tiagabine has been researched along with pentylenetetrazole in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 10 (62.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Fink-Jensen, A; Hansen, L; Judge, ME; Nielsen, PG; Suzdak, PD; Swedberg, MD | 1 |
| Andersen, KE; Frederiksen, K; Knutsen, LJ; Nielsen, EB; Suzdak, PD; Sørensen, PO | 1 |
| Browne, SE; Pertwee, RG; Ross, TM; Stretton, CD | 1 |
| Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD | 1 |
| Dalby, NO | 1 |
| Haugvicová, R; Kubová, H; Mares, P; Skutová, M; Suchomelová, L | 1 |
| Czuczwar, SJ; Luszczki, JJ | 3 |
| Bolvig, T; Clausen, RP; Falch, E; Frølund, B; Hansen, SL; Krogsgaard-Larsen, P; Larsson, OM; Perregaard, J; Petersen, G; Sarup, A; Schousboe, A; Slough, S; Watson, WP; White, HS | 1 |
| Dhir, A; Kulkarni, SK | 1 |
| Luszczki, JJ | 1 |
| Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M | 1 |
| Krzyzanowski, M; Luszczki, JJ; Swiader, MJ | 1 |
| Clausen, RP; Danbolt, NC; Guo, C; Holen, T; Holmseth, S; Hua, R; Laake, P; Lehre, AC; Madsen, KK; Olofsson, AM; Poblete-Naredo, I; Rowley, NM; Rusakov, DA; Schousboe, A; White, HS; Zhou, Y | 1 |
| Ahmad, T; Alasmari, AF; Alasmari, F; Alqahtani, F; Alqarni, SA; Anjum, SMM; Ashraf, W; Imran, I; Javaid, S; Rasool, MF | 1 |
16 other study(ies) available for tiagabine and pentylenetetrazole
| Article | Year |
|---|---|
The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.
Topics: Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Globus Pallidus; Male; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra; Tiagabine | 1992 |
NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.
Topics: Animals; Anticonvulsants; Astrocytes; Behavior, Animal; Brain; Carbolines; Cells, Cultured; Convulsants; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Neurons; Nicotinic Acids; Nipecotic Acids; Oximes; Pentylenetetrazole; Rats; Seizures; Synaptosomes; Tiagabine | 1992 |
An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol.
Topics: Amino Acids; Amino Acids, Neutral; Analgesics; Animals; Anticonvulsants; Body Temperature; Cannabidiol; Dronabinol; Electric Stimulation; Flurazepam; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Nipecotic Acids; Pentylenetetrazole; Seizures; Tiagabine | 1991 |
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred DBA; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Tiagabine | 1991 |
GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.
Topics: Acoustic Stimulation; Anesthesia; Animals; Anisoles; Anticonvulsants; Carbazoles; Chromatography, High Pressure Liquid; Convulsants; Electroshock; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Mice; Mice, Inbred DBA; Microdialysis; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Pentylenetetrazole; Piperidines; Seizures; Substantia Nigra; Thalamus; Tiagabine | 2000 |
Two different anticonvulsant actions of tiagabine in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Tiagabine | 2000 |
Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study.
Topics: Amines; Animals; Anticonvulsants; Convulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Seizures; Tiagabine | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Cloning, Molecular; Convulsants; Drug Synergism; Epilepsy; Epilepsy, Reflex; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; N-Acetylglucosaminyltransferases; Neurons; Nipecotic Acids; Pentylenetetrazole; Pilocarpine; Psychomotor Disorders; Recombinant Proteins; Seizures; Tiagabine | 2005 |
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Nipecotic Acids; Oxcarbazepine; Pentylenetetrazole; Seizures; Tiagabine | 2005 |
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2 Inhibitors; Drug Synergism; Drug Therapy, Combination; Lactones; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Seizures; Sulfones; Tiagabine | 2006 |
Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Epilepsy; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Reaction Time; Statistics as Topic; Tiagabine; Vigabatrin | 2007 |
Interactions of tiagabine with ethosuximide in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Brain; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Ethosuximide; Fluorescence Polarization Immunoassay; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Seizures; Tiagabine; Tissue Distribution | 2008 |
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Interactions; Drug Synergism; Gabapentin; gamma-Aminobutyric Acid; Levetiracetam; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Piracetam; Seizures; Tiagabine; Tissue Distribution; Vigabatrin | 2009 |
Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Random Allocation; Seizures; Tiagabine; Valproic Acid | 2009 |
Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice.
Topics: Animals; Anticonvulsants; Convulsants; Crosses, Genetic; Dose-Response Relationship, Drug; Electroshock; Exons; Female; GABA Plasma Membrane Transport Proteins; Isoxazoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nipecotic Acids; Pentylenetetrazole; RNA, Messenger; Seizures; Tiagabine | 2011 |
Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers.
Topics: Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Cognition; Epilepsy; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; RNA, Messenger; Seizures; Tiagabine | 2023 |