Page last updated: 2024-08-16

ticlopidine and 2-oxo-clopidogrel

ticlopidine has been researched along with 2-oxo-clopidogrel in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (6.67)	29.6817
2010's	14 (93.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bouman, HJ; Taubert, D; van Werkum, JW	1
Farid, NA; Hagihara, K; Ikeda, T; Ishizuka, T; Kazui, M; Kurihara, A; Nishiya, Y; Okazaki, O	1
Abell, LM; Liu, EC	1
Hollenberg, PF; Lau, WC; Zhang, H	1
Zhou, J; Zhu, Y	1
Angiolillo, DJ; Brinda, BJ; Gawronski, BE; Markowitz, JS; Wang, X; Zhu, HJ	1
Chen, X; Gao, W; Jing, J; Li, N; Lu, Y; Parekha, HS; Qiu, Z; Ren, S; Song, L; Tian, F; Wang, X	1
El Rouby, N; Goldstein, JA; Johnson, JA; Langaee, TY; Markowitz, JS; Wang, X; Zhu, HJ	1
Boulenc, X; Djebli, N; Fabre, D; Fabre, G; Hurbin, F; Sultan, E	1
Markowitz, JS; Wang, X; Zhu, HJ	1
Chen, GM; Lu, J; Shao, H; Xu, YT; Zhan, Y; Zhang, HJ	1
Apostolovic, SR; Jankovic, SM; Jevtovic-Stoimenov, T; Konstantinovic, SS; Lilic, J; Nikolic, VN; Pavlovic, M; Stokanovic, D; Zivkovic, VS; Zvezdanovic, JB	1
Fu, ZH; Han, BS; Li, DY; Ren, YH; Song, YQ; Xue, Q; Yi, J; Zhou, CF	1
Court, MH; Lee, PM; Lyngby, JG	1
Apostolovic, S; Konstantinovic, SS; Lilic, J; Marinkovic, V; Nikolic, VN; Pavlovic, M; Stokanovic, D; Zvezdanovic, JB	1

Trials

2 trial(s) available for ticlopidine and 2-oxo-clopidogrel

Article	Year
Physiologically based pharmacokinetic modeling for sequential metabolism: effect of CYP2C19 genetic polymorphism on clopidogrel and clopidogrel active metabolite pharmacokinetics. Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:4 Topics: Adolescent; Adult; Aged; Amiodarone; Area Under Curve; Biotransformation; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Double-Blind Method; Dronedarone; Drug Interactions; Humans; Intestinal Absorption; Male; Middle Aged; Models, Biological; Polymorphism, Single Nucleotide; Reproducibility of Results; Secondary Metabolism; Ticlopidine; Tissue Distribution; Young Adult	2015
P-Glycoprotein Polymorphism C3435T Is Associated with Dose-Adjusted Clopidogrel and 2-Oxo-Clopidogrel Concentration. Pharmacology, 2016, Volume: 97, Issue:3-4 Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cross-Sectional Studies; Female; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine	2016

Article

Year

Physiologically based pharmacokinetic modeling for sequential metabolism: effect of CYP2C19 genetic polymorphism on clopidogrel and clopidogrel active metabolite pharmacokinetics.

Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:4

Topics: Adolescent; Adult; Aged; Amiodarone; Area Under Curve; Biotransformation; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Double-Blind Method; Dronedarone; Drug Interactions; Humans; Intestinal Absorption; Male; Middle Aged; Models, Biological; Polymorphism, Single Nucleotide; Reproducibility of Results; Secondary Metabolism; Ticlopidine; Tissue Distribution; Young Adult

2015

P-Glycoprotein Polymorphism C3435T Is Associated with Dose-Adjusted Clopidogrel and 2-Oxo-Clopidogrel Concentration.

Pharmacology, 2016, Volume: 97, Issue:3-4

Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Cross-Sectional Studies; Female; Genotype; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine

2016

Other Studies

13 other study(ies) available for ticlopidine and 2-oxo-clopidogrel

Article	Year
Cytochrome P-450 polymorphisms and response to clopidogrel. The New England journal of medicine, 2009, May-21, Volume: 360, Issue:21 Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Linkage Disequilibrium; Microsomes; Omeprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine	2009
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:1 Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Biotransformation; Cell Line; Cell Line, Tumor; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Humans; Ketoconazole; Kinetics; Mephenytoin; Microsomes; Microsomes, Liver; NADP; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Sulfaphenazole; Theophylline; Ticlopidine	2010
Dissecting the activation of thienopyridines by cytochromes P450 using a pharmacodynamic assay in vitro. The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:2 Topics: Aryl Hydrocarbon Hydroxylases; Baculoviridae; Biosensing Techniques; Biotransformation; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Assays; Humans; Microsomes; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet-Rich Plasma; Prasugrel Hydrochloride; Thienopyridines; Thiophenes; Ticlopidine	2011
Formation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomes. Molecular pharmacology, 2012, Volume: 82, Issue:2 Topics: Clopidogrel; Dose-Response Relationship, Drug; Glutathione; Humans; Microsomes, Liver; Oxidation-Reduction; Sulfhydryl Compounds; Ticlopidine	2012
In vitro biotransformation studies of 2-oxo-clopidogrel: multiple thiolactone ring-opening pathways further attenuate prodrug activation. Chemical research in toxicology, 2013, Jan-18, Volume: 26, Issue:1 Topics: Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dithiothreitol; Glutathione; Humans; Microsomes, Liver; Oxidation-Reduction; Oxygen Isotopes; Prodrugs; Recombinant Proteins; Sulfur; Tandem Mass Spectrometry; Ticlopidine; Water	2013
Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:3 Topics: Biotransformation; Carboxylic Ester Hydrolases; Cell Line; Clopidogrel; Humans; Hydrolysis; Liver; Nitrophenols; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine	2013
Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel. Pharmaceutical research, 2014, Volume: 31, Issue:1 Topics: Acetates; Animals; Clopidogrel; Esterases; Humans; Hydrolysis; Intestinal Mucosa; Microsomes; Phenylacetates; Prodrugs; Rats; Rats, Sprague-Dawley; Thiophenes; Ticlopidine	2014
The influence of the CYP2C1910 allele on clopidogrel activation and CYP2C192 genotyping. Pharmacogenetics and genomics, 2014, Volume: 24, Issue:8 Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Catalysis; Chromatography, Liquid; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Kinetics; Mephenytoin; Omeprazole; Pharmacogenetics; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Tandem Mass Spectrometry; Ticlopidine	2014
Carboxylesterase 1-mediated drug-drug interactions between clopidogrel and simvastatin. Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:2 Topics: Carboxylic Ester Hydrolases; Clopidogrel; Drug Interactions; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Simvastatin; Ticlopidine	2015
Metabolic Interaction Potential between Clopidogrel and Sulfonylurea Antidiabetic Agents: Effects on Clopidogrel Bioactivation. Pharmacology, 2016, Volume: 97, Issue:1-2 Topics: Carboxylic Ester Hydrolases; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9 Inhibitors; Dose-Response Relationship, Drug; Drug Antagonism; Gliclazide; Glipizide; Humans; Hypoglycemic Agents; Intestines; Liver; Microsomes; Sulfonylurea Compounds; Ticlopidine	2016
[Relationship between ATP-binding cassette subfamily B member 1 and cytochrome P450 2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with acute coronary syndrome]. Zhonghua xin xue guan bing za zhi, 2016, Apr-24, Volume: 44, Issue:4 Topics: Acute Coronary Syndrome; Alleles; Angina Pectoris; ATP Binding Cassette Transporter, Subfamily B; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Genotype; Hemorrhage; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Tandem Mass Spectrometry; Ticlopidine	2016
Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 2017, Volume: 19, Issue:4 Topics: Animals; Cats; Chromatography, High Pressure Liquid; Clopidogrel; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Ticlopidine	2017
The association of clopidogrel and 2-oxo-clopidogrel plasma levels and the 40 months clinical outcome after primary PCI. International journal of clinical pharmacy, 2018, Volume: 40, Issue:6 Topics: Acute Coronary Syndrome; Adult; Aged; Aged, 80 and over; Chest Pain; Clopidogrel; Coronary Artery Disease; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prognosis; ST Elevation Myocardial Infarction; Ticlopidine; Treatment Outcome	2018