Page last updated: 2024-08-16

ticlopidine and alprostadil

ticlopidine has been researched along with alprostadil in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19904 (11.76)18.7374
1990's8 (23.53)18.2507
2000's10 (29.41)29.6817
2010's12 (35.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Cazenave, JP; Defreyn, G; Driot, F; Gachet, C; Maffrand, JP; Savi, P1
Bouloux, C; Cazenave, JP; Defreyn, G; Driot, F; Gachet, C; Maffrand, JP; Ohlmann, P1
Jönsson, BA; Norgren, L; Strand, SE; Thörne, LJ1
Charbonnier, R; Pistone, MA; Resegotti, L; Testa, D; Toselli, P; Vivalda, S1
Battais, E; Bonne, C1
Aubert, D; Ferrand, C; Loubrie, JC; Tuong, A; Tuong, CC1
Akkawat, B; Cattaneo, M; Cimminiello, C; Kinlough-Rathbone, RL; Mannucci, PM; Packham, MA1
Kirichenko, AA; Prekina, VI1
Fukushi, H; Imura, Y; Kawamura, M; Kita, S; Moriya, N; Nishikawa, K; Sugihara, H; Terashita, Z1
Reimann, S; Schrör, K; Weber, AA1
Brich, J; Eigenthaler, M; Geiger, J; Herbert, JM; Hönig-Liedl, P; Schanzenbächer, P; Walter, U1
Belcher, G; Horrocks, M; Watson, HR1
Fischer, M; Marsch, WC; Wohlrab, J1
Akimaru, S; Ito, H; Katsube, N; Maegawa, H; Marsala, M; Nakai, K; Takenobu, Y; Takimizu, H1
Behan, MW; Fox, SC; Heptinstall, S1
Atar, D; Defranco, A; Mahmud, E; Malinin, A; Pokov, A; Schwartz, D; Schwartz, K; Serebruany, V; Spergling, M1
Asai, F; Hagihara, K; Hashimoto, M; Jakubowski, JA; Kurihara, A; Niitsu, Y; Ogawa, T; Sugidachi, A1
Ishikawa, O; Nagai, Y; Okada, E1
Diodati, JG; Lordkipanidzé, M; Nguyen, TA; Pharand, C; Schampaert, E1
Price, MJ; Teirstein, PS1
Gouya, G; Jilma, B; Siller-Matula, JM; Wolzt, M1
Desta, Z; Flockhart, DA; Jin, Y; Kovacs, R; Kreutz, RP; Kreutz, Y; Miao, J; Nystrom, P1
Bauersachs, J; Flierl, U; Fraccarollo, D; Lausenmeyer, E; Massberg, S; Rosenstock, T; Schäfer, A; Schulz, C1
Khachikyan, MV; Khaspekova, SG; Mazurov, AV; Ruda, MY; Yakushkin, VV; Zyuryaev, IT1
Bagoly, Z; Csiba, L; Kappelmayer, J; Magyar, T; Muszbek, L; Pongrácz, E; Sarkady, F1
Dhillon, K; Dovlatova, N; Fox, SC; Glenn, JR; Heptinstall, S; White, AE1
Curzen, N; Englyst, N; Hobson, A; Khanna, V; Mikael, R; Sambu, N1
Galuszka, J; Hlusi, A; Hutyra, M; Indrak, K; Indrakova, J; Krcova, V; Slavik, L; Ulehlova, J1
Chirkov, YY; De Caterina, R; Horowitz, JD; Hurst, NL; Nooney, VB1
Lee, JH; Park, TK; Shin, SJ1

Reviews

3 review(s) available for ticlopidine and alprostadil

ArticleYear
[Ticlid : clinical use and current concepts about the mechanism of action].
    Klinicheskaia meditsina, 1993, Volume: 71, Issue:4

    Topics: Alprostadil; Hemostasis; Humans; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombosis; Ticlopidine; Treatment Outcome

1993
Adjuvant medical therapy in peripheral bypass surgery.
    The British journal of surgery, 1999, Volume: 86, Issue:8

    Topics: Alprostadil; Anticoagulants; Aspirin; Chemotherapy, Adjuvant; Clinical Trials as Topic; Dextrans; Double-Blind Method; Femoral Artery; Heparin, Low-Molecular-Weight; Humans; Iloprost; Ischemia; Leg; Platelet Aggregation Inhibitors; Popliteal Artery; Prospective Studies; Randomized Controlled Trials as Topic; Ticlopidine; Vascular Surgical Procedures

1999
[Current therapy of Sneddon's syndrome].
    Deutsche medizinische Wochenschrift (1946), 2001, Jun-22, Volume: 126, Issue:25-26

    Topics: Alprostadil; Antihypertensive Agents; Blood Circulation; Captopril; Fibrinolytic Agents; Humans; Prognosis; Risk Factors; Smoking; Sneddon Syndrome; Ticlopidine

2001

Trials

3 trial(s) available for ticlopidine and alprostadil

ArticleYear
Monitoring platelet inhibition after clopidogrel with the VerifyNow-P2Y12(R) rapid analyzer: the VERIfy Thrombosis risk ASsessment (VERITAS) study.
    Thrombosis research, 2007, Volume: 119, Issue:3

    Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Blood Platelets; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Stents; Thrombosis; Ticlopidine

2007
Assessment of VerifyNow P2Y12 assay accuracy in evaluating clopidogrel-induced platelet inhibition.
    Therapeutic drug monitoring, 2008, Volume: 30, Issue:3

    Topics: Adenosine Diphosphate; Adult; Alprostadil; Clopidogrel; Double-Blind Method; Female; Humans; Male; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prospective Studies; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sample Size; Ticlopidine

2008
Cross validation of the Multiple Electrode Aggregometry. A prospective trial in healthy volunteers.
    Thrombosis and haemostasis, 2009, Volume: 102, Issue:2

    Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Aspirin; Clopidogrel; Electrodes; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Time Factors; Young Adult

2009

Other Studies

28 other study(ies) available for ticlopidine and alprostadil

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Ticlopidine and clopidogrel (SR 25990C) selectively neutralize ADP inhibition of PGE1-activated platelet adenylate cyclase in rats and rabbits.
    Thrombosis and haemostasis, 1991, Feb-12, Volume: 65, Issue:2

    Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Clopidogrel; Enzyme Activation; Female; In Vitro Techniques; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Stereoisomerism; Ticlopidine

1991
The thienopyridine ticlopidine selectively prevents the inhibitory effects of ADP but not of adrenaline on cAMP levels raised by stimulation of the adenylate cyclase of human platelets by PGE1.
    Biochemical pharmacology, 1990, Dec-15, Volume: 40, Issue:12

    Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Bleeding Time; Blood Platelets; Calcium; Cyclic AMP; Cytoplasm; Enzyme Activation; Epinephrine; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine

1990
Effect of ticlopidine and prostaglandin E on endotoxin-induced pulmonary platelet sequestration in vivo.
    Circulatory shock, 1986, Volume: 20, Issue:1

    Topics: Alprostadil; Animals; Anticoagulants; Blood Platelets; Endotoxins; Indium; Lung; Platelet Aggregation; Platelet Count; Rabbits; Radionuclide Imaging; Shock, Septic; Ticlopidine

1986
[Bone marrow culture in patients treated with Ticlopidine].
    Nouvelle revue francaise d'hematologie, 1985, Volume: 27, Issue:1

    Topics: Adult; Aged; Agranulocytosis; Alprostadil; Anticoagulants; Bone Marrow; Cells, Cultured; Colony-Forming Units Assay; Female; Granulocytes; Humans; Male; Middle Aged; Prostaglandins E; Thiophenes; Ticlopidine

1985
Ticlopidine and adenylate cyclase.
    Agents and actions. Supplements, 1984, Volume: 15

    Topics: Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Enzyme Activation; Male; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thiophenes; Ticlopidine

1984
Modulation of the inhibitory action of prostaglandin E1 on platelet aggregation in rats: a study with ticlopidine, aspirin, dipyridamole and sulfinpyrazone.
    Biochemical pharmacology, 1982, Mar-15, Volume: 31, Issue:6

    Topics: Adenosine Diphosphate; Alprostadil; Animals; Aspirin; Dipyridamole; Male; Phosphorylation; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains; Sulfinpyrazone; Thiophenes; Ticlopidine

1982
Ticlopidine facilitates the deaggregation of human platelets aggregated by thrombin.
    Thrombosis and haemostasis, 1994, Volume: 71, Issue:1

    Topics: Adenosine Diphosphate; Aged; Alprostadil; Chymotrypsin; Female; Fibrinolysin; Hirudins; Humans; Male; Middle Aged; Platelet Aggregation; Thrombin; Ticlopidine

1994
Antithrombotic effects of TAK-029, a novel GPIIb/IIIa antagonist, in guinea pigs: comparative studies with ticlopidine, clopidogrel, aspirin, prostaglandin E1 and argatroban.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:1

    Topics: Alprostadil; Animals; Arginine; Aspirin; Clopidogrel; Dogs; Fibrinolytic Agents; Guanidines; Guinea Pigs; Humans; Macaca fascicularis; Male; Pipecolic Acids; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pyrazines; Sulfonamides; Ticlopidine

1996
Specific inhibition of ADP-induced platelet aggregation by clopidogrel in vitro.
    British journal of pharmacology, 1999, Volume: 126, Issue:2

    Topics: Adenosine Diphosphate; Alprostadil; Apyrase; Blood Platelets; Clopidogrel; Cyclic AMP; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Serum Albumin; Stereoisomerism; Ticlopidine; Time Factors

1999
Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel.
    Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:8

    Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Calcium; Clopidogrel; Cyclic AMP; Epinephrine; Female; Humans; Male; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Ticlopidine; Vasodilator Agents

1999
Effects of OP-1206 alpha-CD on walking dysfunction in the rat neuropathic intermittent claudication model: comparison with nifedipine, ticlopidine and cilostazol.
    Prostaglandins & other lipid mediators, 2003, Volume: 71, Issue:3-4

    Topics: Alprostadil; Animals; Body Weight; Cilostazol; Disease Models, Animal; Exercise Test; Intermittent Claudication; Male; Nifedipine; Platelet Aggregation; Rats; Rats, Wistar; Skin; Spinal Cord; Tetrazoles; Ticlopidine; Time Factors; Walking

2003
Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1.
    Cell calcium, 2004, Volume: 35, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Alprostadil; Calcium; Calcium Signaling; Clopidogrel; Cytoplasm; Dose-Response Relationship, Drug; Drug Synergism; Humans; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors

2004
The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite.
    Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:7

    Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Clopidogrel; Cyclic AMP; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Rats; Rats, Sprague-Dawley; Thiophenes; Ticlopidine

2007
A case of widespread livedoid vasculopathy with pain but no systemic symptoms.
    Acta dermato-venereologica, 2008, Volume: 88, Issue:3

    Topics: Adult; Alprostadil; Aspirin; Biopsy; Blood Sedimentation; C-Reactive Protein; Female; Humans; Hyperesthesia; Lymphocytes; Platelet Aggregation Inhibitors; Skin; Skin Diseases, Vascular; Ticlopidine; Vasodilator Agents

2008
Dynamics of platelet functional recovery following a clopidogrel loading dose in healthy volunteers.
    The American journal of cardiology, 2008, Sep-15, Volume: 102, Issue:6

    Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Clopidogrel; Drug Monitoring; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Point-of-Care Systems; Recovery of Function; Ticlopidine

2008
Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin.
    Platelets, 2013, Volume: 24, Issue:2

    Topics: Adenosine Diphosphate; Aged; Alprostadil; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Diabetes Mellitus; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticlopidine

2013
Fractalkine activates a signal transduction pathway similar to P2Y12 and is associated with impaired clopidogrel responsiveness.
    Arteriosclerosis, thrombosis, and vascular biology, 2012, Volume: 32, Issue:8

    Topics: Adenosine Diphosphate; Alprostadil; Chemokine CX3CL1; Clopidogrel; Coronary Artery Disease; Humans; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Ticlopidine

2012
Spontaneous platelet aggregation in patients with acute coronary syndrome.
    Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:1

    Topics: Acute Coronary Syndrome; Alprostadil; Antibodies; Aspirin; Blood Platelets; Clopidogrel; Humans; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Ticlopidine; von Willebrand Factor

2013
Comparison of a new P2Y12 receptor specific platelet aggregation test with other laboratory methods in stroke patients on clopidogrel monotherapy.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Blood Platelets; Cell Adhesion Molecules; Clinical Laboratory Techniques; Clopidogrel; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Reproducibility of Results; Stroke; Ticlopidine

2013
'VASPFix' for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists.
    Thrombosis and haemostasis, 2014, Mar-03, Volume: 111, Issue:3

    Topics: Adenosine; Adenosine Diphosphate; Alprostadil; Biomarkers, Pharmacological; Blood Platelets; Bucladesine; Cell Adhesion Molecules; Cells, Cultured; Clopidogrel; Cyclic AMP; Humans; Iloprost; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Reproducibility of Results; Sensitivity and Specificity; Thiophenes; Thrombophilia; Ticlopidine

2014
Does the VerifyNow P2Y12 assay overestimate "therapeutic response" to clopidogrel? Insights using short thrombelastography.
    Thrombosis and haemostasis, 2014, Volume: 111, Issue:6

    Topics: Adenosine Diphosphate; Alprostadil; Clopidogrel; Drug Synergism; Humans; Platelet Aggregation; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombelastography; Ticlopidine

2014
Detection of clopidogrel resistance using ADP induced aggregometry with specific inhibitor PGE1.
    Clinical laboratory, 2014, Volume: 60, Issue:9

    Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Ticlopidine; Treatment Outcome

2014
Determinants of subacute response to clopidogrel: relative impact of CYP2C19 genotype and PGE1/adenylate cyclase signalling.
    Thrombosis research, 2015, Volume: 136, Issue:2

    Topics: Adenylyl Cyclases; Adult; Aged; Aged, 80 and over; Alprostadil; Clopidogrel; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Signal Transduction; Ticlopidine

2015
Effect of Drugs Associated With Bleeding Tendency on the Complications and Outcomes of Transforaminal Epidural Steroid Injection.
    Clinical spine surgery, 2017, Volume: 30, Issue:2

    Topics: Aged; alpha-Cyclodextrins; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Clopidogrel; Female; Follow-Up Studies; Hemorrhage; Humans; Injections, Epidural; Male; Middle Aged; Pain; Pain Measurement; Platelet Aggregation Inhibitors; Retrospective Studies; Steroids; Ticlopidine; Time Factors; Treatment Outcome

2017