tiazofurin and 3-deazaguanosine

tiazofurin has been researched along with 3-deazaguanosine* in 2 studies

Reviews

1 review(s) available for tiazofurin and 3-deazaguanosine

ArticleYear
Metabolism and action of purine nucleoside analogs.
    Pharmacology & therapeutics, 1991, Volume: 49, Issue:3

    Recent investigations have identified many new purine nucleoside analogs that act as antimetabolites. This article focuses on the metabolism and mechanisms of action of tiazofurin, 3-deazaguanosine, neplanocin A, arabinosyladenine in combination with inhibitors of adenosine deaminase, arabinosyl-2-fluoroadenine, and 2-chloro-2'-deoxyadenosine, drugs that are either currently being evaluated in clinical trials or are close to that stage. The diverse metabolic requirements for activation, unique mechanisms of action, and differential biological activities of these compounds are characterized and evaluated for prospective therapeutic application.

    Topics: 2-Chloroadenosine; Adenosine; Cladribine; Deoxyadenosines; Guanine; Guanosine; Humans; Purine Nucleosides; Ribavirin; Vidarabine

1991

Other Studies

1 other study(ies) available for tiazofurin and 3-deazaguanosine

ArticleYear
Novel nucleoside inhibitors of guanosine metabolism as antitumor agents.
    Advances in enzyme regulation, 1984, Volume: 22

    A detailed study of the inhibition of DR and TR in the SkLu-1 line of human lung adenocarcinoma has shown that TR significantly inhibits this tumor line, probably via inhibition of IMP dehydrogenase by the corresponding TAD analog of NAD. DR exhibited a similar degree of inhibition in this cell line. In a system devised to detect the inhibition of cloning efficiency of the SkLu cells, DR showed a 50% inhibition at 4 X 10(-3) M and TR at 1 X 10(-4) M. When DR and TR were used in combination, the ID50 was decreased to 3 X 10(-5) M. The study of DR in a number of human carcinoma cell lines revealed that de novo purine biosynthesis was significantly inhibited; however, in the SkLu-1 lung carcinoma cells this inhibition was not observed. The synergism observed in this cell line is presently viewed as potentially due to both agents acting on IMP dehydrogenase at different sites.

    Topics: Adenocarcinoma; Antineoplastic Agents; Cell Division; Cell Line; Clone Cells; Drug Synergism; Formates; Guanosine; Humans; Lung Neoplasms; Purines; Ribavirin; Ribonucleosides

1984