tiagabine has been researched along with gamma-aminobutyric acid in 213 studies
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
*gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.47) | 18.7374 |
| 1990's | 85 (39.91) | 18.2507 |
| 2000's | 86 (40.38) | 29.6817 |
| 2010's | 33 (15.49) | 24.3611 |
| 2020's | 8 (3.76) | 2.80 |
| Authors | Studies |
|---|---|
| Borden, LA; Branchek, TA; Dhar, TG; Gluchowski, C; Smith, KE; Tyagarajan, S; Weinshank, RL | 1 |
| Dörnyei, G; Gács-Baitz, E; Héja, L; Incze, M; Kardos, J; Kovács, I; Peredy-Kajtár, M; Szántay, C; Szárics, E; Temesváriné-Major, E | 1 |
| Lutz, TA; Petrera, M; Sindelar, M; Wanner, KT | 1 |
| Höfner, G; Quandt, G; Wanner, KT | 1 |
| Kern, F; Wanner, KT | 1 |
| Höfner, G; Huber, SK; Wanner, KT | 1 |
| Fijałkowski, Ł; Furgała, A; Gryzło, B; Höfner, GC; Kulig, K; Malawska, B; Malawska, K; Nowaczyk, A; Podkowa, A; Rapacz, A; Sałat, K; Wanner, KT; Zaręba, P; Żmudzki, P | 1 |
| Andersen, KE; Braestrup, C; Knutsen, LJ; Suzdak, PD; Swedberg, MD | 1 |
| Lambert, JD; Roepstorff, A | 2 |
| Fink-Jensen, A; Hansen, L; Judge, ME; Nielsen, PG; Suzdak, PD; Swedberg, MD | 1 |
| Andersen, KE; Frederiksen, K; Knutsen, LJ; Nielsen, EB; Suzdak, PD; Sørensen, PO | 1 |
| Diemer, NH; Johansen, FF | 1 |
| Browne, SE; Pertwee, RG; Ross, TM; Stretton, CD | 1 |
| Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD | 1 |
| Andersen, KE; Andersen, PH; Braestrup, C; Frederiksen, K; Jansen, JA; Knutsen, LJ; Mortensen, A; Nielsen, EB; Sonnewald, U; Suzdak, PD | 1 |
| Greentree, SG; Pertwee, RG; Swift, PA | 1 |
| Gustavson, LE; Mengel, HB | 1 |
| Jansen, JA; Suzdak, PD | 1 |
| Bowery, NG; Lemos, T; Richards, DA; Whitton, PS | 1 |
| Suzdak, PD; Thomsen, C | 1 |
| Blezer, EH; Coenen, AM; van Luijtelaar, EL | 1 |
| Gunawan, S; Treiman, DM; Walton, NY | 1 |
| Beran, RG | 1 |
| Friedman, MB; Gao, XM; Kakigi, T; Tamminga, CA | 1 |
| Brodie, MJ; Leach, JP | 2 |
| Patsalos, PN; Sander, JW | 1 |
| Gram, L | 3 |
| Harden, CL | 1 |
| Pierce, MW; Shu, VS | 1 |
| Ramsay, RE; Slater, JD | 1 |
| Mayfield, RD; Zahniser, NR | 1 |
| al-Tikriti, MS; Baldwin, RM; Bradberry, C; Bremner, JD; During, M; Malison, RT; Seibyl, JP; Sybirska, E; Zea-Ponce, Y; Zoghbi, S | 1 |
| Andersen, KE; Braestrup, C; Grønwald, FC; Jørgensen, AS; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD; Sørensen, PO | 1 |
| Bialer, M | 1 |
| Leppik, IE | 2 |
| Ben-Menachem, E | 1 |
| Schachter, SC | 2 |
| Brodie, MJ | 2 |
| Inglefield, JR; Perry, JM; Schwartz, RD | 1 |
| Draguhn, A; Heinemann, U; Meierkord, H; Pfeiffer, M | 1 |
| Halonen, T; Jansen, JA; Nissinen, J; Pitkänen, A | 1 |
| Brodie, MJ; Butler, E; Carswell, A; Leach, JP; Majid, A; Sills, GJ; Thompson, GG | 1 |
| Chadwick, DW; Kadir, ZA; Marson, AG | 1 |
| Meldrum, BS | 1 |
| Chadwick, DW; Kadir, Z; Marson, T | 1 |
| Aikiä, M; Kälviäinen, R; Mervaala, E; Pitkänen, A; Riekkinen, PJ; Saukkonen, AM | 1 |
| Andreasen, M; Fueta, Y; Lambert, JD; Roepstorff, A | 1 |
| Draguhn, A; Heinemann, U | 1 |
| Cascino, GD; Graves, NM; Gustavson, LE; Leppik, IE; Pixton, GC; So, EL; Wolff, D | 1 |
| Brodie, MJ; Wilson, EA | 1 |
| Shorvon, S; Stefan, H | 1 |
| Hosford, DA; Wang, Y | 1 |
| Egebjerg, J; Sørensen, PO; Thomsen, C | 1 |
| Bowery, NG; Richards, DA | 1 |
| Brodie, MJ; Butler, E; Forrest, G; Leach, JP; Sills, GJ; Thompson, GG | 1 |
| Dalby, NO; Nielsen, EB | 1 |
| Pellock, JM | 3 |
| Herranz, JL | 2 |
| Ben-Ari, Y; Caillard, O; Gaïarsa, JL; McLean, HA | 1 |
| Bazil, CW; Pedley, TA | 1 |
| Deisz, RA; Faulhaber, J; Lancel, M | 1 |
| Morimoto, K; Sato, H; Suwaki, H; Watanabe, T; Yamamoto, Y | 1 |
| Anderson, GD | 1 |
| Bourgeois, BF | 1 |
| Draguhn, A; Engel, D; Frahm, C; Gloveli, T; Heinemann, U; Schmitz, D | 1 |
| Wilner, AN | 1 |
| Ladurner, G; Löscher, W; Moroder, T; Nagler, M; Staffen, W; Trinka, E | 1 |
| Bartolini, A; Ipponi, A; Lamberti, C; Malmberg-Aiello, P; Medica, A | 1 |
| Ben-Menachem, E; Cramer, JA; Fisher, R; French, J; Mattson, RH | 1 |
| Bowery, NG; Davies, CC; Sutch, RJ | 1 |
| Chan, PK; Yung, WH | 1 |
| Eckstein-Ludwig, U; Fei, J; Schwarz, W | 1 |
| Capek, R; Esplin, B; Jackson, MF | 1 |
| Appleton, R; Pellock, JM | 1 |
| Privitera, MD | 1 |
| Sah, R; Schwartz-Bloom, RD | 1 |
| Kardos, J; Kovács, I; Nyitrai, G; Skuban, N | 1 |
| Cleton, A; Danhof, M; de Greef, HJ; Edelbroek, PM; Voskuyl, RA | 1 |
| Chapman, AG; Meldrum, BS | 1 |
| Perucca, E | 1 |
| Bogdanovic, N; Marcusson, J; Nägga, K | 1 |
| Crawford, PM; Datta, PK | 1 |
| Czuczwar, SJ | 1 |
| Hiemke, C; Schmitt, U | 1 |
| Vajda, FJ | 1 |
| Altorf, BA; Cleton, A; Danhof, M; Voskuyl, RA | 2 |
| Brodie, MJ; Butler, E; Duncan, R; Fraser, CM; Howatson, A; Lindsay, K; Sills, GJ; Thompson, GG | 1 |
| Dalby, NO | 1 |
| Bingmann, D; Bonnet, U; Hufnagel, A; Leniger, T; Wiemann, M | 1 |
| Foletti, GB | 1 |
| Johannessen, SI; Nakken, KO; Rytter, E | 1 |
| Belhage, B; Lund, TM; Schousboe, A; Timmermann, DB | 1 |
| Draguhn, A; Engel, D; Frahm, C | 1 |
| Aldenkamp, AP | 1 |
| Bauer, CA; Brozoski, TJ | 1 |
| Scholze, P; Singer, EA; Sitte, HH | 1 |
| Blennow, K; Dandenell, AK; Davidsson, P; Marcusson, J; Sundman-Eriksson, I | 1 |
| Benavente Aguilar, I; Gazulla Abío, J | 1 |
| Gentili, G; Grassi, E; Mauguière, F; Mazza, S; Restuccia, D; Tonali, P; Valeriani, M | 1 |
| Calabrese, JR; Kroeker, G; Kusumakar, V; Rao, R; Scarrow, G; Yatham, LN | 1 |
| Morris, HH | 1 |
| Brouns, R; Van Paesschen, W | 1 |
| Baziany, A; Gordon, S; Hasan Rajput, A; Hussain, M; Iqbal, S; Miyashita, H; Shuaib, A; Wright, S | 1 |
| Birnbaum, AK; Laughlin, TM; Tram, KV; Wilcox, GL | 1 |
| Boon, PA; van Rijckevorsel, K | 1 |
| Casas-Fernández, C; Domingo-Jiménez, R | 1 |
| Köhling, R; König, K; Lücke, A; Mayer, T; Speckmann, EJ; Wolf, P | 1 |
| Sirven, JI | 1 |
| Rekling, JC | 1 |
| Draguhn, A; Frahm, C; Stief, F; Zuschratter, W | 1 |
| Bergin, AM; Connolly, M | 1 |
| Lydiard, RB | 1 |
| Peng, W; Simantov, R | 1 |
| Shelton, RC | 1 |
| Czuczwar, SJ; Luszczki, JJ; Parada-Turska, J; Swiader, M | 1 |
| Johannessen, SI; Perucca, E | 1 |
| Benavente Aguilar, I; Feijóo de Freixo, M; Gazulla Abío, J; Val Adán, P | 1 |
| Bernardi, G; Calabresi, P; Costa, C; Leone, G; Pisani, F; Saulle, E | 1 |
| Helmers, SL; LaRoche, SM | 1 |
| Czuczwar, SJ; Luszczki, JJ | 2 |
| Gau, CS; Lin, CJ; Liou, HH; Shyu, MK; Wu, SP | 1 |
| Stahl, SM | 1 |
| Abou-Khalil, B; Bautista, J; Bazil, C; Bergen, D; Beydoun, A; Bourgeois, B; Browne, T; Faught, RE; Fischer, JH; French, JA; Gidal, B; Glauser, TA; Harden, CL; Hirtz, D; Kanner, AM; Marks, WJ; Montouris, GD; Nespeca, M; Sachdeo, RC; Schachter, SC; Stern, J; Theodore, WH; Turk, WR; Wilner, A | 3 |
| Yatham, LN | 1 |
| Benz, AM; Ishikawa, M; Izumi, M; Izumi, Y; Thio, LL; Zorumski, CF | 1 |
| Glaser, PE; Hays, LR; Lile, JA; Rush, CR; Stoops, WW | 1 |
| Korpi, ER; Möykkynen, T; Ogris, W; Sieghart, W; Sinkkonen, ST; Vekovischeva, OY; Wisden, W | 1 |
| Larsson, OM; Sarup, A; Schousboe, A; White, HS | 1 |
| Benavente Aguilar, I; Capablo Liesa, JL; Gazulla Abío, J | 1 |
| Barenbaum, RD; Rilla Manta, L | 1 |
| Bolvig, T; Clausen, RP; Falch, E; Frølund, B; Hansen, SL; Krogsgaard-Larsen, P; Larsson, OM; Perregaard, J; Petersen, G; Sarup, A; Schousboe, A; Slough, S; Watson, WP; White, HS | 1 |
| Fueta, Y; Kunugita, N; Schwarz, W | 1 |
| Hoffman, DA | 1 |
| Culligan, K; Kosten, T; Mouratidis, M; Sofuoglu, M; Yoo, S | 1 |
| Baghai, TC; Ella, R; Eser, D; Kathmann, N; Moller, HJ; Padberg, F; Rupprecht, R; Schule, C; Zwanzger, P | 1 |
| Guo, L; Jiang, H; Lin, G; Luo, X; Wen, R; Xu, L; Zhang, J; Zheng, J | 1 |
| Laute, MA; Manto, M; Pandolfo, M | 1 |
| Brown, C; Ondrasik, J; Pollack, MH; Rickels, K; Roy-Byrne, PP; Snyder, H; Van Ameringen, M | 1 |
| Carpenter, LL; Haggarty, R; Mello, AF; Mello, MF; Price, LH; Schecter, JM; Tyrka, AR | 1 |
| Kosten, TR; Sofuoglu, M | 1 |
| Hasan, A; Lang, N; Paulus, W; Sueske, E; Tergau, F | 1 |
| Filip, M; Frankowska, M; Gołda, A; Przegaliński, E; Vetulani, J; Zaniewska, M | 2 |
| Desai, R; Gonsai, K; González, G; Kosten, TR; Oliveto, A; Poling, J; Sofuoglu, M | 1 |
| Benavente, I; Gazulla, J; Sarasa Barrio, M | 1 |
| Nihalani, N; Schwartz, TL | 1 |
| Feuerstein, TJ; Stefan, H | 1 |
| Czarnecka, E; Pietrzak, B | 1 |
| Johannessen, SI; Tomson, T | 1 |
| Ammassari-Teule, M; Bernardi, G; Biamonte, F; Keller, F; Marinelli, S; Marrone, MC; Mercuri, NB; Sgobio, CA | 1 |
| Hassel, B; Henjum, S | 1 |
| Froestl, W; Griffiths, RR; Kaminski, BJ; Weerts, EM | 1 |
| Bartenstein, P; Buchholz, HG; Chechko, N; Dielentheis, TF; Fehr, C; Gründer, G; Hohmann, N; Landvogt, C; Schreckenberger, M; Urban, R; Yakushev, I | 1 |
| Tolmacheva, EA; van Luijtelaar, G | 1 |
| Benavente, I; Gazulla, J; Sarasa, M | 1 |
| Fang, K; Lin, G; Liu, X; Zhang, J; Zhang, P | 1 |
| Cai, Y; Chen, C; Fei, J; Gong, N; Wang, Z; Wu, Y; Xu, T; Xu, Y; Zhang-Nunes, S | 1 |
| Hutson, PH; McDonald, LM; Sheppard, WF; Sohal, B; Staveley, SM; Tattersall, FD | 1 |
| Døring, S; Schousboe, A; Waagepetersen, HS | 1 |
| Cho, RY; Frankle, WG; Lewis, DA; Litschge, M; Mason, NS; Mathis, CA; Narendran, R; Price, JC; Vora, S | 1 |
| Auvinen, A; Fallah, M; Keränen, T; Peltola, J; Peltola, M; Raitanen, J | 1 |
| Dang, CV; Nelson, L; Wade, JF; Wasserberger, J | 1 |
| Czuczwar, M; Czuczwar, SJ; Kolacz, A; Luszczki, JJ; Przesmycki, K | 1 |
| Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M | 1 |
| Marsh, AD; Marsh, DR; Meisner, JG | 1 |
| Ali, F; Cavanna, AE; McCorry, D; Rickards, HE | 1 |
| Kilb, W; Luhmann, HJ; Richter, D | 1 |
| Babot, Z; Cristòfol, R; Schousboe, A; Sonnewald, U; Suñol, C; Waagepetersen, HS | 1 |
| Froestl, W | 1 |
| Ascenção, R; Borges, M; Costa, J; Fareleira, F; Sampaio, C; Vaz-Carneiro, A | 1 |
| Chen, CM; Cho, RY; Frankle, WG; Himes, M; Lewis, DA; Mason, NS; Mathis, CA; Narendran, R; Walker, C | 1 |
| David, L; Jørgensen, FS; Skovstrup, S; Taboureau, O | 1 |
| Hamandi, K; Lingford-Hughes, A; Muthukumaraswamy, SD; Myers, JF; Nutt, DJ; Singh, KD; Wilson, SJ | 2 |
| Catterall, WA; Cheah, CS; Cho, AR; Oakley, JC; Scheuer, T | 1 |
| Althof, D; Bettler, B; Booker, SA; Frotscher, M; Gross, A; Hearing, M; Kulik, Á; Shigemoto, R; Vida, I; Watanabe, M; Wickman, K | 1 |
| Lee, CY; Liou, HH | 1 |
| El-Khoury, R; Ghata, A; Matagne, V; Panayotis, N; Roux, JC; Villard, L | 1 |
| Edden, RA; Evans, CJ; Kalk, NJ; Lingford-Hughes, AR; Myers, JF | 1 |
| Cunningham, VJ; Erritzoe, D; Hammers, A; Kalk, NJ; Lingford-Hughes, AR; Myers, JF; Nutt, DJ; Riano Barros, D; Stokes, PR; Turkheimer, FE; Watson, BJ; Wilson, SJ | 1 |
| Barbanel, G; Boubal, M; Cambonie, G; Cavalier, M; Cohen-Solal, C; Crouzin, N; de Jesus Ferreira, MC; Guiramand, J; Rideau Batista Novais, A; Vignes, M | 1 |
| Lingford-Hughes, A; Muthukumaraswamy, S; Myers, J; Nutt, D; Papadopoulos, A; Wilson, S | 1 |
| De Santis, V; Lingford-Hughes, A; Myers, J; Nutt, D; Parker, C; Quelch, D; Strege, A; Tyacke, R; Wells, L | 1 |
| Deeb, S; Logan, BK; McKeown, DA; Scott, KS; Torrance, HJ; Wylie, FM | 1 |
| Behar, KL; de Graaf, RA; Patel, AB; Rothman, DL | 1 |
| Ecker, GF; Holy, M; Jurik, A; Sitte, HH; Stockner, T; Zdrazil, B | 1 |
| Cull-Candy, SG; Dupree, JL; Edwards, J; Farrant, M; Gallo, V; Harvey, L; Hübner, CA; Li, P; McEllin, B; Scafidi, J; Sun, D; Zonouzi, M | 1 |
| Eftekhari, S; Hassanzadeh, G; Joghataei, MT; Shahrokhi, A; Vousooghi, N; Zarrindast, MR | 1 |
| Cho, RY; Frankle, WG; Himes, ML; Lewis, DA; Mason, NS; Narendran, R; Paris, J; Prasad, KM; Walker, C | 1 |
| Cock, HR | 1 |
| Campbell, AE; Hamandi, K; Lingford-Hughes, A; Magazzini, L; Muthukumaraswamy, SD; Myers, JF; Nutt, DJ; Singh, KD; Sumner, P; Wilson, SJ | 1 |
| Arellano, RO; Bassi, S; Conti, F; Fattorini, G; Matute, C; Melone, M; Sánchez-Gómez, MV | 1 |
| Jabeen, I; Zafar, S | 1 |
| Adams, NE; Bevan-Jones, WR; Cope, TE; Friston, K; Holland, N; Hughes, LE; Murley, AG; Nesbitt, D; Passamonti, L; Phillips, HN; Rouse, MA; Rowe, JB; Shaw, AD; Street, D | 1 |
| Chandler, HL; Hamandi, K; Hammers, A; Muthukumaraswamy, SD; Shaw, AD; Singh, KD | 1 |
| Akhtar, MJ; Bhatia, R; Kumar, B; Kumar, P; Mehta, V; Singh, K | 1 |
| Aduri, NG; Cherezov, V; Gati, C; Han, GW; Katritch, V; Lam, JH; Motiwala, Z; Shaye, H | 1 |
| Dayan-Alon, O; Kanner, BI | 1 |
| Huang, J; Kong, F; Lei, J; Tan, J; Yan, C; Yuan, Y; Zhu, A | 1 |
56 review(s) available for tiagabine and gamma-aminobutyric acid
| Article | Year |
|---|---|
A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Ischemia; Dogs; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; Kindling, Neurologic; Mice; Mice, Inbred DBA; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Receptors, GABA; Seizures; Self Administration; Tiagabine | 1995 |
Newer antiepileptic drugs. Towards an improved risk-benefit ratio.
Topics: Acetamides; Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Piracetam; Propylene Glycols; Risk Factors; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 1994 |
New antiepileptic drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Triazines; Vigabatrin | 1994 |
Handling seizure data: special problems.
Topics: Anticonvulsants; Clinical Trials as Topic; Data Interpretation, Statistical; Drug Therapy, Combination; Electroencephalography; Epilepsy; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Tiagabine; Valproic Acid | 1993 |
Antiepileptic drugs in clinical development.
Topics: Acetates; Amines; Aminocaproates; Anticonvulsants; Brain; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Structure-Activity Relationship; Synaptic Transmission; Tiagabine; Topiramate; Triazines; Vigabatrin | 1993 |
Comparative pharmacokinetics of the newer antiepileptic drugs.
Topics: Acetamides; Acetates; Amines; Aminocaproates; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dioxolanes; Felbamate; Flunarizine; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1993 |
Tiagabine pharmacology in profile.
Topics: Aged; Animals; Anticonvulsants; Biological Availability; Delayed-Action Preparations; Drug Interactions; Epilepsy; gamma-Aminobutyric Acid; Half-Life; Hippocampus; Humans; Kindling, Neurologic; Mice; Nipecotic Acids; Rats; Receptors, GABA; Synaptic Transmission; Tiagabine | 1995 |
New antiepileptic drugs: a systematic review of their efficacy and tolerability.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Child; Cross-Over Studies; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Male; Middle Aged; Nipecotic Acids; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 1996 |
Update on the mechanism of action of antiepileptic drugs.
Topics: 4-Aminobutyrate Transaminase; Acetamides; Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Ion Channels; Lamotrigine; Membrane Potentials; Mice; Neurotransmitter Agents; Nipecotic Acids; Phenethylamines; Phenylcarbamates; Propylene Glycols; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tiagabine; Topiramate; Triazines; Vigabatrin | 1996 |
Pharmacokinetics of new antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Carbamazepine; Cyclohexanecarboxylic Acids; Enzyme Induction; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Humans; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1996 |
Clinical administration of new antiepileptic drugs: an overview of safety and efficacy.
Topics: Acetates; Amines; Anticonvulsants; Confidence Intervals; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Therapy, Combination; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Odds Ratio; Placebos; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 1996 |
New antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1996 |
Overview of the safety of newer antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1997 |
Overview of lamotrigine and the new antiepileptic drugs: the challenge.
Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Exanthema; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Treatment Outcome; Triazines; Valproic Acid; Vigabatrin | 1997 |
Tiagabine.
Topics: Anticonvulsants; Epilepsies, Partial; gamma-Aminobutyric Acid; Humans; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Tiagabine | 1998 |
Advances in the medical treatment of epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approval; Drug Design; Drug Interactions; Drug Resistance; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Injections, Intravenous; Ketones; Lamotrigine; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Phenylcarbamates; Phenytoin; Prodrugs; Propylene Glycols; Tiagabine; Topiramate; Triazines; United States; Valproic Acid; Vigabatrin | 1998 |
A mechanistic approach to antiepileptic drug interactions.
Topics: Acetates; Amines; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Cyclohexanecarboxylic Acids; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Glucuronosyltransferase; Humans; Lamotrigine; Mixed Function Oxygenases; Nipecotic Acids; Phenobarbital; Phenylcarbamates; Phenytoin; Propylene Glycols; Tiagabine; Topiramate; Triazines; Valproic Acid; Vigabatrin | 1998 |
[Tiagabine: recent findings and recommendations for dosage].
Topics: Dose-Response Relationship, Drug; Epilepsy, Complex Partial; gamma-Aminobutyric Acid; Humans; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Synapses; Tiagabine | 1998 |
Role of new and established antiepileptic drugs.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Epilepsies, Partial; Epilepsy; Felbamate; Fructose; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Teratogens; Tiagabine; Topiramate; Triazines; Vigabatrin | 1998 |
New antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Approval; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; United States; Vigabatrin | 1998 |
New medication options for patients with epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines | 1998 |
Clinical and EEG findings in complex partial status epilepticus with tiagabine.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Epilepsy, Complex Partial; Female; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Tiagabine; Vigabatrin | 1999 |
New antiepileptic drugs: comparison of key clinical trials.
Topics: Acetates; Amines; Anticonvulsants; Controlled Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind Method; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Placebos; Research Design; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin | 1999 |
Use of new antiepileptic drugs in the treatment of childhood epilepsy.
Topics: Acetates; Adult; Age Factors; Amines; Anticonvulsants; Child; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Spasms, Infantile; Tiagabine; Topiramate; Triazines; Vigabatrin | 1999 |
Tiagabine.
Topics: Anticonvulsants; Brain; Brain Chemistry; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Tiagabine; Treatment Outcome | 1999 |
Evidence-based medicine and antiepileptic drugs.
Topics: Acetates; Adult; Amines; Anticonvulsants; Confidence Intervals; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Electric Stimulation Therapy; Epilepsies, Partial; Evidence-Based Medicine; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Odds Ratio; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Triazines; Vagus Nerve | 1999 |
Managing pediatric epilepsy syndromes with new antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin | 1999 |
Basic mechanisms of gabitril (tiagabine) and future potential developments.
Topics: Animals; Anticonvulsants; Bipolar Disorder; Carrier Proteins; Epilepsy; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Kindling, Neurologic; Limbic System; Membrane Proteins; Membrane Transport Proteins; Mice; Nipecotic Acids; Organic Anion Transporters; Pain; Rats; Tiagabine | 1999 |
The clinical pharmacokinetics of the new antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Biological Availability; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Zonisamide | 1999 |
[GABA-ergic system and antiepileptic drugs].
Topics: Acetates; Amines; Anticonvulsants; Binding, Competitive; Calcium Channels; Chloride Channels; Cyclohexanecarboxylic Acids; Epilepsy; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Humans; Nipecotic Acids; Receptors, GABA; Sodium Channels; Tiagabine; Vigabatrin | 2000 |
New antiepileptic drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2000 |
[Adverse effects of antiepileptic agents].
Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Clobazam; Cyclohexanecarboxylic Acids; Drug Utilization; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Norway; Piracetam; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2000 |
Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Acids; Double-Blind Method; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Placebos; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2002 |
Pharmacokinetics of new anticonvulsants in psychiatry.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Mental Disorders; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Psychiatry; Tiagabine; Topiramate; Triazines | 1998 |
[Characteristics and indications of tiagabine].
Topics: Animals; Anticonvulsants; Drug Interactions; Epilepsy; gamma-Aminobutyric Acid; Humans; Molecular Structure; Neurons; Nipecotic Acids; Tiagabine | 2002 |
Antiepileptic drug therapy for adults: when to initiate and how to choose.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Recurrence; Risk Factors; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2002 |
New antiepileptic drug therapies.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Dioxolanes; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Phenytoin; Piracetam; Propylene Glycols; Thiazines; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2002 |
The role of GABA in anxiety disorders.
Topics: Acetates; Amines; Anxiety Disorders; Benzodiazepines; Cyclohexanecarboxylic Acids; GABA Agents; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Nipecotic Acids; Receptors, GABA-A; Synaptic Transmission; Tiagabine | 2003 |
Treating bipolar depression.
Topics: Acetates; Affect; Amines; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Lithium Compounds; Nipecotic Acids; Olanzapine; Oxcarbazepine; Pirenzepine; Tiagabine; Topiramate; Treatment Outcome; Triazines; Valproic Acid; Zonisamide | 2003 |
The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2003 |
The new antiepileptic drugs: scientific review.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Tiagabine; Topiramate; Triazines; Zonisamide | 2004 |
Anticonvulsants as anxiolytics, part 1: tiagabine and other anticonvulsants with actions on GABA.
Topics: Anti-Anxiety Agents; Anticonvulsants; Anxiety Disorders; Carbamazepine; Fructose; GABA Agonists; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Synapses; Tiagabine; Topiramate; Triazines; Valproic Acid | 2004 |
Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Antipsychotic Agents; Carbamazepine; Child; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Approval; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; United States; United States Food and Drug Administration; Zonisamide | 2004 |
Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Approval; Epilepsies, Partial; Epilepsy, Generalized; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Practice Patterns, Physicians'; Tiagabine; Topiramate; Triazines; United States; United States Food and Drug Administration; Zonisamide | 2004 |
Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epile
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Drug Resistance; Epilepsies, Partial; Epilepsy, Generalized; Evidence-Based Medicine; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2004 |
Newer anticonvulsants in the treatment of bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Depressive Disorder; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenytoin; Piracetam; Pregabalin; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2004 |
Emerging pharmacological strategies in the fight against cocaine addiction.
Topics: Adrenergic beta-Antagonists; Animals; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Disulfiram; Dopamine; Dopamine Agents; Dopamine beta-Hydroxylase; Drug Evaluation, Preclinical; Enzyme Inhibitors; GABA Agonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Modafinil; Nipecotic Acids; Propranolol; Randomized Controlled Trials as Topic; Tiagabine; Vaccines | 2006 |
Tiagabine in anxiety disorders.
Topics: Anxiety Disorders; Female; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Nipecotic Acids; Randomized Controlled Trials as Topic; Stress Disorders, Post-Traumatic; Tiagabine | 2006 |
Novel anticonvulsant drugs.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Piracetam; Pregabalin; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2007 |
Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed?
Topics: Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Monitoring; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Pregabalin; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2006 |
Emergent complications of the newer anticonvulsants.
Topics: Acidosis; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Overdose; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Psychoses, Substance-Induced; Seizures; Tiagabine; Topiramate; Triazines | 2010 |
New pharmacotherapies for pediatric seizures.
Topics: Adolescent; Amines; Animals; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Pediatrics; Piracetam; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin; Zonisamide | 2004 |
Behavioral and cognitive effects of anti-epileptic drugs.
Topics: Amines; Anticonvulsants; Antidepressive Agents; Behavior; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Lamotrigine; Neurotransmitter Agents; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Triazines; Vigabatrin | 2010 |
Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: a systematic review and meta-analysis.
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Levetiracetam; Nipecotic Acids; Piracetam; Randomized Controlled Trials as Topic; Tiagabine; Topiramate; Treatment Outcome | 2011 |
Drug-induced status epilepticus.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Phenobarbital; Phenytoin; Status Epilepticus; Tiagabine | 2015 |
Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies.
Topics: Anticonvulsants; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Tiagabine | 2022 |
20 trial(s) available for tiagabine and gamma-aminobutyric acid
| Article | Year |
|---|---|
Pharmacokinetics of tiagabine, a gamma-aminobutyric acid-uptake inhibitor, in healthy subjects after single and multiple doses.
Topics: Administration, Oral; Adult; Anticonvulsants; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Half-Life; Humans; Male; Microsomes, Liver; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Placebos; Tiagabine | 1995 |
Tiagabine: the safety landscape.
Topics: Adolescent; Aged; Anticonvulsants; Child; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Epilepsy; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Placebos; Proportional Hazards Models; Tiagabine; Treatment Outcome | 1995 |
International experience with tiagabine add-on therapy.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Australia; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Europe; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Middle Aged; Nipecotic Acids; Placebos; Tiagabine; Treatment Outcome; United States | 1995 |
Tiagabine monotherapy in the treatment of partial epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drugs, Investigational; Epilepsies, Partial; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Placebos; Tiagabine; Treatment Outcome | 1995 |
Long-term cognitive and EEG effects of tiagabine in drug-resistant partial epilepsy.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anticonvulsants; Cognition; Double-Blind Method; Electroencephalography; Epilepsies, Partial; Female; gamma-Aminobutyric Acid; Humans; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Tiagabine | 1996 |
Pharmacokinetics of tiagabine as add-on therapy in patients taking enzyme-inducing antiepilepsy drugs.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Circadian Rhythm; Enzyme Induction; Epilepsy; Female; gamma-Aminobutyric Acid; Half-Life; Humans; Male; Middle Aged; Nipecotic Acids; Tiagabine | 1995 |
[Tiagabine: a GABA-ergic anti-epileptic drug].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Double-Blind Method; Drug Tolerance; Epilepsy; gamma-Aminobutyric Acid; Humans; Middle Aged; Nipecotic Acids; Receptors, GABA; Synapses; Tiagabine | 1997 |
Contribution of GABAergic cortical circuitry in shaping somatosensory evoked scalp responses: specific changes after single-dose administration of tiagabine.
Topics: Adult; Evoked Potentials, Somatosensory; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Muscle, Skeletal; Neurons, Afferent; Nipecotic Acids; Proprioception; Somatosensory Cortex; Tiagabine | 2002 |
Third generation anticonvulsants in bipolar disorder: a review of efficacy and summary of clinical recommendations.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Acids; Double-Blind Method; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Nipecotic Acids; Placebos; Tiagabine; Topiramate; Treatment Outcome; Triazines; Zonisamide | 2002 |
Effects of tiagabine in combination with intravenous nicotine in overnight abstinent smokers.
Topics: Adult; Anticonvulsants; Arousal; Attention; Blood Pressure; Brain; Cross-Over Studies; Double-Blind Method; Female; gamma-Aminobutyric Acid; Heart Rate; Humans; Male; Neuropsychological Tests; Nicotine; Nipecotic Acids; Reward; Smoking Cessation; Substance Withdrawal Syndrome; Tiagabine | 2005 |
Saccadic eye velocity after selective GABAergic treatment with tiagabine in healthy volunteers.
Topics: Adult; Female; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Nipecotic Acids; Receptors, GABA-A; Saccades; Tiagabine | 2005 |
The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study.
Topics: Adult; Aged; Anxiety Disorders; Data Interpretation, Statistical; Double-Blind Method; Drug Administration Schedule; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Outcome Assessment, Health Care; Placebos; Psychiatric Status Rating Scales; Tiagabine; Treatment Outcome | 2005 |
Open-label tiagabine monotherapy for major depressive disorder with anxiety.
Topics: Adult; Ambulatory Care; Anxiety Disorders; Comorbidity; Depressive Disorder, Major; Drug Administration Schedule; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Pilot Projects; Psychiatric Status Rating Scales; Tiagabine; Treatment Outcome | 2006 |
Pregabalin exerts oppositional effects on different inhibitory circuits in human motor cortex: a double-blind, placebo-controlled transcranial magnetic stimulation study.
Topics: Adult; Amines; Anticonvulsants; Calcium Channels; Cyclohexanecarboxylic Acids; Double-Blind Method; Evoked Potentials, Motor; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Motor Cortex; Neural Inhibition; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Placebos; Pregabalin; Receptors, GABA-B; Recruitment, Neurophysiological; Tiagabine; Transcranial Magnetic Stimulation | 2006 |
Clinical efficacy of gabapentin versus tiagabine for reducing cocaine use among cocaine dependent methadone-treated patients.
Topics: Adult; Amines; Anti-Anxiety Agents; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Administration Schedule; Female; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Methadone; Narcotics; Nipecotic Acids; Tiagabine; Treatment Outcome | 2007 |
Tiagabine does not attenuate alcohol-induced activation of the human reward system.
Topics: Adult; Behavior, Addictive; Central Nervous System Depressants; Drug Synergism; Ethanol; Fluorodeoxyglucose F18; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Limbic System; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Positron-Emission Tomography; Radiopharmaceuticals; Reference Values; Reward; Single-Blind Method; Tiagabine | 2007 |
The effects of elevated endogenous GABA levels on movement-related network oscillations.
Topics: Adult; Beta Rhythm; Cortical Synchronization; Cross-Over Studies; Female; GABA Agonists; gamma-Aminobutyric Acid; Humans; Magnetoencephalography; Male; Motor Cortex; Movement; Nipecotic Acids; Signal Processing, Computer-Assisted; Tiagabine; Young Adult | 2013 |
Acute increases in synaptic GABA detectable in the living human brain: a [¹¹C]Ro15-4513 PET study.
Topics: Adult; Azides; Benzodiazepines; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Double-Blind Method; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Memory; Middle Aged; Nipecotic Acids; Positron-Emission Tomography; Psychomotor Performance; Radiopharmaceuticals; Receptors, GABA-A; Synapses; Tiagabine | 2014 |
Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: a study in healthy volunteers.
Topics: Adult; Brain; Brain Waves; Cross-Over Studies; Female; GABA Agonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Magnetoencephalography; Male; Nipecotic Acids; Pyridines; Rest; Single-Blind Method; Synapses; Tiagabine; Young Adult; Zolpidem | 2015 |
GABAergic cortical network physiology in frontotemporal lobar degeneration.
Topics: Aged; Cerebral Cortex; Cross-Over Studies; Double-Blind Method; Female; Frontotemporal Dementia; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetoencephalography; Male; Models, Neurological; Nerve Net; Supranuclear Palsy, Progressive; Synaptic Transmission; Tiagabine | 2021 |
138 other study(ies) available for tiagabine and gamma-aminobutyric acid
| Article | Year |
|---|---|
Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3.
Topics: Animals; Binding Sites; Biological Transport; Blood-Brain Barrier; Carrier Proteins; Cell Line; Cloning, Molecular; Drug Design; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Ligands; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Proline; Rats | 1994 |
Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling.
Topics: Amino Acids; Animals; Biological Transport; Brain; Ergolines; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Models, Molecular; Radioligand Assay; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship | 2004 |
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.
Topics: GABA Plasma Membrane Transport Proteins; Hydrazones; Mass Spectrometry | 2013 |
Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors.
Topics: Animals; Anticonvulsants; Biological Transport; Cell Membrane; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Mice; Neuroprotective Agents; Nipecotic Acids; Structure-Activity Relationship; Vinyl Compounds | 2013 |
Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1.
Topics: Binding Sites; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; HEK293 Cells; Humans; Mass Spectrometry; Molecular Structure; N-Acetylglucosaminyltransferases; Oximes; Small Molecule Libraries; Structure-Activity Relationship | 2019 |
Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of γ-aminobutyric acid transporter 1 (GAT1).
Topics: GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Oximes; Pyrrolidines; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2019 |
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; Hyperalgesia; Male; Mice; Molecular Docking Simulation; Molecular Structure; Neuralgia; Oxaliplatin; Pain Threshold; Protein Binding; Streptozocin; Structure-Activity Relationship | 2020 |
In vivo labeling of the central GABA uptake carrier with 3H-Tiagabine.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Carrier Proteins; Cell Membrane; Convulsants; Female; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Membrane Proteins; Membrane Transport Proteins; Mice; Motor Activity; Nipecotic Acids; Organic Anion Transporters; Rats; Receptors, GABA-A; Synaptosomes; Tiagabine | 1992 |
Comparison of the effect of the GABA uptake blockers, tiagabine and nipecotic acid, on inhibitory synaptic efficacy in hippocampal CA1 neurones.
Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Neurons; Nipecotic Acids; Proline; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Tiagabine | 1992 |
The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.
Topics: Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Globus Pallidus; Male; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Substantia Nigra; Tiagabine | 1992 |
NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.
Topics: Animals; Anticonvulsants; Astrocytes; Behavior, Animal; Brain; Carbolines; Cells, Cultured; Convulsants; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Neurons; Nicotinic Acids; Nipecotic Acids; Oximes; Pentylenetetrazole; Rats; Seizures; Synaptosomes; Tiagabine | 1992 |
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Male; Motor Activity; Nerve Degeneration; Neurons; Nipecotic Acids; Rats; Rats, Inbred Strains; Synaptic Transmission; Tiagabine | 1991 |
An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol.
Topics: Amino Acids; Amino Acids, Neutral; Analgesics; Animals; Anticonvulsants; Body Temperature; Cannabidiol; Dronabinol; Electric Stimulation; Flurazepam; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Nipecotic Acids; Pentylenetetrazole; Seizures; Tiagabine | 1991 |
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred DBA; Neurotransmitter Uptake Inhibitors; Nicotinic Acids; Nipecotic Acids; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Tiagabine | 1991 |
(R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hydrogen-Ion Concentration; Male; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Nipecotic Acids; Organic Anion Transporters; Rats; Rats, Inbred Strains; Sodium Chloride; Synaptosomes; Temperature; Tiagabine; Tissue Distribution | 1990 |
Drugs which stimulate or facilitate central GABAergic transmission interact synergistically with delta-9-tetrahydrocannabinol to produce marked catalepsy in mice.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Catalepsy; Dronabinol; Drug Synergism; Flumazenil; Flupenthixol; Flurazepam; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nipecotic Acids; Receptors, GABA-A; Strychnine; Taurine; Tiagabine | 1988 |
Extracellular GABA in the ventrolateral thalamus of rats exhibiting spontaneous absence epilepsy: a microdialysis study.
Topics: Animals; Baclofen; Electroencephalography; Epilepsy, Absence; Extracellular Space; GABA Antagonists; gamma-Aminobutyric Acid; Microdialysis; Nipecotic Acids; Organophosphorus Compounds; Potassium; Rats; Rats, Wistar; Stereoisomerism; Thalamus; Tiagabine | 1995 |
Effects of chronic tiagabine treatment on [3H]GABAA, [3H]GABAB and [3H]tiagabine binding to sections from mice brain.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Female; gamma-Aminobutyric Acid; Mice; Mice, Inbred Strains; Microtomy; Motor Activity; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Radioligand Assay; Receptors, GABA-A; Receptors, GABA-B; Tiagabine; Time Factors; Tritium | 1995 |
Effects of the GABA-uptake inhibitor tiagabine on electroencephalogram, spike-wave discharges and behaviour of rats.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy, Generalized; gamma-Aminobutyric Acid; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Inbred Strains; Tiagabine | 1995 |
Treatment of experimental status epilepticus with the GABA uptake inhibitor, tiagabine.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; gamma-Aminobutyric Acid; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Status Epilepticus; Tiagabine | 1994 |
New antiepileptic medications.
Topics: 4-Aminobutyrate Transaminase; Acetamides; Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Tiagabine; Triazines; Vigabatrin | 1995 |
Tiagabine inhibits haloperidol-induced oral dyskinesias in rats.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Haloperidol; Male; Mastication; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Single-Blind Method; Tiagabine | 1994 |
Factors contributing to the decay of the stimulus-evoked IPSC in rat hippocampal CA1 neurons.
Topics: Animals; Calcium; Electric Stimulation; Evoked Potentials; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Microelectrodes; Midazolam; Nipecotic Acids; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-B; Synapses; Tiagabine | 1994 |
Synergism with GABAergic drugs in refractory epilepsy.
Topics: 4-Aminobutyrate Transaminase; Adult; Drug Synergism; Epilepsy; Female; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Nipecotic Acids; Tiagabine; Vigabatrin | 1994 |
Tiagabine: a novel drug with a GABAergic mechanism of action.
Topics: Animals; Anticonvulsants; Drug Design; Drugs, Investigational; Epilepsy; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Prodrugs; Randomized Controlled Trials as Topic; Research Design; Synaptic Transmission; Tiagabine | 1994 |
Endogenous GABA release from rat striatal slices: effects of the GABAB receptor antagonist 2-hydroxy-saclofen.
Topics: Animals; Baclofen; Calcium; Chromatography, High Pressure Liquid; Corpus Striatum; Dose-Response Relationship, Drug; Electric Stimulation; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Nipecotic Acids; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Tiagabine | 1993 |
[123I]iomazenil SPECT imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brain.
Topics: Adult; Animals; Binding, Competitive; Brain; Dialysis; Female; Flumazenil; gamma-Aminobutyric Acid; Half-Life; Humans; Hypnotics and Sedatives; Iodine Radioisotopes; Lorazepam; Male; Nipecotic Acids; Ovariectomy; Papio; Receptors, GABA-A; Tiagabine; Tomography, Emission-Computed, Single-Photon | 1993 |
The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
Topics: Animals; Anticonvulsants; GABA Antagonists; gamma-Aminobutyric Acid; Molecular Structure; Nicotinic Acids; Nipecotic Acids; Proline; Prosencephalon; Rats; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Tiagabine | 1993 |
Epilepsy care: image of the future.
Topics: Anticonvulsants; Drug Therapy, Combination; Drugs, Investigational; Epilepsy; Forecasting; GABA Agents; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; Tiagabine | 1995 |
Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus.
Topics: Animals; Cell Death; gamma-Aminobutyric Acid; Gerbillinae; Hippocampus; Hypothermia; Male; Microdialysis; Neurons; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Reperfusion Injury; Tiagabine; Time Factors | 1995 |
Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Entorhinal Cortex; Epilepsy; Female; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; Muscimol; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Proline; Rats; Rats, Wistar; Tiagabine | 1996 |
Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticus.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Electroencephalography; gamma-Aminobutyric Acid; Hippocampus; Male; Maze Learning; Neurotransmitter Agents; Nipecotic Acids; Rats; Somatostatin; Status Epilepticus; Temporal Lobe; Tiagabine | 1996 |
Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes.
Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Tiagabine; Vigabatrin | 1996 |
Analysis of the kinetics of synaptic inhibition points to a reduction in GABA release in area CA1 of the genetically epileptic mouse, El.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Baclofen; Disease Models, Animal; Electric Stimulation; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Mice; Mice, Mutant Strains; Neural Inhibition; Nipecotic Acids; Receptors, GABA; Species Specificity; Synaptic Transmission; Tiagabine | 1996 |
Different mechanisms regulate IPSC kinetics in early postnatal and juvenile hippocampal granule cells.
Topics: Aging; Animals; Animals, Newborn; Electric Stimulation; Evoked Potentials; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission; Tiagabine | 1996 |
Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin, and topiramate against human absence seizures.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Absence; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Mice; Nipecotic Acids; Tiagabine; Topiramate; Triazines; Vigabatrin | 1997 |
1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.
Topics: Animals; Carrier Proteins; Cell Line; Cricetinae; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Piperidines; Proline; Tiagabine | 1997 |
Comparative effects of the GABA uptake inhibitors, tiagabine and NNC-711, on extracellular GABA levels in the rat ventrolateral thalamus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Basal Metabolism; Drug Evaluation, Preclinical; Epilepsy; gamma-Aminobutyric Acid; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Rats; Rats, Wistar; Thalamus; Tiagabine | 1996 |
Neurochemical actions of vigabatrin and tiagabine alone and in combination in mouse cortex.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Mice; Mice, Inbred ICR; Nipecotic Acids; Tiagabine; Vigabatrin | 1997 |
Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Gabapentin; gamma-Aminobutyric Acid; Lamotrigine; Male; Mice; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Tiagabine; Triazines; Vigabatrin | 1997 |
Ontogenesis of presynaptic GABAB receptor-mediated inhibition in the CA3 region of the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Baclofen; Calcium; Electric Stimulation; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organophosphorus Compounds; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-B; Synaptic Transmission; Tiagabine | 1998 |
Effect of the GABA uptake inhibitor tiagabine on sleep and EEG power spectra in the rat.
Topics: Animals; Electroencephalography; gamma-Aminobutyric Acid; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Wistar; Sleep; Tiagabine | 1998 |
Antiepileptic effects of tiagabine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Picrotoxin; Rats; Rats, Sprague-Dawley; Tiagabine; Valproic Acid | 1997 |
Laminar difference in GABA uptake and GAT-1 expression in rat CA1.
Topics: Animals; Axons; Carrier Proteins; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; In Situ Hybridization; Interneurons; Kinetics; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Pyramidal Cells; Rats; Rats, Wistar; Tiagabine | 1998 |
Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis.
Topics: Abdomen; Animals; Baclofen; Constriction, Pathologic; Dose-Response Relationship, Drug; Escape Reaction; Extracellular Space; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Microdialysis; Naloxone; Narcotic Antagonists; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Nociceptors; Organophosphorus Compounds; Pain; Pain Measurement; Pain Threshold; Psychomotor Performance; Receptors, GABA-B; Thalamus; Tiagabine | 1999 |
GABA release and uptake measured in crude synaptosomes from Genetic Absence Epilepsy Rats from Strasbourg (GAERS).
Topics: Aminooxyacetic Acid; Animals; Autoradiography; beta-Alanine; Cerebral Cortex; Epilepsy; GABA Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Nipecotic Acids; Oximes; Rats; Rats, Mutant Strains; Synaptosomes; Thalamus; Tiagabine; Tritium | 1999 |
Inhibitory postsynaptic currents of rat substantia nigra pars reticulata neurons: role of GABA receptors and GABA uptake.
Topics: Animals; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Nipecotic Acids; Patch-Clamp Techniques; Phosphinic Acids; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Substantia Nigra; Tiagabine | 1999 |
Inhibition of uptake, steady-state currents, and transient charge movements generated by the neuronal GABA transporter by various anticonvulsant drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Binding Sites; Biological Transport; Carrier Proteins; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Electric Conductivity; Female; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Mice; Nipecotic Acids; Oocytes; Organic Anion Transporters; Patch-Clamp Techniques; Tiagabine; Valproic Acid; Vigabatrin; Xenopus laevis | 1999 |
Activity-dependent enhancement of hyperpolarizing and depolarizing gamma-aminobutyric acid (GABA) synaptic responses following inhibition of GABA uptake by tiagabine.
Topics: Animals; Anticonvulsants; Electric Stimulation; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Interneurons; Male; Neural Inhibition; Nipecotic Acids; Rats; Rats, Sprague-Dawley; Reaction Time; Synapses; Synaptic Transmission; Tiagabine | 1999 |
Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antioxidants; Cell Membrane Permeability; Chlorides; Chromans; Deferoxamine; Extracellular Space; Fluorescent Dyes; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hydrogen Peroxide; In Vitro Techniques; Kinetics; Microscopy, Confocal; Muscimol; Nipecotic Acids; Oxidative Stress; Pyramidal Cells; Quinolinium Compounds; Quinoxalines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tiagabine | 1999 |
Inhibition of [3H]D-aspartate release by deramciclane.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Aspartic Acid; Camphanes; Cell Membrane; Cerebral Cortex; Depression, Chemical; Excitatory Amino Acid Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Male; Nerve Endings; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Wistar; Receptors, GABA-A; Tiagabine | 1999 |
Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat.
Topics: Animals; Carrier Proteins; Electroencephalography; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Prosencephalon; Rats; Stereoisomerism; Synaptosomes; Tiagabine | 1999 |
GABA transporters (GAT-1) in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain Chemistry; Carrier Proteins; Caudate Nucleus; Female; Frontal Lobe; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Male; Membrane Proteins; Membrane Transport Proteins; Neurites; Nipecotic Acids; Organic Anion Transporters; Temporal Lobe; Tiagabine; Tritium | 1999 |
Refractory epilepsy: treatment with new antiepileptic drugs.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Resistance; Drug Therapy, Combination; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Middle Aged; Nipecotic Acids; Patient Dropouts; Retrospective Studies; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin | 2000 |
Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze.
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Carrier Proteins; Dose-Response Relationship, Drug; Environment; Exploratory Behavior; GABA Agents; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Male; Membrane Proteins; Membrane Transport Proteins; Motor Activity; Nipecotic Acids; Organic Anion Transporters; Rats; Tiagabine | 1999 |
Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels.
Topics: Amygdala; Animals; Anticonvulsants; Brain Chemistry; Electroencephalography; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Wistar; Tiagabine | 2000 |
Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue.
Topics: Adult; Anticonvulsants; Astrocytes; Carrier Proteins; Cells, Cultured; Female; Fetus; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Membrane Proteins; Membrane Transport Proteins; Neural Inhibition; Nipecotic Acids; Organic Anion Transporters; Pregnancy; Pregnancy Trimester, Second; Temporal Lobe; Tiagabine; Valproic Acid; Vigabatrin | 1999 |
GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.
Topics: Acoustic Stimulation; Anesthesia; Animals; Anisoles; Anticonvulsants; Carbazoles; Chromatography, High Pressure Liquid; Convulsants; Electroshock; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Mice; Mice, Inbred DBA; Microdialysis; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Pentylenetetrazole; Piperidines; Seizures; Substantia Nigra; Thalamus; Tiagabine | 2000 |
Different effects of GABAergic anticonvulsants on 4-aminopyridine-induced spontaneous GABAergic hyperpolarizations of hippocampal pyramidal cells--implication for their potency in migraine therapy.
Topics: 4-Aminopyridine; Acetates; Amines; Analgesics; Animals; Anticonvulsants; Convulsants; Cyclohexanecarboxylic Acids; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Humans; Membrane Potentials; Migraine Disorders; Nipecotic Acids; Pyramidal Cells; Tiagabine; Time Factors; Valproic Acid; Vigabatrin | 2000 |
[Clinical utilization of new anti-epileptic agents].
Topics: Acetates; Amines; Anemia, Aplastic; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Drug Tolerance; Epilepsy; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Phenylcarbamates; Piracetam; Propylene Glycols; Tiagabine; Topiramate; Triazines; Vigabatrin; Visual Fields | 2000 |
Pharmacokinetic-pharmacodynamic modelling of tiagabine CNS effects upon chronic treatment in rats: lack of change in concentration-EEG effect relationship.
Topics: Animals; Anticonvulsants; Beta Rhythm; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; gamma-Aminobutyric Acid; Kinetics; Male; Models, Theoretical; Nipecotic Acids; Placebos; Rats; Rats, Wistar; Regression Analysis; Tiagabine | 2000 |
Localization and pharmacological characterization of voltage dependent calcium channels in cultured neocortical neurons.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Carrier Proteins; Cells, Cultured; Chelating Agents; Cytosol; Female; Fetus; Fura-2; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Membrane Proteins; Membrane Transport Proteins; Mice; Neocortex; Neurons; Nipecotic Acids; Organic Anion Transporters; Potassium; Presynaptic Terminals; Sodium Channels; Synaptic Vesicles; Tetrodotoxin; Tiagabine | 2001 |
Efficacy of background GABA uptake in rat hippocampal slices.
Topics: Animals; Carrier Proteins; Electric Conductivity; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Membrane Proteins; Membrane Transport Proteins; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Patch-Clamp Techniques; Pyramidal Cells; Rats; Tiagabine | 2001 |
Effects of antiepileptic drugs on cognition.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; Triazoles; Vigabatrin | 2001 |
Management strategies for refractory localization-related seizures.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Nipecotic Acids; Practice Patterns, Physicians'; Tiagabine; Topiramate; Treatment Outcome; Triazines; Vigabatrin | 2001 |
Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model.
Topics: Acetates; Amines; Animals; Cyclohexanecarboxylic Acids; Deafness; Diagnosis, Differential; Disease Models, Animal; Ear; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Male; Nipecotic Acids; Noise; Pitch Perception; Psychophysics; Rats; Rats, Long-Evans; Tiagabine; Tinnitus; Wounds and Injuries | 2001 |
Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1.
Topics: Aminobutyrates; Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression; Humans; Kidney; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Ouabain; Rats; Receptors, GABA; Tiagabine; Tritium | 2002 |
Increased [(3)H]tiagabine binding to GAT-1 in the cingulate cortex in schizophrenia.
Topics: Aged; Aged, 80 and over; Brain; Carrier Proteins; Case-Control Studies; Caudate Nucleus; Chronic Disease; Female; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gyrus Cinguli; Humans; In Vitro Techniques; Male; Membrane Proteins; Membrane Transport Proteins; Middle Aged; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Schizophrenia; Tiagabine; Up-Regulation | 2002 |
[Adult GM2 gangliosidosis: improvement of ataxia with GABAergic drugs].
Topics: Acetates; Adult; Amines; Ataxia; beta-N-Acetylhexosaminidases; Cerebellum; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Gangliosidoses, GM2; Humans; Male; Myokymia; Nipecotic Acids; Tiagabine; Tomography, X-Ray Computed | 2002 |
Recurrent complex partial status epilepticus associated with tiagabine rechallenge.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; Humans; Lorazepam; Male; Meningoencephalitis; Nipecotic Acids; Status Epilepticus; Tiagabine; Treatment Outcome | 2002 |
Neuroprotective effect of tiagabine in transient forebrain global ischemia: an in vivo microdialysis, behavioral, and histological study.
Topics: Animals; Behavior, Animal; Body Temperature; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gerbillinae; Injections, Intraperitoneal; Ischemic Attack, Transient; Male; Maze Learning; Memory; Memory, Short-Term; Microdialysis; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Tiagabine | 2002 |
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception.
Topics: Acetates; Acute Disease; Adrenergic alpha-Agonists; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Dynorphins; Formaldehyde; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Injections, Intraperitoneal; Injections, Spinal; Lamotrigine; Male; Mice; Mice, Inbred ICR; Nipecotic Acids; Pain; Pain Measurement; Reaction Time; Tiagabine; Triazines | 2002 |
The 'number needed to treat' with levetiracetam (LEV): comparison with the other new antiepileptic drugs (AEDs).
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Epilepsies, Partial; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; Vigabatrin; Zonisamide | 2002 |
Pre- rather than co-application of vigabatrin increases the efficacy of tiagabine in hippocampal slices.
Topics: Animals; Anticonvulsants; Culture Techniques; Drug Synergism; Evoked Potentials; gamma-Aminobutyric Acid; Guinea Pigs; Hippocampus; Kindling, Neurologic; Magnesium; Nipecotic Acids; Premedication; Tiagabine; Vigabatrin | 2002 |
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; Chlordiazepoxide; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glucose; Hippocampus; Hypoxia; Ischemia; Lamotrigine; Levetiracetam; Midazolam; Neurons; Neuroprotective Agents; Nipecotic Acids; Oxcarbazepine; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Rats; Rats, Wistar; Tiagabine; Triazines; Valproic Acid | 2003 |
Unaltered control of extracellular GABA-concentration through GAT-1 in the hippocampus of rats after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Muscarinic Agonists; Nipecotic Acids; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus; Tiagabine | 2003 |
Altered gene expression in frontal cortex and midbrain of 3,4-methylenedioxymethamphetamine (MDMA) treated mice: differential regulation of GABA transporter subtypes.
Topics: Animals; Carrier Proteins; Cloning, Molecular; Frontal Lobe; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation; Male; Membrane Proteins; Membrane Transport Proteins; Mesencephalon; Mice; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Nipecotic Acids; Organic Anion Transporters; Oximes; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Tiagabine | 2003 |
Tiagabine synergistically interacts with gabapentin in the electroconvulsive threshold test in mice.
Topics: Acetates; Amines; Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Cyclohexanecarboxylic Acids; Differential Threshold; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Memory; Mice; Motor Activity; Nipecotic Acids; Pain Threshold; Psychomotor Performance; Reaction Time; Tiagabine | 2003 |
[Clinical and neurochemical aspects of diaphragmatic myoclonus].
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Diaphragm; Female; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Myoclonus; Nipecotic Acids; Tiagabine | 2003 |
Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain Ischemia; Carrier Proteins; Cerebral Cortex; Corpus Striatum; Electric Stimulation; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Organic Anion Transporters; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Synaptic Transmission; Tiagabine; Vigabatrin | 2004 |
Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study.
Topics: Amines; Animals; Anticonvulsants; Convulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Seizures; Tiagabine | 2004 |
Interaction between anticonvulsants and human placental carnitine transporter.
Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techniques; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Models, Biological; Nipecotic Acids; Organic Cation Transport Proteins; Phenytoin; Placenta; Pregnancy; Pregnancy Complications; Pregnancy Proteins; Solute Carrier Family 22 Member 5; Tiagabine; Topiramate; Triazines; Valproic Acid; Vigabatrin | 2004 |
Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.
Topics: Acute Disease; Animals; Anticonvulsants; Darkness; gamma-Aminobutyric Acid; Light; Male; Nipecotic Acids; Photic Stimulation; Photoreceptor Cells; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Scotoma; Tiagabine; Vigabatrin; Vision Disorders; Visual Fields | 2004 |
Acute administration of the GABA reuptake inhibitor tiagabine does not alter the effects of oral cocaine in humans.
Topics: Administration, Oral; Adult; Analysis of Variance; Cocaine; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Combinations; gamma-Aminobutyric Acid; Humans; Middle Aged; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Tiagabine | 2004 |
Behavioural correlates of an altered balance between synaptic and extrasynaptic GABAAergic inhibition in a mouse model.
Topics: Animals; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Neural Inhibition; Nipecotic Acids; Protein Binding; Receptors, GABA-A; Reflex, Startle; Seizures; Synapses; Tiagabine | 2004 |
GABA transporters as drug targets for modulation of GABAergic activity.
Topics: Animals; Anticonvulsants; Astrocytes; Biological Transport; Drug Delivery Systems; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Membrane Transport Proteins; Mice; Molecular Conformation; Neurons; Nipecotic Acids; Tiagabine | 2004 |
[Progressive encephalomyelitis with rigidity responsive to gabapentin: a pharmacological update].
Topics: Amines; Antiparkinson Agents; Clonidine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Encephalomyelitis; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Immunoglobulins, Intravenous; Muscle Rigidity; Nipecotic Acids; Tiagabine | 2004 |
[New molecular targets in pharmacological treatment of anxiety disorders].
Topics: Anxiety Disorders; Benzodiazepines; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Molecular Biology; Nipecotic Acids; Pregabalin; Receptors, GABA; Tiagabine | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Cloning, Molecular; Convulsants; Drug Synergism; Epilepsy; Epilepsy, Reflex; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Mice; N-Acetylglucosaminyltransferases; Neurons; Nipecotic Acids; Pentylenetetrazole; Pilocarpine; Psychomotor Disorders; Recombinant Proteins; Seizures; Tiagabine | 2005 |
Antiepileptic action induced by a combination of vigabatrin and tiagabine.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Electric Stimulation; Evoked Potentials; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Magnesium; Mice; Nipecotic Acids; Oocytes; Patch-Clamp Techniques; Potassium Chloride; Seizures; Tiagabine; Time Factors; Vigabatrin; Xenopus laevis | 2005 |
Tiagabine for rage, aggression, and anxiety.
Topics: Adolescent; Adult; Aggression; Anxiety; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rage; Retrospective Studies; Tiagabine | 2005 |
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Nipecotic Acids; Oxcarbazepine; Pentylenetetrazole; Seizures; Tiagabine | 2005 |
Design, synthesis, and biological evaluation of the N-diarylalkenyl-piperidinecarboxylic acid derivatives as GABA uptake inhibitors (I).
Topics: Animals; Biological Transport; Carboxylic Acids; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; GABA Agonists; gamma-Aminobutyric Acid; Humans; Inhibitory Concentration 50; Models, Chemical; Neurons; Nipecotic Acids; Pipecolic Acids; Structure-Activity Relationship; Tiagabine | 2006 |
Depression of extra-cellular GABA and increase of NMDA-induced nitric oxide following acute intra-nuclear administration of alcohol in the cerebellar nuclei of the rat.
Topics: Animals; Central Nervous System Depressants; Cerebellar Nuclei; Enzyme Inhibitors; Ethanol; Excitatory Amino Acid Antagonists; Extracellular Fluid; GABA Agonists; gamma-Aminobutyric Acid; Indazoles; Injections, Intraventricular; Male; Microdialysis; N-Methylaspartate; Nipecotic Acids; Nitric Oxide; Quinoxalines; Rats; Rats, Wistar; Tiagabine; Valine | 2005 |
Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization.
Topics: Amines; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Cyclohexanecarboxylic Acids; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agents; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Male; Motor Activity; Nipecotic Acids; Rats; Rats, Wistar; Tiagabine; Vigabatrin | 2006 |
[Adult-onset ataxia-telangiectasia. A clinical and therapeutic observation].
Topics: Adolescent; Adult; Ataxia Telangiectasia; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Male; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Tiagabine | 2006 |
Effect of the administration of tiagabine and gabapentin on rabbit electroencephalogram activity.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Electroencephalography; Female; Frontal Lobe; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; Male; Metencephalon; Nipecotic Acids; Rabbits; Tiagabine | 2006 |
Altered cortico-striatal synaptic plasticity and related behavioural impairments in reeler mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Neuronal Plasticity; Neurons; Nipecotic Acids; Parvalbumins; Probability; Reelin Protein; Synapses; Tiagabine | 2006 |
High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study.
Topics: 4-Aminobutyrate Transaminase; Animals; Citric Acid Cycle; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Nipecotic Acids; Prosencephalon; Proteolipids; Swine; Tiagabine | 2007 |
Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons.
Topics: Animals; Appetitive Behavior; Baclofen; Cocaine-Related Disorders; GABA Antagonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Male; Motivation; Nipecotic Acids; Organophosphonates; Papio anubis; Phosphinic Acids; Self Administration; Tiagabine | 2007 |
Diverse effects of GABA-mimetic drugs on cocaine-evoked self-administration and discriminative stimulus effects in rats.
Topics: Amines; Animals; Behavior, Animal; Cocaine; Cyclohexanecarboxylic Acids; Discrimination Learning; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Male; Nipecotic Acids; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration; Tiagabine; Vigabatrin | 2007 |
Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAG/Rij rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Absence; gamma-Aminobutyric Acid; Hippocampus; Male; Microinjections; Neural Inhibition; Nipecotic Acids; Progesterone; Rats; Rats, Inbred Strains; Synaptic Transmission; Tiagabine | 2007 |
New therapies for ataxia-telangiectasia.
Topics: Adult; Anticonvulsants; Ataxia Telangiectasia; Drug Therapy, Combination; Gait; gamma-Aminobutyric Acid; Humans; Male; Nipecotic Acids; Pregabalin; Tiagabine; Treatment Outcome; Walking | 2007 |
Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors.
Topics: Animals; Anticonvulsants; Carboxylic Acids; Chemistry, Pharmaceutical; Drug Design; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Imidazoles; Inhibitory Concentration 50; Mice; Models, Chemical; Nipecotic Acids; Piperidines; Structure-Activity Relationship; Temperature; Tiagabine | 2007 |
Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1.
Topics: Animals; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Homeostasis; Hypnotics and Sedatives; Inhibitory Postsynaptic Potentials; Mice; Neuronal Plasticity; Nipecotic Acids; Pentobarbital; Reaction Time; Synaptic Transmission; Tiagabine | 2007 |
Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.
Topics: Administration, Oral; Amines; Animals; Anticonvulsants; Azabicyclo Compounds; Baclofen; Benzodiazepines; Bicuculline; Brain; Cyclohexanecarboxylic Acids; Discrimination Learning; Dose-Response Relationship, Drug; GABA Agents; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; Gabapentin; gamma-Aminobutyric Acid; Generalization, Stimulus; Hypnotics and Sedatives; Injections, Intraperitoneal; Isoxazoles; Male; Nipecotic Acids; Piperazines; Pyridines; Rats; Thiophenes; Tiagabine; Zolpidem | 2008 |
Metabolism of [1,6-(13)C]glucose and [U-(13)C]glutamine and depolarization induced GABA release in superfused mouse cerebral cortical mini-slices.
Topics: Amino Acids; Animals; Carbon Isotopes; Cerebral Cortex; Cobalt; GABA Agonists; gamma-Aminobutyric Acid; Glucose; Glutamine; Homeostasis; Mice; Nipecotic Acids; Tiagabine | 2008 |
Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects.
Topics: Adult; Brain Mapping; Cerebral Cortex; Cognition; Cortical Synchronization; Feasibility Studies; Female; Flumazenil; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Positron-Emission Tomography; Receptors, GABA-A; Tiagabine | 2009 |
Retention rates of new antiepileptic drugs in localization-related epilepsy: a single-center study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Epilepsy; Female; Finland; Fructose; Gabapentin; gamma-Aminobutyric Acid; Half-Life; Humans; Lamotrigine; Levetiracetam; Licensure, Pharmacy; Male; Middle Aged; Nipecotic Acids; Piracetam; Retrospective Studies; Tiagabine; Topiramate; Treatment Outcome; Triazines; Young Adult | 2009 |
Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: an isobolographic analysis.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Formaldehyde; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Nipecotic Acids; Pain Measurement; Psychomotor Performance; Tiagabine | 2009 |
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Interactions; Drug Synergism; Gabapentin; gamma-Aminobutyric Acid; Levetiracetam; Male; Mice; Nipecotic Acids; Pentylenetetrazole; Piracetam; Seizures; Tiagabine; Tissue Distribution; Vigabatrin | 2009 |
Loss of GABAergic interneurons in laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain after spinal cord injury.
Topics: Animals; Apoptosis; Caspase 3; Cell Count; Disease Models, Animal; Down-Regulation; GABA Agonists; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; Interneurons; Male; Mice; Mice, Transgenic; Nerve Degeneration; Neural Inhibition; Neuralgia; Nipecotic Acids; Pain Measurement; Pain Threshold; Posterior Horn Cells; Promoter Regions, Genetic; Spinal Cord Injuries; Tiagabine | 2010 |
Intrinsic activation of GABA(A) receptors suppresses epileptiform activity in the cerebral cortex of immature mice.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Anisoles; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; In Vitro Techniques; Magnesium; Mice; Mice, Inbred C57BL; Nipecotic Acids; Patch-Clamp Techniques; Potassium Channel Blockers; Pyridazines; Receptors, GABA-A; Tiagabine | 2010 |
A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures.
Topics: Animals; Betaine; Cells, Cultured; Cerebellum; GABA Agents; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Lipotropic Agents; Mice; Neurons; Nipecotic Acids; Tiagabine; Vesicular Glutamate Transport Protein 1 | 2010 |
An historical perspective on GABAergic drugs.
Topics: 4-Aminobutyrate Transaminase; Animals; Benzodiazepines; Bestrophins; Chloride Channels; Eye Proteins; GABA Agonists; GABA Antagonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Molecular Structure; Nipecotic Acids; Receptors, GABA-A; Receptors, GABA-B; Synapses; Tiagabine | 2011 |
[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels.
Topics: Adult; Carbon Isotopes; Cognition; Dose-Response Relationship, Drug; Electroencephalography; Electrophysiology; Female; Flumazenil; GABA Modulators; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Ligands; Male; Models, Statistical; Nipecotic Acids; Positron-Emission Tomography; Regression Analysis; Tiagabine | 2012 |
A steered molecular dynamics study of binding and translocation processes in the GABA transporter.
Topics: Anticonvulsants; Binding Sites; Cytoplasm; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Nipecotic Acids; Protein Binding; Protein Conformation; Tiagabine | 2012 |
Elevating endogenous GABA levels with GAT-1 blockade modulates evoked but not induced responses in human visual cortex.
Topics: Adult; Evoked Potentials, Visual; Female; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Magnetoencephalography; Male; Nipecotic Acids; Photic Stimulation; Tiagabine; Visual Cortex; Young Adult | 2013 |
Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Synergism; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Female; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NAV1.1 Voltage-Gated Sodium Channel; Nipecotic Acids; Postural Balance; Seizures; Synaptic Transmission; Tiagabine | 2013 |
Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons.
Topics: Animals; Animals, Newborn; Axons; Cholecystokinin; Computer Simulation; Dendrites; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Agents; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Interneurons; Male; Models, Neurological; Neural Inhibition; Neuropeptide Y; Nipecotic Acids; Parvalbumins; Rats; Rats, Transgenic; Rats, Wistar; Receptors, GABA-B; Tiagabine; Vesicular Inhibitory Amino Acid Transport Proteins | 2013 |
GABAergic tonic inhibition is regulated by developmental age and epilepsy in the dentate gyrus.
Topics: Aging; Animals; Anticonvulsants; Data Interpretation, Statistical; Dentate Gyrus; Diazepam; Electrophysiological Phenomena; Epilepsy; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Nipecotic Acids; Patch-Clamp Techniques; Rats; Rats, Wistar; Status Epilepticus; Tiagabine | 2013 |
GABA and glutamate pathways are spatially and developmentally affected in the brain of Mecp2-deficient mice.
Topics: Animals; Blotting, Western; Brain; Cells, Cultured; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Glutamic Acid; Male; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Nipecotic Acids; Real-Time Polymerase Chain Reaction; Rett Syndrome; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Synaptic Transmission; Tiagabine | 2014 |
Measurement of GABA using J-difference edited 1H-MRS following modulation of synaptic GABA concentration with tiagabine.
Topics: Adult; Brain; Extracellular Space; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Proton Magnetic Resonance Spectroscopy; Synapses; Tiagabine; Young Adult | 2014 |
Tiagabine improves hippocampal long-term depression in rat pups subjected to prenatal inflammation.
Topics: Animals; Child Development Disorders, Pervasive; Female; GABAergic Neurons; gamma-Aminobutyric Acid; Hippocampus; Humans; Inflammation; Lipopolysaccharides; Male; Neuronal Plasticity; Nipecotic Acids; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Schizophrenia; Tiagabine | 2014 |
Influence of agonist induced internalization on [3H]Ro15-4513 binding-an application to imaging fluctuations in endogenous GABA with positron emission tomography.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Carbon Radioisotopes; Cell Membrane; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Positron-Emission Tomography; Radiopharmaceuticals; Rats, Sprague-Dawley; Receptors, GABA-A; Tiagabine; Tritium | 2015 |
Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases.
Topics: Amines; Anticonvulsants; Carbamazepine; Chromatography, Liquid; Cyclohexanecarboxylic Acids; Drug Monitoring; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Limit of Detection; Nipecotic Acids; Oxcarbazepine; Phenytoin; Piracetam; Pregabalin; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tiagabine; Topiramate; Triazines; Valproic Acid | 2014 |
Effects of γ-Aminobutyric acid transporter 1 inhibition by tiagabine on brain glutamate and γ-Aminobutyric acid metabolism in the anesthetized rat In vivo.
Topics: Anesthesia; Animals; Blood Glucose; Brain; Carbon Isotopes; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Male; Neurons; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Rats; Rats, Wistar; Tiagabine | 2015 |
A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1).
Topics: Computer Simulation; GABA Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; HEK293 Cells; High-Throughput Screening Assays; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Nipecotic Acids; Structure-Activity Relationship; Tiagabine; Triiodothyronine | 2015 |
GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury.
Topics: Action Potentials; Animals; Animals, Newborn; Asphyxia Neonatorum; Carbachol; Cell Count; Cells, Cultured; Cerebellum; Demyelinating Diseases; Disease Models, Animal; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypoxia, Brain; Interneurons; Male; Mice; Mice, Knockout; Mice, Transgenic; Neural Stem Cells; Neurogenesis; Nipecotic Acids; Oligodendroglia; Purkinje Cells; Receptors, GABA-A; Solute Carrier Family 12, Member 2; Tiagabine; Vigabatrin; White Matter | 2015 |
The effect of tiagabine on physical development and neurological reflexes and their relationship with the γ-aminobutyric acid switch in the rat cerebral cortex during developmental stages.
Topics: Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Cerebral Cortex; Down-Regulation; Female; GABA Agonists; gamma-Aminobutyric Acid; K Cl- Cotransporters; Nipecotic Acids; Rats; Rats, Wistar; Reflex; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Symporters; Tiagabine | 2013 |
In vivo measurement of GABA transmission in healthy subjects and schizophrenia patients.
Topics: Adult; Carbon Radioisotopes; Case-Control Studies; Cerebral Cortex; Female; Flumazenil; GABA Modulators; GABA Plasma Membrane Transport Proteins; Gamma Rhythm; gamma-Aminobutyric Acid; Humans; Male; Neuropsychological Tests; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Positron-Emission Tomography; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission; Temporal Lobe; Tiagabine; Young Adult | 2015 |
Significant reductions in human visual gamma frequency by the gaba reuptake inhibitor tiagabine revealed by robust peak frequency estimation.
Topics: Alcohol Drinking; Brain; Central Nervous System Depressants; Computer Simulation; Cross-Over Studies; Ethanol; GABA Uptake Inhibitors; Gamma Rhythm; gamma-Aminobutyric Acid; Humans; Magnetoencephalography; Models, Neurological; Nipecotic Acids; Single-Blind Method; Tiagabine; Visual Perception | 2016 |
GAT-1 mediated GABA uptake in rat oligodendrocytes.
Topics: Animals; Animals, Newborn; Antigens; Brain; Cells, Cultured; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Male; Microscopy, Confocal; Microscopy, Immunoelectron; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oligodendroglia; Optic Nerve; Proteoglycans; Rats; Rats, Sprague-Dawley; Receptor-Interacting Protein Serine-Threonine Kinases; Sodium; Tiagabine; Tritium | 2017 |
Molecular Dynamic Simulations to Probe Stereoselectivity of Tiagabine Binding with Human GAT1.
Topics: GABA Agents; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Molecular Dynamics Simulation; Protein Binding; Stereoisomerism; Tiagabine | 2020 |
Tiagabine induced modulation of oscillatory connectivity and activity match PET-derived, canonical GABA-A receptor distributions.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Mammals; Nipecotic Acids; Positron-Emission Tomography; Receptors, GABA; Receptors, GABA-A; Tiagabine | 2021 |
Structural basis of GABA reuptake inhibition.
Topics: Anticonvulsants; Cryoelectron Microscopy; GABA Plasma Membrane Transport Proteins; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Humans; Neurotransmitter Agents; Protein Conformation; Tiagabine | 2022 |
GABA transport goes structural.
Topics: Anticonvulsants; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Tiagabine | 2023 |
Molecular basis for substrate recognition and transport of human GABA transporter GAT1.
Topics: GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Molecular Conformation; Tiagabine | 2023 |