tiamulin has been researched along with tetramethylpyrazine* in 1 studies
1 other study(ies) available for tiamulin and tetramethylpyrazine
| Article | Year |
|---|---|
[Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo].
To study the pharmacokinetics of single administration and different compatibility of tetramethylpyrazine (TMP) in rats.. Thirty two Sprague-Dawley rats were randomly divided into 4 groups: the TMP (30 mg x kg(-1)) group, the TMP+FA (30 mg x kg(-1) + 50 mg x kg(-1)) group, the TMP+TET (30 mg x kg(-1) mg x kg(-1)) group and the TMP+FA+TET (30 mg x kg(-1) + 50 mg x kg(-1) + 20 mg x kg(-1)) group. After the oral administration, their blood samples were collected to detect plasmas concentrations by HPLC method and to calculate pharmacokinetic parameters DAS 2.0 program.. In compatibility with FA, AUC(0-t), Cmax and Tmax showed no significant difference with the single administration of TMP, but t(1/2) and MRT,, were obviously longer than the single administration. In compatibility with TET and FA + TET, AUC (0-t), Cmax and Tmax showed significant increase than the single administration of TMP, whereas t(1/2) and MRT0, did not notably vary from the single administration.. FA can prolong TMP's action time in rats, and TET can accelerate TMP's absorption in rats. Topics: Animals; Chromatography, High Pressure Liquid; Coumaric Acids; Diterpenes; Drug Interactions; Female; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley | 2012 |