thymine glycol has been researched along with thymine in 182 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 38 (20.88) | 18.7374 |
1990's | 49 (26.92) | 18.2507 |
2000's | 56 (30.77) | 29.6817 |
2010's | 31 (17.03) | 24.3611 |
2020's | 8 (4.40) | 2.80 |
Authors | Studies |
---|---|
Hill, GJ; Hill, HZ; Hubbard-Smith, K | 1 |
Bergtold, DS; Karam, LR; Simic, MG | 1 |
Carlson, EJ; Epstein, CJ; Huang, TT; Leadon, SA | 1 |
Soderlind, KJ; Weinfeld, M | 1 |
Krause, GS; O'Neil, BJ; White, BC | 1 |
Blackburn, GR; Bleicher, WT; Reddy, MV | 1 |
Basu, AK; Benasutti, M; Essigmann, JM; Green, CL; Loechler, EL | 1 |
Schuchmann, HP; von Sonntag, C | 1 |
Leadon, SA | 2 |
Duker, NJ; Ganguly, T; Weems, KM | 1 |
Hegi, ME; Lutz, WK; Richter, C; Sagelsdorff, P; Ulrich, D | 1 |
Kow, YW; Van Houten, B; Wallace, SS | 1 |
Doetsch, PW; Lee, K; McCray, WH | 1 |
Laspia, MF; Wallace, SS | 2 |
Erlanger, BF; Huang, H; Hubbard, K; Ide, H; Laspia, MF; Wallace, SS | 1 |
Basu, AK; Essigmann, JM; Loechler, EL | 1 |
Wallace, SS | 3 |
Basu, AK; Essigmann, JM; Leadon, SA; Loechler, EL | 1 |
Lin, JJ; Sancar, A | 1 |
Beardsley, GP; Clark, JM | 3 |
Ganesan, AK; Hanawalt, PC; Leadon, SA; Meade, S; Spivak, G; Vos, JM | 1 |
Chan, A; Leadon, SA; Zimmerman, RJ | 1 |
Claycamp, HG; Smith, ST | 1 |
Smith, CA | 1 |
Adelman, R; Ames, BN; Saul, RL | 1 |
Alessio, H; Bergtold, DS; Cutler, RG; Simic, MG | 1 |
Ito, T; Kaneko, M; Leadon, SA | 1 |
Hayes, RC; Huang, HM; LeClerc, JE; Petrullo, LA; Wallace, SS | 1 |
Claycamp, HG | 1 |
Beardsley, GP; Clark, JM; Jarvis, W; Pattabiraman, N | 1 |
Schellenberg, KA; Shaeffer, J | 1 |
Essigmann, JM; Rouet, P | 1 |
Ide, H; Kow, YW; Wallace, SS | 1 |
Kaneko, M; Leadon, SA | 1 |
Hayes, RC; LeClerc, JE | 1 |
Ames, BN | 1 |
Ames, BN; Cathcart, R; Saul, RL; Schwiers, E | 1 |
Ide, H; Kagiya, T; Nishimoto, S; Wada, T | 1 |
Erlanger, BF; Laspia, MF; Melamede, RJ; Rajagopalan, R; Wallace, SS | 1 |
Hanawalt, PC; Leadon, SA | 1 |
Duker, NJ; Frenkel, K; Goldstein, MS; Teebor, GW | 1 |
Ward, JF; West, GJ; West, IW | 1 |
Frenkel, K; Goldstein, MS; Teebor, GW | 1 |
Hariharan, PV | 1 |
Barbee, SL; Dunn, AB; Leadon, SA | 1 |
Bockrath, R; Courcelle, J; Evans, J; Hatahet, Z; Ide, H; Maccabee, M; Wallace, S | 1 |
Miaskiewicz, K; Miller, J; Ornstein, R; Osman, R | 1 |
Fuciarelli, AF; Miller, DL; Sisk, EC; Thomas, RM | 1 |
Augeri, L; Doetsch, PW; Hamilton, KK; Martin, AM; Yohannes, P | 1 |
Ho, YS; Lin, JK; Lo, MJ; Wang, YJ | 1 |
Miaskiewicz, K; Miller, J; Osman, R | 1 |
Del Rowe, J; Franklin, WA; Minton, KW; Mun, C; Sandigursky, M | 1 |
Claycamp, HG; Luo, D | 1 |
Cao, EH; Wang, JJ | 1 |
Bolton, PH; Goljer, I; Kao, JY; Phan, TA | 1 |
Claycamp, HG; Huang, H | 1 |
Markey, CJ; Markey, SP; Wang, TC | 1 |
Bolton, PH; Boorstein, RJ; Cunningham, RP; Hilbert, TP; Kung, HC; Teebor, GW; Xing, D | 1 |
Ichikawa, N; Nagao, T; Tomikawa, S; Uchida, H; Watanabe, K | 1 |
Daniel, LN; Mao, Y; Markey, CJ; Markey, SP; Saffiotti, U; Shi, X; Wang, TC | 1 |
Anselmino, C; Lindahl, T; Roldán-Arjona, T | 1 |
Bolton, PH; Kung, HC | 1 |
Avrutskaya, AV; Leadon, SA | 2 |
Allalunis-Turner, J; Chen, D; Karimi-Busheri, F; Lee, J; Ruiqi, G; Weinfeld, M | 1 |
Ambulos, NP; Friedberg, EC; Malanoski, G; Radany, EH; Yasbin, RE | 1 |
Bolton, PH; Jerkovic, B; Kung, HC | 1 |
Bailey, E; Farmer, PB; Farooq, S; Hernández, H; Jukes, R; Lamb, JH; Sram, R; Topinka, J | 1 |
Bond, JP; Hatahet, Z; Lampman, GW; Purmal, AA; Wallace, SS | 1 |
Le, XC; Leadon, SA; Lee, J; Weinfeld, M; Xing, JZ | 2 |
Peters, R; Sikorski, R | 1 |
Basu, AK; Bolton, PH; Jerkovic, B; McNulty, JM | 1 |
Halliwell, B; Ince, PG; Jenner, A; Jenner, P; Lyras, L; Perry, EK; Perry, RH | 1 |
Avrutskaya, AV; Gowen, LC; Koller, BH; Latour, AM; Leadon, SA | 1 |
Akiyama, K; Bo, Z; Ide, H; Ikeda, S; Imai, K; Kubo, K; Nakano, H; Sarker, AH; Seki, S; Terato, H; Tsutsui, K; Yamamoto, K; Yasui, A; Yoshida, MC | 1 |
Buckley, TJ; Dizdaroglu, M; Karahalil, B; Roldán-Arjona, T; Sentürker, S | 1 |
Cadet, J; D'Ham, C; Gasparutto, D; Jaquinod, M; Romieu, A | 1 |
Alseth, I; Bjørås, M; Eide, L; Pirovano, M; Rognes, T; Seeberg, E | 1 |
Morimyo, M; Yasuhira, S; Yasui, A | 1 |
Funabiki, R; Miura, Y; Nagasawa, T; Shibasato, M; Takeshita, K | 1 |
Box, HC; Budzinski, EE; Dawidzik, JB; Ersing, N; Freund, HG; Iijima, H; Maccubbin, AE; Patrzyc, HB; Wallace, JC | 1 |
Bohr, VA; Dianov, GL; Dianova, II; Lipinski, LJ; Thybo, T | 1 |
Asagoshi, K; Asgarani, E; Ide, H; Ohyama, Y; Saito, T; Shahmohammadi, HR; Terato, H; Yamamoto, O | 1 |
Asagoshi, K; Ide, H; Miyano, T; Nakano, H; Odawara, H; Ohyama, Y; Seki, S; Terato, H | 1 |
Fujikawa, K; Kasai, H | 1 |
Okano, S; Yasui, A | 1 |
Cooper, PK; Lobrich, M; Rydberg, B | 1 |
Cooper, PK; Le, XC; Leadon, SA; Lee, J; Weinfeld, M; Xing, JZ | 1 |
Bentele, M; Hardeland, U; Jiricny, J; Lettieri, T; Schär, P; Steinacher, R | 1 |
Bohr, VA; Dianov, GL; Nyaga, SG; Souza-Pinto, N; Stevnsner, T; Thybo, T | 1 |
Aas, PA; Akbari, M; Andersen, S; Kavli, B; Krokan, HE; Nilsen, H; Otterlei, M; Skjelbred, C; Skorpen, F; Slupphaug, G | 1 |
Hanawalt, PC; Lloyd, DR; Maeda, LS; Reines, D; Tornaletti, S | 1 |
Bowman, KJ; Farmer, PB; Guichard, Y; Jones, GD; Pla, RL | 1 |
Iwai, S | 2 |
Burgess, S; Dizdaroglu, M; Dodson, ML; Jaruga, P; Lloyd, RS | 1 |
Bohr, VA; Brosh, RM; Christiansen, M; Citterio, E; May, A; Muftuoglu, M; Nyaga, S; Selzer, RR; Tuo, J | 1 |
Hanaoka, F; Iwai, S; Kusumoto, R; Masutani, C | 1 |
Wang, Y | 1 |
Hasegawa, R; Hoeijmakers, JH; Ide, H; Ikeda, S; Kanno, S; Kobayashi, K; Le, XC; Miyazaki, J; Muijtjens, M; Sarker, AH; Seki, S; Shiromoto, T; Takao, M; van der Horst, G; Weinfeld, M; Xing, JZ; Yasui, A | 1 |
Brooks, K; Miller, AC; Page, N; Shi, L; Stewart, M | 1 |
Feaver, WJ; Fischhaber, PL; Friedberg, EC; Gerlach, VL; Hatahet, Z; Wallace, SS | 1 |
Alanazi, M; Leadon, SA; Mellon, I | 1 |
Johnson, RE; Prakash, L; Prakash, S; Yu, SL | 1 |
Budworth, H; Dianov, GL | 1 |
Back, JH; Chung, JH; Han, YS; Kim, KS; Park, YI | 1 |
Hasegawa, A; Hoshino, M; Mizoi, M; Okada, S; Tachikawa, M; Yamanaka, K | 1 |
Iwai, S; O'Connor, TR; Pfeifer, GP; Yoon, JH | 1 |
Fernandes, AS; Grollman, AP; Iden, CR; McTigue, MM; Miller, H; Torres, MC; Wente, M; Zaika, E | 1 |
Kathe, SD; Shen, GP; Wallace, SS | 1 |
De Los Santos, CR; Iden, CR; McTigue, MM; Rieger, RA; Rosenquist, TA | 1 |
An, Y; Hoshino, M; Kato, K; Mizoi, M; Nakano, M; Okada, S; Takabayashi, F; Yamanaka, K | 1 |
Wang, Y; Zhang, Q | 1 |
Bahar, I; Iwai, S; Masutani, C; Schuffert, A; Seki, M; Wood, RD; Yang, LW | 1 |
Sugiyama, H; Takao, M; Yasui, A; Yonei, S; Yonekura, S; Zhang, QM | 1 |
Chaudhry, MA; Wallace, SS; Yang, N | 1 |
Hanawalt, PC; Spivak, G | 1 |
Iwai, S; Kawasaki, Y; Manabe, K; Shimizu, T; Yoshikawa, S | 1 |
Altamirano, A; Basu, AK; Boorstein, RJ; Chan, MK; Cummings, A; Cunningham, RP; Ocampo, JE; Ocampo-Hafalla, MT; Teebor, GW | 1 |
Bailey, DT; Box, HC; Budzinski, EE; Dawidzik, JB; DeFedericis, HC; Greene, KF; Iijima, H; Patrzyc, HB | 1 |
Box, HC; Budzinski, EE; Dawidzik, JB; DeFedericis, HC; Evans, MS; Greene, KF; Iijima, H; Patrzyc, HB; Rajecki, MJ | 1 |
Iwai, S; Shimizu, T; Takata, K; Wood, RD | 1 |
Ito, T; Kondo, A; Nishimoto, S; Terada, S | 1 |
Charlet-Berguerand, N; Conaway, JW; Conaway, R; Egly, JM; Feuerhahn, S; Kong, SE; Ziserman, H | 1 |
Hanaoka, F; Ide, H; Iwai, S; Katafuchi, A; Matsubara, M; Terato, H | 1 |
Fujiwara, Y; Inase, A; Iwai, S; Kawasaki, Y; Yoshikawa, S | 1 |
Handa, H; Hayashida, M; Ikegami, T; Ito, S; Kuraoka, I; Kwei, JS; Nakabeppu, Y; Suzuki, K; Tanaka, K | 1 |
Dabkowska, I; Gutowski, M; Haranczyk, M; Lupica, G | 1 |
Akiyama, M; Ide, H; Kubo, K; Matsuyama, S; Yamamoto, K; Yamamoto, R | 1 |
Bebenek, K; Blanco, L; Garcia-Diaz, M; Kunkel, TA; Povirk, LF; Zhou, RZ | 1 |
Adams, T; Basu, AK; Brown, KL; Jasti, VP; Stone, MP | 1 |
Goto, M; Igarashi, H; Iwaizumi, M; Kageyama, S; Kobayashi, M; Konno, H; Shinmura, K; Sugimura, H; Tsugane, S; Tsuneyoshi, T; Yamada, H | 1 |
Brosh, RM; Camerini-Otero, RD; Mason, AC; Sommers, JA; Suhasini, AN; Voloshin, ON; Wold, MS | 1 |
Bellon, S; Cunniffe, S; Lomax, M; O'Neill, P; Shikazono, N | 1 |
Chen, ZQ; Xue, Y; Zhang, CH | 1 |
Basu, AK; Brown, KL; Stone, MP | 1 |
Altamirano, A; Basu, AK; Brown, KL; Roginskaya, M; Stone, MP; Zou, Y | 1 |
Jiang, Y; Wang, Y; Yuan, B | 1 |
Belousova, EA; Fan, Y; Kubareva, EA; Lavrik, OI; Lebedeva, NA; Maga, G; Oretskaya, TS; Romanova, EA | 1 |
Chikuma, T; Katase, T; Kobayashi, S; Kotani, E; Takagi, A; Tamura, O | 1 |
Bhatia, G; Prakash, L; Prakash, S; Yoon, JH | 1 |
Azuara-Liceaga, E; Brieba, LG; Pastor-Palacios, G | 1 |
Doublié, S; Hogg, M; Seki, M; Wallace, SS; Wood, RD | 1 |
Aller, P; Doublié, S; Duclos, S; Wallace, SS | 1 |
Couve, S; Gasparutto, D; Ishchenko, AA; Mazouzi, A; Redrejo-Rodríguez, M; Saint-Pierre, C; Saparbaev, M | 1 |
Averill, A; Doublié, S; Imamura, K; Wallace, SS | 1 |
Bohr, VA; Croteau, DL; Ghosh, AK; Janscak, P; Kulikowicz, T; Popuri, V; Ramamoorthy, M; Rossi, ML; Shevelev, I; Singh, DK | 1 |
Hashiguchi, K; Igarashi, K; Kato, S; Moriwaki, T; Yonekura, S; Zhang-Akiyama, QM | 1 |
Buckle, M; Fedorova, OS; Gasparutto, D; Ishchenko, AA; Leh, H; Prorok, P; Saint-Pierre, C; Saparbaev, M; Tudek, B | 1 |
Akopiants, K; Hromas, RA; Lee, SH; Menon, V; Mohapatra, S; Povirk, LF; Ramsden, DA; Yannone, SM | 1 |
Bohr, VA; Canugovi, C; Croteau, DL; Ferrarelli, LK; Ghosh, AK; Hsu, JK; Popuri, V; Tadokoro, T | 1 |
Maher, RL; Pederson, DS; Prasad, A; Rizvanova, O; Wallace, SS | 1 |
Chen, ZQ; Liu, XQ; Xue, Y | 1 |
Park, J; Prakash, L; Prakash, S; Roy Choudhury, J; Yoon, JH | 1 |
Bohr, VA; Canugovi, C; Croteau, DL; Ghosh, S; Mattson, MP; Wilson, DM; Yoon, JS | 1 |
Breslauer, KJ; Grollman, AP; Iden, CR; Johnson, F; Minetti, CA; Remeta, DP | 1 |
Akopiants, K; Almohaini, M; Bafail, D; Chalasani, SL; Hartman, MCT; Povirk, LF; Ramsden, DA; Yannone, SM; Zhou, T | 1 |
Barrientos, C; Bitar, M; Cabrera, G; Galanti, N; Kemmerling, U; Machado, CR; Ormeño, F; Ponce, I; Ramirez, S; Sepúlveda, S; Valenzuela, L | 1 |
Gao, YQ; Liu, M; Lu, L; Song, J; Stovicek, O; Yi, C; Yue, Z; Zhang, J; Zhu, C; Zong, S | 1 |
Li, ZS; Zhang, RB; Zhao, S | 1 |
Calkins, MJ; Dizdaroglu, M; Jaruga, P; Kirkali, G; Lloyd, RS; McCullough, AK; Owen, N; Vartanian, V | 1 |
Bose, A; Lee, CY; Lee, HT; Myong, S; Opresko, PL | 1 |
Brenerman, B; Golato, T; Li, J; McNeill, DR; Sobol, RW; Wilson, DM | 1 |
Boldinova, EO; Ignatov, A; Kulbachinskiy, A; Makarova, AV | 1 |
DAS, P; Kumari, B; Sinha, KK | 1 |
Albelazi, MS; Elder, RH; Martin, PR; Mohammed, S; Mutti, L; Parsons, JL | 1 |
Clivio, P; Coantic-Castex, S; Guillaume, D; Harakat, D; Martinez, A | 1 |
Basu, AK; Greenberg, MM; Huang, H; Naldiga, S | 1 |
Baruch-Torres, N; Brieba, LG; Iwai, S; Juárez-Quintero, V; Yamamoto, J | 1 |
Iwai, S; Mizutani, K; Shiraishi, M; Yamamoto, J | 1 |
Kumar, N; Raja, S; Van Houten, B | 1 |
Guilliam, TA; Yeeles, JT | 1 |
Anderson-Steele, BM; David, SS; Lotsof, ER; Yeo, J | 1 |
Kazempour, A; Mohammadi-Manesh, H; Mohammadtabar, F; Rajaie Khorasani, R | 1 |
Akamatsu, K; Inamura, D; Nakano, T; Nishizawa, S; Sato, Y; Takaku, Y | 1 |
11 review(s) available for thymine glycol and thymine
Article | Year |
---|---|
Biomarkers of OH radical damage in vivo.
Topics: Biomarkers; DNA; Free Radicals; Hydroxides; Hydroxyl Radical; Hydroxylation; Phenylalanine; Proteins; Thymine; Thymine Nucleotides; Tyrosine | 1991 |
The role of carcinogen DNA adduct structure in the induction of mutations.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; DNA; DNA Adducts; DNA Damage; Guanine; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Thymine | 1990 |
Production and repair of DNA damage in mammalian cells.
Topics: Animals; Carcinogens; Cell Cycle; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Humans; Thymine | 1990 |
The detection of environmental mutagens and potential carcinogens.
Topics: Aging; Animals; Biological Assay; Biotransformation; Carcinogens, Environmental; DNA; DNA Repair; Female; Free Radicals; Humans; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Neoplasms; Oxidation-Reduction; Rats; Salmonella typhimurium; Thymine; Uric Acid | 1984 |
[Oxidative DNA damage].
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenosine Triphosphate; Animals; Deoxyguanosine; DNA; DNA Damage; DNA Repair; DNA Replication; Humans; Mutation; Oxidative Stress; Reactive Oxygen Species; Thymine | 2001 |
[Repair networks for base damage and single-strand breaks].
Topics: Animals; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Single-Stranded; Guanine; Humans; Poly(ADP-ribose) Polymerases; Thymine; X-ray Repair Cross Complementing Protein 1 | 2001 |
Factors influencing the removal of thymine glycol from DNA in gamma-irradiated human cells.
Topics: Animals; Cells, Cultured; Cockayne Syndrome; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Circular; DNA, Recombinant; Dose-Response Relationship, Radiation; Electrophoresis, Capillary; Endonucleases; Fluorescent Antibody Technique, Indirect; Gamma Rays; Humans; Lymphocyte Activation; Lymphocytes; Mice; Nuclear Proteins; Plasmids; Rats; Resting Phase, Cell Cycle; Sensitivity and Specificity; Thymine; Transcription Factors; Xeroderma Pigmentosum | 2001 |
Thymine DNA glycosylase.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Pair Mismatch; Base Sequence; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytosine; Deamination; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; DNA, Neoplasm; Endodeoxyribonucleases; Evolution, Molecular; Guanine; Humans; Mice; Models, Genetic; Molecular Sequence Data; Receptors, Retinoic Acid; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity; Thymine; Transcription, Genetic; Transfection; Uracil | 2001 |
Base excision repair in nuclear and mitochondrial DNA.
Topics: Adenine; Aging; Animals; Base Sequence; Cell Line; Cell Nucleus; Cell-Free System; DNA; DNA Damage; DNA Glycosylases; DNA Polymerase beta; DNA Repair; DNA-Formamidopyrimidine Glycosylase; DNA, Mitochondrial; Guanine; Hypoxanthine; Lymphocytes; Mammals; Mice; Mitochondria; Molecular Sequence Data; N-Glycosyl Hydrolases; Oxidants; Oxidation-Reduction; Oxidative Stress; Point Mutation; Proliferating Cell Nuclear Antigen; Rats; Thymine | 2001 |
Properties and functions of human uracil-DNA glycosylase from the UNG gene.
Topics: Animals; Apurinic Acid; Bacterial Proteins; Binding Sites; Catalytic Domain; Cell Cycle; Chromosome Mapping; Chromosomes, Human, Pair 12; Deoxyribonuclease (Pyrimidine Dimer); Deoxyuracil Nucleotides; DNA Glycosylases; DNA Repair; DNA, Mitochondrial; Endodeoxyribonucleases; Escherichia coli; Gene Expression Regulation, Enzymologic; Genes; Humans; Mice; Mice, Knockout; Mitochondria; Multigene Family; N-Glycosyl Hydrolases; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pyrimidines; Thymine; Uracil-DNA Glycosidase | 2001 |
The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage.
Topics: 5-Methylcytosine; DNA Damage; DNA Repair; DNA-Binding Proteins; Guanine; Humans; Oxidation-Reduction; Oxidative Stress; Thymine; Xeroderma Pigmentosum | 2020 |
171 other study(ies) available for thymine glycol and thymine
Article | Year |
---|---|
Melanin both causes and prevents oxidative base damage in DNA: quantification by anti-thymine glycol antibody.
Topics: Antibodies; Cross Reactions; DNA; DNA Damage; Free Radicals; Melanins; Radiation Dosage; Thymine | 1992 |
Relationship of resistance to oxygen free radicals to CuZn-superoxide dismutase activity in transgenic, transfected, and trisomic cells.
Topics: Animals; Catalase; Cell Survival; Cells, Cultured; DNA; DNA Damage; Dose-Response Relationship, Drug; Free Radicals; Glutathione Peroxidase; HeLa Cells; Humans; In Vitro Techniques; Mice; Mice, Transgenic; Paraquat; Superoxide Dismutase; Thymine; Transfection; Trisomy | 1992 |
32P-postlabeling detection of radiation-induced DNA damage: identification and estimation of thymine glycols and phosphoglycolate termini.
Topics: Adenosine Triphosphate; Alkaline Phosphatase; Deoxyribonuclease I; DNA; DNA Damage; DNA Repair; Genetic Markers; Glycolates; Hydrolysis; Hydroxides; Hydroxyl Radical; Osmium Tetroxide; Phosphodiesterase I; Phosphoric Diester Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Polynucleotide 5'-Hydroxyl-Kinase; Pyrimidine Dimers; T-Phages; Thymine; X-Rays | 1991 |
Thymine glycols and pyrimidine dimers in brain DNA during post-ischemic reperfusion.
Topics: Animals; Brain Ischemia; DNA; DNA Damage; Dogs; Enzyme-Linked Immunosorbent Assay; Free Radicals; Pyrimidine Dimers; Reperfusion Injury; Thymine; Transcription, Genetic | 1991 |
32P-postlabeling detection of thymine glycols: evaluation of adduct recoveries after enhancement with affinity chromatography, nuclease P1, nuclease S1, and polynucleotide kinase.
Topics: Adenosine Triphosphate; Autoradiography; Benzene; Chromatography, Affinity; Chromatography, Thin Layer; DNA; DNA Damage; Dose-Response Relationship, Drug; In Vitro Techniques; Osmium Tetroxide; Phosphorus Radioisotopes; Polynucleotide 5'-Hydroxyl-Kinase; Single-Strand Specific DNA and RNA Endonucleases; Thymine | 1991 |
Radical-mediated DNA damage in presence of oxygen.
Topics: Alkaline Phosphatase; Deoxyribonuclease I; Deoxyribonucleosides; DNA Damage; DNA Repair; Escherichia coli; Free Radicals; Hydrolysis; Methods; Micrococcus; Oxidation-Reduction; Oxygen; Phosphoric Diester Hydrolases; Thymine | 1990 |
Ultraviolet-induced thymine hydrates in DNA are excised by bacterial and human DNA glycosylase activities.
Topics: Bacterial Proteins; Cells, Cultured; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Glycosylases; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Fibroblasts; Humans; N-Glycosyl Hydrolases; Poly dA-dT; Thymine; Ultraviolet Rays | 1990 |
No measurable increase in thymidine glycol or 8-hydroxydeoxyguanosine in liver DNA of rats treated with nafenopin or choline-devoid low-methionine diet.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Deoxyguanosine; DNA; DNA Damage; Electrochemistry; Liver; Male; Methionine; Nafenopin; Propionates; Rats; Rats, Inbred F344; Thymine | 1990 |
UvrABC nuclease complex repairs thymine glycol, an oxidative DNA base damage.
Topics: Apurinic Acid; Bacteriophages; DNA Repair; DNA, Viral; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Fluorometry; Gram-Negative Aerobic Bacteria; Hydroxylamines; Oxidation-Reduction; Substrate Specificity; Thymine; Transduction, Genetic; Transfection | 1990 |
Thymine glycol-DNA glycosylase/AP endonuclease of CEM-C1 lymphoblasts: a human analog of Escherichia coli endonuclease III.
Topics: Cations, Divalent; Cell Line; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; Lymphocytes; Molecular Weight; Osmium Tetroxide; Thymine; Ultraviolet Rays | 1987 |
Excision repair of thymine glycols, urea residues, and apurinic sites in Escherichia coli.
Topics: Coliphages; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Exodeoxyribonucleases; Mutation; SOS Response, Genetics; Substrate Specificity; Thymine; Transfection; Ultraviolet Rays; Urea | 1988 |
Immunochemical quantitation of thymine glycol in oxidized and X-irradiated DNA.
Topics: Bacteriophage phi X 174; DNA; DNA Damage; DNA, Bacterial; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Osmium Tetroxide; Oxidation-Reduction; Thymine | 1989 |
SOS processing of unique oxidative DNA damages in Escherichia coli.
Topics: Binding Sites; Coliphages; DNA Damage; DNA, Bacterial; Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Glycosides; Mutation; Oxidation-Reduction; Thymine; Transfection; Urea | 1989 |
Mutagenic specificity of alkylated and oxidized DNA bases as determined by site-specific mutagenesis.
Topics: DNA Mutational Analysis; DNA, Bacterial; Escherichia coli; Guanine; Mutation; Thymine | 1989 |
Processing of ring saturation and fragmentation products of DNA thymine in Escherichia coli.
Topics: DNA Damage; Escherichia coli; Thymine | 1989 |
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.
Topics: Base Sequence; Coliphages; DNA Replication; Escherichia coli; Genes, Viral; Models, Genetic; Models, Molecular; Mutagens; Mutation; Nucleic Acid Conformation; Thymine | 1989 |
A new mechanism for repairing oxidative damage to DNA: (A)BC excinuclease removes AP sites and thymine glycols from DNA.
Topics: DNA Damage; DNA Repair; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Kinetics; Oxidation-Reduction; Plasmids; Thymine | 1989 |
Template length, sequence context, and 3'-5' exonuclease activity modulate replicative bypass of thymine glycol lesions in vitro.
Topics: Base Sequence; DNA Damage; DNA Polymerase I; DNA Polymerase II; DNA Replication; DNA-Directed DNA Polymerase; Exodeoxyribonuclease V; Exodeoxyribonucleases; HeLa Cells; Humans; Oligodeoxyribonucleotides; Templates, Genetic; Thymine | 1989 |
Enhanced transforming activity of pSV2 plasmids in human cells depends upon the type of damage introduced into the plasmid.
Topics: Cell Line; DNA Damage; Escherichia coli; Humans; Plasmids; Pyrimidine Dimers; Simian virus 40; Thymine; Transformation, Genetic; Ultraviolet Rays | 1988 |
Oxidative damage in murine tumor cells treated in vitro by recombinant human tumor necrosis factor.
Topics: Animals; DNA Damage; Drug Resistance; Glutathione; Hydrogen Peroxide; Mice; Oxidation-Reduction; Recombinant Proteins; Thymine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1989 |
Absence of pyrimidine salvage and prevention of thymineless radiosensitization in Escherichia coli thyA cells fed dihydrothymine or thymine glycol.
Topics: Dose-Response Relationship, Radiation; Escherichia coli; Mutation; Pyrimidines; Thymine | 1988 |
DNA repair in specific sequences in mammalian cells.
Topics: Acetoxyacetylaminofluorene; Aflatoxins; Animals; Base Sequence; Cells, Cultured; Cricetinae; Cricetulus; DNA; DNA Repair; Furocoumarins; Haplorhini; Humans; Mice; Proto-Oncogene Mas; Thymine; Ultraviolet Rays | 1987 |
Oxidative damage to DNA: relation to species metabolic rate and life span.
Topics: Aging; Animals; DNA Damage; Energy Metabolism; Glycols; Haplorhini; Mice; Oxidation-Reduction; Thymidine; Thymine | 1988 |
Urine biomarkers for oxidative DNA damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Deoxyguanosine; DNA Damage; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Mice; Rats; Thymidine; Thymine | 1988 |
Relationship between the induction of mitotic gene conversion and the formation of thymine glycols in yeast S. cerevisiae treated with hydrogen peroxide.
Topics: Antibodies, Monoclonal; Dose-Response Relationship, Drug; Gene Conversion; Hydrogen Peroxide; Mitosis; Saccharomyces cerevisiae; Thymine; Tryptophan | 1988 |
Oxidative damage in DNA. Lack of mutagenicity by thymine glycol lesions.
Topics: Base Sequence; Coliphages; DNA Damage; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Mutation; Osmium Tetroxide; Thymine | 1988 |
Production of thymine glycols in DNA by radiation and chemical carcinogens as detected by a monoclonal antibody.
Topics: 2-Naphthylamine; Antibodies, Monoclonal; Benzopyrenes; Carcinogens; Cells, Cultured; DNA; DNA Damage; Fibroblasts; Humans; Thymine; Ultraviolet Rays | 1987 |
The biological consequences of oxidized DNA bases.
Topics: Bacteriophages; DNA Damage; DNA, Viral; Models, Biological; Models, Molecular; Thymine; Urea | 1987 |
Thymine glycol lesions terminate chain elongation by DNA polymerase I in vitro.
Topics: Base Sequence; Coliphages; DNA Polymerase I; DNA-Directed DNA Polymerase; DNA, Circular; DNA, Single-Stranded; Escherichia coli; T-Phages; Templates, Genetic; Thymine | 1986 |
Dithiothreitol-induced oxidative damage to thymine and DNA in solution.
Topics: Dithiothreitol; DNA Damage; DNA, Bacterial; Free Radicals; In Vitro Techniques; Oxidation-Reduction; Solutions; Thymine | 1987 |
Functional effects of cis-thymine glycol lesions on DNA synthesis in vitro.
Topics: Base Sequence; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; HeLa Cells; Humans; Oligodeoxyribonucleotides; Stereoisomerism; T-Phages; Thymine | 1987 |
Modeling and molecular mechanical studies of the cis-thymine glycol radiation damage lesion in DNA.
Topics: Base Sequence; DNA; DNA Damage; Models, Molecular; Nucleic Acid Conformation; Stereoisomerism; Thymine | 1987 |
Formation of methyl ester of 2-methylglyceric acid from thymine glycol residues: a convenient new method for determining radiation damage to DNA.
Topics: Animals; Borohydrides; Cell Line; Cricetinae; Cricetulus; DNA; Female; Glyceric Acids; Magnetic Resonance Spectroscopy; Ovary; Thymine; Tritium; X-Rays | 1986 |
Possible role for thymine glycol in the selective inhibition of DNA synthesis on oxidized DNA templates.
Topics: Coliphages; DNA; DNA Polymerase I; DNA Replication; DNA, Single-Stranded; Escherichia coli; Oxidation-Reduction; Potassium Permanganate; Templates, Genetic; Thymine; Virus Replication | 1985 |
Thymine glycols and urea residues in M13 DNA constitute replicative blocks in vitro.
Topics: Bacterial Proteins; Coliphages; DNA Replication; DNA-Directed DNA Polymerase; DNA, Single-Stranded; DNA, Viral; Escherichia coli; Osmium Tetroxide; T-Phages; Templates, Genetic; Thymine; Urea; Viral Proteins; Virus Replication | 1985 |
Production of thymine glycols in DNA by N-hydroxy-2-naphthylamine as detected by a monoclonal antibody.
Topics: 2-Naphthylamine; Antibodies, Monoclonal; Catalase; Cells, Cultured; DNA Repair; Dose-Response Relationship, Drug; Free Radicals; Glycols; Humans; Naphthalenes; Superoxide Dismutase; Thymine; Xeroderma Pigmentosum | 1986 |
Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase I.
Topics: Base Sequence; Coliphages; DNA Polymerase I; DNA, Single-Stranded; DNA, Viral; Osmium Tetroxide; Substrate Specificity; Templates, Genetic; Thymine | 1986 |
Detection and repair of DNA base damages produced by ionizing radiation.
Topics: Coliphages; Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Repair; DNA Replication; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Viral; Dose-Response Relationship, Radiation; Endodeoxyribonucleases; Genes, Viral; Immunoenzyme Techniques; Kinetics; Radiation, Ionizing; Substrate Specificity; Thymine | 1983 |
Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage.
Topics: Animals; Chromatography, High Pressure Liquid; DNA Replication; Germ-Free Life; Glucose; Humans; Rats; Species Specificity; Spectrophotometry, Ultraviolet; Thymidine; Thymine; Tritium | 1984 |
Radiation-induced hydroxylation of thymine promoted by electron-affinic compounds.
Topics: Air; Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Gamma Rays; Hydroxylation; Nitrobenzenes; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Quinones; Radiation-Sensitizing Agents; Solutions; Thymine; Water | 1983 |
Properties of antibodies to thymine glycol, a product of the radiolysis of DNA.
Topics: Animals; Antibody Formation; Antibody Specificity; DNA; Enzyme-Linked Immunosorbent Assay; Rabbits; Thymine | 1984 |
Monoclonal antibody to DNA containing thymine glycol.
Topics: Animals; Antibodies, Monoclonal; DNA; DNA, Bacterial; Enzyme-Linked Immunosorbent Assay; Hybridomas; Lymphocytes; Mice; Mice, Inbred BALB C; Plasmacytoma; Poly T; Thymine; Thymus Gland; Ultraviolet Rays | 1983 |
Identification of the cis-thymine glycol moiety in oxidized deoxyribonucleic acid.
Topics: Chemical Phenomena; Chemistry; DNA, Bacterial; Escherichia coli; Oxidation-Reduction; Potassium Permanganate; Thymidine; Thymine | 1981 |
Radioimmunoassay of a thymine glycol.
Topics: Animals; Rabbits; Radioimmunoassay; Thymine | 1982 |
Identification of the cis-thymine glycol moiety in chemically oxidized and gamma-irradiated deoxyribonucleic acid by high-pressure liquid chromatography analysis.
Topics: Chromatography, High Pressure Liquid; DNA; Gamma Rays; Oxidation-Reduction; Thymidine; Thymine | 1981 |
Determination of thymine ring saturation products of the 5,6-dihydroxydihydrothymine type by the alkali degradation assay.
Topics: Alkalies; Cobalt Radioisotopes; DNA Repair; DNA, Bacterial; Gamma Rays; Hot Temperature; Micrococcus; Thymine | 1980 |
The yeast RAD2, but not RAD1, gene is involved in the transcription-coupled repair of thymine glycols.
Topics: DNA Probes; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Endodeoxyribonucleases; Endonucleases; Enzyme-Linked Immunosorbent Assay; Fungal Proteins; Genes, Fungal; Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thymine; Time Factors; Transcription, Genetic | 1995 |
Thymine ring saturation and fragmentation products: lesion bypass, misinsertion and implications for mutagenesis.
Topics: Base Sequence; DNA Damage; DNA Polymerase I; DNA Replication; DNA, Single-Stranded; Escherichia coli; Free Radicals; Glycosides; Molecular Sequence Data; Mutagenesis; Pyrimidines; Thymine; Transfection; Urea | 1993 |
Molecular dynamics simulations of the effects of ring-saturated thymine lesions on DNA structure.
Topics: Base Sequence; Computer Simulation; DNA; DNA Damage; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Solvents; Structure-Activity Relationship; Thymine | 1995 |
Induction of base damage in DNA solutions by ultrasonic cavitation.
Topics: Adenine; Animals; Cattle; Cytosine; DNA Damage; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydrogen Peroxide; Hydroxyl Radical; Purines; Pyrimidines; Thymine; Ultrasonics | 1995 |
Purification and properties of yeast redoxyendonuclease.
Topics: Base Sequence; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chromatography, Liquid; Deoxyadenine Nucleotides; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; Endodeoxyribonucleases; Indicators and Reagents; Molecular Sequence Data; Molecular Weight; Phosphorus Radioisotopes; Radioisotope Dilution Technique; Restriction Mapping; Saccharomyces cerevisiae; Substrate Specificity; Thymine | 1994 |
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA Damage; DNA, Neoplasm; Gas Chromatography-Mass Spectrometry; Guanine; Hydrolysis; Liver; Liver Neoplasms, Experimental; Lung; Lung Neoplasms; Male; Methylamines; Nitrates; Oxidation-Reduction; Pyrimidines; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thymine; Uracil | 1995 |
Ab initio theoretical study of the structures of thymine glycol and dihydrothymine.
Topics: DNA; DNA Damage; Free Radicals; Thymine | 1993 |
DNA deoxyribophosphodiesterase and an activity that cleaves DNA containing thymine glycol adducts in Deinococcus radiodurans.
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; DNA Damage; DNA Repair; DNA, Bacterial; Electrophoresis, Agar Gel; Gram-Positive Cocci; Hydrolysis; Phosphoric Diester Hydrolases; Thymine | 1994 |
Plutonium-catalyzed oxidative DNA damage in the absence of significant alpha-particle decay.
Topics: Alpha Particles; Animals; Ascorbic Acid; Cattle; DNA; DNA Damage; Hydrogen Peroxide; Hydrogen-Ion Concentration; Iron; Kinetics; Oxidation-Reduction; Plutonium; Thymine | 1994 |
Oxidative damage to DNA: levels of thymine glycol and thymidine glycol in neoplastic human urines.
Topics: Adolescent; Adult; Aged; DNA Damage; DNA Repair; Female; Humans; Male; Middle Aged; Neoplasms; Oxidation-Reduction; Thymidine; Thymine | 1993 |
Characterization of the effects of a thymine glycol residue on the structure, dynamics, and stability of duplex DNA by NMR.
Topics: Base Sequence; Chromatography, High Pressure Liquid; DNA; Drug Stability; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oxidation-Reduction; Thymine | 1993 |
Zinc deficiency in antibody-conjugated alkaline phosphatase inhibits enzyme activity in ELISAs.
Topics: Alkaline Phosphatase; Animals; Biotechnology; Buffers; DNA Damage; Enzyme-Linked Immunosorbent Assay; Glycine; Thymine; Zinc | 1993 |
Oxidative damage in double-stranded genomic DNA as measured by GC/MS assay of a thymine glycol derivative.
Topics: Animals; Base Composition; Base Sequence; Biomarkers; Cells, Cultured; DNA; DNA Damage; Free Radicals; Gas Chromatography-Mass Spectrometry; Genes; Oxidation-Reduction; Thymine | 1993 |
Purification of a mammalian homologue of Escherichia coli endonuclease III: identification of a bovine pyrimidine hydrate-thymine glycol DNAse/AP lyase by irreversible cross linking to a thymine glycol-containing oligoxynucleotide.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cattle; Cross-Linking Reagents; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA Glycosylases; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; In Vitro Techniques; Lyases; Molecular Sequence Data; Molecular Weight; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Oxidation-Reduction; Rats; Sequence Homology, Amino Acid; Substrate Specificity; Thymine | 1996 |
Damage and repair of DNA after liver transplantation assessed by urinary thymine glycol output.
Topics: Animals; Biomarkers; DNA Damage; DNA Repair; Liver; Liver Transplantation; Male; Organ Preservation; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Thymine; Time Factors; Transplantation, Homologous; Transplantation, Isogeneic | 1996 |
DNA strand breakage, thymine glycol production, and hydroxyl radical generation induced by different samples of crystalline silica in vitro.
Topics: Animals; Crystallization; DNA Damage; Electron Spin Resonance Spectroscopy; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyl Radical; Oxygen; Silicon Dioxide; Thymine | 1995 |
Molecular cloning and functional analysis of a Schizosaccharomyces pombe homologue of Escherichia coli endonuclease III.
Topics: Amino Acid Sequence; Cloning, Molecular; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli Proteins; Eukaryotic Cells; Lyases; Molecular Sequence Data; N-Glycosyl Hydrolases; Recombinant Proteins; Schizosaccharomyces; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Thymine; Urea | 1996 |
Structure of a duplex DNA containing a thymine glycol residue in solution.
Topics: Chromatography, High Pressure Liquid; DNA; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Surface Properties; Thymine | 1997 |
Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.
Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Cell Survival; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Neoplasm; Humans; Metallothionein; Mutation; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Proto-Oncogene Proteins; Thymine; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Use of a postlabelling assay to examine the removal of radiation-induced DNA lesions by purified enzymes and human cell extracts.
Topics: Cell Extracts; Cell Survival; Deoxyribonuclease I; Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Single-Stranded; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Gamma Rays; Glycolates; Humans; Lyases; Magnesium; Nucleic Acid Denaturation; Phosphorus Radioisotopes; Thymine; Tumor Cells, Cultured | 1997 |
Transfection enhancement in Bacillus subtilis displays features of a novel DNA repair pathway. I: DNA base and nucleolytic specificity.
Topics: Bacillus subtilis; Bacteriophages; Base Composition; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli Proteins; N-Glycosyl Hydrolases; Pentoxyl; Pyrimidines; Substrate Specificity; Thymine; Transfection; Ultraviolet Rays; Uracil-DNA Glycosidase | 1997 |
Purification of thymine glycol DNA and nucleosides by use of boronate chromatography.
Topics: Boron Compounds; Chromatography, High Pressure Liquid; DNA; DNA Damage; Thymidine; Thymine | 1998 |
Determination of cis-thymine glycol in DNA by gas chromatography-mass spectrometry with selected ion recording and multiple reaction monitoring.
Topics: Acetamides; Animals; Antioxidants; Calibration; Cattle; DNA; Female; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Organosilicon Compounds; Osmolar Concentration; Placenta; Pregnancy; Reference Standards; Stereoisomerism; Thymine; Thymus Gland; Trifluoroacetic Acid; Tritium | 1997 |
Enzymatic processing of uracil glycol, a major oxidative product of DNA cytosine.
Topics: Adenosine Triphosphate; Base Composition; Base Sequence; Cytosine; Deoxyadenine Nucleotides; DNA; DNA Damage; DNA Polymerase I; DNA Primers; DNA Repair; Escherichia coli; Kinetics; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oxidation-Reduction; Templates, Genetic; Thymine; Uracil | 1998 |
Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage.
Topics: Antibodies, Monoclonal; Bromodeoxyuridine; DNA Damage; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Radiation; Electrophoresis, Capillary; Humans; Radiation, Ionizing; Thymine; Tumor Cells, Cultured | 1998 |
Zeptomolar damage.
Topics: Antibodies, Monoclonal; DNA Damage; DNA Repair; DNA, Neoplasm; Electrophoresis, Capillary; Fluorescent Dyes; Humans; Radiation, Ionizing; Sensitivity and Specificity; Thymine; Tumor Cells, Cultured | 1998 |
Replication inhibition and miscoding properties of DNA templates containing a site-specific cis-thymine glycol or urea residue.
Topics: DNA; DNA Damage; DNA Replication; Humans; Thymine; Urea | 1998 |
Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae.
Topics: DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Fungal; Fungal Proteins; Genes, Fungal; Genome, Fungal; Pyrimidine Dimers; Saccharomyces cerevisiae; Thymine; Transcription, Genetic | 1998 |
Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies.
Topics: Adenine; Aged; Aged, 80 and over; Alzheimer Disease; Brain Chemistry; Cerebral Cortex; Cytosine; DNA; Guanine; Humans; Hydantoins; Hypoxanthine; Lewy Bodies; Lipid Peroxidation; Middle Aged; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Thymine; Uracil; Xanthine | 1998 |
BRCA1 required for transcription-coupled repair of oxidative DNA damage.
Topics: Alleles; Animals; BRCA1 Protein; Cell Line; DNA Damage; DNA Repair; Hydrogen Peroxide; Mice; Oxidation-Reduction; Stem Cells; Thymine; Transcription, Genetic; Ultraviolet Rays | 1998 |
Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III.
Topics: Amino Acid Sequence; Animals; Blotting, Southern; Carbon-Oxygen Lyases; Cloning, Molecular; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA Glycosylases; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Exons; Expressed Sequence Tags; Humans; Introns; Mice; Mice, Inbred BALB C; Molecular Sequence Data; N-Glycosyl Hydrolases; Open Reading Frames; Physical Chromosome Mapping; Recombinant Fusion Proteins; Repressor Proteins; Response Elements; RNA, Messenger; Sequence Homology, Amino Acid; Thymine; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Urea | 1998 |
Excision of products of oxidative DNA base damage by human NTH1 protein.
Topics: Barbiturates; Cytosine; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; Kinetics; Oxidation-Reduction; Substrate Specificity; Thymine; Uracil | 1999 |
Excision of 5,6-dihydroxy-5,6-dihydrothymine, 5,6-dihydrothymine, and 5-hydroxycytosine from defined sequence oligonucleotides by Escherichia coli endonuclease III and Fpg proteins: kinetic and mechanistic aspects.
Topics: Cytosine; Deoxyribonuclease (Pyrimidine Dimer); DNA Repair; DNA-Formamidopyrimidine Glycosylase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Gas Chromatography-Mass Spectrometry; Kinetics; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Thymine | 1999 |
The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast.
Topics: Amino Acid Sequence; Cytosine; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Fungal; Gene Targeting; Genes, Fungal; Helix-Loop-Helix Motifs; Hydrogen Peroxide; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; N-Glycosyl Hydrolases; Oxidative Stress; Pyrimidines; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Substrate Specificity; Thymine; Ultraviolet Rays | 1999 |
Transcription dependence and the roles of two excision repair pathways for UV damage in fission yeast Schizosaccharomyces pombe.
Topics: Cell Cycle Proteins; Cloning, Molecular; DNA Damage; DNA Repair; DNA, Fungal; Fungal Proteins; Molecular Sequence Data; Open Reading Frames; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Thymine; Transcription, Genetic; Ultraviolet Rays | 1999 |
Dietary supplement of G-rutin reduces oxidative damage in the rodent model.
Topics: Animals; Antioxidants; Body Weight; Dietary Supplements; DNA Damage; Energy Intake; Lipid Peroxidation; Liver; Male; Proteins; Rats; Rats, Sprague-Dawley; Rutin; Thymine; Trisaccharides; Vitamins | 1999 |
Double-base lesions are produced in DNA by free radicals.
Topics: Adenosine Triphosphate; Animals; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Damage; Dose-Response Relationship, Radiation; Formamides; Free Radicals; Guanine; Pyrimidine Nucleosides; Single-Strand Specific DNA and RNA Endonucleases; Spectrometry, Mass, Fast Atom Bombardment; Thymine; Thymus Gland; X-Rays | 2000 |
Single nucleotide patch base excision repair is the major pathway for removal of thymine glycol from DNA in human cell extracts.
Topics: Base Sequence; Cell Line; DNA; DNA Repair; Fibroblasts; Humans; Molecular Sequence Data; Mutagenesis; Restriction Mapping; Thymine; Xeroderma Pigmentosum | 2000 |
Purification and characterization of a novel DNA repair enzyme from the extremely radioresistant bacterium Rubrobacter radiotolerans.
Topics: Apurinic Acid; Arthrobacter; Bacterial Proteins; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Ligases; DNA Repair; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Endodeoxyribonucleases; Endonucleases; Escherichia coli; Escherichia coli Proteins; Radiation Tolerance; Radon; Substrate Specificity; Thymine; Urea; Water Microbiology | 2000 |
Comparison of substrate specificities of Escherichia coli endonuclease III and its mouse homologue (mNTH1) using defined oligonucleotide substrates.
Topics: Animals; Base Pairing; Borohydrides; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; Endodeoxyribonucleases; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Mice; Oligonucleotides; Oligopeptides; Schiff Bases; Sequence Homology, Amino Acid; Stereoisomerism; Substrate Specificity; Thymine; Uracil; Urea | 2000 |
Measuring DNA damage using capillary electrophoresis with laser-induced fluorescence detection.
Topics: Animals; Bromodeoxyuridine; DNA Damage; Electrophoresis, Capillary; Fluorescent Dyes; Humans; Immunoassay; Immunoglobulin G; Lasers; Mice; Microscopy, Fluorescence; Radiation, Ionizing; Thymine; Time Factors | 2000 |
Repair of clustered DNA damage caused by high LET radiation in human fibroblasts.
Topics: Cells, Cultured; DNA; DNA Damage; DNA Fragmentation; DNA Repair; DNA, Single-Stranded; Dose-Response Relationship, Radiation; Fibroblasts; Heavy Ions; Humans; Linear Energy Transfer; Nucleic Acid Hybridization; Particle Accelerators; Radiobiology; Skin; Thymine; X-Rays | 1998 |
Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II.
Topics: Animals; Base Sequence; Chromatography, High Pressure Liquid; DNA; DNA-Directed RNA Polymerases; DNA, Circular; Liver; Oligonucleotides; Oxidative Stress; Phosphorylation; Rats; RNA; RNA Polymerase II; Thymine; Time Factors; Transcription, Genetic; Viral Proteins | 2001 |
Evaluation of phosphodiesterase I-based protocols for the detection of multiply damaged sites in DNA: the detection of abasic, oxidative and alkylative tandem damage in DNA oligonucleotides.
Topics: Alkylation; Chromatography, High Pressure Liquid; DNA Damage; Furans; Oligodeoxyribonucleotides; Organophosphates; Oxidation-Reduction; Phosphodiesterase I; Phosphoric Diester Hydrolases; Spectrometry, Mass, Electrospray Ionization; Thymine | 2001 |
Synthesis and thermodynamic studies of oligonucleotides containing the two isomers of thymine glycol.
Topics: Amides; DNA Damage; Drug Stability; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Oligonucleotides; Phosphoric Acids; Stereoisomerism; Temperature; Thermodynamics; Thymine | 2001 |
Determination of active site residues in Escherichia coli endonuclease VIII.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Deoxyribonuclease (Pyrimidine Dimer); DNA Primers; Dose-Response Relationship, Drug; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Kinetics; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxygen; Plasmids; Proline; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Thymine; Uracil | 2002 |
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells.
Topics: Adenosine Triphosphatases; Amino Acid Motifs; Amino Acid Sequence; Apoptosis; Cell Extracts; Cell Line; Cell Survival; Cockayne Syndrome; Cytosine; DNA Damage; DNA Helicases; DNA Repair; DNA Repair Enzymes; Fibroblasts; Gene Expression Profiling; Genetic Complementation Test; Guanine; Humans; Hydrogen Peroxide; Mutation; Oligonucleotide Array Sequence Analysis; Poly-ADP-Ribose Binding Proteins; Protein Structure, Tertiary; Radiation Tolerance; RNA; Thymine; Ultraviolet Rays | 2002 |
Translesion synthesis by human DNA polymerase eta across thymine glycol lesions.
Topics: Base Sequence; DNA; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Humans; In Vitro Techniques; Kinetics; Pyrimidine Dimers; Recombinant Proteins; Substrate Specificity; Thymine | 2002 |
HPLC isolation and mass spectrometric characterization of two isomers of thymine glycols in oligodeoxynucleotides.
Topics: Chromatography, High Pressure Liquid; Nucleotides; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Thymine | 2002 |
Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols.
Topics: Alleles; Animals; Cell Nucleus; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Repair; DNA, Mitochondrial; Endodeoxyribonucleases; Escherichia coli Proteins; Female; Gene Targeting; Liver; Male; Mice; Mice, Knockout; Mitochondria, Liver; Mitochondrial Proteins; Oxidative Stress; Phenotype; Thymine | 2002 |
Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decay.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alpha Particles; Animals; Ascorbic Acid; Catalase; Cattle; Deoxyguanosine; DNA; DNA Damage; Free Radical Scavengers; Humans; Hydrogen Peroxide; Iron; Nickel; Oxidants; Oxidation-Reduction; Radiation Injuries; Superoxide Dismutase; Thymine; Uranium | 2002 |
Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides.
Topics: Adenine; Base Sequence; DNA; DNA Damage; DNA Primers; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Humans; Nucleic Acid Conformation; Proteins; Substrate Specificity; Templates, Genetic; Thymine | 2002 |
Global genome removal of thymine glycol in Escherichia coli requires endonuclease III but the persistence of processed repair intermediates rather than thymine glycol correlates with cellular sensitivity to high doses of hydrogen peroxide.
Topics: Cell Death; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Genome, Bacterial; Hydrogen Peroxide; Kinetics; Temperature; Thymine | 2002 |
Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol.
Topics: Base Pairing; DNA Damage; DNA Polymerase III; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; DNA, Fungal; Free Radicals; Fungal Proteins; Kinetics; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thymine | 2003 |
Mode of inhibition of short-patch base excision repair by thymine glycol within clustered DNA lesions.
Topics: Carbon-Oxygen Lyases; Chromatography, High Pressure Liquid; DNA; DNA Damage; DNA Polymerase beta; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Dose-Response Relationship, Drug; HeLa Cells; Humans; Oligonucleotides; Osmium Tetroxide; Ribosemonophosphates; Thymine; Time Factors | 2003 |
Endonuclease IV enhances base excision repair of endonuclease III from Methanobacterium thermoautotrophicum.
Topics: Amino Acid Sequence; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Guanine; Methanobacterium; Molecular Sequence Data; Oligonucleotides; Oxygen; Protein Binding; Recombinant Proteins; Sequence Homology, Amino Acid; Sodium Chloride; Thymine | 2003 |
Oxidative DNA damage following exposure to dimethylarsinous iodide: the formation of cis-thymine glycol.
Topics: Cacodylic Acid; Catalase; DNA Damage; Gas Chromatography-Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Superoxide Dismutase; Thymine | 2003 |
Synthesis of a thymine glycol building block and its incorporation into oligonucleotides.
Topics: Base Sequence; Chromatography, High Pressure Liquid; DNA Damage; Methods; Molecular Structure; Oligodeoxyribonucleotides; Osmium Tetroxide; Oxidation-Reduction; Thymine | 2000 |
Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.
Topics: 5-Methylcytosine; Base Pair Mismatch; Deamination; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Guanine; Humans; Models, Genetic; Mutation; Oligonucleotides; Recombinant Proteins; Substrate Specificity; Thymine; Thymine DNA Glycosylase | 2003 |
Stereoselective excision of thymine glycol from oxidatively damaged DNA.
Topics: Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Escherichia coli Proteins; Kinetics; N-Glycosyl Hydrolases; Oligonucleotides; Oxidation-Reduction; Oxidative Stress; Saccharomyces cerevisiae Proteins; Stereoisomerism; Substrate Specificity; Thymine | 2004 |
Single-stranded breaks in DNA but not oxidative DNA base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts.
Topics: Cell Extracts; Cell Nucleus; Cytosine; Deoxyribonucleosides; DNA Damage; DNA Repair; Guanine; HeLa Cells; Humans; Oxidation-Reduction; Pyrimidine Dimers; RNA Polymerase II; Templates, Genetic; Thymine; Transcription, Genetic | 2004 |
Stereoselective excision of thymine glycol lesions by mammalian cell extracts.
Topics: Animals; Cell Extracts; Cell Nucleus; Cross-Linking Reagents; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; Electrophoresis, Polyacrylamide Gel; Kinetics; Mice; Oligonucleotides; Schiff Bases; Stereoisomerism; Thymine; Tumor Cells, Cultured | 2004 |
The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicity and tumorigenesis.
Topics: Animals; Cacodylic Acid; Carcinogens; Herbicides; Mice; Mice, Inbred ICR; Mutagens; Oxidative Stress; Thymine | 2004 |
Independent generation of the 5-hydroxy-5,6-dihydrothymidin-6-yl radical and its reactivity in dinucleoside monophosphates.
Topics: Dinucleoside Phosphates; DNA; Free Radicals; Oxygen; Photochemistry; Stereoisomerism; Thymidine; Thymine | 2004 |
High-efficiency bypass of DNA damage by human DNA polymerase Q.
Topics: Amino Acid Motifs; Amino Acid Sequence; Conserved Sequence; DNA Damage; DNA Polymerase theta; DNA-Directed DNA Polymerase; Humans; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Pyrimidine Dimers; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Templates, Genetic; Thymine | 2004 |
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.
Topics: Cloning, Molecular; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; DNA, Complementary; Escherichia coli; Humans; Hydrogen Peroxide; Mutation; Oligonucleotides; Pentoxyl; Thymine; Uracil | 2005 |
Base excision repair by hNTH1 and hOGG1: a two edged sword in the processing of DNA damage in gamma-irradiated human cells.
Topics: B-Lymphocytes; Cells, Cultured; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Glycosylases; DNA Repair; Down-Regulation; Gamma Rays; Gene Silencing; Humans; Hydrogen Peroxide; Thymine | 2006 |
Host cell reactivation of plasmids containing oxidative DNA lesions is defective in Cockayne syndrome but normal in UV-sensitive syndrome fibroblasts.
Topics: beta-Galactosidase; Cell Survival; Cells, Cultured; Cockayne Syndrome; DNA Damage; DNA Repair; DNA, Single-Stranded; Fibroblasts; Humans; Hydrogen Peroxide; Oxidative Stress; Plasmids; Syndrome; Thymine; Transfection; Ultraviolet Rays | 2006 |
Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA.
Topics: Anti-Bacterial Agents; Binding Sites; Circular Dichroism; Distamycins; DNA; DNA Damage; Hydroxylation; Imidazoles; Isomerism; Oligodeoxyribonucleotides; Solvents; Surface Plasmon Resonance; Thymidine; Thymine | 2006 |
Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization.
Topics: Base Pairing; Catalysis; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribose; DNA Damage; DNA Glycosylases; DNA Repair; Escherichia coli Proteins; Humans; Isomerism; Kinetics; Oligonucleotides; Purines; Substrate Specificity; Thymine | 2006 |
A novel approach to DNA damage assessments: measurement of the thymine glycol lesion.
Topics: Animals; Chromatography, Liquid; Dinucleoside Phosphates; DNA; DNA Damage; Dose-Response Relationship, Radiation; Fibroblasts; Mass Spectrometry; Mice; Mice, Inbred C3H; Mutagenicity Tests; Radiation Dosage; Thymine | 2006 |
Singlet oxygen-induced DNA damage.
Topics: Animals; Chromatography, Liquid; Dinucleoside Phosphates; DNA; DNA Damage; Dose-Response Relationship, Radiation; HeLa Cells; Humans; Mass Spectrometry; Mutagenicity Tests; Radiation Dosage; Singlet Oxygen; Thymine | 2006 |
Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.
Topics: Amino Acid Sequence; DNA Damage; DNA Polymerase I; DNA Polymerase theta; DNA Replication; DNA-Directed DNA Polymerase; Humans; Molecular Sequence Data; Protein Processing, Post-Translational; Recombinant Proteins; Templates, Genetic; Thymine | 2006 |
Photoinduced reductive repair of thymine glycol: implications for excess electron transfer through DNA containing modified bases.
Topics: DNA; DNA Damage; Electron Transport; Flavin-Adenine Dinucleotide; Lasers; Light; Oligonucleotides; Oxidation-Reduction; Phenothiazines; Photolysis; Thymine | 2006 |
RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors.
Topics: DNA Damage; DNA Helicases; DNA Repair; DNA Repair Enzymes; Elongin; Guanine; HeLa Cells; Humans; Oxidative Stress; Poly-ADP-Ribose Binding Proteins; RNA Polymerase II; Thymine; Transcription Factors; Transcription Factors, TFII; Transcription, Genetic; Transcriptional Elongation Factors; Uracil | 2006 |
Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions.
Topics: DNA Damage; DNA Glycosylases; HeLa Cells; Humans; Oxidation-Reduction; Pyrimidines; Solutions; Stereoisomerism; Substrate Specificity; Thymine | 2004 |
Characterization of the binding of distamycin A to damaged DNA: a comparison with the DNA recognition of the human DDB protein.
Topics: Binding Sites; Distamycins; DNA; DNA Damage; DNA-Binding Proteins; Fluorescence Resonance Energy Transfer; Humans; Nucleic Acid Conformation; Protein Binding; Pyrimidine Dimers; Surface Plasmon Resonance; Thymine | 2006 |
RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.
Topics: Adenine; Base Sequence; DNA Damage; DNA Repair; Guanine; HeLa Cells; Humans; Models, Chemical; Models, Genetic; Molecular Sequence Data; Oxygen; RNA Polymerase II; Thymine; Transcription, Genetic; Transcriptional Elongation Factors | 2007 |
Cylindrical projection of electrostatic potential and image analysis tools for damaged DNA: the substitution of thymine with thymine glycol.
Topics: Diagnostic Imaging; DNA Damage; Models, Molecular; Nucleic Acid Conformation; Oligonucleotides; Quantum Theory; Static Electricity; Thymine | 2008 |
A novel monofunctional DNA glycosylase activity against thymine glycol in mouse cell nuclei.
Topics: Animals; Blotting, Western; Cell Nucleus; Chromatography; DNA Glycosylases; DNA Repair; Fluorometry; Mice; Mice, Inbred DBA; Reverse Transcriptase Polymerase Chain Reaction; Thymine | 2008 |
Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts.
Topics: Base Pair Mismatch; Cell Extracts; Cell Nucleus; DNA Breaks, Double-Stranded; DNA Polymerase beta; DNA Repair; Guanine; HeLa Cells; Humans; Recombinant Fusion Proteins; Thymine | 2008 |
Interconversion of the cis-5R,6S- and trans-5R,6R-thymine glycol lesions in duplex DNA.
Topics: Carbohydrate Conformation; Deoxyribose; DNA; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Oligonucleotides; Thermodynamics; Thymine | 2008 |
Altered expression of the human base excision repair gene NTH1 in gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Case-Control Studies; Deoxyribonuclease (Pyrimidine Dimer); DNA, Neoplasm; Down-Regulation; Female; Gastric Mucosa; Genotype; Humans; Immunoenzyme Techniques; Intestinal Neoplasms; Luciferases; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Thymine; Young Adult | 2009 |
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.
Topics: Basic-Leucine Zipper Transcription Factors; Breast Neoplasms; DNA; DNA Adducts; DNA Damage; DNA Helicases; Enzyme Activation; Fanconi Anemia; Fanconi Anemia Complementation Group Proteins; Female; Guanine; Humans; Oxidative Stress; Replication Protein A; Substrate Specificity; Thymine | 2009 |
Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Deoxyguanosine; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Damage; DNA Repair; Escherichia coli; Mutagenesis; Thymine; Transformation, Bacterial; Uracil | 2009 |
Theoretical studies on the thermodynamics and kinetics of the N-glycosidic bond cleavage in deoxythymidine glycol.
Topics: Crystallography, X-Ray; Glycosides; Hydrolysis; Kinetics; Models, Molecular; Molecular Conformation; Solvents; Thermodynamics; Thymine; Water | 2009 |
The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with deoxyguanosine in DNA.
Topics: 5-Methylcytosine; Base Pairing; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Oligodeoxyribonucleotides; Protons; Thymine | 2009 |
Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site.
Topics: Base Pairing; Base Sequence; Binding Sites; DNA; DNA Damage; DNA Repair Enzymes; DNA-Binding Proteins; Endodeoxyribonucleases; Escherichia coli Proteins; Humans; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protons; Stereoisomerism; Thymine; Xeroderma Pigmentosum Group A Protein | 2010 |
Efficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cattle; Copper; Deoxyguanosine; DNA; DNA Damage; DNA Polymerase beta; Escherichia coli; Gamma Rays; Hydrogen Peroxide; Mutation; Thymine | 2010 |
DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures.
Topics: Base Pairing; Catalysis; DNA Damage; DNA Polymerase beta; DNA Repair; DNA Replication; Humans; Multigene Family; Proliferating Cell Nuclear Antigen; Replication Protein A; Substrate Specificity; Templates, Genetic; Thymine | 2010 |
Products of thymine oxygenation by a non-heme oxygenation model, Fe(II)(MeCN)6(2+)-Ac2O-H2O2, and the transition state model between oxoiron and thymine.
Topics: DNA Damage; Iron Compounds; Models, Biological; Oxidation-Reduction; Thymine | 2010 |
Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases kappa and zeta in human cells.
Topics: DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Humans; Thymine | 2010 |
A nuclear family A DNA polymerase from Entamoeba histolytica bypasses thymine glycol.
Topics: Cell Nucleus; DNA Polymerase III; Entamoeba histolytica; Models, Molecular; Phylogeny; Protein Structure, Tertiary; Protozoan Proteins; Recombinant Proteins; Sequence Homology; Thymine | 2010 |
Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA Damage; DNA Polymerase theta; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Genes, pol; Humans; Mice; Molecular Sequence Data; Protein Structure, Tertiary; Thymine | 2011 |
A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex.
Topics: DNA Replication; DNA-Directed DNA Polymerase; Molecular Sequence Data; Protein Binding; Protein Structure, Secondary; Thymine; Viral Proteins | 2011 |
New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.
Topics: Base Sequence; DNA; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; HeLa Cells; Humans; Hydantoins; Kinetics; Oligodeoxyribonucleotides; Oxidation-Reduction; Pyrimidines; Thymine; Urea | 2011 |
Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA.
Topics: Catalytic Domain; Crystallography, X-Ray; DNA; DNA Glycosylases; Humans; Mimiviridae; Oxidation-Reduction; Thymine; Uracil | 2012 |
The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability.
Topics: Cell Line; DNA; DNA Damage; Genomic Instability; Guanine; HeLa Cells; Humans; Protein Interaction Domains and Motifs; RecQ Helicases; S Phase; Sister Chromatid Exchange; Thymine | 2012 |
Structural and functional properties of CiNTH, an endonuclease III homologue of the ascidian Ciona intestinalis: critical role of N-terminal region.
Topics: Amino Acid Sequence; Animals; Ciona intestinalis; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Glycosylases; DNA Repair; Escherichia coli; Gene Expression Regulation; Guanine; Humans; Hydrogen Peroxide; Molecular Sequence Data; Reactive Oxygen Species; Sequence Alignment; Thymine; Uracil | 2012 |
Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.
Topics: Adenine; Biocatalysis; Cell Extracts; Cell-Free System; Cytosine; DNA Adducts; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; HeLa Cells; Humans; Kinetics; Mutagens; Oligonucleotides; Oxidation-Reduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Thymine; Time Factors | 2012 |
Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases.
Topics: DNA Adducts; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Ligases; DNA Repair Enzymes; DNA-Activated Protein Kinase; DNA-Binding Proteins; Endonucleases; Glycolates; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Nuclear Proteins; Recombinational DNA Repair; Thymine | 2013 |
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions.
Topics: DNA; DNA Adducts; DNA Damage; DNA Repair; Exodeoxyribonucleases; Humans; Nucleic Acid Conformation; Oxidation-Reduction; Reactive Oxygen Species; RecQ Helicases; Rothmund-Thomson Syndrome; Telomere; Telomeric Repeat Binding Protein 2; Thymine; Werner Syndrome Helicase | 2013 |
Contribution of DNA unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes.
Topics: Chromatin Assembly and Disassembly; DNA Damage; DNA Glycosylases; DNA Repair; DNA, Ribosomal; Histones; Humans; Kinetics; Nucleosomes; Oxidative Stress; Thymine | 2013 |
Stimulation of N--glycoside transfer in deoxythymidine glycol: mechanism of the initial step in base excision repair.
Topics: Computer Simulation; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Repair; Glycosides; Models, Chemical; Models, Molecular; Molecular Structure; Thymidine; Thymine | 2014 |
A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.
Topics: Cell Line; DNA Polymerase theta; DNA Replication; DNA-Directed DNA Polymerase; Fibroblasts; Humans; Oxidation-Reduction; Protein Structure, Tertiary; Thymine | 2014 |
Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice.
Topics: Animals; Disease Models, Animal; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Endonucleases; Gene Expression; Humans; Hypoxia, Brain; Loss of Heterozygosity; Male; Mice; Nucleotides; Risk Factors; Stroke; Thymine; X-ray Repair Cross Complementing Protein 1 | 2015 |
Impact of thymine glycol damage on DNA duplex energetics: Correlations with lesion-induced biochemical and structural consequences.
Topics: Calorimetry, Differential Scanning; Circular Dichroism; DNA; DNA Damage; Nucleic Acid Conformation; Thermodynamics; Thymine | 2015 |
Nonhomologous end joining of complex DNA double-strand breaks with proximal thymine glycol and interplay with base excision repair.
Topics: DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Repair; HCT116 Cells; Humans; Thymine | 2016 |
Expression and the Peculiar Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA Glycosylase.
Topics: Amino Acid Sequence; Animals; Cell Line; Chagas Disease; DNA Damage; DNA Glycosylases; DNA Repair; Gene Expression Regulation; Humans; Models, Molecular; Oxidative Stress; Protein Conformation; Rats; Sequence Alignment; Thymine; Trypanosoma cruzi | 2016 |
Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair.
Topics: Computer Simulation; Crystallography; DNA; DNA Glycosylases; DNA Repair; Escherichia coli; Furans; Humans; Models, Chemical; Thymine | 2016 |
A new understanding towards the reactivity of DNA peroxy radicals.
Topics: DNA; Free Radicals; Gases; Oxidation-Reduction; Thermodynamics; Thymine; Water | 2016 |
Enhanced sensitivity of Neil1
Topics: Animals; Cytokines; DNA Damage; DNA Glycosylases; DNA Repair; Gene Expression Profiling; Gene Expression Regulation; Guanine; Inflammation; Mice; Mice, Knockout; Neutrophil Infiltration; Oxidative Stress; Pyrimidines; Reactive Oxygen Species; Skin; Thymine; Ultraviolet Rays; Uracil | 2016 |
Molecular mechanisms by which oxidative DNA damage promotes telomerase activity.
Topics: Base Sequence; DNA; DNA Damage; DNA, Single-Stranded; G-Quadruplexes; Guanine; HEK293 Cells; Humans; Oxidative Stress; Protein Binding; Shelterin Complex; Telomerase; Telomere; Telomere Homeostasis; Telomere-Binding Proteins; Thymine | 2017 |
Development of a Cell-Based Assay for Measuring Base Excision Repair Responses.
Topics: Base Sequence; Biological Assay; DNA; DNA Repair; HEK293 Cells; HeLa Cells; Humans; Nucleic Acid Conformation; Oligonucleotides; Thymine; Time Factors | 2017 |
The active site residues Gln55 and Arg73 play a key role in DNA damage bypass by S. cerevisiae Pol η.
Topics: Arginine; Catalytic Domain; DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Glycine; Guanine; Mutagenesis, Site-Directed; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thymine | 2018 |
Complex interplay of lesion-specific DNA repair enzyme on bistranded clustered DNA damage harboring Tg:G mismatch in nucleosome core particles.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Cell Extracts; Deoxyguanosine; Deoxyribonuclease (Pyrimidine Dimer); DNA Breaks, Double-Stranded; DNA Damage; DNA Glycosylases; DNA Mismatch Repair; DNA Repair; HeLa Cells; Humans; Nucleosomes; Oxidative Stress; Radiation, Ionizing; Thymine | 2018 |
The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks.
Topics: Cell Cycle; DNA; DNA Glycosylases; DNA Replication; DNA, Single-Stranded; Humans; Models, Genetic; N-Glycosyl Hydrolases; Thymine; Uracil | 2019 |
The remarkable UV light invulnerability of thymine GNA dinucleotides.
Topics: Nucleic Acid Conformation; Nucleotides; Thymine; Ultraviolet Rays | 2019 |
Mutagenic Effects of a 2-Deoxyribonolactone-Thymine Glycol Tandem DNA Lesion in Human Cells.
Topics: DNA; DNA Damage; DNA Polymerase iota; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; HEK293 Cells; Humans; Mutagenesis; Mutagens; Nucleotides; Sugar Acids; Thymine | 2020 |
Plant organellar DNA polymerases bypass thymine glycol using two conserved lysine residues.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Conserved Sequence; DNA-Directed DNA Polymerase; Lysine; Organelles; Thymine | 2020 |
Mutational analysis of Thermococcus kodakarensis Endonuclease III reveals the roles of evolutionarily conserved residues.
Topics: Amino Acid Sequence; Archaeal Proteins; DNA Damage; DNA Glycosylases; DNA Repair; DNA, Archaeal; Evolution, Molecular; Kinetics; Protein Structural Elements; Sequence Analysis, Protein; Substrate Specificity; Thermococcus; Thymine | 2020 |
The eukaryotic replisome tolerates leading-strand base damage by replicase switching.
Topics: DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thymine | 2021 |
RNA Editing of the Human DNA Glycosylase NEIL1 Alters Its Removal of 5-Hydroxyuracil Lesions in DNA.
Topics: DNA; DNA Glycosylases; DNA Repair; DNA, Single-Stranded; Humans; Oxidation-Reduction; RNA Editing; Thymine; Uracil | 2021 |
Study of optical absorption cross-section spectra and high-order harmonic generation of thymine, thymine glycol, and thymine dimer molecules.
Topics: Density Functional Theory; Electrons; Pyrimidine Dimers; Thymine | 2022 |
Synthetic DNA binders for fluorescent sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity.
Topics: DNA; DNA Repair; Endonucleases; Thymine | 2023 |