregation Inhibitors; Postoperative Complications; Prognosis; Retrospective Studies; Ticlopidine; Time Factors | 2013 |
Use of clopidogrel and proton pump inhibitors after a serious acute coronary event: risk of coronary events and peptic ulcer bleeding.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Cohort Studies; Coronary Vessels; Drug Interactions; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Peptic Ulcer Hemorrhage; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Risk; Ticlopidine; United Kingdom | 2013 |
Why have studies of tailored anti-platelet therapy failed so far?
Topics: Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Humans; Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Precision Medicine; Randomized Controlled Trials as Topic; Research Design; Ticlopidine; Treatment Failure | 2013 |
Platelet reactivity in the early and late phases of acute coronary syndromes according to cytochrome P450 2C19 phenotypes.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Alleles; Aryl Hydrocarbon Hydroxylases; Asian People; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Stents; Ticlopidine | 2013 |
Inhibition of platelet activation by clopidogrel prevents hypertension-induced cardiac inflammation and fibrosis.
Topics: Angiotensin II; Animals; Clopidogrel; Fibrosis; Hypertension; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Myocarditis; Myocardium; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Transforming Growth Factor beta | 2013 |
DES thrombosis related to antiplatelet therapy noncompliance: a consequence of the Greek financial crisis.
Topics: Aged, 80 and over; Clopidogrel; Drug-Eluting Stents; Economic Recession; Greece; Humans; Male; Medication Adherence; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2013 |
Cost-effectiveness of 12-month treatment with ticagrelor compared with clopidogrel in the management of acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Australia; Clopidogrel; Coronary Artery Bypass; Cost-Benefit Analysis; Drug Costs; Hemorrhage; Humans; Markov Chains; Middle Aged; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Racial disparity with on-treatment platelet reactivity in patients undergoing percutaneous coronary intervention.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Black or African American; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Logistic Models; Male; Middle Aged; Mutation; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Ticlopidine | 2013 |
[The ARCTIC study].
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug-Eluting Stents; Heart Diseases; Humans; Myocardial Ischemia; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine | 2013 |
[The WOEST study].
Topics: Aspirin; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Randomized Controlled Trials as Topic; Ticlopidine | 2013 |
Prevalence of nonresponsiveness to aspirin in patients with symptomatic peripheral arterial disease using true point of care testing.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Peripheral Vascular Diseases; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Risk Factors; Ticlopidine | 2014 |
My patient had a small vessel stroke, are two antiplatelet agents better than one?
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke, Lacunar; Ticlopidine | 2013 |
Clopidogrel is safer than ticagrelor in regard to bleeds: a closer look at the PLATO trial.
Topics: Adenosine; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Hemorrhage; Humans; Incidence; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2013 |
Clinical applications of pharmacogenetics: present and near future.
Topics: Anticoagulants; Cardiovascular Diseases; Clopidogrel; Genetic Testing; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine; Warfarin | 2013 |
Isolated foot drop in acute infarction of the supplementary motor area.
Topics: Brain Ischemia; Cerebral Angiography; Cerebral Infarction; Clopidogrel; Diffusion Magnetic Resonance Imaging; Female; Foot; Humans; Hyperlipidemias; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Middle Aged; Motor Cortex; Neural Conduction; Neurologic Examination; Neuromuscular Diseases; Oxygen; Platelet Aggregation Inhibitors; Ticlopidine; Tomography, X-Ray Computed; Vertigo | 2013 |
Provision of gastroprotective medication and bleeding risk following acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2013 |
Effectiveness of switching 'hyper responders' from Prasugrel to Clopidogrel after acute coronary syndrome: the POBA (Predictor of Bleeding with Antiplatelet drugs) SWITCH study.
Topics: Acute Coronary Syndrome; Clopidogrel; Drug Substitution; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
[Relationship between human platelet antigen-1 gene polymorphism and clopidogrel resistance in patients with coronary artery disease].
Topics: Antigens, Human Platelet; Blood Platelets; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Genetic Predisposition to Disease; Humans; Integrin beta3; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2013 |
Optimal anticoagulation during off pump coronary artery bypass in patients recently exposed to clopidogrel.
Topics: Age Factors; Aged; Anastomosis, Surgical; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Heparin; Humans; Intraoperative Complications; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Perioperative Period; Platelet Aggregation Inhibitors; Premedication; Reference Values; Retrospective Studies; Sex Factors; Ticlopidine; Whole Blood Coagulation Time | 2013 |
Characterization of the aggregation responses of camel platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Camelus; Clopidogrel; Collagen; Epinephrine; Female; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2; Ticlopidine | 2013 |
Plasma and whole blood clot strength measured by thrombelastography in patients treated with clopidogrel during acute coronary syndromes.
Topics: Acute Coronary Syndrome; C-Reactive Protein; Clopidogrel; Female; Fibrinogen; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombelastography; Ticlopidine | 2013 |
Sequential value-of-information assessment for prospective drug safety monitoring using claims databases: the comparative safety of prasugrel v. clopidogrel.
Topics: Clopidogrel; Drug Monitoring; Humans; Insurance Claim Review; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Thiophenes; Ticlopidine | 2013 |
Use of buddy wire to facilitate Y-configured stent placement in middle cerebral artery bifurcation aneurysms with daughter branches arising from the sac: a technical note.
Topics: Angiography, Digital Subtraction; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Humans; Imaging, Three-Dimensional; Intracranial Aneurysm; Magnetic Resonance Imaging; Male; Middle Aged; Middle Cerebral Artery; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2014 |
Impact of the CYP2C19*17 polymorphism on the clinical outcome of clopidogrel therapy in Asian patients undergoing percutaneous coronary intervention.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Genetic Linkage; Genetic Variation; Genotype; Hemorrhage; Humans; Myocardial Infarction; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2013 |
Effects of endothelial dysfunction on residual platelet aggregability after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Endothelium, Vascular; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Ticlopidine | 2013 |
Five years on dual-antiplatelet therapy. DES thrombosis after clopidogrel withdrawal.
Topics: Aged; Antineoplastic Agents, Phytogenic; Clopidogrel; Drug-Eluting Stents; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Paclitaxel; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Time Factors; Ultrasonography, Interventional; Withholding Treatment | 2013 |
Identification of poor response to P2Y12 inhibitors in ACS patients with a new ELISA-based vasodilator-associated stimulated phosphoprotein (VASP) phosphorylation assay.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Cell Adhesion Molecules; Cell Separation; Clopidogrel; Enzyme-Linked Immunosorbent Assay; Feasibility Studies; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Piperazines; Platelet Function Tests; Prasugrel Hydrochloride; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Thiophenes; Ticlopidine | 2013 |
Microglial P2Y12 deficiency/inhibition protects against brain ischemia.
Topics: Animals; Apoptosis; Astrocytes; Brain Ischemia; CA1 Region, Hippocampal; Cell Hypoxia; Cell Movement; Cell Survival; Cells, Cultured; Clopidogrel; Coculture Techniques; Gene Knockdown Techniques; Glucose; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neurons; NF-kappa B; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2013 |
P2RY12 gene polymorphisms and effect of clopidogrel on platelet aggregation.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y12; Ticlopidine | 2013 |
Pro-inflammatory role of platelets in hypertension-mediated end-organ damage : Editorial to: "Inhibition of Platelet activation by clopidogrel prevents hypertension-induced cardiac inflammation and fibrosis" by L.-X. Jia et al.
Topics: Animals; Clopidogrel; Fibrosis; Hypertension; Male; Myocarditis; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2013 |
Antiplatelet and anticoagulation therapy in microlaryngeal surgery.
Topics: Adult; Aged; Aspirin; Clopidogrel; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Incidence; Laryngeal Diseases; Laryngectomy; Laryngoplasty; Male; Microsurgery; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Period; Retrospective Studies; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome; United States | 2014 |
Risks and benefits of early antithrombotic therapy after thrombolytic treatment in patients with acute stroke.
Topics: Administration, Oral; Aged; Aspirin; Brain; Clopidogrel; Female; Fibrinolytic Agents; Heparin; Humans; Injections, Intravenous; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Secondary Prevention; Stroke; Thrombolytic Therapy; Ticlopidine | 2013 |
Clopidogrel reduces post-transplant obliterative bronchiolitis.
Topics: Animals; Blood Platelets; Bronchiolitis Obliterans; Calcineurin Inhibitors; Clopidogrel; Cytokines; Everolimus; Gene Expression Regulation; Immunohistochemistry; Isoantibodies; Lung Diseases; Lung Transplantation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microscopy, Fluorescence; Models, Animal; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Sirolimus; T-Lymphocytes; Tacrolimus; Ticlopidine; Time Factors; TOR Serine-Threonine Kinases; Trachea | 2013 |
A comparative study of bivalirudin plus clopidogrel versus bivalirudin plus prasugrel in primary angioplasty using propensity score matching.
Topics: Angioplasty; Antithrombins; Clopidogrel; Cohort Studies; Drug Combinations; Female; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Piperazines; Postoperative Complications; Prasugrel Hydrochloride; Recombinant Proteins; Retrospective Studies; Thiophenes; Thrombosis; Ticlopidine | 2013 |
The safety of thoracentesis in patients with uncorrected bleeding risk.
Topics: Aged; Aged, 80 and over; Anticoagulants; Blood Coagulation Disorders; Clopidogrel; Cohort Studies; Drainage; Female; Hepatic Insufficiency; Humans; International Normalized Ratio; Male; Middle Aged; Platelet Aggregation Inhibitors; Pleural Effusion; Postoperative Hemorrhage; Prospective Studies; Renal Insufficiency, Chronic; Risk Factors; Thrombocytopenia; Ticlopidine; Warfarin | 2013 |
TRILOGY ACS: prasugrel of benefit only after angiography?
Topics: Angina, Unstable; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2013 |
Platelet activity measured by a rapid turnaround assay identifies coronary artery bypass grafting patients at increased risk for bleeding and transfusion complications after clopidogrel administration.
Topics: Aged; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Artery Bypass; Decision Support Techniques; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Patient Selection; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Hemorrhage; Predictive Value of Tests; Preoperative Care; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Transfusion Reaction; Treatment Outcome | 2013 |
Pharmacodynamic effect of clopidogrel in patients undergoing transcatheter aortic valve implantation.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aortic Valve; Blood Platelets; Blood Vessel Prosthesis; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Myocardial Infarction; Platelet Activation; Ticlopidine | 2013 |
Acute myocardial infarction in pregnancy following unlicensed use of methylenedioxymethamphetamine ('Ecstasy').
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic Uptake Inhibitors; Adult; Aspirin; Bisoprolol; Chest Pain; Clopidogrel; Female; Humans; Infant, Newborn; Male; Myocardial Infarction; N-Methyl-3,4-methylenedioxyamphetamine; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Ticlopidine | 2013 |
Influence of genetic variations on levels of inflammatory markers of healthy subjects at baseline and one week after clopidogrel therapy; results of a preliminary study.
Topics: Adult; Anti-Inflammatory Agents; Aryl Hydrocarbon Hydroxylases; C-Reactive Protein; CD40 Antigens; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Association Studies; Haptoglobins; Humans; Inflammation Mediators; Male; Orosomucoid; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Ticlopidine; Young Adult | 2013 |
Clinical implications of very low on-treatment platelet reactivity in patients treated with thienopyridine: the POBA study (predictor of bleedings with antiplatelet drugs).
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Area Under Curve; Biomarkers; Cell Adhesion Molecules; Clopidogrel; Coronary Thrombosis; Drug Resistance; Female; Hemorrhage; Humans; Logistic Models; Male; Microfilament Proteins; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Phosphoproteins; Phosphorylation; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Risk Assessment; Risk Factors; ROC Curve; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Bleeding and thrombosis risk matters: how long can we stick to the one-size-fits-all strategy of platelet inhibition?
Topics: Acute Coronary Syndrome; Clopidogrel; Female; Hemorrhage; Humans; Male; Percutaneous Coronary Intervention; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2013 |
Defining predictive values using three different platelet function tests for CYP2C19 phenotype status on maintenance dual antiplatelet therapy after PCI.
Topics: Alleles; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Genotype; Humans; Myocardial Ischemia; Percutaneous Coronary Intervention; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; ROC Curve; Ticlopidine | 2014 |
Predictive values of post-clopidogrel platelet reactivity assessed by different platelet function tests on ischemic events in East Asian patients treated with PCI.
Topics: Aged; Asian People; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Republic of Korea; Risk Factors; ROC Curve; Ticlopidine | 2014 |
Effect of antiplatelet therapy on thromboembolism after flow diversion with the pipeline embolization device.
Topics: Adolescent; Adult; Aged; Anticoagulants; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Diffusion Magnetic Resonance Imaging; Embolization, Therapeutic; Female; Heparin; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Stents; Thromboembolism; Ticlopidine; Treatment Outcome; Young Adult | 2013 |
PlaCor PRT measurement of shear-activated platelet aggregate formation in stable patients treated with single and dual antiplatelet therapy.
Topics: Aspirin; Blood Platelets; Blood Specimen Collection; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Shear Strength; Ticlopidine | 2014 |
Variability of on-treatment platelet reactivity in patients on clopidogrel.
Topics: Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Quality of Life; Ticlopidine | 2014 |
Antiplatelet effect of thienopyridine (clopidogrel or prasugrel) pretreatment in patients undergoing primary percutaneous intervention for ST elevation myocardial infarction.
Topics: Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Pyridines; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Efficacy and safety of aspirin, clopidogrel, and warfarin after coronary artery stenting in Korean patients with atrial fibrillation.
Topics: Aged; Anticoagulants; Asian People; Aspirin; Atrial Fibrillation; Blood Coagulation; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Disease-Free Survival; Drug Monitoring; Drug Therapy, Combination; Female; Hemorrhage; Humans; International Normalized Ratio; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Republic of Korea; Retrospective Studies; Risk Factors; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2014 |
PON1 Q192R genotype influences clopidogrel responsiveness by relative platelet inhibition instead of on-treatment platelet reactivity.
Topics: Angina, Unstable; Aryl Hydrocarbon Hydroxylases; Aryldialkylphosphatase; Blood Platelets; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2013 |
[The staged treatment of popliteal, ileal and femoral arteries aneurisms].
Topics: Aneurysm; Clopidogrel; Combined Modality Therapy; Femoral Artery; Humans; Iliac Artery; Male; Middle Aged; Platelet Aggregation Inhibitors; Popliteal Artery; Popliteal Vein; Pulmonary Embolism; Ticlopidine; Tomography, Spiral Computed; Treatment Outcome; Ultrasonography, Doppler; Vascular Grafting | 2013 |
The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection.
Topics: Adenoma; Aged; Anti-Ulcer Agents; Anticoagulants; Aspirin; Carcinoma; Case-Control Studies; Clopidogrel; Dissection; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Stomach Diseases; Stomach Neoplasms; Stomach Ulcer; Thienopyridines; Ticlopidine; Warfarin | 2013 |
An allele-specific PCR system for rapid detection and discrimination of the CYP2C19∗4A, ∗4B, and ∗17 alleles: implications for clopidogrel response testing.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Base Sequence; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Genetic Association Studies; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Prodrugs; Reference Standards; Sensitivity and Specificity; Sequence Analysis, DNA; Ticlopidine | 2013 |
Withholding clopidogrel for 3 to 6 versus 7 days or more before surgery in hip fracture patients.
Topics: Aged; Aged, 80 and over; Blood Loss, Surgical; Clopidogrel; Female; Hemorrhage; Hip Fractures; Humans; Male; Middle Aged; Orthopedic Procedures; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors; Withholding Treatment | 2013 |
Effects of clopidogrel on mortality, cardiovascular and bleeding outcomes in patients with chronic kidney disease - data from Taiwan acute coronary syndrome full spectrum registry.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Registries; Renal Insufficiency, Chronic; Taiwan; Ticlopidine; Treatment Outcome | 2013 |
Indirect estimation of the comparative treatment effect in pharmacogenomic subgroups.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Genetic Association Studies; Humans; Models, Statistical; Pharmacogenetics; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2013 |
Red cell-derived microparticles (RMP) as haemostatic agent.
Topics: Adenosine Diphosphate; Animals; Bleeding Time; Blood Coagulation Disorders; Busulfan; Cell Separation; Cell-Derived Microparticles; Clopidogrel; Disease Models, Animal; Erythrocytes; Flow Cytometry; Hemostasis; Humans; Male; Platelet Aggregation; Rabbits; Rats; Rats, Sprague-Dawley; Thrombelastography; Thrombin; Thrombocytopenia; Thromboplastin; Ticlopidine | 2013 |
Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel.
Topics: Acetates; Animals; Clopidogrel; Esterases; Humans; Hydrolysis; Intestinal Mucosa; Microsomes; Phenylacetates; Prodrugs; Rats; Rats, Sprague-Dawley; Thiophenes; Ticlopidine | 2014 |
Stratified reporting of high sensitivity troponin I assay is associated with suboptimal management of patients with acute coronary syndrome and intermediate troponin elevation.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Clopidogrel; Cohort Studies; Coronary Angiography; Female; Humans; Male; Myocardial Infarction; Retrospective Studies; Risk; Ticlopidine; Troponin I; Withholding Treatment | 2013 |
Cost-effectiveness of different strategies for stroke prevention in patients with atrial fibrillation in a health resource-limited setting.
Topics: Anticoagulants; Aspirin; Atrial Fibrillation; China; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Humans; Models, Economic; Morpholines; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Risk Factors; Rivaroxaban; Stroke; Thiophenes; Ticlopidine; Warfarin | 2014 |
Cilostazol--a forgotten antiplatelet agent, but does it even matter?
Topics: Cilostazol; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine | 2013 |
Increased endoplasmic reticulum stress response is involved in clopidogrel-induced apoptosis of gastric epithelial cells.
Topics: Apoptosis; Cell Line; Cell Proliferation; Clopidogrel; Cluster Analysis; Down-Regulation; Endoplasmic Reticulum Stress; Epithelial Cells; Gene Expression Profiling; Humans; Imidazoles; Molecular Sequence Annotation; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Stomach; Ticlopidine; Up-Regulation | 2013 |
Comparison of the degree of platelet aggregation inhibition with prasugrel versus clopidogrel and clinical outcomes in patients with unprotected left main disease treated with everolimus-eluting stents.
Topics: Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Everolimus; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Sirolimus; Thiophenes; Ticlopidine; Treatment Outcome | 2013 |
Expert position paper on the role of platelet function testing in patients undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Substitution; Drug Therapy, Combination; Genotype; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Activation; Platelet Function Tests; Practice Guidelines as Topic; Prognosis; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticlopidine | 2014 |
Impact of initial clinical presentation on clopidogrel low response.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Female; Humans; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Factors influencing multiplate whole blood impedance platelet aggregometry measurements, during aspirin treatment in acute ischemic stroke: a pilot study.
Topics: Adult; Aged; Aspirin; Blood Platelets; Brain Ischemia; C-Reactive Protein; Cholesterol, HDL; Clopidogrel; Electric Impedance; Female; Fibrinogen; Glycated Hemoglobin; Humans; Leukocyte Count; Leukocytes; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Thromboxane B2; Ticlopidine; von Willebrand Factor | 2013 |
Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study.
Topics: Aged; Aged, 80 and over; Cerebral Hemorrhage; Clopidogrel; Cross-Sectional Studies; Female; Humans; Male; Microvessels; Middle Aged; Platelet Aggregation Inhibitors; Prevalence; Prospective Studies; Stroke; Ticlopidine | 2013 |
Predictors of 1-year outcomes in the Taiwan Acute Coronary Syndrome Full Spectrum Registry.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Patient Discharge; Platelet Aggregation Inhibitors; Prognosis; Registries; Stroke; Taiwan; Ticlopidine; Treatment Outcome | 2014 |
Endoscopic biopsy on patients taking antiplatelet agents: how much do we follow BSG, ASGE or ESGE guidelines?
Topics: Aspirin; Biopsy; Clopidogrel; Endoscopy, Gastrointestinal; Gastrointestinal Hemorrhage; Humans; Physicians; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Professional Practice; Risk; Surveys and Questionnaires; Ticlopidine | 2014 |
[Informativeness of genetic factors for optimization of personalized therapy with clopidogrel].
Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Siberia; Ticlopidine | 2013 |
Pharmacogenetics of neural injury recovery.
Topics: Anticoagulants; Brain Injuries; Clopidogrel; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Recovery of Function; Stroke; Ticlopidine; Warfarin | 2013 |
Novel uses for platelet function testing in the clinical laboratory: where are we now?
Topics: Aspirin; Blood Coagulation Tests; Clopidogrel; Drug Monitoring; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Randomized Controlled Trials as Topic; Risk; Ticlopidine | 2014 |
Cilostazol-based triple antiplatelet therapy in the era of generic clopidogrel and new potent antiplatelet agents.
Topics: Aspirin; Cilostazol; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine | 2014 |
Sex differences in spontaneous reports on adverse bleeding events of antithrombotic treatment.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aspirin; Child; Child, Preschool; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Female; Fibrinolytic Agents; Hemorrhage; Humans; Infant; Infant, Newborn; Male; Middle Aged; Practice Patterns, Physicians'; Risk; Sex Factors; Sweden; Ticlopidine; Warfarin; Young Adult | 2014 |
Risk factors of gastrointestinal bleeding in clopidogrel users: a nationwide population-based study.
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Cohort Studies; Databases, Factual; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proportional Hazards Models; Regression Analysis; Renal Insufficiency, Chronic; Risk Factors; Selective Serotonin Reuptake Inhibitors; Taiwan; Ticlopidine | 2013 |
Hemorrhagic complications of thoracentesis and small-bore chest tube placement in patients taking clopidogrel.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Chest Tubes; Clopidogrel; Cohort Studies; Female; Hemothorax; Humans; Male; Middle Aged; Paracentesis; Platelet Aggregation Inhibitors; Pleural Effusion; Prospective Studies; Ticlopidine; Ultrasonography, Interventional | 2014 |
Diagnoses of gastrointestinal cancers after gastrointestinal bleeding in patients receiving clopidogrel or warfarin.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Cohort Studies; Female; Gastrointestinal Hemorrhage; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Ticlopidine; Time Factors; Warfarin; Young Adult | 2013 |
Simple catalytic mechanism for the direct coupling of α-carbonyls with functionalized amines: a one-step synthesis of Plavix.
Topics: Aldehydes; Amines; Bromides; Catalysis; Clopidogrel; Copper; Diethylpropion; Esters; Ticlopidine | 2013 |
Hematocrit alters VerifyNow P2Y12 assay results independently of intrinsic platelet reactivity and clopidogrel responsiveness.
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Clopidogrel; Female; Hematocrit; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2013 |
Risk of intracranial injury after minor head trauma in patients with pre-injury use of clopidogrel.
Topics: Adult; Case-Control Studies; Clopidogrel; Craniocerebral Trauma; Female; Humans; Intracranial Hemorrhage, Traumatic; Male; Middle Aged; Neuroimaging; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Tomography, X-Ray Computed | 2014 |
Misrepresentation of vital status follow-up: challenging the integrity of the PLATO trial and the claimed mortality benefit of ticagrelor versus clopidogrel.
Topics: Adenosine; Advisory Committees; Clinical Trials as Topic; Clopidogrel; Contraindications; Drug Approval; Follow-Up Studies; Humans; Mortality; Purinergic P2Y Receptor Antagonists; Risk Assessment; Ticagrelor; Ticlopidine; Treatment Outcome; Vital Statistics | 2013 |
[ASA and clopidogrel for urological operations. Perioperative management].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine; Urologic Surgical Procedures | 2013 |
[The CHAMPION PHOENIX study].
Topics: Adenosine Monophosphate; Clopidogrel; Coronary Restenosis; Coronary Stenosis; Coronary Thrombosis; Double-Blind Method; Hemorrhage; Humans; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Revascularization; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Stents; Ticlopidine | 2013 |
[Primary angioplasty in a patient with acute inferior myocardial infarction: the unexpected trap].
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aortography; Aspirin; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Coronary Vessel Anomalies; Electrocardiography; Female; Humans; Lysine; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Radial Artery; Stents; Ticlopidine; Tomography, X-Ray Computed | 2013 |
Duration of dual antiplatelet treatment with clopidogrel and aspirin in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Hospitalization; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Risk Factors; Stents; Stroke; Ticlopidine; Treatment Outcome | 2014 |
Effects of ex vivo platelet supplementation on platelet aggregability in blood samples from patients treated with acetylsalicylic acid, clopidogrel, or ticagrelor.
Topics: Adenosine; Adenosine Diphosphate; Aged; Arachidonic Acid; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Transfusion; Ticagrelor; Ticlopidine | 2014 |
Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy.
Topics: Adolescent; Anticoagulants; Antiphospholipid Syndrome; Chemical and Drug Induced Liver Injury; Clopidogrel; Drug Substitution; Drug Therapy, Combination; Female; Flank Pain; Hemorrhage; Humans; Hydroxychloroquine; International Normalized Ratio; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Scalp; Skin Diseases; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Venous Thrombosis | 2013 |
Clopidogrel results in favourable changes in nitric oxide metabolism in patients undergoing percutaneous coronary intervention.
Topics: Biomarkers; Clopidogrel; Coronary Artery Disease; Cyclic GMP; Humans; Nitrates; Nitric Oxide; Nitrites; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Time Factors; Treatment Outcome; Vasodilation; Wales | 2014 |
Efficacy of contemporary medical management for asymptomatic carotid artery stenosis.
Topics: Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogrel; Databases, Factual; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Stroke; Ticlopidine; Treatment Outcome; Warfarin | 2013 |
Percutaneous dilational tracheostomy in patients receiving antiplatelet therapy: is it safe?
Topics: Aged; Blood Loss, Surgical; Case-Control Studies; Clopidogrel; Dilatation; Erythrocyte Indices; Female; Humans; Male; Middle Aged; Patient Safety; Platelet Aggregation Inhibitors; Preoperative Care; Retrospective Studies; Ticlopidine; Tracheostomy | 2013 |
Pharmacogenetics and its relevance to clinical practice.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Camptothecin; Carbamazepine; Clopidogrel; Cytochrome P-450 CYP2C19; Glucuronosyltransferase; HLA-A Antigens; HLA-B Antigens; Humans; Irinotecan; Platelet Aggregation Inhibitors; Stevens-Johnson Syndrome; Ticlopidine; Topoisomerase I Inhibitors | 2013 |
Value of high-sensitivity troponin in assessing the extent of benefit provided by ticagrelor versus clopidogrel in non-ST-segment elevation acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Myocardial Revascularization; Ticagrelor; Ticlopidine | 2014 |
Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.
Topics: Adult; Aryldialkylphosphatase; Carboxylesterase; Carboxylic Ester Hydrolases; Clopidogrel; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Esterases; Humans; Male; Microsomes; Microsomes, Liver; NADP; Platelet Aggregation Inhibitors; Protein Isoforms; Sulfhydryl Compounds; Ticlopidine; Young Adult | 2014 |
Third generation P2Y12 antagonists inhibit platelet aggregation more effectively than clopidogrel in a myocardial infarction registry.
Topics: Adenosine; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Drug Design; Female; Germany; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Antiplatelet resistance in outpatients with monitored adherence.
Topics: Aged; Aspirin; Clopidogrel; Cross-Sectional Studies; Drug Interactions; Drug Resistance; Female; Humans; Male; Medication Adherence; Outpatients; Platelet Aggregation Inhibitors; Surveys and Questionnaires; Ticlopidine | 2014 |
Changes in response to antiaggregatory treatment in patients with myeloproliferative neoplasms: a sequential study using multiple electrode aggregometry.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Electrodes; Female; Hematologic Neoplasms; Humans; Male; Middle Aged; Myeloproliferative Disorders; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Thrombosis; Ticlopidine; Treatment Outcome | 2013 |
Impact of obesity and the metabolic syndrome on response to clopidogrel or prasugrel and bleeding risk in patients treated after coronary stenting.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Humans; Incidence; Male; Metabolic Syndrome; Middle Aged; Obesity; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Stents; Thiophenes; Ticlopidine; United States | 2014 |
Anti-platelet activity of a three-finger toxin (3FTx) from Indian monocled cobra (Naja kaouthia) venom.
Topics: Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Cells, Cultured; Clopidogrel; Elapid Venoms; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Thrombin; Ticlopidine | 2013 |
[Polymorphs of clopidogrel bisulfate].
Topics: Calorimetry, Differential Scanning; Clopidogrel; Crystallization; Evaluation Studies as Topic; Platelet Aggregation Inhibitors; Spectroscopy, Fourier Transform Infrared; Ticlopidine; X-Ray Diffraction | 2013 |
Impact of CYP2C19 genetic testing on provider prescribing patterns for antiplatelet therapy after acute coronary syndromes and percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Substitution; Female; Genetic Testing; Genotype; Health Personnel; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenetics; Piperazines; Platelet Aggregation Inhibitors; Postoperative Complications; Practice Patterns, Physicians'; Prasugrel Hydrochloride; Sequence Deletion; Thiophenes; Ticlopidine | 2013 |
Discontinuation of secondary prevention medication after myocardial infarction - the role of general practitioners and patients.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Female; General Practice; Guideline Adherence; Humans; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Secondary Prevention; Surveys and Questionnaires; Ticlopidine | 2013 |
[What is the benefits of statin and clopidogrel pretreatment before carotid stent implantation].
Topics: Blood Vessel Prosthesis Implantation; Carotid Arteries; Clopidogrel; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2013 |
Impact of -455G/a polymorphism of the β-fibrinogen gene on platelet aggregation in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Female; Fibrinogen; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Assessment; Ticlopidine | 2014 |
US lawyers investigate trial that secured license for AstraZeneca's antiplatelet drug.
Topics: Adenosine; Clopidogrel; Consumer Product Safety; Drug Approval; Drug Industry; Drug Therapy, Combination; Female; Humans; Licensure; Male; Public Health; Purinergic P2Y Receptor Antagonists; Risk Assessment; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2013 |
Monitoring persistent platelet reactivity in patients with unprotected left main stenting.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine | 2013 |
Predictors, cost, and outcomes of patients with acute coronary syndrome who receive optimal secondary prevention therapy: results from the antiplatelet treatment observational registries (APTOR).
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Europe; Female; Health Care Costs; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Quality of Life; Registries; Secondary Prevention; Stents; Ticlopidine; Treatment Outcome | 2013 |
Platelet inhibition by adjunctive cilostazol suppresses the frequency of cerebral ischemic lesions after carotid artery stenting in patients with carotid artery stenosis.
Topics: Aged; Angioplasty; Aspirin; Brain Ischemia; Carotid Stenosis; Cilostazol; Clopidogrel; Diffusion Magnetic Resonance Imaging; Drug Resistance; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Stents; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Drug interactions with good old clopidogrel: case closed.
Topics: Acute Coronary Syndrome; Calcium Channel Blockers; Clopidogrel; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Percutaneous Coronary Intervention; Piperazines; Prasugrel Hydrochloride; Thiophenes; Ticlopidine | 2013 |
Extending the indications of flow diversion to small, unruptured, saccular aneurysms of the anterior circulation.
Topics: Aged; Cerebral Angiography; Cerebrovascular Circulation; Clopidogrel; Databases, Factual; Embolization, Therapeutic; Endovascular Procedures; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2014 |
'VASPFix' for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists.
Topics: Adenosine; Adenosine Diphosphate; Alprostadil; Biomarkers, Pharmacological; Blood Platelets; Bucladesine; Cell Adhesion Molecules; Cells, Cultured; Clopidogrel; Cyclic AMP; Humans; Iloprost; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Reproducibility of Results; Sensitivity and Specificity; Thiophenes; Thrombophilia; Ticlopidine | 2014 |
Bleeding outcomes in patients given clopidogrel within 5 days of robotic coronary artery bypass graft procedure.
Topics: Academic Medical Centers; Aged; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Robotics; Tertiary Care Centers; Ticlopidine | 2014 |
Routine assessment of on-clopidogrel platelet reactivity and gene polymorphisms in predicting clinical outcome following drug-eluting stent implantation in patients with stable coronary artery disease.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Biotransformation; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Decision Support Techniques; Drug Therapy, Combination; Drug-Eluting Stents; Female; Genotype; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Patient Selection; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Predictive Value of Tests; Proportional Hazards Models; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2013 |
Platelet and leukocyte ROS production and lipoperoxidation are associated with high platelet reactivity in Non-ST elevation myocardial infarction (NSTEMI) patients on dual antiplatelet treatment.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cell Separation; Clopidogrel; Drug Administration Schedule; Female; Flow Cytometry; Humans; Leukocytes; Lipid Peroxidation; Male; Middle Aged; Myocardial Infarction; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Reactive Oxygen Species; Ticlopidine | 2013 |
Clustering of acute and subacute stent thrombosis related to the introduction of generic clopidogrel.
Topics: Acute Disease; Aged; Aged, 80 and over; Clopidogrel; Cluster Analysis; Drug Substitution; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stents; Thrombosis; Ticlopidine | 2014 |
Ticlopidine and clopidogrel, sometimes combined with aspirin, only minimally increase the surgical risk in renal transplantation: a case-control study.
Topics: Aspirin; Blood Loss, Surgical; Case-Control Studies; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Graft Survival; Humans; Incidence; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Prognosis; Retrospective Studies; Risk; Risk Factors; Survival Rate; Ticlopidine; Time Factors | 2014 |
The enigmatic search for optimal DAPT duration.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Cost-effectiveness of using CYP2C19 genotype to guide selection of clopidogrel or ticagrelor in Australia.
Topics: Acute Coronary Syndrome; Adenosine; Alleles; Aryl Hydrocarbon Hydroxylases; Australia; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Genotype; Humans; Markov Chains; Ticagrelor; Ticlopidine | 2013 |
Disbalance between mortality and non-fatal vascular events in the CHAMPION-PHOENIX trial: the cangrelor efficacy challenge.
Topics: Adenosine Monophosphate; Blood Platelets; Clopidogrel; Data Interpretation, Statistical; Humans; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Randomized Controlled Trials as Topic; Research Design; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Clopidogrel cessation triggers aspirin rebound in patients with coronary stent.
Topics: Aspirin; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Substance Withdrawal Syndrome; Ticlopidine | 2014 |
Sex differences in the treatment and outcome of patients with acute coronary syndrome after percutaneous coronary intervention: a population-based study.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Female; Humans; Insurance, Health; Male; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Population Surveillance; Propensity Score; Regression Analysis; Retrospective Studies; Sex Factors; Taiwan; Ticlopidine; Treatment Outcome | 2014 |
Spontaneous chest wall hematoma with dual antiplatelet therapy.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Follow-Up Studies; Hematoma; Humans; Male; Platelet Aggregation Inhibitors; Thoracic Wall; Ticlopidine; Tomography, X-Ray Computed | 2014 |
Acquired pure red cell aplasia due to treatment with clopidogrel: first case report.
Topics: Clopidogrel; Coronary Disease; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Humans; Hyperlipidemias; Hypertension; Middle Aged; Platelet Aggregation Inhibitors; Red-Cell Aplasia, Pure; Ticlopidine | 2014 |
Japanese postmarketing surveillance of clopidogrel for patients with non-ST-segment-elevation acute coronary syndrome indicated for percutaneous coronary intervention (J-PLACE NSTE-ACS).
Topics: Acute Coronary Syndrome; Adult; Aged; Clopidogrel; Female; Follow-Up Studies; Humans; Japan; Kaplan-Meier Estimate; Male; Middle Aged; Patient Safety; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Risk Factors; Ticlopidine | 2014 |
Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence.
Topics: Acrylamides; Animals; Blood Platelets; Clopidogrel; Dinoprostone; Disease Models, Animal; Mice; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Prostaglandin E, EP3 Subtype; Sulfones; Thrombosis; Ticlopidine | 2014 |
Thrombotic aortic restenosis after transapical SAPIEN valve implantation.
Topics: Aged, 80 and over; Anticoagulants; Aortic Valve Stenosis; Aspirin; Bioprosthesis; Clopidogrel; Echocardiography, Transesophageal; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Heparin; Humans; Male; Prosthesis Failure; Recurrence; Thrombosis; Ticlopidine; Treatment Outcome | 2014 |
In-hospital switching of oral P2Y12 inhibitor treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention: prevalence, predictors and short-term outcome.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Piperazines; Practice Patterns, Physicians'; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Fractalkine promotes platelet activation and vascular dysfunction in congestive heart failure.
Topics: Adenosine Diphosphate; Animals; Aorta; Cells, Cultured; Chemokine CX3CL1; Clopidogrel; CX3C Chemokine Receptor 1; Drug Resistance; Endothelial Cells; Heart Failure; Humans; Male; Platelet Activation; Rats; Rats, Wistar; Receptors, Chemokine; Ticlopidine; Up-Regulation; Vasodilation | 2014 |
Thrombin-induced platelet-fibrin clot strength: relation to high on-clopidogrel platelet reactivity, genotype, and post-percutaneous coronary intervention outcomes.
Topics: Aged; Aspirin; Blood Coagulation; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Fibrin; Genetic Testing; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Polymorphism, Genetic; Predictive Value of Tests; Prognosis; Thrombelastography; Thrombin; Ticlopidine; Treatment Outcome | 2014 |
Haemodialysis impairs clopidogrel but not aspirin responsiveness in patients with end-stage renal disease. Results of a pilot study.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Receptors, Purinergic P2Y12; Renal Dialysis; Risk; Ticlopidine | 2014 |
The influence of hypothermia on transfusion requirement in patients who received clopidogrel in proximity to off-pump coronary bypass surgery.
Topics: Aged; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Hypothermia; Male; Middle Aged; Retrospective Studies; Ticlopidine | 2014 |
Progressive hemorrhagic transformation following dual antiplatelet therapy.
Topics: Angiography, Digital Subtraction; Aspirin; Brain; Cerebral Angiography; Cerebral Hemorrhage; Clopidogrel; Constriction, Pathologic; Humans; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Middle Aged; Neuroprotective Agents; Stents; Stroke; Thrombectomy; Ticlopidine; Tomography, X-Ray Computed | 2014 |
A patient with HIV and tuberculosis with diminished clopidogrel response.
Topics: Antitubercular Agents; Clopidogrel; Drug Interactions; Drug Resistance; HIV Infections; HIV Protease Inhibitors; Humans; Isoniazid; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ritonavir; Ticlopidine; Tuberculosis | 2014 |
Variability in initial response to standard clopidogrel therapy, delayed conversion to clopidogrel hyper-response, and associated thromboembolic and hemorrhagic complications in patients undergoing endovascular treatment of unruptured cerebral aneurysms.
Topics: Cerebral Hemorrhage; Clopidogrel; Endovascular Procedures; Female; Humans; Intracranial Aneurysm; Intracranial Embolism; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Impact of cigarette smoking on P2Y12 receptor binding activity before and after clopidogrel therapy in patients with coronary artery disease.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Radioligand Assay; Receptors, Purinergic P2Y12; Smoking; Ticlopidine; Treatment Outcome | 2014 |
[Identification of the polymorphs of clopidogrel bisulfate based on the steric morphology parameters of crystals].
Topics: Clopidogrel; Crystallization; Neural Networks, Computer; Platelet Aggregation Inhibitors; Radiographic Image Interpretation, Computer-Assisted; ROC Curve; Synchrotrons; Ticlopidine; Tomography, X-Ray Computed | 2013 |
High on clopidogrel treatment platelet reactivity is frequent in acute and rare in elective stenting and can be functionally overcome by switch of therapy.
Topics: Aged; Blood Platelets; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine | 2014 |
Impact of mild hypothermia on platelet responsiveness to aspirin and clopidogrel: an in vitro pharmacodynamic investigation.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Hypothermia, Induced; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Treatment Outcome | 2014 |
Bleeding risk with triple antithrombotic therapy in patients with atrial fibrillation and drug-eluting stents.
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stroke; Thienopyridines; Ticlopidine; Warfarin | 2014 |
Antiplatelet drugs reduce the immunoinflammatory response in a rat model of periodontal disease.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Aspirin; Clopidogrel; Collagen; Connective Tissue; Disease Models, Animal; Gingiva; Inflammation Mediators; Male; Mandibular Diseases; Periodontitis; Peroxidase; Platelet Aggregation Inhibitors; Platelet Factor 4; Random Allocation; Rats; Rats, Sprague-Dawley; Ticlopidine | 2014 |
Risk factors for acute gastrointestinal bleeding following myocardial infarction in veteran patients who are prescribed clopidogrel.
Topics: Acute Disease; Age Factors; Aged; Anticoagulants; Chronic Disease; Clopidogrel; Female; Gastrointestinal Hemorrhage; Humans; Kaplan-Meier Estimate; Kidney Diseases; Liver Diseases; Male; Middle Aged; Myocardial Infarction; Ohio; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Veterans; Warfarin | 2014 |
Neurovascular protection of cilostazol in stroke-prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation.
Topics: Animals; Antigens; Aspirin; Cerebrovascular Circulation; Cilostazol; Clopidogrel; Disease Models, Animal; Endothelium; Fibrinolytic Agents; Male; Matrix Metalloproteinase 9; Neovascularization, Pathologic; Nerve Tissue Proteins; Pericytes; Proteoglycans; Rats; Rats, Inbred SHR; Stroke; Tetrazoles; Ticlopidine; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Asian study of clopidogrel (ASCLOP) responsiveness: the contributions of genetic and non-genetic factors.
Topics: Adult; Aged; Asian People; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Precision Medicine; Ticlopidine | 2014 |
Residual thrombin generation potential is inversely linked to the occurrence of atherothrombotic events in patients with peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Myocardial Infarction; P-Selectin; Peptide Fragments; Peripheral Arterial Disease; Platelet Activation; Platelet Aggregation Inhibitors; Prognosis; Proportional Hazards Models; Prospective Studies; Receptor, PAR-1; Recurrence; Stents; Stroke; Thrombin; Ticlopidine | 2014 |
Treating lacunar strokes occurring on aspirin: adding clopidogrel is not the simple solution.
Topics: Aspirin; Clopidogrel; Female; Humans; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; Stroke, Lacunar; Ticlopidine | 2014 |
Special Care Dentistry: Part 2. dental management of patients with drug-related acquired bleeding disorders.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplastic Agents; Blood Coagulation Disorders; Clopidogrel; Dental Care for Chronically Ill; Drug Therapy; Hemorrhagic Disorders; Hemostasis; Heparin; Humans; Phytotherapy; Platelet Aggregation Inhibitors; Prothrombin Time; Ticlopidine; Warfarin | 2013 |
Effect of platelet reactivity, endothelial function, and inflammatory status on outcomes in patients with stable angina pectoris on clopidogrel therapy.
Topics: Aged; Angina, Stable; Blood Platelets; Brachial Artery; Cell Count; Clopidogrel; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Multivariate Analysis; Platelet Activation; Platelet Aggregation Inhibitors; Stem Cells; Ticlopidine; Ultrasonography | 2014 |
Highlights from the issue.
Topics: Angiotensin Receptor Antagonists; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications, Cardiovascular; Risk Factors; Smoking; Socioeconomic Factors; Survival Rate; Ticlopidine | 2014 |
The relationship between fractional flow reserve, platelet reactivity and platelet leukocyte complexes in stable coronary artery disease.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Coronary Stenosis; Female; Fractional Flow Reserve, Myocardial; Humans; Leukocytes; Male; Middle Aged; Myocardial Ischemia; Platelet Activation; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine | 2013 |
Cigarette smoking and antiplatelet effects of aspirin monotherapy versus clopidogrel monotherapy in patients with atherosclerotic disease: results of a prospective pharmacodynamic study.
Topics: Adult; Aged; Aspirin; Atherosclerosis; Biomarkers; Blood Platelets; Clopidogrel; Cotinine; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Signal Transduction; Smoking; Thrombelastography; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Response to antiplatelet therapy and platelet reactivity to thrombin receptor activating peptide-6 in cardiovascular interventions: Differences between peripheral and coronary angioplasty.
Topics: Adenosine Diphosphate; Aged; Angioplasty; Angioplasty, Balloon, Coronary; Arachidonic Acid; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Monocytes; P-Selectin; Peptide Fragments; Percutaneous Coronary Intervention; Peripheral Arterial Disease; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prognosis; Stents; Ticlopidine | 2014 |
Repeat head computed tomography in anticoagulated traumatic brain injury patients: still warranted.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Brain Injuries; Clopidogrel; Cohort Studies; Disease Progression; Female; Head Injuries, Closed; Humans; Intracranial Hemorrhages; Logistic Models; Male; Middle Aged; Multivariate Analysis; Registries; Retrospective Studies; Risk Factors; Ticlopidine; Tomography, X-Ray Computed; Warfarin | 2014 |
Clopidogrel high-on-treatment platelet reactivity in acute ischemic stroke patients.
Topics: Aged; Blood Platelets; Cardiography, Impedance; Clopidogrel; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine | 2014 |
Increased risk for developing major adverse cardiovascular events in stented Chinese patients treated with dual antiplatelet therapy after concomitant use of the proton pump inhibitor.
Topics: Aged; Angioplasty, Balloon, Coronary; Asian People; Aspirin; Clopidogrel; Drug Combinations; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk; Stents; Survival Analysis; Ticlopidine | 2014 |
Clopidogrel and ticlopidine cross-reactivity-induced erythroderma following drug-eluting stenting.
Topics: Aged; Clopidogrel; Cross Reactions; Dermatitis, Exfoliative; Drug-Eluting Stents; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2013 |
The role of clinical parameters and of CYP2C19 G681 and CYP4F2 G1347A polymorphisms on platelet reactivity during dual antiplatelet therapy.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Thrombosis; Ticlopidine | 2014 |
Thrombelastography detects possible coagulation disturbance in patients with intracerebral hemorrhage with hematoma enlargement.
Topics: Aged; Blood Coagulation Disorders; Cerebral Hemorrhage; Clopidogrel; Data Interpretation, Statistical; Female; Hematoma; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Sample Size; Socioeconomic Factors; Thrombelastography; Thrombolytic Therapy; Ticlopidine | 2014 |
Cost-effectiveness of optimal use of acute myocardial infarction treatments and impact on coronary heart disease mortality in China.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Aspirin; China; Clopidogrel; Computer Simulation; Coronary Disease; Cost-Benefit Analysis; Electrocardiography; Heparin; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Markov Chains; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Ticlopidine | 2014 |
Antiplatelet therapy in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction: a retrospective observational study of prasugrel and clopidogrel.
Topics: Adult; Aged; Clopidogrel; Electrocardiography; Female; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Retrospective Studies; Thiophenes; Ticlopidine | 2014 |
[Combined correction of impairments of the functional state of the haemostasis system in patients with ischaemic stroke].
Topics: Adult; Aged; Anticoagulants; Brain Ischemia; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Hemostasis; Heparin; Humans; Male; Middle Aged; Motor Activity; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2013 |
A novel approach to assess the spontaneous gastrointestinal bleeding risk of antithrombotic agents using Apc(min/+) mice.
Topics: Age Factors; Animals; Benzimidazoles; Clopidogrel; Dabigatran; Disease Models, Animal; Drug Evaluation, Preclinical; Fibrinolytic Agents; Gastrointestinal Hemorrhage; Genes, APC; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pyrazoles; Pyridines; Pyridones; Risk Factors; Ticlopidine; Warfarin | 2014 |
Ticagrelor as an alternative in clopidogrel-associated neutropenia.
Topics: Acute Coronary Syndrome; Adenosine; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Substitution; Humans; Male; Neutropenia; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Female; Humans; Male; P-Selectin; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2014 |
Clopidogrel enhances periodontal repair in rats through decreased inflammation.
Topics: Alveolar Bone Loss; Animals; Aspirin; Cell Count; Chemokine CCL5; Chemokine CXCL12; Clopidogrel; Infusions, Parenteral; Male; Microvessels; Neutrophil Infiltration; Neutrophils; Osteoclasts; Periodontal Attachment Loss; Periodontitis; Periodontium; Platelet Aggregation Inhibitors; Platelet Factor 4; Platelet-Derived Growth Factor; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium Chloride; Ticlopidine | 2014 |
Variation in thromboxane B2 concentrations in serum and plasma in patients taking regular aspirin before and after clopidogrel therapy.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thromboxane B2; Ticlopidine; Treatment Outcome | 2015 |
Association of thrombin generation potential with platelet PAR-1 regulation and P-selectin expression in patients on dual antiplatelet therapy.
Topics: Adult; Aged; Aspirin; Biomarkers; Blood Platelets; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; P-Selectin; Peptide Fragments; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prothrombin; Receptor, PAR-1; Thiophenes; Thrombin; Ticlopidine | 2014 |
HPLC-PDA-ORD bioassay of S-(+) and R-(-) clopidogrel on rat dried blood spots.
Topics: Animals; Biological Assay; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Clopidogrel; Molecular Structure; Rats; Reproducibility of Results; Stereoisomerism; Ticlopidine; Time Factors | 2014 |
[Resistance to clopidogrel and polymorphism of P2RY12 and GPIIIA genes in patients with chronic coronary heart disease].
Topics: Alleles; Chronic Disease; Clopidogrel; Coronary Disease; DNA; Drug Resistance; Female; Genotype; Humans; Integrin beta3; Male; Middle Aged; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2013 |
Fixed-dose aspirin-clopidogrel combination enhances compliance to aspirin after acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Male; Medication Adherence; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
[The effects of cytochrome P450 2C19 genetic polymorphism on clopidogrel resistance and recent prognosis of patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prognosis; Ticlopidine | 2013 |
Impact of CYP2C19 polymorphism and proton pump inhibitors on platelet reactivity to clopidogrel and clinical outcomes following stent implantation.
Topics: Aged; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Polymorphism, Genetic; Rabeprazole; Stents; Ticlopidine | 2014 |
Adenosine diphosphate-induced single-platelet count aggregation and bleeding in clopidogrel-treated patients undergoing coronary artery bypass grafting.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Anesthesia; Aspirin; Blood Transfusion; Chest Tubes; Clopidogrel; Confidence Intervals; Coronary Artery Bypass; Critical Care; Erythrocyte Count; Female; Humans; Linear Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Postoperative Hemorrhage; Prospective Studies; Risk Factors; Ticlopidine | 2014 |
Diagnostic accuracy of mean platelet volume in prediction of clopidogrel resistance in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Area Under Curve; Blood Platelets; Clopidogrel; Cohort Studies; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Predictive Value of Tests; Prospective Studies; Ticlopidine | 2014 |
Immune thrombocytopenic purpura and myocardial infarction: a dilemma of management.
Topics: Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Disease Management; Female; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Mechanical Thrombolysis; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Purpura, Thrombocytopenic, Idiopathic; Stents; Ticlopidine; Treatment Outcome | 2013 |
Temporary adjunctive cilostazol vs clopidogrel loading for ST-segment elevation acute myocardial infarction.
Topics: Acute Disease; Aged; Cilostazol; Clopidogrel; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Tetrazoles; Ticlopidine | 2014 |
Antiatherosclerotic potential of clopidogrel: antioxidant and anti-inflammatory approaches.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atherosclerosis; Chemokine CCL2; Clopidogrel; Gene Expression Regulation; Humans; Interleukin-17; Rabbits; Ticlopidine; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2013 |
Analysis of gastrointestinal prophylaxis in patients receiving dual antiplatelet therapy with aspirin and clopidogrel.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Guideline Adherence; Hospitalization; Humans; Male; Middle Aged; Patient Readmission; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2014 |
Discrepancies in the primary PLATO trial publication and the FDA reviews.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials, Phase III as Topic; Clopidogrel; Congresses as Topic; Humans; Information Dissemination; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine; United States; United States Food and Drug Administration | 2014 |
Angiographic outcomes contradict platelet data in the PLATO trial: confusion over official trial substudies.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Circulation; Double-Blind Method; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Reproducibility of Results; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function.
Topics: Adenosine Diphosphate; Animals; Antidepressive Agents; Blotting, Western; Calcium; Carotid Artery Thrombosis; Clopidogrel; Cyproheptadine; Flow Cytometry; Hemorrhage; Humans; Immunoprecipitation; Indoles; Male; Mice; Mice, Inbred C57BL; Piperazines; Pizotyline; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Ticlopidine | 2014 |
[Rescue treatment in acute thrombosis of intracranial stents].
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Basilar Artery; Capillary Permeability; Cerebral Angiography; Clopidogrel; Equipment Design; Female; Fibrinolytic Agents; Hemorheology; Humans; Immunoglobulin Fab Fragments; Intracranial Aneurysm; Intracranial Thrombosis; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Salvage Therapy; Stents; Thrombolytic Therapy; Ticlopidine | 2014 |
Secondary prevention of atherothrombotic or cryptogenic stroke.
Topics: Aged; Anticholesteremic Agents; Antihypertensive Agents; Aspirin; Atorvastatin; Clopidogrel; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Life Style; Platelet Aggregation Inhibitors; Pyrroles; Recurrence; Risk Factors; Secondary Prevention; Stroke; Ticlopidine | 2014 |
Antiplatelet therapy for stable coronary artery disease in atrial fibrillation patients taking an oral anticoagulant: a nationwide cohort study.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Cohort Studies; Comorbidity; Coronary Artery Disease; Drug Therapy, Combination; Female; Hemorrhage; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Phenprocoumon; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; Vitamin K; Warfarin | 2014 |
[Real-world study in analysis of effects on concomitant medications with parenterally administered shenmai for coronary heart disease].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Disease; Drug Combinations; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Hospital Information Systems; Humans; Infusions, Parenteral; Logistic Models; Male; Middle Aged; Outcome Assessment, Health Care; Pragmatic Clinical Trials as Topic; Ticlopidine; Treatment Outcome; Young Adult | 2013 |
[Analysis of salvianolate injection combined with usual drugs in treatment of coronary heart disease in real world].
Topics: Aged; Aged, 80 and over; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Hospital Information Systems; Humans; Isosorbide Dinitrate; Male; Middle Aged; Plant Extracts; Pragmatic Clinical Trials as Topic; Propensity Score; Ticlopidine; Treatment Outcome | 2013 |
Smoking status and the effects of antiplatelet drugs.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Smoking; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2013 |
Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension.
Topics: Angiotensin II; Animals; Clopidogrel; Hypertension; Kidney; Male; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y12; Renal Circulation; Thromboxane B2; Ticlopidine | 2014 |
Warfarin: Impact on hemostasis after radial catheterization.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Cardiac Catheterization; Catheterization, Peripheral; Clopidogrel; Databases, Factual; Drug Administration Schedule; Female; Hemorrhage; Hemostasis; Hemostatic Techniques; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Radial Artery; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2015 |
Spontaneous omental bleeding in the setting of dual anti-platelet therapy with ticagrelor.
Topics: Adenosine; Aged; Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2014 |
Switching from aspirin to clopidogrel in patients with aspirin resistance after an ischemic stroke. Is it a good solution?
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Clopidogrel; Drug Resistance; Drug Substitution; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2014 |
Optimizing P2Y12 receptor inhibition in patients with acute coronary syndrome on the basis of platelet function testing: impact of prasugrel and high-dose clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Cause of Death; Clopidogrel; Combined Modality Therapy; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Purinergic P2Y Receptor Antagonists; Registries; Risk Assessment; Severity of Illness Index; Stents; Stroke; Survival Rate; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome | 2014 |
Dual antiplatelet therapy (clopidogrel and aspirin) is associated with increased all-cause mortality after carotid revascularization for asymptomatic carotid disease.
Topics: Aged; Alabama; Angioplasty; Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Patient Discharge; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stents; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Response to clopidogrel and its association with chronic kidney disease in noncardiogenic ischemic stroke patients.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Insufficiency, Chronic; Stroke; Ticlopidine; Treatment Outcome | 2014 |
Transcatheter closure of ruptured sinus of Valsalva aneurysm into the right ventricle with an Amplatzer Vascular Plug II.
Topics: Aortic Rupture; Aortography; Aspirin; Cardiac Catheterization; Clopidogrel; Drug Therapy, Combination; Echocardiography, Transesophageal; Equipment Design; Female; Hemodynamics; Humans; Middle Aged; Platelet Aggregation Inhibitors; Sinus of Valsalva; Ticlopidine; Treatment Outcome | 2015 |
Individualized strategy for clopidogrel suspension in patients undergoing off-pump coronary surgery for acute coronary syndrome: a case-control study.
Topics: Acute Coronary Syndrome; Case-Control Studies; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Propensity Score; Prospective Studies; Risk Factors; Suspensions; Ticlopidine | 2014 |
Positive clinical response to clopidogrel is independent of paraoxonase 1 Q192R and CYP2C19 genetic variants.
Topics: Aged; Alleles; Angina Pectoris; Aryldialkylphosphatase; Aspirin; Clopidogrel; Cohort Studies; Coronary Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Drug Therapy, Combination; Female; Genetic Variation; Genotype; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Risk Factors; Ticlopidine; Treatment Outcome | 2014 |
Impact of chronic kidney disease on platelet reactivity and outcomes of patients receiving clopidogrel and undergoing percutaneous coronary intervention.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Electrocardiography; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Prospective Studies; Renal Insufficiency, Chronic; Ticlopidine | 2014 |
CES1A -816C as a genetic marker to predict greater platelet clopidogrel response in patients with percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Female; Genetic Markers; Genetic Variation; Genotype; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Stents; Ticlopidine; Treatment Outcome | 2014 |
Initial experience with ticagrelor in patients with critical limb ischemia and high on-clopidogrel platelet reactivity undergoing complex peripheral endovascular procedures.
Topics: Adenosine; Adolescent; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Endovascular Procedures; Female; Follow-Up Studies; Humans; Leg; Limb Salvage; Male; Middle Aged; Peripheral Vascular Diseases; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Vessel wall, not platelet, P2Y12 potentiates early atherogenesis.
Topics: Adenosine; Animals; Apolipoproteins E; Atherosclerosis; Blood Platelets; Blood Vessels; Clopidogrel; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2014 |
Near-real-time monitoring of new drugs: an application comparing prasugrel versus clopidogrel.
Topics: Aged; Clopidogrel; Cohort Studies; Databases, Factual; Electronic Health Records; Female; Hemorrhage; Humans; Ischemia; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Product Surveillance, Postmarketing; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2014 |
Factor XIII Val34Leu polymorphism and recurrent myocardial infarction in patients with coronary artery disease.
Topics: Adult; Aged; Amino Acid Substitution; Aspirin; Clopidogrel; Coronary Artery Disease; Factor XIII; Female; Fibrin; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Thrombelastography; Ticlopidine | 2014 |
Association of upstream clopidogrel administration and myocardial reperfusion assessed by cardiac magnetic resonance imaging in patients with ST-elevation myocardial infarction.
Topics: Aged; Cardiac Catheterization; Clopidogrel; Female; Humans; Magnetic Resonance Angiography; Male; Microvessels; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Platelet Aggregation Inhibitors; Ticlopidine; Time-to-Treatment; Treatment Outcome | 2014 |
Hybrid strategy for unstable patients with severe carotid and cardiac disease requiring surgery.
Topics: Aged; Angioplasty, Balloon; Anticoagulants; Aspirin; Cardiac Surgical Procedures; Carotid Artery Diseases; Clopidogrel; Female; Heart Diseases; Hemodynamics; Heparin; Hospital Mortality; Hospitals, High-Volume; Hospitals, University; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Severity of Illness Index; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1.
Topics: Animals; Biotransformation; Clopidogrel; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Hepatocytes; Humans; Hydrolysis; Kidney; Madin Darby Canine Kidney Cells; Organic Anion Transport Protein 1; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Ticlopidine; Transfection | 2014 |
Duration of dual antiplatelet therapy following percutaneous coronary intervention on re-hospitalization for acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Multivariate Analysis; Patient Readmission; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Risk Factors; Taiwan; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Prospective registry of carotid artery stenting in Japan--investigation on device and antiplatelet for carotid artery stenting.
Topics: Aged; Aged, 80 and over; Aspirin; Carotid Arteries; Carotid Stenosis; Cilostazol; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Humans; Japan; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stents; Tetrazoles; Ticlopidine; Treatment Outcome | 2014 |
The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease.
Topics: Aged; Aryldialkylphosphatase; Aspirin; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; Carboxylic Ester Hydrolases; Case-Control Studies; China; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors; Stents; Ticlopidine | 2014 |
Clopidogrel and proton pump inhibitors.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Coronary Syndrome; Clinical Trials as Topic; Clopidogrel; Drug Combinations; Drug Interactions; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2014 |
Clopidogrel and proton pump inhibitors.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Clopidogrel; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2014 |
Treatment of blister-like aneurysms with the pipeline embolization device.
Topics: Adult; Aged; Aged, 80 and over; Aneurysm, Ruptured; Angioplasty; Aspirin; Basilar Artery; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral Angiography; Clopidogrel; Drug Therapy, Combination; Embolization, Therapeutic; Female; Follow-Up Studies; Heparin; Humans; Intracranial Aneurysm; Magnetic Resonance Angiography; Male; Middle Aged; Platelet Aggregation Inhibitors; Premedication; Retrospective Studies; Stents; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2014 |
Clinical outcomes in traumatic brain injury patients on preinjury clopidogrel: a prospective analysis.
Topics: Abbreviated Injury Scale; Aged; Aged, 80 and over; Brain Injuries; Clopidogrel; Female; Glasgow Coma Scale; Humans; Injury Severity Score; Intracranial Hemorrhage, Traumatic; Male; Neuroimaging; Patient Outcome Assessment; Platelet Aggregation Inhibitors; Propensity Score; Prospective Studies; Ticlopidine; Tomography, X-Ray Computed | 2014 |
High rates of prasugrel and ticagrelor non-responder in patients treated with therapeutic hypothermia after cardiac arrest.
Topics: Adenosine; Clopidogrel; Female; Flow Cytometry; Heart Arrest; Humans; Hypothermia, Induced; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Intracranial stenosis: impact of randomized trials on treatment preferences of US neurologists and neurointerventionists.
Topics: Angioplasty; Aspirin; Cerebral Arteries; Clopidogrel; Constriction, Pathologic; Drug Therapy, Combination; Drug Utilization; Fibrinolytic Agents; Health Care Surveys; Humans; Intracranial Arteriosclerosis; Neurology; Practice Patterns, Physicians'; Radiology, Interventional; Randomized Controlled Trials as Topic; Risk Reduction Behavior; Secondary Prevention; Stents; Stroke; Surveys and Questionnaires; Ticlopidine; United States; Warfarin | 2014 |
Safety evaluation of substituting clopidogrel for ticlopidine in Japanese patients with ischemic stroke--Hiroshima ticlopidine, clopidogrel safe exchange trial.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Clopidogrel; Drug Substitution; Female; Fibrinolytic Agents; Hemorrhage; Humans; Japan; Male; Middle Aged; Prospective Studies; Stroke; Ticlopidine; Treatment Outcome | 2014 |
Clopidogrel resistance in diabetic patient with acute myocardial infarction due to stent thrombosis.
Topics: Aged, 80 and over; Aspirin; Clopidogrel; Coronary Angiography; Diabetes Mellitus, Type 2; Drug Resistance; Electrocardiography; Heparin; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Thrombosis; Ticlopidine | 2014 |
Tips for GP trainees working in vascular surgery.
Topics: Anticholesteremic Agents; Aspirin; Blood Pressure; Clinical Competence; Clopidogrel; Education, Medical, Graduate; General Practice; Humans; Learning; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Simvastatin; Smoking Cessation; Ticlopidine; Vascular Diseases; Vascular Surgical Procedures | 2014 |
Prevalence of CYP2C19 variant alleles and pharmacodynamic variability of aspirin and clopidogrel in Native Americans.
Topics: Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Humans; Indians, North American; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2014 |
[Effect of drug interaction between clopidogrel and omeprazole in hospital readmision of patients by a recurrent acute coronary syndrome: a case-control study].
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Patient Readmission; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Ticlopidine | 2014 |
Differences in thrombus structure and kinetics in patients with type 2 diabetes mellitus after non ST elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2014 |
DTB Select: 3 | March 2014.
Topics: Alzheimer Disease; Antibodies, Monoclonal, Murine-Derived; Automobile Driving; Child; Chronic Pain; Clopidogrel; Hepatitis B; Histamine H2 Antagonists; Humans; Hypertension; Practice Guidelines as Topic; Practice Patterns, Physicians'; Proton Pump Inhibitors; Respiratory Tract Infections; Rituximab; Thiophenes; Ticlopidine | 2014 |
Cilostazol in acute myocardial infarction: new tricks for an old drug?
Topics: Cilostazol; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Tetrazoles; Ticlopidine | 2014 |
HeartWare left ventricular assist device thrombosis in aspirin non-responder.
Topics: Aged; Aspirin; Cardiomyopathy, Dilated; Clopidogrel; Drug Resistance; Drug Substitution; Fibrinolytic Agents; Heart Valve Prosthesis; Humans; International Normalized Ratio; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prosthesis Design; Thrombolytic Therapy; Thrombosis; Ticlopidine; Treatment Outcome; Ventricular Function, Left | 2014 |
Association between the microarray-based CYP2C19 genotyping assay and the platelet function test in cardiovascular patients receiving clopidogrel.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Alleles; Asian People; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Gene Expression; Genotype; Humans; Isoenzymes; Microarray Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Ticlopidine | 2014 |
Estimating the effects of time-varying exposures in observational studies using Cox models with stabilized weights adjustment.
Topics: Clopidogrel; Confounding Factors, Epidemiologic; Drug-Eluting Stents; Electronic Health Records; Hemorrhage; Humans; Myocardial Infarction; Observational Studies as Topic; Pharmacoepidemiology; Platelet Aggregation Inhibitors; Proportional Hazards Models; Ticlopidine; Time Factors | 2014 |
Effectiveness and safety of antiplatelet in stroke patients with end-stage renal disease undergoing dialysis.
Topics: Aged; Aspirin; Brain Ischemia; Clopidogrel; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Renal Dialysis; Retrospective Studies; Stroke; Ticlopidine; Treatment Outcome | 2014 |
CYP2C19 polymorphisms and coronary heart disease risk factors synergistically impact clopidogrel response variety after percutaneous coronary intervention.
Topics: Aged; Biomarkers; Blood Platelets; Body Mass Index; Cell Adhesion Molecules; China; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Diabetes Mellitus, Type 2; Drug Resistance; Female; Gene Frequency; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Oligonucleotide Array Sequence Analysis; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Phosphoproteins; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Risk Factors; Ticlopidine; Treatment Outcome | 2014 |
Safer heart-attack prevention for seniors with revised drug regimen. Half the normal dose of prasugrel, a lifesaving medication, is just as effective as the larger dose, and reduces risk of serious side effects.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Randomized Controlled Trials as Topic; Secondary Prevention; Thiophenes; Ticlopidine | 2013 |
Semi-mechanistic modelling and simulation of inhibition of platelet aggregation by antiplatelet agents.
Topics: Adult; Blood Platelets; Cilostazol; Clopidogrel; Half-Life; Humans; Models, Theoretical; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Salicylates; Tetrazoles; Ticlopidine; Young Adult | 2014 |
Point-of-care testing of clopidogrel-mediated platelet inhibition and risk for cardiovascular events after coronary angiography with or without percutaneous coronary intervention.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Angiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Patient Readmission; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; ROC Curve; Stents; Survival Analysis; Thrombosis; Ticlopidine | 2014 |
Dual antiplatelet therapy over 6 months increases the risk of bleeding after biodegradable polymer-coated sirolimus eluting stents implantation: insights from the CREATE study.
Topics: Aspirin; Biodegradable Plastics; Clopidogrel; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Evaluation of platelet response to different clopidogrel dosing regimens in patients with acute coronary syndrome in clinical practice.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Electrocardiography; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2015 |
Are we there yet? deciding when it is safe (and wise) to stop clopidogrel after stent implantation.
Topics: Clopidogrel; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors | 2014 |
Thromboelastograph with Platelet Mapping(TM) predicts postoperative chest tube drainage in patients undergoing coronary artery bypass grafting.
Topics: Adenosine Diphosphate; Aged; Algorithms; Blood Transfusion; Body Mass Index; Chest Tubes; Clopidogrel; Coronary Artery Bypass; Drainage; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Postoperative Hemorrhage; Predictive Value of Tests; Retrospective Studies; ROC Curve; Thrombelastography; Ticlopidine | 2014 |
Changing prescription pattern of omeprazole among patients receiving clopidogrel.
Topics: Clopidogrel; Drug Interactions; Drug Prescriptions; Drug Therapy, Combination; Follow-Up Studies; Gastrointestinal Diseases; Humans; Myocardial Ischemia; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Ticlopidine | 2014 |
Transient receptor potential ankyrin 1 (TRPA1) channel activation by the thienopyridine-type drugs ticlopidine, clopidogrel, and prasugrel.
Topics: Calcium; Calcium Channels; Cell Line; Clopidogrel; Enterochromaffin-like Cells; Gene Expression Regulation; HEK293 Cells; Humans; Mutation; Nerve Tissue Proteins; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Serotonin; Thiophenes; Ticlopidine; Time-Lapse Imaging; Transient Receptor Potential Channels; TRPA1 Cation Channel | 2014 |
Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.
Topics: Adenosine Diphosphate; Animals; Aorta; Blood Pressure; Clopidogrel; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Hypertension; Male; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y; Thionucleotides; Ticlopidine; Vascular Remodeling; Vasoconstriction; Vasodilation | 2014 |
Efficacy and safety of antiplatelet-combination therapy after drug-eluting stent implantation.
Topics: Aged; Antiplatyhelmintic Agents; Aspirin; Clopidogrel; Drug Combinations; Drug Resistance; Drug-Eluting Stents; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Function Tests; Prospective Studies; Tablets; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Aspirin improves outcome in high risk prostate cancer patients treated with radiation therapy.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Chemoradiotherapy; Clopidogrel; Drug Screening Assays, Antitumor; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Metastasis; Prostatic Neoplasms; Retrospective Studies; Risk; Ticlopidine; Treatment Outcome; Warfarin | 2014 |
Evaluation of two Japanese regulatory actions using medical information databases: a 'Dear Doctor' letter to restrict oseltamivir use in teenagers, and label change caution against co-administration of omeprazole with clopidogrel.
Topics: Adolescent; Age Factors; Antiviral Agents; Child; Clopidogrel; Databases, Factual; Drug and Narcotic Control; Drug Interactions; Humans; Interrupted Time Series Analysis; Japan; Omeprazole; Oseltamivir; Pharmacovigilance; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proton Pump Inhibitors; Regression Analysis; Ticlopidine; Young Adult | 2014 |
"East asian paradox": challenge for the current antiplatelet strategy of "one-guideline-fits-all races" in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Asia, Eastern; Asian People; Blood Platelets; Clopidogrel; Drug Administration Schedule; Evidence-Based Medicine; Female; Guideline Adherence; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome; Warfarin | 2014 |
[Feasibility of monitoring clopidogrel resistance with flow cytometric analysis of platelet vasodilator stimulated phosphoprotein phosphorylation].
Topics: Aged; Aged, 80 and over; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Drug Resistance; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Function Tests; Ticlopidine | 2014 |
Does the VerifyNow P2Y12 assay overestimate "therapeutic response" to clopidogrel? Insights using short thrombelastography.
Topics: Adenosine Diphosphate; Alprostadil; Clopidogrel; Drug Synergism; Humans; Platelet Aggregation; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombelastography; Ticlopidine | 2014 |
Prasugrel overcomes high on-clopidogrel platelet reactivity in the acute phase of acute coronary syndrome and maintains its antiplatelet potency at 30-day follow-up.
Topics: Acute Coronary Syndrome; Adolescent; Adult; Aged; Blood Platelets; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Ticlopidine; Treatment Outcome; Young Adult | 2014 |
Delayed therapy with clopidogrel and everolimus prevents progression of transplant arteriosclerosis and impairs humoral alloimmunity in murine aortic allografts.
Topics: Allografts; Animals; Aorta; Arteriosclerosis; Clopidogrel; Disease Progression; Everolimus; Immunity, Humoral; Isoantibodies; Mice; Mice, Inbred C57BL; Sirolimus; Ticlopidine | 2015 |
Interest of platelet inhibition monitoring in intracranial arterial stenosis before stenting.
Topics: Aged; Cell Adhesion Molecules; Clopidogrel; Constriction, Pathologic; Drug Monitoring; Drug Resistance; Humans; Intracranial Arterial Diseases; Male; Microfilament Proteins; Middle Cerebral Artery; Paresis; Phosphoproteins; Platelet Aggregation Inhibitors; Radiography; Ticlopidine | 2014 |
Triple versus dual antiplatelet therapy after percutaneous coronary intervention for coronary bifurcation lesions: results from the COBIS (COronary BIfurcation Stent) II Registry.
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Republic of Korea; Retrospective Studies; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome | 2015 |
Complications of hip fracture surgery on patients receiving clopidogrel therapy.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Hemiarthroplasty; Hip Fractures; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Ticlopidine | 2014 |
Comparative study of three modified numerical spectrophotometric methods: an application on pharmaceutical ternary mixture of aspirin, atorvastatin and clopedogrel.
Topics: Aspirin; Atorvastatin; Clopidogrel; Heptanoic Acids; Pyrroles; Spectrophotometry; Ticlopidine | 2014 |
Prognostic value of bleeding after percutaneous coronary intervention in patients with diabetes.
Topics: Abciximab; Aged; Antibodies, Monoclonal; Anticoagulants; Antithrombins; Aspirin; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Hemorrhage; Heparin; Hirudins; Humans; Immunoglobulin Fab Fragments; Logistic Models; Male; Middle Aged; Peptide Fragments; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Proportional Hazards Models; Recombinant Proteins; Risk Factors; Stents; Ticlopidine | 2014 |
Discontinuing clopidogrel: abrupt or tapered cessation?
Topics: Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Increased mean platelet volume is associated with non-responsiveness to clopidogrel.
Topics: Adenosine Diphosphate; Blood Platelets; Cells, Cultured; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Mean Platelet Volume; Middle Aged; Platelet Aggregation; Platelet Count; Platelet Function Tests; Ticlopidine | 2014 |
Aortic arch atheroma: a plaque of a different color or more of the same?
Topics: Anticoagulants; Aortic Diseases; Aspirin; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Warfarin | 2014 |
[Unexplained hypereosinophilia: too much or not enough?].
Topics: Clopidogrel; Coronary Artery Disease; Eosinophilia; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Desensitization to clopidogrel: a tailor-made protocol.
Topics: Aged; Clopidogrel; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
We need to do better for patients with non-ST-segment elevation acute coronary syndrome who are managed without revascularization.
Topics: Angina, Unstable; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Comparative effectiveness of clopidogrel in medically managed patients with unstable angina and non-ST-segment elevation myocardial infarction.
Topics: Aged; Angina, Unstable; Clopidogrel; Cohort Studies; Disease Management; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2014 |
A cautionary tale on the use of antiplatelet treatment following TURP.
Topics: Aged; Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Hematuria; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine; Transurethral Resection of Prostate; Urinary Bladder; Urinary Bladder Diseases | 2014 |
Does rebamipide prevent gastric mucosal injury in patients taking aspirin and clopidogrel?
Topics: Alanine; Anti-Ulcer Agents; Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Quinolones; Ticlopidine | 2014 |
Reverse evidence based medicine.
Topics: Cardiovascular Agents; Clopidogrel; Evidence-Based Medicine; Health Services Accessibility; Humans; Male; Middle Aged; Myocardial Ischemia; Poverty; Ramipril; Randomized Controlled Trials as Topic; Research Design; Simvastatin; Ticlopidine; Treatment Outcome | 2013 |
The impact of clopidogrel therapy on postoperative bleeding after robotic-assisted coronary artery bypass surgery.
Topics: Blood Transfusion; Chest Tubes; Clopidogrel; Coronary Artery Bypass; Drainage; Female; Humans; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Propensity Score; Robotic Surgical Procedures; Ticlopidine | 2014 |
High on-treatment platelet reactivity in patients with ischemic cerebrovascular disease: assessment of prevalence and stability over time using four platelet function tests.
Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Blood Platelets; Cell Adhesion Molecules; Cells, Cultured; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Purinergic P2Y12; Stroke; Ticlopidine; Time Factors | 2014 |
Does incorporation of thromboelastography improve bleeding prediction following adult cardiac surgery?
Topics: Age Factors; Aged; Blood Platelets; Cardiopulmonary Bypass; Chest Tubes; Clopidogrel; Female; Fibrinogen; Hematocrit; Humans; International Normalized Ratio; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Point-of-Care Systems; Postoperative Hemorrhage; Predictive Value of Tests; Retrospective Studies; ROC Curve; Sex Factors; Thrombelastography; Ticlopidine | 2014 |
A comparative cohort study on personalised antiplatelet therapy in PCI-treated patients with high on-clopidogrel platelet reactivity. Results of the ISAR-HPR registry.
Topics: Aged; Aged, 80 and over; Blood Platelets; Case-Control Studies; Clopidogrel; Coronary Thrombosis; Drug Resistance; Drug Substitution; Female; Germany; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Precision Medicine; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Risk Factors; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Tailoring platelet inhibition according to multiple electrode aggregometry decreases the rate of thrombotic complications after intracranial flow-diverting stent implantation.
Topics: Cerebrovascular Circulation; Clopidogrel; Endovascular Procedures; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Thrombosis; Ticlopidine | 2015 |
[Comparative assessment of antiaggregant efficacy of acetylsalicylic acid and clopidogrel in peripheral atherosclerosis].
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Lower Extremity; Male; Middle Aged; Patient Selection; Peripheral Arterial Disease; Platelet Aggregation; Platelet Aggregation Inhibitors; Severity of Illness Index; Therapeutic Equivalency; Ticlopidine; Treatment Outcome | 2014 |
Cost-effectiveness of genotype-guided and dual antiplatelet therapies in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Alleles; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Coronary Thrombosis; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Decision Support Techniques; Direct Service Costs; Drug Therapy, Combination; Drugs, Generic; Genotype; Hemorrhage; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prasugrel Hydrochloride; Quality-Adjusted Life Years; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
Severe left ventricular systolic dysfunction is independently associated with high on-clopidogrel platelet reactivity.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Percutaneous Coronary Intervention; Phosphoproteins; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Stroke; Stroke Volume; Ticlopidine; Ventricular Dysfunction, Left | 2014 |
Controversies in acute cardiovascular care.
Topics: Adenosine; Clinical Trials as Topic; Clopidogrel; Emergency Medical Services; Humans; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
Human neutrophil α-defensins are associated with adenosine diphosphate-inducible neutrophil-platelet aggregate formation and response to clopidogrel in patients with atherosclerosis.
Topics: Adenosine Diphosphate; alpha-Defensins; Atherosclerosis; C-Reactive Protein; Clopidogrel; Flow Cytometry; Humans; Interleukin-6; Neutrophils; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Prognosis of concomitant users of clopidogrel and proton-pump inhibitors in a high-risk population for upper gastrointestinal bleeding.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Male; Peptic Ulcer; Platelet Aggregation Inhibitors; Prognosis; Proton Pump Inhibitors; Risk; Sweden; Ticlopidine | 2014 |
Early clopidogrel versus prasugrel use among contemporary STEMI and NSTEMI patients in the US: insights from the National Cardiovascular Data Registry.
Topics: Aged; Clopidogrel; Drug Administration Schedule; Drug Utilization Review; Female; Guideline Adherence; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; Retrospective Studies; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome; United States | 2014 |
Acute generalized exanthematous pustulosis induced by clopidogrel.
Topics: Acute Generalized Exanthematous Pustulosis; Clopidogrel; Female; Humans; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Use of thromboelastography to tailor dual-antiplatelet therapy in patients undergoing treatment of intracranial aneurysms with the Pipeline embolization device.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Drug Therapy, Combination; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thrombelastography; Ticlopidine; Treatment Outcome | 2015 |
Levels and values of lipoprotein-associated phospholipase A2, galectin-3, RhoA/ROCK, and endothelial progenitor cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and clopidogrel combination therapy.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Aged; Base Sequence; Cilostazol; Clopidogrel; DNA Primers; Drug Therapy, Combination; Endothelial Progenitor Cells; Extremities; Female; Galectin 3; Humans; Ischemia; Male; Platelet Aggregation Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; Tetrazoles; Ticlopidine | 2014 |
Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy?
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Pulmonary Disease, Chronic Obstructive; Spirometry; Thrombocytosis; Ticlopidine | 2014 |
The devastating power of platelets in COPD exacerbations: can aspirin save lives in COPD?
Topics: Aspirin; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Pulmonary Disease, Chronic Obstructive; Thrombocytosis; Ticlopidine | 2014 |
Association of P2Y12 gene promoter DNA methylation with the risk of clopidogrel resistance in coronary artery disease patients.
Topics: Aged; Clopidogrel; Coronary Artery Disease; DNA Methylation; Drug Resistance; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Promoter Regions, Genetic; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Treatment Failure | 2014 |
Expert position paper on the management of antiplatelet therapy in patients undergoing coronary artery bypass graft surgery.
Topics: Adenosine; Aspirin; Blood Platelets; Clopidogrel; Consensus; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Piperazines; Platelet Aggregation Inhibitors; Postoperative Care; Prasugrel Hydrochloride; Preoperative Care; Purinergic P2Y Receptor Antagonists; Risk Assessment; Risk Factors; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
Subacute bioresorbable vascular scaffold thrombosis: a report of 2 cases.
Topics: Absorbable Implants; Adenosine; Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Stenosis; Coronary Thrombosis; Coronary Vessels; Drug-Eluting Stents; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
Successful multidisciplinary treatment of hilar cholangiocarcinoma in a patient with complicated new-onset coronary artery disease.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Chemotherapy, Adjuvant; Cholangiocarcinoma; Clopidogrel; Combined Modality Therapy; Coronary Artery Disease; Hepatectomy; Humans; Jejunostomy; Male; Neoadjuvant Therapy; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2014 |
Identification of alcohol-dependent clopidogrel metabolites using conventional liquid chromatography/triple quadrupole mass spectrometry.
Topics: Alcohols; Chromatography, High Pressure Liquid; Clopidogrel; Esterification; Humans; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Ticlopidine | 2014 |
Cytochrome p450 gene variants, race, and mortality among clopidogrel-treated patients after acute myocardial infarction.
Topics: Adult; Aged; Black People; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Humans; Male; Middle Aged; Myocardial Infarction; Polymorphism, Genetic; Prospective Studies; Ticlopidine; White People | 2014 |
Impact of early versus late clopidogrel discontinuation on stent thrombosis following percutaneous coronary intervention with first- and second-generation drug-eluting stents.
Topics: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Combined Modality Therapy; Coronary Angiography; Coronary Stenosis; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Eluting Stents; Everolimus; Female; Follow-Up Studies; Graft Occlusion, Vascular; Hospital Mortality; Humans; Male; Middle Aged; Paclitaxel; Prosthesis Failure; Registries; Retrospective Studies; Severity of Illness Index; Sirolimus; Survival Analysis; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome; Withholding Treatment | 2014 |
[Hematemesis in an 80-year-old patient with chest pain and nausea].
Topics: Aged, 80 and over; Aspirin; Chest Pain; Clopidogrel; Esophageal Diseases; Esophagoscopy; Female; Hematemesis; Hematoma; Humans; Nausea; Platelet Aggregation Inhibitors; Rupture, Spontaneous; Ticlopidine; Tomography, X-Ray Computed | 2015 |
SUPERA interwoven nitinol Stent Outcomes in Above-Knee IntErventions (SAKE) study.
Topics: Aged; Aged, 80 and over; Alloys; Ankle Brachial Index; Aspirin; Clopidogrel; Constriction, Pathologic; Drug Therapy, Combination; Endovascular Procedures; Female; Femoral Artery; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Popliteal Artery; Predictive Value of Tests; Prosthesis Design; Radiography; Retrospective Studies; Severity of Illness Index; Stents; Ticlopidine; Time Factors; Treatment Outcome; Vascular Patency | 2014 |
Triple antithrombotic therapy: risky but sometimes necessary.
Topics: Anticoagulants; Aspirin; Benzimidazoles; beta-Alanine; Clinical Trials as Topic; Clopidogrel; Dabigatran; Drug Therapy, Combination; Humans; Morpholines; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyrazoles; Pyridones; Rivaroxaban; Thiophenes; Ticlopidine; Vitamin K | 2014 |
Stent placement for complex middle cerebral artery aneurysms.
Topics: Adult; Aged; Aneurysm, Ruptured; Anticoagulants; Aspirin; Cerebral Angiography; Clopidogrel; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Failure; Treatment Outcome | 2014 |
Is it appropriate to compare the results from two clinical trials with one drug in common?
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Thiophenes; Ticagrelor; Ticlopidine | 2013 |
Successful treatment of bleeding large duodenal gastrointestinal stromal tumour in a patient under dual antiplatelet therapy after recent drug-eluting coronary stent implantation.
Topics: Aged; Aspirin; Benzamides; Chemotherapy, Adjuvant; Clopidogrel; Coronary Stenosis; Drug-Eluting Stents; Duodenal Neoplasms; Gastrointestinal Hemorrhage; Gastrointestinal Stromal Tumors; Hemostatic Techniques; Humans; Imatinib Mesylate; Male; Neoadjuvant Therapy; Piperazines; Platelet Aggregation Inhibitors; Pyrimidines; Ticlopidine | 2014 |
Factors determining the total serum antioxidant capacity in men with coronary heart disease--the powerful effect of treatment with thienopyridines.
Topics: Adult; Aged; Antioxidants; Biomarkers; Cardiotonic Agents; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Humans; Male; Middle Aged; Oxidative Stress; Thienopyridines; Ticlopidine; Uric Acid | 2014 |
Longitudinal assessment of von Willebrand factor antigen and von Willebrand factor propeptide in response to alteration of antiplatelet therapy after TIA or ischaemic stroke.
Topics: Adult; Aged; Aspirin; Clopidogrel; Dipyridamole; Enzyme-Linked Immunosorbent Assay; Female; Humans; Ischemic Attack, Transient; Longitudinal Studies; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Protein Precursors; Statistics, Nonparametric; Stroke; Ticlopidine; Time Factors; von Willebrand Factor | 2014 |
[A new technology for evaluating pharmacodynamics of antiaggregants].
Topics: Adult; Aspirin; Blood Coagulation; Clopidogrel; Cyclooxygenase 1; Fibrinogen; Healthy Volunteers; Humans; Kinetics; Male; Pentoxifylline; Platelet Aggregation Inhibitors; Precision Medicine; Receptors, Purinergic P2; Thrombelastography; Thrombin; Ticlopidine | 2014 |
Thrombotic and bleeding events after coronary stenting according to clopidogrel and aspirin platelet reactivity: VerifyNow French Registry (VERIFRENCHY).
Topics: Aged; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Female; France; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Registries; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2014 |
Fixed combination dual antiplatelet therapy and the risk of stent thrombosis.
Topics: Aged, 80 and over; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Medication Adherence; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2014 |
Pharmacogenetic landscape of clopidogrel in north Indians suggest distinct interpopulation differences in allele frequencies.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Clopidogrel; Data Mining; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; India; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2014 |
Platelet reactivity in comatose survivors of cardiac arrest undergoing percutaneous coronary intervention and hypothermia.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Blood Platelets; Cardiopulmonary Resuscitation; Case-Control Studies; Clopidogrel; Cohort Studies; Coma; Coronary Angiography; Eptifibatide; Female; Humans; Hypothermia, Induced; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Peptides; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Receptors, Thrombin; Ticlopidine | 2015 |
Pharmacologic strategy for one repeated stent thrombosis patient with hyporesponsiveness to standard dual antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Electrocardiography; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Smoking; Stents; Thrombosis; Ticlopidine | 2015 |
Acute coronary thrombosis and multiple coronary aneurysms in a 22-year-old man with the human immunodeficiency virus.
Topics: Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Coronary Aneurysm; Coronary Angiography; Coronary Thrombosis; Electrocardiography; HIV; HIV Infections; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome; Young Adult | 2014 |
Viewpoint: "underutilisation of novel antiplatelet agents--myths, generics, and economics".
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials as Topic; Clopidogrel; Cost-Benefit Analysis; Drug Therapy, Combination; Drug Utilization; Evidence-Based Medicine; Humans; Japan; Marketing; Piperazines; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
There's life in the old dog yet: clopidogrel competing with prasugrel and ticagrelor for treatment of ACS patients.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials as Topic; Clopidogrel; Drug Substitution; Drug Therapy, Combination; Economic Competition; Humans; Piperazines; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Utilisation of novel anti-platelet agents: evidence, guidelines and proven patients' value.
Topics: Acute Coronary Syndrome; Adenosine; Clinical Trials as Topic; Clopidogrel; Costs and Cost Analysis; Drug Utilization; Evidence-Based Medicine; Humans; International Cooperation; Marketing; Patient Satisfaction; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
Bone marrow toxicity induced by clopidogrel.
Topics: Bone Marrow; Bone Marrow Diseases; Clopidogrel; Female; Humans; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Switching patients from clopidogrel to novel P2Y12 receptor inhibitors in acute coronary syndrome: comparative effects of prasugrel and ticagrelor on platelet reactivity.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Blood Platelets; Clopidogrel; Drug Substitution; Female; Humans; Male; Middle Aged; Piperazines; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine; Treatment Outcome | 2014 |
Impact of CYP2C19 polymorphism on clinical outcome following coronary stenting is more important in non-diabetic than diabetic patients.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Diabetes Mellitus; Female; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Stents; Ticlopidine | 2014 |
Endoscopic procedures in patients under clopidogrel or dual antiplatelet therapy: a survey among German gastroenterologists and current guidelines.
Topics: Clopidogrel; Endoscopy, Gastrointestinal; Gastroenterology; Germany; Guideline Adherence; Health Care Surveys; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Ticlopidine | 2014 |
Clopidogrel: what is a cardiologist to do?
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Labeling; Genotype; Humans; Platelet Aggregation Inhibitors; Ticlopidine; United States; United States Food and Drug Administration | 2014 |
Thromboembolic complications in patients with clopidogrel resistance after coil embolization for unruptured intracranial aneurysms.
Topics: Adult; Aged; Blood Vessel Prosthesis; Clopidogrel; Diffusion Magnetic Resonance Imaging; Drug Resistance; Embolization, Therapeutic; Endovascular Procedures; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine | 2014 |
Perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and non-cardiac surgery: a consensus document from Italian cardiological, surgical and anaesthesiological societies.
Topics: Anesthesiology; Aspirin; Cardiac Surgical Procedures; Cardiology; Clopidogrel; Eptifibatide; Hemorrhage; Humans; Italy; Myocardial Ischemia; Peptides; Perioperative Care; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Risk Assessment; Societies, Medical; Stents; Surgical Procedures, Operative; Thoracic Surgery; Ticlopidine; Tirofiban; Tyrosine | 2014 |
Platelet factor XIIIa release during platelet aggregation and plasma clot strength measured by thrombelastography in patients with coronary artery disease treated with clopidogrel.
Topics: Blood Platelets; Clopidogrel; Coronary Artery Disease; Factor XIIIa; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombelastography; Ticlopidine | 2015 |
Prasugrel increases the need for platelet transfusions and surgical reexploration rates compared with clopidogrel in coronary artery bypass surgery.
Topics: Anticoagulants; Clopidogrel; Coronary Artery Bypass; Forecasting; Humans; Logistic Models; Piperazines; Platelet Transfusion; Postoperative Hemorrhage; Prasugrel Hydrochloride; Preoperative Period; Purinergic P2Y Receptor Antagonists; Reoperation; Thiophenes; Ticlopidine | 2015 |
Direct healthcare costs and cost-effectiveness of acute coronary syndrome secondary prevention with ticagrelor compared to clopidogrel: economic evaluation from the public payer's perspective in Poland based on the PLATO trial results.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Aged; Aged, 80 and over; Clopidogrel; Cost-Benefit Analysis; Female; Humans; Male; Middle Aged; Models, Economic; Poland; Secondary Prevention; State Medicine; Ticagrelor; Ticlopidine | 2014 |
Multi-parameter assessment of platelet inhibition and its stability during aspirin and clopidogrel therapy.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Development of a multiplex and cost-effective genotype test toward more personalized medicine for the antiplatelet drug clopidogrel.
Topics: Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Genotyping Techniques; Humans; Multiplex Polymerase Chain Reaction; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Precision Medicine; Receptors, Purinergic P2Y12; Republic of Korea; Sequence Analysis, DNA; Ticlopidine | 2014 |
[Drug-drug interactions in nursing home patients].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Clopidogrel; Databases, Factual; Dopamine Antagonists; Drug Interactions; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Humans; Nursing Homes; Platelet Aggregation Inhibitors; Polypharmacy; Proton Pump Inhibitors; Ticlopidine; Warfarin | 2014 |
Projected inhibition of platelet aggregation with ticagrelor twice daily vs. clopidogrel once daily based on patient adherence data (the TWICE project).
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Drug Administration Schedule; Humans; Medication Adherence; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2014 |
Delay in filling first clopidogrel prescription after coronary stenting is associated with an increased risk of death and myocardial infarction.
Topics: Aged; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Improving outcomes with bivalirudin in primary percutaneous coronary intervention.
Topics: Anticoagulants; Clopidogrel; Heparin; Hirudins; Humans; Male; Myocardial Infarction; Peptide Fragments; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Recombinant Proteins; Thiophenes; Ticlopidine | 2014 |
[Multination clinical trials: what is the relevance and what are the lessons from across-country differences?].
Topics: Acute Coronary Syndrome; Adenosine; Americas; Benzazepines; Cardiovascular Agents; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Ethnicity; Europe; Female; Georgia (Republic); Heart Failure; Humans; Internationality; Male; Metoprolol; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Russia; Sample Size; Spironolactone; Ticagrelor; Ticlopidine; Tolvaptan | 2014 |
Patients carrying CYP2C19 loss of function alleles have a reduced response to clopidogrel therapy and a greater risk of in-stent restenosis after endovascular treatment of lower extremity peripheral arterial disease.
Topics: Aged; Alleles; Angiography, Digital Subtraction; Ankle Brachial Index; Arteriosclerosis Obliterans; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Endovascular Procedures; Female; Femoral Artery; Follow-Up Studies; Genotype; Graft Occlusion, Vascular; Humans; Leg; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Prosthesis Failure; Stents; Ticlopidine; Tomography, X-Ray Computed; Ultrasonography, Doppler, Duplex | 2014 |
Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo.
Topics: Animals; Blood Coagulation; Blotting, Western; Cell-Derived Microparticles; Clopidogrel; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique; Integrins; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; P-Selectin; Pancreatic Neoplasms; Platelet Activation; Platelet Aggregation Inhibitors; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thromboplastin; Thrombosis; Ticlopidine; Tumor Cells, Cultured | 2015 |
Posttreatment platelet reactivity on clopidogrel is associated with the risk of adverse events after off-pump coronary artery bypass.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Coronary Artery Bypass, Off-Pump; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; ROC Curve; Ticlopidine | 2014 |
The quality of antiplatelet and anticoagulant medication administration among ST-segment elevation myocardial infarction patients transferred for primary percutaneous coronary intervention.
Topics: Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Early Medical Intervention; Female; Guideline Adherence; Heparin; Heparin, Low-Molecular-Weight; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Patient Transfer; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Practice Guidelines as Topic; Pyridines; Recombinant Proteins; Retrospective Studies; Ticlopidine; Time-to-Treatment | 2014 |
Acute coronary syndrome antiplatelet alternatives in clopidogrel allergy.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Aged; Clopidogrel; Drug Hypersensitivity; Female; Humans; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Ticagrelor; Ticlopidine | 2014 |
Gender differences in hemorheological parameters and in in vitro platelet aggregation in acetylsalicylic acid and clopidogrel treated vascular patients.
Topics: Aged; Aspirin; Clopidogrel; Erythrocyte Aggregation; Female; Fibrinogen; Hematocrit; Humans; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Rheology; Ticlopidine | 2014 |
Adverse cardiovascular outcomes in relation to suboptimal antithrombotic therapy use in patients undergoing peripheral artery disease angioplasty: lost opportunities?
Topics: Aged; Aged, 80 and over; Angioplasty; Anticoagulants; Aspirin; Clopidogrel; Cohort Studies; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Peripheral Arterial Disease; Retrospective Studies; Ticlopidine; Treatment Outcome | 2015 |
Cost-effectiveness of clopidogrel-aspirin versus aspirin alone for acute transient ischemic attack and minor stroke.
Topics: Aspirin; China; Clopidogrel; Cost-Benefit Analysis; Drug Costs; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Male; Markov Chains; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Stroke; Ticlopidine | 2014 |
Exploring consumer opinions on the presentation of side-effects information in Australian Consumer Medicine Information leaflets.
Topics: Aged; Antihypertensive Agents; Attitude; Clopidogrel; Cognition; Drug-Related Side Effects and Adverse Reactions; Female; Focus Groups; Health Literacy; Heuristics; Humans; Male; Middle Aged; New South Wales; Pamphlets; Platelet Aggregation Inhibitors; Prescription Drugs; Ramipril; Terminology as Topic; Ticlopidine | 2016 |
[Individualized medicine. DNA tests for better treatment safety].
Topics: Antidepressive Agents; Biotransformation; Clopidogrel; Dose-Response Relationship, Drug; Forecasting; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metabolic Clearance Rate; Precision Medicine; Sequence Analysis, DNA; Tamoxifen; Ticlopidine; Treatment Outcome | 2014 |
Aortic thrombosis secondary to clopidogrel-related thrombotic thrombocytopenic purpura.
Topics: Aged; Aorta, Abdominal; Aortic Diseases; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Thrombosis; Ticlopidine; Tomography, X-Ray Computed | 2014 |
Proton-pump inhibitors in patients requiring antiplatelet therapy: new FDA labeling.
Topics: Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Antagonism; Drug Labeling; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine; United States; United States Food and Drug Administration | 2014 |
Delayed ischemic stroke after stent-assisted coil placement in cerebral aneurysm: characteristics and optimal duration of preventative dual antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Stents; Stroke; Ticlopidine; Treatment Outcome | 2014 |
Cholesterol embolization syndrome with an atypical proximal presentation simulating calciphylaxis.
Topics: Aspirin; Back; Buttocks; Calciphylaxis; Cardiac Catheterization; Clopidogrel; Diagnosis, Differential; Embolism, Cholesterol; Erythema; Female; Humans; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Skin Ulcer; Thigh; Ticlopidine | 2014 |
Risk and benefit of dual antiplatelet treatment among non-revascularized myocardial infarction patients in different age groups.
Topics: Age Distribution; Age Factors; Aged; Aspirin; Cause of Death; Clopidogrel; Denmark; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Propensity Score; Registries; Retrospective Studies; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Resolution of clopidogrel-associated polyarthritis after conversion to prasugrel.
Topics: Aged; Arthritis; Clopidogrel; Humans; Male; Piperazines; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticlopidine | 2014 |
The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping.
Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Catalysis; Chromatography, Liquid; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Kinetics; Mephenytoin; Omeprazole; Pharmacogenetics; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Tandem Mass Spectrometry; Ticlopidine | 2014 |
Uncovering the shroud on antiplatelet therapy for patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.
Topics: Clopidogrel; Electrocardiography; Female; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Prasugrel Hydrochloride; Thiophenes; Thrombolytic Therapy; Ticlopidine | 2014 |
Pre-specified vs. post-hoc subgroup analyses: are we wiser before or after a trial has been performed?
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2014 |
The roles and issues of P2Y12 percent inhibition assessed by VerifyNow assay for patients undergoing Neurointervention: a prospective study.
Topics: Aged; Brain Ischemia; Clopidogrel; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome | 2014 |
Early ambulance initiation versus in-hospital initiation of high dose clopidogrel in ST-segment elevation myocardial infarction.
Topics: Aged; Clopidogrel; Cohort Studies; Electrocardiography; Emergency Medical Services; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Survival Analysis; Ticlopidine; Treatment Outcome; Vascular Patency | 2014 |
ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective Acute Myocardial Infarction Study): a retrospective analysis of hospital data.
Topics: Aged; Aspirin; China; Clopidogrel; Female; Fibrinolytic Agents; Healthcare Disparities; Hospital Mortality; Hospitals, Rural; Hospitals, Urban; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Patient Admission; Percutaneous Coronary Intervention; Quality of Health Care; Retrospective Studies; Ticlopidine; Treatment Outcome | 2015 |
[New aspects of stroke medicine].
Topics: Anticoagulants; Clopidogrel; Fibrinolytic Agents; Humans; Intermittent Pneumatic Compression Devices; Platelet Aggregation Inhibitors; Stroke; Thrombectomy; Thromboembolism; Ticlopidine; Tissue Plasminogen Activator | 2014 |
Differential compaction behaviour of roller compacted granules of clopidogrel bisulphate polymorphs.
Topics: Clopidogrel; Compressive Strength; Drug Compounding; Particle Size; Powders; Pressure; Stress, Mechanical; Tablets; Ticlopidine | 2014 |
Comparative effects of the anti-platelet drugs, clopidogrel, ticlopidine, and cilostazol on aspirin-induced gastric bleeding and damage in rats.
Topics: Animals; Aspirin; Cilostazol; Clopidogrel; Hemoglobins; Hemorrhage; Male; Peroxidase; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stomach Diseases; Tetrazoles; Ticlopidine | 2014 |
Prevalence of deep vein thrombosis in acutely admitted ambulatory non-surgical intensive care unit patients.
Topics: Aged; Aged, 80 and over; Anticoagulants; APACHE; Aspirin; Clopidogrel; Female; Fibrin Fibrinogen Degradation Products; Germany; Heparin; Humans; Intensive Care Units; Male; Middle Aged; Outpatient Clinics, Hospital; Patient Admission; Platelet Aggregation Inhibitors; Prevalence; Prospective Studies; Pulmonary Embolism; Risk Factors; Ticlopidine; Venous Thromboembolism; Venous Thrombosis | 2014 |
[Association between clopidogrel resistance and polymorphism of platelet adenosine diphosphate receptor in patients with coronary atherosclerotic disease].
Topics: Adolescent; Adult; Aged; Clopidogrel; Coronary Artery Disease; Drug Resistance; Female; Humans; Male; Middle Aged; Mutation; Polymorphism, Genetic; Prognosis; Receptors, Purinergic P2Y12; Ticlopidine; Young Adult | 2014 |
Clinical outcomes associated with proton pump inhibitor use among clopidogrel-treated patients within CYP2C19 genotype groups following acute myocardial infarction.
Topics: Adult; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2015 |
Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation.
Topics: Alleles; Animals; Chlorocebus aethiops; Clopidogrel; COS Cells; Cytochrome P-450 CYP2C19; Genetic Variation; Humans; Liver; Oxidation-Reduction; Ticlopidine | 2015 |
Spontaneous resolution of nontraumatic chronic subdural hematoma associated with anti-aggregation therapy.
Topics: Aged; Aspirin; Clopidogrel; Diuretics, Osmotic; Female; Fibrin Fibrinogen Degradation Products; Follow-Up Studies; Hematoma, Subdural, Chronic; Humans; Mannitol; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Remission, Spontaneous; Ticlopidine; Tomography, X-Ray Computed | 2014 |
Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Aspirin; Cardiotonic Agents; Clopidogrel; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Preclinical; Enzyme Induction; Lipoxins; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase Type III; Pyrazoles; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Ticagrelor; Ticlopidine; Triazoles; Up-Regulation | 2014 |
The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: a retrospective analysis of the FEATHER study.
Topics: Adult; Aged; Biomarkers; Blood Platelets; Body Mass Index; Body Size; Body Surface Area; Body Weight; Cell Adhesion Molecules; Clopidogrel; Coronary Artery Disease; Drug Dosage Calculations; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Retrospective Studies; Ticlopidine; Treatment Outcome | 2014 |
An atypical presentation of an extremely late stent thrombosis after more than 7 years (2634 days) of DES implantation in a patient without obvious risk factors on regular dual antiplatelet therapy.
Topics: Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Ticlopidine; Time Factors | 2014 |
Real-world observations with prasugrel compared to clopidogrel in acute coronary syndrome patients treated with percutaneous coronary intervention in the United States.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Hemorrhage; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stents; Stroke; Thiophenes; Ticlopidine; Treatment Outcome; United States | 2014 |
Association between silent embolic cerebral infarction and continuous increase of P2Y12 reaction units after neurovascular stenting.
Topics: Aspirin; Cerebral Infarction; Clopidogrel; Drug Resistance; Endovascular Procedures; Female; Humans; Intracranial Embolism; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Stents; Ticlopidine | 2014 |
Comparison of loading with maintenance dose of clopidogrel on platelet reactivity in Chinese with different CYP2C19 genotypes prior to percutaneous coronary intervention.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Prospective Studies; Ticlopidine | 2014 |
The clopidogrel conundrum.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Drug Interactions; Esomeprazole; Genotype; Humans; Omeprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2014 |
Clopidogrel, CYP2C19 and proton pump inhibitors: what we know and what it means.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Humans; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2014 |
Ticagrelor and the prevention of cardiovascular mortality: more than just platelet inhibition?
Topics: Acute Coronary Syndrome; Adenosine; Cause of Death; Clopidogrel; Female; Humans; Male; Ticagrelor; Ticlopidine | 2014 |
Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness.
Topics: Aged; Alleles; ATP Binding Cassette Transporter, Subfamily B; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Drug-Eluting Stents; Female; Humans; Male; Microfilament Proteins; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenetics; Phosphoproteins; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Ticlopidine | 2014 |
The chronovariability of platelet reactivity: a hurdle in the road to personalized antiplatelet therapy?
Topics: Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Platelet Aggregation; Ticlopidine | 2014 |
Salvianolic acid B inhibits platelets as a P2Y12 antagonist and PDE inhibitor: evidence from clinic to laboratory.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Benzofurans; Blood Platelets; Clopidogrel; Drugs, Chinese Herbal; Humans; Male; Middle Aged; Phosphodiesterase Inhibitors; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Salvia miltiorrhiza; Ticlopidine | 2014 |
Risk of bleeding and adverse outcomes predicted by thromboelastography platelet mapping in patients taking clopidogrel within 7 days of non-cardiac surgery.
Topics: Aged; Case-Control Studies; Clopidogrel; Erythrocyte Transfusion; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Postoperative Hemorrhage; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Reoperation; Risk Factors; Thrombelastography; Ticlopidine; Treatment Outcome | 2014 |
Lower GI bleeding risk of nonsteroidal anti-inflammatory drugs and antiplatelet drug use alone and the effect of combined therapy.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Clopidogrel; Colonic Diseases; Colonoscopy; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Rectal Diseases; Risk Factors; Ticlopidine | 2014 |
In-hospital switching between clopidogrel and prasugrel among patients with acute myocardial infarction treated with percutaneous coronary intervention: insights into contemporary practice from the national cardiovascular data registry.
Topics: Acute Disease; Age Factors; Aged; Clopidogrel; Drug Substitution; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Postoperative Complications; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Recurrence; Registries; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; United States | 2014 |
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.
Topics: Adenosine Diphosphate; Animals; Apyrase; Clopidogrel; Coronary Circulation; Dogs; Fibrinolysis; Hemorrhage; Humans; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Piperazines; Platelet Aggregation; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Tissue Plasminogen Activator; Treatment Outcome; Vascular Patency | 2014 |
Single nucleotide polymorphism of CYP3A5*3 contributes to clopidogrel resistance in coronary artery disease patients among Tamilian population.
Topics: Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP3A; Drug Resistance; Ethnicity; Humans; India; Pharmacogenetics; Platelet Aggregation; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Ticlopidine | 2014 |
Appropriateness of clopidogrel use according to current recommendations.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Clinical Audit; Clopidogrel; Electronic Health Records; Female; Guideline Adherence; Health Care Costs; Humans; Male; Middle Aged; Nervous System Diseases; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prescription Drug Misuse; Retrospective Studies; Spain; Ticlopidine; Time Factors | 2014 |
Short bowel syndrome and clopidogrel non-responsiveness: a new indication for platelet aggregometry?
Topics: Adenosine; Aged; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Short Bowel Syndrome; Ticagrelor; Ticlopidine | 2014 |
Acute Carotid Artery Stent Thrombosis Due to Dual Antiplatelet Resistance.
Topics: Acute Disease; Aged; Aspirin; Carotid Artery Thrombosis; Carotid Artery, Internal; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Hemiplegia; Humans; Male; Platelet Aggregation Inhibitors; Stents; Stroke; Ticlopidine; Tomography, X-Ray Computed | 2015 |
Lower gastrointestinal bleeding associated with diclofenac topical patch in a patient with colonic mass and on antiplatelet therapy for atrial fibrillation.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Atrial Fibrillation; Clopidogrel; Colonic Neoplasms; Colonoscopy; Diclofenac; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Myofascial Pain Syndromes; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Transdermal Patch | 2014 |
Clopidogrel discontinuation within the first year after coronary drug-eluting stent implantation: an observational study.
Topics: Aged; Clopidogrel; Coronary Thrombosis; Denmark; Drug Administration Schedule; Drug Prescriptions; Drug-Eluting Stents; Female; Humans; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Residual platelet reactivity after clopidogrel loading in ST-elevation myocardial infarction patients undergoing a delayed catheterization. Impact on long term clinical events.
Topics: Aged; Blood Platelets; Cardiac Catheterization; Clopidogrel; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2014 |
First report of stent thrombosis after a switch therapy resulting from ticagrelor-related dyspnea.
Topics: Adenosine; Aged; Clopidogrel; Drug Substitution; Dyspnea; Humans; Male; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticagrelor; Ticlopidine | 2014 |
Global platelet hyperreactivity and elevated C-reactive protein levels predict long term mortality in STEMI patients.
Topics: Aged; Aspirin; Blood Platelets; C-Reactive Protein; Clopidogrel; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Stents; Ticlopidine | 2014 |
[Long-term cost-effectiveness of ticagrelor versus clopidogrel in acute coronary syndrome in Spain].
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Cost-Benefit Analysis; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Quality of Life; Spain; Ticagrelor; Ticlopidine; Time Factors | 2014 |
Reanalysis or redefinition of the hypothesis?
Topics: Angina, Unstable; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2015 |
Impact of aspirin and clopidogrel interruption on platelet function in patients undergoing major vascular surgery.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Preoperative Period; Ticlopidine; Vascular Surgical Procedures; Withholding Treatment | 2014 |
Safety of low-dose aspirin in endovascular treatment for intracranial atherosclerotic stenosis.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Constriction, Pathologic; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2014 |
Benefit of clopidogrel therapy in patients with myocardial infarction and chronic kidney disease-a Danish nation-wide cohort study.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Cohort Studies; Data Collection; Denmark; Female; Hemorrhage; Humans; Kidney Failure, Chronic; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Recurrence; Renal Dialysis; Renal Insufficiency, Chronic; Ticlopidine; Treatment Outcome | 2014 |
Association between peak neutrophil count, clopidogrel loading dose, and left ventricular systolic function in patients with primary percutaneous coronary intervention.
Topics: Aged; Clopidogrel; Echocardiography; Female; Humans; Leukocytes; Male; Middle Aged; Neutrophils; Percutaneous Coronary Intervention; Ticlopidine; Ventricular Function, Left | 2014 |
Images of an occlusive arterial disease of lower extremity due to chronic intoxication by ergot alkaloid.
Topics: Arterial Occlusive Diseases; Clopidogrel; Drug Substitution; Female; Humans; Lower Extremity; Methysergide; Middle Aged; Migraine Disorders; Oxazolidinones; Platelet Aggregation Inhibitors; Predictive Value of Tests; Serotonin 5-HT1 Receptor Agonists; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Tryptamines; Vasoconstrictor Agents | 2014 |
Age-related prevalence of diabetes mellitus, cardiovascular disease and anticoagulation therapy use in a urolithiasis population and their effect on outcomes: the Clinical Research Office of the Endourological Society Ureteroscopy Global Study.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Comorbidity; Coumarins; Diabetes Mellitus; Female; Humans; Hypertension; Kidney Calculi; Male; Middle Aged; Obesity; Platelet Aggregation Inhibitors; Postoperative Complications; Postoperative Hemorrhage; Prevalence; Prospective Studies; Risk Factors; Ticlopidine; Treatment Outcome; Ureteral Calculi; Ureteroscopy; Urolithiasis; Young Adult | 2015 |
Comparison of the effect of CYP2C19 polymorphism on clinical outcome between acute coronary syndrome and stable angina.
Topics: Acute Coronary Syndrome; Aged; Alleles; Angina, Stable; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Treatment Outcome | 2015 |
The significance of platelet count in traumatic brain injury patients on antiplatelet therapy.
Topics: Aged; Aspirin; Brain Injuries; Clopidogrel; Female; Humans; Intracranial Hemorrhages; Male; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; ROC Curve; Ticlopidine; Tomography, X-Ray Computed | 2014 |
Relationship between hyporesponsiveness to clopidogrel measured by thrombelastography and in stent restenosis in patients undergoing percutaneous coronary intervention.
Topics: Clopidogrel; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Risk Factors; Thrombelastography; Ticlopidine | 2014 |
Tailored antiplatelet therapy to improve prognosis in patients exhibiting clopidogrel low-response prior to percutaneous coronary intervention for stable angina or non-ST elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Angina, Stable; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Evidence of platelet sensitization to ADP following discontinuation of clopidogrel therapy in patients with stable coronary artery disease.
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2015 |
[Clinical impact of dual antiplatelet therapy on peptic ulcer disease].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Incidence; Male; Middle Aged; Peptic Ulcer; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2014 |
Effects of new regional cooperative rescue model on patients with ST-elevation myocardial infarction.
Topics: Aged; Aspirin; Clopidogrel; Electrocardiography; Emergency Medical Services; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Thrombolytic Therapy; Ticlopidine; Treatment Outcome | 2014 |
Aspirin treatment and outcomes after percutaneous coronary intervention: results of the ISAR-ASPI registry.
Topics: Aged; Aspirin; Biomarkers; Clopidogrel; Female; Humans; Incidence; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Proportional Hazards Models; Registries; Stents; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Aspirin treatment and outcomes in patients undergoing percutaneous coronary intervention: is there a role for pharmacodynamic testing?
Topics: Aspirin; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Ticlopidine | 2014 |
Clopidogrel prescription filling delays and cardiovascular outcomes in a pharmacy system integrating inpatient and outpatient care: insights from the Veterans Affairs CART Program.
Topics: Adult; Aged; Clopidogrel; Female; Hospitals, Veterans; Humans; Male; Middle Aged; Myocardial Infarction; Patient Compliance; Percutaneous Coronary Intervention; Pharmacy Service, Hospital; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; United States; United States Department of Veterans Affairs | 2014 |
Validation of acute myocardial infarction cases in the national health insurance research database in taiwan.
Topics: Aged; Aged, 80 and over; Aspirin; Clinical Coding; Clopidogrel; Cross-Sectional Studies; Databases, Factual; Female; Humans; Male; Middle Aged; Myocardial Infarction; National Health Programs; Platelet Aggregation Inhibitors; Reproducibility of Results; Taiwan; Ticlopidine | 2014 |
Genetic and non-genetic factors responsible for antiplatelet effects of clopidogrel in Japanese patients undergoing coronary stent implantation: an algorithm to predict on-clopidogrel platelet reactivity.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Asian People; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Stents; Ticlopidine | 2014 |
Reproducible complete remission of advanced hepatocellular carcinoma with sorafenib in combination with clopidogrel.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Humans; Liver Neoplasms; Male; Middle Aged; Niacinamide; Phenylurea Compounds; Platelet Aggregation Inhibitors; Receptors, Vascular Endothelial Growth Factor; Remission Induction; Sorafenib; Ticlopidine; Time Factors; Tomography, X-Ray Computed | 2014 |
Is personalized medicine a dream or a reality?
Topics: Clopidogrel; Drug Therapy; Genetic Variation; Genomics; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Pharmacokinetics; Precision Medicine; Tamoxifen; Ticlopidine; Warfarin | 2015 |
Prasugrel vs clopidogrel in cardiogenic shock patients undergoing primary PCI for acute myocardial infarction. Results of the ISAR-SHOCK registry.
Topics: Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Coronary Thrombosis; Female; Germany; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Recurrence; Registries; Risk Factors; Shock, Cardiogenic; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Impaired responsiveness to the platelet P2Y12 receptor antagonist clopidogrel in patients with type 2 diabetes and coronary artery disease.
Topics: Adult; Aged; Aspirin; Clopidogrel; Cohort Studies; Coronary Artery Disease; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Reference Values; Risk Assessment; Ticlopidine; Treatment Outcome | 2014 |
Diabetes mellitus and clopidogrel response variability.
Topics: Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Male; Platelet Aggregation; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2014 |
Time-related changes in determinants of antiplatelet effect of clopidogrel in patients after myocardial infarction.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Time Factors | 2014 |
Impact of clopidogrel plus aspirin versus aspirin alone on the progression of native coronary artery disease after bypass surgery: analysis from the Clopidogrel After Surgery for Coronary Artery DiseasE (CASCADE) randomized trial.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Coronary Restenosis; Coronary Stenosis; Diabetes Complications; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multicenter Studies as Topic; Platelet Aggregation Inhibitors; Postoperative Complications; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine | 2014 |
Bleeding complication with dual antiplatelet therapy: spontaneous uvula hematoma.
Topics: Aged, 80 and over; Aspirin; Clopidogrel; Coronary Disease; Drug Interactions; Hematoma; Humans; Laryngoscopy; Male; Metoprolol; Platelet Aggregation Inhibitors; Ticlopidine; Uvula | 2014 |
Variant recurrent risk among stroke patients with different CYP2C19 phenotypes and treated with clopidogrel.
Topics: Aged; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Recurrence; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2015 |
Changes in thrombus composition and profilin-1 release in acute myocardial infarction.
Topics: Analysis of Variance; Blood Platelets; Clopidogrel; Coronary Thrombosis; Female; Fibrinogen; Humans; Leukocytes; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Profilins; Thrombectomy; Thrombin; Ticlopidine; Time-to-Treatment | 2015 |
Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Biotransformation; Carboxylic Ester Hydrolases; Clopidogrel; Drug Interactions; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk; Ticlopidine | 2014 |
Intracranial hemorrhage during dual antiplatelet therapy after percutaneous left atrial appendage closure.
Topics: Aged; Aspirin; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Humans; Intracranial Hemorrhages; Male; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2014 |
CYP-independent inhibition of platelet aggregation in rabbits by a mixed disulfide conjugate of clopidogrel.
Topics: Animals; Biotransformation; Clopidogrel; Cytochrome P-450 Enzyme System; Disulfides; Humans; Injections, Intravenous; Kinetics; Male; Microsomes, Liver; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Rabbits; Recombinant Proteins; Ticlopidine | 2014 |
Assessment of the prophylactic role of aspirin and/or clopidogrel on experimentally induced acute myocardial infarction in hypercholesterolemic rats.
Topics: Animals; Aspirin; C-Reactive Protein; Cholesterol; Clopidogrel; Creatine Kinase; Diet, High-Fat; Drug Synergism; Drug Therapy, Combination; Hypercholesterolemia; Isoproterenol; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Rats; Serum Amyloid P-Component; Ticlopidine; Transforming Growth Factor beta1; Triglycerides | 2014 |
Impact of gene polymorphisms, platelet reactivity, and the SYNTAX score on 1-year clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention: the GEPRESS study.
Topics: Acute Coronary Syndrome; Aged; Biotransformation; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Phenotype; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Analysis of periinterventional complications of intracranial angioplasty and stenting: a single center experience.
Topics: Aged; Angioplasty; Aspirin; Blood Vessel Prosthesis Implantation; Clopidogrel; Diabetes Complications; Female; Humans; Hyperlipidemias; Hypertension; Intracranial Arteriosclerosis; Male; Middle Aged; Platelet Aggregation Inhibitors; Reperfusion Injury; Retrospective Studies; Stents; Stroke; Ticlopidine | 2014 |
Clopidogrel use as a risk factor for poor outcomes after kidney transplantation.
Topics: Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Graft Rejection; Graft Survival; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Period; Prognosis; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; Ticlopidine; Tissue Donors; Transplantation, Homologous; United States | 2014 |
The effect of clopidogrel on pharmacokinetics of ivabradine and its metabolite in rats.
Topics: Animals; Area Under Curve; Benzazepines; Cardiovascular Agents; Chromatography, High Pressure Liquid; Clopidogrel; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Half-Life; Ivabradine; Male; Mass Spectrometry; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ticlopidine | 2015 |
Prasugrel vs. clopidogrel in acute coronary syndrome patients treated with prasugrel.
Topics: Acute Coronary Syndrome; Aged; Bayes Theorem; Clopidogrel; Cohort Studies; Female; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Retrospective Studies; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats.
Topics: Animals; Apigenin; Area Under Curve; Clopidogrel; Erigeron; Glucuronates; Herb-Drug Interactions; Inhibitory Concentration 50; Male; Microsomes, Liver; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ticlopidine | 2015 |
How to optimize an individualized strategy for antiplatelet drug administration and discontinuation management using platelet function testing?
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine | 2014 |
Reply to the editor.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass, Off-Pump; Female; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine | 2014 |
Does baseline hematocrit influence the assays of on-treatment platelet reactivity to clopidogrel?
Topics: Aged; Blood Platelets; Clopidogrel; Elective Surgical Procedures; Female; Follow-Up Studies; Hematocrit; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Prospective Studies; Purinergic P2Y Receptor Antagonists; Reproducibility of Results; Stents; Ticlopidine; Treatment Outcome | 2014 |
2014 focused update of the Canadian Cardiovascular Society Guidelines for the management of atrial fibrillation.
Topics: Algorithms; Anticoagulants; Antithrombins; Aspirin; Atrial Fibrillation; Benzimidazoles; beta-Alanine; Canada; Clopidogrel; Comorbidity; Dabigatran; Electric Countershock; Humans; Renal Insufficiency, Chronic; Risk Assessment; Stroke; Ticlopidine | 2014 |
Comparison of a solid SMEDDS and solid dispersion for enhanced stability and bioavailability of clopidogrel napadisilate.
Topics: Animals; Clopidogrel; Drug Carriers; Drug Delivery Systems; Drug Stability; Emulsions; Male; Rats; Rats, Sprague-Dawley; Ticlopidine | 2014 |
Incidence of intracranial hemorrhage and outcomes after ground-level falls in geriatric trauma patients taking preinjury anticoagulants and antiplatelet agents.
Topics: Accidental Falls; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Female; Humans; Intracranial Hemorrhages; Logistic Models; Male; Multivariate Analysis; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Warfarin | 2014 |
Does clopidogrel with aspirin after acute minor stroke or transient ischemic attack increase the risk of cerebral hemorrhage?
Topics: Aspirin; Cerebral Hemorrhage; Clopidogrel; Humans; Ischemic Attack, Transient; Male; Middle Aged; Ticlopidine | 2014 |
Men with lower HDL cholesterol levels have significant increment of soluble CD40 ligand and high-sensitivity CRP levels following the cessation of long-term clopidogrel therapy.
Topics: Aged; C-Reactive Protein; CD40 Ligand; Cholesterol, HDL; Clopidogrel; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2015 |
Safety and efficacy of in-hospital clopidogrel-to-prasugrel switching in patients with acute coronary syndrome. An analysis from the 'real world'.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Substitution; Female; Hemorrhage; Humans; Male; Middle Aged; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Sex Factors; Thrombosis; Ticlopidine | 2015 |
Perioperative management of oral antiplatelet therapy and clinical outcomes in coronary stent patients undergoing surgery. Results of a multicentre registry.
Topics: Administration, Oral; Aged; Angina, Stable; Aspirin; Body Mass Index; Clopidogrel; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Ischemia; Odds Ratio; Percutaneous Coronary Intervention; Perioperative Period; Platelet Aggregation Inhibitors; Prevalence; Registries; Regression Analysis; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2015 |
Comparison of pharmacodynamics between low dose ticagrelor and clopidogrel after loading and maintenance doses in healthy Korean subjects.
Topics: Adenosine; Adult; Asian People; Blood Platelets; Clopidogrel; Female; Healthy Volunteers; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Republic of Korea; Ticagrelor; Ticlopidine; Young Adult | 2015 |
Precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet agent therapy.
Topics: Arachidonic Acid; Aspirin; Clopidogrel; Female; Healthy Volunteers; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reproducibility of Results; Sensitivity and Specificity; Ticlopidine | 2014 |
Evaluation of resistance to anti-platelet therapy in patients with coronary heart disease in a developing country.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Disease; Developing Countries; Drug Resistance; Hospitals, University; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Saudi Arabia; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Detection of clopidogrel resistance using ADP induced aggregometry with specific inhibitor PGE1.
Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Ticlopidine; Treatment Outcome | 2014 |
Contemporary use of dual antiplatelet therapy for preventing cardiovascular events.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Retrospective Studies; Risk Factors; Secondary Prevention; Ticlopidine | 2014 |
Anti-platelet agents augment cisplatin nanoparticle cytotoxicity by enhancing tumor vasculature permeability and drug delivery.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cisplatin; Clopidogrel; Drug Delivery Systems; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Nanospheres; Permeability; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Dendrimer-like assemblies based on organoclays as multi-host system for sustained drug delivery.
Topics: Bentonite; Cell Line; Cell Survival; Clopidogrel; Cyclodextrins; Delayed-Action Preparations; Dendrimers; Drug Carriers; Endothelial Cells; Humans; Microscopy, Electron, Transmission; Molecular Structure; Propylamines; Silanes; Spectroscopy, Fourier Transform Infrared; Surface Properties; Ticlopidine | 2014 |
Dental extractions and risk of bleeding in patients taking single and dual antiplatelet treatment.
Topics: Absorbable Implants; Aged; Aspirin; Clopidogrel; Collagen; Ecchymosis; Female; Hematoma; Hemostasis, Surgical; Hemostatic Techniques; Humans; Male; Middle Aged; Oral Hemorrhage; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prasugrel Hydrochloride; Prospective Studies; Risk Factors; Surgical Sponges; Suture Techniques; Ticlopidine; Time Factors; Tooth Extraction | 2015 |
Non-antiplatelet effect of clopidogrel: improving endothelial function in Chinese healthy subjects with different CYP2C19 genotype.
Topics: Adult; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Endothelium, Vascular; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Young Adult | 2015 |
Association of Medicare Part D low-income cost subsidy program enrollment with increased fill adherence to clopidogrel after coronary stent placement.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Databases, Factual; Female; Humans; Insurance Benefits; Male; Medicare Part D; Middle Aged; Outcome Assessment, Health Care; Patient Compliance; Pharmaceutical Services; Platelet Aggregation Inhibitors; Stents; Ticlopidine; United States | 2014 |
[Does dual antiplatelet therapy increase the risk of peptic ulcer disease?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Peptic Ulcer; Platelet Aggregation Inhibitors; Ticlopidine | 2014 |
Spontaneous coronary artery dissection: a complete resolution with medical treatment.
Topics: Adult; Aspirin; Clopidogrel; Coronary Angiography; Coronary Vessel Anomalies; Fibrinolytic Agents; Heparin, Low-Molecular-Weight; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Vascular Diseases | 2014 |
Relation between the Change in Mean Platelet Volume and Clopidogrel Resistance in Patients Undergoing Percutaneous Coronary Intervention.
Topics: Aged; Aspirin; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Mean Platelet Volume; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Retrospective Studies; Sensitivity and Specificity; Ticlopidine; Treatment Outcome | 2015 |
Adherence to antiplatelet therapy after percutaneous coronary intervention: a population study in a region of Italy.
Topics: Adult; Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Female; Humans; Italy; Longitudinal Studies; Male; Medication Adherence; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine | 2015 |
Clopidogrel: A multifaceted affair.
Topics: Aspirin; Biological Availability; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2015 |
Effects of cytochrome P450 2C19 and paraoxonase 1 polymorphisms on antiplatelet response to clopidogrel therapy in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aryldialkylphosphatase; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2014 |
Statistical Perspectives on Subgroup Analysis: Testing for Heterogeneity and Evaluating Error Rate for the Complementary Subgroup.
Topics: Algorithms; Antibiotics, Antineoplastic; Antineoplastic Agents; Aspirin; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Clopidogrel; Doxorubicin; Female; Humans; Ischemia; Ovarian Neoplasms; Platelet Aggregation Inhibitors; Reproducibility of Results; Research Design; Sample Size; Ticlopidine; Topotecan | 2015 |
Influence of race and sex on thrombogenicity in a large cohort of coronary artery disease patients.
Topics: Aged; Aspirin; Cardiac Catheterization; Chi-Square Distribution; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Platelet Aggregation; Platelet Function Tests; Racial Groups; Risk Assessment; Sex Factors; Thrombelastography; Thrombosis; Ticlopidine; Treatment Outcome | 2014 |
Platelet function assays--not all are created equal.
Topics: Aspirin; Clopidogrel; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2014 |
Very late bioresorbable vascular scaffold thrombosis following discontinuation of antiplatelet therapy.
Topics: Absorbable Implants; Adenosine; Adult; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Graft Occlusion, Vascular; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Stents; Ticagrelor; Ticlopidine; Tirofiban; Tissue Scaffolds; Tyrosine | 2015 |
[Lateral medullary infarction presenting with truncal lateropulsion and decreased pain and temperature sensation below T10 sensory level].
Topics: Antipyrine; Arginine; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Edaravone; Free Radical Scavengers; Humans; Lateral Medullary Syndrome; Magnetic Resonance Imaging; Male; Medulla Oblongata; Middle Aged; Pipecolic Acids; Platelet Aggregation Inhibitors; Somatosensory Disorders; Sulfonamides; Ticlopidine; Treatment Outcome; Vertebral Artery Dissection | 2014 |
Association of plasma miR-223 and platelet reactivity in patients with coronary artery disease on dual antiplatelet therapy: A preliminary report.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; MicroRNAs; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2015 |
Dipstick proteinuria is an independent predictor of high on treatment platelet reactivity in patients on clopidogrel, but not aspirin, admitted for major adverse cardiovascular events.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Odds Ratio; Patient Admission; Patient Outcome Assessment; Platelet Function Tests; Proteinuria; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2015 |
Individualising dual antiplatelet therapy after percutaneous coronary intervention: the IDEAL-PCI registry.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Coronary Artery Disease; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Prospective Studies; Registries; Stents; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
Outcome of patients on oral anticoagulation undergoing coronary artery stenting: data from discharge to 12 months in the Warfarin and Coronary Stenting (WAR-STENT) Registry.
Topics: Administration, Oral; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Databases, Bibliographic; Drug Therapy, Combination; Drug-Eluting Stents; Follow-Up Studies; Hemorrhage; Prospective Studies; Registries; Ticlopidine; Treatment Outcome; Warfarin | 2014 |
No benefit to prolonged dual antiplatelet therapy after drug-eluting stent placement.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2014 |
Influence of dual antiplatelet therapy on mean platelet volume in patients with coronary artery disease undergoing percutaneous coronary intervention.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Monitoring; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Mean Platelet Volume; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Kounis syndrome secondary to food allergy.
Topics: Acute Coronary Syndrome; Adrenal Cortex Hormones; Anti-Allergic Agents; Aspirin; Clopidogrel; Electrocardiography; Female; Fibrinolytic Agents; Food Hypersensitivity; Heparin, Low-Molecular-Weight; Humans; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Urticaria | 2014 |
Optimising pharmacotherapy for secondary prevention of non-invasively managed acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Thrombosis; Fibrinolytic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Secondary Prevention; Ticlopidine | 2014 |
Solid-state NMR as an effective method of polymorphic analysis: solid dosage forms of clopidogrel hydrogensulfate.
Topics: Chemistry, Pharmaceutical; Clopidogrel; Counterfeit Drugs; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Platelet Aggregation Inhibitors; Poland; Purinergic P2Y Receptor Antagonists; Quality Control; Quantum Theory; Sulfates; Tablets; Ticlopidine; Wavelet Analysis | 2015 |
Roles of the red cell distribution width and neutrophil/lymphocyte ratio in predicting thrombolysis failure in patients with an ST-segment elevation myocardial infarction.
Topics: Aged; Aspirin; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Electrocardiography; Erythrocyte Indices; Female; Fibrinolytic Agents; Humans; Leukocyte Count; Lymphocyte Count; Male; Middle Aged; Myocardial Infarction; Neutrophils; Percutaneous Coronary Intervention; Prognosis; Retrospective Studies; ROC Curve; Salvage Therapy; Sensitivity and Specificity; Tenecteplase; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator; Treatment Failure | 2015 |
Dual antiplatelet therapy after drug-eluting stents--how long to treat?
Topics: Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Thrombosis; Ticlopidine | 2014 |
Stent thrombosis is the primary cause of ST-segment elevation myocardial infarction following coronary stent implantation: a five year follow-up of the SORT OUT II study.
Topics: Aged; Angina, Stable; Clopidogrel; Cohort Studies; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2014 |
Tailored antiplatelet therapy in a patient with ITP and clopidogrel resistance.
Topics: Adenosine; Clopidogrel; Coronary Thrombosis; Drug Resistance; Drug Substitution; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purpura, Thrombocytopenic, Idiopathic; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Impact of common ABCB1 polymorphism on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites.
Topics: Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Female; Genotype; Half-Life; Humans; Male; Metabolic Clearance Rate; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Tandem Mass Spectrometry; Ticlopidine | 2015 |
Should clopidogrel be discontinued before laparoscopic cholecystectomy?
Topics: Adult; Aged; Aged, 80 and over; Blood Loss, Surgical; Cholecystectomy, Laparoscopic; Clopidogrel; Female; Humans; Length of Stay; Male; Middle Aged; Morbidity; Operative Time; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Ticlopidine; Treatment Outcome | 2014 |
A patient who received clopidogrel with an indwelling epidural catheter.
Topics: Aged, 80 and over; Analgesia, Epidural; Catheters, Indwelling; Clopidogrel; Device Removal; Drug-Eluting Stents; Female; Humans; Pain, Postoperative; Platelet Aggregation Inhibitors; Platelet Transfusion; Postoperative Care; Thoracotomy; Ticlopidine | 2014 |
Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition.
Topics: Animals; Bleeding Time; Blood Coagulation; Blood Platelets; Clopidogrel; Disease Models, Animal; Factor IX; Fibrin; Hemostasis; Intravital Microscopy; Laser Therapy; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Microscopy, Video; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Saphenous Vein; Talin; Thromboplastin; Ticlopidine; Time Factors; Vascular System Injuries | 2015 |
A new mechanism of action of thienopyridine antiplatelet drugs - a role for gastric nitrosthiol metabolism?
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Models, Biological; Nitrates; Nitric Oxide; Nitrogen; Oxygen; Platelet Aggregation Inhibitors; Pyridines; Receptors, Purinergic P2Y12; S-Nitrosothiols; Sulfhydryl Compounds; Ticlopidine | 2014 |
Right here waiting...?
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Artery Bypass; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine | 2014 |
Impact of C34T P2Y12 genotype on endothelial function and arterial stiffness in patients after percutaneous coronary intervention receiving clopidogrel.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Endothelium, Vascular; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Outcome; Vascular Stiffness | 2014 |
Blood pressure control after stroke: too little, too late, or too soon to tell?
Topics: Aspirin; Blood Pressure; Clopidogrel; Cognition; Female; Humans; Male; Platelet Aggregation Inhibitors; Stroke, Lacunar; Ticlopidine | 2014 |
VASP phosphorylation and genetic polymorphism for clopidogrel resistance in Chinese patients with non-cardioembolic ischemic stroke.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Ischemia; Cell Adhesion Molecules; China; Clopidogrel; Drug Resistance; Female; Genetic Markers; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prevalence; Reproducibility of Results; Risk Factors; Sensitivity and Specificity; Stroke; Ticlopidine; Treatment Failure; Young Adult | 2014 |
Impact of diabetes mellitus and metabolic syndrome on acute and chronic on-clopidogrel platelet reactivity in patients with stable coronary artery disease undergoing drug-eluting stent placement.
Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Coronary Artery Disease; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Monitoring; Drug-Eluting Stents; Female; France; Humans; Israel; Male; Metabolic Syndrome; Middle Aged; Odds Ratio; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Prospective Studies; Ticlopidine | 2014 |
A constrained heart: a case of sudden onset unrelenting chest pain.
Topics: Analgesics, Opioid; Aspirin; Chest Pain; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Echocardiography; Electrocardiography; Heart Defects, Congenital; Humans; Male; Middle Aged; Morphine; Nitroglycerin; Pericardium; Platelet Aggregation Inhibitors; Ticlopidine; Tomography, X-Ray Computed; Vasodilator Agents | 2014 |
Joint effects of CYP2C19*2 and smoking status on clopidogrel responsiveness in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Smoking; Ticlopidine | 2015 |
Impact of cytochrome P450 2C19 loss-of-function polymorphism on intra-stent thrombi and lesion outcome after everolimus-eluting stent implantation compared to that after first-generation drug-eluting stent implantation.
Topics: Aged; Clopidogrel; Coronary Angiography; Cytochrome P-450 Enzyme System; Drug-Eluting Stents; Everolimus; Female; Genotype; Humans; Immunosuppressive Agents; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Sirolimus; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2015 |
Concomitant use of warfarin and ticagrelor as an alternative to triple antithrombotic therapy after an acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Aspirin; Atrial Fibrillation; Clopidogrel; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome; Warfarin | 2015 |
Intrastent thrombus – what you see is what you get?
Topics: Angioscopy; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Humans; Male; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2015 |
Influence of CYP2C19 polymorphisms on platelet reactivity and clinical outcomes in ischemic stroke patients treated with clopidogrel.
Topics: Aged; Blood Platelets; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prognosis; Stroke; Ticlopidine; Treatment Outcome | 2015 |
Endovascular treatment of internal carotid artery pseudo-aneurysm presenting with epistaxis. A case report.
Topics: Angiography, Digital Subtraction; Aspirin; Carotid Artery Injuries; Carotid Artery, Internal; Clopidogrel; Endovascular Procedures; Epistaxis; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Stents; Ticlopidine; Treatment Outcome | 2014 |
Unusual cause of aborted sudden cardiac death in a teen athlete: homozygosity for the 4G allele of the plasminogen activase inhibitor type 1 gene.
Topics: Adolescent; Alleles; Aspirin; Athletes; Cardiac Catheterization; Clopidogrel; Death, Sudden, Cardiac; Homozygote; Humans; Male; Plasminogen Activator Inhibitor 1; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
High platelet reactivity is associated with vascular function in patients after percutaneous coronary intervention receiving clopidogrel.
Topics: Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Period; Prospective Studies; Ticlopidine | 2014 |
Patterns of Antiplatelet Therapy in Patients Who Have Experienced an Acute Coronary Event: A Descriptive Study in UK Primary Care.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Primary Health Care; Proton Pump Inhibitors; Retrospective Studies; Secondary Prevention; Stroke; Ticlopidine; United Kingdom | 2015 |
Point-of-care platelet reactivity determination with VerifyNow-P2Y12 following administration of clopidogrel or prasugrel: data from a real-world, clinical care inpatient setting.
Topics: Aged; Clopidogrel; Electronic Health Records; Female; Hospitalization; Hospitals, Urban; Humans; Logistic Models; Male; Medical Audit; Middle Aged; Piperazines; Platelet Aggregation; Point-of-Care Systems; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine | 2014 |
Assessment of risk of late rectal bleeding for patients with prostate cancer started on anticoagulation before or after radiation treatment.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Prostatic Neoplasms; Radiation Injuries; Radiotherapy, Conformal; Radiotherapy, Intensity-Modulated; Rectum; Retrospective Studies; Risk; Telangiectasis; Ticlopidine; Warfarin | 2014 |
Web Exclusives. The consult guys--balancing the medication portfolio 5 years after a heart attack.
Topics: Adrenergic beta-1 Receptor Antagonists; Aspirin; Clopidogrel; Drug Therapy, Combination; Evidence-Based Medicine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Metoprolol; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2014 |
In-hospital switching between adenosine diphosphate receptor inhibitors in patients with acute myocardial infarction treated with percutaneous coronary intervention: Insights into contemporary practice from the TRANSLATE-ACS study.
Topics: Adenosine; Aged; Clopidogrel; Drug Substitution; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Patient Discharge; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
A pharmacodynamic comparison of 5 anti-platelet protocols in patients with ST-elevation myocardial infarction undergoing primary PCI.
Topics: Adenosine; Aged; Blood Platelets; Clinical Protocols; Clopidogrel; Drug Administration Schedule; Electrocardiography; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Thiophenes; Ticagrelor; Ticlopidine | 2014 |
[Effect of original and generic clopidogrel on prognosis in relation to different gene polymorphisms].
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Monitoring; Drug Resistance; Drug Substitution; Drugs, Generic; Female; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Prognosis; Therapeutic Equivalency; Ticlopidine; Treatment Outcome | 2014 |
[Factors influencing platelet aggregation in patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Aspirin; Blood Coagulation Tests; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Monitoring; Female; Humans; Male; Mean Platelet Volume; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Statistics as Topic; Ticlopidine; Time Factors | 2014 |
Effect of rebamipide on gastric bleeding and ulcerogenic responses induced by aspirin plus clopidogrel under stimulation of acid secretion in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Disease Models, Animal; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Male; Platelet Aggregation Inhibitors; Quinolones; Rats, Sprague-Dawley; Stomach Ulcer; Ticlopidine; Treatment Outcome | 2014 |
From innovation to implementation: optimizing long-term outcomes after TAVR.
Topics: Aortic Valve Stenosis; Aspirin; Clopidogrel; Female; Hemorrhage; Humans; Male; Ticlopidine; Transcatheter Aortic Valve Replacement | 2014 |
CYP2C19 genotype and early ischemic lesion recurrence in stroke patients treated with clopidogrel.
Topics: Aged; Asian People; Brain; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Diffusion Magnetic Resonance Imaging; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2015 |
[Analysis of traditional Chinese medicine syndrome, traditional Chinese medicine and western medicine in 84 697 patients with coronary heart disease based on big data].
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Disease; Drugs, Chinese Herbal; Female; Humans; Isosorbide Dinitrate; Male; Medicine, Chinese Traditional; Middle Aged; Ticlopidine | 2014 |
Hematospermia due to clopidogrel: the unknown side effect.
Topics: Clopidogrel; Hemospermia; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Aspirin is associated with an increased risk of subdural hematoma in normal-pressure hydrocephalus patients following shunt implantation.
Topics: Aged; Aged, 80 and over; Aspirin; Cerebrospinal Fluid Shunts; Clopidogrel; Female; Fibrinolytic Agents; Hematoma, Subdural; Humans; Hydrocephalus, Normal Pressure; Male; Middle Aged; Risk Factors; Ticlopidine | 2015 |
[Clopidogrel resistance in cerebrovascular disease -- results of one-year follow-up].
Topics: Adult; Aged; Blood Glucose; Blood Pressure; C-Reactive Protein; Clopidogrel; Drug Resistance; Female; Follow-Up Studies; Humans; Ischemic Attack, Transient; Lipids; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
[Population pharmacokinetics and pharmacodynamics of clopidogrel in patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Polymorphism, Genetic; Ticlopidine | 2014 |
Spontaneous renal parenchymal hematoma associated with clopidogrel in a patient with diabetic nephropathy.
Topics: Aged; Clopidogrel; Diabetic Nephropathies; Hematoma; Humans; Kidney Diseases; Male; Platelet Aggregation Inhibitors; Renal Dialysis; Retroperitoneal Space; Ticlopidine | 2015 |
Use of a quantitative platelet function test to guide epidural catheter removal in a patient who inadvertently received clopidogrel.
Topics: Analgesia, Epidural; Anesthesia, Epidural; Catheterization; Catheters; Clopidogrel; Humans; Male; Medication Errors; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2015 |
Discrepancies in assessment of adherence to antiplatelet treatment after myocardial infarction.
Topics: Adenosine Diphosphate; Clopidogrel; Female; Humans; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2015 |
World heart federation expert consensus statement on antiplatelet therapy in east asian patients with ACS or undergoing PCI.
Topics: Acute Coronary Syndrome; Adenosine; Asia, Eastern; Cardiology; Clopidogrel; Humans; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Societies, Medical; Thiophenes; Ticagrelor; Ticlopidine; World Health Organization | 2014 |
The relationship between on-clopidogrel platelet reactivity, genotype, and post-percutaneous coronary intervention outcomes in Chinese patients.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; China; Clopidogrel; Combined Modality Therapy; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2015 |
Liquid Chromatographic Method for Simultaneous Quantitation of Clopidogrel, Aspirin and Atorvastatin in Rat Plasma and Its Application to the Pharmacokinetic Study.
Topics: Animals; Anticholesteremic Agents; Aspirin; Atorvastatin; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Clopidogrel; Limit of Detection; Male; Platelet Aggregation Inhibitors; Rats; Reproducibility of Results; Ticlopidine | 2015 |
[Changes in the diagnosis and treatment of hospitalized patients with acute coronary syndrome from 2006 to 2012 in China].
Topics: Acute Coronary Syndrome; Aged; Aspirin; Cardiovascular Diseases; China; Clopidogrel; Female; Hospitalization; Hospitals; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Ticlopidine | 2014 |
Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia.
Topics: Animals; Antithrombin III; Clopidogrel; Cytokines; Disease Models, Animal; Mice; Peptide Hydrolases; Pneumonia, Pneumococcal; Purinergic P2Y Receptor Antagonists; Streptococcus pneumoniae; Thrombocytopenia; Ticlopidine | 2015 |
Routine screening for CYP2C19 polymorphisms for patients being treated with clopidogrel is not recommended.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Hawaii; Humans; Mass Screening; Polymorphism, Genetic; Ticlopidine | 2015 |
Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy.
Topics: Aged; Case-Control Studies; Clopidogrel; Female; Humans; Male; Middle Aged; Oral Surgical Procedures; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Factors; Ticlopidine | 2015 |
Balancing the risks of bleeding and stent thrombosis: a decision analytic model to compare durations of dual antiplatelet therapy after drug-eluting stents.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Decision Support Techniques; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Markov Chains; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Adjustment; Risk Assessment; Thrombosis; Ticlopidine; Time; Treatment Outcome | 2015 |
High on-treatment platelet reactivity in transcatheter aortic valve implantation patients.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Ischemia; Male; Platelet Aggregation Inhibitors; Ticlopidine; Transcatheter Aortic Valve Replacement | 2015 |
The effect of clopidogrel on platelet activity in patients with and without type-2 diabetes mellitus: a comparative study.
Topics: Aged; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2015 |
Response to dual antiplatelet therapy in patients with peripheral artery occlusive disease suffering from critical limb ischemia.
Topics: Aged; Aged, 80 and over; Area Under Curve; Aspirin; Clopidogrel; Critical Illness; Drug Resistance; Drug Therapy, Combination; Female; Germany; Humans; Ischemia; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; ROC Curve; Ticlopidine; Time Factors; Treatment Outcome | 2014 |
Point-of-care platelet function testing predicts bleeding in patients exposed to clopidogrel undergoing coronary artery bypass grafting: Verify pre-op TIMI 45--a pilot study.
Topics: Aged; Area Under Curve; Blood Platelets; Clopidogrel; Coronary Artery Bypass; Drug Resistance; Female; Hemorrhage; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; ROC Curve; Ticlopidine; Treatment Outcome; United States | 2015 |
Comparative risk of ischemic stroke among users of clopidogrel together with individual proton pump inhibitors.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Brain Ischemia; Clopidogrel; Data Interpretation, Statistical; Drug Therapy, Combination; Esomeprazole; Female; Humans; Lansoprazole; Male; Middle Aged; Omeprazole; Pantoprazole; Proportional Hazards Models; Proton Pump Inhibitors; Rabeprazole; Retrospective Studies; Risk; Stroke; Ticlopidine | 2015 |
Acute coronary syndromes and coronary intervention.
Topics: Angina, Unstable; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2015 |
A delicate balance: the cost effectiveness of new antiplatelet agents.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Female; Humans; Male; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2015 |
An idiosyncratic reaction to clopidogrel.
Topics: Aged; Chemical and Drug Induced Liver Injury; Clopidogrel; Female; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Vomiting | 2015 |
Biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent in patients with acute myocardial infarction.
Topics: Absorbable Implants; Aged; Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Everolimus; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Prospective Studies; Prosthesis Design; Sirolimus; Ticlopidine; Treatment Outcome | 2015 |
Optimal cutoff value of P2Y12 reaction units to prevent major adverse cardiovascular events in the acute periprocedural period: post-hoc analysis of the randomized PRASFIT-ACS study.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Preoperative Care; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; ROC Curve; Ticlopidine | 2015 |
Serial changes of mean platelet volume in relation to Killip Class in patients with acute myocardial infarction and primary percutaneous coronary intervention.
Topics: Acute Disease; Clopidogrel; Echocardiography; Female; Humans; Male; Mean Platelet Volume; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine | 2015 |
Dual antiplatelet therapy in patients with a long coronary artery lesion over 30 mm: Determinants and impact on prognosis.
Topics: Administration, Inhalation; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Linear Models; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Sellar and parasellar tumor removal without discontinuing antithrombotic therapy.
Topics: Adenoma; Aged; Aspirin; Central Nervous System Cysts; Clopidogrel; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Neurosurgical Procedures; Pituitary Neoplasms; Postoperative Period; Ticlopidine; Treatment Outcome | 2015 |
Effect of proton-pump inhibitors on the risk of lower gastrointestinal bleeding associated with NSAIDs, aspirin, clopidogrel, and warfarin.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Aspirin; Case-Control Studies; Clopidogrel; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Ticlopidine; Warfarin; Young Adult | 2015 |
How should I treat subacute stent thrombosis in the context of brain haemorrhage with abciximab?
Topics: Abciximab; Antibodies, Monoclonal; Aspirin; Cerebral Hemorrhage; Clopidogrel; Embolic Protection Devices; Female; Humans; Immunoglobulin Fab Fragments; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Suction; Thrombosis; Ticlopidine | 2015 |
New approach application of data transformation in mean centering of ratio spectra method.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Atorvastatin; Clopidogrel; Normal Distribution; Platelet Aggregation Inhibitors; Spectrophotometry; Ticlopidine | 2015 |
Thrombotic complications associated with early and late nonadherence to dual antiplatelet therapy.
Topics: Aged; Aspirin; Cardiovascular Agents; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Medication Adherence; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Prosthesis Design; Registries; Risk Factors; Sirolimus; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans.
Topics: Adult; Carboxylic Ester Hydrolases; Clopidogrel; Female; Genotype; Humans; Hydrolysis; Male; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2015 |
RASA3 is a critical inhibitor of RAP1-dependent platelet activation.
Topics: Animals; Cellular Senescence; Clopidogrel; GTPase-Activating Proteins; Guanine Nucleotide Exchange Factors; Hemostasis; Lymphopenia; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Platelet Activation; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-akt; rap1 GTP-Binding Proteins; Receptors, Purinergic P2Y12; Saphenous Vein; Splenectomy; Thrombocytopenia; Thrombopoiesis; Ticlopidine | 2015 |
Preinjury warfarin, but not antiplatelet medications, increases mortality in elderly traumatic brain injury patients.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Brain Injuries; Clopidogrel; Female; Humans; Intracranial Hemorrhages; Length of Stay; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Survival Rate; Ticlopidine; Tomography, X-Ray Computed; Trauma Severity Indices; Warfarin | 2015 |
Effect of clinical factors and gene polymorphism of CYP2C19*2, *17 and CYP4F2*3 on early stent thrombosis.
Topics: Aged; Aspirin; Case-Control Studies; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Female; Genotype; Humans; Logistic Models; Male; Middle Aged; Models, Genetic; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Stents; Thrombosis; Ticlopidine | 2015 |
Dual Antiplatelet Therapy Duration Following Coronary Stenting. [Corrected].
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Percutaneous Coronary Intervention; Ticlopidine | 2015 |
Stent selection and antiplatelet therapy duration: one size does not fit all.
Topics: Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Percutaneous Coronary Intervention; Postoperative Complications; Sirolimus; Ticlopidine | 2015 |
Actively using clopidogrel correlates with an increased risk of acute pancreatitis in Taiwan.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Female; Humans; Male; Middle Aged; Pancreatitis; Platelet Aggregation Inhibitors; Risk; Taiwan; Ticlopidine; Young Adult | 2015 |
Prognostic impact of clopidogrel pretreatment in patients with acute coronary syndrome managed invasively.
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Percutaneous Coronary Intervention; Preoperative Care; Prognosis; Purinergic P2Y Receptor Antagonists; Registries; Retrospective Studies; Spain; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Diversity of platelet function and genetic polymorphism in clopidogrel-treated Chinese patients.
Topics: Adenosine Diphosphate; Adult; Aged; Alleles; Blood Coagulation; Blood Platelets; China; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Female; Genotype; Humans; Ischemia; Logistic Models; Male; Middle Aged; Mutation; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Receptors, Purinergic P2Y12; Recurrence; Thrombelastography; Ticlopidine | 2015 |
Inhibition of platelet function with clopidogrel, as measured with a novel whole blood impedance aggregometer in horses.
Topics: Animals; Blood Coagulation Tests; Blood Platelets; Clopidogrel; Female; Horses; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2015 |
Plasma fibrin clot phenotype independently affects intracoronary thrombus ultrastructure in patients with acute myocardial infarction.
Topics: Aged; Aspirin; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Coronary Vessels; Drug Therapy, Combination; Erythrocytes; Female; Fibrin; Fibrinolysis; Humans; Male; Microscopy, Electron, Scanning; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Permeability; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Porosity; Suction; Thrombectomy; Ticlopidine; Time Factors | 2015 |
Comment: TIA response to antiplatelets stratified by glycated albumin.
Topics: Aspirin; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Male; Stroke; Ticlopidine | 2015 |
[Paroxysmal atrial fibrillation well controlled. Why the sudden patient syncope?].
Topics: Amiodarone; Atrial Fibrillation; Clopidogrel; Coronary Disease; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Humans; Long QT Syndrome; Male; Middle Aged; Risk Factors; Syncope; Ticlopidine; Torsades de Pointes | 2015 |
[Triple anticoagulant therapy - now what can I give for pain?].
Topics: Aged; Analgesics; Anticoagulants; Aspirin; Back Pain; Benzimidazoles; beta-Alanine; Clopidogrel; Contraindications; Dabigatran; Drug Therapy, Combination; Germany; Hemorrhage; Humans; Male; Risk Factors; Stents; Ticlopidine | 2015 |
Investigation of possible prophylactic, renoprotective, and cardioprotective effects of thromboprophylactic drugs against ischemia-reperfusion injury.
Topics: Animals; Anticoagulants; Aryldialkylphosphatase; Aspirin; Cardiotonic Agents; Clopidogrel; Dipeptidases; Drug Evaluation, Preclinical; Enoxaparin; Femoral Artery; Heparin, Low-Molecular-Weight; Hindlimb; Kidney; Male; Malondialdehyde; Morpholines; Myocardium; Nitric Oxide; Oxidative Stress; Rats, Sprague-Dawley; Reperfusion Injury; Rivaroxaban; Thiophenes; Ticlopidine | 2015 |
Characterization of patients with angioscopically-detected in-stent mural thrombi – genetics of clopidogrel responsiveness and generations of drug-eluting stents.
Topics: Activation, Metabolic; Aged; Alleles; Angina Pectoris; Angioscopy; Aspirin; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Proton Pump Inhibitors; Receptors, Purinergic P2Y12; Ticlopidine | 2015 |
Dual antiplatelet response during PCI: VerifyNow P2Y12 predicts myocardial necrosis and thromboxane B2 generation confirms wide variation in aspirin response.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Myocardium; Necrosis; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Purinergic P2Y12; Regression Analysis; Thromboxane B2; Ticlopidine | 2015 |
Carboxylesterase 1-mediated drug-drug interactions between clopidogrel and simvastatin.
Topics: Carboxylic Ester Hydrolases; Clopidogrel; Drug Interactions; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Simvastatin; Ticlopidine | 2015 |
[Determination of clopidogrel sulfate in pharmaceutical formulation and biological fluids by extraction spectrofluorimetric method].
Topics: Body Fluids; Calibration; Clopidogrel; Fluorescence; Humans; Spectrometry, Fluorescence; Tablets; Ticlopidine | 2014 |
Angiographic and clinical results of everolimus-eluting stent utilization in saphenous vein graft lesions (ARES).
Topics: Aged; Aged, 80 and over; Angiography; Angioplasty, Balloon; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Disease; Drug-Eluting Stents; Everolimus; Female; Graft Occlusion, Vascular; Humans; Male; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Reoperation; Saphenous Vein; Ticlopidine | 2015 |
A multidisciplinary approach in early stent thrombosis: Insights from optical coherence tomography and platelet reactivity testing.
Topics: Aged; Angioplasty, Balloon, Coronary; Anterior Wall Myocardial Infarction; Clopidogrel; Coronary Restenosis; Drug Resistance; Drug Substitution; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Stents; Thrombectomy; Ticlopidine; Time Factors; Tomography, Optical Coherence; Treatment Outcome; Vascular Patency | 2015 |
Clinical impact of dual antiplatelet therapy use in patients following everolimus-eluting stent implantation: insights from the SEEDS study.
Topics: Adolescent; Adult; Aged; Aspirin; Clopidogrel; Drug-Eluting Stents; Everolimus; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Sirolimus; Thrombosis; Ticlopidine; Treatment Outcome; Young Adult | 2015 |
Comparing of light transmittance aggregometry and modified thrombelastograph in predicting clinical outcomes in Chinese patients undergoing coronary stenting with clopidogrel.
Topics: Aged; Asian People; Clopidogrel; Female; Humans; Linear Models; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2015 |
Predictors of high on-aspirin platelet reactivity in high-risk vascular patients treated with single or dual antiplatelet therapy.
Topics: Adenosine; Aged; Aspirin; Cerebrovascular Disorders; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Fibrinogen; Humans; Male; Middle Aged; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Secondary Prevention; Thiophenes; Ticagrelor; Ticlopidine | 2015 |
Clopidogrel reduces apoptosis and promotes proliferation of human vascular endothelial cells induced by palmitic acid via suppression of the long non-coding RNA HIF1A-AS1 in vitro.
Topics: Apoptosis; Cardiovascular Diseases; Cell Proliferation; China; Clopidogrel; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Palmitic Acid; RNA, Antisense; RNA, Long Noncoding; RNA, Small Interfering; Ticlopidine | 2015 |
Evaluating the bioequivalence of clopidogrel generic formulations.
Topics: Chemistry, Pharmaceutical; Clopidogrel; Drugs, Generic; Humans; Platelet Aggregation Inhibitors; Therapeutic Equivalency; Ticlopidine | 2015 |
Heparin resistance and coagulation activation rebound effect after anticoagulant withdrawal: beneficiary effect of adjuvant antiplatelet therapy.
Topics: Aged; Anticoagulants; Arthroplasty, Replacement, Hip; Blood Coagulation; Case-Control Studies; Clopidogrel; Drug Resistance; Enoxaparin; Female; France; Heparin; Humans; Male; Middle Aged; Thromboembolism; Ticlopidine | 2016 |
Complications of transbrachial arterial access for peripheral endovascular interventions.
Topics: Adult; Aged; Aged, 80 and over; Brachial Artery; Catheterization, Peripheral; Clopidogrel; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Prospective Studies; Punctures; Risk Factors; Ticlopidine; Treatment Outcome; Ultrasonography | 2015 |
Bare metal stents for treatment of extracranial internal carotid artery aneurysms: long-term results.
Topics: Adult; Aged; Aneurysm; Carotid Artery, Internal; Clopidogrel; Endovascular Procedures; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Metals; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2015 |
Clopidogrel reduces the inflammatory response of lung in a rat model of decompression sickness.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Clopidogrel; Cytokines; Decompression Sickness; Disease Models, Animal; Immunohistochemistry; Leukocytes; Lung; Male; Organ Size; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Pressure; Rats, Sprague-Dawley; Ticlopidine; Treatment Outcome | 2015 |
Cilostazol may prevent cardioembolic stroke in patients undergoing antiplatelet therapy.
Topics: Aged; Aspirin; Atrial Fibrillation; Cilostazol; Clopidogrel; Databases, Factual; Female; Fibrinolytic Agents; Humans; Incidence; Intracranial Embolism; Male; Multivariate Analysis; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Tetrazoles; Ticlopidine | 2015 |
Prevalence of CYP2C19 alleles, pharmacokinetic and pharmacodynamic variation of clopidogrel and prasugrel in Bangladeshi population.
Topics: Bangladesh; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Ticlopidine | 2015 |
Impact of cytochrome P450 2C19*2 polymorphism on intra-stent thrombus assessed by follow-up optical coherence tomography in Chinese patients receiving clopidogrel.
Topics: Aged; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Retrospective Studies; Stents; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2015 |
Synthesis of the alkylated active metabolite of tipidogrel.
Topics: Alkylation; Animals; Chromatography, High Pressure Liquid; Clopidogrel; Half-Life; Piperidines; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2Y12; Tandem Mass Spectrometry; Thiophenes; Ticlopidine | 2015 |
Effects of Paclitaxel on the Ability of Aspirin and Clopidogrel to Inhibit Platelet Aggregation.
Topics: Adenosine Diphosphate; Adult; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Male; Paclitaxel; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2016 |
Does the response to aspirin and clopidogrel vary over 6 months in patients with ischemic heart disease?
Topics: Aged; Area Under Curve; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Drug Therapy, Combination; England; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Receptors, Purinergic P2Y12; Reproducibility of Results; ROC Curve; Thrombelastography; Thromboxane B2; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Influence of CYP2C19 loss-of-function variants on the metabolism of clopidogrel in patients from north-western China.
Topics: Aged; Asian People; China; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Ticlopidine | 2015 |
Potential for a Significant Interaction Between Clopidogrel and Dasabuvir.
Topics: 2-Naphthylamine; Antiviral Agents; Clopidogrel; Drug Interactions; Enzyme Inhibitors; Hepatitis C, Chronic; Humans; Sulfonamides; Ticlopidine; Torsades de Pointes; Uracil | 2015 |
Effect of Active Smoking on Comparative Efficacy of Antithrombotic Therapy in Patients With Atrial Fibrillation: The Loire Valley Atrial Fibrillation Project.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Case-Control Studies; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proportional Hazards Models; Smoking; Stroke; Thromboembolism; Ticlopidine; Warfarin | 2015 |
Removal of Special Authority requirements for clopidogrel improved optimal care following percutaneous coronary intervention across sociodemographic groups.
Topics: Adult; Aged; Clopidogrel; Drug and Narcotic Control; Ethnicity; Female; Health Services Accessibility; Healthcare Disparities; Humans; Male; Middle Aged; New Zealand; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Socioeconomic Factors; Ticlopidine | 2015 |
CYP2C19*2 genotype influence in acute coronary syndrome patients undergoing serial clopidogrel dose tailoring based on platelet function testing: Analysis from randomized controlled trial NCT02096419.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2015 |
In-vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: experience with miconazole and clopidogrel salts.
Topics: Administration, Oral; Capsules; Chlorides; Clopidogrel; Drug Carriers; Drug Compounding; Duodenum; Fasting; Gastric Juice; Gelatin; Hardness; Hydrogen-Ion Concentration; Intestinal Secretions; Miconazole; Models, Chemical; Nitrates; Solubility; Stomach; Sulfates; Ticlopidine; Time Factors | 2016 |
Aspirin 'resistance': impact on no-reflow, platelet and inflammatory biomarkers in diabetics after ST-segment elevation myocardial infarction.
Topics: Aged; Aspirin; Biomarkers; Clopidogrel; Diabetes Complications; Drug Resistance; Female; Humans; Inflammation; Male; Middle Aged; Myocardial Infarction; No-Reflow Phenomenon; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Platelets are relevant mediators of renal injury induced by primary endothelial lesions.
Topics: Acute Kidney Injury; Animals; Blood Platelets; Cell-Derived Microparticles; Clopidogrel; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Male; Mice, Inbred C57BL; P-Selectin; Platelet Activation; Ticlopidine | 2015 |
Efficacy of fibrinogen concentrate compared with cryoprecipitate for reversal of the antiplatelet effect of clopidogrel in an in vitro model, as assessed by multiple electrode platelet aggregometry, thromboelastometry, and modified thromboelastography.
Topics: Cardiac Catheterization; Clopidogrel; Factor VIII; Fibrinogen; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Thrombelastography; Ticlopidine; Treatment Outcome | 2015 |
Undiagnosed patent foramen ovale as a rare cause for branch retinal artery occlusion.
Topics: Adult; Clopidogrel; Echocardiography, Transesophageal; Fluorescein Angiography; Foramen Ovale, Patent; Fundus Oculi; Humans; Male; Platelet Aggregation Inhibitors; Retinal Artery Occlusion; Ticlopidine; Tomography, Optical Coherence; Vision Disorders; Visual Acuity | 2015 |
Impaired clopidogrel antiplatelet effects and age: Young patients at risk.
Topics: Age Factors; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Treatment Failure | 2015 |
Impact of prolonged dual antiplatelet therapy after acute myocardial infarction on 5-year mortality in the FAST-MI 2005 registry.
Topics: Aged; Aspirin; Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Ticlopidine; Time Factors | 2015 |
Accuracy of optical frequency domain imaging for evaluation of coronary adventitial vasa vasorum formation after stent implantation in pigs and humans - a validation study - .
Topics: Adventitia; Aged; Aged, 80 and over; Animals; Aspirin; Clopidogrel; Coronary Stenosis; Coronary Vessels; Disease Progression; Drug-Eluting Stents; Everolimus; Female; Humans; Interferometry; Male; Middle Aged; Neointima; Neovascularization, Physiologic; Platelet Aggregation Inhibitors; Postoperative Period; Prosthesis Implantation; Sirolimus; Stents; Swine; Swine, Miniature; Ticlopidine; Tomography, Optical Coherence; Vasa Vasorum; Vasculitis | 2015 |
Effects of Rivaroxaban on Platelet Activation and Platelet-Coagulation Pathway Interaction: In Vitro and In Vivo Studies.
Topics: Adenosine; Adult; Animals; Arteriovenous Shunt, Surgical; Aspirin; Blood Coagulation; Clopidogrel; Coronary Thrombosis; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Rivaroxaban; Thrombin; Ticagrelor; Ticlopidine | 2015 |
P2Y12 Receptor Localizes in the Renal Collecting Duct and Its Blockade Augments Arginine Vasopressin Action and Alleviates Nephrogenic Diabetes Insipidus.
Topics: Animals; Aquaporin 2; Arginine Vasopressin; Clopidogrel; Deamino Arginine Vasopressin; Diabetes Insipidus, Nephrogenic; Kidney Concentrating Ability; Kidney Medulla; Kidney Tubules, Collecting; Lithium; Male; Purinergic P2Y Receptor Antagonists; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptors, Purinergic P2Y12; RNA, Messenger; Ticlopidine; Water | 2015 |
Platelet transfusion reverses bleeding evoked by triple anti-platelet therapy including vorapaxar, a novel platelet thrombin receptor antagonist.
Topics: Animals; Aspirin; Bleeding Time; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Lactones; Macaca fascicularis; Platelet Aggregation Inhibitors; Platelet Transfusion; Pyridines; Receptors, Thrombin; Ticlopidine | 2015 |
Correlation Between SNPs in Candidate Genes and VerifyNow-Detected Platelet Responsiveness to Aspirin and Clopidogrel Treatment.
Topics: Aged; Asian People; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2015 |
Antithrombotic therapy in patients undergoing TAVI with concurrent atrial fibrillation. One center experience.
Topics: Acenocoumarol; Aged; Aged, 80 and over; Aortic Valve Stenosis; Atrial Fibrillation; Clopidogrel; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Male; Ticlopidine; Transcatheter Aortic Valve Replacement | 2015 |
Association of dual-antiplatelet therapy with reduced major adverse cardiovascular events in patients with symptomatic peripheral arterial disease.
Topics: Adult; Aged; Aged, 80 and over; Amputation, Surgical; Aspirin; California; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Critical Illness; Drug Therapy, Combination; Female; Humans; Intermittent Claudication; Ischemia; Kaplan-Meier Estimate; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Predictive Value of Tests; Propensity Score; Proportional Hazards Models; Registries; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Influence of Different β-Blockers on Platelet Aggregation in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy.
Topics: Adrenergic alpha-1 Receptor Antagonists; Aged; Aspirin; Bisoprolol; Carbazoles; Carvedilol; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Metoprolol; Middle Aged; Nebivolol; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Propanolamines; Prospective Studies; Ticlopidine; Treatment Outcome | 2016 |
Predictive value of high residual platelet reactivity by flow cytometry for outcomes of ischemic stroke patients on clopidogrel therapy.
Topics: Aged; Aged, 80 and over; Blood Platelets; Brain Ischemia; Clopidogrel; Female; Flow Cytometry; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Ticlopidine | 2015 |
Inflammatory and antioxidant pattern unbalance in "clopidogrel-resistant" patients during acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Antioxidants; Chemokine CCL4; Clopidogrel; Female; Humans; Interleukin-6; Male; Middle Aged; Oxidation-Reduction; Platelet Aggregation Inhibitors; Proteomics; Reactive Oxygen Species; Ticlopidine | 2015 |
Two young women with severe coronary arterial ostial narrowing: A potential subtype of Takayasu arteritis.
Topics: Adult; Aspirin; Clopidogrel; Coronary Angiography; Coronary Stenosis; Cyclophosphamide; Diagnosis, Differential; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Methylprednisolone; Monitoring, Physiologic; Platelet Aggregation Inhibitors; Rare Diseases; Sampling Studies; Takayasu Arteritis; Ticlopidine; Treatment Outcome; Young Adult | 2015 |
Impact of esomeprazole on platelet reactivity and clinical outcome according to CYP2C19 genotype in coronary heart disease patients during dual antiplatelet therapy.
Topics: Aged; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Esomeprazole; Ethnicity; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2015 |
Is a high maintenance dose of clopidogrel suitable for overcoming clopidogrel resistance in patients?
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2015 |
[Synergistic action of Compound Danshen Dripping Pill (CDDP) on Clopidogrel Bisulfate (CPG) counteracting platelet aggregation].
Topics: Animals; Bleeding Time; Blood Coagulation; Blood Coagulation Tests; Clopidogrel; Drugs, Chinese Herbal; Hemostatics; Partial Thromboplastin Time; Platelet Aggregation; Platelet Aggregation Inhibitors; Prothrombin Time; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Thrombin Time; Thrombosis; Ticlopidine | 2014 |
CYP2C19 LOF alleles confer no risk for HTPR but higher risk for recurrent ischemic events in clopidogrel treated elderly ACS patients.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Aged, 80 and over; Alleles; Blood Platelets; Clopidogrel; Cohort Studies; Confidence Intervals; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Geriatric Assessment; Humans; Male; Myocardial Ischemia; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Risk Assessment; Sex Factors; Ticlopidine; Treatment Outcome | 2015 |
In-hospital switching from clopidogrel to prasugrel following thrombolysis for ST-elevation myocardial infarction: a 3-year single center experience.
Topics: Aged; Clopidogrel; Female; Hospitalization; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; ST Elevation Myocardial Infarction; Tertiary Healthcare; Thrombosis; Ticlopidine | 2016 |
Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats.
Topics: Animals; Anticoagulants; Chromatography, Liquid; Clopidogrel; Drug Administration Schedule; Herb-Drug Interactions; Injections, Intraperitoneal; Isoflavones; Male; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Tandem Mass Spectrometry; Ticlopidine; Vasodilator Agents; Warfarin | 2015 |
Effectiveness of prolonged clopidogrel-based dual antiplatelet therapy after drug-eluting stent implantation: Evidence-based meta-analysis.
Topics: Aged; Aspirin; Clopidogrel; Coronary Restenosis; Drug Administration Schedule; Drug Combinations; Drug-Eluting Stents; Evidence-Based Medicine; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prevalence; Risk Factors; Survival Rate; Ticlopidine; Treatment Outcome | 2015 |
Selection of P2Y12 antagonist, treatment initiation, and predictors of high on-treatment platelet reactivity in a "Real World" registry.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Blood Platelets; Clinical Trials as Topic; Clopidogrel; Coronary Angiography; Drug Design; Female; Humans; Male; Middle Aged; Patient Admission; Percutaneous Coronary Intervention; Platelet Count; Prasugrel Hydrochloride; Precision Medicine; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Ticagrelor; Ticlopidine | 2015 |
Effects of anticoagulants on outcome of femoral neck fracture surgery.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Female; Femoral Neck Fractures; Humans; Male; Middle Aged; Postoperative Complications; Retrospective Studies; Ticlopidine; Warfarin | 2015 |
Clopidogrel is not associated with increased bleeding complications after full-mouth extraction: A retrospective study.
Topics: Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Ticlopidine; Time Factors; Tooth Extraction | 2015 |
Traditional clinical risk factors predict clopidogrel hypo-responsiveness in unselected patients undergoing non-emergent percutaneous coronary intervention.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine | 2016 |
Delayed clopidogrel transit during myocardial infarction evident on angiography.
Topics: Administration, Oral; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Humans; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Time Factors | 2015 |
Glanzmann's thrombasthenia: meeting the anticoagulation challenge.
Topics: Aminocaproic Acid; Aspirin; Clopidogrel; Factor VIIa; Hemorrhage; Humans; Isoantibodies; Male; Middle Aged; Platelet Transfusion; Recombinant Proteins; Thrombasthenia; Ticlopidine | 2015 |
Dual antiplatelet therapy tailored on platelet function test after coronary stent implantation: a real-world experience.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Stents; Ticlopidine | 2015 |
Analysis of the Interaction between Clopidogrel, Aspirin, and Proton Pump Inhibitors Using the FDA Adverse Event Reporting System Database.
Topics: Adverse Drug Reaction Reporting Systems; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Embolism; Female; Gastrointestinal Hemorrhage; Humans; Male; Odds Ratio; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Thrombosis; Ticlopidine; United States; United States Food and Drug Administration | 2015 |
Lichenoid dermatitis caused by thienopyridine derivatives.
Topics: Clopidogrel; Drug Eruptions; Humans; Lichenoid Eruptions; Male; Middle Aged; Thienopyridines; Ticlopidine | 2016 |
Antithrombotic therapy after transcatheter aortic valve implantation.
Topics: Aortic Valve Stenosis; Aspirin; Cardiac Catheterization; Clopidogrel; Female; Heart Valve Prosthesis Implantation; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Antiplatelets Versus Anticoagulation for Cervical Arterial Dissection.
Topics: Anticoagulants; Aortic Dissection; Aspirin; Carotid Artery, Internal, Dissection; Cervical Vertebrae; Clopidogrel; Dipyridamole; Drug Administration Schedule; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine; Treatment Outcome; Vertebral Artery Dissection | 2015 |
Ticagrelor-induced acute generalized exanthematous pustulosis.
Topics: Acute Coronary Syndrome; Acute Generalized Exanthematous Pustulosis; Adenosine; Aged; Biopsy; Clopidogrel; Drug Eruptions; Female; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2015 |
Activated Hemostatic Biomarkers in Patients with Implanted Left Ventricle Assist Devices: Are Heparin and/or Clopidogrel Justified?
Topics: Adult; Anticoagulants; Aspirin; Biomarkers; Clopidogrel; Drug Therapy, Combination; Fibrin Fibrinogen Degradation Products; Fibrinogen; Heart Failure; Heart Ventricles; Heart-Assist Devices; Heparin; Humans; Male; Platelet Activation; Platelet Aggregation; Ticlopidine; Warfarin | 2015 |
End-stage hypertrophic cardiomyopathy in a cat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Atenolol; Benzazepines; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cat Diseases; Cats; Clopidogrel; Diuretics; Furosemide; Male; Platelet Aggregation Inhibitors; Pyridazines; Ticlopidine | 2015 |
Bioactivation of clopidogrel and prasugrel: factors determining the stereochemistry of the thiol metabolite double bond.
Topics: Antithrombins; Clopidogrel; Glutathione; Humans; Microsomes, Liver; Molecular Structure; Prasugrel Hydrochloride; Prodrugs; Stereoisomerism; Sulfhydryl Compounds; Ticlopidine | 2015 |
The impact of therapeutic hypothermia on on-treatment platelet reactivity and clinical outcome in cardiogenic shock patients undergoing primary PCI for acute myocardial infarction: Results from the ISAR-SHOCK registry.
Topics: Acute Disease; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Female; Humans; Hypothermia, Induced; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; Shock, Cardiogenic; Ticlopidine; Treatment Outcome | 2015 |
A population-based study of the drug interaction between clopidogrel and angiotensin converting enzyme inhibitors.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Case-Control Studies; Clopidogrel; Databases, Factual; Drug Interactions; Drug Therapy, Combination; Female; Heart Failure; Humans; Lisinopril; Male; Myocardial Infarction; Perindopril; Platelet Aggregation Inhibitors; Ramipril; Recurrence; Ticlopidine; Treatment Outcome | 2015 |
Cardioembolic acute myocardial infarction associated with apical ballooning: Considerations.
Topics: Aged, 80 and over; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Therapy, Combination; Echocardiography; Electrocardiography; Enoxaparin; Female; Humans; Myocardial Infarction; Takotsubo Cardiomyopathy; Ticlopidine | 2015 |
Very late bioresorbable vascular scaffold thrombosis: a new clinical entity.
Topics: Absorbable Implants; Aged, 80 and over; Anterior Wall Myocardial Infarction; Brachytherapy; Clopidogrel; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Metals; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Severity of Illness Index; Stents; Ticlopidine; Time Factors; Tomography, Optical Coherence; Treatment Outcome | 2015 |
The association of ABCC3 promoter methylation with clopidogrel response in Chinese ischemic stroke patients.
Topics: Aged; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; DNA Methylation; Female; Heterozygote; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Mutation; Platelet Aggregation Inhibitors; Promoter Regions, Genetic; RNA, Messenger; Stroke; Ticlopidine | 2014 |
Association of the use of amlodipine with clopidogrel response in Chinese patients undergoing percutaneous coronary intervention.
Topics: Adolescent; Adult; Aged; Amlodipine; Antihypertensive Agents; Aromatase; Asian People; Clopidogrel; Cohort Studies; Drug Interactions; Drug Resistance; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome; Young Adult | 2014 |
Clopidogrel versus aspirin in patients with recent ischemic stroke and established peripheral artery disease: an economic evaluation in a Chinese setting.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cost-Benefit Analysis; Humans; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Secondary Prevention; Stroke; Ticlopidine | 2015 |
Comparative fasting bioavailability of two clopidogrel formulations in healthy Mediterranean volunteers: an in vitro-in vivo correlation.
Topics: Adult; Arabs; Biological Availability; Chemistry, Pharmaceutical; Clopidogrel; Female; Half-Life; Healthy Volunteers; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Reference Standards; Smoking; Solubility; Ticlopidine; Young Adult | 2015 |
Unfractionated heparin-clopidogrel combination in ST-elevation myocardial infarction not receiving reperfusion therapy.
Topics: Aged; Anticoagulants; Clopidogrel; Drug Therapy, Combination; Enoxaparin; Europe; Female; Fibrinolytic Agents; Health Care Surveys; Heparin; Hospital Mortality; Humans; Intracranial Hemorrhages; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Propensity Score; Registries; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Uninterrupted perioperative clopidogrel and bleeding-related events after total joint arthroplasty: a case series.
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine | 2015 |
Monitoring Residual Platelet Activity Among Patients With Acute Coronary Syndrome Post-PCI by Modified Impedance Whole Blood Platelet Aggregation and Release Method.
Topics: Acute Coronary Syndrome; Adult; Blood Platelets; Clopidogrel; Drug Monitoring; Electric Impedance; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Function Tests; Postoperative Period; Ticlopidine | 2016 |
The impact of cytochrome P450 2C19 polymorphism on the occurrence of one-year in-stent restenosis in patients who underwent percutaneous coronary intervention: A case-match study.
Topics: Angioplasty, Balloon, Coronary; Case-Control Studies; Clopidogrel; Coronary Restenosis; Cytochrome P-450 CYP2C19; Female; Humans; Iran; Logistic Models; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prevalence; Registries; Stents; Ticlopidine | 2015 |
Prehospital administration of P2Y12 inhibitors and early coronary reperfusion in primary PCI: an observational comparative study.
Topics: Adenosine; Aged; Clopidogrel; Coronary Angiography; Coronary Circulation; Drug Administration Schedule; Emergency Medical Services; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
ABCB1 hypomethylation is associated with decreased antiplatelet effects of clopidogrel in Chinese ischemic stroke patients.
Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Asian People; ATP Binding Cassette Transporter, Subfamily B; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; DNA Methylation; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Promoter Regions, Genetic; Stroke; Ticlopidine; Young Adult | 2015 |
Management and outcome of major bleeding in patients on triple therapy after coronary stenting. Clues from the WARfarin and coronary STENTing (WAR-STENT) registry.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Registries; Stents; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2015 |
Pre-procedural dual antiplatelet therapy and bleeding events following transcatheter aortic valve implantation (TAVI).
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Transcatheter Aortic Valve Replacement | 2015 |
Effect of Clopidogrel on Platelet CD Markers in Normal Individuals and in Patients with Untreated Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Biomarkers; Blood Platelets; Case-Control Studies; Clopidogrel; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Pre-treatment with dual antiplatelet therapy in patients with non-ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Australia; Clopidogrel; Female; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Registries; Ticlopidine; Treatment Outcome | 2015 |
Calcium-Channel Blockers Attenuate the Antiplatelet Effect of Clopidogrel.
Topics: Adenosine Diphosphate; Aged; Angioplasty; Aspirin; Calcium Channel Blockers; Clopidogrel; Dihydropyridines; Drug Interactions; Female; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stents; Ticlopidine | 2015 |
Clopidogrel use and cancer-specific mortality: a population-based cohort study of colorectal, breast and prostate cancer patients.
Topics: Aged; Aged, 80 and over; Breast Neoplasms; Cause of Death; Clopidogrel; Colorectal Neoplasms; Databases, Factual; Drug Prescriptions; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Patient Safety; Pharmacoepidemiology; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prostatic Neoplasms; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; United Kingdom | 2015 |
[Positive effect of low-activity thromboxane A synthase gene on prognosis in coronary heart disease].
Topics: Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Data Interpretation, Statistical; Drug Resistance; Female; Gene Frequency; Humans; Kaplan-Meier Estimate; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prognosis; Prospective Studies; Risk; Thromboxane-A Synthase; Ticlopidine | 2015 |
Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction.
Topics: Adenosine; Administration, Oral; Animals; Apoptosis; Cardiotonic Agents; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Injections, Intraperitoneal; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Signal Transduction; Ticagrelor; Ticlopidine; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2015 |
Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population.
Topics: Adult; Clopidogrel; Humans; Middle Aged; Myocardial Infarction; Prospective Studies; Proton Pump Inhibitors; Risk Factors; Ticlopidine; Young Adult | 2015 |
Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Biomarkers; Chemokine CCL2; Clopidogrel; Disease Models, Animal; Disease Progression; E-Selectin; Gene Expression Regulation; Genetic Predisposition to Disease; Lipids; Lymphokines; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Phenotype; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Derived Growth Factor; RNA, Messenger; Ticlopidine; Time Factors; Vascular Remodeling | 2016 |
Body Mass Index and Platelet Reactivity During Dual Antiplatelet Therapy With Clopidogrel or Ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Blood Platelets; Body Mass Index; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2015 |
Mean platelet volume and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Humans; Male; Mean Platelet Volume; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine | 2015 |
Effect of fluvoxamine on the pharmacokinetics and pharmacodynamics of clopidogrel in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Area Under Curve; Biotransformation; Carboxylic Acids; Clopidogrel; Drug Interactions; Fluvoxamine; Half-Life; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Ticlopidine | 2015 |
Assessing the Quality of Care for Patients With Acute Myocardial Infarction in China.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; China; Clopidogrel; Coronary Angiography; Female; Hospital Mortality; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Quality Indicators, Health Care; Ticlopidine | 2015 |
[Effect of Clopidogrel on Pharmacokinetic of Fufang Danshen Dripping Pill (FDDP)].
Topics: Animals; Chromatography, High Pressure Liquid; Clopidogrel; Drug Synergism; Drugs, Chinese Herbal; Ginsenosides; Rats; Rats, Sprague-Dawley; Ticlopidine | 2014 |
How to test the effect of aspirin and clopidogrel in patients on dual antiplatelet therapy?
Topics: Aspirin; Case-Control Studies; Clopidogrel; Drug Interactions; Drug Monitoring; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Interaction of Panax quinquefolius Saponin and Dual Antiplatelets on Vascular Endothelial Function in Rats with Acute Myocardial Infarction.
Topics: Animals; Aspirin; Clopidogrel; Coronary Vessels; Endothelial Cells; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Rats; Saponins; Ticlopidine; Ventricular Remodeling | 2015 |
Determinants of subacute response to clopidogrel: relative impact of CYP2C19 genotype and PGE1/adenylate cyclase signalling.
Topics: Adenylyl Cyclases; Adult; Aged; Aged, 80 and over; Alprostadil; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Signal Transduction; Ticlopidine | 2015 |
The impact of genetic polymorphisms of drug metabolizing enzymes on the pharmacodynamics of clopidogrel under steady state conditions.
Topics: Adolescent; Adult; Aryldialkylphosphatase; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Genotype; Humans; Inactivation, Metabolic; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Young Adult | 2015 |
Prediction of high risk of non-adherence to antiplatelet treatment.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Medication Adherence; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Poland; Prospective Studies; Ticlopidine | 2016 |
Financial Analysis of CYP2C19 Genotyping in Patients Receiving Dual Antiplatelet Therapy Following Acute Coronary Syndrome and Percutaneous Coronary Intervention.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Genetic Testing; Genotype; Humans; Managed Care Programs; Models, Economic; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thrombosis; Ticagrelor; Ticlopidine | 2015 |
Relationship between low response to clopidogrel and periprocedural ischemic events with coil embolization for intracranial aneurysms.
Topics: Adult; Aged; Brain Ischemia; Clopidogrel; Diffusion Magnetic Resonance Imaging; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Perioperative Care; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Treatment Outcome | 2016 |
Association of rivaroxaban anticoagulation and spontaneous vitreous hemorrhage.
Topics: Aged; Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Clopidogrel; Factor Xa Inhibitors; Humans; Male; Platelet Aggregation Inhibitors; Rivaroxaban; Ticlopidine; Visual Acuity; Vitreous Hemorrhage; Warfarin | 2015 |
Clinical outcomes of multiple chronic total occlusions in coronary arteries according to three therapeutic strategies: Bypass surgery, percutaneous intervention and medication.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Occlusion; Coronary Vessels; Death; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2015 |
[CLINICAL AND PHARMACOLOGICAL FACTORS INFLUENCING RESISTANCE TO CLOPIDOGREL IN PATIENTS WITH CARDIOVASCULAR DISEASES].
Topics: Alleles; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Drug Resistance; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Retrospective Studies; Thromboxane-A Synthase; Ticlopidine | 2015 |
International central adjudication committee in the PLATO trial: independent body of experts or friendly family picnic?
Topics: Acute Coronary Syndrome; Adenosine; Biomedical Research; Clopidogrel; Conflict of Interest; Humans; Peer Review; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Selection Bias; Ticagrelor; Ticlopidine | 2015 |
[Ultrasound-guided central venous access in patients with uncorrected coagulopathy].
Topics: Adult; Aged; Anticoagulants; Blood Coagulation Disorders; Catheterization, Central Venous; Clopidogrel; Critical Care; Critical Illness; Female; Humans; Hungary; International Normalized Ratio; Jugular Veins; Male; Medical Records; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Retrospective Studies; Ticlopidine; Ultrasonography, Doppler, Color; Ultrasonography, Interventional; Unnecessary Procedures | 2015 |
Redesigning TRACER trial after TRITON.
Topics: Acute Coronary Syndrome; Aspirin; Clinical Trials as Topic; Clopidogrel; Drug Evaluation; Drug Therapy, Combination; Hemorrhage; Humans; Lactones; Neoplasms; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Pyridines; Research Design; Ticlopidine | 2015 |
Comparison of Angiographic Outcomes of Side Branch Ostium at Bifurcation Coronary Lesion between Two-stent and One-stent Techniques.
Topics: Aspirin; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Vessels; Drug-Eluting Stents; Female; Heart; Heart Septal Defects, Atrial; Humans; Male; Middle Aged; Myocardial Revascularization; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2015 |
Clopidogrel Napadisilate Monohydrate Loaded Surface-Modified Solid Dispersion: Physicochemical Characterization and in Vivo Evaluation.
Topics: Animals; Biological Availability; Calorimetry, Differential Scanning; Clopidogrel; Drug Delivery Systems; Hypromellose Derivatives; Male; Microscopy, Electron, Scanning; Platelet Aggregation Inhibitors; Polysorbates; Powder Diffraction; Rats, Sprague-Dawley; Solubility; Ticlopidine; X-Ray Diffraction | 2015 |
An Extraordinary Case Associated with an Allergic Reaction to Clopidogrel: Coronary Artery Spasm or Kounis Syndrome?
Topics: Acute Coronary Syndrome; Clopidogrel; Coronary Vasospasm; Drug Hypersensitivity; Humans; Male; Middle Aged; Syndrome; Ticlopidine | 2015 |
Cytochrome P450 CYP 2C19*2 Associated with Adverse 1-Year Cardiovascular Events in Patients with Acute Coronary Syndrome.
Topics: Activation, Metabolic; Acute Coronary Syndrome; Aged; Alleles; Angina Pectoris; Aspirin; Clopidogrel; Coronary Restenosis; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prodrugs; Prognosis; Prospective Studies; Recurrence; Stents; Ticlopidine; Treatment Outcome | 2015 |
Evaluation of S100B in the diagnosis of suspected intracranial hemorrhage after minor head injury in patients who are receiving platelet aggregation inhibitors and in patients 65 years of age and older.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Biomarkers; Clopidogrel; Craniocerebral Trauma; Female; Glasgow Coma Scale; Humans; Intracranial Hemorrhage, Traumatic; Male; Middle Aged; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; S100 Calcium Binding Protein beta Subunit; Ticlopidine | 2015 |
Individualised dual antiplatelet therapy in a patient with short bowel syndrome after acute myocardial infarction with coronary artery stenting.
Topics: Abdominal Pain; Anterior Wall Myocardial Infarction; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Fatal Outcome; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Precision Medicine; Short Bowel Syndrome; Stents; Ticlopidine | 2015 |
Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development.
Topics: Biological Phenomena; Clopidogrel; Humans; Microsomes, Liver; Piperidines; Platelet Aggregation Inhibitors; Prodrugs; Stereoisomerism; Ticlopidine | 2015 |
Duration of clopidogrel-based dual antiplatelet therapy and clinical outcomes after endeavor sprint zotarolimus-eluting stent implantation in patients presenting with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Cause of Death; Clopidogrel; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Republic of Korea; Sirolimus; Ticlopidine; Treatment Outcome | 2015 |
The change in platelet count in patients with acute coronary syndrome 6 months after coronary stent implantation.
Topics: Acute Coronary Syndrome; Adult; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Stents; Ticlopidine; Time Factors | 2015 |
Perioperative Management of Antiplatelets and Anticoagulants Among Patients Undergoing Elective Transurethral Resection of the Prostate--A Single Institution Experience.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Aspirin, Dipyridamole Drug Combination; Clopidogrel; Elective Surgical Procedures; Enoxaparin; Hemorrhage; Humans; Male; Middle Aged; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Prostate; Prostatic Hyperplasia; Retrospective Studies; Thromboembolism; Ticlopidine; Transurethral Resection of Prostate; Victoria; Warfarin; Withholding Treatment | 2015 |
[The ISAR-SAFE study].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Disease; Coronary Restenosis; Drug Administration Schedule; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Postoperative Complications; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Research Design; Risk; Thrombosis; Ticlopidine | 2015 |
National Quality Assessment of Early Clopidogrel Therapy in Chinese Patients With Acute Myocardial Infarction (AMI) in 2006 and 2011: Insights From the China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE)-Retrospective AMI Study.
Topics: Aged; Asian People; China; Clopidogrel; Drug Administration Schedule; Female; Healthcare Disparities; Humans; Male; Middle Aged; Myocardial Infarction; National Health Programs; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Quality Improvement; Quality Indicators, Health Care; Residence Characteristics; Retrospective Studies; Risk Factors; Rural Health Services; Ticlopidine; Time Factors; Treatment Outcome; Urban Health Services | 2015 |
Iatrogenic Endobronchial Bleeding: Speed Things Up or Cool It Down?
Topics: Biopsy; Bronchoscopy; Clopidogrel; Epinephrine; Hemorrhage; Humans; Iatrogenic Disease; Platelet Aggregation Inhibitors; Prognosis; Risk Factors; Sodium Chloride; Ticlopidine; Tranexamic Acid; Vasoconstrictor Agents | 2015 |
Development of a sensitive and fast UHPLC-MS/MS method for determination of clopidogrel, clopidogrel acid and clopidogrel active metabolite H4 in human plasma.
Topics: Blood Chemical Analysis; Calibration; Chromatography, High Pressure Liquid; Clopidogrel; Humans; Microsomes, Liver; Purinergic P2Y Receptor Antagonists; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry; Temperature; Ticlopidine | 2015 |
[SECONDARY PREVENTION IN PATIENTS WITH ACUTE CORONARY SYNDROME HOSPITALIZED IN INTERNAL MEDICINE DEPARTMENTS].
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Atrial Fibrillation; Cardiology Service, Hospital; Clopidogrel; Female; Hospital Departments; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Israel; Male; Medication Therapy Management; Middle Aged; Patient Discharge; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Retrospective Studies; Secondary Prevention; Ticlopidine | 2015 |
Prasugrel Versus Clopidogrel: A Comparative Examination of Local Bleeding After Dental Extraction in Patients Receiving Dual Antiplatelet Therapy.
Topics: Aged; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2015 |
Management of a Patient with a Thoracic Epidural After Accidental Clopidogrel Administration.
Topics: Adenosine Diphosphate; Aged; Analgesia, Epidural; Catheters, Indwelling; Clopidogrel; Device Removal; Humans; Male; Medication Errors; Platelet Aggregation Inhibitors; Thoracotomy; Ticlopidine | 2015 |
Bifrontal headache · blurred vision · vomiting · Dx?
Topics: Aspirin; Clopidogrel; Diagnosis, Differential; Drug Therapy, Combination; Female; Headache; Humans; Magnetic Resonance Imaging; Middle Aged; Platelet Aggregation Inhibitors; Posterior Leukoencephalopathy Syndrome; Ticlopidine; Tomography, X-Ray Computed; Vision Disorders; Vomiting | 2015 |
Influence of Genetic Polymorphisms on Clopidogrel Response and Clinical Outcomes in Patients with Acute Ischemic Stroke CYP2C19 Genotype on Clopidogrel Response.
Topics: Aged; Biomarkers, Pharmacological; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Genotype; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Prospective Studies; Random Allocation; Stroke; Ticlopidine; Treatment Outcome | 2015 |
The effect of acenocoumarol on the antiplatelet effect of clopidogrel.
Topics: Acenocoumarol; Aged; Aged, 80 and over; Anticoagulants; Blood Platelets; Chi-Square Distribution; Clopidogrel; Drug Interactions; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Netherlands; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polypharmacy; Propensity Score; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Risk Factors; Ticlopidine | 2015 |
Ventriculostomy-Related Hemorrhage After Treatment of Acutely Ruptured Aneurysms: The Influence of Anticoagulation and Antiplatelet Treatment.
Topics: Acute Disease; Adult; Aged; Aneurysm, Ruptured; Anticoagulants; Aspirin; Cerebral Hemorrhage; Clopidogrel; Endovascular Procedures; Female; Heparin, Low-Molecular-Weight; Humans; Hydrocephalus; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Thromboembolism; Ticlopidine; Tirofiban; Tyrosine; Ventriculostomy | 2015 |
Clopidogrel response variability is associated with endothelial dysfunction in coronary artery disease patients receiving dual antiplatelet therapy.
Topics: Activation, Metabolic; Aged; Aspirin; Brachial Artery; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Diabetes Mellitus; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Female; Genotype; Humans; Hyperlipidemias; Male; Middle Aged; Obesity; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Smoking; Stents; Thrombophilia; Ticlopidine; Vasodilation | 2015 |
Long-term Outcomes of Medical Therapy Versus Coronary Revascularisation in Patients with Intermediate Stenoses Guided by Pressure Wire.
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Stenosis; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2015 |
Early surgery is feasible in patients with hip fractures who are on clopidogrel therapy.
Topics: Aged; Aged, 80 and over; Blood Transfusion; Clopidogrel; Female; Femoral Neck Fractures; Hip Fractures; Humans; Length of Stay; Male; Platelet Aggregation Inhibitors; Postoperative Period; Retrospective Studies; Risk Factors; Ticlopidine; Time-to-Treatment | 2015 |
Acute spinal cord compression: a rare complication of dual antiplatelet therapy.
Topics: Acute Disease; Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Fatal Outcome; Female; Hematoma; Humans; Platelet Aggregation Inhibitors; Pressure Ulcer; Sepsis; Spinal Cord Compression; Ticlopidine | 2015 |
Antithrombotic drugs and subarachnoid haemorrhage risk. A nationwide case-control study in Denmark.
Topics: Aged; Aspirin; Case-Control Studies; Clopidogrel; Denmark; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Neurosurgical Procedures; Postoperative Complications; Risk; Subarachnoid Hemorrhage; Thrombosis; Ticlopidine; Vitamin K | 2015 |
Safety of Prasugrel Loading Doses in Patients Pre-Loaded With Clopidogrel in the Setting of Primary Percutaneous Coronary Intervention: Results of a Nonrandomized Observational Study.
Topics: Aged; Clopidogrel; Drug Administration Schedule; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Risk Assessment; Risk Factors; Switzerland; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Outcomes with prolonged clopidogrel therapy after coronary stenting in patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug-Eluting Stents; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Metals; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Prosthesis Design; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome; United States; United States Department of Veterans Affairs | 2015 |
Purpuric herpes zoster in patients in therapy with clopidogrel.
Topics: Acyclovir; Aged; Antiviral Agents; Clopidogrel; Female; Herpes Zoster; Humans; Male; Pruritus; Ticlopidine; Treatment Outcome; Valacyclovir; Valine | 2015 |
Implementation of Cell Samples as Controls in National Proficiency Testing for Clopidogrel Therapy-Related CYP2C19 Genotyping in China: A Novel Approach.
Topics: Acute Coronary Syndrome; Alleles; Cells, Cultured; China; Clopidogrel; Cytochrome P-450 CYP2C19; Genetic Testing; Genotype; Health Plan Implementation; Humans; Laboratory Proficiency Testing; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Genetic; Ticlopidine | 2015 |
Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel.
Topics: Animals; Clopidogrel; Cytochrome P-450 Enzyme System; Female; Humans; Male; Methylation; Methyltransferases; Microsomes, Liver; Platelet Aggregation Inhibitors; Rats; Stereoisomerism; Ticlopidine | 2015 |
Clopidogrel Enhances Mesenchymal Stem Cell Proliferation Following Periodontitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Movement; Cell Proliferation; Clopidogrel; Gingiva; Male; Mesenchymal Stem Cells; Osteoblasts; Periodontitis; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Ticlopidine | 2015 |
Simultaneous quantitation of acetylsalicylic acid and clopidogrel along with their metabolites in human plasma using liquid chromatography tandem mass spectrometry.
Topics: Aspirin; Chromatography, Liquid; Clopidogrel; Drug Monitoring; Drug Stability; Humans; Limit of Detection; Reproducibility of Results; Tandem Mass Spectrometry; Ticlopidine | 2016 |
Soluble CD40 Ligand in Aspirin-Treated Patients Undergoing Cardiac Catheterization.
Topics: Aspirin; Cardiac Catheterization; Cardiovascular Diseases; CD40 Ligand; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Platelet reactivity in MitraClip patients.
Topics: Aspirin; Clopidogrel; Cohort Studies; Heart Valve Prosthesis Implantation; Hemorrhage; Ischemia; Mitral Valve Insufficiency; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2016 |
A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets.
Topics: Animals; Blood Platelets; Cells, Cultured; Clopidogrel; Clot Retraction; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Receptors, Purinergic P2Y12; Tetraspanin 24; Tetraspanins; Thrombosis; Ticlopidine | 2015 |
Predictors of high on-clopidogrel platelet reactivity in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Area Under Curve; Blood Platelets; C-Reactive Protein; Clopidogrel; Coronary Angiography; Logistic Models; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prospective Studies; Risk Factors; Smoking; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Obesity and antiplatelet effects of acetylsalicylic acid and clopidogrel in patients with stable angina pectoris after percutaneous coronary intervention.
Topics: Aged; Angina, Stable; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Obesity; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2015 |
Association of CYP2C19, CYP3A5 and GPIIb/IIIa gene polymorphisms with Aspirin and Clopidogrel Resistance in a cohort of Indian patients with Coronary Artery Disease.
Topics: Aged; Alleles; Antigens, Human Platelet; Aspirin; Case-Control Studies; Clopidogrel; Cohort Studies; Comorbidity; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Resistance; Female; Genotype; Humans; India; Integrin beta3; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk Factors; Ticlopidine; Treatment Outcome | 2015 |
CYP2C19*2 and Other Allelic Variants Affecting Platelet Response to Clopidogrel Tested by Thrombelastography in Patients with Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Aged; Alleles; Asian People; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Thrombelastography; Ticlopidine | 2015 |
Antiplatelet therapy in Takotsubo cardiomyopathy: does it improve cardiovascular outcomes during index event?
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Heart Failure; Hospital Mortality; Humans; Length of Stay; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Severity of Illness Index; Stroke; Takotsubo Cardiomyopathy; Ticlopidine; Treatment Outcome | 2016 |
Cangrelor inhibits the binding of the active metabolites of clopidogrel and prasugrel to P2Y12 receptors in vitro.
Topics: Adenosine Monophosphate; Binding, Competitive; Clopidogrel; Humans; In Vitro Techniques; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine | 2016 |
Clopidogrel and CYP2C19: pharmacogenetic testing ready for clinical prime time?
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Drug Monitoring; Genotyping Techniques; Humans; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prodrugs; Ticlopidine | 2015 |
Comparing prasugrel to twice daily clopidogrel post percutaneous coronary intervention in a Veterans Affairs population.
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Retrospective Studies; Stroke; Ticlopidine; United States; United States Department of Veterans Affairs | 2015 |
Clopidogrel Resistance in Neurovascular Stenting: Correlations between Light Transmission Aggregometry, VerifyNow, and the Multiplate.
Topics: Aged; Brain Ischemia; Clopidogrel; Drug Resistance; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Intracranial Embolism; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Statistics as Topic; Stents; Ticlopidine | 2015 |
Independent Predictors of Major Adverse Events following Coronary Stenting over 28 Months of Follow-Up.
Topics: Acute Coronary Syndrome; Adult; Aged; Aspirin; Case-Control Studies; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Echocardiography; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Plasminogen Activator Inhibitor 1; Postoperative Complications; Prospective Studies; Risk Factors; Thrombosis; Ticlopidine; Treatment Outcome; von Willebrand Factor | 2015 |
Dual Antiplatelet Therapy Prior to Expedited Carotid Surgery Reduces Recurrent Events Prior to Surgery without Significantly Increasing Peri-operative Bleeding Complications.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carotid Stenosis; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Endarterectomy, Carotid; England; Female; Humans; Ischemic Attack, Transient; Male; Medical Audit; Middle Aged; Odds Ratio; Patient Transfer; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prevalence; Prospective Studies; Recurrence; Risk Assessment; Risk Factors; Severity of Illness Index; Ticlopidine; Time Factors; Time-to-Treatment; Treatment Outcome | 2015 |
Platelet reactivity and hemorrhage risk in neurointerventional procedures under dual antiplatelet therapy.
Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Embolization, Therapeutic; Female; Hemorrhage; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk; ROC Curve; Stents; Ticlopidine; Treatment Outcome | 2016 |
Optimal timing of clopidogrel discontinuation in Japanese patients: platelet aggregation test using the VerifyNow® system.
Topics: Aged; Aortic Valve; Bleeding Time; Cardiac Surgical Procedures; Clopidogrel; Coronary Artery Bypass, Off-Pump; Elective Surgical Procedures; Female; Humans; Male; Mitral Valve; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Hemorrhage; Preoperative Care; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2015 |
Failure of the Platelet Function Assay (PFA)-100 to detect antiplatelet agents.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelet Disorders; Brain Injuries; Clopidogrel; False Negative Reactions; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Retrospective Studies; Stroke; Ticlopidine | 2015 |
Impact of residual platelet reactivity under clopidogrel treatment for lesions and the clinical outcome after drug-eluting stent implantation in patients with hemodialysis.
Topics: Aged; Angina, Stable; Aspirin; Blood Platelets; Case-Control Studies; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2016 |
Is Acute Carotid Artery Stent Thrombosis an Avoidable Complication?
Topics: Aged; Aged, 80 and over; Aspirin; Carotid Artery Thrombosis; Cerebral Angiography; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2015 |
Clopidogrel Resistance after Minor Ischemic Stroke or Transient Ischemic Attack is Associated with Radiological Cerebral Small-Vessel Disease.
Topics: Aged; Blood Glucose; Carotid Artery Diseases; Cerebral Small Vessel Diseases; Clopidogrel; Cohort Studies; Female; Glomerular Filtration Rate; Humans; Ischemic Attack, Transient; Male; Middle Aged; Neuroimaging; Platelet Aggregation; Platelet Aggregation Inhibitors; Radiography; Statistics, Nonparametric; Stroke; Sweden; Ticlopidine; Ultrasonography | 2015 |
Effects of Clopidogrel and Proton Pump Inhibitors on Cardiovascular Events in Patients with Type 2 Diabetes Mellitus after Drug-Eluting Stent Implantation: A Nationwide Cohort Study.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Artery Bypass; Diabetes Mellitus, Type 2; Drug-Eluting Stents; Female; Humans; Male; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2015 |
Clopidogrel inhibits angiogenesis of gastric ulcer healing via downregulation of vascular endothelial growth factor receptor 2.
Topics: Animals; Cell Proliferation; Clopidogrel; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Gastric Mucosa; Human Umbilical Vein Endothelial Cells; Humans; Male; Neovascularization, Physiologic; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Stomach Ulcer; Ticlopidine; Vascular Endothelial Growth Factor A | 2016 |
A Novel Use of Direct Platelet Application During Surgery for Clopidogrel-Associated Intracerebral Hemorrhage.
Topics: Aneurysm, False; Aneurysm, Ruptured; Cerebral Angiography; Cerebral Hemorrhage; Clopidogrel; Female; Hemostasis; Humans; Intraoperative Care; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Ticlopidine; Treatment Outcome; Vertebral Artery Dissection | 2015 |
Anti-platelet pre-treatment for atrial fibrillation patients on warfarin referred for coronary angiography/stenting because of non-ST-elevation acute coronary syndrome: An alternative proposal.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Atrial Fibrillation; Clopidogrel; Coronary Angiography; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Warfarin | 2015 |
Ticagrelor shift from PLATO to PEGASUS: Vanished mortality benefit, excess cancer deaths, massive discontinuations, and overshooting target events.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Follow-Up Studies; Hemorrhage; Humans; Mortality; Neoplasms; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Sepsis; Ticagrelor; Ticlopidine | 2015 |
Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.
Topics: Activation, Metabolic; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulation, Enzymologic; Gene Frequency; Genotype; Humans; Hydroxylation; Infant; Infant, Newborn; Kinetics; Linear Models; Liver; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Multivariate Analysis; Oxidation-Reduction; Pharmacogenomic Variants; Phenotype; Substrate Specificity; Ticlopidine; Young Adult | 2016 |
Coronary artery bypass grafting-related bleeding complications in patients treated with ticagrelor or clopidogrel: a nationwide study.
Topics: Adenosine; Aged; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Registries; Reoperation; Retrospective Studies; Sweden; Ticagrelor; Ticlopidine; Time Factors | 2016 |
Prognostic impact of high residual platelet reactivity after chronic total occlusion percutaneous coronary intervention in patients with diabetes mellitus.
Topics: Aged; Blood Platelets; Chronic Disease; Clopidogrel; Coronary Occlusion; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Incidence; Italy; Male; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Retrospective Studies; Survival Rate; Ticlopidine; Time Factors | 2015 |
Optical coherence tomography analysis of the stent strut and prediction of resolved strut malapposition at 3 months after 2nd-generation drug-eluting stent implantation.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Drug-Eluting Stents; Everolimus; Female; Humans; Japan; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Sirolimus; Thrombosis; Ticlopidine; Tomography, Optical Coherence | 2016 |
Long-Term Outcomes in Patients With Diabetes Mellitus Related to Prolonging Clopidogrel More Than 12 Months After Coronary Stenting.
Topics: Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Cause of Death; Clopidogrel; Cohort Studies; Coronary Artery Disease; Databases, Factual; Diabetes Mellitus; Drug Administration Schedule; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Insulin; Long-Term Care; Male; Medicare; Middle Aged; Multivariate Analysis; Platelet Aggregation Inhibitors; Postoperative Care; Propensity Score; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Severity of Illness Index; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome; United States; Veterans Disability Claims | 2015 |
The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing.
Topics: Cardiotonic Agents; Clopidogrel; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Perfusion Imaging; Prevalence; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity; Ticlopidine; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2016 |
Does clopidogrel affect the efficacy of myocardial perfusion imaging?
Topics: Clopidogrel; Humans; Myocardial Infarction; Myocardial Perfusion Imaging; Ticlopidine; Treatment Outcome | 2016 |
Association between CYP2C19 Polymorphisms and Outcomes in Cerebral Endovascular Therapy.
Topics: Adult; Aged; Alleles; Brain Ischemia; Cerebrovascular Disorders; Clopidogrel; Cytochrome P-450 CYP2C19; Embolization, Therapeutic; Endovascular Procedures; Female; Genetic Predisposition to Disease; Genotype; Humans; Longitudinal Studies; Male; Middle Aged; Polymorphism, Genetic; Prospective Studies; Stents; Ticlopidine | 2016 |
[Clopidogrel versus prasugrel in acute coronary syndrome treated with coronary angioplasty].
Topics: Acute Coronary Syndrome; Angioplasty; Clopidogrel; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2015 |
Accumetrics-based clopidogrel dosing in endovascular neurosurgery.
Topics: Aged; Aspirin; Cerebral Hemorrhage; Clopidogrel; Drug Therapy, Combination; Endovascular Procedures; Female; Humans; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Thromboembolism; Ticlopidine; Treatment Outcome | 2015 |
Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy.
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Postoperative Hemorrhage; Risk Factors; Surgical Flaps; Ticlopidine; Wound Healing | 2015 |
Age- and Gender-related Disparities in Primary Percutaneous Coronary Interventions for Acute ST-segment elevation Myocardial Infarction.
Topics: Age Factors; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Female; Geriatrics; Hospitals; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Sex Characteristics; Switzerland; Ticlopidine; Treatment Outcome | 2015 |
C3435T polymorphism of the ABCB1 gene is associated with poor clopidogrel responsiveness in a Mexican population undergoing percutaneous coronary intervention.
Topics: ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Female; Humans; Male; Mexico; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2015 |
Low platelet activity predicts 30 days mortality in patients undergoing heart surgery.
Topics: Adenosine Diphosphate; Aged; Aortic Valve; Arachidonic Acid; Area Under Curve; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Erythrocyte Transfusion; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Risk Factors; Survival Analysis; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
Does "smoker's paradox" exist in clopidogrel-treated Turkish patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Retrospective Studies; ROC Curve; Smoking; Ticlopidine; Treatment Outcome; Turkey | 2016 |
Interest of Antiplatelet Drug Testing after an Acute Ischemic Stroke.
Topics: Aged; Aspirin; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Stroke; Ticlopidine; United States | 2015 |
Underutilisation of Guideline-based Therapy Primary Prevention among Patients Presenting with AF-related Ischaemic Stroke.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Brain Ischemia; Clopidogrel; Dabigatran; Dipyridamole; Female; Guideline Adherence; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Primary Prevention; Pyrazoles; Pyridones; Rivaroxaban; Stroke; Ticlopidine; Warfarin | 2015 |
Impact of Switching From Prasugrel to Clopidogrel Shortly After a Percutaneous Coronary Intervention Without a Loading Dose of Clopidogrel.
Topics: Clopidogrel; Coronary Angiography; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Care; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Effects of prasugrel pretreatment on angiographic myocardial perfusion parameters in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.
Topics: Aged; Aspirin; Case-Control Studies; Clopidogrel; Coronary Angiography; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Perfusion Imaging; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Premedication; Ticlopidine; Treatment Outcome | 2015 |
Clopidogrel attenuates lithium-induced alterations in renal water and sodium channels/transporters in mice.
Topics: Aldosterone; Animals; Aquaporin 2; Aquaporins; Arginine Vasopressin; Body Water; Clopidogrel; Dinoprostone; Epithelial Sodium Channels; Kidney; Lithium; Male; Mice; Platelet Aggregation Inhibitors; Polyuria; Receptors, Purinergic P2Y12; Sodium Channels; Solute Carrier Family 12, Member 1; Ticlopidine | 2015 |
Early hypoattenuated leaflet thickening and restricted leaflet motion of a Lotus transcatheter heart valve detected by 4D computed tomography angiography.
Topics: Aged, 80 and over; Anticoagulants; Aortic Valve Stenosis; Clopidogrel; Coronary Angiography; Female; Four-Dimensional Computed Tomography; Heart Valve Prosthesis; Humans; Phenprocoumon; Platelet Aggregation Inhibitors; Prosthesis Failure; Thrombosis; Ticlopidine; Transcatheter Aortic Valve Replacement | 2015 |
Dual antiplatelet therapy use by Canadian cardiac surgeons.
Topics: Adenosine; Aspirin; Canada; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Ticagrelor; Ticlopidine | 2015 |
CYP2C19 genotype plus platelet reactivity-guided antiplatelet therapy in acute coronary syndrome patients: a decision analysis.
Topics: Acute Coronary Syndrome; Adenosine; Alleles; Blood Platelets; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Decision Support Techniques; Drug Costs; Genotype; Health Care Costs; Heterozygote; Humans; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticagrelor; Ticlopidine | 2015 |
Economic outcomes with prasugrel versus clopidogrel in acute coronary syndrome patients: observations from prasugrel users and matched clopidogrel users.
Topics: Acute Coronary Syndrome; Aged; Bayes Theorem; Clopidogrel; Costs and Cost Analysis; Female; Health Care Costs; Health Services; Humans; Insurance Claim Review; Logistic Models; Male; Markov Chains; Monte Carlo Method; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Propensity Score; Retrospective Studies; Ticlopidine | 2015 |
Platelet function recovery following exposure to triple anti-platelet inhibitors using an in vitro transfusion model.
Topics: Apoptosis Regulatory Proteins; Arachidonic Acid; Aspirin; Blood Platelets; Blood Transfusion; Clopidogrel; Flow Cytometry; Hemorrhage; Humans; Lactones; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Transfusion; Purinergic P2Y Receptor Antagonists; Pyridines; Receptors, Proteinase-Activated; Receptors, Purinergic P2Y12; Ticlopidine | 2015 |
Low-dose adjunctive cilostazol in patients with complex lesions undergoing percutaneous coronary intervention.
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Coronary Disease; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Safety; Tetrazoles; Ticlopidine; Treatment Outcome | 2016 |
Microvascular integrity plays an important role for graft survival after experimental skin transplantation.
Topics: Allografts; Animals; Clopidogrel; Drug Therapy, Combination; Everolimus; Graft Rejection; Graft Survival; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microvessels; Neovascularization, Physiologic; Platelet Aggregation Inhibitors; Skin Transplantation; Ticlopidine | 2015 |
Liver Function is Associated With Response to Clopidogrel Therapy in Patients Undergoing Angioplasty and Stenting.
Topics: Aged; Biomarkers; Blood Platelets; Cholesterol; Cholinesterases; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Liver; Liver Function Tests; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Serum Albumin, Human; Stents; Ticlopidine; Treatment Outcome | 2016 |
Point-of-care genetic profiling and/or platelet function testing in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Alleles; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Testing; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Testing; Prasugrel Hydrochloride; Prospective Studies; Receptors, Purinergic P2Y12; Reproducibility of Results; Ticlopidine | 2016 |
Platelet Larger Cell Ratio and High-on Treatment Platelet Reactivity During Dual Antiplatelet Therapy.
Topics: Adenosine; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine | 2015 |
Changes in platelet function independent of pharmacotherapy following coronary intervention in non-ST-elevation myocardial infarction patients.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Blood Platelets; Chromatography, Liquid; Clopidogrel; Electrodes; Female; Flow Cytometry; Humans; Luminescence; Male; Mass Spectrometry; Middle Aged; Myocardial Infarction; P-Selectin; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Tandem Mass Spectrometry; Ticlopidine | 2015 |
Aspirin and clopidogrel during robotic partial nephrectomy, is it safe?
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Clopidogrel; Feasibility Studies; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Nephrectomy; Patient Selection; Perioperative Period; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Robotic Surgical Procedures; Ticlopidine; Withholding Treatment | 2015 |
Personalized ADP-receptor inhibition strategy and outcomes following primary PCI for STEMI (PASTOR study).
Topics: Aged; Antithrombins; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Precision Medicine; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2016 |
An Infected Aneurysm of the Vertebral Artery Treated with a Stent-graft: A Case Report.
Topics: Aged; Aneurysm, Infected; Angiography; Aspirin; Clopidogrel; Drug Combinations; Humans; Male; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Tomography, X-Ray Computed; Vertebral Artery | 2015 |
Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics.
Topics: Clopidogrel; Ethnicity; Genetic Markers; Genetic Variation; Genetics, Population; Humans; Pharmacogenetics; Principal Component Analysis; Sri Lanka; Ticlopidine; Warfarin | 2016 |
Prior chronic clopidogrel therapy is associated with increased adverse events and early stent thrombosis.
Topics: Acute Coronary Syndrome; Aged; Cardiovascular Diseases; Clopidogrel; Comorbidity; Coronary Artery Bypass; Female; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Stents; Stroke; Surveys and Questionnaires; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60-year-old Caucasian woman with ovarian carcinoma.
Topics: Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Drug Interactions; Female; Humans; Middle Aged; Neurotoxicity Syndromes; Ovarian Neoplasms; Paclitaxel; Ticlopidine | 2016 |
Predicting Bleeding Risk by Platelet Function Testing in Patients Undergoing Heart Surgery.
Topics: Adult; Aged; Aged, 80 and over; Area Under Curve; Aspirin; Blood Loss, Surgical; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Drug Administration Schedule; Drug Therapy, Combination; Erythrocyte Transfusion; Female; Heart Valve Prosthesis Implantation; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; ROC Curve; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2015 |
Is Extended Duration of Dual Antiplatelet Therapy After Carotid Stenting Beneficial?
Topics: Aged; Aspirin; Carotid Arteries; Carotid Stenosis; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Stents; Stroke; Ticlopidine | 2015 |
Japanese postmarketing surveillance of clopidogrel in patients with non-ST-segment elevation acute coronary syndrome, stable angina, old myocardial infarction, and ST-segment elevation myocardial infarction after percutaneous coronary intervention in a re
Topics: Acute Coronary Syndrome; Adolescent; Adult; Aged; Angina, Stable; Asian People; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Product Surveillance, Postmarketing; Ticlopidine; Treatment Outcome; Young Adult | 2016 |
A deceitful stroke, a hidden tumour.
Topics: Adult; Brain Neoplasms; Clopidogrel; Decompressive Craniectomy; Delayed Diagnosis; Female; Humans; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Radiotherapy; Ticlopidine; Tomography, X-Ray Computed | 2015 |
Rapid and portable, lab-on-chip, point-of-care genotyping for evaluating clopidogrel metabolism.
Topics: Acute Coronary Syndrome; Alleles; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Lab-On-A-Chip Devices; Point-of-Care Systems; Polymorphism, Genetic; Ticlopidine | 2015 |
Severe Cutaneous Bleeding: An Unusual Complication of Dual Antiplatelet Therapy.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Ecchymosis; Female; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
PHILO -- ensuring trial results are not lost in translation.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2015 |
A new approach: Left atrial appendage occlusion, as an alternative to anticoagulant, to treat patient who suffered of atrial fibrillation, acute coronary syndrome and clopidogrel resistance.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Drug Resistance; Female; Humans; Radiography; Ticlopidine; Treatment Outcome; Ultrasonography | 2016 |
A New Protocol for Anticoagulation With Tirofiban During Flow Diversion.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clinical Protocols; Clopidogrel; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Intracranial Aneurysm; Intracranial Hemorrhages; Intraoperative Care; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Tirofiban; Tyrosine | 2016 |
A tablet of clopidogrel remaining in the lower esophagus after primary percutaneous coronary intervention for acute myocardial infarction.
Topics: Aged; Clopidogrel; Combined Modality Therapy; Esophagus; Female; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Tablets; Ticlopidine | 2015 |
Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Cilostazol; Clopidogrel; Diabetes Mellitus; Drug Resistance; Drug Therapy, Combination; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation; Platelet Aggregation Inhibitors; Premedication; Prospective Studies; Purinergic P2Y Receptor Antagonists; Smoking; Stents; Tetrazoles; Ticlopidine | 2016 |
Successful Prasugrel Therapy for Recurrent Left Main Stent Thrombosis in a Clopidogrel Hyporesponder.
Topics: Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Thrombosis; Drug Resistance; Drug Substitution; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prosthesis Design; Recurrence; Ticlopidine; Time Factors; Treatment Outcome | 2015 |
Advanced age and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor.
Topics: Adenosine; Adenosine Diphosphate; Age Factors; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Odds Ratio; Patient Discharge; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prevalence; Thrombosis; Ticagrelor; Ticlopidine; Time Factors | 2016 |
Endoscopic ultrasound-guided fine-needle aspiration of solid lesions on clopidogrel may not be a high-risk procedure for bleeding: A case series.
Topics: Aged; Clopidogrel; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Endoscopy, Gastrointestinal; Endosonography; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Thrombosis; Ticlopidine | 2016 |
Safety of prasugrel in real-world patients with ST-segment elevation myocardial infarction: 1-year results from a prospective observational study (Bleeding and Myocardial Infarction Study).
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Registries; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.
Topics: Adenocarcinoma; Animals; Blood Platelets; Cell Line, Tumor; Cell-Derived Microparticles; Clopidogrel; Female; Flow Cytometry; Humans; Mice; Mice, Inbred C57BL; Neoplasms; Pancreatic Neoplasms; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Thrombin; Thromboplastin; Thrombosis; Ticlopidine | 2016 |
Platelet reactivity in patients with impaired renal function receiving dual antiplatelet therapy with clopidogrel or ticagrelor.
Topics: Adenosine; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Renal Insufficiency, Chronic; Ticagrelor; Ticlopidine | 2016 |
Comparison of VerifyNow P2Y12 and thrombelastography for assessing clopidogrel response in stroke patients in China.
Topics: Adenosine Diphosphate; Aged; Brain Ischemia; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Stroke; Thrombelastography; Ticlopidine | 2016 |
Impact of atorvastatin or rosuvastatin co-administration on platelet reactivity in patients treated with dual antiplatelet therapy.
Topics: Adenosine; Aged; Aspirin; Atorvastatin; Chi-Square Distribution; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polypharmacy; Risk Assessment; Risk Factors; Rosuvastatin Calcium; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
Very late scaffold thrombosis of everolimus-eluting bioresorbable scaffold following implantation in STEMI after discontinuation of dual antiplatelet therapy.
Topics: Absorbable Implants; Adult; Clopidogrel; Coronary Angiography; Coronary Thrombosis; Coronary Vessels; Drug-Eluting Stents; Everolimus; Humans; Immunosuppressive Agents; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Prosthesis Design; ST Elevation Myocardial Infarction; Ticlopidine; Tissue Scaffolds; Withholding Treatment | 2017 |
Correlation between the CYP2C19 phenotype status and the results of three different platelet function tests in cardiovascular disease patients receiving antiplatelet therapy: an emphasis on newly introduced platelet function analyzer-200 P2Y test.
Topics: Aged; Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Ticlopidine | 2016 |
Comparison of antiplatelet regimens in secondary stroke prevention: a nationwide cohort study.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Cohort Studies; Denmark; Dipyridamole; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Recurrence; Registries; Secondary Prevention; Stroke; Ticlopidine | 2015 |
Ticagrelor vs. clopidogrel in non-ST-elevation acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Bradycardia; Clopidogrel; Comorbidity; Electrocardiography; Female; Germany; Humans; Male; Non-ST Elevated Myocardial Infarction; Prevalence; Purinergic P2Y Receptor Antagonists; Risk Factors; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
[A case review: About a STEMI in the very elderly].
Topics: Aged, 80 and over; Aging; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Clopidogrel; Drug Therapy, Combination; Female; Heparin; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2015 |
Effect of CYP2C19 Polymorphisms on the Platelet Response to Clopidogrel and Influence on the Effect of High Versus Standard Dose Clopidogrel in Carotid Artery Stenting.
Topics: Aged; Angioplasty; Blood Platelets; Carotid Artery Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Endobronchial Ultrasound-guided Transbronchial Needle Aspiration while Receiving Aspirin and Clopidogrel: Is It Always Safe?
Topics: Aspirin; Clopidogrel; Contraindications; Echocardiography, Doppler, Color; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Female; Hemorrhage; Humans; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in
Topics: Animals; Carboxylic Acids; Clopidogrel; Dogs; Drug Discovery; Esterification; Humans; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Purinergic P2Y Receptor Antagonists; Pyrrolidines; Rats; Rats, Wistar; Thrombosis; Ticlopidine | 2015 |
Antiplatelet effects of clopidogrel and aspirin after interventional patent foramen ovale/ atrium septum defect closure.
Topics: Adult; Aged; Aspirin; Blood Platelets; Cardiac Surgical Procedures; Clopidogrel; Comorbidity; Female; Follow-Up Studies; Foramen Ovale, Patent; Hemorrhage; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Care; Preoperative Care; Risk Factors; Ticlopidine; Treatment Outcome | 2016 |
Switching from prasugrel to clopidogrel based on Cytochrome P450 2C19 genotyping in East Asian patients stabilized after acute myocardial infarction.
Topics: Aged; Alleles; Asian People; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Substitution; Female; Genotype; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenomic Variants; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticlopidine | 2016 |
Case report: Haematomas.
Topics: Aged; Clopidogrel; Female; Hematoma; Humans; Platelet Aggregation Inhibitors; Root Canal Therapy; Ticlopidine; Trinidad and Tobago | 2015 |
Metabolic Interaction Potential between Clopidogrel and Sulfonylurea Antidiabetic Agents: Effects on Clopidogrel Bioactivation.
Topics: Carboxylic Ester Hydrolases; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9 Inhibitors; Dose-Response Relationship, Drug; Drug Antagonism; Gliclazide; Glipizide; Humans; Hypoglycemic Agents; Intestines; Liver; Microsomes; Sulfonylurea Compounds; Ticlopidine | 2016 |
Impact of Cytochrome P450 2C19*2 and *3 on Clopidogrel Loading Dose in Saudi Patients with Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Coronary Thrombosis; Cytochrome P-450 CYP2C19; Drug Dosage Calculations; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Prospective Studies; Saudi Arabia; Sex Factors; Ticlopidine; Treatment Outcome | 2016 |
Relationship between pharmacokinetics and pharmacodynamics of clopidogrel in patients undergoing percutaneous coronary intervention: comparison between vasodilator-stimulated phosphoprotein phosphorylation assay and multiple electrode aggregometry.
Topics: Acute Coronary Syndrome; Adult; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Monitoring; Female; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Percutaneous Coronary Intervention; Phenotype; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Reproducibility of Results; Ticlopidine; Treatment Outcome | 2016 |
It Is Not Mandatory to Use Triple Rather Than Dual Anti-Platelet Therapy After a Percutaneous Coronary Intervention With a Second-Generation Drug-Eluting Stent.
Topics: Adult; Aged; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Everolimus; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Registries; Sirolimus; Tetrazoles; Thrombosis; Ticlopidine; Treatment Outcome | 2015 |
Relationship between Inflammation and Aspirin and Clopidogrel Antiplatelet Responses in Acute Ischemic Stroke.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Biomarkers; Brain Ischemia; CD40 Ligand; Clopidogrel; Female; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Matrix Metalloproteinase 9; Middle Aged; P-Selectin; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticlopidine | 2016 |
CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.
Topics: Aged; Aspirin; Carboxylic Ester Hydrolases; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotyping Techniques; Heterozygote; Humans; Intracranial Arteriosclerosis; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prospective Studies; Stroke; Ticlopidine | 2016 |
Insufficient platelet inhibition and thromboembolic complications in patients with intracranial aneurysms after stent placement.
Topics: Adult; Aged; Aspirin; Clopidogrel; Drug Resistance; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Stents; Thromboembolism; Ticlopidine | 2016 |
Current Antiplatelet Agents in Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticagrelor; Ticlopidine; Treatment Outcome | 2015 |
What are the precautions with proton pump inhibitor use for reflux disease?
Topics: Anemia, Iron-Deficiency; Clopidogrel; Community-Acquired Infections; Deficiency Diseases; Drug Interactions; Enterocolitis, Pseudomembranous; Fractures, Bone; Gastroesophageal Reflux; Humans; Magnesium Deficiency; Pneumonia; Proton Pump Inhibitors; Ticlopidine; Vitamin B 12 Deficiency | 2015 |
Concomitant nitrates enhance clopidogrel response during dual anti-platelet therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nitrates; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Time Factors; Treatment Outcome; Young Adult | 2016 |
Stent thrombosis after primary percutaneous coronary intervention in comatose survivors of out-of-hospital cardiac arrest: Are the new P2Y12 inhibitors really more effective than clopidogrel?
Topics: Adenosine; Aspirin; Clopidogrel; Coma; Coronary Angiography; Coronary Thrombosis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Retrospective Studies; Risk Factors; Stents; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Enhancement of Dissolution Rate and Intestinal Stability of Clopidogrel Hydrogen Sulfate.
Topics: Animals; Biotransformation; Cellulose; Clopidogrel; Colon; Drug Compounding; Drug Liberation; Drug Stability; Emulsifying Agents; Excipients; Fats; In Vitro Techniques; Intestinal Mucosa; Intestinal Secretions; Intestine, Small; Micelles; Oils; Pharmaceutical Vehicles; Platelet Aggregation Inhibitors; Polyethylene Glycols; Prodrugs; Rabbits; Silicon Dioxide; Suspensions; Ticlopidine | 2016 |
Determinants of pre-hospital pharmacological intervention and its association with outcome in acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Aged; Analgesics, Opioid; Anticoagulants; Aspirin; Clopidogrel; Electrocardiography; Emergency Medical Services; Female; Humans; Male; Morphine; Myocardial Infarction; Nitroglycerin; Oxygen; Platelet Aggregation Inhibitors; Sweden; Ticlopidine; Treatment Outcome; Vasodilator Agents | 2015 |
A prognostic model based on readily available clinical data enriched a pre-emptive pharmacogenetic testing program.
Topics: Adult; Age Factors; Aged; Clopidogrel; Decision Support Systems, Clinical; Drug Utilization; Electronic Health Records; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Longitudinal Studies; Male; Middle Aged; Models, Statistical; Pharmacogenetics; Predictive Value of Tests; Prognosis; Program Evaluation; Proportional Hazards Models; Reproducibility of Results; Risk Factors; Sex Factors; Ticlopidine; United States; Warfarin | 2016 |
Physician perspectives of CYP2C19 and clopidogrel drug-gene interaction active clinical decision support alerts.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Clopidogrel; Cytochrome P-450 CYP2C19; Decision Support Systems, Clinical; Drug Interactions; Drug Therapy, Computer-Assisted; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Medical Order Entry Systems; Medication Errors; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Reminder Systems; Ticlopidine; User-Computer Interface; Young Adult | 2016 |
Low On-Treatment Platelet Reactivity Predicts Long-Term Risk of Bleeding After Elective PCI.
Topics: Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Predictive Value of Tests; Prospective Studies; Risk; Ticlopidine; Time Factors | 2015 |
[Stent-Assisted Coil Embolization of a Dissecting Aneurysm of the Posterior Cerebral Artery: A Case Report].
Topics: Aortic Dissection; Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Fibrinolytic Agents; Humans; Intracranial Aneurysm; Middle Aged; Posterior Cerebral Artery; Stents; Ticlopidine | 2015 |
Aspirin in the prevention of cardiovascular events in patients with diabetes.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Diabetes Complications; Diabetes Mellitus; Drug Administration Schedule; Half-Life; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
The mechanism and risk factors of clopidogrel-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Hep G2 Cells; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Mice, Inbred Strains; Models, Biological; Platelet Aggregation Inhibitors; Rats, Wistar; Reactive Oxygen Species; Risk Factors; Ticlopidine | 2016 |
[Association of CYP2C19 gene polymorphisms with long-term recurrent risk of ischemic stroke among ethnic Han Chinese from Fujian].
Topics: Aged; Alleles; Asian People; Brain Ischemia; China; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Recurrence; Risk Factors; Sequence Analysis, DNA; Stroke; Ticlopidine; Time Factors | 2015 |
Percutaneous left atrial appendage occlusion: Device thrombosis in clopidogrel non-responders.
Topics: Aged; Aged, 80 and over; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Female; Heart Diseases; Humans; Male; Middle Aged; Prosthesis Implantation; Thrombosis; Ticlopidine; Treatment Outcome; Ultrasonography | 2016 |
Cochlear Implantation in the Setting of Perioperative Anticoagulation and Antiplatelet Therapy.
Topics: Aged; Anticoagulants; Aspirin; Blood Loss, Surgical; Clopidogrel; Cochlear Implantation; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Ticlopidine; Treatment Outcome; Warfarin | 2016 |
Bioequivalence of clopidogrel hydrogen sulfate tablets in healthy Chinese volunteers.
Topics: Adult; Biological Availability; Chromatography, Liquid; Clopidogrel; Drug Monitoring; Drug Stability; Healthy Volunteers; Humans; Reproducibility of Results; Tablets; Tandem Mass Spectrometry; Ticlopidine; Young Adult | 2015 |
Clopidogrel-induced refractory thrombotic thrombocytopenic purpura successfully treated with rituximab.
Topics: ADAMTS13 Protein; Adult; Clopidogrel; Female; Humans; L-Lactate Dehydrogenase; Platelet Count; Purpura, Thrombotic Thrombocytopenic; Rituximab; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Prospective Benefit-Risk Monitoring of New Drugs for Rapid Assessment of Net Favorability in Electronic Health Care Data.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Bone Density Conservation Agents; Clopidogrel; Denosumab; Humans; Information Systems; Lactones; Prasugrel Hydrochloride; Product Surveillance, Postmarketing; Prospective Studies; Quality-Adjusted Life Years; Risk Assessment; Sulfones; Ticlopidine | 2015 |
Physician response to implementation of genotype-tailored antiplatelet therapy.
Topics: Age Factors; Aged; Clinical Decision-Making; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Precision Medicine; Prospective Studies; Stents; Ticlopidine | 2016 |
Platelet reactivity in patients undergoing transcatheter aortic valve implantation.
Topics: Aged; Aged, 80 and over; Aortic Valve Stenosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Platelet Activation; Platelet Aggregation Inhibitors; Thromboembolism; Ticlopidine; Transcatheter Aortic Valve Replacement; Warfarin | 2016 |
Dual platelet inhibition in cases of severe retrobulbar hemorrhage following retrobulbar and peribulbar anesthesia.
Topics: Aged; Anesthesia, Local; Anticoagulants; Arterial Occlusive Diseases; Aspirin; Cardiac Surgical Procedures; Cardiovascular Diseases; Clopidogrel; Drug Combinations; Female; Humans; Lens Implantation, Intraocular; Male; Phacoemulsification; Platelet Aggregation Inhibitors; Retrobulbar Hemorrhage; Retrospective Studies; Risk Factors; Ticlopidine; Warfarin | 2015 |
Acute Coronary Syndromes, Gastrointestinal Protection, and Recommendations Regarding Concomitant Administration of Proton-Pump Inhibitors (Omeprazol/Esomeprazole) and Clopidogrel.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Esomeprazole; Female; Gastrointestinal Diseases; Humans; Male; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2016 |
[Impact of preoperative dual antiplatelet therapy on perioperative bleeding in patients undergoing off-pump coronary artery bypass grafting].
Topics: Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass, Off-Pump; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2015 |
Interleukin-10 does not modulate clopidogrel platelet response in mice.
Topics: Activation, Metabolic; Animals; Area Under Curve; Blood Platelets; Clopidogrel; Genotype; Interleukin-10; Metabolic Clearance Rate; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2016 |
Premature Clopidogrel Discontinuation After Drug-Eluting Stent Placement in a Large Urban Safety-Net Hospital.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Follow-Up Studies; Hospitals, Urban; Humans; Male; Middle Aged; Patient Compliance; Postoperative Period; Prognosis; Retrospective Studies; Ticlopidine; Time Factors; Withholding Treatment | 2016 |
Clinical Value of CYP2C19 Genetic Testing for Guiding the Antiplatelet Therapy in a Chinese Population.
Topics: Adenosine; Aged; Aged, 80 and over; Asian People; Biotransformation; Chi-Square Distribution; China; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Monitoring; Female; Genotype; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Pharmacogenomic Testing; Phenotype; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Changes in Practice Patterns of Clopidogrel in Combination with Proton Pump Inhibitors after an FDA Safety Communication.
Topics: Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Patient Safety; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proton Pump Inhibitors; Ticlopidine; United States; United States Food and Drug Administration | 2016 |
Is There an Ideal Level of Platelet P2Y12-Receptor Inhibition in Patients Undergoing Percutaneous Coronary Intervention?: "Window" Analysis From the ADAPT-DES Study (Assessment of Dual AntiPlatelet Therapy With Drug-Eluting Stents).
Topics: Aged; Aspirin; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Disease; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Germany; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; United States | 2015 |
Effect of atorvastatin co-treatment on inhibition of platelet activation by clopidogrel in patients with ischemic stroke.
Topics: Aged; Atorvastatin; Brain Ischemia; Clopidogrel; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Platelet Activation; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2015 |
Ticagrelor in Triple Antithrombotic Therapy: Predictors of Ischemic and Bleeding Complications.
Topics: Adenosine; Chi-Square Distribution; Clinical Trials as Topic; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Hemorrhage; Humans; Logistic Models; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Prolonged Clopidogrel Use is Associated with Improved Clinical Outcomes Following Drug-Eluting But Not Bare Metal Stent Implantation.
Topics: Clopidogrel; Drug-Eluting Stents; Female; Humans; Male; Metals; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Gambogic acid potentiates clopidogrel-induced apoptosis and attenuates irinotecan-induced apoptosis through down-regulating human carboxylesterase 1 and -2.
Topics: Antineoplastic Agents; Apoptosis; Biotransformation; Camptothecin; Carboxylesterase; Clopidogrel; Down-Regulation; Irinotecan; Ticlopidine; Xanthones | 2016 |
Factors influencing platelet reactivity in patients undergoing coronary artery bypass surgery.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Clopidogrel Versus Aspirin as an Antiplatelet Monotherapy After 12-Month Dual-Antiplatelet Therapy in the Era of Drug-Eluting Stents.
Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug-Eluting Stents; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Proportional Hazards Models; Recurrence; Registries; Republic of Korea; Survival Rate; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier.
Topics: Animals; Blood-Brain Barrier; Cell Movement; Clopidogrel; Male; Mice; Mice, Inbred C57BL; Microglia; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Ticlopidine | 2016 |
Genetic and Nongenetic Factors Affecting Clopidogrel Response in the Egyptian Population.
Topics: Cardiovascular Diseases; Clopidogrel; Demography; Egypt; Ethnicity; Female; Gene Frequency; Humans; Logistic Models; Male; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Ticlopidine; Treatment Outcome | 2016 |
Risk of early recurrent stroke in symptomatic carotid stenosis after best medical therapy and before endarterectomy.
Topics: Aged; Aged, 80 and over; Aspirin; Carotid Arteries; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Fibrinolytic Agents; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Middle Aged; New Zealand; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Risk; Stroke; Ticlopidine; Time Factors | 2016 |
High on-aspirin platelet reactivity predicts cardiac death in acute coronary syndrome patients undergoing PCI.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Death; Drug-Eluting Stents; Female; Humans; Italy; Kaplan-Meier Estimate; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine | 2016 |
[Computational Pharmacological Study on Clopidogrel Metabolism Enzymes Influenced by Fufang Danshen Dripping Pill].
Topics: Clopidogrel; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Humans; Ticlopidine | 2015 |
Assessment of platelet-derived thrombogenicity with the total thrombus-formation analysis system in coronary artery disease patients receiving antiplatelet therapy.
Topics: Aged; Area Under Curve; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cross-Sectional Studies; Cytochrome P-450 CYP2C19; Electrocardiography; Female; Genotype; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2016 |
Late Major Hemoptysis After Lung Volume Reduction With Coils Induced by Dual Antiaggregation Therapy.
Topics: Aspirin; Clopidogrel; Hemoptysis; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Pneumonectomy; Postoperative Complications; Pulmonary Emphysema; Severity of Illness Index; Ticlopidine; Time Factors | 2016 |
Spontaneous coronary artery dissection in the presence of myocardial bridge causing myocardial infarction: an insight into mechanism.
Topics: Adult; Aspirin; Atorvastatin; Clopidogrel; Coronary Angiography; Coronary Vessel Anomalies; Female; Humans; Myocardial Bridging; Myocardial Infarction; Perindopril; Ticlopidine; Treatment Outcome; Vascular Diseases | 2016 |
Resource use and costs in high-risk symptomatic peripheral artery disease patients with diabetes and prior acute coronary syndrome: a retrospective analysis.
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Clopidogrel; Costs and Cost Analysis; Diabetic Angiopathies; Female; Health Resources; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Longitudinal Studies; Male; Peripheral Arterial Disease; Retrospective Studies; Risk Factors; Ticlopidine; United States | 2016 |
Influence of platelet reactivity on BARC classification in East Asian patients undergoing percutaneous coronary intervention. Results of the ACCEL-BLEED study.
Topics: Aged; Asia, Eastern; Asian People; Aspirin; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Hemorrhage; Humans; Male; Microfilament Proteins; Middle Aged; Percutaneous Coronary Intervention; Phosphoproteins; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine; Time Factors | 2016 |
Treatment with Clopidogrel Prior to Acute Non-Cardioembolic Ischemic Stroke Attenuates Stroke Severity.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Chi-Square Distribution; Clopidogrel; Disability Evaluation; Female; Hospital Mortality; Humans; Logistic Models; Male; Odds Ratio; Patient Admission; Patient Discharge; Platelet Aggregation Inhibitors; Prospective Studies; Protective Factors; Recovery of Function; Risk Factors; Severity of Illness Index; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Clopidogrel Use as Single Antiplatelet Therapy in Outpatients with Stable Coronary Artery Disease: Prevalence, Correlates and Association with Prognosis (from the CORONOR Study).
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Endovascular Procedures; Female; France; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Outcome and Process Assessment, Health Care; Outpatients; Platelet Aggregation Inhibitors; Prevalence; Prognosis; Registries; Stroke; Ticlopidine | 2016 |
Triple vs Dual Antithrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Comorbidity; Coronary Artery Disease; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hospitalization; Humans; Male; Markov Chains; Monte Carlo Method; Myocardial Infarction; Outcome and Process Assessment, Health Care; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Pyridines; Registries; Stroke; Ticlopidine; Warfarin | 2016 |
Impact of Triple Therapy in Elderly Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Risk Factors; Ticlopidine | 2016 |
Continuation and adherence rates on initially-prescribed intensive secondary prevention therapy after Rapid Access Stroke Prevention (RASP) service assessment.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Aspirin; Brain Ischemia; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Female; Humans; Incidence; Male; Medication Adherence; Middle Aged; Recurrence; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome; Warfarin; Young Adult | 2016 |
Usefulness of Intravascular Ultrasound for Predicting Risk of Intraprocedural Stent Thrombosis.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Humans; Japan; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Sensitivity and Specificity; Stents; Thrombosis; Ticlopidine; Ultrasonography, Interventional | 2016 |
Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway.
Topics: AMP-Activated Protein Kinases; Anti-Inflammatory Agents; Antioxidants; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Adhesion; Clopidogrel; Endothelial Cells; Glutathione; Heme Oxygenase-1; HL-60 Cells; Humans; Leukocytes; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; RNA Interference; Signal Transduction; Ticlopidine; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2016 |
Association between high on-treatment platelet reactivity and occurrence of cerebral ischemic events in patients undergoing percutaneous coronary intervention.
Topics: Adult; Aged; Aged, 80 and over; Blood Platelets; Brain Ischemia; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Risk Factors; Ticlopidine | 2016 |
The Importance of the Mean Platelet Aggregation Degree in Long-term Dual Antiplatelet Therapy Following Drug-Eluting Stent Implantation.
Topics: Aged; Aspirin; Chi-Square Distribution; Clopidogrel; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proportional Hazards Models; Registries; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Effects of genetic factors to stent thrombosis due to clopidogrel resistance after coronary stent placement.
Topics: Blood Platelets; Case-Control Studies; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Genotype; Humans; Male; Middle Aged; Mutation; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2016 |
Decision making on timing of surgery for hip fracture patients on clopidogrel.
Topics: Aged, 80 and over; Blood Transfusion; Clopidogrel; Contraindications; Decision Making; Female; Hemoglobins; Hip Fractures; Humans; Length of Stay; Male; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Likelihood ratio meta-analysis: New motivation and approach for an old method.
Topics: Aspirin; Bayes Theorem; Clopidogrel; Data Interpretation, Statistical; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Likelihood Functions; Meta-Analysis as Topic; Models, Statistical; Myocardial Infarction; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Stroke; Ticlopidine; Treatment Outcome | 2016 |
Spinal subarachnoid hemorrhage in cortical superficial siderosis after apixaban and clopidogrel therapy.
Topics: Aged; Clopidogrel; Hematoma, Subdural, Spinal; Humans; Magnetic Resonance Imaging; Male; Pyrazoles; Pyridones; Siderosis; Ticlopidine | 2016 |
Platelet reactivity after administration of third generation P2Y12-antagonists does not depend on body weight in contrast to clopidogrel.
Topics: Adenosine; Body Weight; Clopidogrel; Dose-Response Relationship, Drug; Drug Dosage Calculations; Humans; Platelet Activation; Platelet Aggregation; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2016 |
Prevalence and risk factors of clopidogrel non-response among Saudi patients undergoing coronary angiography.
Topics: Adult; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans; In Vitro Techniques; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Prevalence; Risk Factors; Saudi Arabia; Ticlopidine; Treatment Failure | 2016 |
Cost effectiveness of left atrial appendage closure with the Watchman device for atrial fibrillation patients with absolute contraindications to warfarin.
Topics: Anticoagulants; Aspirin; Atrial Appendage; Atrial Fibrillation; Cardiac Surgical Procedures; Clopidogrel; Contraindications; Cost-Benefit Analysis; Germany; Humans; Markov Chains; Models, Theoretical; Pyrazoles; Pyridones; Quality of Life; Quality-Adjusted Life Years; Stroke; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2016 |
Insulin autoimmune syndrome during the administration of clopidogrel.
Topics: Aged; Aged, 80 and over; Autoantibodies; Autoimmune Diseases; Blood Glucose; Clopidogrel; Glycated Hemoglobin; Humans; Hypoglycemia; Insulin Antibodies; Male; Molecular Structure; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2016 |
Access-site bleeding and radial artery occlusion in transradial primary percutaneous coronary intervention: influence of adjunctive antiplatelet therapy.
Topics: Abciximab; Adenosine; Aged; Antibodies, Monoclonal; Catheterization, Peripheral; Clopidogrel; Female; Hematoma; Hemorrhage; Hemostatic Techniques; Humans; Immunoglobulin Fab Fragments; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Punctures; Purinergic P2Y Receptor Antagonists; Radial Artery; Risk Factors; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Uric acid and high-residual platelet reactivity in patients treated with clopidogrel or ticagrelor.
Topics: Adenosine; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Fibrinogen; Humans; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticagrelor; Ticlopidine; Triglycerides; Uric Acid | 2016 |
The Antiplatelet Effect of Clopidogrel Decreases With Patient Age.
Topics: Adenosine Diphosphate; Age Factors; Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Flow Cytometry; Humans; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Ticlopidine; Treatment Outcome | 2016 |
Gender Differences in Platelet Reactivity in Patients Receiving Dual Antiplatelet Therapy.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Sex Characteristics; Ticagrelor; Ticlopidine | 2016 |
The Impact of CYP2C19 Loss-of-Function Polymorphisms, Clinical, and Demographic Variables on Platelet Response to Clopidogrel Evaluated Using Impedance Aggregometry.
Topics: Acute Coronary Syndrome; Aspirin; Blood Platelets; Cardiography, Impedance; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Drug Synergism; Europe, Eastern; Genotype; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prevalence; Stroke; Ticlopidine | 2017 |
Time-Varying Effects of Prasugrel Versus Clopidogrel on the Long-Term Risks of Stroke After Acute Coronary Syndromes: Results From the TRILOGY ACS Trial.
Topics: Acute Coronary Syndrome; Aged; Brain Ischemia; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Risk; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Impact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel.
Topics: Aged; Alleles; Body Mass Index; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2017 |
Relationship Between Platelet Reactivity and Culprit Lesion Morphology: An Assessment From the ADAPT-DES Intravascular Ultrasound Substudy.
Topics: Aged; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Vessels; Drug Resistance; Drug-Eluting Stents; Female; Fibrosis; Germany; Humans; Least-Squares Analysis; Logistic Models; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Plaque, Atherosclerotic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; Ultrasonography, Interventional; United States | 2016 |
Antiplatelet Therapy in TAVI: Current Clinical Practice and Recommendations.
Topics: Administration, Oral; Anticoagulants; Aortic Valve Stenosis; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Transcatheter Aortic Valve Replacement | 2016 |
Clopidogrel, prasugrel or ticagrelor in patients with acute coronary syndromes undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Australia; Clopidogrel; Comorbidity; Female; Hemorrhage; Humans; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Self-Powered Microfluidic Device for Rapid Assay of Antiplatelet Drugs.
Topics: Abciximab; Adenosine; Adenosine Monophosphate; Animals; Antibodies, Monoclonal; Cattle; Clopidogrel; Dimethylpolysiloxanes; Equipment Design; Fibrinogen; Humans; Immunoglobulin Fab Fragments; Lab-On-A-Chip Devices; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Powders; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Serum Albumin, Bovine; Ticagrelor; Ticlopidine | 2016 |
Visualization and quantification of deformation behavior of clopidogrel bisulfate polymorphs during tableting.
Topics: Clopidogrel; Compressive Strength; Crystallization; Drug Compounding; Microscopy, Electron, Scanning; Pressure; Tablets; Ticlopidine; X-Ray Diffraction; X-Ray Microtomography | 2016 |
Comparison of Three Tests to Distinguish Platelet Reactivity in Patients with Renal Impairment during Dual Antiplatelet Therapy.
Topics: Aged; Aspirin; Clopidogrel; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Hemorrhage; Humans; Kidney Diseases; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Thrombosis; Ticlopidine | 2016 |
Effect of preanalytical time-delay on platelet function as measured by multiplate, PFA-100 and VerifyNow.
Topics: Aged; Blood Platelets; Case-Control Studies; Clopidogrel; Humans; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Ticlopidine; Time Factors | 2016 |
Clopidogrel pharmacokinetics and pharmacodynamics in out-of-hospital cardiac arrest patients with acute coronary syndrome undergoing target temperature management.
Topics: Acute Coronary Syndrome; Aged; Cardiopulmonary Resuscitation; Clopidogrel; Female; Follow-Up Studies; Humans; Hypothermia, Induced; Male; Out-of-Hospital Cardiac Arrest; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2016 |
[Impact of novel P2Y12 receptor inhibitors on platelet reactivity in acute coronary syndrome patients undergoing percutaneous coronary intervention].
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Ticagrelor; Ticlopidine | 2016 |
Clopidogrel Resistance Increases Rate of Recurrent Stroke and Other Vascular Events in Chinese Population.
Topics: Aged; Aged, 80 and over; Asian People; Chi-Square Distribution; China; Clopidogrel; Disability Evaluation; Drug Resistance; Female; Humans; Incidence; Logistic Models; Male; Middle Aged; Odds Ratio; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proportional Hazards Models; Prospective Studies; Recurrence; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Antiplatelet Therapy of Cilostazol or Sarpogrelate with Aspirin and Clopidogrel after Percutaneous Coronary Intervention: A Retrospective Cohort Study Using the Korean National Health Insurance Claim Database.
Topics: Aspirin; Cilostazol; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Hemorrhage; Humans; Insurance, Health; Korea; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Succinates; Tetrazoles; Ticlopidine; Treatment Outcome | 2016 |
Dual antiplatelet therapy reduces stroke but increases bleeding at the time of carotid endarterectomy.
Topics: Aged; Aspirin; Asymptomatic Diseases; Carotid Artery Diseases; Chi-Square Distribution; Clopidogrel; Comorbidity; Drug Administration Schedule; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Hemorrhage; Hospital Mortality; Humans; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Propensity Score; Protective Factors; Registries; Reoperation; Retrospective Studies; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome; United States | 2016 |
Impact of C34T P2Y12 ADP receptor polymorphism and smoking status on cardiovascular outcome in coronary artery disease patients receiving clopidogrel.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Polymorphism, Genetic; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Smoking; Ticlopidine; Treatment Outcome | 2016 |
Impact of diabetes on immature platelets fraction and its relationship with platelet reactivity in patients receiving dual antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Diabetes Mellitus; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine | 2016 |
Reversible cerebral vasoconstriction syndrome (RCVS): a transient condition being underdiagnosed?
Topics: Aged; Brain; Clopidogrel; Female; Headache; Humans; Hydroxyurea; Magnetic Resonance Angiography; Ticlopidine; Treatment Outcome; Vasospasm, Intracranial | 2016 |
Comparative resource utilization and costs for patients with acute coronary syndrome managed with percutaneous coronary intervention and treated with clopidogrel or prasugrel.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Databases, Factual; Disease Management; Female; Health Resources; Hemorrhage; Hospital Costs; Humans; Length of Stay; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2016 |
Advanced age and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor: comment.
Topics: Adenosine; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2016 |
Association of Cytochrome P450 Genetic Variants with Clopidogrel Resistance and Outcomes in Acute Ischemic Stroke.
Topics: Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Female; Humans; Ischemia; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Prospective Studies; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stroke; Ticlopidine | 2016 |
Dabigatran and rivaroxaban do not affect AA- and ADP-induced platelet aggregation in patients receiving concomitant platelet inhibitors.
Topics: Adenosine Diphosphate; Antithrombins; Arachidonic Acid; Clopidogrel; Dabigatran; Drug Therapy, Combination; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Rivaroxaban; Ticlopidine | 2016 |
Association of PEAR1 genetic variants with platelet reactivity in response to dual antiplatelet therapy with aspirin and clopidogrel in the Chinese patient population after percutaneous coronary intervention.
Topics: Aged; Asian People; Aspirin; Blood Platelets; China; Clopidogrel; Coronary Disease; Female; Haplotypes; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Ticlopidine | 2016 |
Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury.
Topics: Animals; Aorta; Clopidogrel; Disease Models, Animal; Endothelium, Vascular; Eptifibatide; Hirudin Therapy; Male; Mice; Mice, Inbred C57BL; Peptides; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Stress, Mechanical; Thrombosis; Ticlopidine | 2016 |
Flutamide-induced photoleukomelanoderma.
Topics: Administration, Cutaneous; Aged; Androgen Antagonists; Benzimidazoles; Biopsy; Biphenyl Compounds; Bisoprolol; Clopidogrel; Drug Eruptions; Eicosapentaenoic Acid; Ezetimibe; Flutamide; Glucocorticoids; Humans; Male; Patch Tests; Photosensitivity Disorders; Prostatic Neoplasms; Skin Pigmentation; Sunlight; Tetrazoles; Ticlopidine; Ursodeoxycholic Acid; Withholding Treatment | 2016 |
Hyper-Response to Clopidogrel in Japanese Patients Undergoing Transcatheter Aortic Valve Implantation.
Topics: Aged, 80 and over; Aortic Valve Stenosis; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Genotype; Humans; Japan; Male; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Postoperative Complications; Prognosis; Prospective Studies; Thrombosis; Ticlopidine; Transcatheter Aortic Valve Replacement | 2016 |
Bleeding after tooth extraction in patients taking aspirin and clopidogrel (Plavix®) compared with healthy controls.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Oral Hemorrhage; Platelet Aggregation Inhibitors; Ticlopidine; Tooth Extraction | 2016 |
Outcomes According to Cardiac Catheterization Referral and Clopidogrel Use Among Medicare Patients With Non-ST-Segment Elevation Myocardial Infarction Discharged Without In-hospital Revascularization.
Topics: Age Factors; Aged; Aged, 80 and over; Cardiac Catheterization; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Medicare; Myocardial Infarction; Myocardial Revascularization; Patient Discharge; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Referral and Consultation; Registries; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; United States | 2016 |
[Genetically determined variation in bioactivation of tamoxifen and clopidogrel].
Topics: Antineoplastic Agents; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Genetic Variation; Genotype; Humans; Tamoxifen; Ticlopidine | 2016 |
Impact of preoperative dual antiplatelet therapy on bleeding complications in patients with acute coronary syndromes who undergo urgent coronary artery bypass grafting.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Emergencies; Female; Humans; Japan; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Pyridines; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Effects of Arnica comp.-Heel® on reducing cardiovascular events in patients with stable coronary disease.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Middle Aged; Plants, Medicinal; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Retrospective Studies; Secondary Prevention; Tablets; Ticlopidine; Treatment Outcome | 2016 |
Contemporary antiplatelet treatment in acute coronary syndrome patients undergoing percutaneous coronary intervention: 1-year outcomes from the GReek AntiPlatElet (GRAPE) Registry.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Follow-Up Studies; Greece; Humans; Male; Middle Aged; Patient Safety; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Prospective Studies; Purinergic P2Y Receptor Antagonists; Registries; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Cangrelor Bridge Therapy for Gastroduodenal Biopsy.
Topics: Adenosine Monophosphate; Administration, Intravenous; Biopsy; Clopidogrel; Female; Gastrointestinal Hemorrhage; Humans; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2017 |
Trends in P2Y12 Inhibitor Use in Patients Referred for Invasive Evaluation of Coronary Artery Disease in Contemporary US Practice.
Topics: Adenosine; Adult; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Percutaneous Coronary Intervention; Practice Patterns, Physicians'; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Referral and Consultation; Retrospective Studies; Ticagrelor; Ticlopidine; United States | 2016 |
Comparison of Modified Impedance Whole Blood Platelet Aggregation Method Detecting Platelet Function in ACS Patients with Different CYP2C19 Genotypes.
Topics: Acute Coronary Syndrome; Adenosine Triphosphate; Adult; Aged; Automation, Laboratory; Biomarkers; Biotransformation; Blood Platelets; Calcium Chloride; Case-Control Studies; Cell Adhesion Molecules; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Monitoring; Electric Impedance; Female; Genotype; Humans; Male; Microfilament Proteins; Middle Aged; Pharmacogenetics; Phenotype; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Reproducibility of Results; Ticlopidine; Treatment Outcome; Young Adult | 2016 |
TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Clopidogrel; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Follow-Up Studies; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Recurrence; Stroke; Ticlopidine; TNF Receptor-Associated Factor 3 | 2016 |
Clinical Features and Outcomes of Diffuse Alveolar Hemorrhage During Antithrombotic Therapy: A Retrospective Cohort Study.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Cilostazol; Clopidogrel; Connective Tissue Diseases; Female; Fibrinolytic Agents; Heart Failure; Hemorrhage; Humans; Infections; Lung Diseases; Male; Middle Aged; Neoplasms; Pneumonia; Pulmonary Alveoli; Retrospective Studies; Survival Rate; Tetrazoles; Ticlopidine; Vasculitis; Warfarin | 2016 |
Another side effect of ticagrelor: Atrial fibrillation.
Topics: Adenosine; Aged; Angina, Unstable; Atrial Fibrillation; Clopidogrel; Humans; Male; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Dual Antiplatelet Therapy Beyond 1 Year Postinfarction: The Time Has Come and We're Beginning to Know Who Will Benefit.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Secondary Prevention; Ticagrelor; Ticlopidine; Time Factors | 2016 |
Safety of Continued Clopidogrel Use in the Preoperative Course of Gastrointestinal Surgery: A Retrospective Cohort Study.
Topics: Aged; Aged, 80 and over; Clopidogrel; Digestive System Surgical Procedures; Drug Administration Schedule; Female; Humans; Logistic Models; Longitudinal Studies; Male; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Propensity Score; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Withholding Treatment | 2017 |
Occurrence, causes, and outcome after switching from ticagrelor to clopidogrel in a real-life scenario: data from a prospective registry.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Angiography; Cause of Death; Clopidogrel; Comorbidity; Drug Substitution; Female; Health Care Surveys; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Registries; Risk Factors; Ticagrelor; Ticlopidine | 2016 |
P2Y12 Receptor Modulates Sepsis-Induced Inflammation.
Topics: Acute Lung Injury; Animals; Blood Platelets; Clopidogrel; Cytokines; Genetic Predisposition to Disease; Leukocytes; Lung; Male; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; P-Selectin; Phenotype; Platelet Activation; Platelet Aggregation Inhibitors; Pneumonia; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Sepsis; Signal Transduction; Ticlopidine | 2016 |
Proton pump inhibitors and other disease-based factors in the recurrence of adverse cardiovascular events following percutaneous coronary angiography: A long-term cohort.
Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Drug Combinations; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Retrospective Studies; Risk; Ticlopidine; Time Factors | 2016 |
High on-treatment platelet reactivity and outcomes after percutaneous endovascular procedures in patients with peripheral artery disease.
Topics: Aged; Aspirin; Blood Platelets; Chi-Square Distribution; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Endovascular Procedures; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Peripheral Arterial Disease; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Recurrence; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Platelets are dispensable for antibody-mediated transfusion-related acute lung injury in the mouse.
Topics: Animals; Antibodies, Monoclonal; Aspirin; Blood Platelets; Blood Transfusion; Clopidogrel; Diphtheria Toxin; Edema; Hemorrhage; Histocompatibility Antigens Class I; Lung; Male; Megakaryocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neutrophils; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Respiratory Distress Syndrome; Signal Transduction; Thrombocytopenia; Ticlopidine; Transfusion-Related Acute Lung Injury | 2016 |
Branch Retinal Artery Occlusion Imaged With Spectral-Domain Optical Coherence Tomographic Angiography.
Topics: Acute Disease; Aged, 80 and over; Blindness; Clopidogrel; Follow-Up Studies; Humans; Male; Retinal Artery Occlusion; Risk Assessment; Severity of Illness Index; Ticlopidine; Tomography, Optical Coherence | 2016 |
Coronary Thrombosis and Major Bleeding After PCI With Drug-Eluting Stents: Risk Scores From PARIS.
Topics: Acute Coronary Syndrome; Age Factors; Aged; Anemia; Aspirin; Body Mass Index; Clopidogrel; Cohort Studies; Coronary Thrombosis; Diabetes Mellitus; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Medication Adherence; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Registries; Renal Insufficiency; Risk Assessment; Smoking; Ticlopidine; United States | 2016 |
One-year incidence and clinical impact of bleeding events in patients treated with prasugrel or clopidogrel after ST-segment elevation myocardial infarction.
Topics: Aged; Clopidogrel; Female; Follow-Up Studies; France; Hemorrhage; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prognosis; Prospective Studies; Risk Factors; ST Elevation Myocardial Infarction; Ticlopidine; Time Factors | 2016 |
The contemporary management of intracranial atherosclerotic disease.
Topics: Angioplasty; Aspirin; Clopidogrel; Fibrinolytic Agents; Humans; Intracranial Arteriosclerosis; Stroke; Ticlopidine | 2016 |
Parathyroid Hormone Levels and High-Residual Platelet Reactivity in Patients Receiving Dual Antiplatelet Therapy With Acetylsalicylic Acid and Clopidogrel or Ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Aged; Aspirin; Biomarkers; Clopidogrel; Coronary Artery Disease; Databases, Factual; Drug Resistance; Drug Therapy, Combination; Female; Homeodomain Proteins; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticagrelor; Ticlopidine; Time Factors; Transcription Factors; Treatment Outcome; Up-Regulation | 2016 |
Clopidogrel-induced Thrombotic Microangiopathy in a Patient with Hypocomplementemia.
Topics: Acute Kidney Injury; Adrenal Cortex Hormones; Aged; Anemia, Hemolytic; Cerebral Infarction; Clopidogrel; Humans; Male; Plasma Exchange; Platelet Aggregation Inhibitors; Thrombotic Microangiopathies; Ticlopidine | 2016 |
Timing of Coronary Bypass Surgery in Patients Receiving Clopidogrel: The Role of VerifyNow.
Topics: Clopidogrel; Coronary Artery Bypass; Guidelines as Topic; Humans; Platelet Aggregation Inhibitors; Point-of-Care Systems; Postoperative Hemorrhage; Preoperative Care; Risk Factors; Ticlopidine; Treatment Outcome | 2016 |
Pharmacogenetics of Clopidogrel: An Unresolved Issue.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Electrocardiography; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Pharmacogenetics; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2016 |
Advanced age and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor: reply.
Topics: Adenosine; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2016 |
Impact of an integrated treatment algorithm based on platelet function testing and clinical risk assessment: results of the TRIAGE Patients Undergoing Percutaneous Coronary Interventions To Improve Clinical Outcomes Through Optimal Platelet Inhibition stu
Topics: Aged; Algorithms; Clinical Decision-Making; Clopidogrel; Hemorrhage; Humans; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Risk Assessment; Thienopyridines; Ticlopidine; Treatment Outcome | 2016 |
In Vitro Effects of Pantoprazole on Platelet Aggregation in Blood Samples From Clopidogrel and Aspirin-treated Patients.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aspirin; Clopidogrel; Cohort Studies; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2016 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) polymorphism and clopidogrel concentration in acute coronary syndrome: molecular change can explain the observed therapeutic concentration.
Topics: Acute Coronary Syndrome; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Humans; Polymorphism, Genetic; Ticlopidine | 2016 |
[ST-segment elevation myocardial infarction in the eastern urban China: from 2001 to 2011].
Topics: Aged; Aspirin; China; Clopidogrel; Female; Hospitalization; Hospitals; Humans; Logistic Models; Male; Middle Aged; Percutaneous Coronary Intervention; Registries; Retrospective Studies; Risk Factors; ST Elevation Myocardial Infarction; Ticlopidine | 2016 |
[Relationship between ATP-binding cassette subfamily B member 1 and cytochrome P450 2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Alleles; Angina Pectoris; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Genotype; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Tandem Mass Spectrometry; Ticlopidine | 2016 |
[Minor head injuries under antiocoagulation-antiplatelet drugs distributed like lozenges].
Topics: Anticoagulants; Aspirin; Cerebral Hemorrhage, Traumatic; Clopidogrel; Craniocerebral Trauma; Dosage Forms; Guideline Adherence; Humans; Patient Admission; Phenprocoumon; Platelet Aggregation Inhibitors; Ticlopidine; Tomography, X-Ray Computed | 2016 |
[After the first stroke, acetylsalicylic acid is no longer enough].
Topics: Aged; Aspirin; Clopidogrel; Drug Substitution; Drug Therapy, Combination; Humans; Recurrence; Stroke; Ticlopidine | 2016 |
Comparison of short-term clinical outcomes between ticagrelor versus clopidogrel in patients with acute myocardial infarction undergoing successful revascularization; from Korea Acute Myocardial Infarction Registry-National Institute of Health.
Topics: Adenosine; Clopidogrel; Female; Hemorrhage; Hospitalization; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Propensity Score; Registries; Republic of Korea; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Continued vorapaxar versus withdrawed clopidogrel both on top of low dose aspirin in patients undergoing heart surgery: A call for randomized trial.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Female; Humans; Lactones; Male; Myocardial Infarction; Postoperative Hemorrhage; Pyridines; Survival Analysis; Ticlopidine; Treatment Outcome | 2016 |
Associations of CYP3A4, NR1I2, CYP2C19 and P2RY12 polymorphisms with clopidogrel resistance in Chinese patients with ischemic stroke.
Topics: Aged; Asian People; Case-Control Studies; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Resistance; Female; Genetic Association Studies; Genotype; Humans; Hypertension; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Pregnane X Receptor; Protective Factors; Receptors, Purinergic P2Y12; Receptors, Steroid; Risk Factors; Stroke; Ticlopidine | 2016 |
Serum uric acid levels during dual antiplatelet therapy with ticagrelor or clopidogrel: Results from a single-centre study.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Biomarkers; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; Up-Regulation; Uric Acid | 2016 |
Association of CYP2C19 Polymorphisms with the Clinical Efficacy of Clopidogrel Therapy in Patients Undergoing Carotid Artery Stenting in Asia.
Topics: Aged; Alleles; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prognosis; Stents; Stroke; Ticlopidine; Treatment Outcome | 2016 |
Antiplatelet and Anticoagulant Medications Significantly Increase the Risk of Postoperative Hematoma: Review of over 4500 Thyroid and Parathyroid Procedures.
Topics: Anticoagulants; Aspirin; Clopidogrel; Female; Hematoma; Humans; Male; Middle Aged; Parathyroidectomy; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Risk Factors; Thyroidectomy; Ticlopidine | 2016 |
Mortality in primary angioplasty patients starting antiplatelet therapy with prehospital prasugrel or clopidogrel: a 1-year follow-up from the European MULTIPRAC Registry.
Topics: Administration, Oral; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Administration Schedule; Emergency Medical Services; Europe; Female; Hospital Mortality; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Registries; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Extended use of clopidogrel and aspirin after ischemic stroke.
Topics: Aspirin; Clopidogrel; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Post-Exposure Prophylaxis; Stroke; Ticlopidine | 2016 |
Extended use of clopidogrel and aspirin after ischemic stroke.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Drug Administration Schedule; Humans; Platelet Aggregation Inhibitors; Post-Exposure Prophylaxis; Stroke; Ticlopidine | 2016 |
Hospital Variation in Premature Clopidogrel Discontinuation After Drug-Eluting Stent Placement in the Veterans Affairs (VA) Healthcare System.
Topics: Aftercare; Aged; Cardiology; Cause of Death; Clopidogrel; Coronary Artery Disease; Deprescriptions; Drug-Eluting Stents; Female; Hospitals; Humans; Male; Middle Aged; Mortality; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proportional Hazards Models; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors; United States; United States Department of Veterans Affairs | 2016 |
Sex-related differences in outcomes among men and women under 55 years of age with acute coronary syndrome undergoing percutaneous coronary intervention: Results from the PROMETHEUS study.
Topics: Acute Coronary Syndrome; Age Factors; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Prasugrel Hydrochloride; Prognosis; Retrospective Studies; Risk Assessment; Sex Distribution; Sex Factors; Survival Rate; Ticlopidine; Treatment Outcome; United States | 2017 |
Cost-effectiveness analysis of personalized antiplatelet therapy in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Decision Support Techniques; Drug Costs; Humans; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenomic Testing; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Quality-Adjusted Life Years; Ticagrelor; Ticlopidine | 2016 |
Initiation and persistence with dual antiplatelet therapy after acute myocardial infarction: a Danish nationwide population-based cohort study.
Topics: Adenosine; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cohort Studies; Denmark; Drug Prescriptions; Drug Therapy, Combination; Female; Humans; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; Ticagrelor; Ticlopidine | 2016 |
Coronary artery bypass grafting-related bleeding complications in patients treated with dual antiplatelet treatment.
Topics: Adenosine; Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Hemorrhage; Preoperative Care; Retrospective Studies; Ticagrelor; Ticlopidine | 2016 |
Complication of Stenting in Intracranial Arterial Stenosis.
Topics: Age Factors; Aged; Angioplasty; Aspirin; China; Clopidogrel; Computed Tomography Angiography; Constriction, Pathologic; Female; Follow-Up Studies; Humans; Intracranial Arteriosclerosis; Kaplan-Meier Estimate; Male; Middle Aged; Perioperative Period; Postoperative Complications; Proportional Hazards Models; Recurrence; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2016 |
Platelet reactivity in patients receiving a maintenance dose of P2Y12-ADP receptor antagonists undergoing elective percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pilot Projects; Platelet Activation; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
[Safety of implantation permanent pacemaker at different times in patients with dual antiplatelet therapy].
Topics: Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Hematoma; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2016 |
Utility of the HAS-BLED Score in Risk Stratifying Patients on Dual Antiplatelet Therapy Post 12 Months After Drug-Eluting Stent Placement.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Drug Administration Schedule; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Georgia; Hemorrhage; Humans; Incidence; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Period; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Risk Assessment; Ticlopidine; Time Factors | 2017 |
Endovascular Treatment of 147 Cases of Cavernous Carotid Aneurysms: A Single-Center Experience.
Topics: Adult; Aspirin; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Female; Follow-Up Studies; Heart Aneurysm; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2016 |
Shaving and clopidogrel in elderly: shouldwe be worried?
Topics: Aged, 80 and over; Anticoagulants; Clopidogrel; Drug Therapy, Combination; Ecchymosis; Enoxaparin; Hair Removal; Humans; Male; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Switching from clopidogrel to prasugrel or ticagrelor: tips and tricks.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2016 |
Aspirin, but not clopidogrel, ameliorates vasomotor symptoms due to essential thrombocythemia: A case report.
Topics: Aspirin; Clopidogrel; Drug Resistance; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombocythemia, Essential; Ticlopidine; Vasomotor System | 2016 |
Clopidogrel loading dose in the management of ST elevation myocardial infarction: Still a debate!
Topics: Clopidogrel; Guideline Adherence; Humans; Platelet Aggregation Inhibitors; ST Elevation Myocardial Infarction; Ticlopidine | 2016 |
Exome sequencing of extreme clopidogrel response phenotypes identifies B4GALT2 as a determinant of on-treatment platelet reactivity.
Topics: Adult; Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Exome; Female; Galactosyltransferases; Genotype; Humans; Male; Middle Aged; Phenotype; Pilot Projects; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Bleeding complications of triple antithrombotic therapy after percutaneous coronary interventions.
Topics: Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Coronary Artery Disease; Drug Administration Schedule; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Ohio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2017 |
Effect of a combination of antiplatelet and antithrombotic pretreatment on myocardial perfusion in patients with an acute ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Biomarkers; Clopidogrel; Coronary Angiography; Coronary Circulation; Drug Therapy, Combination; Electrocardiography; Female; Fibrinolytic Agents; Heparin; Humans; Male; Middle Aged; Patient Transfer; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; ST Elevation Myocardial Infarction; Ticlopidine; Time Factors; Time-to-Treatment; Treatment Outcome; Troponin T | 2016 |
Interaction of CYP2C19, P2Y12, and GPIIIa Variants Associates With Efficacy of Clopidogrel and Adverse Events on Patients With Ischemic Stroke.
Topics: Aged; Aged, 80 and over; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Variation; Humans; Integrin beta3; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Recurrence; Stroke; Ticlopidine | 2017 |
Prehospital Clopidogrel Administration in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary PCI: Real-Life Experience From the Multicenter NRDES Registry.
Topics: Aged; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Registries; ST Elevation Myocardial Infarction; Ticlopidine | 2016 |
High On-Treatment Platelet Reactivity in Peripheral Arterial Disease: A Pilot Study to Find the Optimal Test and Cut Off Values.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Peripheral Arterial Disease; Pilot Projects; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2016 |
Paraoxonases-1, -2 and -3: What are their functions?
Topics: Animals; Aryldialkylphosphatase; Astrocytes; Carotid Artery Diseases; Cells, Cultured; Clopidogrel; Endoplasmic Reticulum; Female; Genotype; Homocysteine; Humans; Inflammation; Lipid Metabolism; Lipoproteins, HDL; Male; Mice; Mice, Knockout; Mitochondria; Neurons; Organophosphorus Compounds; Oxidative Stress; Platelet Aggregation Inhibitors; Quorum Sensing; Ticlopidine | 2016 |
Effects of Sarpogrelate Combined with Aspirin in Patients Undergoing Carotid Endarterectomy in China: A Single-Center Retrospective Study.
Topics: Aged; Aspirin; Blood Loss, Surgical; Carotid Stenosis; China; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Hematoma; Humans; Male; Middle Aged; Operative Time; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Succinates; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Hydrolysis; Male; Metabolic Networks and Pathways; Models, Molecular; Molecular Conformation; Phenylacetates; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Thiophenes; Ticlopidine | 2016 |
Deciphering glycomics and neuroproteomic alterations in experimental traumatic brain injury: Comparative analysis of aspirin and clopidogrel treatment.
Topics: Animals; Aspirin; Brain Injuries, Traumatic; Cerebellar Cortex; Clopidogrel; Gene Expression Regulation; Glycomics; Glycosylation; Humans; Male; Platelet Aggregation Inhibitors; Protein Processing, Post-Translational; Proteomics; Rats; Rats, Sprague-Dawley; Ticlopidine | 2016 |
[THE FIRST RESULTS OF THE PREVALENCE OF CYP2C19 GENEPOLYMORPHISM IN PATIENTS WITH ACUTE CORONARY SYNDROME IN THE AKTYUBINSK POPULATION].
Topics: Acute Coronary Syndrome; Adult; Aged; Asian People; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Association Studies; Humans; Kazakhstan; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; White People | 2016 |
[The incidence, clinical characteristics and risk factors of upper gastrointestinal bleeding in patients taking dual antiplatelet therapy after percutaneous coronary intervention in south China].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; China; Clopidogrel; Coronary Artery Disease; Female; Gastrointestinal Hemorrhage; Humans; Incidence; Male; Peptic Ulcer; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Upper Gastrointestinal Tract | 2016 |
Antiplatelet drug resistance is associated with early neurological deterioration in acute minor ischemic stroke in the Chinese population.
Topics: Aged; Aged, 80 and over; Asian People; Aspirin; Brain Ischemia; Clopidogrel; Female; Humans; Male; Middle Aged; Nervous System Diseases; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2016 |
A rabbit model of cerebral microembolic signals for translational research: preclinical validation for aspirin and clopidogrel.
Topics: Animals; Aspirin; Carotid Artery Thrombosis; Chlorides; Clopidogrel; Disease Models, Animal; Drug Evaluation, Preclinical; Ferric Compounds; Fibrinolytic Agents; Intracranial Embolism; Male; Middle Cerebral Artery; Platelet Aggregation; Rabbits; Stroke; Ticlopidine; Translational Research, Biomedical; Ultrasonography; Ultrasonography, Doppler | 2016 |
A State Transition Model for Health Outcomes Associated with Vorapaxar Treatment as an Add-on to Standard Care Antiplatelet Therapy in the Prevention of Thrombotic Events for Patients with a Recent Myocardial Infarction.
Topics: Aspirin; Cardiovascular System; Clopidogrel; Hemorrhage; Humans; Lactones; Myocardial Infarction; Platelet Aggregation Inhibitors; Pyridines; Secondary Prevention; Stroke; Thrombosis; Ticlopidine; Treatment Outcome | 2016 |
The first six-month clinical outcomes and risk factors associated with high on-treatment platelet reactivity of clopidogrel in patients undergoing coronary interventions.
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Ticlopidine; Treatment Outcome; Turkey | 2016 |
Impaired P2Y12 inhibition by clopidogrel in kidney transplant recipients: results from a cohort study.
Topics: Aged; Clopidogrel; Cohort Studies; Female; Humans; Kidney Transplantation; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Registries; Renal Insufficiency, Chronic; Retrospective Studies; Ticlopidine | 2016 |
High platelet reactivity on aspirin in patients with acute ST elevation myocardial infarction.
Topics: Acute Disease; Adenosine; Aspirin; Blood Platelets; Brain Ischemia; Cardiovascular Diseases; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Survival Analysis; Ticagrelor; Ticlopidine | 2016 |
Effect of Fibrinogen on Platelet Reactivity Measured by the VerifyNow P2Y12 Assay.
Topics: Atherosclerosis; Blood Platelets; Clopidogrel; Fibrinogen; Humans; Immobilized Proteins; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Function Tests; Receptors, Purinergic P2Y12; Regression Analysis; Ticlopidine | 2016 |
The Paradox of Smoking and Clopidogrel Effect - Dr Jekyll or Mr Hyde?
Topics: Clopidogrel; Humans; Smoking; Ticlopidine | 2016 |
Incidence and Clinical Features of Early Stent Thrombosis in the Era of New P2y12 Inhibitors (PLATIS-2).
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Clopidogrel; Early Diagnosis; Female; Humans; Israel; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; Stents; Stroke; Survival Analysis; Thrombosis; Ticagrelor; Ticlopidine | 2016 |
[ANMCO/SIC/SICI-GISE/SICCH Consensus document: Clinical approach to pharmacological pretreatment for patients undergoing myocardial revascularization].
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clopidogrel; Drug Therapy, Combination; Fondaparinux; Heparin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Italy; Myocardial Revascularization; Platelet Aggregation Inhibitors; Polysaccharides; Preoperative Care; Ticlopidine; Treatment Outcome | 2016 |
Etravirine as a culprit of recurrent drug-eluting in-stent restenosis in an HIV patient.
Topics: Clopidogrel; Coronary Restenosis; Drug Interactions; Drug-Eluting Stents; Female; HIV Infections; Humans; Middle Aged; Nitriles; Pyridazines; Pyrimidines; Ticlopidine | 2016 |
[Retrospective cohort study for the impact on readmission of patients with ischemic stroke after treatment of aspirin plus clopidogrel or aspirin mono-therapy].
Topics: Aspirin; Beijing; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Patient Readmission; Platelet Aggregation Inhibitors; Proportional Hazards Models; Recurrence; Retrospective Studies; Secondary Prevention; Stroke; Ticlopidine | 2016 |
Relationship between diabetes, platelet reactivity, and the SYNTAX score to one-year clinical outcome in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Blood Platelets; Clopidogrel; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2016 |
Endovascular Treatment of Nutcracker Syndrome.
Topics: Adult; Alloys; Clopidogrel; Endovascular Procedures; Female; Humans; Magnetic Resonance Angiography; Phlebography; Platelet Aggregation Inhibitors; Prosthesis Design; Renal Circulation; Renal Nutcracker Syndrome; Renal Veins; Stents; Ticlopidine; Treatment Outcome; Ultrasonography, Doppler, Duplex; Vascular Patency | 2016 |
CYP2C19 polymorphisms in acute coronary syndrome patients undergoing clopidogrel therapy in Zhengzhou population.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Genetic Association Studies; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Ticagrelor; Ticlopidine | 2016 |
Measurement of residual platelet thrombogenicity under arterial shear conditions in cerebrovascular disease patients receiving antiplatelet therapy.
Topics: Adult; Aged; Arteries; Aspirin; Blood Coagulation Tests; Blood Platelets; Carotid Arteries; Cell Adhesion Molecules; Cerebrovascular Circulation; Cerebrovascular Disorders; Clopidogrel; Constriction, Pathologic; Cross-Sectional Studies; Female; Humans; Male; Microfilament Proteins; Middle Aged; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Shear Strength; Thrombosis; Ticlopidine; Vasodilator Agents; Young Adult | 2016 |
High-Sensitive C-Reactive Protein Predicts Recurrent Stroke and Poor Functional Outcome: Subanalysis of the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events Trial.
Topics: Aged; Aspirin; C-Reactive Protein; Clopidogrel; Drug Therapy, Combination; Female; Humans; Incidence; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Stroke; Ticlopidine | 2016 |
Dynamic platelet adhesion in patients with an acute coronary syndrome: The effect of antiplatelet therapy.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Biomarkers; Blood Platelets; Case-Control Studies; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Efficacy and safety of ticagrelor versus clopidogrel in acute coronary syndrome in Taiwan: A multicenter retrospective pilot study.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Ticagrelor; Ticlopidine | 2016 |
Pharmacologic provocation combined with endoscopy in refractory cases of GI bleeding.
Topics: Aged; Aged, 80 and over; Anticoagulants; Balloon Enteroscopy; Clopidogrel; Female; Gastrointestinal Hemorrhage; Heparin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Rivaroxaban; Ticlopidine; Vascular Malformations | 2017 |
Effect of genetic and coexisting polymorphisms on platelet response to clopidogrel in Chinese Han patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Alleles; Aryldialkylphosphatase; Asian People; ATP Binding Cassette Transporter, Subfamily B; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Female; Gene Expression; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prospective Studies; Receptors, Purinergic P2Y12; Ticlopidine | 2016 |
CYP2C19 loss-of-function alleles are not associated with clinical outcome of clopidogrel therapy in patients treated with newer-generation drug-eluting stents.
Topics: Acute Coronary Syndrome; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2016 |
The Impact of Timing of Ischemic and Hemorrhagic Events on Mortality After Percutaneous Coronary Intervention: The ADAPT-DES Study.
Topics: Aged; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Germany; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Registries; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; United States | 2016 |
CYP2C19 but not CYP2B6, CYP3A4, CYP3A5, ABCB1, PON1 or P2Y12 genetic polymorphism impacts antiplatelet response after clopidogrel in Koreans.
Topics: ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 Enzyme System; Female; Humans; Korea; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prospective Studies; Ticlopidine | 2017 |
Optimizing prevention and guideline-concordant care in Montenegro.
Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiovascular Agents; Clopidogrel; Evidence-Based Medicine; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Medication Adherence; Middle Aged; Montenegro; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prospective Studies; Ticlopidine | 2016 |
Safety and effectiveness of the new P2Y12r inhibitor agents vs clopidogrel in ACS patients according to the geographic area: East Asia vs Europe.
Topics: Acute Coronary Syndrome; Aged; Asia, Eastern; Clopidogrel; Europe; Female; Follow-Up Studies; Hemorrhage; Humans; Internationality; Male; Middle Aged; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Registries; Retrospective Studies; Ticlopidine; Treatment Outcome | 2016 |
Ticagrelor for left ventricular assist device thrombosis: A new therapeutic option to be evaluated with caution.
Topics: Adenosine; Aged; Aspirin; Blood Coagulation; Cardiomyopathies; Clopidogrel; Drug Substitution; Drug Therapy, Combination; Fibrinolytic Agents; Heart-Assist Devices; Humans; Male; Medication Therapy Management; Postoperative Complications; Risk Adjustment; Thrombosis; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Evaluation of Clopidogrel Conjugation Metabolism: PK Studies in Man and Mice of Clopidogrel Acyl Glucuronide.
Topics: Adolescent; Adult; Animals; Clopidogrel; Female; Glucuronides; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult | 2016 |
Treating Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Age Factors; Aged; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2015 |
Clopidogrel High On-Treatment Platelet Reactivity in Patients with Carotid Artery Stenosis Undergoing Endarterectomy. A Pilot Study.
Topics: Aged; Carotid Stenosis; Chi-Square Distribution; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Endarterectomy, Carotid; Female; Genotype; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pharmacogenetics; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Efficacy of a two-test protocol for achieving a therapeutic response to clopidogrel prior to elective endovascular intracranial aneurysm treatment and an 'induced' postoperative hyper-response.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Cohort Studies; Elective Surgical Procedures; Endovascular Procedures; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Prospective Studies; Retrospective Studies; Ticlopidine; Treatment Outcome | 2017 |
Outcomes in patients treated with ticagrelor or clopidogrel after acute myocardial infarction: experiences from SWEDEHEART registry.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Ticagrelor; Ticlopidine; Treatment Outcome | 2016 |
Comparing Inverse Probability of Treatment Weighting and Instrumental Variable Methods for the Evaluation of Adenosine Diphosphate Receptor Inhibitors After Percutaneous Coronary Intervention.
Topics: Adenosine Diphosphate; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2016 |
Preoperative antiplatelet use does not increase incidence of bleeding after major operations.
Topics: Adult; Aged; Blood Loss, Surgical; Clopidogrel; Databases, Factual; Elective Surgical Procedures; Female; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Period; Reference Values; Retrospective Studies; Risk Assessment; Surgical Procedures, Operative; Ticlopidine | 2016 |
Relationship of paraoxonase-1 Q192R genotypes and in-stent restenosis and re-stenting in Chinese patients after coronary stenting.
Topics: Adult; Aged; Alleles; Aryldialkylphosphatase; ATP Binding Cassette Transporter, Subfamily B; Body Mass Index; China; Clopidogrel; Cohort Studies; Coronary Restenosis; Coronary Vessels; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prevalence; Regression Analysis; Risk Factors; Stents; Ticlopidine; Treatment Outcome | 2016 |
Clarification of the Mechanism of Clopidogrel-Mediated Drug-Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information.
Topics: Area Under Curve; Clopidogrel; Cytochrome P-450 CYP2C8; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Male; Platelet Aggregation Inhibitors; Quinolines; Rifampin; Ticlopidine; Trimethoprim | 2016 |
The Effect of Antiplatelet Agents on Bleeding-Related Complications After Ureteroscopy.
Topics: Adenosine; Adult; Aged; Anticoagulants; Aspirin; Blood Platelets; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Risk; Ticagrelor; Ticlopidine; Ureteroscopy | 2016 |
Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model.
Topics: Aneurysm; Animals; Aspirin; Carotid Artery Diseases; Carotid Artery, External; Cell Movement; Clopidogrel; Disease Models, Animal; Drug Therapy, Combination; Embolization, Therapeutic; Equipment Design; Macrophages; Male; Platelet Aggregation Inhibitors; Platinum; Rats, Sprague-Dawley; Ticlopidine; Time Factors; Wound Healing | 2016 |
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.
Topics: 1-Naphthylisothiocyanate; Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Clopidogrel; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Activation; Purinergic P2Y Receptor Antagonists; Receptors, Proteinase-Activated; Serotonin; Ticlopidine; Xenobiotics | 2016 |
EBUS-TBNA and EUS-FNA: Risk Assessment for Patients Receiving Clopidogrel.
Topics: Age Factors; Aged; Biopsy, Fine-Needle; Clopidogrel; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Esophagus; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Ticlopidine; Ultrasonography | 2016 |
Effect of Ginkgo Biloba Extract on the Pharmacokinetics and Metabolism of Clopidogrel in Rats.
Topics: Animals; Clopidogrel; Ginkgo biloba; Herb-Drug Interactions; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Ticlopidine | 2016 |
Genotype Frequencies of CYP2C19, P2Y12 and GPIIIa Polymorphisms in Coronary Heart Disease Patients of Han Ethnicity, and Their Impact on Clopidogrel Responsiveness.
Topics: Aged; Aged, 80 and over; Asian People; China; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Integrin beta3; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Receptors, Purinergic P2Y12; Ticlopidine | 2016 |
Locked Away: Percutaneous Closure of a Malignant Left Atrial Appendage to Constrain an Unresolvable Thrombus.
Topics: Aged; Aspirin; Atrial Appendage; Atrial Fibrillation; Catheter Ablation; Clopidogrel; Combined Modality Therapy; Coronary Angiography; Echocardiography, Transesophageal; Factor Xa Inhibitors; Humans; Male; Platelet Aggregation Inhibitors; Rivaroxaban; Septal Occluder Device; Thrombosis; Ticlopidine; Vitamin K | 2016 |
The Impact of Type 2 Diabetes on the Efficacy of ADP Receptor Blockers in Patients with Acute ST Elevation Myocardial Infarction: A Pilot Prospective Study.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Case-Control Studies; Clopidogrel; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Flow Cytometry; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Ticlopidine | 2016 |
Successful multivessel percutaneous coronary intervention for acute coronary syndrome in a HIV-positive severe haemophiliac.
Topics: Acute Coronary Syndrome; Clopidogrel; Hematuria; Hemophilia A; Hemorrhage; HIV Infections; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Risk Factors; Severity of Illness Index; Ticlopidine | 2016 |
Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis.
Topics: Animals; Arteries; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Mice; Mice, Inbred C57BL; Platelet Aggregation; Pyridines; Rabbits; Thrombosis; Ticlopidine | 2016 |
Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo via an adenosine-dependent mechanism.
Topics: Adenosine; Animals; Blood Platelets; Bone Regeneration; Clopidogrel; Dipyridamole; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Osteogenesis; Platelet Activation; Receptor, Adenosine A2A; Ticagrelor; Ticlopidine | 2016 |
Antithrombotic Medication Use and Misuse Among Patients with Intracranial Hemorrhage: A 16-Year, Lebanese, Single-Center Experience.
Topics: Acenocoumarol; Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Cerebral Hemorrhage; Clopidogrel; Coronary Artery Disease; Enoxaparin; Female; Fibrinolytic Agents; Humans; Inappropriate Prescribing; Intracranial Hemorrhages; Lebanon; Male; Middle Aged; Platelet Aggregation Inhibitors; Prescription Drug Misuse; Retrospective Studies; Risk Factors; Stroke; Ticlopidine; Warfarin; Young Adult | 2016 |
Predictors for Side Branch Failure During Provisional Strategy of Coronary Intervention for Bifurcation Lesions (from the Korean Bifurcation Registry).
Topics: Aged; Calcinosis; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Coronary Stenosis; Coronary Vessels; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Multivariate Analysis; Organ Size; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Registries; Republic of Korea; Risk Factors; Ticlopidine; Treatment Failure | 2016 |
Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation.
Topics: Animals; Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Male; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
[CHARISMA study].
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Embolism; Female; Humans; Male; Middle Aged; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Changes in response to clopidogrel therapy in patients after percutaneous coronary interventions as assessed by different platelet function tests.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2016 |
Microparticles and blood cells induce procoagulant activity via phosphatidylserine exposure in NSTEMI patients following stent implantation.
Topics: Aged; Aspirin; Blood Cells; Blood Coagulation; Cell-Derived Microparticles; Clopidogrel; Female; Humans; Male; Middle Aged; Non-ST Elevated Myocardial Infarction; Percutaneous Coronary Intervention; Phosphatidylserines; Platelet Aggregation Inhibitors; Statistics as Topic; Stents; Thrombophilia; Ticlopidine | 2016 |
Clopidogrel pharmacogenetics: from evidence to implementation.
Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2016 |
Cigarette Smoking Does Not Enhance Clopidogrel Responsiveness After Adjusting VerifyNow P2Y12 Reaction Unit for the Influence of Hemoglobin Level.
Topics: Aged; Biomarkers; Blood Platelets; Clopidogrel; Coronary Disease; Drug-Eluting Stents; Female; Hemoglobins; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Reproducibility of Results; Retrospective Studies; Risk Factors; Smoking; Ticlopidine; Treatment Outcome | 2016 |
Smoking and Clopidogrel Response Revisited: Hemoglobin Levels Explaining the Smoker's Paradox.
Topics: Clopidogrel; Hemoglobins; Smokers; Smoking; Ticlopidine | 2016 |
Vitamin D levels and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor.
Topics: Adenosine; Adenosine Diphosphate; Aged; Aged, 80 and over; Biomarkers; Blood Platelets; Clopidogrel; Comorbidity; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Odds Ratio; Platelet Activation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Vitamin D | 2016 |
Antiplatelet Therapy is Associated with a Better Prognosis for Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma after Liver Resection.
Topics: Adult; Aged; Aspirin; Carcinoma, Hepatocellular; Clopidogrel; Disease-Free Survival; Female; Gastrointestinal Hemorrhage; Hepatectomy; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Factors; Survival Rate; Taiwan; Ticlopidine | 2016 |
Activated platelets inhibit hepatocellular carcinoma cell differentiation and promote tumor progression via platelet-tumor cell binding.
Topics: Adenosine Diphosphate; Aged; Animals; Blood Platelets; Carcinogenesis; Carcinoma, Hepatocellular; Cell Differentiation; Clopidogrel; Female; Hep G2 Cells; Humans; Intercellular Junctions; Liver Neoplasms; Male; Mice; Mice, SCID; Middle Aged; P-Selectin; Platelet Activation; Protein Binding; RNA, Small Interfering; Ticlopidine; Transcription Factor 4; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2016 |
Integrated analysis of miRNA and mRNA gene expression microarrays: Influence on platelet reactivity, clopidogrel response and drug-induced toxicity.
Topics: Animals; Blood Platelets; Clopidogrel; Databases, Nucleic Acid; Gene Expression Profiling; Gene Expression Regulation; Humans; MicroRNAs; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Ticlopidine | 2016 |
CASE 11-2016 Perioperative Coronary Thrombosis in a Patient With Multiple Second-Generation Drug-Eluting Stents: Is It Time for a Paradigm Shift?
Topics: Analgesics, Opioid; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopidogrel; Coronary Thrombosis; Drug-Eluting Stents; Female; Humans; Metoprolol; Middle Aged; Morphine; Myocardial Infarction; Nitroglycerin; Ovarian Neoplasms; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Retreatment; Ticlopidine; Treatment Outcome; Vasodilator Agents | 2016 |
Concomitant Use of Proton Pump Inhibitors and Clopidogrel Is Not Associated with Adverse Outcomes after Ischemic Stroke in Chinese Population.
Topics: Aged; Aged, 80 and over; Brain Ischemia; China; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Disability Evaluation; Drug Interactions; Drug Resistance; Female; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Polypharmacy; Prospective Studies; Proton Pump Inhibitors; Recurrence; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Low-dose ticagrelor yields an antiplatelet efficacy similar to that of standard-dose ticagrelor in healthy subjects: an open-label randomized controlled trial.
Topics: Adenosine; Adult; China; Clopidogrel; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Humans; Male; Platelet Aggregation Inhibitors; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine; Young Adult | 2016 |
A retrospective study showing the extent of compliance with perioperative guidelines in patients with coronary stents with regard to double antiplatelet therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Case Management; Clopidogrel; Coronary Vessels; Female; Guideline Adherence; Humans; Male; Middle Aged; Perioperative Care; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Treatment Outcome | 2016 |
Clopidogrel use After Myocardial Revascularization: Prevalence, Predictors, and One-Year Survival Rate.
Topics: Aspirin; Cardiopulmonary Bypass; Clopidogrel; Coronary Artery Bypass; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Revascularization; North Carolina; Patient Discharge; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Postoperative Period; Prevalence; Prognosis; Survival Rate; Ticlopidine | 2016 |
Plasma miR-142 accounting for the missing heritability of CYP3A4/5 functionality is associated with pharmacokinetics of clopidogrel.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP3A; Female; Humans; Liver; Male; MicroRNAs; Middle Aged; Platelet Aggregation Inhibitors; RNA, Messenger; Ticlopidine | 2016 |
Identifying clinically relevant sources of variability: The clopidogrel challenge.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Body Mass Index; Clopidogrel; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Interactions; Female; Gastrointestinal Absorption; Half-Life; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Obesity; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Socioeconomic Factors; Ticlopidine | 2017 |
Associations of P2Y12R gene polymorphisms with susceptibility to coronary heart disease and clinical efficacy of antiplatelet treatment with clopidogrel.
Topics: Aged; Blood Platelets; Case-Control Studies; Chromatography, High Pressure Liquid; Clopidogrel; Coronary Disease; Drug Resistance; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; Humans; Male; Middle Aged; Pharmacogenetics; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y12; Risk Factors; Ticlopidine; Treatment Outcome | 2016 |
Risk of bleeding after hospitalization for a serious coronary event: a retrospective cohort study with nested case-control analyses.
Topics: Aged; Aged, 80 and over; Aspirin; Cerebral Hemorrhage; Clopidogrel; Confidence Intervals; Coronary Artery Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Hospitalization; Humans; Incidence; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Survival Rate; Ticlopidine; United Kingdom | 2016 |
Assessment of P2Y12 inhibitor usage and switching in acute coronary syndrome patients undergoing percutaneous coronary revascularization.
Topics: Acute Coronary Syndrome; Adenosine; Aftercare; Clopidogrel; Dose-Response Relationship, Drug; Drug Substitution; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Medication Therapy Management; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; Ticagrelor; Ticlopidine; Treatment Outcome; United States | 2016 |
Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Complications; Randomized Controlled Trials as Topic; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Trends in antithrombotic therapy for atrial fibrillation: Data from the Veterans Health Administration Health System.
Topics: Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Atrial Fibrillation; Clopidogrel; Dabigatran; Diabetes Mellitus; Female; Guideline Adherence; Heart Failure; Humans; Hypertension; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk; Risk Assessment; Stroke; Ticlopidine; United States; United States Department of Veterans Affairs; Warfarin | 2016 |
P2Y
Topics: Blood Platelets; Clopidogrel; Dose-Response Relationship, Drug; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Thromboembolism; Ticlopidine; Treatment Outcome | 2017 |
Determinants of agreement between proposed therapeutic windows of platelet function tests in vulnerable patients.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Risk Factors; ROC Curve; Ticlopidine; Treatment Outcome; Vulnerable Populations | 2017 |
Platelet Activation and Clopidogrel Effects on ADP-Induced Platelet Activation in Cats with or without the A31P Mutation in MYBPC3.
Topics: Adenosine Diphosphate; Animals; Carrier Proteins; Cat Diseases; Cats; Clopidogrel; Gene Expression Regulation; Genetic Predisposition to Disease; Genotype; Mutation; Platelet Activation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2016 |
Effect of Drugs Associated With Bleeding Tendency on the Complications and Outcomes of Transforaminal Epidural Steroid Injection.
Topics: Aged; alpha-Cyclodextrins; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Clopidogrel; Female; Follow-Up Studies; Hemorrhage; Humans; Injections, Epidural; Male; Middle Aged; Pain; Pain Measurement; Platelet Aggregation Inhibitors; Retrospective Studies; Steroids; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Stent-assisted coiling in ruptured cerebral aneurysms: multi-center experience in acute phase.
Topics: Acute Disease; Aneurysm, Ruptured; Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Neuroimaging; Platelet Aggregation Inhibitors; Radiography, Interventional; Retrospective Studies; Stents; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome | 2017 |
Influence of CYP2C19 genetic polymorphisms on clinical outcomes of intracranial aneurysms treated with stent-assisted coiling.
Topics: Adolescent; Adult; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Hemorrhage; Humans; Intracranial Aneurysm; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Stents; Ticlopidine; Treatment Outcome; Young Adult | 2017 |
Long term performance evaluation of small-diameter vascular grafts based on polyvinyl alcohol hydrogel and dextran and MSCs-based therapies using the ovine pre-clinical animal model.
Topics: Animals; Anticoagulants; Blood Vessel Prosthesis; Carotid Artery, Common; Clopidogrel; Dextrans; Heparin; Humans; Mesenchymal Stem Cell Transplantation; Models, Animal; Polyvinyl Alcohol; Sheep; Ticlopidine; Warfarin | 2016 |
Head to Head Comparison of Two Point-of-care Platelet Function Tests Used for Assessment of On-clopidogrel Platelet Reactivity in Chinese Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention.
Topics: Adenosine Diphosphate; Aged; Aspirin; Blood Platelets; China; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Receptors, Purinergic P2Y12; Thrombelastography; Ticlopidine | 2016 |
Clopidogrel pharmacogenetics: Beyond candidate genes and genome-wide association studies.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Exome; Genetic Variation; Genotype; Humans; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2017 |
Increased Platelet-leukocyte Aggregates Are Associated With Myocardial No-reflow in Patients With ST Elevation Myocardial Infarction.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Angiography; Coronary Circulation; Coronary Thrombosis; Electrocardiography; Female; Flow Cytometry; Humans; Leukocytes; Male; Middle Aged; Myocardial Infarction; No-Reflow Phenomenon; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Predictive Value of Tests; Retrospective Studies; Ticlopidine | 2016 |
The Diagnostic Utility of the Point-of-Care CYP2C19 Genotyping Assay in Patients with Acute Coronary Syndrome Dosing Clopidogrel: Comparison with Platelet Function Test and SNP Genotyping.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Female; Genotyping Techniques; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Polymorphism, Single Nucleotide; Ticlopidine | 2016 |
Impact of proton pump inhibitors and dual antiplatelet therapy cessation on outcomes following percutaneous coronary intervention: Results From the PARIS Registry.
Topics: Aged; Aspirin; Clopidogrel; Coronary Thrombosis; Drug Administration Schedule; Drug Antagonism; Drug Therapy, Combination; Europe; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proportional Hazards Models; Prospective Studies; Proton Pump Inhibitors; Registries; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome; United States | 2017 |
Rare case of bilateral traumatic internal carotid artery dissection.
Topics: Aspirin; Carotid Artery, Internal, Dissection; Clopidogrel; Headache; Humans; Infarction, Anterior Cerebral Artery; Male; Middle Aged; Neurologic Examination; Oculomotor Nerve Diseases; Platelet Aggregation Inhibitors; Ticlopidine; Tomography, X-Ray Computed; Treatment Outcome; Whole Body Imaging | 2016 |
Contribution of whole platelet aggregometry to the endovascular management of unruptured aneurysms: an institutional experience.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Disease Management; Endovascular Procedures; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; Stents; Ticlopidine | 2017 |
Effect of CYP2C19*2 and *3 on clinical outcome in ischemic stroke patients treated with clopidogrel.
Topics: Aged; Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Proportional Hazards Models; Retrospective Studies; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2016 |
Impact of Anticoagulant and Antiplatelet Drugs on Perioperative Outcomes of Robotic-assisted Partial Nephrectomy.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Kidney Neoplasms; Male; Middle Aged; Morbidity; Nephrectomy; Perioperative Care; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Robotic Surgical Procedures; Ticlopidine | 2017 |
Resuscitation experience in a patient with left ventricular assist device.
Topics: Anesthesia, General; Anticoagulants; Capnography; Cardiopulmonary Resuscitation; Clopidogrel; Defibrillators, Implantable; Epinephrine; Female; Heart Failure; Heart Ventricles; Heart-Assist Devices; Hemorrhage; Humans; Middle Aged; Monitoring, Intraoperative; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Warfarin | 2016 |
Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps.
Topics: Animals; Blood Platelets; Cell Line; Clopidogrel; Disease Models, Animal; DNA; Epithelial Cells; Extracellular Traps; Humans; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Mice, Inbred C57BL; Nephritis; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Factor 4; Reperfusion Injury; Signal Transduction; Ticlopidine; Time Factors | 2017 |
The moving target of clopidogrel response variability: new tricks of the old dog?
Topics: Clopidogrel; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Clopidogrel-Induced Auditory and Visual Hallucinations.
Topics: Aged, 80 and over; Auditory Perception; Clopidogrel; Female; Hallucinations; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Visual Perception | 2016 |
CYP2C19 genotyping combined with on-clopidogrel platelet reactivity in predicting major adverse cardiovascular events in Chinese patients with percutaneous coronary intervention.
Topics: Aged; Blood Platelets; China; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Proportional Hazards Models; Stents; Ticlopidine; Treatment Outcome | 2016 |
Left ventricular non-compaction cardiomyopathy: Incidental diagnosis after ST-elevation myocardial infarction.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Cardiomyopathy, Hypertrophic, Familial; Clopidogrel; Coronary Angiography; Drug-Eluting Stents; Echocardiography, Doppler, Color; Electrocardiography; Female; Hematologic Agents; Humans; Incidental Findings; ST Elevation Myocardial Infarction; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2016 |
Prasugrel versus clopidogrel in stent-assisted coil embolization of unruptured intracranial aneurysms.
Topics: Adult; Aged; Aspirin; Clopidogrel; Combined Modality Therapy; Drug Therapy, Combination; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Prasugrel Hydrochloride; Stents; Ticlopidine; Treatment Outcome | 2017 |
Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model.
Topics: Animals; Aspirin; Clopidogrel; Disease Models, Animal; Fibrinolytic Agents; Graft Survival; Heparin; Hirudins; Ischemia; Laser-Doppler Flowmetry; Male; Microcirculation; Pentoxifylline; Postoperative Complications; Rats; Rats, Wistar; Skin Diseases; Skin Transplantation; Surgical Flaps; Ticlopidine | 2016 |
Obesity, leptin, and thrombosis: Focus on clopidogrel resistance.
Topics: Animals; Biomedical Research; Clopidogrel; Drug Resistance; Humans; Leptin; Mice; Obesity; Thrombosis; Ticlopidine | 2016 |
Effect of obesity and serum leptin level on clopidogrel resistance.
Topics: Aged; Clopidogrel; Cohort Studies; Drug Resistance; Female; Humans; Leptin; Male; Middle Aged; Obesity; Ticlopidine | 2016 |
In-stent thrombosis when switching ticagrelor to clopidogrel after percutaneous coronary intervention.
Topics: Adenosine; Blood Platelets; Clopidogrel; Drug Administration Schedule; Drug Dosage Calculations; Drug Substitution; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Stents; Thrombosis; Ticagrelor; Ticlopidine | 2017 |
Impact of chronic kidney disease on platelet P2Y
Topics: Biomarkers; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Resistance; Humans; Microfilament Proteins; Phosphoproteins; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Renal Insufficiency, Chronic; Signal Transduction; Ticlopidine | 2017 |
Early Cessation of Adenosine Diphosphate Receptor Inhibitors Among Acute Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention: Insights From the TRANSLATE-ACS Study (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longi
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug Administration Schedule; Drug Costs; Female; Health Expenditures; Humans; Longitudinal Studies; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Prasugrel Hydrochloride; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Recurrence; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome; United States | 2016 |
Protective Effects of Ticagrelor on Myocardial Injury After Infarction.
Topics: Adenosine; Animals; Blood Platelets; Cardiotonic Agents; Clopidogrel; Cyclooxygenase 2; Myocardial Infarction; Platelet Aggregation Inhibitors; Random Allocation; Swine; Ticagrelor; Ticlopidine | 2016 |
Letter by Moris and Avgerinos Regarding Article, "Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke: Clopidogrel Plus Aspirin Versus Aspirin Alone".
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2016 |
Single versus double antiplatelet therapy in patients undergoing coronary artery bypass grafting with coronary endarterectomy: mid-term results and clinical implications.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Drug Therapy, Combination; Endarterectomy; Female; Follow-Up Studies; Hospital Mortality; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Treatment Outcome | 2017 |
Impact of Proton Pump Inhibitor Use on the Comparative Effectiveness and Safety of Prasugrel Versus Clopidogrel: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acu
Topics: Acute Coronary Syndrome; Aftercare; Aged; Cardiovascular Diseases; Clopidogrel; Comparative Effectiveness Research; Female; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Proton Pump Inhibitors; Purinergic P2Y Receptor Antagonists; Recurrence; Stroke; Ticlopidine; Treatment Outcome | 2016 |
Thrombogenicity of flow diverters in an ex vivo shunt model: effect of phosphorylcholine surface modification.
Topics: Animals; Arteriovenous Shunt, Surgical; Aspirin; Clopidogrel; Embolization, Therapeutic; Intracranial Aneurysm; Intracranial Thrombosis; Male; Papio anubis; Phosphorylcholine; Platelet Aggregation; Stents; Surface Properties; Ticlopidine | 2017 |
Relationship of Platelet Reactivity With Bleeding Outcomes During Long-Term Treatment With Dual Antiplatelet Therapy for Medically Managed Patients With Non-ST-Segment Elevation Acute Coronary Syndromes.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Longitudinal Studies; Male; Middle Aged; Non-ST Elevated Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Proportional Hazards Models; Randomized Controlled Trials as Topic; Ticlopidine | 2016 |
Response to the letter by Dr. Demetrios Moris "Reply to Effect of CYP2C19*2 and *3 on clinical outcome in ischemic stroke patients treated with clopidogrel".
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stroke; Ticlopidine | 2017 |
Baseline characteristics, adenosine diphosphate receptor inhibitor treatment patterns, and in-hospital outcomes of myocardial infarction patients undergoing percutaneous coronary intervention in the prospective Canadian Observational AntiPlatelet sTudy (C
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Canada; Clopidogrel; Drug Substitution; Emergency Medical Services; Emergency Service, Hospital; Female; Hemorrhage; Hospitalization; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Non-ST Elevated Myocardial Infarction; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine; Young Adult | 2016 |
Reply to effect of CYP2C19*2 and *3 on clinical outcome in ischemic stroke patients treated with Clopidogrel.
Topics: Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2017 |
Association between antithrombotic treatment and hemorrhagic stroke in patients with atrial fibrillation-a cohort study in primary care.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Cohort Studies; Female; Fibrinolytic Agents; Humans; Intracranial Hemorrhages; Male; Middle Aged; Platelet Aggregation Inhibitors; Primary Health Care; Stroke; Sweden; Ticlopidine; Warfarin | 2017 |
A 55-Year-Old Woman With Pulmonary Hypertension, Worsening Dyspnea, and Chest Pain.
Topics: Angina Pectoris; Aspirin; Clopidogrel; Compartment Syndromes; Coronary Vessels; Diagnosis, Differential; Dyspnea; Female; Humans; Hypertension, Pulmonary; Middle Aged; Patient Care Management; Platelet Aggregation Inhibitors; Pulmonary Artery; Ticlopidine; Treatment Outcome | 2014 |
Underlying mechanism and specific prevention of hemolysis-induced platelet activation.
Topics: Adenosine Diphosphate; Adult; Aged; Apyrase; Blood Group Incompatibility; Blood Platelets; Clopidogrel; Female; Hemolysis; Humans; Male; Middle Aged; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2Y12; Ticlopidine | 2017 |
Time-To-Treatment of Acute Coronary Syndrome and Unit of First Contact in the ERICO Study.
Topics: Acute Coronary Syndrome; Aged; Anticoagulants; Aspirin; Brazil; Clopidogrel; Educational Status; Female; Fibrinolytic Agents; Heparin; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Primary Health Care; Prospective Studies; Statistics, Nonparametric; Ticlopidine; Time Factors; Time-to-Treatment | 2016 |
Long-term outcomes in patients with acute coronary syndromes related to prolonging dual antiplatelet therapy more than 12 months after coronary stenting.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Databases, Factual; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemorrhage; Hospitals, Veterans; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Prosthesis Design; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome; United States; United States Department of Veterans Affairs | 2017 |
ABCC3 Polymorphisms and mRNA Expression Influence the Concentration of a Carboxylic Acid Metabolite in Patients on Clopidogrel and Aspirin Therapy.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Carboxylic Acids; Chromatography, Liquid; Clopidogrel; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Genotype; Humans; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; RNA, Messenger; Salicylic Acid; Tandem Mass Spectrometry; Ticlopidine; Up-Regulation | 2017 |
Efficacy and safety of ticagrelor versus clopidogrel with different dosage in high-risk patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Survival Rate; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
Long-term versus short-term dual antiplatelet therapy was similarly associated with a lower risk of death, stroke, or infarction in patients with acute coronary syndrome regardless of underlying kidney disease.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Creatinine; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Renal Insufficiency, Chronic; Risk Assessment; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Longitudinal treatment patterns with ADP receptor inhibitors after myocardial infarction: Insights from the Canadian Observational AntiPlatelet sTudy.
Topics: Adenosine; Aged; Canada; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Retrospective Studies; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
Life-threatening Wunderlich's syndrome with concurrent clopidogrel use.
Topics: Acute Kidney Injury; Blood Transfusion; Clopidogrel; Embolization, Therapeutic; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Syndrome; Ticlopidine | 2016 |
Cigarette Smoking, Clopidogrel Responsiveness, and Hemoglobin Level.
Topics: Cigarette Smoking; Clopidogrel; Hemoglobins; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Reply: Cigarette Smoking, Clopidogrel Responsiveness, and Hemoglobin Level.
Topics: Cigarette Smoking; Clopidogrel; Hemoglobins; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Bleeding Complications following Image-Guided Percutaneous Biopsies in Patients Taking Clopidogrel-A Retrospective Review.
Topics: Aged; Aged, 80 and over; Biopsy, Large-Core Needle; Clopidogrel; Drug Administration Schedule; Female; Hemorrhage; Humans; Image-Guided Biopsy; Incidence; Male; Middle Aged; Minnesota; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors; Vascular System Injuries | 2017 |
The effect anticoagulation status on geriatric fall trauma patients.
Topics: Accidental Falls; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Critical Care; Dipyridamole; Enoxaparin; Female; Humans; Length of Stay; Male; Middle Aged; Retrospective Studies; Ticlopidine; Warfarin; Wounds and Injuries | 2016 |
Tutorial on statistical considerations on subgroup analysis in confirmatory clinical trials.
Topics: Aspirin; Clopidogrel; Data Interpretation, Statistical; Humans; Models, Statistical; Myocardial Infarction; Protein C; Randomized Controlled Trials as Topic; Recombinant Proteins; Reproducibility of Results; Sepsis; Statistics as Topic; Stroke; Survival Analysis; Ticlopidine; Treatment Outcome | 2017 |
Influence of a low dosage of clopidogrel on platelet function in cats as measured by the platelet function analyser PFA-100 and the multiplate analyser.
Topics: Animals; Blood Platelets; Cats; Clopidogrel; Dose-Response Relationship, Drug; Electric Impedance; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2016 |
High platelet reactivity affects the clinical outcomes of patients undergoing percutaneous coronary intervention.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine; Time Factors | 2016 |
Vascular disease: Ticagrelor not superior to clopidogrel for PAD.
Topics: Clopidogrel; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2017 |
Pharmacodynamic and cytogenetic evaluation in CYP2C19*2 and CYP2C19*3 allelomorphism in South Indian population with clopidogrel therapy.
Topics: Alleles; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; DNA; Female; Gene Frequency; Genotype; Humans; India; Male; Middle Aged; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Ticlopidine; Treatment Outcome | 2017 |
Mortality in patients who discontinue low-dose acetylsalicylic acid therapy after upper gastrointestinal bleeding.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Primary Health Care; Proportional Hazards Models; Retrospective Studies; Risk Factors; Sex Factors; Ticlopidine; Time Factors; United Kingdom | 2017 |
Prognostic Factors in Patients With Stemi Undergoing Primary PCI in the Clopidogrel Era: Role of Dual Antiplatelet Therapy at Admission and the Smoking Paradox on Long-Term Outcome.
Topics: Aged; Belgium; Clopidogrel; Female; Hospitalization; Humans; Italy; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Smoking; ST Elevation Myocardial Infarction; Ticlopidine | 2017 |
W1, a Novel Oral Antiplatelet Agent With Less Resistance Than Clopidogrel.
Topics: Administration, Oral; Animals; Aspirin; Clopidogrel; Drug Combinations; Drug Resistance; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation; Rats; Rats, Wistar; Ticlopidine | 2017 |
Platelet aggregation and risk of stent thrombosis or bleeding in interventionally treated diabetic patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Diabetes Mellitus; Female; Follow-Up Studies; Graft Occlusion, Vascular; Hemorrhage; Humans; Incidence; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Poland; Prospective Studies; Thrombosis; Ticlopidine | 2016 |
Impact of an Interaction Between Clopidogrel and Selective Serotonin Reuptake Inhibitors.
Topics: Aged; Cerebral Hemorrhage; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19 Inhibitors; Databases, Factual; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Stroke; Ticlopidine | 2017 |
Decade-long temporal trends in the utilization of preventive medicines by centenarians.
Topics: Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Cross-Sectional Studies; Drug Utilization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Preventive Medicine; Ticlopidine | 2017 |
Switching of adenosine diphosphate receptor inhibitor after hospital discharge among myocardial infarction patients: Insights from the Treatment with Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after
Topics: Adenosine; Adenosine Diphosphate; Aged; Cardiovascular Diseases; Clopidogrel; Drug Substitution; Female; Hemorrhage; Humans; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Patient Discharge; Patient Preference; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P1 Receptor Antagonists; Ticagrelor; Ticlopidine | 2017 |
Influence of low-dose proton pump inhibitors administered concomitantly or separately on the anti-platelet function of clopidogrel.
Topics: Adult; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Japan; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Ticlopidine; Time Factors | 2017 |
Genomewide Association Study Identifies Novel Genetic Loci That Modify Antiplatelet Effects and Pharmacokinetics of Clopidogrel.
Topics: Aged; ATP Binding Cassette Transporter 1; Biotransformation; China; Clopidogrel; Coronary Disease; Female; Genetic Loci; Genome-Wide Association Study; Humans; Male; Microsomes, Liver; Middle Aged; Models, Biological; Nonlinear Dynamics; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Site-Specific DNA-Methyltransferase (Adenine-Specific); Ticlopidine; Treatment Outcome | 2017 |
Latin American Clinical Epidemiology Network Series - Paper 8: Ticagrelor was cost-effective vs. clopidogrel in acute coronary syndrome in Chile.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Cost-Benefit Analysis; Epidemiologic Studies; Female; Humans; Latin America; Male; Middle Aged; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2017 |
Proposal of a "gradient model" to evaluate residual platelet activity on antiplatelet therapy: A pilot study.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Drug Resistance; Electric Impedance; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2017 |
Nonsteroidal anti-inflammatory drugs-induced small bowel enteropathy and obscure gastrointestinal bleeding.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Aspirin; Capsule Endoscopy; Case-Control Studies; Clopidogrel; Comorbidity; Coronary Disease; Female; Gastrointestinal Hemorrhage; Humans; Intestinal Diseases; Logistic Models; Male; Multivariate Analysis; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2018 |
Switching from ticagrelor to clopidogrel: New answers and further questions.
Topics: Adenosine; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine | 2017 |
Platelet aggregation and the risk of stent thrombosis or bleeding in elective percutaneous coronary intervention patients.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Thrombosis; Elective Surgical Procedures; Female; Hemorrhage; Humans; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Stents; Ticlopidine | 2017 |
Contemporary Trends in Oral Antiplatelet Agent Use in Patients Treated with Percutaneous Coronary Intervention for Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Aged; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Patient Outcome Assessment; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticagrelor; Ticlopidine | 2017 |
Clinical Impact of Pharmacogenomics of Clopidogrel in Stroke.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Pharmacogenetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2017 |
Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.
Topics: Adenosine; Animals; Blood Coagulation; Blood Platelets; Carotid Artery Injuries; Cells, Cultured; Clopidogrel; Disease Models, Animal; Down-Regulation; Endothelial Cells; Equilibrative Nucleoside Transporter 1; Fibrinolytic Agents; Humans; Male; Mice, Inbred C57BL; Platelet Aggregation Inhibitors; Proteasome Endopeptidase Complex; Proteolysis; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboplastin; Thrombosis; Ticagrelor; Ticlopidine; Time Factors; Tumor Necrosis Factor-alpha | 2017 |
Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines.
Topics: Anticoagulants; Antidepressive Agents; Antimetabolites, Antineoplastic; Antitubercular Agents; Arylamine N-Acetyltransferase; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Depressive Disorder; Genotype; Isoniazid; Laboratories, Hospital; Methyltransferases; Pharmacogenomic Testing; Platelet Aggregation Inhibitors; Pulmonary Embolism; Ticlopidine; Tuberculosis; Vitamin K Epoxide Reductases; Warfarin | 2017 |
Impact of Cerebrovascular Events Older Than One Year on Ischemic and Bleeding Outcomes With Cangrelor in Percutaneous Coronary Intervention.
Topics: Adenosine Monophosphate; Aged; Brain Ischemia; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Female; Hemorrhage; Humans; Ischemic Attack, Transient; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Antiplatelet Strategies and Outcomes in Patients with Noncardioembolic Ischemic Stroke from a Real-World Study with a Five-Year Follow-Up.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; China; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Hemorrhage; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Secondary Prevention; Stroke; Ticlopidine; Treatment Outcome | 2017 |
Submucosal Hematoma of the Sigmoid Colon Due to Anticoagulation Therapy.
Topics: Anticoagulants; Aspirin; Clopidogrel; Colon, Sigmoid; Colonoscopy; Diagnosis, Differential; Hematoma; Humans; Intestinal Mucosa; Male; Middle Aged; Sigmoid Diseases; Ticlopidine; Tomography, X-Ray Computed | 2017 |
Ticagrelor Compared with Clopidogrel Increased Adenosine and Cyclic Adenosine Monophosphate Plasma Concentration in Acute Coronary Syndrome Patients.
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Deaminase; Aged; Clopidogrel; Cyclic AMP; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Ticagrelor; Ticlopidine | 2017 |
Pump Thrombosis following HeartMate II Left Ventricular Assist Device Implantation in a Patient with Aspirin and Plavix Resistance.
Topics: Aged; Aspirin; Clopidogrel; Drug Resistance; Heart Failure; Heart-Assist Devices; Humans; Male; Platelet Aggregation Inhibitors; Prosthesis Failure; Retrospective Studies; Thrombosis; Ticlopidine | 2016 |
Percutaneous left atrial appendage closure followed by single antiplatelet therapy: Short- and mid-term outcomes.
Topics: Aged; Aged, 80 and over; Aspirin; Atrial Appendage; Atrial Fibrillation; Cardiac Catheterization; Clopidogrel; Drug Administration Schedule; Female; France; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stroke; Thrombosis; Ticlopidine; Time Factors; Tomography, X-Ray Computed; Treatment Outcome | 2017 |
Platelet reactivity in human immunodeficiency virus infected patients on dual antiplatelet therapy for an acute coronary syndrome: the EVERE2ST-HIV study.
Topics: Acute Coronary Syndrome; Adenosine; Anti-HIV Agents; Aspirin; Blood Platelets; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Recurrence; Risk Factors; Ticagrelor; Ticlopidine | 2017 |
Ticagrelor, but not clopidogrel active metabolite, displays antithrombotic properties in the left atrial endocardium.
Topics: Adenosine; Antithrombins; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Endocardium; Heart Atria; Humans; Plasminogen Activator Inhibitor 1; Purinergic P2Y Receptor Antagonists; Thromboplastin; Ticagrelor; Ticlopidine; Tumor Necrosis Factor-alpha | 2017 |
Concomitant use of calcium channel blockers with dual antiplatelet therapy and re-hospitalization for acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Calcium Channel Blockers; Clopidogrel; Databases, Factual; Drug Interactions; Drug Therapy, Combination; Female; Guideline Adherence; Humans; Male; Middle Aged; Patient Readmission; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proportional Hazards Models; Secondary Prevention; Taiwan; Ticlopidine | 2017 |
Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients.
Topics: Alleles; Aryldialkylphosphatase; Aspirin; ATP Binding Cassette Transporter, Subfamily B; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Ticlopidine | 2017 |
Dual Antiplatelet Therapy Versus Aspirin Monotherapy in Diabetics With Multivessel Disease Undergoing CABG: FREEDOM Insights.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Cause of Death; Clopidogrel; Diabetic Angiopathies; Drug Therapy, Combination; Drug Utilization; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Care; Postoperative Complications; Proportional Hazards Models; Stroke; Survival Rate; Ticlopidine | 2017 |
Spontaneous retroperitoneal haematoma resulting in bowel ischaemia.
Topics: Aged; Clopidogrel; Hematoma; Humans; Male; Mesenteric Ischemia; Peritonitis; Platelet Aggregation Inhibitors; Rectal Diseases; Rectum; Retroperitoneal Space; Ticlopidine; Tomography, X-Ray Computed | 2017 |
Characterization of Three CYP2C19 Gene Variants by MassARRAY and Point of Care Techniques: Experience from a Czech Centre.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Cytochrome P-450 CYP2C19; Czech Republic; Female; Genetic Variation; Genotype; Humans; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Percutaneous Coronary Intervention; Pharmacogenetics; Phenotype; Platelet Aggregation Inhibitors; Point-of-Care Systems; Ticlopidine | 2016 |
Predictive value of non-fasting remnant cholesterol for short-term outcome of diabetics with new-onset stable coronary artery disease.
Topics: Aged; Biomarkers; C-Reactive Protein; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clopidogrel; Cohort Studies; Coronary Angiography; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Fibrinogen; Follow-Up Studies; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Neutrophils; Prognosis; Proportional Hazards Models; ROC Curve; Ticlopidine; Treatment Outcome | 2017 |
Effect of Clopidogrel by Smoking Status on Secondary Stroke Prevention.
Topics: Aspirin; Clinical Trials as Topic; Clopidogrel; Datasets as Topic; Drug Therapy, Combination; Humans; Kaplan-Meier Estimate; Multicenter Studies as Topic; Myocardial Infarction; Platelet Aggregation Inhibitors; Proportional Hazards Models; Risk Factors; Secondary Prevention; Smoking; Stroke; Ticlopidine | 2017 |
Additive antithrombotic effect of ASP6537, a selective cyclooxygenase (COX)-1 inhibitor, in combination with clopidogrel in guinea pigs.
Topics: Administration, Oral; Animals; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Synergism; Fibrinolytic Agents; Guinea Pigs; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Triazoles | 2017 |
Portal Vein Thrombosis in Patients With Cirrhosis Undergoing Elective Transjugular Intrahepatic Portosystemic Shunt: Risk Factors, Warfarin Efficacy, and Clinical Outcomes.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Elective Surgical Procedures; Female; Fibrosis; Humans; Male; Middle Aged; Portal Vein; Portasystemic Shunt, Transjugular Intrahepatic; Risk Factors; Ticlopidine; Treatment Outcome; Venous Thrombosis; Warfarin | 2018 |
Validation of a New ELISA-Based Vasodilator-Associated Stimulated Phosphoprotein Phosphorylation Assay to Assess Platelet Reactivity Index in a Chinese Population.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Aged; Asian People; Cell Adhesion Molecules; Clopidogrel; Cryopreservation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine; Vasodilator Agents | 2018 |
Risk Factors of Subacute Thrombosis After Intracranial Stenting for Symptomatic Intracranial Arterial Stenosis.
Topics: Adult; Aged; Aspirin; Clopidogrel; Constriction, Pathologic; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Stents; Thrombosis; Ticlopidine | 2017 |
Clopidogrel and ischemic stroke outcomes by smoking status: Smoker's paradox?
Topics: Aspirin; Brain Ischemia; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Smoking; Stroke; Ticlopidine; Treatment Outcome | 2017 |
Editor's Choice - Dual Antiplatelet Therapy Improves Outcome in Diabetic Patients Undergoing Endovascular Femoropopliteal Stenting for Critical Limb Ischaemia.
Topics: Adult; Aged; Aged, 80 and over; Amputation, Surgical; Aspirin; Clopidogrel; Constriction, Pathologic; Critical Illness; Diabetic Angiopathies; Drug Therapy, Combination; Endovascular Procedures; Female; Femoral Artery; Humans; Ischemia; Kaplan-Meier Estimate; Limb Salvage; Male; Middle Aged; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Popliteal Artery; Proportional Hazards Models; Registries; Retrospective Studies; Risk Factors; Stents; Sweden; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
The CYP2C19*2 and CYP2C19*17 Polymorphisms play a Vital Role in Clopidogrel Responsiveness after Percutaneous Coronary Intervention: A Pharmacogenomics Study.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Postoperative Complications; Sequence Analysis, DNA; Stents; Thrombosis; Ticlopidine; Treatment Outcome; Turkey | 2017 |
The effect of correcting VerifyNow P2Y12 assay results for hematocrit in patients undergoing percutaneous coronary interventions.
Topics: Aged; Area Under Curve; Blood Platelets; Clopidogrel; Female; Follow-Up Studies; Hematocrit; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Receptors, Purinergic P2Y12; Risk; ROC Curve; Sensitivity and Specificity; Thrombosis; Ticlopidine | 2017 |
The budget impact of using enteric-coated aspirin 325 mg + immediate-release omeprazole 40 mg to prevent recurrent cardiovascular events.
Topics: Adult; Aged; Aspirin; Budgets; Cardiovascular Diseases; Clopidogrel; Drug Combinations; Female; Gastrointestinal Diseases; Humans; Male; Markov Chains; Medication Adherence; Middle Aged; Models, Econometric; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Secondary Prevention; Ticlopidine | 2017 |
Novel role of platelet reactivity in adverse left ventricular remodelling after ST-segment elevation myocardial infarction: The REMODELING Trial.
Topics: Aged; Aspirin; Biomarkers; Blood Platelets; C-Reactive Protein; Chi-Square Distribution; Clopidogrel; Echocardiography; Female; Humans; Inflammation Mediators; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; ST Elevation Myocardial Infarction; Stents; Ticlopidine; Time Factors; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling | 2017 |
Pulmonary alveolar hemorrhage mimicking a pneumopathy: a rare complication of dual antiplatelet therapy for ST elevation myocardial infarction.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Lung Diseases; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Pulmonary Alveoli; ST Elevation Myocardial Infarction; Ticlopidine; Tomography, X-Ray Computed | 2016 |
Platelet reactivity in patients carrying the e-NOS G894T polymorphism after a loading dose of aspirin plus clopidogrel.
Topics: Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2017 |
Dual Antiplatelet Therapy Does Not Increase the Risk of Bleeding After Carotid Endarterectomy: Results of a Prospective Study.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aspirin; Asymptomatic Diseases; Carotid Stenosis; Clopidogrel; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Angiotensin-Converting Enzyme Inhibitors' Influence on Antiplatelet Therapy of Clopidogrel in ACS.
Topics: Acute Coronary Syndrome; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Carboxylic Ester Hydrolases; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine | 2016 |
Impact of the CYP2C19 Gene Polymorphism on Clopidogrel Personalized Drug Regimen and the Clinical Outcomes.
Topics: Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2016 |
Dipeptidyl Peptidase-4 Inhibitor-Associated Risk of Bleeding: An Evaluation of Reported Adverse Events.
Topics: Adverse Drug Reaction Reporting Systems; Aspirin; Clopidogrel; Dipeptidyl-Peptidase IV Inhibitors; Hemorrhage; Humans; Hypoglycemic Agents; Metformin; Odds Ratio; Platelet Aggregation Inhibitors; Retrospective Studies; Risk; Ticlopidine | 2017 |
Dual Antiplatelet Therapy and Clinical Outcomes after Coronary Drug-Eluting Stent Implantation in Patients on Hemodialysis.
Topics: Aged; Aspirin; Brain Ischemia; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Kidney Failure, Chronic; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Platelet Aggregation Inhibitors; Propensity Score; Renal Dialysis; Retrospective Studies; Stroke; Survival Rate; Taiwan; Ticlopidine | 2017 |
Management of a Patient Requiring Intrathecal Drain Insertion and Removal in the Setting of Concomitant Dual Antiplatelet Therapy With Clopidogrel and Aspirin: A Case Report.
Topics: Aspirin; Catheters, Indwelling; Clopidogrel; Device Removal; Drainage; Drug Therapy, Combination; Endovascular Procedures; Hematoma, Epidural, Spinal; Humans; Hydrocephalus; Intracranial Aneurysm; Intracranial Thrombosis; Male; Metals; Middle Aged; Platelet Aggregation Inhibitors; Prosthesis Design; Risk Factors; Stents; Subarachnoid Hemorrhage; Ticlopidine; Treatment Outcome | 2017 |
Effect of antiplatelet therapy on aneurysmal sac expansion associated with type II endoleaks after endovascular aneurysm repair.
Topics: Aged; Aged, 80 and over; Anticoagulants; Aortic Aneurysm, Abdominal; Aortography; Aspirin; Blood Vessel Prosthesis Implantation; Chi-Square Distribution; Clopidogrel; Computed Tomography Angiography; Contrast Media; Databases, Factual; Drug Therapy, Combination; Endoleak; Endovascular Procedures; Female; Humans; Kaplan-Meier Estimate; Male; Platelet Aggregation Inhibitors; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Spain; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Sex Differences in the Clinical Impact of High Platelet Reactivity After Percutaneous Coronary Intervention With Drug-Eluting Stents: Results From the ADAPT-DES Study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents).
Topics: Aged; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Germany; Hemorrhage; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Propensity Score; Prospective Studies; Purinergic P2Y Receptor Antagonists; Registries; Risk Factors; Sex Factors; Ticlopidine; Time Factors; Treatment Outcome; United States | 2017 |
Aspirin desensitization in patients with coronary artery disease: Cost savings.
Topics: Aspirin; Clopidogrel; Coronary Disease; Cost Savings; Desensitization, Immunologic; Drug Hypersensitivity; Drug Substitution; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Salicylates; Ticlopidine | 2017 |
Comparison of Platelet Reactivity in Black Versus White Patients With Acute Coronary Syndromes After Treatment With Ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Black People; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; White People | 2017 |
Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response.
Topics: Adult; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 3; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genome-Wide Association Study; Humans; Male; Middle Aged; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine | 2017 |
The Effect of Combined Aspirin and Clopidogrel Treatment on Cancer Incidence.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Incidence; Male; Middle Aged; Neoplasms; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2017 |
Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients.
Topics: Acute Coronary Syndrome; Adenosine; Aged; China; Clopidogrel; Coronary Artery Bypass; Female; Follow-Up Studies; Humans; Logistic Models; Male; Medication Adherence; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Practice Guidelines as Topic; Prospective Studies; Purinergic P2Y Receptor Antagonists; Recurrence; Risk Factors; Secondary Prevention; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
[Correlation between cytochrome 3A4+894C>T P450 gene polymorphism and outcomes of coronary intervention in patients with acute coronary syndrome].
Topics: Acute Coronary Syndrome; Alleles; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP3A; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Ticlopidine | 2016 |
Drug interaction: Clopidogrel and PPIs.
Topics: Clopidogrel; Drug Interactions; Esomeprazole; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine | 2017 |
Reversible thrombotic mitral valve stenosis after transcatheter mitral valve replacement (TMVR): Is life-long anticoagulation therapy necessary?
Topics: Aged; Anticoagulants; Aspirin; Bioprosthesis; Cardiac Catheterization; Clopidogrel; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Mitral Valve; Mitral Valve Stenosis; Postoperative Complications; Thrombosis; Ticlopidine; Treatment Outcome; Warfarin | 2017 |
Perioperative clopidogrel is associated with increased bleeding and blood transfusion at the time of lower extremity bypass.
Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Chi-Square Distribution; Clopidogrel; Databases, Factual; Drug Administration Schedule; Female; Hospital Mortality; Humans; Logistic Models; Lower Extremity; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Operative Time; Perioperative Period; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Reoperation; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Transfusion Reaction; Treatment Outcome; United States; Vascular Surgical Procedures | 2017 |
Clopidogrel-Paclitaxel Drug-Drug Interaction: A Pharmacoepidemiologic Study.
Topics: Aged; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C8; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Liver; Male; Middle Aged; Paclitaxel; Peripheral Nervous System Diseases; Pharmacoepidemiology; Platelet Aggregation Inhibitors; Retrospective Studies; Severity of Illness Index; Ticlopidine | 2017 |
Platelet turnover predicts outcome after coronary intervention.
Topics: Aged; Aged, 80 and over; Aspirin; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Chi-Square Distribution; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Linear Models; Logistic Models; Male; Mean Platelet Volume; Microfilament Proteins; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Antiplatelet drug resistance did not increase the thromboembolic events after stent-assisted coiling of unruptured intracranial aneurysm: a single center experience of 99 cases.
Topics: Adult; Aged; Aspirin; Blood Vessel Prosthesis; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2017 |
Improved Pig Model to Evaluate Heart Valve Thrombosis.
Topics: Animals; Aspirin; Blood Coagulation; Blood Platelets; Clopidogrel; Disease Models, Animal; Heart Valve Diseases; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation; Humans; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Swine; Thrombosis; Ticlopidine | 2016 |
Out-of-hospital cardiac arrest and stent thrombosis: Ticagrelor versus clopidogrel in patients with primary percutaneous coronary intervention under mild therapeutic hypothermia.
Topics: Adenosine; Aged; Clopidogrel; Coronary Thrombosis; Humans; Hypothermia, Induced; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Stents; Ticagrelor; Ticlopidine | 2017 |
Effect of Clopidogrel on Thrombus Formation in an Ex Vivo Parallel Plate Flow Chamber Model Cannot Be Reversed by Addition of Platelet Concentrates or vWF Concentrate.
Topics: Anticoagulants; Blood Coagulation; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Humans; Perfusion; Platelet Aggregation Inhibitors; Protein Array Analysis; Thrombosis; Ticlopidine; Treatment Outcome; von Willebrand Factor | 2017 |
Association of Antithrombotic Drug Use With Subdural Hematoma Risk.
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Case-Control Studies; Clopidogrel; Comorbidity; Denmark; Drug Therapy, Combination; Female; Fibrinolytic Agents; Hematoma, Subdural; Humans; Incidence; Male; Middle Aged; Odds Ratio; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Vitamin K; Young Adult | 2017 |
Design and Development of Clopidogrel Bisulfate Gastroretentive Osmotic Formulation Using Quality by Design Tools.
Topics: Biological Availability; Clopidogrel; Delayed-Action Preparations; Drug Compounding; Drug Liberation; Gastric Mucosa; Osmosis; Solubility; Tablets; Ticlopidine | 2017 |
Mortality and cancer after 12 versus 30 months dual antiplatelet therapy. The Korean Outcomes Registry Evaluating Antithrombotics (KOREA).
Topics: Aged; Aspirin; Cause of Death; Chi-Square Distribution; Clopidogrel; Disease-Free Survival; Drug Administration Schedule; Drug Therapy, Combination; Female; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Neoplasms; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Propensity Score; Proportional Hazards Models; Registries; Republic of Korea; Retrospective Studies; Risk Assessment; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Clopidogrel, prasugrel, or ticagrelor use and clinical outcome in patients with acute coronary syndrome: A nationwide long-term registry analysis from 2009 to 2014.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Austria; Clopidogrel; Drug Therapy, Combination; Female; Hospitalization; Humans; Incidence; Male; Medication Therapy Management; Patient Discharge; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Recurrence; Survival Analysis; Ticagrelor; Ticlopidine | 2017 |
Preoperative Use of Clopidogrel Does Not Affect Outcomes for Femoral Neck Fractures Treated With Hemiarthroplasty.
Topics: Adult; Aged; Aged, 80 and over; Blood Loss, Surgical; Cerebrovascular Disorders; Clopidogrel; Comorbidity; Female; Femoral Neck Fractures; Hemiarthroplasty; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Period; Retrospective Studies; Ticlopidine | 2017 |
A randomized clinical trial comparing long-term clopidogrel vs aspirin monotherapy beyond dual antiplatelet therapy after drug-eluting coronary stent implantation: Design and rationale of the Harmonizing Optimal Strategy for Treatment of coronary artery s
Topics: Acute Coronary Syndrome; Aspirin; Cause of Death; Clopidogrel; Coronary Stenosis; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Mortality; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Longer-term oral antiplatelet use in stable post-myocardial infarction patients: Insights from the long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease (TIGRIS) observational study.
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; International Cooperation; Long Term Adverse Effects; Male; Middle Aged; Outcome Assessment, Health Care; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Risk Factors; ST Elevation Myocardial Infarction; Ticlopidine | 2017 |
Determinants of high on-treatment platelet reactivity and agreement between VerifyNow and Multiplate assays.
Topics: Aged; Aged, 80 and over; Angioplasty; ATP Binding Cassette Transporter, Subfamily B; Biological Assay; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug-Eluting Stents; Female; Gene Expression; Hematocrit; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Polymorphism, Genetic; Thrombosis; Ticlopidine | 2017 |
State transition model: vorapaxar added to standard antiplatelet therapy to prevent thrombosis post myocardial infarction or peripheral artery disease.
Topics: Aspirin; Clopidogrel; Female; Hemorrhage; Humans; Lactones; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Pyridines; Quality of Life; Quality-Adjusted Life Years; Secondary Prevention; Stroke; Thrombosis; Ticlopidine | 2017 |
Association of genetic variant and platelet function in patients undergoing neuroendovascular stenting.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Aspirin; Brain Ischemia; Clopidogrel; Female; Genetic Variation; Genotype; Humans; Linkage Disequilibrium; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Recurrence; Stents; Stroke; Thrombelastography; Ticlopidine | 2017 |
Platelet Reactivity and Clinical Outcomes After Coronary Artery Implantation of Drug-Eluting Stents in Subjects With Peripheral Arterial Disease: Analysis From the ADAPT-DES Study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents).
Topics: Aged; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Peripheral Arterial Disease; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Propensity Score; Proportional Hazards Models; Prospective Studies; Purinergic P2Y Receptor Antagonists; Registries; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
[Platelet Metabolism in Clopidogrel Resistant and Sensitive Patients With Ischemic Heart Disease].
Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Drug Resistance; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2016 |
Clinical events beyond one year after an acute coronary syndrome: insights from the RECLOSE 2-ACS study.
Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Relationship between thromboelastography and long-term ischemic events as gauged by the response to clopidogrel in patients undergoing elective percutaneous coronary intervention.
Topics: Clopidogrel; Coronary Disease; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; ROC Curve; Thrombelastography; Ticlopidine | 2017 |
Administration of Ticagrelor and Double-Dose Clopidogrel Based on Platelet Reactivity Determined by VerifyNow-P2Y12 for Chinese Subjects After Elective PCI.
Topics: Adenosine; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Postoperative Complications; Purinergic P2Y Receptor Antagonists; Thrombosis; Ticagrelor; Ticlopidine | 2017 |
The Feasibility and Safety of Separate Carotid Artery Stenting Using the Restrict Protective Method for Bilateral Carotid Stenosis.
Topics: Adult; Aged; Aged, 80 and over; Angiography, Digital Subtraction; Carotid Arteries; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Endovascular Procedures; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Ticlopidine; Ultrasonography, Doppler | 2017 |
Prediction of high on-treatment platelet reactivity in clopidogrel-treated patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Gene Regulatory Networks; Humans; Machine Learning; Male; Middle Aged; Neural Networks, Computer; Platelet Activation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Ticlopidine; Treatment Outcome | 2017 |
Policy objective of generic medicines from the investment perspective: The case of clopidogrel.
Topics: Clopidogrel; Developing Countries; Drug Costs; Drugs, Generic; Europe; Health Policy; Humans; Platelet Aggregation Inhibitors; Socioeconomic Factors; Ticlopidine | 2017 |
The difference in association between aspirin use and other thrombocyte aggregation inhibitors and survival in patients with colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Colorectal Neoplasms; Dipyridamole; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Netherlands; Platelet Aggregation Inhibitors; Survival Analysis; Ticlopidine | 2017 |
Impact of Diabetes Mellitus on the Pharmacodynamic Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Acute Coronary Syndrome Patients Undergoing Ad Hoc Percutaneous Coronary Intervention.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Blood Platelets; Clopidogrel; Comorbidity; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticagrelor; Ticlopidine; Troponin | 2017 |
The risk of clopidogrel resistance is associated with ABCB1 polymorphisms but not promoter methylation in a Chinese Han population.
Topics: Aged; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; DNA Methylation; Drug Resistance; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; Male; Middle Aged; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Serum Albumin; Sex Characteristics; Ticlopidine; Vascular System Injuries | 2017 |
Use of Aspirin and P2Y12 Response Assays in Detecting Reversal of Platelet Inhibition With Platelet Transfusion in Patients With Traumatic Brain Injury on Antiplatelet Therapy.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Brain Injuries, Traumatic; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Receptors, Purinergic P2Y12; Ticlopidine | 2017 |
Utility of the Aspirin and P2Y12 Response Assays to Determine the Effect of Antiplatelet Agents on Platelet Reactivity in Traumatic Brain Injury.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Brain Injuries, Traumatic; Clopidogrel; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2017 |
Twelve-month outcome of patients with an established indication for oral anticoagulation undergoing coronary artery stenting and stratified by the baseline risk of bleeding: Insights from the Warfarin and Coronary Stenting (War-Stent) Registry.
Topics: Administration, Oral; Adult; Aged; Anticoagulants; Clopidogrel; Coronary Artery Disease; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Stents; Thrombolytic Therapy; Ticlopidine; Treatment Outcome; Warfarin; Young Adult | 2017 |
Effects of clopidogrel on inflammatory cytokines and adhesion molecules in human endothelial cells: Role of nitric oxide mediating pleiotropic effects.
Topics: Cell Adhesion Molecules; Chemokine CCL2; Clopidogrel; Cytokines; Endothelial Cells; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Nitric Oxide; Nitric Oxide Synthase Type III; Platelet Aggregation Inhibitors; Ticlopidine | 2017 |
Incidence and outcome of switching of oral platelet P2Y12 receptor inhibitors in patients with acute coronary syndromes undergoing percutaneous coronary intervention: the SCOPE registry.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Blood Platelets; Clopidogrel; Female; Hemorrhage; Humans; Incidence; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2017 |
Short Communication: Evaluation of nephrotoxicity by aspirin-clopidogrel combination therapy in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Biomarkers; Blood Urea Nitrogen; Clopidogrel; Creatinine; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Platelet Aggregation Inhibitors; Risk Assessment; Ticlopidine; Time Factors; Treatment Outcome; Uric Acid | 2016 |
Gene variants in responsiveness to clopidogrel have no impact on clinical outcomes in Chinese patients undergoing percutaneous coronary intervention - A multicenter study.
Topics: Acute Coronary Syndrome; Aged; Asian People; Clopidogrel; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2017 |
GPIIb-IIIa Receptor Inhibitors in Acute Coronary Syndrome Patients Presenting With Cardiogenic Shock and/or After Cardiopulmonary Resuscitation.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Cardiopulmonary Resuscitation; Cause of Death; Clopidogrel; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Risk Factors; Shock, Cardiogenic; Slovenia; Survival Rate; Ticagrelor; Ticlopidine; Time Factors | 2018 |
Ticagrelor versus clopidogrel in real-world patients with ST elevation myocardial infarction: 1-year results by propensity score analysis.
Topics: Adenosine; Aged; Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Hospital Mortality; Humans; Italy; Male; Middle Aged; Platelet Aggregation Inhibitors; Propensity Score; Purinergic P2Y Receptor Antagonists; Registries; Retrospective Studies; ST Elevation Myocardial Infarction; Survival Rate; Ticagrelor; Ticlopidine; Time Factors | 2017 |
On-clopidogrel platelet reactivity as predictor for long-term clinical outcome in patients after planned discontinuation of clopidogrel.
Topics: Aged; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Administration Schedule; Drug Resistance; Female; Germany; Humans; Kaplan-Meier Estimate; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Associations between P2RY12 gene polymorphisms and risks of clopidogrel resistance and adverse cardiovascular events after PCI in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Secondary Prevention; Ticlopidine | 2017 |
Malignant stroke in a ticagrelor non-responder as a complication following aneurysm treatment with the Pipeline Embolization Device™.
Topics: Adenosine; Aged; Aspirin; Carotid Artery, Internal; Cerebral Angiography; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Stroke; Ticagrelor; Ticlopidine | 2017 |
Recommendations on the Clinical Use of Compound Danshen Dripping Pills.
Topics: Angina Pectoris; Aspirin; Camphanes; Clopidogrel; Coronary Disease; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Retinopathy; Drugs, Chinese Herbal; Humans; Meta-Analysis as Topic; Panax notoginseng; Salvia miltiorrhiza; Ticlopidine | 2017 |
The association between high on-treatment platelet reactivity and early recurrence of ischemic events after minor stroke or TIA.
Topics: Adult; Aged; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Aggregation Inhibitors; Prevalence; Prospective Studies; Recurrence; Stroke; Thrombelastography; Ticlopidine | 2017 |
Use of Platelet Function Testing Before Pipeline Embolization Device Placement: A Multicenter Cohort Study.
Topics: Adenosine; Adolescent; Adult; Aged; Aged, 80 and over; Clopidogrel; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Intracranial Embolism; Intracranial Thrombosis; Male; Middle Aged; Outcome Assessment, Health Care; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Ticagrelor; Ticlopidine; Young Adult | 2017 |
Physiologically Based Pharmacokinetic Modeling Suggests Limited Drug-Drug Interaction Between Clopidogrel and Dasabuvir.
Topics: 2-Naphthylamine; Antiviral Agents; Area Under Curve; Clopidogrel; Cytochrome P-450 CYP2C8; Drug Interactions; Glucuronides; Humans; In Vitro Techniques; Models, Biological; Sulfonamides; Ticlopidine; Uracil | 2017 |
Contemporary Trends and Outcomes Associated With the Preprocedural Use of Oral P2Y12 Inhibitors in Patients Undergoing Percutaneous Coronary Intervention: Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2).
Topics: Adenosine; Aged; Blue Cross Blue Shield Insurance Plans; Clopidogrel; Drug Utilization Review; Ethnicity; Female; Graft Occlusion, Vascular; Hemorrhage; Hospital Mortality; Humans; Male; Michigan; Middle Aged; Outcome and Process Assessment, Health Care; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Preoperative Period; Purinergic P2Y Receptor Antagonists; Stents; Ticagrelor; Ticlopidine; Time Factors | 2017 |
Disaggregation Following Agonist-Induced Platelet Activation in Patients on Dual Antiplatelet Therapy.
Topics: Adenosine; Aged; Aspirin; Blood Platelets; Clopidogrel; Drug Monitoring; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Reproducibility of Results; Signal Transduction; Stents; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
Novel oral anticoagulants and trauma: The results of a prospective American Association for the Surgery of Trauma Multi-Institutional Trial.
Topics: Administration, Oral; Aged; Anticoagulants; Aspirin; Clopidogrel; Dabigatran; Female; Humans; Injury Severity Score; Intracranial Hemorrhages; Male; Platelet Aggregation Inhibitors; Prospective Studies; Pyrazoles; Pyridones; Rivaroxaban; Ticlopidine; Trauma Centers; Warfarin; Wounds and Injuries; Wounds, Nonpenetrating | 2017 |
Previous hypertensive hemorrhage increases the risk for bleeding and ischemia for PCI patients on dual antiplatelet therapy.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Case-Control Studies; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Ischemia; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2017 |
Assessment of 'on-treatment platelet reactivity' and relationship with cerebral micro-embolic signals in asymptomatic and symptomatic carotid stenosis.
Topics: Aged; Aspirin; Brain; Carotid Stenosis; Case-Control Studies; Clopidogrel; Disease Progression; Female; Humans; Intracranial Embolism; Longitudinal Studies; Male; Middle Aged; Pilot Projects; Platelet Aggregation Inhibitors; Prevalence; Proof of Concept Study; Ticlopidine; Ultrasonography, Doppler, Transcranial | 2017 |
Vitamin D Binding Protein rs7041 polymorphism and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Gene Frequency; Genotype; Heterozygote; Homozygote; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Pharmacogenetics; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Risk Factors; Ticagrelor; Ticlopidine; Treatment Outcome; Vitamin D Deficiency; Vitamin D-Binding Protein | 2017 |
Comparative Effectiveness and Safety Analysis of Dual Antiplatelet Therapies Within an Integrated Delivery System.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Delivery of Health Care, Integrated; Female; Hemorrhage; Humans; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Propensity Score; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Retrospective Studies; Safety; Ticagrelor; Ticlopidine | 2017 |
Effects of four novel genetic polymorphisms on clopidogrel efficacy in Chinese acute coronary syndromes patients.
Topics: Acute Coronary Syndrome; Aged; Case-Control Studies; Clopidogrel; Female; Genetic Loci; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine; Treatment Outcome | 2017 |
Total Thrombus-formation Analysis System Predicts Periprocedural Bleeding Events in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Coagulation Tests; Clopidogrel; Coronary Artery Disease; Female; Hemorrhage; Humans; Intraoperative Complications; Male; Microchip Analytical Procedures; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Prasugrel Hydrochloride; Risk Assessment; Ticlopidine | 2017 |
Utilizing PBPK Modeling to Evaluate the Potential of a Significant Drug-Drug Interaction Between Clopidogrel and Dasabuvir: A Scientific Perspective.
Topics: 2-Naphthylamine; Antiviral Agents; Clopidogrel; Cytochrome P-450 CYP2C8; Drug Combinations; Drug Interactions; Glucuronides; Humans; Macrocyclic Compounds; Models, Biological; Ritonavir; Sulfonamides; Ticlopidine; Uracil | 2017 |
[Evaluation of PFA P2Y assay in monitoring platelet function in elderly patients with cardiovascular disease receiving clopidogrel treatment].
Topics: Biological Assay; Blood Coagulation Tests; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Sensitivity and Specificity; Ticlopidine | 2016 |
The risk of lower gastrointestinal bleeding in low-dose aspirin users.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Clopidogrel; Comorbidity; Cyclooxygenase 2 Inhibitors; Databases, Factual; Dose-Response Relationship, Drug; Female; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Incidence; Male; Middle Aged; Peptic Ulcer; Peptic Ulcer Hemorrhage; Proton Pump Inhibitors; Renal Insufficiency, Chronic; Risk Factors; Selective Serotonin Reuptake Inhibitors; Taiwan; Ticlopidine; Warfarin; Young Adult | 2017 |
[A Case of Intramural Hematoma of the Esophagus Mimicking Acute Coronary Syndrome].
Topics: Acute Coronary Syndrome; Clopidogrel; Diagnosis, Differential; Endoscopy, Gastrointestinal; Esophageal Diseases; Esophagus; Hematoma; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Tomography, X-Ray Computed | 2017 |
Increased risk of paclitaxel-induced peripheral neuropathy in patients using clopidogrel: a retrospective pilot study.
Topics: Aged; Antineoplastic Agents, Phytogenic; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C8; Female; Humans; Male; Middle Aged; Odds Ratio; Paclitaxel; Peripheral Nervous System Diseases; Pilot Projects; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2017 |
Association of measured platelet reactivity with changes in P2Y
Topics: Aged; Blood Platelets; Brain Ischemia; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2017 |
Balancing the risk of spontaneous ischemic and major bleeding events in acute coronary syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Female; Fibrinolytic Agents; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Risk Factors; Streptokinase; Stroke; Ticagrelor; Ticlopidine; Tissue Plasminogen Activator | 2017 |
Outcome of Triple Antiplatelet Therapy Including Cilostazol in Elderly Patients with ST-Elevation Myocardial Infarction who Underwent Primary Percutaneous Coronary Intervention: Results from the INTERSTELLAR Registry.
Topics: Aged; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Registries; Retrospective Studies; ST Elevation Myocardial Infarction; Tetrazoles; Ticlopidine | 2017 |
Gender-related differences in antiplatelet treatment patterns and outcome: Insights from the GReekAntiPlatElet Registry.
Topics: Acute Coronary Syndrome; Aged; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Female; Greece; Hemorrhage; Humans; Ischemia; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prospective Studies; Registries; Risk Factors; Sex Characteristics; Stents; Ticlopidine; Treatment Outcome | 2017 |
A Multicenter Cohort Comparison Study of the Safety, Efficacy, and Cost of Ticagrelor Compared to Clopidogrel in Aneurysm Flow Diverter Procedures.
Topics: Adenosine; Adolescent; Adult; Aged; Aged, 80 and over; Clopidogrel; Cohort Studies; Drug Costs; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Retrospective Studies; Ticagrelor; Ticlopidine; Treatment Outcome; Young Adult | 2017 |
Effects of ticagrelor on neointimal hyperplasia and endothelial function, compared with clopidogrel and prasugrel, in a porcine coronary stent restenosis model.
Topics: Adenosine; Animals; Clopidogrel; Coronary Restenosis; Drug-Eluting Stents; Endothelium, Vascular; Hyperplasia; Male; Neointima; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Random Allocation; Swine; Ticagrelor; Ticlopidine; Tomography, Optical Coherence; Treatment Outcome | 2017 |
Potentially increased incidence of scaffold thrombosis in patients treated with Absorb BVS who terminated DAPT before 18 months.
Topics: Absorbable Implants; Aged; Aspirin; Cardiovascular Agents; Clopidogrel; Coated Materials, Biocompatible; Coronary Thrombosis; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Incidence; Male; Middle Aged; Netherlands; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prosthesis Design; Registries; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Critical Role of P2Y
Topics: Adenosine; Animals; Autoimmune Diseases; Cell Differentiation; Cells, Cultured; Clopidogrel; Colitis; Diabetes Mellitus, Experimental; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Interleukin-17; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Th17 Cells; Ticagrelor; Ticlopidine; Trinitrobenzenesulfonic Acid | 2017 |
Relationship Between Arterial Access and Outcomes in ST-Elevation Myocardial Infarction With a Pharmacoinvasive Versus Primary Percutaneous Coronary Intervention Strategy: Insights From the STrategic Reperfusion Early After Myocardial Infarction (STREAM)
Topics: Aged; Aspirin; Catheterization, Peripheral; Clopidogrel; Coronary Angiography; Enoxaparin; Female; Femoral Artery; Fibrinolytic Agents; Heart Failure; Hemorrhage; Humans; Male; Middle Aged; Mortality; Multivariate Analysis; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Radial Artery; Recurrence; Shock; ST Elevation Myocardial Infarction; Tenecteplase; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator | 2016 |
Prevalence, Management, and Long-Term (6-Year) Outcomes of Atrial Fibrillation Among Patients Receiving Drug-Eluting Coronary Stents.
Topics: Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Fibrinolytic Agents; Hemorrhage; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prevalence; Proportional Hazards Models; Republic of Korea; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome; Warfarin | 2017 |
Antiplatelet Therapy and Clinical Outcomes Following Myocardial Infarction Among Patients in a U.S. Employer-Based Insurance Database.
Topics: Adolescent; Adult; Aged; Clopidogrel; Databases, Factual; Female; Humans; Male; Medicare; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; United States; Young Adult | 2017 |
Management of Kounis syndrome: two case reports.
Topics: Amoxicillin; Anaphylaxis; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Chest Pain; Clopidogrel; Dexamethasone; Electrocardiography; Guidelines as Topic; Humans; Kounis Syndrome; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2017 |
Clopidogrel Load Reduces Emboli in Carotid Artery Stenosis With Free-Floating Thrombus.
Topics: Carotid Artery, Internal; Carotid Stenosis; Clopidogrel; Embolism; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Tomography Scanners, X-Ray Computed; Ultrasonography, Doppler, Transcranial | 2017 |
Decrease in Switches to 'Unsafe' Proton Pump Inhibitors After Communications About Interactions with Clopidogrel.
Topics: Aged; Clopidogrel; Drug Interactions; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine | 2017 |
Development of Novel High Density Gastroretentive Multiparticulate Pulsatile Tablet of Clopidogrel Bisulfate Using Quality by Design Approach.
Topics: Animals; Clopidogrel; Delayed-Action Preparations; Drug Design; Drug Liberation; Excipients; Gastric Absorption; Gastric Mucosa; Male; Platelet Aggregation Inhibitors; Rabbits; Solubility; Stomach; Tablets; Ticlopidine | 2017 |
Comparison of the Antiplatelet Effects of Once and Twice Daily Low-Dose Ticagrelor and Clopidogrel After Percutaneous Coronary Intervention.
Topics: Adenosine; Aged; Clopidogrel; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Care; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Platelet distribution width as the prognostic marker in coronary bifurcation treatment.
Topics: Aged; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease; Drug-Eluting Stents; Female; Humans; Male; Mean Platelet Volume; Middle Aged; Myocardial Revascularization; Non-ST Elevated Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Recurrence; Ticlopidine; Treatment Outcome | 2017 |
Comparative Effectiveness of Oral Antiplatelet Agents in Patients with Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Adult; Aged; Clopidogrel; Cohort Studies; Databases, Factual; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Period; Prasugrel Hydrochloride; Retrospective Studies; Ticagrelor; Ticlopidine; Treatment Outcome; United States | 2017 |
Impact of mean platelet aggregation degree on long-term clinical outcomes among patients undergoing a complex percutaneous coronary intervention.
Topics: Aged; Aspirin; Chi-Square Distribution; Clopidogrel; Coronary Artery Disease; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Proportional Hazards Models; Risk Factors; Stents; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Novel use of flow diversion for the treatment of aneurysms associated with arteriovenous malformations.
Topics: Adult; Arteriovenous Malformations; Aspirin; Clopidogrel; Embolization, Therapeutic; Female; Humans; Imaging, Three-Dimensional; Intracranial Aneurysm; Magnetic Resonance Angiography; Male; Middle Aged; Stents; Ticlopidine; Tomography Scanners, X-Ray Computed; Treatment Outcome | 2017 |
Platelet Function Testing in Patients with Acute Ischemic Stroke: An Observational Study.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Brain Ischemia; Chi-Square Distribution; Clopidogrel; Cross-Sectional Studies; Cytochrome P-450 CYP2C19; Drug Resistance; Drug Therapy, Combination; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pharmacogenetics; Pharmacogenomic Testing; Pharmacogenomic Variants; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Genetic; Predictive Value of Tests; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2017 |
Use of prasugrel vs clopidogrel and outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention in contemporary clinical practice: Results from the PROMETHEUS study.
Topics: Acute Coronary Syndrome; Aged; Cause of Death; Clopidogrel; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Preoperative Period; Purinergic P2Y Receptor Antagonists; Retrospective Studies; Survival Rate; Ticlopidine; Treatment Outcome | 2017 |
Impact of platelet inhibition level on subsequent no-reflow in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.
Topics: Aged; Area Under Curve; Aspirin; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Angiography; Coronary Circulation; Drug Resistance; Female; Humans; Male; Microcirculation; Middle Aged; Multivariate Analysis; No-Reflow Phenomenon; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Factors; ROC Curve; ST Elevation Myocardial Infarction; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Letter by Moris et al Regarding Article, "Ticagrelor Compared With Clopidogrel in Patients With Prior Lower Extremity Revascularization for Peripheral Artery Disease".
Topics: Clopidogrel; Humans; Lower Extremity; Peripheral Arterial Disease; Ticagrelor; Ticlopidine | 2017 |
Management of diabetic patients hospitalized for acute coronary syndromes: a prospective multicenter registry.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Clopidogrel; Coronary Angiography; Diabetes Mellitus; Disease Management; Female; Hospitalization; Humans; Hyperglycemia; Italy; Male; Middle Aged; Myocardial Revascularization; Percutaneous Coronary Intervention; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Registries; Ticagrelor; Ticlopidine | 2017 |
Ischemic stroke complicating thrombolytic therapy with tenecteplase for ST elevation myocardial infarction: two case reports.
Topics: Aged; Aspirin; Clopidogrel; Electrocardiography; Fibrinolytic Agents; Heparin; Humans; Ischemic Attack, Transient; Male; Middle Aged; Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction; Stents; Stroke; Tenecteplase; Ticlopidine; Tissue Plasminogen Activator; Treatment Outcome | 2017 |
Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma.
Topics: Animals; Cats; Chromatography, High Pressure Liquid; Clopidogrel; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Ticlopidine | 2017 |
The impact of clinical and genetic factors on ticagrelor and clopidogrel antiplatelet therapy.
Topics: Adenosine; Aged; Clopidogrel; Cytochrome P450 Family 4; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenomic Variants; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Time Factors | 2017 |
Preventing graft restenosis after coronary artery bypass grafting with tissue-type plasminogen activator.
Topics: Aged; Aspirin; Blood Coagulation; Clopidogrel; Coronary Angiography; Coronary Artery Bypass; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Prospective Studies; Ticlopidine; Tissue Plasminogen Activator; Treatment Outcome | 2017 |
Quantification of bleeding during dental extraction in patients on dual antiplatelet therapy.
Topics: Aspirin; Blood Loss, Surgical; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Dental Care for Chronically Ill; Female; Hemorrhage; Hemostasis, Surgical; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Ticlopidine; Tooth Extraction | 2017 |
Contemporary use of P2Y12-inhibitors in patients with acute coronary syndrome undergoing percutaneous coronary intervention in Austria: A prospective, multi-centre registry.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aspirin; Austria; Clopidogrel; Female; Hemorrhage; Hospital Mortality; Humans; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prescription Drugs; Prospective Studies; Purinergic P2Y Receptor Antagonists; Registries; Ticagrelor; Ticlopidine | 2017 |
Reversal of the platelet inhibitory effect of the P2Y
Topics: Acute Coronary Syndrome; Adenosine; Blood Platelets; Clopidogrel; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2017 |
Platelet activation by crushed and uncrushed muscle: a flow cytometry analysis.
Topics: Aspirin; Clopidogrel; Flow Cytometry; Humans; Muscle, Skeletal; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine | 2017 |
[[Impact of plestazol preparation on hyperplasia of inter vascular layer in the patients, suffering obliterating atherosclerosis of the lower extremities arteries after reconstructive operations].]
Topics: Aged; Aged, 80 and over; Arteriosclerosis Obliterans; Biomarkers; Case-Control Studies; Cilostazol; Clopidogrel; Endothelium, Vascular; Female; Femoral Artery; Fibroblast Growth Factor 2; Humans; Hyperplasia; Intercellular Adhesion Molecule-1; Lower Extremity; Male; Middle Aged; Plastic Surgery Procedures; Popliteal Artery; Tetrazoles; Ticlopidine; Ultrasonography, Doppler, Duplex; Vasodilator Agents | 2016 |
Do antiplatelet drugs increase the risk of bleeding after tooth extraction? A case-crossover study.
Topics: Aspirin; Cell Adhesion Molecules; Clopidogrel; Cross-Over Studies; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Oral Hemorrhage; Phosphoproteins; Platelet Aggregation Inhibitors; Risk Assessment; Risk Factors; Ticlopidine; Tooth Extraction | 2017 |
APpropriateness Assessment in Antiplatelet THerapY (APATHY) registry: Insight from current clinical practice.
Topics: Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Registries; Retrospective Studies; Ticlopidine | 2017 |
Non-invasive management of post-partum spontaneous left main coronary artery dissection using cardiac computed tomography angiography.
Topics: Adult; Aspirin; Bisoprolol; Cesarean Section; Clopidogrel; Computed Tomography Angiography; Conservative Treatment; Coronary Angiography; Coronary Vessel Anomalies; Diagnosis, Differential; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Postpartum Period; Pregnancy; ST Elevation Myocardial Infarction; Ticlopidine; Treatment Outcome; Troponin T; Vascular Diseases | 2017 |
Comparison of prasugrel versus clopidogrel in Korean patients with acute myocardial infarction undergoing successful revascularization.
Topics: Aged; Asian People; Calcium Channel Blockers; Clopidogrel; Female; Hemorrhage; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2018 |
Clinical determinants of clopidogrel responsiveness in a heterogeneous cohort of Puerto Rican Hispanics.
Topics: Aged; Aged, 80 and over; Blood Platelets; Cardiovascular Diseases; Chi-Square Distribution; Clopidogrel; Cross-Sectional Studies; Drug Resistance; Female; Hispanic or Latino; Humans; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Puerto Rico; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Risk Assessment; Risk Factors; Ticlopidine; Treatment Outcome | 2017 |
Cost-effectiveness analysis of 30-month vs 12-month dual antiplatelet therapy with clopidogrel and aspirin after drug-eluting stents in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Computer Simulation; Coronary Thrombosis; Cost-Benefit Analysis; Decision Trees; Disease-Free Survival; Drug Administration Schedule; Drug Costs; Drug Therapy, Combination; Drug-Eluting Stents; Hemorrhage; Humans; Middle Aged; Models, Economic; Monte Carlo Method; Myocardial Infarction; Odds Ratio; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Intravenous administration of tirofiban versus loading dose of oral clopidogrel for preventing thromboembolism in stent-assisted coiling of intracranial aneurysms.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Clopidogrel; Endovascular Procedures; Female; Fibrinolytic Agents; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Tirofiban; Tyrosine; Young Adult | 2017 |
Repetitive stent thrombosis in a patient with suspected allergy to aspirin and multiple switch between clopidogrel, prasugrel, and ticagrelor.
Topics: Adenosine; Aspirin; Clopidogrel; Coronary Vessels; Drug Hypersensitivity; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Recurrence; Stents; Thrombosis; Ticagrelor; Ticlopidine | 2017 |
Safety and Efficacy of a 600-mg Loading Dose of Clopidogrel 24 Hours Before Pipeline Embolization Device Treatment.
Topics: Clopidogrel; Embolization, Therapeutic; Female; Follow-Up Studies; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Subarachnoid Hemorrhage; Ticlopidine; Treatment Outcome | 2017 |
Aspirin plus clopidogrel was not linked to risk for cancer compared with aspirin alone or no antiplatelets.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Neoplasms; Platelet Aggregation Inhibitors; Ticlopidine | 2017 |
[Carotid Endarterectomy in Patients with Antiaggregation Therapy].
Topics: Aged; Anticoagulants; Carotid Artery Diseases; Clopidogrel; Croatia; Drug Therapy, Combination; Endarterectomy, Carotid; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Ticlopidine; Treatment Outcome | 2016 |
Effect of directly compressible excipient and treated agar on drug release of clopidogrel oral disintegrating tablets.
Topics: Agar; Clopidogrel; Drug Liberation; Excipients; Solubility; Tablets; Ticlopidine | 2017 |
Interaction between platelet-derived microRNAs and CYP2C19*2 genotype on clopidogrel antiplatelet responsiveness in patients with ACS.
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; MicroRNAs; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Ticlopidine | 2017 |
High On-Treatment Platelet Reactivity to Adenosine Diphosphate Predicts Ischemic Events of Minor Stroke and Transient Ischemic Attack.
Topics: Adenosine Diphosphate; Adult; Aged; Aspirin; Blood Platelets; Brain Ischemia; Clopidogrel; Drug Resistance; Drug Therapy, Combination; Female; Humans; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Middle Aged; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Recurrence; Risk Factors; Stroke; Thrombelastography; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Response to: "Aspirin Therapy on Blood Transfusion in Noncardiac Surgery: Evidence From Quality Effect Model".
Topics: Aspirin; Blood Transfusion; Clopidogrel; Platelet Aggregation Inhibitors; Ticlopidine | 2018 |
A retrospective comparison between delayed and early hip fracture surgery in patients taking clopidogrel: same total bleeding but different timing of blood transfusion.
Topics: Aged; Aged, 80 and over; Blood Transfusion; Clopidogrel; Female; Fracture Fixation, Internal; Hemiarthroplasty; Hemorrhage; Hip Fractures; Hip Joint; Hospital Mortality; Humans; Length of Stay; Male; Perioperative Period; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Ticlopidine; Time Factors; Time-to-Treatment; Withholding Treatment | 2017 |
Association of CYP2C19*2 polymorphism with clopidogrel response and 1-year major adverse cardiovascular events in a multiethnic population with drug-eluting stents.
Topics: Alleles; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Risk Factors; Ticlopidine | 2017 |
CYP2C19-guided antiplatelet therapy: a cost-effectiveness analysis of 30-day and 1-year outcomes following percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Drug Costs; Genotype; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2017 |
Stroke of the inferiomedial temporal lobe causing word agnosia.
Topics: Aged; Agnosia; Brain Infarction; Clopidogrel; Humans; Intelligence Tests; Magnetic Resonance Imaging; Male; Perindopril; Simvastatin; Temporal Lobe; Ticlopidine; Treatment Outcome | 2017 |
Evaluation of On-Clopidogrel platelet reactivity overtime, SYNTAX SCORE, genetic polymorphisms and their relationship to one year clinical outcomes in STEMI patients undergoing PCI.
Topics: Adult; Aged; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymerase Chain Reaction; Polymorphism, Genetic; Prospective Studies; Risk Factors; ST Elevation Myocardial Infarction; Ticlopidine; Time Factors | 2018 |
Quantifying Ischemic Risk After Percutaneous Coronary Intervention Attributable to High Platelet Reactivity on Clopidogrel (From the Assessment of Dual Antiplatelet Therapy with Drug-Eluting Stents Study).
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Germany; Graft Occlusion, Vascular; Humans; Incidence; Israel; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Quebec; Registries; Risk Assessment; Risk Factors; Survival Rate; Ticlopidine; United States | 2017 |
Aspirin Versus Clopidogrel for Type 2 Diabetic Patients with First-Ever Noncardioembolic Acute Ischemic Stroke: Ten-Year Survival Data from the Athens Stroke Outcome Project.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Chi-Square Distribution; Clopidogrel; Diabetes Mellitus, Type 2; Female; Greece; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Patient Discharge; Platelet Aggregation Inhibitors; Proportional Hazards Models; Protective Factors; Recurrence; Retrospective Studies; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Association between platelet function and recurrent ischemic vascular events after TIA and minor stroke
.
Topics: Alleles; Aspirin; Blood Coagulation Tests; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Ischemic Attack, Transient; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Recurrence; Stroke; Ticlopidine; Treatment Outcome | 2017 |
Effect of Dialysis on Antiplatelet Drug Efficacy in Uremic Patients with Coronary Heart Disease.
Topics: Aged; Aspirin; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombelastography; Ticlopidine; Uremia | 2017 |
Causes, Timing, and Impact of Dual Antiplatelet Therapy Interruption for Surgery (from the Patterns of Non-adherence to Anti-platelet Regimens In Stented Patients Registry).
Topics: Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Medication Adherence; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Preoperative Care; Prospective Studies; Registries; Retrospective Studies; Ticlopidine; Time Factors; Withholding Treatment | 2017 |
Associations Between Chronic Kidney Disease and Outcomes With Use of Prasugrel Versus Clopidogrel in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Report From the PROMETHEUS Study.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Databases, Factual; Hemorrhage; Humans; Kaplan-Meier Estimate; Kidney; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Propensity Score; Proportional Hazards Models; Renal Insufficiency, Chronic; Risk Factors; Stroke; Ticlopidine; Time Factors; Treatment Outcome; United States | 2017 |
Impact of Aspirin and Clopidogrel Hyporesponsiveness in Patients Treated With Drug-Eluting Stents: 2-Year Results of a Prospective, Multicenter Registry Study.
Topics: Aged; Aspirin; Blood Platelets; Chi-Square Distribution; Clopidogrel; Coronary Thrombosis; Drug Resistance; Drug Therapy, Combination; Drug-Eluting Stents; Female; Germany; Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Proportional Hazards Models; Prospective Studies; Registries; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome; United States | 2017 |
Effects of Dual-Dose Clopidogrel, Clopidogrel Combined with Tongxinluo Capsule, and Ticagrelor on Patients with Coronary Heart Disease and CYP2C19*2 Gene Mutation After Percutaneous Coronary Interventions (PCI).
Topics: Adenosine; Aged; Blood Platelets; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Male; Middle Aged; Mutation; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2017 |
Temporal Trends in the Use of Antiplatelet Therapy in Patients With Acute Coronary Syndromes.
Topics: Acute Coronary Syndrome; Adenosine; Age Factors; Aged; Clopidogrel; Female; Hospitalization; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Practice Patterns, Physicians'; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Registries; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine | 2018 |
The effect of CYP2C19 genetic polymorphism and non-genetic factors on clopidogrel platelets inhibition in East Asian coronary artery disease patients.
Topics: Asian People; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Female; Humans; Male; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine | 2017 |
The impact of CYP2C19*2, CYP4F2*3, and clinical factors on platelet aggregation, CYP4F2 enzyme activity, and 20-hydroxyeicosatetraenoic acid concentration in patients treated with dual antiplatelet therapy.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P450 Family 4; Female; Humans; Hydroxyeicosatetraenoic Acids; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2017 |
Platelet transfusion to reverse antiplatelet therapy before decompressive surgery in patients with intracranial haemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Decompression, Surgical; Female; Hemorrhage; Humans; Intracranial Hemorrhages; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Preoperative Care; Stroke; Thrombosis; Ticlopidine | 2017 |
Point-Counterpoint: CYP2C19 Genotyping for Clopidogrel.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Pharmacogenomic Testing; Platelet Aggregation Inhibitors; Ticlopidine | 2017 |
[Dual Antiplatelet Therapy in the Perioperative Period - To Continue or Discontinue Treatment?]
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Perioperative Period; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticlopidine | 2017 |
Aspirin Therapy on Blood Transfusion in Noncardiac Surgery: Evidence From Quality Effect Model.
Topics: Aspirin; Blood Transfusion; Clopidogrel; Platelet Aggregation Inhibitors; Ticlopidine | 2018 |
Effects With and Without Clopidogrel Loading Treatment for Acute Ischemic Cerebrovascular Disease Patients: A Retrospective Cohort Study.
Topics: Aged; Aged, 80 and over; Brain; Brain Ischemia; Clinical Decision-Making; Clopidogrel; Disease Progression; Female; Humans; Japan; Logistic Models; Male; Middle Aged; Multivariate Analysis; Nerve Degeneration; Neuroprotective Agents; Odds Ratio; Patient Selection; Platelet Aggregation Inhibitors; Propensity Score; Retrospective Studies; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Emergent loading dose of antiplatelets for stenting after IV rt-PA in acute ischemic stroke: a feasibility study.
Topics: Administration, Intravenous; Aged; Aspirin; Brain Ischemia; Clopidogrel; Computed Tomography Angiography; Feasibility Studies; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Severity of Illness Index; Stents; Stroke; Ticlopidine; Tissue Plasminogen Activator; Tomography Scanners, X-Ray Computed; Treatment Outcome | 2018 |
Contemporary Time Trends in Use of Antiplatelet Agents Among Patients with Acute Coronary Syndrome and Comorbid Diabetes Mellitus or Chronic Kidney Disease.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Cohort Studies; Diabetes Mellitus; Drug Utilization Review; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Renal Insufficiency, Chronic; Ticagrelor; Ticlopidine | 2017 |
Antiplatelet treatment in diabetic patients with acute coronary syndrome undergoing percutaneous coronary intervention: a GReek AntiPlatElet registry substudy.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Case-Control Studies; Clopidogrel; Cohort Studies; Comorbidity; Diabetes Mellitus; Female; Greece; Hemorrhage; Humans; Male; Middle Aged; Mortality; Myocardial Infarction; Myocardial Revascularization; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Propensity Score; Proportional Hazards Models; Prospective Studies; Stroke; Ticagrelor; Ticlopidine | 2018 |
High risk of stent thrombosis in the first 6 months after coronary stenting: Do not discontinue clopidogrel early after ACS.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Drug Administration Schedule; Female; Graft Occlusion, Vascular; Humans; Incidence; Male; Middle Aged; Netherlands; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Registries; Risk Factors; Stents; Ticlopidine | 2017 |
Too Hot? Too Cold? When Is it "Just Right" to Stop Dual Antiplatelet Therapy After PCI With DES?
Topics: Aspirin; Clopidogrel; Data Analysis; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2017 |
A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms.
Topics: Adult; Aged; Aged, 80 and over; Aminobutyrates; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Carboxylic Ester Hydrolases; Cell Line; Clopidogrel; Drug Combinations; Enalapril; Female; Gene Frequency; Genetic Variation; Haplotypes; Humans; Liver; Loss of Function Mutation; Male; Middle Aged; Polymorphism, Single Nucleotide; RNA, Messenger; Sequence Analysis, DNA; Tetrazoles; Ticlopidine; Valsartan; Young Adult | 2017 |
Clopidogrel IBS Patients Have Higher Incidence of Gastrointestinal Symptoms Influenced by Age and Gender.
Topics: Abdominal Pain; Adolescent; Adult; Age Factors; Aged; Clopidogrel; Constipation; Databases, Factual; Diarrhea; Electronic Health Records; Enteric Nervous System; Female; Flatulence; Gastroparesis; Humans; Incidence; Intestines; Irritable Bowel Syndrome; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Retrospective Studies; Risk Factors; Sex Factors; Ticlopidine; Time Factors; Young Adult | 2017 |
Effects of statin therapy on platelet reactivity after percutaneous coronary revascularization in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Middle Aged; Percutaneous Coronary Intervention; Platelet Activation; Ticlopidine | 2017 |
Changes in Treatment Patterns and Incremental Health Care Utilization Due to P2Y12-Associated Complications in Patients with Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Middle Aged; Patient Acceptance of Health Care; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Retrospective Studies; Secondary Prevention; Ticagrelor; Ticlopidine | 2017 |
Contemporary antiplatelet therapy in acute coronary syndromes: are there differences in outcomes and discontinuation between clopidogrel and ticagrelor?
Topics: Acute Coronary Syndrome; Adenosine; Aged; Clopidogrel; Cohort Studies; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome; Withholding Treatment | 2017 |
Recurrent Cardiovascular Events Despite Antiplatelet Therapy in a Patient with Polycythemia Vera and Accelerated Platelet Turnover.
Topics: Adenosine; Brain Infarction; Clopidogrel; Drug Therapy, Combination; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polycythemia Vera; Purinergic P2Y Receptor Antagonists; Secondary Prevention; Thrombocytosis; Ticagrelor; Ticlopidine | 2017 |
Which is the best antiaggregant or anticoagulant therapy after TAVI? A propensity-matched analysis from the ITER registry. The management of DAPT after TAVI.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cohort Studies; Female; Hemorrhage; Humans; Male; Platelet Aggregation Inhibitors; Propensity Score; Registries; Stroke; Ticlopidine; Transcatheter Aortic Valve Replacement | 2017 |
A Decision Instrument to Identify Isolated Traumatic Subdural Hematomas at Low Risk of Neurologic Deterioration, Surgical Intervention, or Radiographic Worsening.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Clopidogrel; Cohort Studies; Decision Support Techniques; Emergency Service, Hospital; Female; Glasgow Coma Scale; Hematoma, Subdural; Humans; Likelihood Functions; Male; Middle Aged; Neuroimaging; Neurosurgical Procedures; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Ticlopidine; Warfarin; Young Adult | 2017 |
Topics: Biomarkers; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Magnetic Resonance Spectroscopy; Ticlopidine | 2017 |
Safety and efficacy of prasugrel in East Asian patients with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2018 |
Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite.
Topics: Adult; Aged; Clopidogrel; Female; Genotype; Humans; Male; Models, Theoretical; Platelet Aggregation Inhibitors; Sulfhydryl Compounds; Ticlopidine | 2017 |
The efficacy and safety of cilostazol as an alternative to aspirin in Chinese patients with aspirin intolerance after coronary stent implantation: a combined clinical study and computational system pharmacology analysis.
Topics: Aged; Asian People; Aspirin; China; Cilostazol; Clopidogrel; Coronary Restenosis; Data Interpretation, Statistical; Drug Combinations; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Molecular Docking Simulation; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Tetrazoles; Ticlopidine | 2018 |
Safety and Necessity of Antiplatelet Therapy on Patients Underwent Endovascular Aortic Repair with Both Stanford Type B Aortic Dissection and Coronary Heart Disease.
Topics: Adult; Aged; Aspirin; Clopidogrel; Coronary Angiography; Coronary Disease; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2017 |
Intramuscular hematoma with motor weakness after trigger point injection: A case report.
Topics: Aged; Biopsy, Fine-Needle; Buttocks; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Female; Glucocorticoids; Hematoma; Humans; Image-Guided Biopsy; Injections, Epidural; Low Back Pain; Muscle Weakness; Muscle, Skeletal; Platelet Aggregation Inhibitors; Spinal Stenosis; Ticlopidine; Treatment Outcome; Trigger Points; Ultrasonography | 2017 |
Poor prognosis after surgery for intertrochanteric fracture in elderly patients with clopidogrel treatment: A cohort study.
Topics: Aged; Blood Loss, Surgical; Blood Transfusion; Cardiovascular Diseases; China; Clopidogrel; Cohort Studies; Female; Fracture Fixation, Intramedullary; Hip Fractures; Humans; Intraoperative Complications; Length of Stay; Male; Operative Time; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Ticlopidine; Treatment Outcome | 2017 |
Impact of Double Loading Regimen of Clopidogrel on Final Angiographic Results, Incidence of Upper Gastrointestinal Bleeding and Clinical Outcomes in Patients with STEMI Undergoing Primary Coronary Intervention.
Topics: Clopidogrel; Coronary Angiography; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Graft Occlusion, Vascular; Humans; Incidence; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; ST Elevation Myocardial Infarction; Survival Rate; Taiwan; Thrombolytic Therapy; Ticlopidine; Time Factors | 2017 |
In PCI-treated ACS, switching from aspirin + a newer P2Y12 blocker to aspirin + clopidogrel reduced adverse events.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2017 |
Risky business? Investigating outcomes of patients undergoing urgent laparoscopic appendectomy on antithrombotic therapy.
Topics: Adult; Appendectomy; Appendicitis; Aspirin; Blood Loss, Surgical; Blood Transfusion; Clopidogrel; Female; Fibrinolytic Agents; Humans; Laparoscopy; Length of Stay; Male; Middle Aged; Patient Readmission; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Surgical Wound Infection; Ticlopidine; Treatment Outcome; United States | 2017 |
Superior safety of dual therapy with dabigatran and clopidogrel vs. triple therapy with warfarin, aspirin and clopidogrel in the RE-DUAL PCI trial: What is key, the strategy or the drug?
Topics: Aspirin; Clopidogrel; Dabigatran; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Warfarin | 2017 |
Perioperative Outcomes of Patients Undergoing Lobectomy on Clopidogrel.
Topics: Aged; Aged, 80 and over; Clopidogrel; Databases, Factual; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Middle Aged; Platelet Aggregation Inhibitors; Pneumonectomy; Postoperative Complications; Retrospective Studies; Ticlopidine; Treatment Outcome | 2017 |
Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects.
Topics: Biopsy; Carboxylic Ester Hydrolases; Clopidogrel; Cohort Studies; DNA Mutational Analysis; Dose-Response Relationship, Drug; Female; Finland; Gastric Bypass; Gene Expression Regulation, Enzymologic; Humans; Hydrolysis; Introns; Liver; Male; Mutation, Missense; Pharmacogenomic Variants; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Reproducibility of Results; RNA, Messenger; Ticlopidine | 2018 |
Comparison of 4 different strategies of DAPT after PCI in ACS real world population from a Northern Italy registry.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Italy; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Care; Prasugrel Hydrochloride; Registries; Retrospective Studies; Ticagrelor; Ticlopidine | 2017 |
Scorpion bite-induced ischaemic stroke.
Topics: Animals; Biomarkers; Catecholamines; Cerebral Angiography; Clopidogrel; Fatal Outcome; Female; Heart Arrest; Humans; Infarction, Middle Cerebral Artery; Magnetic Resonance Angiography; Middle Aged; Platelet Aggregation Inhibitors; Scorpion Stings; Scorpions; Stroke; Thrombolytic Therapy; Ticlopidine | 2017 |
Isolated left ventricular non-compaction (LVNC) and recurrent strokes: to anticoagulate or not to anticoagulate, that is the question.
Topics: Aged; Anticoagulants; Aspirin; Clopidogrel; Diagnosis, Differential; Humans; Isolated Noncompaction of the Ventricular Myocardium; Magnetic Resonance Imaging; Male; Recurrence; Stroke; Ticlopidine | 2017 |
Outcome of Transurethral Resection of Bladder Tumor: Does Antiplatelet Therapy Really Matter? Analysis of a Retrospective Series.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Loss, Surgical; Carcinoma, Transitional Cell; Clopidogrel; Cystoscopy; Female; Hemorrhage; Humans; Intraoperative Complications; Length of Stay; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine; Urinary Bladder Neoplasms; Urologic Surgical Procedures | 2017 |
Impaired liver cytochrome P450 2C11 activity after dual antiplatelet therapy with aspirin and clopidogrel in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Aspirin; Chromatography, Liquid; Clopidogrel; Cytochrome P450 Family 2; Inactivation, Metabolic; Liver; Male; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Salicylic Acid; Steroid 16-alpha-Hydroxylase; Tandem Mass Spectrometry; Ticlopidine | 2018 |
A pharmacokinetic model of drug-drug interaction between clopidogrel and omeprazole at CYP2C19 in humans.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Omeprazole; Ticlopidine | 2017 |
Contemporary use of P2Y
Topics: Adenosine; Adult; Aged; Clopidogrel; Humans; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Poland; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Registries; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine | 2018 |
Raman chemical imaging for spectroscopic screening and direct quantification of falsified drugs.
Topics: Calibration; Clopidogrel; Counterfeit Drugs; Least-Squares Analysis; Microscopy; Multivariate Analysis; Sildenafil Citrate; Spectrum Analysis, Raman; Tablets; Ticlopidine | 2018 |
Real-world clopidogrel utilization in acute coronary syndromes: patients selection and outcomes in a single-center experience.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Chi-Square Distribution; Clopidogrel; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization Review; Female; Hemorrhage; Hospital Mortality; Humans; Italy; Logistic Models; Male; Middle Aged; Multivariate Analysis; Non-ST Elevated Myocardial Infarction; Patient Selection; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Risk Factors; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome | 2017 |
Portal vein thrombosis before and after transjugular intrahepatic portosystemic shunt placement: An observational study (STROBE compliant).
Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Aspirin; Clopidogrel; Female; Humans; Leukocyte Count; Liver Cirrhosis; Male; Middle Aged; Portal Vein; Portasystemic Shunt, Transjugular Intrahepatic; Prospective Studies; Risk Factors; Severity of Illness Index; Ticlopidine; Venous Thrombosis; Warfarin | 2017 |
Clopidogrel or ticagrelor in acute coronary syndrome patients treated with newer-generation drug-eluting stents: CHANGE DAPT.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Aged, 80 and over; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2017 |
Decreased platelet inhibition by P2Y12 receptor blockers in anaemia.
Topics: Adenosine; Adenosine Diphosphate; Aged; Anemia; Angioplasty; Aspirin; Clopidogrel; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Monocytes; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Ticagrelor; Ticlopidine | 2018 |
17β-estradiol suppresses carboxylesterases by activating c-Jun/AP-1 pathway in primary human and mouse hepatocytes.
Topics: Animals; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Clopidogrel; Enzyme Inhibitors; Estradiol; Female; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Hydrolysis; Irinotecan; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred ICR; Receptors, Estrogen; Ticlopidine; Transcription Factor AP-1; Transcription, Genetic | 2018 |
Clinical characteristics and outcomes of patients with coronary artery spasm who initially presented with acute myocardial infarction.
Topics: Adult; Aged; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Coronary Vasospasm; Female; Follow-Up Studies; Humans; Incidence; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; Propensity Score; Proportional Hazards Models; Recurrence; Retrospective Studies; Ticlopidine | 2018 |
[Influence of CYP2C19 gene polymorphisms on the efficacy of clopidogrel treatment for the prevention of ischemic stroke following coronary stent implantation].
Topics: Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stents; Stroke; Ticlopidine | 2017 |
Development of a high-performance liquid chromatography method for the simultaneous determination of chiral impurities and assay of (S)-clopidogrel using a cellulose-based chiral stationary phase in methanol/water mode.
Topics: Cellulose; Chromatography, High Pressure Liquid; Clopidogrel; Methanol; Molecular Structure; Stereoisomerism; Ticlopidine; Water | 2018 |
Cost-effectiveness of prasugrel versus clopidogrel in acute coronary syndrome patients undergoing percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Clopidogrel; Cost-Benefit Analysis; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2018 |
Prasugrel vs clopidogrel in contemporary Western European patients with acute coronary syndromes receiving drug-eluting stents: Comparative cost-effectiveness analysis from the BASKET-PROVE cohorts - Response to the letter to the Editor.
Topics: Acute Coronary Syndrome; Clopidogrel; Cost-Benefit Analysis; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2018 |
Cigarette smoking reduces platelet reactivity independently of clopidogrel treatment in patients with non-ST elevation acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Biomarkers; Blood Platelets; Cigarette Smoking; Clopidogrel; Comorbidity; Electrocardiography; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2018 |
Clopidogrel in a combined therapy with anticancer drugs-effect on tumor growth, metastasis, and treatment toxicity: Studies in animal models.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Clopidogrel; Fluorouracil; Humans; Male; Mice; Neoplasms, Experimental; Platelet Aggregation Inhibitors; Prostatic Neoplasms; Ticlopidine | 2017 |
Risk factors for postpolypectomy bleeding in patients receiving anticoagulation or antiplatelet medications.
Topics: Aged; Anticoagulants; Aspirin; Case-Control Studies; Clopidogrel; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Female; Gastrointestinal Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Incidence; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Retrospective Studies; Risk Factors; Thromboembolism; Ticlopidine; Time Factors; Warfarin | 2018 |
Unplanned readmission following transoral robotic surgery.
Topics: Carcinoma, Squamous Cell; Clopidogrel; Dehydration; Female; Humans; Male; Middle Aged; Mouth; Mouth Neoplasms; Oral Hemorrhage; Pain, Postoperative; Patient Readmission; Platelet Aggregation Inhibitors; Postoperative Complications; Retrospective Studies; Risk Factors; Robotic Surgical Procedures; Ticlopidine | 2017 |
Impact of Proton-pump Inhibitors on the Pharmacodynamic Effect and Clinical Outcomes in Patients Receiving Dual Antiplatelet Therapy after Percutaneous Coronary Intervention: A Propensity Score Analysis.
Topics: Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Thrombelastography; Ticlopidine | 2017 |
Effect of cytochrome P450 2C19 polymorphism on adverse cardiovascular events after drug-eluting stent implantation in a large Hakka population with acute coronary syndrome receiving clopidogrel in southern China.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Asian People; Chi-Square Distribution; China; Clinical Decision-Making; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Female; Gene Frequency; Genetic Predisposition to Disease; Hemorrhage; Heterozygote; Homozygote; Humans; Hypertension; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Precision Medicine; Retrospective Studies; Risk Factors; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2018 |
Comparison of Single Nucleotide Polymorphism genotyping of CYP2C19 by Loop-mediated isothermal amplification and real-time PCR melting curve analysis.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Genotyping Techniques; Humans; Nucleic Acid Amplification Techniques; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Ticlopidine; Transition Temperature | 2018 |
Analysis of the CYP2C19 genotype associated with bleeding in Serbian STEMI patients who have undergone primary PCI and treatment with clopidogrel.
Topics: Aged; Chi-Square Distribution; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genetic Predisposition to Disease; Haplotypes; Hemorrhage; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Percutaneous Coronary Intervention; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Retrospective Studies; Risk Factors; Serbia; ST Elevation Myocardial Infarction; Ticlopidine; Treatment Outcome | 2018 |
Comparison of Two Point-of-Care
Topics: Biological Assay; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Genotyping Techniques; Humans; Nanospheres; Nucleic Acids; Phenotype; Platelet Aggregation Inhibitors; Point-of-Care Systems; Ticlopidine | 2017 |
What is the significance, if any, of the increased incidence of stent thrombosis with dual therapy of dabigatran 110mg twice daily and clopidogrel in the RE-DUAL PCI trial?
Topics: Clopidogrel; Dabigatran; Drug Therapy, Combination; Humans; Incidence; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine; Treatment Outcome | 2018 |
Dual Antiplatelet Therapy Guided by CYP2C19 Polymorphisms after Implantation of Second-Generation Drug-Eluting Stents for Management of Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Cytochrome P-450 CYP2C19; DNA; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Incidence; Japan; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Postoperative Complications; Prasugrel Hydrochloride; Retrospective Studies; Stroke; Ticlopidine | 2018 |
STARTING-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Intravenous Thrombolysis for Stroke.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Hemorrhage; Clopidogrel; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Nomograms; Risk Factors; Stroke; Thrombolytic Therapy; Ticlopidine; Tissue Plasminogen Activator | 2018 |
Etiology of gastrointestinal bleeding in patients on dual antiplatelet therapy.
Topics: Aged; Aspirin; Clopidogrel; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Female; Gastroenteritis; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Risk Factors; Severity of Illness Index; Ticlopidine | 2018 |
Subacute cutaneous lupus erythematosus: is clopidogrel a trigger?
Topics: Aged; Clopidogrel; Humans; Lupus Erythematosus, Cutaneous; Male; Platelet Aggregation Inhibitors; Skin; Ticlopidine | 2018 |
A synergic effect between CYP2C19*2, CYP2C19*3 loss-of-function and CYP2C19*17 gain-of-function alleles is associated with Clopidogrel resistance among Moroccan Acute Coronary Syndromes patients.
Topics: Acute Coronary Syndrome; Aged; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Gene Frequency; Genetic Variation; Genotype; Humans; Male; Middle Aged; Morocco; Platelet Aggregation Inhibitors; Ticlopidine | 2018 |
A Rare Case Series of Ischemic Stroke Following Russell's Viper Snake Bite in India.
Topics: Aged; Animals; Antivenins; Cerebral Infarction; Clopidogrel; Daboia; Humans; India; Male; Middle Aged; Platelet Aggregation Inhibitors; Snake Bites; Ticlopidine; Tomography, X-Ray Computed; Viper Venoms | 2017 |
Time trends in peripheral artery disease incidence, prevalence and secondary preventive therapy: a cohort study in The Health Improvement Network in the UK.
Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Clopidogrel; Female; Forecasting; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Middle Aged; Peripheral Arterial Disease; Retrospective Studies; Risk Factors; Secondary Prevention; Ticlopidine; United Kingdom | 2018 |
Which Antiplatelet Therapy in Patients With Left Ventricular Assist Device and Aspirin Allergy?
Topics: Aspirin; Clopidogrel; Drug Hypersensitivity; Drug Therapy, Combination; Heart Failure; Heart-Assist Devices; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Complications; Thrombosis; Ticlopidine; Warfarin | 2018 |
WATCHMAN device-related thrombus successfully treated with apixaban: A case report.
Topics: Aged; Anticoagulants; Aspirin; Atrial Appendage; Atrial Fibrillation; Clopidogrel; Factor Xa Inhibitors; Humans; Male; Prostheses and Implants; Pyrazoles; Pyridones; Thrombosis; Ticlopidine | 2017 |
Acute stent thrombosis after stent-assisted coiling in an intracranial aneurysm patient carrying two reduced-function CYP2C19 alleles: A case report.
Topics: Adult; Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Intracranial Aneurysm; Male; Pharmacogenomic Variants; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2017 |
An Evaluation of the Cost-effectiveness of Comprehensive MTM Integrated with Point-of-Care Phenotypic and Genetic Testing for U.S. Elderly Patients After Percutaneous Coronary Intervention.
Topics: Acute Coronary Syndrome; Adenosine; Age Factors; Aged; Clopidogrel; Community Pharmacy Services; Computer Simulation; Cost-Benefit Analysis; Decision Trees; Delivery of Health Care, Integrated; Drug Costs; Female; Genetic Testing; Humans; Male; Markov Chains; Medication Therapy Management; Models, Economic; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Point-of-Care Testing; Precision Medicine; Predictive Value of Tests; Program Evaluation; Quality of Life; Quality-Adjusted Life Years; Ticagrelor; Ticlopidine; Time Factors; Treatment Outcome; United States | 2018 |
Effect of Antiplatelet Therapy on Cardiac Outcomes in Patients With Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Out-of-Hospital Cardiac Arrest; Platelet Aggregation Inhibitors; Ticlopidine | 2018 |
CYP2C19 and ABCB1 genetic polymorphisms correlate with the recurrence of ischemic cardiovascular adverse events after clopidogrel treatment.
Topics: Aged; Analysis of Variance; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; DNA Mutational Analysis; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Recurrence; Retrospective Studies; Ticlopidine | 2018 |
Antiplatelet Therapy in ACS Patients: Comparing Appropriate P2Y12 Inhibition by Clopidogrel to the Use of New P2Y12 Inhibitors.
Topics: Acute Coronary Syndrome; Adenosine; Adult; Aged; Aged, 80 and over; Clopidogrel; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prognosis; Prospective Studies; Receptors, Purinergic P2Y12; Ticagrelor; Ticlopidine | 2018 |
A Difference in Bleeding and Use of Blood and Blood Products in Patients who Were Preoperatively on Aspirin or Dual Antiplatelet Therapy Before Coronary Artery Bypass Grafting.
Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Preoperative Care; Retrospective Studies; Ticlopidine | 2018 |
Defining a Clopidogrel Response Cut-Off Value Using Light Transmission Aggregometry Before Pipeline Embolization of Unruptured Intracranial Aneurysms.
Topics: Adult; Aged; Aged, 80 and over; Clopidogrel; Databases, Factual; Dose-Response Relationship, Drug; Embolization, Therapeutic; Female; Humans; Intracranial Aneurysm; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Retrospective Studies; Risk; Stents; Thromboembolism; Thrombophilia; Ticlopidine; Treatment Outcome | 2018 |
Basilar artery fenestration: an unusual possible cause of ischaemic stroke?
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ataxia; Basilar Artery; Cerebral Angiography; Clopidogrel; Humans; Magnetic Resonance Imaging; Male; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Treatment Outcome; Vertebrobasilar Insufficiency; Vertigo; Vomiting | 2018 |
Assessment of the potential drug-drug interaction between carvedilol and clopidogrel mediated through intestinal P-glycoprotein.
Topics: Adrenergic beta-Antagonists; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbazoles; Carvedilol; Clopidogrel; Drug Interactions; Intestinal Absorption; Intestine, Small; Male; Metoprolol; Perfusion; Permeability; Platelet Aggregation Inhibitors; Propanolamines; Rats; Rats, Wistar; Ticlopidine; Verapamil | 2016 |
Reversal of antiplatelet therapy in traumatic intracranial hemorrhage: Does timing matter?
Topics: Adult; Aged; Aspirin; Clopidogrel; Female; Glasgow Coma Scale; Hematoma, Subdural; Humans; Intracranial Hemorrhage, Traumatic; Middle Aged; Platelet Aggregation Inhibitors; Platelet Transfusion; Retrospective Studies; Risk Factors; Ticlopidine; Time Factors | 2018 |
Self-Reported Headaches in Patients with Unruptured Intracranial Aneurysms Treated with the Pipeline Embolization Device.
Topics: Adult; Aged; Aged, 80 and over; Angiography, Digital Subtraction; Aspirin; Clopidogrel; Comorbidity; Embolization, Therapeutic; Female; Headache Disorders, Secondary; Humans; Intracranial Aneurysm; Magnetic Resonance Angiography; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Self Report; Single-Blind Method; Surveys and Questionnaires; Ticlopidine; Treatment Outcome | 2018 |
The Prognostic Value of Combinations of Genetic Polymorphisms in the ITGB3, ITGA2, and CYP2C19*2 Genes in Predicting Cardiovascular Outcomes After Coronary Bypass Grafting.
Topics: Aged; Alleles; Angina Pectoris; Aspirin; Clopidogrel; Combined Modality Therapy; Coronary Artery Bypass; Cytochrome P-450 CYP2C19; Humans; Integrin alpha2; Integrin beta3; Middle Aged; Mutation; Platelet Aggregation; Polymorphism, Single Nucleotide; Prognosis; Real-Time Polymerase Chain Reaction; Ticlopidine; Treatment Outcome | 2018 |
CHARACTERIZATION OF BINDING SITES OF CLOPIDOGREL AND INTERFERENCE OF LINOLEIC ACID AT THE BINDING SITE ON BOVINE SERUM ALBUMIN.
Topics: Binding Sites; Clopidogrel; Linoleic Acid; Serum Albumin, Bovine; Ticlopidine | 2017 |
Associations Between Complex PCI and Prasugrel or Clopidogrel Use in Patients With Acute Coronary Syndrome Who Undergo PCI: From the PROMETHEUS Study.
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Clopidogrel; Cohort Studies; Combined Modality Therapy; Coronary Thrombosis; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Severity of Illness Index; Survival Analysis; Ticlopidine; Treatment Outcome; United States | 2018 |
Gene polymorphisms in dual antiplatelet therapy and the presence of hypo-attenuated leaflet thickening after transcatheter aortic valve replacement.
Topics: Aged; Aged, 80 and over; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Female; Heart Valve Prosthesis; Humans; Male; Pilot Projects; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Prospective Studies; Ticlopidine; Transcatheter Aortic Valve Replacement | 2018 |
Effects of Danshen capsules on the pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.
Topics: Abietanes; Area Under Curve; Blotting, Western; Chromatography, High Pressure Liquid; Clopidogrel; Cytochrome P-450 CYP3A; Enzyme Induction; Healthy Volunteers; Hep G2 Cells; Hepatocytes; Humans; Male; Phenanthrenes; Platelet Aggregation Inhibitors; Salvia miltiorrhiza; Tandem Mass Spectrometry; Ticlopidine | 2018 |
Enzyme Kinetics and Molecular Docking Studies on Cytochrome 2B6, 2C19, 2E1, and 3A4 Activities by Sauchinone.
Topics: Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Benzopyrans; Binding Sites; Catalytic Domain; Chlorzoxazone; Clopidogrel; Cyclobutanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dioxoles; Herb-Drug Interactions; Humans; Hypoglycemic Agents; Kinetics; Mice; Microsomes, Liver; Molecular Docking Simulation; Plant Components, Aerial; Plant Extracts; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Saururaceae; Ticlopidine | 2018 |
Perioperative Use of Anticoagulant and Platelet-inhibiting Medications for Elective Spine Surgery: Results of a Nationwide Survey.
Topics: Anticoagulants; Clopidogrel; Elective Surgical Procedures; Fibrinolytic Agents; Health Care Surveys; Hemorrhage; Heparin; Humans; Neurosurgical Procedures; Orthopedic Procedures; Platelet Aggregation Inhibitors; Spine; Ticlopidine | 2018 |
Pharmacometabolomics analysis of plasma to phenotype clopidogrel high on treatment platelets reactivity in coronary artery disease patients.
Topics: Aged; Biomarkers; Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Monitoring; Drug Resistance; Female; Genotype; Humans; Male; Metabolomics; Middle Aged; Percutaneous Coronary Intervention; Pharmacogenomic Variants; Phenotype; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Proton Magnetic Resonance Spectroscopy; Risk Factors; Ticlopidine; Time Factors; Treatment Outcome | 2018 |
[Temporal evolution of antithrombotic therapy use in patients with acute coronary syndromes undergoing percutaneous coronary intervention in Italy: comparison between the EYESHOT and SCOPE registries].
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Fibrinolytic Agents; Humans; Italy; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine | 2018 |
Nonsteroidal anti-inflammatory drug choice and adverse outcomes in clopidogrel users: A retrospective cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Clopidogrel; Drug Interactions; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Incidence; Intracranial Hemorrhages; Medicaid; Middle Aged; Mortality; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Ticlopidine; United States; Young Adult | 2018 |
Compression force sensing regulates integrin α
Topics: Adult; Animals; Aspirin; Blood Platelets; Clopidogrel; Diabetes Mellitus, Type 1; Female; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Phosphatidylinositol 3-Kinases; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Thrombosis; Ticlopidine | 2018 |
Panax quinquefolius saponins combined with dual antiplatelet drug therapy alleviate gastric mucosal injury and thrombogenesis through the COX/PG pathway in a rat model of acute myocardial infarction.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Blood Platelets; Clopidogrel; Cyclooxygenase 2; Gastric Mucosa; Male; Myocardial Infarction; Myocardium; Panax; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Saponins; Thromboxane B2; Ticlopidine; Tissue Plasminogen Activator; Vascular Endothelial Growth Factor A | 2018 |
Artery of Percheron: an unusual stroke presentation.
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Atorvastatin; Cerebral Arteries; Clopidogrel; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Stroke; Ticlopidine; Vascular Malformations | 2018 |
Single and dual antiplatelet therapy in elderly patients of medically managed myocardial infarction.
Topics: Aged, 80 and over; Aspirin; Cause of Death; Clopidogrel; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; ST Elevation Myocardial Infarction; Taiwan; Ticlopidine; Time Factors; Treatment Outcome | 2018 |
DEVELOPMENT OF COMPRESSED COATED POLYPILL WITH MUCOADHESIVE CORE COMPRISING OF ATORVASTATIN/CLOPIDOGREL/ASPIRIN USING COMPRESSION COATING TECHNIQUE.
Topics: Acrylates; Adhesiveness; Administration, Oral; Animals; Aspirin; Atorvastatin; Carboxymethylcellulose Sodium; Chemistry, Pharmaceutical; Clopidogrel; Delayed-Action Preparations; Drug Combinations; Drug Compounding; Drug Liberation; Hydrogen-Ion Concentration; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypromellose Derivatives; Intestinal Mucosa; Kinetics; Models, Chemical; Platelet Aggregation Inhibitors; Polymers; Polypharmacy; Rabbits; Solubility; Surface Properties; Tablets, Enteric-Coated; Technology, Pharmaceutical; Ticlopidine | 2017 |
Acute myocardial infarction occurring while on chronic clopidogrel therapy ('clopidogrel failure') is associated with high incidence of clopidogrel poor responsiveness and stent thrombosis.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Thrombosis; Ticlopidine; Treatment Failure | 2018 |
Do practice gaps exist in evidence-based medication prescription at hospital discharge in patients undergoing coronary artery bypass surgery & coronary angioplasty?
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angioplasty; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Coronary Artery Bypass; Coronary Artery Disease; Coronary Vessels; Drug Prescriptions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; India; Male; Middle Aged; Percutaneous Coronary Intervention; Professional Practice Gaps; Retrospective Studies; Ticlopidine | 2017 |
Clinical outcomes of potent antiplatelets compared with clopidogrel in ST elevation myocardial infarction.
Topics: Clopidogrel; Humans; Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction; Ticlopidine | 2018 |
Review: Adding clopidogrel to ASA reduces CV morbidity but increases bleeding in patients at high risk for CV events.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2018 |
Detection of individual responses to clopidogrel: Validation of a novel, rapid analysis using thrombelastography 6s.
Topics: Acute Coronary Syndrome; Adolescent; Adult; Aged; Area Under Curve; Case-Control Studies; Clopidogrel; Drug Monitoring; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Predictive Value of Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Reproducibility of Results; ROC Curve; Thrombelastography; Ticlopidine; Time Factors; Whole Blood Coagulation Time; Young Adult | 2018 |
Synthesis of a Novel Series of Amino Acid Prodrugs Based on Thienopyridine Scaffolds and Evaluation of Their Antiplatelet Activity.
Topics: Adenosine Diphosphate; Animals; Bleeding Time; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Molecular Structure; Platelet Aggregation; Prasugrel Hydrochloride; Prodrugs; Rats; Thienopyridines; Ticlopidine | 2018 |
Health Economic Analysis of Antiplatelet Therapy for Acute Coronary Syndromes in the Context of Five Eastern Asian Countries.
Topics: Acute Coronary Syndrome; Adenosine; Aged; Asia; China; Clinical Trials as Topic; Clopidogrel; Cost-Benefit Analysis; Decision Trees; Female; Health Care Costs; Hong Kong; Humans; Japan; Male; Middle Aged; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Republic of Korea; Taiwan; Ticagrelor; Ticlopidine | 2018 |
Anterior spinal cord infarct: a rare yet disabling stroke.
Topics: Aged, 80 and over; Aspirin; Atorvastatin; Clopidogrel; Diagnosis, Differential; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Platelet Aggregation Inhibitors; Rare Diseases; Spinal Cord; Spinal Cord Ischemia; Stroke; Stroke Rehabilitation; Ticlopidine; Treatment Outcome | 2018 |
Carotid Endarterectomy and Concurrent Clopidogrel Use: National Practice Patterns in the United States.
Topics: Aged; Carotid Stenosis; Clopidogrel; Combined Modality Therapy; Databases, Factual; Endarterectomy, Carotid; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Ticlopidine; United States | 2018 |
Nonsynonymous single nucleotide polymorphisms in candidate genes P2RY1, P2RY12 and CYP2C19 for clopidogrel efficacy in cats.
Topics: Animals; Cats; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Resistance; Polymorphism, Single Nucleotide; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Ticlopidine | 2018 |
Leukocyte miR-223-3p is not associated with
altered platelet responses to clopidogrel in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Blood Platelets; Clopidogrel; Coronary Artery Disease; Humans; Leukocytes; MicroRNAs; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2018 |
Platelet Function Analyzer-200 P2Y Results Are Predictive of the Risk of Major Adverse Cardiac Events in Korean Patients Receiving Clopidogrel Therapy Following Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Aged; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Risk; Stroke; Ticlopidine | 2018 |
Dual therapy with clopidogrel and aspirin prevents early neurological deterioration in ischemic stroke patients carrying CYP2C19*2 reduced-function alleles.
Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; China; Clinical Decision-Making; Clopidogrel; Cytochrome P-450 CYP2C19; Disease Progression; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pharmacogenomic Variants; Platelet Aggregation; Platelet Aggregation Inhibitors; Precision Medicine; Prospective Studies; Stroke; Ticlopidine; Treatment Outcome | 2018 |
Left ventricular mural thrombus despite treatment with dabigatran and clopidogrel.
Topics: Aged, 80 and over; Anticoagulants; Antithrombins; Atrial Fibrillation; Clopidogrel; Dabigatran; Diagnosis, Differential; Drug Therapy, Combination; Dyspnea; Echocardiography; Fatal Outcome; Heart Diseases; Heart Failure; Humans; Male; Thrombosis; Ticlopidine; Warfarin | 2018 |
Equilibrative nucleoside transporter 1 gene polymorphisms and clinical outcomes following acute coronary syndromes: findings from the PLATelet inhibition and patient Outcomes (PLATO) study.
Topics: Acute Coronary Syndrome; Biomarkers; Blood Platelets; Cause of Death; Clopidogrel; Equilibrative Nucleoside Transporter 1; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prognosis; Proportional Hazards Models; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2019 |
Clinical Significance of Acute and Serial Platelet Function Testing in Acute Ischemic Stroke.
Topics: Acute Disease; Aged; Aspirin; Blood Platelets; Brain Ischemia; Clopidogrel; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prognosis; Prospective Studies; Ticlopidine | 2018 |
Prasugrel in the Elderly.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Humans; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2018 |
Individual long-term variation of platelet reactivity in patients with dual antiplatelet therapy after myocardial infarction.
Topics: Adult; Aged; Blood Platelets; Clopidogrel; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Time Factors; Treatment Outcome | 2019 |
Peripheral artery disease: How do genes and pharmacology interplay?
Topics: Aspirin; Clopidogrel; Humans; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Ticlopidine | 2018 |
Efficacy and safety of CYP2C19 genotype in stroke or transient ischemic attack patients treated with clopidogrel monotherapy or clopidogrel plus aspirin: Protocol for a systemic review and meta-analysis.
Topics: Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Genotype; Humans; Ischemic Attack, Transient; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Stroke; Systematic Reviews as Topic; Ticlopidine; Treatment Outcome | 2018 |
Effect of Physical Exercise on Platelet Reactivity in Patients with Dual Antiplatelet Therapy.
Topics: Adenosine Diphosphate; Aspirin; Chromogranin A; Clopidogrel; Coronary Artery Disease; Electrocardiography; Exercise; Exercise Tolerance; Humans; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thrombosis; Ticlopidine | 2018 |
Evidences about combination use of acetylsalicylic acid (aspirin) and clopidogrel in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2017 |
Secondary Stroke Prophylaxis with Clopidogrel Produces Sufficient Antiplatelet Response.
Topics: Aged; Clopidogrel; Denmark; Drug Resistance; Female; Humans; Ischemic Attack, Transient; Male; Medication Adherence; Middle Aged; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Recurrence; Risk Factors; Secondary Prevention; Stroke; Ticlopidine; Time Factors; Treatment Outcome | 2018 |
[In process].
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Risk Reduction Behavior; Ticlopidine | 2017 |
Comparison of the Effects of Ticagrelor and Clopidogrel on Inflammatory Factors, Vascular Endothelium Functions and Short-Term Prognosis in Patients with Acute ST-Segment Elevation Myocardial Infarction Undergoing Emergency Percutaneous Coronary Intervent
Topics: Adenosine; Adult; Aged; Biomarkers; C-Reactive Protein; Clopidogrel; Endothelium, Vascular; Female; Humans; Interleukin-6; Male; Middle Aged; Myocardial Infarction; Neoplasm Proteins; Percutaneous Coronary Intervention; Pilot Projects; Platelet Aggregation Inhibitors; Prognosis; Proteoglycans; Ticagrelor; Ticlopidine; Treatment Outcome | 2018 |
Association between high on-treatment platelet reactivity to clopidogrel and hepatosteatosis in patients undergoing elective stent implantation.
Topics: Case-Control Studies; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Fatty Liver; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Postoperative Complications; Preoperative Period; Prospective Studies; Stents; Ticlopidine; Treatment Outcome | 2018 |
Aspirin Plus Clopidogrel vs Aspirin Alone for Preventing Cardiovascular Events Among Patients at High Risk for Cardiovascular Events.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Review Literature as Topic; Stroke; Ticlopidine | 2018 |
Comparison of 6-Month Costs Between Oral Antiplatelet Agents Following Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Adenosine; Administration, Oral; Aged; Clopidogrel; Costs and Cost Analysis; Female; Health Care Costs; Humans; Length of Stay; Male; Middle Aged; Patient Acceptance of Health Care; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Postoperative Period; Prasugrel Hydrochloride; Retrospective Studies; Ticagrelor; Ticlopidine | 2018 |
Comparison of factors affecting platelet reactivity in various platelet function tests.
Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Ticlopidine | 2019 |
Interaction study between antiplatelet agents, anticoagulants, thyroid replacement therapy and a bioavailable formulation of curcumin (Meriva®).
Topics: Anticoagulants; Aspirin; Blood Glucose; Clopidogrel; Curcumin; Drug Compounding; Drug Interactions; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Osteoarthritis; Platelet Aggregation Inhibitors; Thyroxine; Ticlopidine; Warfarin | 2018 |
CRISPLD1 rs12115090 polymorphisms alters antiplatelet potency of clopidogrel in coronary artery disease patients in Chinese Han.
Topics: Aged; Asian People; Cell Adhesion Molecules; China; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Ticlopidine; Treatment Outcome | 2018 |
The safety of triple antiplatelet therapy under thromboelastography guidance in patients undergoing stenting for ischemic cerebrovascular disease.
Topics: Aged; Aspirin; Brain Ischemia; Cilostazol; Clopidogrel; Drug Therapy, Combination; Female; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Stroke; Thrombelastography; Ticlopidine | 2019 |
Impact of Baseline Bleeding Risk on Efficacy and Safety of Ticagrelor versus Clopidogrel in Chinese Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Treatment Outcome | 2018 |
[Synergistic Effects of Clopidogrel and Xuesaitong Dispersible Tablet by Modulating Plasma Protein Binding].
Topics: Animals; Blood Proteins; Chromatography, High Pressure Liquid; Clopidogrel; Drugs, Chinese Herbal; Ginsenosides; Humans; Rabbits; Saponins; Tablets; Ticlopidine | 2016 |
Comparison of Effects between Clopidogrel and Cilostazol on Cerebral Perfusion in Nonsurgical Adult Patients with Symptomatically Ischemic Moyamoya Disease: Subanalysis of a Prospective Cohort.
Topics: Adult; Blood Flow Velocity; Brain Ischemia; Cerebrovascular Circulation; Cilostazol; Clopidogrel; Drug Substitution; Female; Humans; Male; Middle Aged; Moyamoya Disease; Multivariate Analysis; Oxygen Radioisotopes; Perfusion Imaging; Platelet Aggregation Inhibitors; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Tetrazoles; Ticlopidine; Time Factors; Treatment Outcome | 2018 |
Effectiveness of Platelet Function Analyzer-100 for Laboratory Detection of Anti-Platelet Drug-Induced Platelet Dysfunction.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Child; Child, Preschool; Clopidogrel; Female; Humans; Infant; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Young Adult | 2019 |
Laboratory monitoring of P2Y
Topics: Acute Coronary Syndrome; Anticoagulants; Aspirin; Blood Coagulation; Cardiology; Clopidogrel; Genetic Variation; Humans; International Cooperation; Monitoring, Physiologic; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Societies, Medical; Ticlopidine | 2018 |
The association of clopidogrel and 2-oxo-clopidogrel plasma levels and the 40 months clinical outcome after primary PCI.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Chest Pain; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; ST Elevation Myocardial Infarction; Ticlopidine; Treatment Outcome | 2018 |
The association between clopidogrel and 2-oxo-clopidogrel plasma levels and the long-term clinical outcome after acute myocardial infarction
.
Topics: Clopidogrel; Humans; Ischemia; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2019 |
"No Such Thing as a Free Lunch": Personalized P2Y
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2019 |
CYP2C19 Ultrarapid Phenotype as a Risk Predictor of Subsequent Events During Clopidogrel Treatment in Patients Undergoing a Percutaneous Neurointervention.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Phenotype; Platelet Aggregation Inhibitors; Ticlopidine | 2019 |
New opportunities to optimize antithrombotic therapy for secondary stroke prevention.
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Secondary Prevention; Stroke; Ticagrelor; Ticlopidine; Treatment Outcome | 2019 |
Evaluation of adverse events involving bleeding associated with oral P2Y12 inhibitors use in the Food and Drug Administration adverse event reporting system.
Topics: Adverse Drug Reaction Reporting Systems; Clopidogrel; Hemorrhage; Humans; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticlopidine; United States; United States Food and Drug Administration | 2019 |
Prasugrel or clopidogrel for long-term secondary stroke prevention?
Topics: Brain Ischemia; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Stroke; Ticlopidine | 2019 |
Predicting clinical outcomes after clopidogrel use: easier to postulate than to prove and implement.
Topics: Clopidogrel; Erythrocyte Indices; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2019 |
Enhanced platelet inhibition by clopidogrel and risk of bleeding in patients requiring oral anticoagulation after drug-eluting stent implantation.
Topics: Anticoagulants; Clopidogrel; Drug-Eluting Stents; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine; Treatment Outcome | 2019 |
[Impact of discontinuation of aspirin and clopidogrel before off-pump coronary artery bypass grafting on postoperative bleeding and transfusion requirement].
Topics: Aged; Aspirin; Blood Transfusion; Clopidogrel; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Postoperative Hemorrhage; Retrospective Studies; Ticlopidine | 2019 |
Predictors of strut coverage of drug eluting stent implantation in diabetic patients- Is only on-clopidogrel platelet reactivity enough? Reply.
Topics: Blood Platelets; Clopidogrel; Diabetes Mellitus; Drug-Eluting Stents; Humans; Ticlopidine | 2019 |
[Status quo and countermeasure of clopidogrel resistance predicted by gene testing].
Topics: Blood Platelets; Clopidogrel; Drug Resistance; Genetic Testing; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2019 |
Efficacy of Antiplatelet Agent Usage for Primary and Secondary Prevention in Dialysis Patients: a Nationwide Data Survey and Propensity Analysis.
Topics: Aspirin; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Primary Prevention; Renal Dialysis; Secondary Prevention; Stroke; Surveys and Questionnaires; Ticlopidine | 2019 |
Predictors of strut coverage of drug eluting stent in diabetic patients - Is only on-clopidogrel platelet reactivity enough?
Topics: Blood Platelets; Clopidogrel; Diabetes Mellitus; Drug-Eluting Stents; Humans; Ticlopidine | 2019 |
A Randomized Trial of Interrupted Clopidogrel in Patients Undergoing Polypectomy: More Questions Than Answers?
Topics: Clopidogrel; Double-Blind Method; Hemorrhage; Humans; Ticlopidine | 2019 |
RE: Risk of Postpolypectomy Bleeding With Uninterrupted Clopidogrel Therapy in an Industry-Independent, Double-Blind, Randomized, Trial.
Topics: Clopidogrel; Double-Blind Method; Hemorrhage; Humans; Ticlopidine | 2019 |
Short-term Safety and Mid-term Efficacy of Prasugrel Versus Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention.
Topics: Acute Coronary Syndrome; Aged; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Retrospective Studies; Ticlopidine | 2019 |
Adherence to Antiplatelet Therapy after Coronary Intervention among Patients with Myocardial Infarction Attending Vietnam National Heart Institute.
Topics: Adult; Aspirin; Clopidogrel; Cross-Sectional Studies; Female; Heart; Humans; Income; Male; Medication Adherence; Middle Aged; Multivariate Analysis; Myocardial Infarction; Patient Discharge; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Regression Analysis; Surveys and Questionnaires; Ticlopidine; Vietnam | 2019 |
[Genetic and non-genetic factors of laboratory resistance to clopidogrel in patients with ischemic stroke].
Topics: Aryl Hydrocarbon Hydroxylases; Brain Ischemia; Clopidogrel; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Male; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2019 |
[Double antiplatelet therapy in patients with acute coronary syndrome after percutaneous coronary intervention: individual efficacy and hemorrhagic safety of P2Y12 blockers of ticagrelor and clopidogrel in actual clinical practice].
Topics: Acute Coronary Syndrome; Adenosine; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Treatment Outcome | 2019 |
Dual Antiplatelet Therapy: Is It Time to Cut the Cord With Aspirin?
Topics: Aspirin; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2019 |
Box-Behnken design directed optimization for sensitivity assessment of anti-platelet drugs.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Clopidogrel; Models, Chemical; Platelet Aggregation Inhibitors; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Ticlopidine | 2019 |
Descriptive analysis of real-world medication use pattern of statins and antiplatelet agents among patients with acute coronary syndrome in Hong Kong and the USA.
Topics: Acute Coronary Syndrome; Administration, Oral; Aged; Clopidogrel; Databases, Factual; Drug Therapy, Combination; Female; Hong Kong; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Medication Adherence; Middle Aged; Minnesota; Patient Outcome Assessment; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proportional Hazards Models; Retrospective Studies; Ticlopidine | 2019 |
Frequency and clinical outcomes of CYP2C19 genotype-guided escalation and de-escalation of antiplatelet therapy in a real-world clinical setting.
Topics: Aged; Clopidogrel; Coronary Occlusion; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Precision Medicine; Prospective Studies; Ticlopidine; Treatment Outcome | 2020 |
Association Between Residual Platelet Reactivity on Clopidogrel Treatment and Severity of Coronary Atherosclerosis: Intrinsic Hypercoagulability as a Mediator.
Topics: Aged; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Thrombelastography; Thrombophilia; Ticlopidine | 2019 |
CYP2C19 loss-of-function alleles: A common but overlooked problem associated with clopidogrel resistance.
Topics: Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2019 |
[Relation of Functional Activity of Platelets to Prognosis of Unfavorable Cardiovascular Events in Patients with Acute Coronary Syndrome. Results of a Registry Study].
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prognosis; Registries; Russia; Ticlopidine | 2019 |
Clopidogrel Pharmacogenetics - Why the Wait?
Topics: Clopidogrel; Genotype; Percutaneous Coronary Intervention; Pharmacogenetics; Platelet Aggregation Inhibitors; Ticlopidine | 2019 |
The effect of esomeprazole vs famotidine on aspirin/clopidogrel dual therapy after percutaneous coronary intervention.
Topics: Aspirin; Blood Platelets; Clopidogrel; Drug Therapy, Combination; Esomeprazole; Famotidine; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2019 |
Ticagrelor Compared to Clopidogrel in Acute Coronary Syndrome and Stable Coronary Artery Disease.
Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Clopidogrel; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Ticagrelor; Ticlopidine | 2019 |
One vs 12 Months of Dual Antiplatelet Therapy for Patients After Percutaneous Coronary Intervention.
Topics: Clopidogrel; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2019 |
1 vs 12 Months of Dual Antiplatelet Therapy for Patients After Percutaneous Coronary Intervention-Reply.
Topics: Clopidogrel; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2019 |
Distribution of polymorphisms in the CYP2C19 and ABCB1 genes among patients with acute coronary syndrome in Lower Silesian population.
Topics: Acute Coronary Syndrome; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Platelet Aggregation Inhibitors; Poland; Polymorphism, Single Nucleotide; Ticlopidine | 2019 |
Point-of-Care Guided Strategy for Clopidigrel Suspension in Patients Undergoing Coronary Surgery.
Topics: Clopidogrel; Coronary Artery Bypass; Humans; Point-of-Care Systems; Ticlopidine | 2020 |
Smoking, clopidogrel and platelet reactivity: are we still missing something?
Topics: Blood Platelets; Clopidogrel; Percutaneous Coronary Intervention; Smoking; Ticlopidine | 2020 |
Sex-specific differences in antithrombotic therapy and prognosis in patients with acute coronary syndrome treated with stent.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Clopidogrel; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Practice Patterns, Physicians'; Prognosis; Prospective Studies; Purinergic P2Y Receptor Antagonists; Sex Factors; Stents; Ticagrelor; Ticlopidine | 2019 |
Low-dose prasugrel versus clopidogrel in elderly patients with high clinical and PCI complexity.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2020 |
Aspirin plus clopidogrel versus aspirin Mono-Therapy for ischemic stroke.
Topics: Aspirin; Brain Ischemia; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2020 |
Pharmacodynamic study of prasugrel or clopidogrel in non-ST-elevation acute coronary syndrome with CYP2C19 genetic variants undergoing percutaneous coronary intervention (PRAISE-GENE trial).
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2020 |
Smoking and antiplatelet therapy after acute coronary syndromes.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Smoking; Ticlopidine | 2020 |
The ABCD-GENE Score for Clopidogrel Response: Not Just Another Cardiac Risk Model.
Topics: Clopidogrel; Platelet Aggregation Inhibitors; Prognosis; Ticlopidine; Treatment Outcome | 2020 |
Letter by Kim et al Regarding Article, "Clinically Significant Bleeding With Ticagrelor Versus Clopidogrel in Korean Patients With Acute Coronary Syndromes Intended for Invasive Management: A Randomized Clinical Trial".
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Purinergic P2Y Receptor Antagonists; Republic of Korea; Ticagrelor; Ticlopidine | 2020 |
Letter by Chen et al Regarding Article, "Clinically Significant Bleeding With Ticagrelor Versus Clopidogrel in Korean Patients With Acute Coronary Syndromes Intended for Invasive Management: A Randomized Clinical Trial".
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Purinergic P2Y Receptor Antagonists; Republic of Korea; Ticagrelor; Ticlopidine | 2020 |
Response by Park and Park to Letter Regarding Article, "Clinically Significant Bleeding With Ticagrelor Versus Clopidogrel in Korean Patients With Acute Coronary Syndromes Intended for Invasive Management: A Randomized Clinical Trial".
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Purinergic P2Y Receptor Antagonists; Republic of Korea; Ticagrelor; Ticlopidine | 2020 |
Subacute stent thrombosis in a patient with type 2 diabetes and clopidogrel resistance: A case report
.
Topics: Clopidogrel; Diabetes Mellitus, Type 2; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine | 2020 |
The Frequency of the Minor Polymorphisms in the
Topics: Acute Coronary Syndrome; Aged; Alleles; Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Ethnicity; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Polymorphism, Single Nucleotide; Russia; Siberia; Ticlopidine; Vascular Endothelial Growth Factor Receptor-2 | 2020 |
Clopidogrel is a favourable alternative to ticagrelor in older patients with NSTE-ACS.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticagrelor; Ticlopidine | 2020 |
Double Trouble: Reducing Gastrointestinal Bleeding due to DAPT Following Acute Coronary Syndromes.
Topics: Acute Coronary Syndrome; Clopidogrel; Gastrointestinal Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2021 |
[Expanding the possibilities of antithrombotic therapy of cerebrovascular pathology].
Topics: Clopidogrel; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Pilot Projects; Platelet Aggregation Inhibitors; Stroke; Ticlopidine | 2020 |
Changing paradigms in antiplatelet therapy after coronary intervention.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2021 |
Adenosine Diphosphate Receptor Inhibitors: Balancing Perioperative Bleeding and Protection From Adverse Coronary Events.
Topics: Adenosine Diphosphate; Clopidogrel; Hemorrhage; Humans; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2021 |
Time-dependent impact of Ticagrelor and Prasugrel on infarct size: Looking beyond antiplatelet effect.
Topics: Clopidogrel; Humans; Prasugrel Hydrochloride; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine | 2020 |
Clopidogrel preventive effect based on cytochrome P450 2C19 genotype in ischaemic stroke: protocol for multicentre observational study.
Topics: Brain Ischemia; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Ischemic Stroke; Multicenter Studies as Topic; Observational Studies as Topic; Platelet Aggregation Inhibitors; Prospective Studies; Stroke; Ticlopidine; Treatment Outcome | 2020 |
Decreased Platelet Inhibition by Thienopyridines in Hyperuricemia.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Angioplasty; Clopidogrel; Comorbidity; Cytochrome P-450 CYP2C9; Female; Genotype; Humans; Hyperuricemia; Male; Middle Aged; Platelet Activation; Platelet Aggregation Inhibitors; Prospective Studies; Purinergic P2Y Receptor Antagonists; Stents; Thienopyridines; Ticagrelor; Ticlopidine; Uric Acid | 2021 |
Clopidogrel-induced sweet syndrome: severe dermatological complication after percutaneous coronary intervention.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Sweet Syndrome; Ticlopidine; Treatment Outcome | 2021 |
Aspirin alone is safer than dual antiplatelet therapy in patients undergoing TAVI.
Topics: Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Transcatheter Aortic Valve Replacement | 2020 |
Association of fractalkine with functional severity of heart failure and impact on clopidogrel efficacy in patients with ischemic heart disease.
Topics: Blood Platelets; Chemokine CX3CL1; Clopidogrel; Coronary Artery Disease; Heart Failure; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Stroke Volume; Ticlopidine; Ventricular Function, Left | 2020 |
Impact of the rs73598374 polymorphism of the adenosine deaminase gene on platelet reactivity and long-term outcomes among patients with acute coronary syndrome treated with ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine Deaminase; Aftercare; Clopidogrel; Drug Therapy, Combination; Humans; Patient Discharge; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2020 |
Aspirin Monotherapy vs. DAPT after TAVI: Is Less More? Comment on the POPular TAVI Trial.
Topics: Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Transcatheter Aortic Valve Replacement | 2020 |
Cilostazol plus clopidogrel in the prevention of in-stent stenosis after vertebral artery origin stenting in gout patients: three case reports.
Topics: Aged; Brain Ischemia; Cilostazol; Clopidogrel; Constriction, Pathologic; Drug Therapy, Combination; Gout; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Stents; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome; Vertebral Artery | 2020 |
Topics: Clopidogrel; Humans; Ischemic Attack, Transient; Precision Medicine; Stroke; Ticlopidine | 2021 |
Ultrashort 1- to 3-month double antiplatelet therapy after drug-eluting stent implantation or the conquest of the South Pole.
Topics: Clopidogrel; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2021 |
Validation of the ABCD-GENE score to identify high platelet reactivity in east Asian patients undergoing percutaneous coronary intervention.
Topics: Blood Platelets; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Treatment Outcome | 2021 |
Effect of bodyweight on VerifyNow Aspirin platelet function test: a retrospective review.
Topics: Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Retrospective Studies; Ticlopidine | 2021 |
Impact of selected genetic factors on clopidogrel inactive metabolite level and antiplatelet response in patients after percutaneous coronary intervention.
Topics: Aged; Alleles; Chromatography, High Pressure Liquid; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Prospective Studies; Ticlopidine | 2021 |
Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Acute Coronary Syndrome: Implications for Platelet Reactivity?
Topics: Acute Coronary Syndrome; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Clopidogrel; Dual Anti-Platelet Therapy; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Ticlopidine | 2021 |
Efficacy of aspirin, clopidogrel, and ticlopidine in stroke prevention: A population-based case-cohort study in Taiwan.
Topics: Adult; Aged; Aspirin; Brain Ischemia; Clopidogrel; Cohort Studies; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Propensity Score; Recurrence; Secondary Prevention; Stroke; Taiwan; Ticlopidine | 2020 |
[One case report of insulin autoimmune syndrome induced by clopidogrel].
Topics: Autoimmune Diseases; Clopidogrel; Humans; Insulins; Platelet Aggregation Inhibitors; Ticlopidine | 2021 |
Cost-effectiveness of CYP2C19-guided antiplatelet therapy for acute coronary syndromes in Singapore.
Topics: Acute Coronary Syndrome; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Drug Costs; Genotype; Humans; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Singapore; Ticagrelor; Ticlopidine | 2021 |
Risk of postpolypectomy bleeding in patients taking direct oral anticoagulants or clopidogrel.
Topics: Administration, Oral; Aged; Anticoagulants; Clopidogrel; Colonic Polyps; Colonoscopy; Female; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Risk Factors; Thromboembolism; Ticlopidine; Warfarin | 2021 |
The effect of ticagrelor on microarterial thrombosis in an experimental model.
Topics: Adenosine; Animals; Clopidogrel; Models, Theoretical; Platelet Aggregation Inhibitors; Rats; Thrombosis; Ticagrelor; Ticlopidine | 2021 |
Generic Clopidogrel: Has Substitution for Brand Name Plavix® Been Effective?
Topics: Clopidogrel; Drugs, Generic; Female; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2022 |
Ticagrelor vs Clopidogrel for Patients With Acute Coronary Syndrome Undergoing Percutaneous Intervention-Reply.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2021 |
MORPHOLOGICAL CHANGES OF THE GASTRIC MUCOSA WHILE USING ANTIAGGREGANTS AND PANTOPRAZOLE (AN EXPERIMENTAL STUDY).
Topics: Animals; Aspirin; Clopidogrel; Gastric Mucosa; Male; Pantoprazole; Rats; Ticlopidine | 2021 |
Prasugrel switching from clopidogrel after percutaneous coronary intervention for acute coronary syndrome in Taiwanese patients: an analysis of safety and efficacy.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine; Treatment Outcome | 2022 |
Stronger inhibitory effects of Ticagrelor plus aspirin compared with Clopidogrel plus aspirin on arachidonic acid-induced platelet aggregation in patients with acute coronary syndrome with PCI.
Topics: Acute Coronary Syndrome; Adenosine; Arachidonic Acid; Aspirin; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2021 |
Assessment of therapeutic platelet inhibition in cardiac patients: Comparative study between VerifyNow-P2Y12 and Anysis-P2Y12 assay.
Topics: Blood Platelets; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2021 |
Serum Free Triiodothyronine and the Responsiveness to Clopidogrel in Patients Undergoing Elective Percutaneous Coronary Intervention.
Topics: Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome; Triiodothyronine | 2021 |
Platelet aggregometry for hip fracture surgery in patients treated with clopidogrel: a pilot study.
Topics: Adenosine Diphosphate; Blood Platelets; Clopidogrel; Hip Fractures; Humans; Pilot Projects; Platelet Aggregation Inhibitors; Ticlopidine | 2022 |
Original and generic clopidogrel: A comparison of antiplatelet effects and active metabolite concentrations in patients without polymorphisms in the ABCB1 gene and the allele variants CYPC19*2 and *3.
Topics: Alleles; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2021 |
Letter to the Editor: How Should We Treat High-risk Patients in the Chronic Phase Following PCI: Clopidogrel or Prolonged DAPT?
Topics: Aspirin; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2021 |
Cost-Effectiveness of Ticagrelor Compared with Clopidogrel in Patients with Acute Coronary Syndrome from Vietnamese Healthcare Payers' Perspective.
Topics: Acute Coronary Syndrome; Adenosine; Asian People; Clopidogrel; Cost-Benefit Analysis; Drug Costs; Humans; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2021 |
Pre-treatment with dual antiplatelet therapy in non-ST-segment elevation acute coronary syndromes: landing from guidelines recommendations to real-world ground.
Topics: Acute Coronary Syndrome; Clopidogrel; Dual Anti-Platelet Therapy; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2021 |
Challenging the Role of Aspirin for Long-Term Antiplatelet Therapy?
Topics: Aspirin; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2021 |
Association of lipoprotein(a) with intrinsic and on-clopidogrel platelet reactivity.
Topics: Blood Platelets; Clopidogrel; Humans; Lipoprotein(a); Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine | 2022 |
Differential Impact of Clinical and Genetic Factors on High Platelet Reactivity in Patients with Coronary Artery Disease Treated with Clopidogrel and Prasugrel.
Topics: Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Diabetes Mellitus; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Renal Insufficiency, Chronic; Ticlopidine | 2022 |
Proton Pump Inhibitor and Clopidogrel Use After Percutaneous Coronary Intervention and Risk of Major Cardiovascular Events.
Topics: Clopidogrel; Cohort Studies; Coronary Disease; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome | 2022 |
Safety of early surgery for geriatric hip fracture patients taking clopidogrel: a retrospective case-control study of 120 patients in China.
Topics: Aged; Case-Control Studies; Clopidogrel; Hip Fractures; Humans; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2021 |
Balancing Benefits and Risks of Long-Term Antiplatelet Therapy in Noncardioembolic Transient Ischemic Attack or Stroke.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Humans; Intracranial Hemorrhages; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk Assessment; Stroke; Ticlopidine; Treatment Outcome | 2021 |
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.
Topics: Animals; Blood Platelets; Clopidogrel; Humans; Mice; Obesity; Overweight; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2022 |
Platelet Function Testing Is Required for Intracranial Stent Placement.
Topics: Clopidogrel; Humans; Platelet Function Tests; Stents; Ticlopidine | 2021 |
The comparison between the effects of aspirin and clopidogrel monotherapy on postoperative bleeding in diabetic patients after off-pump coronary artery bypass surgery.
Topics: Aspirin; Clopidogrel; Coronary Artery Bypass, Off-Pump; Diabetes Mellitus; Humans; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2021 |
Utility of a pharmacogenetic-driven algorithm in guiding dual antiplatelet therapy for patients undergoing coronary drug-eluting stent implantation in China.
Topics: Aged; Algorithms; Asian People; Aspirin; Cardiovascular Diseases; China; Clopidogrel; Comorbidity; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Dual Anti-Platelet Therapy; Female; Health Behavior; Hemorrhage; Humans; Male; Middle Aged; Pharmacogenetics; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Risk Assessment; Risk Factors; Sociodemographic Factors; Ticagrelor; Ticlopidine | 2022 |
Clinical Outcomes After Percutaneous Coronary Intervention Over Time on the Basis of CYP2C19 Polymorphisms.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine; Treatment Outcome | 2022 |
Influence of
Topics: Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Humans; MicroRNAs; Platelet Aggregation Inhibitors; Ticlopidine | 2021 |
Impact of Pancreatic β-Cell Function on Clopidogrel Responsiveness and Outcomes in Chinese Nondiabetic Patients Undergoing Elective Percutaneous Coronary Intervention.
Topics: Clopidogrel; Diabetes Mellitus, Type 2; East Asian People; Humans; Insulin Resistance; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2023 |
Dual Antiplatelet Therapy Plus Argatroban Prevents Early Neurological Deterioration in Branch Atherosclerosis Disease.
Topics: Arginine; Aspirin; Atherosclerosis; Brain Ischemia; Clopidogrel; Humans; Pipecolic Acids; Platelet Aggregation Inhibitors; Stroke; Sulfonamides; Ticlopidine | 2022 |
CYP2C19 Genotyping to Risk Stratify Patients After Coronary Stent Implantation: Time for a Personalized Approach?
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2022 |
Clopidogrel resistance in dual antiplatelet therapy after carotid stenting.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Stents; Ticlopidine | 2021 |
Topics: Aspirin; Case-Control Studies; Clopidogrel; Coronary Restenosis; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Genotype; Humans; Incidence; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Retrospective Studies; Ticlopidine; Treatment Outcome | 2021 |
Platelet function assessed by ROTEM
Topics: Aspirin; Clopidogrel; Deamino Arginine Vasopressin; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Ticlopidine; Vascular Surgical Procedures | 2022 |
Associations of CYP2C19 and F2R genetic polymorphisms with platelet reactivity in Chinese ischemic stroke patients receiving clopidogrel therapy.
Topics: Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Ischemic Stroke; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stroke; Ticlopidine; Treatment Outcome | 2022 |
Clinical and Pharmacological Parameters Determine Relapse During Clopidogrel Treatment of Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Aspirin; Calcium Channel Blockers; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Diabetes Mellitus, Type 2; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Ticlopidine; Treatment Outcome | 2022 |
Clopidogrel resistance is common in patients undergoing vascular and coronary interventions.
Topics: Blood Platelets; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Treatment Outcome | 2023 |
COX-1, COX-2 and CYP2C19 variations may be related to cardiovascular events due to acetylsalicylic acid resistance.
Topics: Aspirin; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase 2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Resistance; Genotype; Humans; Platelet Aggregation Inhibitors; Stents; Thrombosis; Ticlopidine | 2022 |
CYP2C19 polymorphisms and clopidogrel efficacy in the secondary prevention of ischemic stroke: a retrospective observational study.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Ischemic Stroke; Platelet Aggregation Inhibitors; Secondary Prevention; Ticlopidine; Treatment Outcome | 2021 |
Influence of Clinically Significant Genes on Antiplatelet Effect of Clopidogrel and Clinical Outcomes in Patients with Acute Coronary Syndrome and Atrial Fibrillation.
Topics: Acute Coronary Syndrome; Aryldialkylphosphatase; Atrial Fibrillation; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Receptors, Cell Surface; Ticlopidine; Treatment Outcome | 2022 |
Clopidogrel or ticagrelor in elderly patients with acute coronary syndromes - Nihil nocere!
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticagrelor; Ticlopidine; Treatment Outcome | 2022 |
Effect of CYP2C19 status on platelet reactivity in Taiwanese acute coronary syndrome patients switching to prasugrel from clopidogrel: Switch Study.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Ticlopidine | 2022 |
Relationship between recurrent ischemic events in cerebrovascular disease and cytochrome P450 2C19 gene polymorphism on the basis of thrombelastography.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Stroke; Thrombelastography; Ticlopidine | 2022 |
Time for a paradigm shift? Making the case for tailored selection of antiplatelet therapy.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2022 |
Clopidogrel Monotherapy More Effective Than Aspirin to Prevent Coronary Events After PCI With Drug-Eluting Stents.
Topics: Aspirin; Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Stents; Ticlopidine; Treatment Outcome | 2022 |
Being Overweight or Obese Is Associated with an Increased Platelet Reactivity Despite Dual Antiplatelet Therapy with Aspirin and Clopidogrel.
Topics: Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Clopidogrel; Humans; Obesity; Overweight; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticagrelor; Ticlopidine | 2023 |
Study on the Interaction between Deuterium Clopidogrel and Omeprazole.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Deuterium; Drug Interactions; Drug Therapy, Combination; Humans; Isoenzymes; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Tandem Mass Spectrometry; Ticlopidine | 2022 |
Antiplatelet response to clopidogrel is associated with a haplotype in CYP2C19 gene in Pakistani patients.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Haplotypes; Humans; Ischemia; Pakistan; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2022 |
Cost Utility of Prasugrel in Postangioplasty Diabetic Patients.
Topics: Clopidogrel; Diabetes Mellitus; Hemorrhage; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Quality of Life; Ticlopidine | 2022 |
Performance of the ABCD-GENE Score for Predicting Clinical Outcomes in Clopidogrel-Treated Patients with ACS.
Topics: Acute Coronary Syndrome; Blood Platelets; Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2022 |
Circadian variations of platelet reactivity on clopidogrel in patients treated with elective percutaneous coronary intervention.
Topics: Blood Platelets; Clopidogrel; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2022 |
Dual Antiplatelet Therapy Discontinuation, Platelet Reactivity, and Adverse Outcomes After Successful Percutaneous Coronary Intervention.
Topics: Clopidogrel; Coronary Artery Disease; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome | 2022 |
Future of antithrombotic therapy for heart failure with coronary artery disease.
Topics: Clopidogrel; Coronary Artery Disease; Fibrinolytic Agents; Heart Failure; Humans; Ticlopidine | 2022 |
The Cytochrome P450 2C19 Polymorphism Associated with Major Adverse Cardiovascular Events Risk in Kazak Patients Undergoing Percutaneous Coronary Intervention and Receiving Clopidogrel.
Topics: Acute Coronary Syndrome; China; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2023 |
Cost-Effectiveness of Cilostazol Added to Aspirin or Clopidogrel for Secondary Prevention After Noncardioembolic Stroke.
Topics: Aspirin; Cilostazol; Clopidogrel; Cost-Benefit Analysis; Humans; Markov Chains; Platelet Aggregation Inhibitors; Quality-Adjusted Life Years; Secondary Prevention; Stroke; Ticlopidine | 2022 |
Clopidogrel Resistance Among Ischemic Stroke Patients and Its Risk Factors in Indonesia.
Topics: Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Humans; Indonesia; Ischemic Stroke; Male; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine; Treatment Outcome | 2022 |
Cost-effectiveness of clopidogrel vs. ticagrelor in patients of 70 years or older with non-ST-elevation acute coronary syndrome.
Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Cost-Benefit Analysis; Humans; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine | 2022 |
Cost-effectiveness of testing for CYP2C19 loss-of-function carriers following transient ischemic attack/minor stroke: A Canadian perspective.
Topics: Aspirin; Canada; Clopidogrel; Cost-Benefit Analysis; Cytochrome P-450 CYP2C19; Humans; Ischemic Attack, Transient; Platelet Aggregation Inhibitors; Quality of Life; Quality-Adjusted Life Years; Stroke; Ticagrelor; Ticlopidine | 2023 |
Effect of body weight on bleeding events of aspirin in ischemic stroke or transient ischemic attack patients.
Topics: Aspirin; Body Weight; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Ischemic Attack, Transient; Ischemic Stroke; Platelet Aggregation Inhibitors; Retrospective Studies; Selective Serotonin Reuptake Inhibitors; Stroke; Ticlopidine; Treatment Outcome | 2022 |
A study of microRNA-223 in evaluating platelet reactivity in patients with acute ischemic stroke.
Topics: Adenosine Diphosphate; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Ischemic Stroke; MicroRNAs; Platelet Aggregation Inhibitors; Ticlopidine | 2022 |
P2Y12 reaction units and ischemic and bleeding events after neuro-endovascular treatment.
Topics: Aspirin; Clopidogrel; Endovascular Procedures; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2022 |
Perioperative Management of Clopidogrel: Also Pay Attention to Highly Responsive Patients.
Topics: Clopidogrel; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 2023 |
Semi-mechanistic population pharmacokinetics analysis reveals distinct CYP2C19 dependency in the bioactivation of vicagrel and clopidogrel to active metabolite M15-2.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Galanin; Humans; Phenylacetates; Platelet Aggregation Inhibitors; Substance P; Thiophenes; Ticlopidine | 2022 |
Discordance in tests used to detect inhibition of the P2Y12 receptor in patients undergoing interventional neuroradiology procedures.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Ticlopidine | 2023 |
The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance.
Topics: Acute Coronary Syndrome; Albumins; Blood Platelets; Clopidogrel; Cyclic AMP Response Element-Binding Protein A; Glycated Hemoglobin; Humans; Platelet Aggregation Inhibitors; RNA, Messenger; Ticlopidine; Uric Acid | 2022 |
The Smart(est) Choice for Dual Antiplatelet Therapy Is a Patient-Directed One.
Topics: Clopidogrel; Dual Anti-Platelet Therapy; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2022 |
Impact of renal failure and high-platelet reactivity on major cardiovascular ischemic events among patients with acute coronary syndrome receiving dual antiplatelet therapy with ticagrelor.
Topics: Acute Coronary Syndrome; Adenosine; Aftercare; Clopidogrel; Humans; Patient Discharge; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Renal Insufficiency; Renal Insufficiency, Chronic; Ticagrelor; Ticlopidine | 2023 |
Elevated serum C1q is an independent predictor of high residual platelet reactivity in CAD patients receiving clopidogrel therapy.
Topics: Adenosine; Adenosine Diphosphate; Clopidogrel; Complement C1q; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticagrelor; Ticlopidine | 2022 |
Oral P2Y12 inhibiting therapy in patients with acute coronary syndrome: finding the sweet spot.
Topics: Acute Coronary Syndrome; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2023 |
Relationship between CYP2C19 Polymorphism and Clopidogrel Resistance in Patients with Coronary Heart Disease and Ischemic Stroke in China.
Topics: Aged; Aspirin; Cerebral Infarction; China; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Genotype; Humans; Ischemic Stroke; Middle Aged; Polymorphism, Genetic; Ticlopidine | 2022 |
Comparison of Cilostazol versus Clopidogrel in Addition to Aspirin in Patients with Ischemic Stroke who Underwent Intracranial or Extracranial Artery Stent Implantation.
Topics: Arteries; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Ischemic Stroke; Platelet Aggregation Inhibitors; Retrospective Studies; Stents; Stroke; Tetrazoles; Ticlopidine; Treatment Outcome | 2023 |
Time from blood draw to multiple electrode aggregometry and association with platelet reactivity.
Topics: Adenosine Diphosphate; Aged; Blood Platelets; Clopidogrel; Cohort Studies; Electrodes; Female; Humans; Male; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2023 |
Systemic Barriers and Potential Concerns from Reporting Serious Adverse Drug Reactions.
Topics: Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Humans; Immunotherapy; Thalidomide; Ticlopidine; United States | 2022 |
High On-Treatment Platelet Reactivity: Aspirin versus Clopidogrel.
Topics: Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Female; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Retrospective Studies; Ticlopidine | 2023 |
The Role of Global and Local Ancestry on Clopidogrel Response in African Americans.
Topics: Black or African American; Clopidogrel; Computational Biology; Cytochrome P-450 CYP2C19; Humans; Platelet Aggregation Inhibitors; Ticlopidine | 2023 |
Long-Term P2Y
Topics: Aspirin; Clopidogrel; Drug Therapy, Combination; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Ticlopidine; Treatment Outcome | 2023 |
The impact of high on-treatment platelet reactivity and fibrinogen levels on ischemic events in patients with ST elevation myocardial infarction: a prospective observational study.
Topics: Adenosine; Aspirin; Clopidogrel; Fibrinogen; Humans; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; ST Elevation Myocardial Infarction; Ticagrelor; Ticlopidine; Treatment Outcome | 2023 |
The Effectiveness of Antiplatelet Therapy and the Factors Influencing It in Patients with Acute Coronary Syndrome before and during the COVID-19 Pandemic.
Topics: Acute Coronary Syndrome; Adenosine; Aspirin; Clopidogrel; COVID-19; Drug Therapy, Combination; Humans; Male; Pandemics; Percutaneous Coronary Intervention; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Ticagrelor; Ticlopidine; Treatment Outcome | 2022 |
Natural history of antiplatelet nonresponders undergoing carotid artery stenting.
Topics: Carotid Arteries; Carotid Stenosis; Clopidogrel; Humans; Prospective Studies; Stents; Thromboembolism; Ticlopidine | 2023 |
Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1.
Topics: Activation, Metabolic; Animals; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP3A; Mice; Mice, Nude; Platelet Aggregation; Platelet Aggregation Inhibitors; T-Lymphocytes; Ticlopidine | 2023 |
Roles of light transmission aggregometry and CYP2C19 genotype in predicting ischaemic complications during interventional therapy for intracranial aneurysms.
Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Ticlopidine | 2023 |
Time Course of Death After Acute Coronary Syndrome Treated With Dual Antiplatelet Therapy for 1 Year.
Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticagrelor; Ticlopidine; Treatment Outcome | 2023 |
miR-6076 rs1463411 polymorphisms are associated with bleeding during clopidogrel treatment in patients with acute coronary syndrome.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Hemorrhage; Humans; MicroRNAs; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2023 |
Efficacy of Treatment with and without Initial Clopidogrel Loading in Branch Atheromatous Disease.
Topics: Cerebral Infarction; Clopidogrel; Humans; Plaque, Atherosclerotic; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Ticlopidine; Treatment Outcome | 2023 |
Multiple genetic mutations increase the risk of thrombosis associated with clopidogrel after percutaneous coronary intervention.
Topics: Aryldialkylphosphatase; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Thrombosis; Ticlopidine; Treatment Outcome | 2023 |
Clopidogrel: still king of the ring for elective percutaneous coronary intervention!
Topics: Clopidogrel; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2023 |
Clinical Impact of CYP2C19 Genotype on Clopidogrel-Based Antiplatelet Therapy After Percutaneous Coronary Intervention.
Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Drug-Eluting Stents; Genotype; Humans; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome | 2023 |
Decreased platelet miR-199a-5p level might lead to high on-clopidogrel platelet reactivity in patients with coronary artery disease.
Topics: Blood Platelets; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Humans; MicroRNAs; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Ticlopidine | 2023 |
Impact of continued clopidogrel use on outcomes of patients undergoing carotid endarterectomy.
Topics: Aged; Aspirin; Carotid Stenosis; Clopidogrel; Endarterectomy, Carotid; Female; Humans; Male; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Risk Factors; Stroke; Ticlopidine; Treatment Outcome; Warfarin | 2023 |
Monitoring of Antiplatelet Therapy.
Topics: Blood Platelets; Clopidogrel; Humans; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine | 2023 |
Atorvastatin Effect on Clopidogrel Efficacy in Patients with Peripheral Artery Disease.
Topics: Anticoagulants; Aspirin; Atorvastatin; Clopidogrel; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Peripheral Arterial Disease; Platelet Aggregation Inhibitors; Prospective Studies; Ticlopidine; Treatment Outcome; Venous Thromboembolism | 2023 |
Risk factors for gastrointestinal bleeding in patients with cerebral infarction after dual antiplatelet therapy.
Topics: Aspirin; Cerebral Infarction; Clopidogrel; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Hypertension; Peptic Ulcer; Platelet Aggregation Inhibitors; Retrospective Studies; Risk Factors; Ticlopidine | 2023 |
Variability of response on prophylactic prasugrel for endovascular treatment of intracranial aneurysms: Clinical implications.
Topics: Clopidogrel; Humans; Intracranial Aneurysm; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Retrospective Studies; Ticlopidine; Treatment Outcome | 2023 |
Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report.
Topics: Clopidogrel; Humans; Platelet Aggregation Inhibitors; Purpura, Thrombotic Thrombocytopenic; Renal Insufficiency, Chronic; Ticlopidine | 2023 |
Investigation of Platelet Function Analyzer 200 platelet function measurements in healthy cats and cats receiving clopidogrel.
Topics: Animals; Blood Platelets; Cats; Clopidogrel; Hemostasis; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Retrospective Studies; Ticlopidine | 2023 |
Differential inhibition of platelet function by cilostazol in combination with clopidogrel.
Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Tetrazoles; Ticlopidine | 2023 |
Comparative effectiveness of dual antiplatelet therapy versus monotherapy in patients with ischemic stroke.
Topics: Aspirin; Clopidogrel; Cross-Sectional Studies; Drug Therapy, Combination; Humans; Ischemic Stroke; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Ticlopidine; Treatment Outcome | 2023 |