tiamulin and tedizolid

tiamulin has been researched along with tedizolid* in 1 studies

Other Studies

1 other study(ies) available for tiamulin and tedizolid

Article	Year
Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12 Following recent reports of ribosomal protein L3 mutations in laboratory-derived linezolid-resistant (LZD(r)) Staphylococcus aureus, we investigated whether similar mutations were present in LZD(r) staphylococci of clinical origin. Sequence analysis of a variety of LZD(r) isolates revealed two L3 mutations, DeltaSer145 (S. aureus NRS127) and Ala157Arg (Staphylococcus epidermidis 1653059), both occurring proximal to the oxazolidinone binding site in the peptidyl transferase center. The oxazolidinone torezolid maintained a >or=8-fold potency advantage over linezolid for both strains. Topics: Acetamides; Binding Sites; Drug Resistance, Bacterial; Linezolid; Mutation; Oxazolidinones; Protein Structure, Secondary; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Tetrazoles	2009

Article

Year

Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.

Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:12

Following recent reports of ribosomal protein L3 mutations in laboratory-derived linezolid-resistant (LZD(r)) Staphylococcus aureus, we investigated whether similar mutations were present in LZD(r) staphylococci of clinical origin. Sequence analysis of a variety of LZD(r) isolates revealed two L3 mutations, DeltaSer145 (S. aureus NRS127) and Ala157Arg (Staphylococcus epidermidis 1653059), both occurring proximal to the oxazolidinone binding site in the peptidyl transferase center. The oxazolidinone torezolid maintained a >or=8-fold potency advantage over linezolid for both strains.

Topics: Acetamides; Binding Sites; Drug Resistance, Bacterial; Linezolid; Mutation; Oxazolidinones; Protein Structure, Secondary; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Tetrazoles

2009