tiagabine has been researched along with vigabatrin in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 28 (40.58) | 18.2507 |
| 2000's | 34 (49.28) | 29.6817 |
| 2010's | 6 (8.70) | 24.3611 |
| 2020's | 1 (1.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Beran, RG | 2 |
| Brodie, MJ; Leach, JP | 1 |
| Patsalos, PN; Sander, JW | 1 |
| Harden, CL | 1 |
| Ramsay, RE; Slater, JD | 1 |
| Bialer, M | 1 |
| Brodie, MJ; Butler, E; Carswell, A; Leach, JP; Majid, A; Sills, GJ; Thompson, GG | 1 |
| Chadwick, DW; Kadir, ZA; Marson, AG | 1 |
| Meldrum, BS | 1 |
| Gram, L | 1 |
| Brodie, MJ; Wilson, EA | 1 |
| Shorvon, S; Stefan, H | 1 |
| Hosford, DA; Wang, Y | 1 |
| Brodie, MJ; Butler, E; Forrest, G; Leach, JP; Sills, GJ; Thompson, GG | 1 |
| Dalby, NO; Nielsen, EB | 1 |
| Pellock, JM | 3 |
| Bazil, CW; Pedley, TA | 1 |
| Anderson, GD | 1 |
| Leppik, IE | 1 |
| Bourgeois, BF | 1 |
| Ladurner, G; Löscher, W; Moroder, T; Nagler, M; Staffen, W; Trinka, E | 1 |
| Ben-Menachem, E; Cramer, JA; Fisher, R; French, J; Mattson, RH | 1 |
| Eckstein-Ludwig, U; Fei, J; Schwarz, W | 1 |
| Appleton, R; Pellock, JM | 1 |
| White, HS | 1 |
| Brodie, MJ; Butler, E; Sills, GJ; Thompson, GG | 1 |
| Crawford, PM; Datta, PK | 1 |
| Czuczwar, SJ | 1 |
| Vajda, FJ | 1 |
| Betts, T; Crawford, PM; Rüsch, N; Trimble, MR | 1 |
| Brodie, MJ; Butler, E; Duncan, R; Fraser, CM; Howatson, A; Lindsay, K; Sills, GJ; Thompson, GG | 1 |
| Bingmann, D; Bonnet, U; Hufnagel, A; Leniger, T; Wiemann, M | 1 |
| Foletti, GB | 1 |
| Johannessen, SI; Nakken, KO; Rytter, E | 1 |
| Bachański, M; Jóźwiak, S; Karkowska, B; Kmieć, T; Kuczyński, D | 1 |
| Aldenkamp, AP | 1 |
| Brodie, MJ; Butler, E; Forrest, G; Patsalos, PN; Ratnaraj, N; Sills, GJ | 1 |
| Brodie, MJ | 1 |
| Boon, PA; van Rijckevorsel, K | 1 |
| Köhling, R; König, K; Lücke, A; Mayer, T; Speckmann, EJ; Wolf, P | 1 |
| Lawden, MC | 1 |
| Johnson, MA; Krauss, GL; Miller, NR; Sheth, S | 1 |
| Angehagen, M; Ben-Menachem, E; Hansson, E; Rönnbäck, L | 1 |
| Bergin, AM; Connolly, M | 1 |
| Sills, GJ | 1 |
| Rupprecht, R; Zwanzger, P | 2 |
| Johannessen, SI; Perucca, E | 1 |
| Bernardi, G; Calabresi, P; Costa, C; Leone, G; Pisani, F; Saulle, E | 1 |
| Gau, CS; Lin, CJ; Liou, HH; Shyu, MK; Wu, SP | 1 |
| Benz, AM; Ishikawa, M; Izumi, M; Izumi, Y; Thio, LL; Zorumski, CF | 1 |
| Fueta, Y; Kunugita, N; Schwarz, W | 1 |
| Caccamo, D; Calabresi, P; Costa, C; Gorgone, G; Ientile, R; Mazzon, E; Oteri, G; Pisani, F | 1 |
| Filip, M; Frankowska, M; Gołda, A; Przegaliński, E; Vetulani, J; Zaniewska, M | 2 |
| Johannessen, SI; Tomson, T | 1 |
| Czuczwar, SJ; Luszczki, JJ | 1 |
| Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M | 1 |
| Ali, F; Cavanna, AE; McCorry, D; Rickards, HE | 1 |
| Cull-Candy, SG; Dupree, JL; Edwards, J; Farrant, M; Gallo, V; Harvey, L; Hübner, CA; Li, P; McEllin, B; Scafidi, J; Sun, D; Zonouzi, M | 1 |
| Abdel-Galil, AG; El-Gowilly, SM; El-Mas, MM; Sallam, MY | 1 |
| Battino, D; Bromley, R; Kochen, S; Meador, KJ; Pennell, PB; Thomas, SV; Tomson, T | 1 |
32 review(s) available for tiagabine and vigabatrin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Newer antiepileptic drugs. Towards an improved risk-benefit ratio.
Topics: Acetamides; Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Piracetam; Propylene Glycols; Risk Factors; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 1994 |
New antiepileptic drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Triazines; Vigabatrin | 1994 |
Antiepileptic drugs in clinical development.
Topics: Acetates; Amines; Aminocaproates; Anticonvulsants; Brain; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Structure-Activity Relationship; Synaptic Transmission; Tiagabine; Topiramate; Triazines; Vigabatrin | 1993 |
Comparative pharmacokinetics of the newer antiepileptic drugs.
Topics: Acetamides; Acetates; Amines; Aminocaproates; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dioxolanes; Felbamate; Flunarizine; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1993 |
New antiepileptic drugs: a systematic review of their efficacy and tolerability.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Child; Cross-Over Studies; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Male; Middle Aged; Nipecotic Acids; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 1996 |
Update on the mechanism of action of antiepileptic drugs.
Topics: 4-Aminobutyrate Transaminase; Acetamides; Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channels; Lamotrigine; Membrane Potentials; Mice; Neurotransmitter Agents; Nipecotic Acids; Phenethylamines; Phenylcarbamates; Propylene Glycols; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tiagabine; Topiramate; Triazines; Vigabatrin | 1996 |
Pharmacokinetics of new antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Carbamazepine; Cyclohexanecarboxylic Acids; Enzyme Induction; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Humans; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1996 |
New antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1996 |
Overview of the safety of newer antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1997 |
Overview of lamotrigine and the new antiepileptic drugs: the challenge.
Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Exanthema; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Treatment Outcome; Triazines; Valproic Acid; Vigabatrin | 1997 |
Advances in the medical treatment of epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approval; Drug Design; Drug Interactions; Drug Resistance; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Ketones; Lamotrigine; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Phenylcarbamates; Phenytoin; Prodrugs; Propylene Glycols; Tiagabine; Topiramate; Triazines; United States; Valproic Acid; Vigabatrin | 1998 |
A mechanistic approach to antiepileptic drug interactions.
Topics: Acetates; Amines; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cyclohexanecarboxylic Acids; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Glucuronosyltransferase; Humans; Lamotrigine; Mixed Function Oxygenases; Nipecotic Acids; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Tiagabine; Topiramate; Triazines; Valproic Acid; Vigabatrin | 1998 |
Role of new and established antiepileptic drugs.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Epilepsies, Partial; Epilepsy; Felbamate; Fructose; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Teratogens; Tiagabine; Topiramate; Triazines; Vigabatrin | 1998 |
New antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Approval; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; United States; Vigabatrin | 1998 |
Clinical and EEG findings in complex partial status epilepticus with tiagabine.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Epilepsy, Complex Partial; Female; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Tiagabine; Vigabatrin | 1999 |
New antiepileptic drugs: comparison of key clinical trials.
Topics: Acetates; Amines; Anticonvulsants; Controlled Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind Method; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Placebos; Research Design; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin | 1999 |
Use of new antiepileptic drugs in the treatment of childhood epilepsy.
Topics: Acetates; Adult; Age Factors; Amines; Anticonvulsants; Child; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Spasms, Infantile; Tiagabine; Topiramate; Triazines; Vigabatrin | 1999 |
Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Partial; Felbamate; Fructose; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Receptors, GABA; Sodium Channels; Synaptic Transmission; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 1999 |
Managing pediatric epilepsy syndromes with new antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1999 |
[GABA-ergic system and antiepileptic drugs].
Topics: Acetates; Amines; Anticonvulsants; Binding, Competitive; Calcium Channels; Chloride Channels; Cyclohexanecarboxylic Acids; Epilepsy; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Humans; Nipecotic Acids; Receptors, GABA; Sodium Channels; Tiagabine; Vigabatrin | 2000 |
New antiepileptic drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2000 |
[Adverse effects of antiepileptic agents].
Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Clobazam; Cyclohexanecarboxylic Acids; Drug Utilization; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Norway; Piracetam; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2000 |
Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate.
Topics: Anticonvulsants; Fructose; Neuroprotective Agents; Nipecotic Acids; Seizures; Tiagabine; Topiramate; Vigabatrin | 2003 |
New antiepileptic drug therapies.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Phenytoin; Piracetam; Propylene Glycols; Thiazines; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2002 |
Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine.
Topics: Animals; Anticonvulsants; GABA Agonists; Humans; Nipecotic Acids; Receptors, GABA; Seizures; Tiagabine; Vigabatrin; Visual Fields | 2003 |
[Significance of GABAA receptors for the pathophysiology and therapy of panic disorders].
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Cognitive Behavioral Therapy; Combined Modality Therapy; Humans; Mice; Mice, Knockout; Nipecotic Acids; Panic Disorder; Receptors, GABA-A; Steroids; Tiagabine; Vigabatrin | 2003 |
The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2003 |
Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Monitoring; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Pregabalin; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2006 |
New pharmacotherapies for pediatric seizures.
Topics: Adolescent; Amines; Animals; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Pediatrics; Piracetam; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 2004 |
Behavioral and cognitive effects of anti-epileptic drugs.
Topics: Amines; Anticonvulsants; Antidepressive Agents; Behavior; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Lamotrigine; Neurotransmitter Agents; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Triazines; Vigabatrin | 2010 |
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Everolimus; Felbamate; Female; Fenfluramine; Gabapentin; Humans; Infant; Lacosamide; Lamotrigine; Levetiracetam; Oxcarbazepine; Phenobarbital; Phenytoin; Prospective Studies; Tiagabine; Topiramate; Valproic Acid; Vigabatrin; Zonisamide | 2022 |
2 trial(s) available for tiagabine and vigabatrin
| Article | Year |
|---|---|
[Gabitril as an additive drug in therapy of intractable epileptic seizures in children].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy, Generalized; Felbamate; Female; Follow-Up Studies; Humans; Lamotrigine; Male; Nipecotic Acids; Nitrazepam; Oxcarbazepine; Phenylcarbamates; Phenytoin; Propylene Glycols; Tiagabine; Triazines; Valproic Acid; Vigabatrin | 2000 |
A controlled study comparing visual function in patients treated with vigabatrin and tiagabine.
Topics: Adult; Aged; Anticonvulsants; Cross-Sectional Studies; Electroretinography; Epilepsy; Female; Humans; Male; Middle Aged; Nipecotic Acids; Tiagabine; Vigabatrin; Visual Acuity; Visual Fields | 2003 |
35 other study(ies) available for tiagabine and vigabatrin
| Article | Year |
|---|---|
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |
New antiepileptic medications.
Topics: 4-Aminobutyrate Transaminase; Acetamides; Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Tiagabine; Triazines; Vigabatrin | 1995 |
Synergism with GABAergic drugs in refractory epilepsy.
Topics: 4-Aminobutyrate Transaminase; Adult; Drug Synergism; Epilepsy; Female; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Nipecotic Acids; Tiagabine; Vigabatrin | 1994 |
Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes.
Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Tiagabine; Vigabatrin | 1996 |
Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin, and topiramate against human absence seizures.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Absence; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Mice; Nipecotic Acids; Tiagabine; Topiramate; Triazines; Vigabatrin | 1997 |
Neurochemical actions of vigabatrin and tiagabine alone and in combination in mouse cortex.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mice; Mice, Inbred ICR; Nipecotic Acids; Tiagabine; Vigabatrin | 1997 |
Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Gabapentin; gamma-Aminobutyric Acid; Lamotrigine; Male; Mice; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Tiagabine; Triazines; Vigabatrin | 1997 |
Inhibition of uptake, steady-state currents, and transient charge movements generated by the neuronal GABA transporter by various anticonvulsant drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Binding Sites; Biological Transport; Carrier Proteins; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Electric Conductivity; Female; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Mice; Nipecotic Acids; Oocytes; Organic Anion Transporters; Patch-Clamp Techniques; Tiagabine; Valproic Acid; Vigabatrin; Xenopus laevis | 1999 |
Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Evaluation Studies as Topic; Male; Mice; Mice, Inbred Strains; Nipecotic Acids; Tiagabine; Vigabatrin | 1999 |
Refractory epilepsy: treatment with new antiepileptic drugs.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Resistance; Drug Therapy, Combination; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Middle Aged; Nipecotic Acids; Patient Dropouts; Retrospective Studies; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin | 2000 |
Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables.
Topics: Adolescent; Adult; Anticonvulsants; Dominance, Cerebral; Dose-Response Relationship, Drug; Epilepsy; Female; Fructose; Humans; Male; Middle Aged; Mood Disorders; Nipecotic Acids; Psychoses, Substance-Induced; Recurrence; Retrospective Studies; Tiagabine; Topiramate; United Kingdom; Vigabatrin | 2000 |
Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue.
Topics: Adult; Anticonvulsants; Astrocytes; Carrier Proteins; Cells, Cultured; Female; Fetus; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Membrane Proteins; Membrane Transport Proteins; Neural Inhibition; Nipecotic Acids; Organic Anion Transporters; Pregnancy; Pregnancy Trimester, Second; Temporal Lobe; Tiagabine; Valproic Acid; Vigabatrin | 1999 |
Different effects of GABAergic anticonvulsants on 4-aminopyridine-induced spontaneous GABAergic hyperpolarizations of hippocampal pyramidal cells--implication for their potency in migraine therapy.
Topics: 4-Aminopyridine; Acetates; Amines; Analgesics; Animals; Anticonvulsants; Convulsants; Cyclohexanecarboxylic Acids; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Humans; Membrane Potentials; Migraine Disorders; Nipecotic Acids; Pyramidal Cells; Tiagabine; Time Factors; Valproic Acid; Vigabatrin | 2000 |
[Clinical utilization of new anti-epileptic agents].
Topics: Acetates; Amines; Anemia, Aplastic; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Drug Tolerance; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Visual Fields | 2000 |
Effects of antiepileptic drugs on cognition.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; Triazoles; Vigabatrin | 2001 |
Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina.
Topics: Animals; Anticonvulsants; Male; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Retina; Tiagabine; Vigabatrin; Vision Disorders; Visual Fields | 2001 |
Management strategies for refractory localization-related seizures.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Practice Patterns, Physicians'; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin | 2001 |
Ethical dilemmas of potential adverse events.
Topics: Anticonvulsants; Epilepsy; Ethics, Medical; GABA Agonists; Humans; Informed Consent; Liability, Legal; Nipecotic Acids; Tiagabine; Vigabatrin; Vision Disorders | 2001 |
The 'number needed to treat' with levetiracetam (LEV): comparison with the other new antiepileptic drugs (AEDs).
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2002 |
Pre- rather than co-application of vigabatrin increases the efficacy of tiagabine in hippocampal slices.
Topics: Animals; Anticonvulsants; Culture Techniques; Drug Synergism; Evoked Potentials; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Kindling, Neurologic; Magnesium; Nipecotic Acids; Premedication; Tiagabine; Vigabatrin | 2002 |
Vigabatrin, tiagabine, and visual fields.
Topics: Anticonvulsants; Epilepsy; Humans; Nipecotic Acids; Retina; Tiagabine; Time Factors; Vigabatrin; Visual Fields | 2003 |
Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain Ischemia; Carrier Proteins; Cerebral Cortex; Corpus Striatum; Electric Stimulation; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission; Tiagabine; Vigabatrin | 2004 |
Interaction between anticonvulsants and human placental carnitine transporter.
Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techniques; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Models, Biological; Nipecotic Acids; Organic Cation Transport Proteins; Phenytoin; Placenta; Pregnancy; Pregnancy Complications; Pregnancy Proteins; Solute Carrier Family 22 Member 5; Tiagabine; Topiramate; Triazines; Valproic Acid; Vigabatrin | 2004 |
Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.
Topics: Acute Disease; Animals; Anticonvulsants; Darkness; gamma-Aminobutyric Acid; Light; Male; Nipecotic Acids; Photic Stimulation; Photoreceptor Cells; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Scotoma; Tiagabine; Vigabatrin; Vision Disorders; Visual Fields | 2004 |
Vigabatrin and tiagabine might have antipanic properties.
Topics: Anti-Anxiety Agents; Anticonvulsants; Anxiety Disorders; Clinical Trials as Topic; Humans; Nipecotic Acids; Tiagabine; Vigabatrin | 2004 |
Antiepileptic action induced by a combination of vigabatrin and tiagabine.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Electric Stimulation; Evoked Potentials; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Magnesium; Mice; Nipecotic Acids; Oocytes; Patch-Clamp Techniques; Potassium Chloride; Seizures; Tiagabine; Time Factors; Vigabatrin; Xenopus laevis | 2005 |
Tiagabine and vigabatrin reduce the severity of NMDA-induced excitotoxicity in chick retina.
Topics: Analysis of Variance; Animals; Chick Embryo; Drug Interactions; Excitatory Amino Acid Agonists; L-Lactate Dehydrogenase; N-Methylaspartate; Neuroprotective Agents; Nipecotic Acids; Retina; Tiagabine; Vigabatrin | 2006 |
Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization.
Topics: Amines; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Cyclohexanecarboxylic Acids; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agents; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Male; Motor Activity; Nipecotic Acids; Rats; Rats, Wistar; Tiagabine; Vigabatrin | 2006 |
Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Epilepsy; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Reaction Time; Statistics as Topic; Tiagabine; Vigabatrin | 2007 |
Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats.
Topics: Amines; Animals; Behavior, Animal; Cocaine; Cyclohexanecarboxylic Acids; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Male; Nipecotic Acids; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration; Tiagabine; Vigabatrin | 2007 |
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Interactions; Drug Synergism; Gabapentin; gamma-Aminobutyric Acid; Levetiracetam; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Piracetam; Seizures; Tiagabine; Tissue Distribution; Vigabatrin | 2009 |
GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury.
Topics: Action Potentials; Animals; Animals, Newborn; Asphyxia Neonatorum; Carbachol; Cell Count; Cells, Cultured; Cerebellum; Demyelinating Diseases; Disease Models, Animal; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypoxia, Brain; Interneurons; Male; Mice; Mice, Knockout; Mice, Transgenic; Neural Stem Cells; Neurogenesis; Nipecotic Acids; Oligodendroglia; Purkinje Cells; Receptors, GABA-A; Solute Carrier Family 12, Member 2; Tiagabine; Vigabatrin; White Matter | 2015 |
Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats.
Topics: Animals; Arterial Pressure; Baclofen; Bicuculline; Endotoxemia; GABA Agents; Heart Rate; Interleukin-6; Lipopolysaccharides; Male; Nipecotic Acids; Nitric Oxide; Rats, Wistar; Receptors, GABA-A; Tiagabine; Tumor Necrosis Factor-alpha; Vigabatrin | 2016 |