tiagabine has been researched along with nipecotic acid in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Borden, LA; Branchek, TA; Dhar, TG; Gluchowski, C; Smith, KE; Tyagarajan, S; Weinshank, RL | 1 |
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Höfner, G; Kragler, A; Wanner, KT | 1 |
| Faust, MR; Höfner, G; Pabel, J; Wanner, KT | 1 |
| Lutz, TA; Petrera, M; Sindelar, M; Wanner, KT | 1 |
| Höfner, G; Quandt, G; Wanner, KT | 1 |
| Hellenbrand, T; Höfner, G; Wanner, KT; Wein, T | 1 |
| Kern, F; Wanner, KT | 1 |
| Lambert, JD; Roepstorff, A | 1 |
| Chapman, AG; Meldrum, BS; Parvez, NS; Smith, SE | 1 |
| Andersen, KE; Braestrup, C; Grønwald, FC; Jørgensen, AS; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD; Sørensen, PO | 1 |
| Draguhn, A; Heinemann, U; Meierkord, H; Pfeiffer, M | 1 |
| Egebjerg, J; Sørensen, PO; Thomsen, C | 1 |
| Scholze, P; Singer, EA; Sitte, HH | 1 |
| Kreil, A; Richter, A | 1 |
| Fang, K; Lin, G; Liu, X; Zhang, J; Zhang, P | 1 |
| Bräuner-Osborne, H; Jørgensen, FS; Skovstrup, S; Taboureau, O | 1 |
| David, L; Jørgensen, FS; Skovstrup, S; Taboureau, O | 1 |
| Akhtar, MJ; Bhatia, R; Kumar, B; Kumar, P; Mehta, V; Singh, K | 1 |
| Dörnyei, G; Gács-Baitz, E; Héja, L; Incze, M; Kardos, J; Kovács, I; Peredy-Kajtár, M; Szántay, C; Szárics, E; Temesváriné-Major, E | 1 |
| Guo, L; Jiang, H; Lin, G; Luo, X; Wen, R; Xu, L; Zhang, J; Zheng, J | 1 |
| Borkar, N; Clausen, RP; Jørgensen, L; Krogsgaard-Larsen, P; Madsen, KK; Schousboe, A; Skovgaard-Petersen, J; Vogensen, SB; Wellendorph, P; White, HS | 1 |
| Dine, J; Eder, M; Höfner, G; Lutz, T; Pabel, J; Wanner, KT; Wein, T | 1 |
1 review(s) available for tiagabine and nipecotic acid
| Article | Year |
|---|---|
Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies.
Topics: Anticonvulsants; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Tiagabine | 2022 |
22 other study(ies) available for tiagabine and nipecotic acid
| Article | Year |
|---|---|
Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3.
Topics: Animals; Binding Sites; Biological Transport; Blood-Brain Barrier; Carrier Proteins; Cell Line; Cloning, Molecular; Drug Design; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Ligands; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Proline; Rats | 1994 |
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.
Topics: Animals; Benzylamines; Cell Line; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Methylation; Mice; Molecular Structure; Structure-Activity Relationship | 2008 |
Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.
Topics: Animals; Azetidines; Biological Transport; Cattle; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Inhibitory Concentration 50; Structure-Activity Relationship | 2010 |
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.
Topics: GABA Plasma Membrane Transport Proteins; Hydrazones; Mass Spectrometry | 2013 |
Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors.
Topics: Animals; Anticonvulsants; Biological Transport; Cell Membrane; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Mice; Neuroprotective Agents; Nipecotic Acids; Structure-Activity Relationship; Vinyl Compounds | 2013 |
Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.
Topics: Drug Evaluation, Preclinical; GABA Uptake Inhibitors; Nipecotic Acids | 2016 |
Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1.
Topics: Binding Sites; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; HEK293 Cells; Humans; Mass Spectrometry; Molecular Structure; N-Acetylglucosaminyltransferases; Oximes; Small Molecule Libraries; Structure-Activity Relationship | 2019 |
Comparison of the effect of the GABA uptake blockers, tiagabine and nipecotic acid, on inhibitory synaptic efficacy in hippocampal CA1 neurones.
Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Neurons; Nipecotic Acids; Proline; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Tiagabine | 1992 |
The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Epilepsy; Female; GABA Agents; Male; Motor Activity; Myoclonus; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Oximes; Papio; Photic Stimulation; Proline; Rats; Rats, Inbred Strains; Tiagabine | 1995 |
The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
Topics: Animals; Anticonvulsants; GABA Antagonists; gamma-Aminobutyric Acid; Molecular Structure; Nicotinic Acids; Nipecotic Acids; Proline; Prosencephalon; Rats; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Tiagabine | 1993 |
Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Entorhinal Cortex; Epilepsy; Female; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; Muscimol; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Proline; Rats; Rats, Wistar; Tiagabine | 1996 |
1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.
Topics: Animals; Carrier Proteins; Cell Line; Cricetinae; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Piperidines; Proline; Tiagabine | 1997 |
Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1.
Topics: Aminobutyrates; Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression; Humans; Kidney; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Ouabain; Rats; Receptors, GABA; Tiagabine; Tritium | 2002 |
Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.
Topics: Animals; Cricetinae; Disease Progression; Dose-Response Relationship, Drug; Dystonia; Female; GABA Antagonists; Injections, Intraperitoneal; Male; Mutation; Nipecotic Acids; Oximes; Random Allocation; Severity of Illness Index; Tiagabine; Time Factors; Treatment Outcome | 2005 |
Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors.
Topics: Animals; Anticonvulsants; Carboxylic Acids; Chemistry, Pharmaceutical; Drug Design; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Imidazoles; Inhibitory Concentration 50; Mice; Models, Chemical; Nipecotic Acids; Piperidines; Structure-Activity Relationship; Temperature; Tiagabine | 2007 |
Homology modelling of the GABA transporter and analysis of tiagabine binding.
Topics: Amino Acid Sequence; Anticonvulsants; Binding Sites; Drug Design; GABA Plasma Membrane Transport Proteins; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Nipecotic Acids; Sequence Alignment; Structural Homology, Protein; Tiagabine | 2010 |
A steered molecular dynamics study of binding and translocation processes in the GABA transporter.
Topics: Anticonvulsants; Binding Sites; Cytoplasm; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Nipecotic Acids; Protein Binding; Protein Conformation; Tiagabine | 2012 |
Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling.
Topics: Amino Acids; Animals; Biological Transport; Brain; Ergolines; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Models, Molecular; Radioligand Assay; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship | 2004 |
Design, synthesis, and biological evaluation of the N-diarylalkenyl-piperidinecarboxylic acid derivatives as GABA uptake inhibitors (I).
Topics: Animals; Biological Transport; Carboxylic Acids; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; GABA Agonists; gamma-Aminobutyric Acid; Humans; Inhibitory Concentration 50; Models, Chemical; Neurons; Nipecotic Acids; Pipecolic Acids; Structure-Activity Relationship; Tiagabine | 2006 |
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.
Topics: Animals; Cells, Cultured; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Inhibitory Concentration 50; Isoxazoles; Mice; Neurons | 2013 |
Development of New Photoswitchable Azobenzene Based γ-Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation.
Topics: Azo Compounds; Biological Transport; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Molecular Docking Simulation; N-Acetylglucosaminyltransferases; Nipecotic Acids; Photochemical Processes; Protein Conformation; Structure-Activity Relationship | 2018 |