tibolone has been researched along with 3-hydroxytibolone in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, RJ; Ebmeier, CC; Olin, JR; Wang, M | 1 |
| Delbressine, LP; Kloosterboer, HJ; Timmer, CJ; van Iersel, ML; Verheul, HA | 1 |
| Delbressine, LP; Kloosterboer, HJ; van Iersel, ML; Verheul, HA | 1 |
| Blok, LJ; Burger, CW; Hanifi-Moghaddam, P; Kloosterboer, HJ; Verheul, HA | 1 |
| Centrella, M; Hochberg, RB; Labaree, DC; McCarthy, TL | 1 |
| Barbier, C; Kaufman, DG; Kloosterboer, HJ | 1 |
| Kang, KW; Kim, YG | 1 |
| Bonfim, RR; César, IC; da Silva, EP; de Santana e Silva Cardoso, FF; de Souza Teixeira, L; de Souza, WC; Ferreira, DP; Gomes, SA; Lopes, AR; Mundim, IM; Pascoal, HD; Pianetti, GA | 1 |
2 trial(s) available for tibolone and 3-hydroxytibolone
| Article | Year |
|---|---|
Levels of tibolone and estradiol and their nonsulfated and sulfated metabolites in serum, myometrium, and vagina of postmenopausal women following treatment for 21 days with tibolone, estradiol, or estradiol plus medroxyprogestrone acetate.
Topics: Aged; Estradiol; Estrone; Female; Humans; Medroxyprogesterone Acetate; Middle Aged; Myometrium; Norpregnenes; Postmenopause; Selective Estrogen Receptor Modulators; Tissue Distribution; Uterine Prolapse; Vagina | 2007 |
Bioequivalence studies of tibolone in premenopausal women and effects on expression of the tibolone-metabolizing enzyme AKR1C (aldo-keto reductase) family caused by estradiol.
Topics: 20-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Adult; Alcohol Oxidoreductases; Aldehyde Reductase; Aldo-Keto Reductase Family 1 Member C3; Aldo-Keto Reductases; Area Under Curve; Cell Line, Tumor; Cross-Over Studies; Enzyme Activation; Estradiol; Estrogen Receptor Modulators; Female; Gene Expression Regulation, Enzymologic; Glucose Transporter Type 1; Half-Life; Humans; Hydroxyprostaglandin Dehydrogenases; Hydroxysteroid Dehydrogenases; Immunoblotting; Norpregnenes; Premenopause; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Therapeutic Equivalency; Young Adult | 2008 |
6 other study(ies) available for tibolone and 3-hydroxytibolone
| Article | Year |
|---|---|
Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs).
Topics: Chromatography, High Pressure Liquid; Gene Expression Profiling; Humans; Intestine, Small; Liver; Nitrophenols; Norpregnenes; Phosphoadenosine Phosphosulfate; Postmenopause; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Chloride; Sulfotransferases; Temperature | 2006 |
Pharmacokinetic parameters of tibolone and metabolites in plasma, urine, feces, and bile from ovariectomized cynomolgus monkeys after a single dose or multiple doses of tibolone.
Topics: Administration, Oral; Animals; Bile; Biotransformation; Chromatography, High Pressure Liquid; Drug Administration Schedule; Feces; Female; Gas Chromatography-Mass Spectrometry; Macaca fascicularis; Norpregnenes; Ovariectomy; Reproducibility of Results; Selective Estrogen Receptor Modulators; Sulfates; Tandem Mass Spectrometry | 2007 |
Selective tissue distribution of tibolone metabolites in mature ovariectomized female cynomolgus monkeys after multiple doses of tibolone.
Topics: Administration, Oral; Animals; Biotransformation; Brain; Breast; Chromatography, High Pressure Liquid; Drug Administration Schedule; Female; Gas Chromatography-Mass Spectrometry; Macaca fascicularis; Molecular Structure; Norpregnenes; Ovariectomy; Reproducibility of Results; Selective Estrogen Receptor Modulators; Sulfates; Tandem Mass Spectrometry; Tissue Distribution; Uterus; Vagina | 2007 |
3-ketosteroid reductase activity and expression by fetal rat osteoblasts.
Topics: 3-Hydroxysteroid Dehydrogenases; Androgen Receptor Antagonists; Animals; CCAAT-Enhancer-Binding Protein-delta; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Dinoprostone; Estrogen Receptor alpha; Gene Expression Regulation, Enzymologic; Gonadal Steroid Hormones; Norpregnenes; Oligodeoxyribonucleotides, Antisense; Osteoblasts; Oxidoreductases; Rats; Receptors, Androgen; Response Elements; Smad Proteins; Transforming Growth Factor beta | 2007 |
Effects of tibolone metabolites on human endometrial cell lines in co-culture.
Topics: 20-Hydroxysteroid Dehydrogenases; Cell Division; Cell Line; Coculture Techniques; Endometrium; Epithelial Cells; Estradiol; Estrogen Receptor Modulators; Female; Humans; Norpregnenes; Pregnenediones; Reverse Transcriptase Polymerase Chain Reaction; Stromal Cells | 2008 |
Determination of 3-α-hydroxytibolone in human plasma by LC-MS/MS: application for a pharmacokinetic study after administration of a tibolone formulation.
Topics: Administration, Oral; Chromatography, Liquid; Estrogen Receptor Modulators; Female; Humans; Limit of Detection; Norpregnenes; Tandem Mass Spectrometry | 2013 |