tiagabine has been researched along with n-(4,4-diphenyl-3-butenyl)nipecotic acid in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Höfner, G; Kragler, A; Wanner, KT | 1 |
| Faust, MR; Höfner, G; Pabel, J; Wanner, KT | 1 |
| Lutz, TA; Petrera, M; Sindelar, M; Wanner, KT | 1 |
| Hellenbrand, T; Höfner, G; Wanner, KT; Wein, T | 1 |
| Kern, F; Wanner, KT | 1 |
| Borden, LA; Branchek, TA; Gluchowski, C; Murali Dhar, TG; Smith, KE; Weinshank, RL | 1 |
| Morimoto, K; Sato, H; Suwaki, H; Watanabe, T; Yamamoto, Y | 1 |
| Hiemke, C; Schmitt, U | 1 |
| Babot, Z; Cristòfol, R; Schousboe, A; Sonnewald, U; Suñol, C; Waagepetersen, HS | 1 |
9 other study(ies) available for tiagabine and n-(4,4-diphenyl-3-butenyl)nipecotic acid
| Article | Year |
|---|---|
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.
Topics: Animals; Benzylamines; Cell Line; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Methylation; Mice; Molecular Structure; Structure-Activity Relationship | 2008 |
Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.
Topics: Animals; Azetidines; Biological Transport; Cattle; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Inhibitory Concentration 50; Structure-Activity Relationship | 2010 |
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.
Topics: GABA Plasma Membrane Transport Proteins; Hydrazones; Mass Spectrometry | 2013 |
Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.
Topics: Drug Evaluation, Preclinical; GABA Uptake Inhibitors; Nipecotic Acids | 2016 |
Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1.
Topics: Binding Sites; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; HEK293 Cells; Humans; Mass Spectrometry; Molecular Structure; N-Acetylglucosaminyltransferases; Oximes; Small Molecule Libraries; Structure-Activity Relationship | 2019 |
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
Topics: Animals; Anticonvulsants; Carrier Proteins; Cell Line; Cloning, Molecular; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Humans; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nicotinic Acids; Nipecotic Acids; Organic Anion Transporters; Oximes; Pyridines; Rats; Recombinant Proteins; Structure-Activity Relationship; Tiagabine; Transfection | 1994 |
Antiepileptic effects of tiagabine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Picrotoxin; Rats; Rats, Sprague-Dawley; Tiagabine; Valproic Acid | 1997 |
Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze.
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Carrier Proteins; Dose-Response Relationship, Drug; Environment; Exploratory Behavior; GABA Agents; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Male; Membrane Proteins; Membrane Transport Proteins; Motor Activity; Nipecotic Acids; Organic Anion Transporters; Rats; Tiagabine | 1999 |
A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures.
Topics: Animals; Betaine; Cells, Cultured; Cerebellum; GABA Agents; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Lipotropic Agents; Mice; Neurons; Nipecotic Acids; Tiagabine; Vesicular Glutamate Transport Protein 1 | 2010 |