Page last updated: 2024-08-22

thymine glycol and thymine

thymine glycol has been researched along with thymine in 182 studies

Research

Studies (182)

TimeframeStudies, this research(%)All Research%
pre-199038 (20.88)18.7374
1990's49 (26.92)18.2507
2000's56 (30.77)29.6817
2010's31 (17.03)24.3611
2020's8 (4.40)2.80

Authors

AuthorsStudies
Hill, GJ; Hill, HZ; Hubbard-Smith, K1
Bergtold, DS; Karam, LR; Simic, MG1
Carlson, EJ; Epstein, CJ; Huang, TT; Leadon, SA1
Soderlind, KJ; Weinfeld, M1
Krause, GS; O'Neil, BJ; White, BC1
Blackburn, GR; Bleicher, WT; Reddy, MV1
Basu, AK; Benasutti, M; Essigmann, JM; Green, CL; Loechler, EL1
Schuchmann, HP; von Sonntag, C1
Leadon, SA2
Duker, NJ; Ganguly, T; Weems, KM1
Hegi, ME; Lutz, WK; Richter, C; Sagelsdorff, P; Ulrich, D1
Kow, YW; Van Houten, B; Wallace, SS1
Doetsch, PW; Lee, K; McCray, WH1
Laspia, MF; Wallace, SS2
Erlanger, BF; Huang, H; Hubbard, K; Ide, H; Laspia, MF; Wallace, SS1
Basu, AK; Essigmann, JM; Loechler, EL1
Wallace, SS3
Basu, AK; Essigmann, JM; Leadon, SA; Loechler, EL1
Lin, JJ; Sancar, A1
Beardsley, GP; Clark, JM3
Ganesan, AK; Hanawalt, PC; Leadon, SA; Meade, S; Spivak, G; Vos, JM1
Chan, A; Leadon, SA; Zimmerman, RJ1
Claycamp, HG; Smith, ST1
Smith, CA1
Adelman, R; Ames, BN; Saul, RL1
Alessio, H; Bergtold, DS; Cutler, RG; Simic, MG1
Ito, T; Kaneko, M; Leadon, SA1
Hayes, RC; Huang, HM; LeClerc, JE; Petrullo, LA; Wallace, SS1
Claycamp, HG1
Beardsley, GP; Clark, JM; Jarvis, W; Pattabiraman, N1
Schellenberg, KA; Shaeffer, J1
Essigmann, JM; Rouet, P1
Ide, H; Kow, YW; Wallace, SS1
Kaneko, M; Leadon, SA1
Hayes, RC; LeClerc, JE1
Ames, BN1
Ames, BN; Cathcart, R; Saul, RL; Schwiers, E1
Ide, H; Kagiya, T; Nishimoto, S; Wada, T1
Erlanger, BF; Laspia, MF; Melamede, RJ; Rajagopalan, R; Wallace, SS1
Hanawalt, PC; Leadon, SA1
Duker, NJ; Frenkel, K; Goldstein, MS; Teebor, GW1
Ward, JF; West, GJ; West, IW1
Frenkel, K; Goldstein, MS; Teebor, GW1
Hariharan, PV1
Barbee, SL; Dunn, AB; Leadon, SA1
Bockrath, R; Courcelle, J; Evans, J; Hatahet, Z; Ide, H; Maccabee, M; Wallace, S1
Miaskiewicz, K; Miller, J; Ornstein, R; Osman, R1
Fuciarelli, AF; Miller, DL; Sisk, EC; Thomas, RM1
Augeri, L; Doetsch, PW; Hamilton, KK; Martin, AM; Yohannes, P1
Ho, YS; Lin, JK; Lo, MJ; Wang, YJ1
Miaskiewicz, K; Miller, J; Osman, R1
Del Rowe, J; Franklin, WA; Minton, KW; Mun, C; Sandigursky, M1
Claycamp, HG; Luo, D1
Cao, EH; Wang, JJ1
Bolton, PH; Goljer, I; Kao, JY; Phan, TA1
Claycamp, HG; Huang, H1
Markey, CJ; Markey, SP; Wang, TC1
Bolton, PH; Boorstein, RJ; Cunningham, RP; Hilbert, TP; Kung, HC; Teebor, GW; Xing, D1
Ichikawa, N; Nagao, T; Tomikawa, S; Uchida, H; Watanabe, K1
Daniel, LN; Mao, Y; Markey, CJ; Markey, SP; Saffiotti, U; Shi, X; Wang, TC1
Anselmino, C; Lindahl, T; Roldán-Arjona, T1
Bolton, PH; Kung, HC1
Avrutskaya, AV; Leadon, SA2
Allalunis-Turner, J; Chen, D; Karimi-Busheri, F; Lee, J; Ruiqi, G; Weinfeld, M1
Ambulos, NP; Friedberg, EC; Malanoski, G; Radany, EH; Yasbin, RE1
Bolton, PH; Jerkovic, B; Kung, HC1
Bailey, E; Farmer, PB; Farooq, S; Hernández, H; Jukes, R; Lamb, JH; Sram, R; Topinka, J1
Bond, JP; Hatahet, Z; Lampman, GW; Purmal, AA; Wallace, SS1
Le, XC; Leadon, SA; Lee, J; Weinfeld, M; Xing, JZ2
Peters, R; Sikorski, R1
Basu, AK; Bolton, PH; Jerkovic, B; McNulty, JM1
Halliwell, B; Ince, PG; Jenner, A; Jenner, P; Lyras, L; Perry, EK; Perry, RH1
Avrutskaya, AV; Gowen, LC; Koller, BH; Latour, AM; Leadon, SA1
Akiyama, K; Bo, Z; Ide, H; Ikeda, S; Imai, K; Kubo, K; Nakano, H; Sarker, AH; Seki, S; Terato, H; Tsutsui, K; Yamamoto, K; Yasui, A; Yoshida, MC1
Buckley, TJ; Dizdaroglu, M; Karahalil, B; Roldán-Arjona, T; Sentürker, S1
Cadet, J; D'Ham, C; Gasparutto, D; Jaquinod, M; Romieu, A1
Alseth, I; Bjørås, M; Eide, L; Pirovano, M; Rognes, T; Seeberg, E1
Morimyo, M; Yasuhira, S; Yasui, A1
Funabiki, R; Miura, Y; Nagasawa, T; Shibasato, M; Takeshita, K1
Box, HC; Budzinski, EE; Dawidzik, JB; Ersing, N; Freund, HG; Iijima, H; Maccubbin, AE; Patrzyc, HB; Wallace, JC1
Bohr, VA; Dianov, GL; Dianova, II; Lipinski, LJ; Thybo, T1
Asagoshi, K; Asgarani, E; Ide, H; Ohyama, Y; Saito, T; Shahmohammadi, HR; Terato, H; Yamamoto, O1
Asagoshi, K; Ide, H; Miyano, T; Nakano, H; Odawara, H; Ohyama, Y; Seki, S; Terato, H1
Fujikawa, K; Kasai, H1
Okano, S; Yasui, A1
Cooper, PK; Lobrich, M; Rydberg, B1
Cooper, PK; Le, XC; Leadon, SA; Lee, J; Weinfeld, M; Xing, JZ1
Bentele, M; Hardeland, U; Jiricny, J; Lettieri, T; Schär, P; Steinacher, R1
Bohr, VA; Dianov, GL; Nyaga, SG; Souza-Pinto, N; Stevnsner, T; Thybo, T1
Aas, PA; Akbari, M; Andersen, S; Kavli, B; Krokan, HE; Nilsen, H; Otterlei, M; Skjelbred, C; Skorpen, F; Slupphaug, G1
Hanawalt, PC; Lloyd, DR; Maeda, LS; Reines, D; Tornaletti, S1
Bowman, KJ; Farmer, PB; Guichard, Y; Jones, GD; Pla, RL1
Iwai, S2
Burgess, S; Dizdaroglu, M; Dodson, ML; Jaruga, P; Lloyd, RS1
Bohr, VA; Brosh, RM; Christiansen, M; Citterio, E; May, A; Muftuoglu, M; Nyaga, S; Selzer, RR; Tuo, J1
Hanaoka, F; Iwai, S; Kusumoto, R; Masutani, C1
Wang, Y1
Hasegawa, R; Hoeijmakers, JH; Ide, H; Ikeda, S; Kanno, S; Kobayashi, K; Le, XC; Miyazaki, J; Muijtjens, M; Sarker, AH; Seki, S; Shiromoto, T; Takao, M; van der Horst, G; Weinfeld, M; Xing, JZ; Yasui, A1
Brooks, K; Miller, AC; Page, N; Shi, L; Stewart, M1
Feaver, WJ; Fischhaber, PL; Friedberg, EC; Gerlach, VL; Hatahet, Z; Wallace, SS1
Alanazi, M; Leadon, SA; Mellon, I1
Johnson, RE; Prakash, L; Prakash, S; Yu, SL1
Budworth, H; Dianov, GL1
Back, JH; Chung, JH; Han, YS; Kim, KS; Park, YI1
Hasegawa, A; Hoshino, M; Mizoi, M; Okada, S; Tachikawa, M; Yamanaka, K1
Iwai, S; O'Connor, TR; Pfeifer, GP; Yoon, JH1
Fernandes, AS; Grollman, AP; Iden, CR; McTigue, MM; Miller, H; Torres, MC; Wente, M; Zaika, E1
Kathe, SD; Shen, GP; Wallace, SS1
De Los Santos, CR; Iden, CR; McTigue, MM; Rieger, RA; Rosenquist, TA1
An, Y; Hoshino, M; Kato, K; Mizoi, M; Nakano, M; Okada, S; Takabayashi, F; Yamanaka, K1
Wang, Y; Zhang, Q1
Bahar, I; Iwai, S; Masutani, C; Schuffert, A; Seki, M; Wood, RD; Yang, LW1
Sugiyama, H; Takao, M; Yasui, A; Yonei, S; Yonekura, S; Zhang, QM1
Chaudhry, MA; Wallace, SS; Yang, N1
Hanawalt, PC; Spivak, G1
Iwai, S; Kawasaki, Y; Manabe, K; Shimizu, T; Yoshikawa, S1
Altamirano, A; Basu, AK; Boorstein, RJ; Chan, MK; Cummings, A; Cunningham, RP; Ocampo, JE; Ocampo-Hafalla, MT; Teebor, GW1
Bailey, DT; Box, HC; Budzinski, EE; Dawidzik, JB; DeFedericis, HC; Greene, KF; Iijima, H; Patrzyc, HB1
Box, HC; Budzinski, EE; Dawidzik, JB; DeFedericis, HC; Evans, MS; Greene, KF; Iijima, H; Patrzyc, HB; Rajecki, MJ1
Iwai, S; Shimizu, T; Takata, K; Wood, RD1
Ito, T; Kondo, A; Nishimoto, S; Terada, S1
Charlet-Berguerand, N; Conaway, JW; Conaway, R; Egly, JM; Feuerhahn, S; Kong, SE; Ziserman, H1
Hanaoka, F; Ide, H; Iwai, S; Katafuchi, A; Matsubara, M; Terato, H1
Fujiwara, Y; Inase, A; Iwai, S; Kawasaki, Y; Yoshikawa, S1
Handa, H; Hayashida, M; Ikegami, T; Ito, S; Kuraoka, I; Kwei, JS; Nakabeppu, Y; Suzuki, K; Tanaka, K1
Dabkowska, I; Gutowski, M; Haranczyk, M; Lupica, G1
Akiyama, M; Ide, H; Kubo, K; Matsuyama, S; Yamamoto, K; Yamamoto, R1
Bebenek, K; Blanco, L; Garcia-Diaz, M; Kunkel, TA; Povirk, LF; Zhou, RZ1
Adams, T; Basu, AK; Brown, KL; Jasti, VP; Stone, MP1
Goto, M; Igarashi, H; Iwaizumi, M; Kageyama, S; Kobayashi, M; Konno, H; Shinmura, K; Sugimura, H; Tsugane, S; Tsuneyoshi, T; Yamada, H1
Brosh, RM; Camerini-Otero, RD; Mason, AC; Sommers, JA; Suhasini, AN; Voloshin, ON; Wold, MS1
Bellon, S; Cunniffe, S; Lomax, M; O'Neill, P; Shikazono, N1
Chen, ZQ; Xue, Y; Zhang, CH1
Basu, AK; Brown, KL; Stone, MP1
Altamirano, A; Basu, AK; Brown, KL; Roginskaya, M; Stone, MP; Zou, Y1
Jiang, Y; Wang, Y; Yuan, B1
Belousova, EA; Fan, Y; Kubareva, EA; Lavrik, OI; Lebedeva, NA; Maga, G; Oretskaya, TS; Romanova, EA1
Chikuma, T; Katase, T; Kobayashi, S; Kotani, E; Takagi, A; Tamura, O1
Bhatia, G; Prakash, L; Prakash, S; Yoon, JH1
Azuara-Liceaga, E; Brieba, LG; Pastor-Palacios, G1
Doublié, S; Hogg, M; Seki, M; Wallace, SS; Wood, RD1
Aller, P; Doublié, S; Duclos, S; Wallace, SS1
Couve, S; Gasparutto, D; Ishchenko, AA; Mazouzi, A; Redrejo-Rodríguez, M; Saint-Pierre, C; Saparbaev, M1
Averill, A; Doublié, S; Imamura, K; Wallace, SS1
Bohr, VA; Croteau, DL; Ghosh, AK; Janscak, P; Kulikowicz, T; Popuri, V; Ramamoorthy, M; Rossi, ML; Shevelev, I; Singh, DK1
Hashiguchi, K; Igarashi, K; Kato, S; Moriwaki, T; Yonekura, S; Zhang-Akiyama, QM1
Buckle, M; Fedorova, OS; Gasparutto, D; Ishchenko, AA; Leh, H; Prorok, P; Saint-Pierre, C; Saparbaev, M; Tudek, B1
Akopiants, K; Hromas, RA; Lee, SH; Menon, V; Mohapatra, S; Povirk, LF; Ramsden, DA; Yannone, SM1
Bohr, VA; Canugovi, C; Croteau, DL; Ferrarelli, LK; Ghosh, AK; Hsu, JK; Popuri, V; Tadokoro, T1
Maher, RL; Pederson, DS; Prasad, A; Rizvanova, O; Wallace, SS1
Chen, ZQ; Liu, XQ; Xue, Y1
Park, J; Prakash, L; Prakash, S; Roy Choudhury, J; Yoon, JH1
Bohr, VA; Canugovi, C; Croteau, DL; Ghosh, S; Mattson, MP; Wilson, DM; Yoon, JS1
Breslauer, KJ; Grollman, AP; Iden, CR; Johnson, F; Minetti, CA; Remeta, DP1
Akopiants, K; Almohaini, M; Bafail, D; Chalasani, SL; Hartman, MCT; Povirk, LF; Ramsden, DA; Yannone, SM; Zhou, T1
Barrientos, C; Bitar, M; Cabrera, G; Galanti, N; Kemmerling, U; Machado, CR; Ormeño, F; Ponce, I; Ramirez, S; Sepúlveda, S; Valenzuela, L1
Gao, YQ; Liu, M; Lu, L; Song, J; Stovicek, O; Yi, C; Yue, Z; Zhang, J; Zhu, C; Zong, S1
Li, ZS; Zhang, RB; Zhao, S1
Calkins, MJ; Dizdaroglu, M; Jaruga, P; Kirkali, G; Lloyd, RS; McCullough, AK; Owen, N; Vartanian, V1
Bose, A; Lee, CY; Lee, HT; Myong, S; Opresko, PL1
Brenerman, B; Golato, T; Li, J; McNeill, DR; Sobol, RW; Wilson, DM1
Boldinova, EO; Ignatov, A; Kulbachinskiy, A; Makarova, AV1
DAS, P; Kumari, B; Sinha, KK1
Albelazi, MS; Elder, RH; Martin, PR; Mohammed, S; Mutti, L; Parsons, JL1
Clivio, P; Coantic-Castex, S; Guillaume, D; Harakat, D; Martinez, A1
Basu, AK; Greenberg, MM; Huang, H; Naldiga, S1
Baruch-Torres, N; Brieba, LG; Iwai, S; Juárez-Quintero, V; Yamamoto, J1
Iwai, S; Mizutani, K; Shiraishi, M; Yamamoto, J1
Kumar, N; Raja, S; Van Houten, B1
Guilliam, TA; Yeeles, JT1
Anderson-Steele, BM; David, SS; Lotsof, ER; Yeo, J1
Kazempour, A; Mohammadi-Manesh, H; Mohammadtabar, F; Rajaie Khorasani, R1
Akamatsu, K; Inamura, D; Nakano, T; Nishizawa, S; Sato, Y; Takaku, Y1

Reviews

11 review(s) available for thymine glycol and thymine

ArticleYear
Biomarkers of OH radical damage in vivo.
    Free radical research communications, 1991, Volume: 12-13 Pt 1

    Topics: Biomarkers; DNA; Free Radicals; Hydroxides; Hydroxyl Radical; Hydroxylation; Phenylalanine; Proteins; Thymine; Thymine Nucleotides; Tyrosine

1991
The role of carcinogen DNA adduct structure in the induction of mutations.
    Progress in clinical and biological research, 1990, Volume: 340A

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; DNA; DNA Adducts; DNA Damage; Guanine; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Thymine

1990
Production and repair of DNA damage in mammalian cells.
    Health physics, 1990, Volume: 59, Issue:1

    Topics: Animals; Carcinogens; Cell Cycle; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Humans; Thymine

1990
The detection of environmental mutagens and potential carcinogens.
    Cancer, 1984, May-15, Volume: 53, Issue:10

    Topics: Aging; Animals; Biological Assay; Biotransformation; Carcinogens, Environmental; DNA; DNA Repair; Female; Free Radicals; Humans; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Neoplasms; Oxidation-Reduction; Rats; Salmonella typhimurium; Thymine; Uric Acid

1984
[Oxidative DNA damage].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2001, Volume: 46, Issue:8 Suppl

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenosine Triphosphate; Animals; Deoxyguanosine; DNA; DNA Damage; DNA Repair; DNA Replication; Humans; Mutation; Oxidative Stress; Reactive Oxygen Species; Thymine

2001
[Repair networks for base damage and single-strand breaks].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2001, Volume: 46, Issue:8 Suppl

    Topics: Animals; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Single-Stranded; Guanine; Humans; Poly(ADP-ribose) Polymerases; Thymine; X-ray Repair Cross Complementing Protein 1

2001
Factors influencing the removal of thymine glycol from DNA in gamma-irradiated human cells.
    Progress in nucleic acid research and molecular biology, 2001, Volume: 68

    Topics: Animals; Cells, Cultured; Cockayne Syndrome; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Circular; DNA, Recombinant; Dose-Response Relationship, Radiation; Electrophoresis, Capillary; Endonucleases; Fluorescent Antibody Technique, Indirect; Gamma Rays; Humans; Lymphocyte Activation; Lymphocytes; Mice; Nuclear Proteins; Plasmids; Rats; Resting Phase, Cell Cycle; Sensitivity and Specificity; Thymine; Transcription Factors; Xeroderma Pigmentosum

2001
Thymine DNA glycosylase.
    Progress in nucleic acid research and molecular biology, 2001, Volume: 68

    Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Pair Mismatch; Base Sequence; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytosine; Deamination; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; DNA, Neoplasm; Endodeoxyribonucleases; Evolution, Molecular; Guanine; Humans; Mice; Models, Genetic; Molecular Sequence Data; Receptors, Retinoic Acid; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity; Thymine; Transcription, Genetic; Transfection; Uracil

2001
Base excision repair in nuclear and mitochondrial DNA.
    Progress in nucleic acid research and molecular biology, 2001, Volume: 68

    Topics: Adenine; Aging; Animals; Base Sequence; Cell Line; Cell Nucleus; Cell-Free System; DNA; DNA Damage; DNA Glycosylases; DNA Polymerase beta; DNA Repair; DNA-Formamidopyrimidine Glycosylase; DNA, Mitochondrial; Guanine; Hypoxanthine; Lymphocytes; Mammals; Mice; Mitochondria; Molecular Sequence Data; N-Glycosyl Hydrolases; Oxidants; Oxidation-Reduction; Oxidative Stress; Point Mutation; Proliferating Cell Nuclear Antigen; Rats; Thymine

2001
Properties and functions of human uracil-DNA glycosylase from the UNG gene.
    Progress in nucleic acid research and molecular biology, 2001, Volume: 68

    Topics: Animals; Apurinic Acid; Bacterial Proteins; Binding Sites; Catalytic Domain; Cell Cycle; Chromosome Mapping; Chromosomes, Human, Pair 12; Deoxyribonuclease (Pyrimidine Dimer); Deoxyuracil Nucleotides; DNA Glycosylases; DNA Repair; DNA, Mitochondrial; Endodeoxyribonucleases; Escherichia coli; Gene Expression Regulation, Enzymologic; Genes; Humans; Mice; Mice, Knockout; Mitochondria; Multigene Family; N-Glycosyl Hydrolases; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pyrimidines; Thymine; Uracil-DNA Glycosidase

2001
The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage.
    Nucleic acids research, 2020, 11-18, Volume: 48, Issue:20

    Topics: 5-Methylcytosine; DNA Damage; DNA Repair; DNA-Binding Proteins; Guanine; Humans; Oxidation-Reduction; Oxidative Stress; Thymine; Xeroderma Pigmentosum

2020

Other Studies

171 other study(ies) available for thymine glycol and thymine

ArticleYear
Melanin both causes and prevents oxidative base damage in DNA: quantification by anti-thymine glycol antibody.
    Radiation research, 1992, Volume: 130, Issue:2

    Topics: Antibodies; Cross Reactions; DNA; DNA Damage; Free Radicals; Melanins; Radiation Dosage; Thymine

1992
Relationship of resistance to oxygen free radicals to CuZn-superoxide dismutase activity in transgenic, transfected, and trisomic cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1992, Feb-01, Volume: 6, Issue:3

    Topics: Animals; Catalase; Cell Survival; Cells, Cultured; DNA; DNA Damage; Dose-Response Relationship, Drug; Free Radicals; Glutathione Peroxidase; HeLa Cells; Humans; In Vitro Techniques; Mice; Mice, Transgenic; Paraquat; Superoxide Dismutase; Thymine; Transfection; Trisomy

1992
32P-postlabeling detection of radiation-induced DNA damage: identification and estimation of thymine glycols and phosphoglycolate termini.
    Biochemistry, 1991, Jan-29, Volume: 30, Issue:4

    Topics: Adenosine Triphosphate; Alkaline Phosphatase; Deoxyribonuclease I; DNA; DNA Damage; DNA Repair; Genetic Markers; Glycolates; Hydrolysis; Hydroxides; Hydroxyl Radical; Osmium Tetroxide; Phosphodiesterase I; Phosphoric Diester Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Polynucleotide 5'-Hydroxyl-Kinase; Pyrimidine Dimers; T-Phages; Thymine; X-Rays

1991
Thymine glycols and pyrimidine dimers in brain DNA during post-ischemic reperfusion.
    Resuscitation, 1991, Volume: 21, Issue:1

    Topics: Animals; Brain Ischemia; DNA; DNA Damage; Dogs; Enzyme-Linked Immunosorbent Assay; Free Radicals; Pyrimidine Dimers; Reperfusion Injury; Thymine; Transcription, Genetic

1991
32P-postlabeling detection of thymine glycols: evaluation of adduct recoveries after enhancement with affinity chromatography, nuclease P1, nuclease S1, and polynucleotide kinase.
    Cancer communications, 1991, Volume: 3, Issue:4

    Topics: Adenosine Triphosphate; Autoradiography; Benzene; Chromatography, Affinity; Chromatography, Thin Layer; DNA; DNA Damage; Dose-Response Relationship, Drug; In Vitro Techniques; Osmium Tetroxide; Phosphorus Radioisotopes; Polynucleotide 5'-Hydroxyl-Kinase; Single-Strand Specific DNA and RNA Endonucleases; Thymine

1991
Radical-mediated DNA damage in presence of oxygen.
    Methods in enzymology, 1990, Volume: 186

    Topics: Alkaline Phosphatase; Deoxyribonuclease I; Deoxyribonucleosides; DNA Damage; DNA Repair; Escherichia coli; Free Radicals; Hydrolysis; Methods; Micrococcus; Oxidation-Reduction; Oxygen; Phosphoric Diester Hydrolases; Thymine

1990
Ultraviolet-induced thymine hydrates in DNA are excised by bacterial and human DNA glycosylase activities.
    Biochemistry, 1990, Aug-07, Volume: 29, Issue:31

    Topics: Bacterial Proteins; Cells, Cultured; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Glycosylases; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Fibroblasts; Humans; N-Glycosyl Hydrolases; Poly dA-dT; Thymine; Ultraviolet Rays

1990
No measurable increase in thymidine glycol or 8-hydroxydeoxyguanosine in liver DNA of rats treated with nafenopin or choline-devoid low-methionine diet.
    Mutation research, 1990, Volume: 238, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Deoxyguanosine; DNA; DNA Damage; Electrochemistry; Liver; Male; Methionine; Nafenopin; Propionates; Rats; Rats, Inbred F344; Thymine

1990
UvrABC nuclease complex repairs thymine glycol, an oxidative DNA base damage.
    Mutation research, 1990, Volume: 235, Issue:2

    Topics: Apurinic Acid; Bacteriophages; DNA Repair; DNA, Viral; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Fluorometry; Gram-Negative Aerobic Bacteria; Hydroxylamines; Oxidation-Reduction; Substrate Specificity; Thymine; Transduction, Genetic; Transfection

1990
Thymine glycol-DNA glycosylase/AP endonuclease of CEM-C1 lymphoblasts: a human analog of Escherichia coli endonuclease III.
    Biochemical and biophysical research communications, 1987, Nov-30, Volume: 149, Issue:1

    Topics: Cations, Divalent; Cell Line; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; Lymphocytes; Molecular Weight; Osmium Tetroxide; Thymine; Ultraviolet Rays

1987
Excision repair of thymine glycols, urea residues, and apurinic sites in Escherichia coli.
    Journal of bacteriology, 1988, Volume: 170, Issue:8

    Topics: Coliphages; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Exodeoxyribonucleases; Mutation; SOS Response, Genetics; Substrate Specificity; Thymine; Transfection; Ultraviolet Rays; Urea

1988
Immunochemical quantitation of thymine glycol in oxidized and X-irradiated DNA.
    Radiation research, 1989, Volume: 118, Issue:2

    Topics: Bacteriophage phi X 174; DNA; DNA Damage; DNA, Bacterial; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Osmium Tetroxide; Oxidation-Reduction; Thymine

1989
SOS processing of unique oxidative DNA damages in Escherichia coli.
    Journal of molecular biology, 1989, May-05, Volume: 207, Issue:1

    Topics: Binding Sites; Coliphages; DNA Damage; DNA, Bacterial; Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Glycosides; Mutation; Oxidation-Reduction; Thymine; Transfection; Urea

1989
Mutagenic specificity of alkylated and oxidized DNA bases as determined by site-specific mutagenesis.
    Annali dell'Istituto superiore di sanita, 1989, Volume: 25, Issue:1

    Topics: DNA Mutational Analysis; DNA, Bacterial; Escherichia coli; Guanine; Mutation; Thymine

1989
Processing of ring saturation and fragmentation products of DNA thymine in Escherichia coli.
    Annali dell'Istituto superiore di sanita, 1989, Volume: 25, Issue:1

    Topics: DNA Damage; Escherichia coli; Thymine

1989
Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:20

    Topics: Base Sequence; Coliphages; DNA Replication; Escherichia coli; Genes, Viral; Models, Genetic; Models, Molecular; Mutagens; Mutation; Nucleic Acid Conformation; Thymine

1989
A new mechanism for repairing oxidative damage to DNA: (A)BC excinuclease removes AP sites and thymine glycols from DNA.
    Biochemistry, 1989, Oct-03, Volume: 28, Issue:20

    Topics: DNA Damage; DNA Repair; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Kinetics; Oxidation-Reduction; Plasmids; Thymine

1989
Template length, sequence context, and 3'-5' exonuclease activity modulate replicative bypass of thymine glycol lesions in vitro.
    Biochemistry, 1989, Jan-24, Volume: 28, Issue:2

    Topics: Base Sequence; DNA Damage; DNA Polymerase I; DNA Polymerase II; DNA Replication; DNA-Directed DNA Polymerase; Exodeoxyribonuclease V; Exodeoxyribonucleases; HeLa Cells; Humans; Oligodeoxyribonucleotides; Templates, Genetic; Thymine

1989
Enhanced transforming activity of pSV2 plasmids in human cells depends upon the type of damage introduced into the plasmid.
    Mutation research, 1988, Volume: 193, Issue:2

    Topics: Cell Line; DNA Damage; Escherichia coli; Humans; Plasmids; Pyrimidine Dimers; Simian virus 40; Thymine; Transformation, Genetic; Ultraviolet Rays

1988
Oxidative damage in murine tumor cells treated in vitro by recombinant human tumor necrosis factor.
    Cancer research, 1989, Apr-01, Volume: 49, Issue:7

    Topics: Animals; DNA Damage; Drug Resistance; Glutathione; Hydrogen Peroxide; Mice; Oxidation-Reduction; Recombinant Proteins; Thymine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1989
Absence of pyrimidine salvage and prevention of thymineless radiosensitization in Escherichia coli thyA cells fed dihydrothymine or thymine glycol.
    Radiation research, 1988, Volume: 115, Issue:3

    Topics: Dose-Response Relationship, Radiation; Escherichia coli; Mutation; Pyrimidines; Thymine

1988
DNA repair in specific sequences in mammalian cells.
    Journal of cell science. Supplement, 1987, Volume: 6

    Topics: Acetoxyacetylaminofluorene; Aflatoxins; Animals; Base Sequence; Cells, Cultured; Cricetinae; Cricetulus; DNA; DNA Repair; Furocoumarins; Haplorhini; Humans; Mice; Proto-Oncogene Mas; Thymine; Ultraviolet Rays

1987
Oxidative damage to DNA: relation to species metabolic rate and life span.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:8

    Topics: Aging; Animals; DNA Damage; Energy Metabolism; Glycols; Haplorhini; Mice; Oxidation-Reduction; Thymidine; Thymine

1988
Urine biomarkers for oxidative DNA damage.
    Basic life sciences, 1988, Volume: 49

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Deoxyguanosine; DNA Damage; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Mice; Rats; Thymidine; Thymine

1988
Relationship between the induction of mitotic gene conversion and the formation of thymine glycols in yeast S. cerevisiae treated with hydrogen peroxide.
    Mutation research, 1988, Volume: 207, Issue:1

    Topics: Antibodies, Monoclonal; Dose-Response Relationship, Drug; Gene Conversion; Hydrogen Peroxide; Mitosis; Saccharomyces cerevisiae; Thymine; Tryptophan

1988
Oxidative damage in DNA. Lack of mutagenicity by thymine glycol lesions.
    Journal of molecular biology, 1988, May-20, Volume: 201, Issue:2

    Topics: Base Sequence; Coliphages; DNA Damage; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Mutation; Osmium Tetroxide; Thymine

1988
Production of thymine glycols in DNA by radiation and chemical carcinogens as detected by a monoclonal antibody.
    The British journal of cancer. Supplement, 1987, Volume: 8

    Topics: 2-Naphthylamine; Antibodies, Monoclonal; Benzopyrenes; Carcinogens; Cells, Cultured; DNA; DNA Damage; Fibroblasts; Humans; Thymine; Ultraviolet Rays

1987
The biological consequences of oxidized DNA bases.
    The British journal of cancer. Supplement, 1987, Volume: 8

    Topics: Bacteriophages; DNA Damage; DNA, Viral; Models, Biological; Models, Molecular; Thymine; Urea

1987
Thymine glycol lesions terminate chain elongation by DNA polymerase I in vitro.
    Nucleic acids research, 1986, Jan-24, Volume: 14, Issue:2

    Topics: Base Sequence; Coliphages; DNA Polymerase I; DNA-Directed DNA Polymerase; DNA, Circular; DNA, Single-Stranded; Escherichia coli; T-Phages; Templates, Genetic; Thymine

1986
Dithiothreitol-induced oxidative damage to thymine and DNA in solution.
    Biochemical and biophysical research communications, 1987, Apr-14, Volume: 144, Issue:1

    Topics: Dithiothreitol; DNA Damage; DNA, Bacterial; Free Radicals; In Vitro Techniques; Oxidation-Reduction; Solutions; Thymine

1987
Functional effects of cis-thymine glycol lesions on DNA synthesis in vitro.
    Biochemistry, 1987, Aug-25, Volume: 26, Issue:17

    Topics: Base Sequence; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; HeLa Cells; Humans; Oligodeoxyribonucleotides; Stereoisomerism; T-Phages; Thymine

1987
Modeling and molecular mechanical studies of the cis-thymine glycol radiation damage lesion in DNA.
    Biochemistry, 1987, Aug-25, Volume: 26, Issue:17

    Topics: Base Sequence; DNA; DNA Damage; Models, Molecular; Nucleic Acid Conformation; Stereoisomerism; Thymine

1987
Formation of methyl ester of 2-methylglyceric acid from thymine glycol residues: a convenient new method for determining radiation damage to DNA.
    Biochemistry, 1986, Apr-08, Volume: 25, Issue:7

    Topics: Animals; Borohydrides; Cell Line; Cricetinae; Cricetulus; DNA; Female; Glyceric Acids; Magnetic Resonance Spectroscopy; Ovary; Thymine; Tritium; X-Rays

1986
Possible role for thymine glycol in the selective inhibition of DNA synthesis on oxidized DNA templates.
    Cancer research, 1985, Volume: 45, Issue:12 Pt 1

    Topics: Coliphages; DNA; DNA Polymerase I; DNA Replication; DNA, Single-Stranded; Escherichia coli; Oxidation-Reduction; Potassium Permanganate; Templates, Genetic; Thymine; Virus Replication

1985
Thymine glycols and urea residues in M13 DNA constitute replicative blocks in vitro.
    Nucleic acids research, 1985, Nov-25, Volume: 13, Issue:22

    Topics: Bacterial Proteins; Coliphages; DNA Replication; DNA-Directed DNA Polymerase; DNA, Single-Stranded; DNA, Viral; Escherichia coli; Osmium Tetroxide; T-Phages; Templates, Genetic; Thymine; Urea; Viral Proteins; Virus Replication

1985
Production of thymine glycols in DNA by N-hydroxy-2-naphthylamine as detected by a monoclonal antibody.
    Cancer research, 1986, Volume: 46, Issue:1

    Topics: 2-Naphthylamine; Antibodies, Monoclonal; Catalase; Cells, Cultured; DNA Repair; Dose-Response Relationship, Drug; Free Radicals; Glycols; Humans; Naphthalenes; Superoxide Dismutase; Thymine; Xeroderma Pigmentosum

1986
Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase I.
    Nucleic acids research, 1986, Jan-24, Volume: 14, Issue:2

    Topics: Base Sequence; Coliphages; DNA Polymerase I; DNA, Single-Stranded; DNA, Viral; Osmium Tetroxide; Substrate Specificity; Templates, Genetic; Thymine

1986
Detection and repair of DNA base damages produced by ionizing radiation.
    Environmental mutagenesis, 1983, Volume: 5, Issue:5

    Topics: Coliphages; Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Repair; DNA Replication; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Viral; Dose-Response Relationship, Radiation; Endodeoxyribonucleases; Genes, Viral; Immunoenzyme Techniques; Kinetics; Radiation, Ionizing; Substrate Specificity; Thymine

1983
Thymine glycol and thymidine glycol in human and rat urine: a possible assay for oxidative DNA damage.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:18

    Topics: Animals; Chromatography, High Pressure Liquid; DNA Replication; Germ-Free Life; Glucose; Humans; Rats; Species Specificity; Spectrophotometry, Ultraviolet; Thymidine; Thymine; Tritium

1984
Radiation-induced hydroxylation of thymine promoted by electron-affinic compounds.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1983, Volume: 44, Issue:6

    Topics: Air; Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Gamma Rays; Hydroxylation; Nitrobenzenes; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Quinones; Radiation-Sensitizing Agents; Solutions; Thymine; Water

1983
Properties of antibodies to thymine glycol, a product of the radiolysis of DNA.
    Radiation research, 1984, Volume: 97, Issue:3

    Topics: Animals; Antibody Formation; Antibody Specificity; DNA; Enzyme-Linked Immunosorbent Assay; Rabbits; Thymine

1984
Monoclonal antibody to DNA containing thymine glycol.
    Mutation research, 1983, Volume: 112, Issue:4

    Topics: Animals; Antibodies, Monoclonal; DNA; DNA, Bacterial; Enzyme-Linked Immunosorbent Assay; Hybridomas; Lymphocytes; Mice; Mice, Inbred BALB C; Plasmacytoma; Poly T; Thymine; Thymus Gland; Ultraviolet Rays

1983
Identification of the cis-thymine glycol moiety in oxidized deoxyribonucleic acid.
    Biochemistry, 1981, Feb-17, Volume: 20, Issue:4

    Topics: Chemical Phenomena; Chemistry; DNA, Bacterial; Escherichia coli; Oxidation-Reduction; Potassium Permanganate; Thymidine; Thymine

1981
Radioimmunoassay of a thymine glycol.
    Radiation research, 1982, Volume: 90, Issue:3

    Topics: Animals; Rabbits; Radioimmunoassay; Thymine

1982
Identification of the cis-thymine glycol moiety in chemically oxidized and gamma-irradiated deoxyribonucleic acid by high-pressure liquid chromatography analysis.
    Biochemistry, 1981, Dec-22, Volume: 20, Issue:26

    Topics: Chromatography, High Pressure Liquid; DNA; Gamma Rays; Oxidation-Reduction; Thymidine; Thymine

1981
Determination of thymine ring saturation products of the 5,6-dihydroxydihydrothymine type by the alkali degradation assay.
    Radiation research, 1980, Volume: 81, Issue:3

    Topics: Alkalies; Cobalt Radioisotopes; DNA Repair; DNA, Bacterial; Gamma Rays; Hot Temperature; Micrococcus; Thymine

1980
The yeast RAD2, but not RAD1, gene is involved in the transcription-coupled repair of thymine glycols.
    Mutation research, 1995, Volume: 337, Issue:3

    Topics: DNA Probes; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Endodeoxyribonucleases; Endonucleases; Enzyme-Linked Immunosorbent Assay; Fungal Proteins; Genes, Fungal; Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thymine; Time Factors; Transcription, Genetic

1995
Thymine ring saturation and fragmentation products: lesion bypass, misinsertion and implications for mutagenesis.
    Mutation research, 1993, Volume: 299, Issue:3-4

    Topics: Base Sequence; DNA Damage; DNA Polymerase I; DNA Replication; DNA, Single-Stranded; Escherichia coli; Free Radicals; Glycosides; Molecular Sequence Data; Mutagenesis; Pyrimidines; Thymine; Transfection; Urea

1993
Molecular dynamics simulations of the effects of ring-saturated thymine lesions on DNA structure.
    Biopolymers, 1995, Volume: 35, Issue:1

    Topics: Base Sequence; Computer Simulation; DNA; DNA Damage; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Solvents; Structure-Activity Relationship; Thymine

1995
Induction of base damage in DNA solutions by ultrasonic cavitation.
    Free radical biology & medicine, 1995, Volume: 18, Issue:2

    Topics: Adenine; Animals; Cattle; Cytosine; DNA Damage; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydrogen Peroxide; Hydroxyl Radical; Purines; Pyrimidines; Thymine; Ultrasonics

1995
Purification and properties of yeast redoxyendonuclease.
    Methods in enzymology, 1994, Volume: 234

    Topics: Base Sequence; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chromatography, Liquid; Deoxyadenine Nucleotides; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; Endodeoxyribonucleases; Indicators and Reagents; Molecular Sequence Data; Molecular Weight; Phosphorus Radioisotopes; Radioisotope Dilution Technique; Restriction Mapping; Saccharomyces cerevisiae; Substrate Specificity; Thymine

1994
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
    Chemico-biological interactions, 1995, Volume: 94, Issue:2

    Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA Damage; DNA, Neoplasm; Gas Chromatography-Mass Spectrometry; Guanine; Hydrolysis; Liver; Liver Neoplasms, Experimental; Lung; Lung Neoplasms; Male; Methylamines; Nitrates; Oxidation-Reduction; Pyrimidines; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thymine; Uracil

1995
Ab initio theoretical study of the structures of thymine glycol and dihydrothymine.
    International journal of radiation biology, 1993, Volume: 63, Issue:6

    Topics: DNA; DNA Damage; Free Radicals; Thymine

1993
DNA deoxyribophosphodiesterase and an activity that cleaves DNA containing thymine glycol adducts in Deinococcus radiodurans.
    Radiation research, 1994, Volume: 138, Issue:2

    Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; DNA Damage; DNA Repair; DNA, Bacterial; Electrophoresis, Agar Gel; Gram-Positive Cocci; Hydrolysis; Phosphoric Diester Hydrolases; Thymine

1994
Plutonium-catalyzed oxidative DNA damage in the absence of significant alpha-particle decay.
    Radiation research, 1994, Volume: 137, Issue:1

    Topics: Alpha Particles; Animals; Ascorbic Acid; Cattle; DNA; DNA Damage; Hydrogen Peroxide; Hydrogen-Ion Concentration; Iron; Kinetics; Oxidation-Reduction; Plutonium; Thymine

1994
Oxidative damage to DNA: levels of thymine glycol and thymidine glycol in neoplastic human urines.
    Carcinogenesis, 1993, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Aged; DNA Damage; DNA Repair; Female; Humans; Male; Middle Aged; Neoplasms; Oxidation-Reduction; Thymidine; Thymine

1993
Characterization of the effects of a thymine glycol residue on the structure, dynamics, and stability of duplex DNA by NMR.
    The Journal of biological chemistry, 1993, Aug-25, Volume: 268, Issue:24

    Topics: Base Sequence; Chromatography, High Pressure Liquid; DNA; Drug Stability; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oxidation-Reduction; Thymine

1993
Zinc deficiency in antibody-conjugated alkaline phosphatase inhibits enzyme activity in ELISAs.
    BioTechniques, 1993, Volume: 14, Issue:3

    Topics: Alkaline Phosphatase; Animals; Biotechnology; Buffers; DNA Damage; Enzyme-Linked Immunosorbent Assay; Glycine; Thymine; Zinc

1993
Oxidative damage in double-stranded genomic DNA as measured by GC/MS assay of a thymine glycol derivative.
    Annals of the New York Academy of Sciences, 1993, May-28, Volume: 679

    Topics: Animals; Base Composition; Base Sequence; Biomarkers; Cells, Cultured; DNA; DNA Damage; Free Radicals; Gas Chromatography-Mass Spectrometry; Genes; Oxidation-Reduction; Thymine

1993
Purification of a mammalian homologue of Escherichia coli endonuclease III: identification of a bovine pyrimidine hydrate-thymine glycol DNAse/AP lyase by irreversible cross linking to a thymine glycol-containing oligoxynucleotide.
    Biochemistry, 1996, Feb-27, Volume: 35, Issue:8

    Topics: Amino Acid Sequence; Animals; Base Sequence; Cattle; Cross-Linking Reagents; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA Glycosylases; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; In Vitro Techniques; Lyases; Molecular Sequence Data; Molecular Weight; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Oxidation-Reduction; Rats; Sequence Homology, Amino Acid; Substrate Specificity; Thymine

1996
Damage and repair of DNA after liver transplantation assessed by urinary thymine glycol output.
    Transplantation proceedings, 1996, Volume: 28, Issue:3

    Topics: Animals; Biomarkers; DNA Damage; DNA Repair; Liver; Liver Transplantation; Male; Organ Preservation; Rats; Rats, Inbred ACI; Rats, Inbred Lew; Thymine; Time Factors; Transplantation, Homologous; Transplantation, Isogeneic

1996
DNA strand breakage, thymine glycol production, and hydroxyl radical generation induced by different samples of crystalline silica in vitro.
    Environmental research, 1995, Volume: 71, Issue:1

    Topics: Animals; Crystallization; DNA Damage; Electron Spin Resonance Spectroscopy; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyl Radical; Oxygen; Silicon Dioxide; Thymine

1995
Molecular cloning and functional analysis of a Schizosaccharomyces pombe homologue of Escherichia coli endonuclease III.
    Nucleic acids research, 1996, Sep-01, Volume: 24, Issue:17

    Topics: Amino Acid Sequence; Cloning, Molecular; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli Proteins; Eukaryotic Cells; Lyases; Molecular Sequence Data; N-Glycosyl Hydrolases; Recombinant Proteins; Schizosaccharomyces; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Thymine; Urea

1996
Structure of a duplex DNA containing a thymine glycol residue in solution.
    The Journal of biological chemistry, 1997, Apr-04, Volume: 272, Issue:14

    Topics: Chromatography, High Pressure Liquid; DNA; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Surface Properties; Thymine

1997
Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.
    Cancer research, 1997, Sep-01, Volume: 57, Issue:17

    Topics: Adaptor Proteins, Signal Transducing; Carrier Proteins; Cell Survival; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Neoplasm; Humans; Metallothionein; Mutation; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; Proto-Oncogene Proteins; Thymine; Transcription, Genetic; Tumor Cells, Cultured

1997
Use of a postlabelling assay to examine the removal of radiation-induced DNA lesions by purified enzymes and human cell extracts.
    Mutation research, 1997, Aug-01, Volume: 378, Issue:1-2

    Topics: Cell Extracts; Cell Survival; Deoxyribonuclease I; Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Single-Stranded; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Gamma Rays; Glycolates; Humans; Lyases; Magnesium; Nucleic Acid Denaturation; Phosphorus Radioisotopes; Thymine; Tumor Cells, Cultured

1997
Transfection enhancement in Bacillus subtilis displays features of a novel DNA repair pathway. I: DNA base and nucleolytic specificity.
    Mutation research, 1997, Volume: 384, Issue:2

    Topics: Bacillus subtilis; Bacteriophages; Base Composition; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli Proteins; N-Glycosyl Hydrolases; Pentoxyl; Pyrimidines; Substrate Specificity; Thymine; Transfection; Ultraviolet Rays; Uracil-DNA Glycosidase

1997
Purification of thymine glycol DNA and nucleosides by use of boronate chromatography.
    Analytical biochemistry, 1998, Jan-01, Volume: 255, Issue:1

    Topics: Boron Compounds; Chromatography, High Pressure Liquid; DNA; DNA Damage; Thymidine; Thymine

1998
Determination of cis-thymine glycol in DNA by gas chromatography-mass spectrometry with selected ion recording and multiple reaction monitoring.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Nov-21, Volume: 702, Issue:1-2

    Topics: Acetamides; Animals; Antioxidants; Calibration; Cattle; DNA; Female; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Humans; Hydrolysis; Organosilicon Compounds; Osmolar Concentration; Placenta; Pregnancy; Reference Standards; Stereoisomerism; Thymine; Thymus Gland; Trifluoroacetic Acid; Tritium

1997
Enzymatic processing of uracil glycol, a major oxidative product of DNA cytosine.
    The Journal of biological chemistry, 1998, Apr-17, Volume: 273, Issue:16

    Topics: Adenosine Triphosphate; Base Composition; Base Sequence; Cytosine; Deoxyadenine Nucleotides; DNA; DNA Damage; DNA Polymerase I; DNA Primers; DNA Repair; Escherichia coli; Kinetics; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oxidation-Reduction; Templates, Genetic; Thymine; Uracil

1998
Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage.
    Science (New York, N.Y.), 1998, May-15, Volume: 280, Issue:5366

    Topics: Antibodies, Monoclonal; Bromodeoxyuridine; DNA Damage; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Radiation; Electrophoresis, Capillary; Humans; Radiation, Ionizing; Thymine; Tumor Cells, Cultured

1998
Zeptomolar damage.
    Science (New York, N.Y.), 1998, May-15, Volume: 280, Issue:5366

    Topics: Antibodies, Monoclonal; DNA Damage; DNA Repair; DNA, Neoplasm; Electrophoresis, Capillary; Fluorescent Dyes; Humans; Radiation, Ionizing; Sensitivity and Specificity; Thymine; Tumor Cells, Cultured

1998
Replication inhibition and miscoding properties of DNA templates containing a site-specific cis-thymine glycol or urea residue.
    Chemical research in toxicology, 1998, Volume: 11, Issue:6

    Topics: DNA; DNA Damage; DNA Replication; Humans; Thymine; Urea

1998
Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae.
    Mutation research, 1998, Volume: 407, Issue:2

    Topics: DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Fungal; Fungal Proteins; Genes, Fungal; Genome, Fungal; Pyrimidine Dimers; Saccharomyces cerevisiae; Thymine; Transcription, Genetic

1998
Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies.
    Journal of neurochemistry, 1998, Volume: 71, Issue:1

    Topics: Adenine; Aged; Aged, 80 and over; Alzheimer Disease; Brain Chemistry; Cerebral Cortex; Cytosine; DNA; Guanine; Humans; Hydantoins; Hypoxanthine; Lewy Bodies; Lipid Peroxidation; Middle Aged; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Thymine; Uracil; Xanthine

1998
BRCA1 required for transcription-coupled repair of oxidative DNA damage.
    Science (New York, N.Y.), 1998, Aug-14, Volume: 281, Issue:5379

    Topics: Alleles; Animals; BRCA1 Protein; Cell Line; DNA Damage; DNA Repair; Hydrogen Peroxide; Mice; Oxidation-Reduction; Stem Cells; Thymine; Transcription, Genetic; Ultraviolet Rays

1998
Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III.
    Journal of molecular biology, 1998, Oct-02, Volume: 282, Issue:4

    Topics: Amino Acid Sequence; Animals; Blotting, Southern; Carbon-Oxygen Lyases; Cloning, Molecular; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA Glycosylases; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Exons; Expressed Sequence Tags; Humans; Introns; Mice; Mice, Inbred BALB C; Molecular Sequence Data; N-Glycosyl Hydrolases; Open Reading Frames; Physical Chromosome Mapping; Recombinant Fusion Proteins; Repressor Proteins; Response Elements; RNA, Messenger; Sequence Homology, Amino Acid; Thymine; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Urea

1998
Excision of products of oxidative DNA base damage by human NTH1 protein.
    Biochemistry, 1999, Jan-05, Volume: 38, Issue:1

    Topics: Barbiturates; Cytosine; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; Kinetics; Oxidation-Reduction; Substrate Specificity; Thymine; Uracil

1999
Excision of 5,6-dihydroxy-5,6-dihydrothymine, 5,6-dihydrothymine, and 5-hydroxycytosine from defined sequence oligonucleotides by Escherichia coli endonuclease III and Fpg proteins: kinetic and mechanistic aspects.
    Biochemistry, 1999, Mar-16, Volume: 38, Issue:11

    Topics: Cytosine; Deoxyribonuclease (Pyrimidine Dimer); DNA Repair; DNA-Formamidopyrimidine Glycosylase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Gas Chromatography-Mass Spectrometry; Kinetics; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Thymine

1999
The Saccharomyces cerevisiae homologues of endonuclease III from Escherichia coli, Ntg1 and Ntg2, are both required for efficient repair of spontaneous and induced oxidative DNA damage in yeast.
    Molecular and cellular biology, 1999, Volume: 19, Issue:5

    Topics: Amino Acid Sequence; Cytosine; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Fungal; Gene Targeting; Genes, Fungal; Helix-Loop-Helix Motifs; Hydrogen Peroxide; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; N-Glycosyl Hydrolases; Oxidative Stress; Pyrimidines; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Substrate Specificity; Thymine; Ultraviolet Rays

1999
Transcription dependence and the roles of two excision repair pathways for UV damage in fission yeast Schizosaccharomyces pombe.
    The Journal of biological chemistry, 1999, Sep-17, Volume: 274, Issue:38

    Topics: Cell Cycle Proteins; Cloning, Molecular; DNA Damage; DNA Repair; DNA, Fungal; Fungal Proteins; Molecular Sequence Data; Open Reading Frames; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Thymine; Transcription, Genetic; Ultraviolet Rays

1999
Dietary supplement of G-rutin reduces oxidative damage in the rodent model.
    Journal of agricultural and food chemistry, 1999, Volume: 47, Issue:3

    Topics: Animals; Antioxidants; Body Weight; Dietary Supplements; DNA Damage; Energy Intake; Lipid Peroxidation; Liver; Male; Proteins; Rats; Rats, Sprague-Dawley; Rutin; Thymine; Trisaccharides; Vitamins

1999
Double-base lesions are produced in DNA by free radicals.
    Archives of biochemistry and biophysics, 2000, Mar-01, Volume: 375, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Damage; Dose-Response Relationship, Radiation; Formamides; Free Radicals; Guanine; Pyrimidine Nucleosides; Single-Strand Specific DNA and RNA Endonucleases; Spectrometry, Mass, Fast Atom Bombardment; Thymine; Thymus Gland; X-Rays

2000
Single nucleotide patch base excision repair is the major pathway for removal of thymine glycol from DNA in human cell extracts.
    The Journal of biological chemistry, 2000, Apr-21, Volume: 275, Issue:16

    Topics: Base Sequence; Cell Line; DNA; DNA Repair; Fibroblasts; Humans; Molecular Sequence Data; Mutagenesis; Restriction Mapping; Thymine; Xeroderma Pigmentosum

2000
Purification and characterization of a novel DNA repair enzyme from the extremely radioresistant bacterium Rubrobacter radiotolerans.
    Journal of radiation research, 2000, Volume: 41, Issue:1

    Topics: Apurinic Acid; Arthrobacter; Bacterial Proteins; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Ligases; DNA Repair; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Endodeoxyribonucleases; Endonucleases; Escherichia coli; Escherichia coli Proteins; Radiation Tolerance; Radon; Substrate Specificity; Thymine; Urea; Water Microbiology

2000
Comparison of substrate specificities of Escherichia coli endonuclease III and its mouse homologue (mNTH1) using defined oligonucleotide substrates.
    Biochemistry, 2000, Sep-19, Volume: 39, Issue:37

    Topics: Animals; Base Pairing; Borohydrides; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; Endodeoxyribonucleases; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Mice; Oligonucleotides; Oligopeptides; Schiff Bases; Sequence Homology, Amino Acid; Stereoisomerism; Substrate Specificity; Thymine; Uracil; Urea

2000
Measuring DNA damage using capillary electrophoresis with laser-induced fluorescence detection.
    Methods (San Diego, Calif.), 2000, Volume: 22, Issue:2

    Topics: Animals; Bromodeoxyuridine; DNA Damage; Electrophoresis, Capillary; Fluorescent Dyes; Humans; Immunoassay; Immunoglobulin G; Lasers; Mice; Microscopy, Fluorescence; Radiation, Ionizing; Thymine; Time Factors

2000
Repair of clustered DNA damage caused by high LET radiation in human fibroblasts.
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 1998, Volume: 14 Suppl 1

    Topics: Cells, Cultured; DNA; DNA Damage; DNA Fragmentation; DNA Repair; DNA, Single-Stranded; Dose-Response Relationship, Radiation; Fibroblasts; Heavy Ions; Humans; Linear Energy Transfer; Nucleic Acid Hybridization; Particle Accelerators; Radiobiology; Skin; Thymine; X-Rays

1998
Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II.
    The Journal of biological chemistry, 2001, Nov-30, Volume: 276, Issue:48

    Topics: Animals; Base Sequence; Chromatography, High Pressure Liquid; DNA; DNA-Directed RNA Polymerases; DNA, Circular; Liver; Oligonucleotides; Oxidative Stress; Phosphorylation; Rats; RNA; RNA Polymerase II; Thymine; Time Factors; Transcription, Genetic; Viral Proteins

2001
Evaluation of phosphodiesterase I-based protocols for the detection of multiply damaged sites in DNA: the detection of abasic, oxidative and alkylative tandem damage in DNA oligonucleotides.
    Nucleic acids research, 2001, Oct-15, Volume: 29, Issue:20

    Topics: Alkylation; Chromatography, High Pressure Liquid; DNA Damage; Furans; Oligodeoxyribonucleotides; Organophosphates; Oxidation-Reduction; Phosphodiesterase I; Phosphoric Diester Hydrolases; Spectrometry, Mass, Electrospray Ionization; Thymine

2001
Synthesis and thermodynamic studies of oligonucleotides containing the two isomers of thymine glycol.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2001, Oct-15, Volume: 7, Issue:20

    Topics: Amides; DNA Damage; Drug Stability; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Oligonucleotides; Phosphoric Acids; Stereoisomerism; Temperature; Thermodynamics; Thymine

2001
Determination of active site residues in Escherichia coli endonuclease VIII.
    The Journal of biological chemistry, 2002, Jan-25, Volume: 277, Issue:4

    Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Deoxyribonuclease (Pyrimidine Dimer); DNA Primers; Dose-Response Relationship, Drug; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Kinetics; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxygen; Plasmids; Proline; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Thymine; Uracil

2002
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells.
    Nucleic acids research, 2002, Feb-01, Volume: 30, Issue:3

    Topics: Adenosine Triphosphatases; Amino Acid Motifs; Amino Acid Sequence; Apoptosis; Cell Extracts; Cell Line; Cell Survival; Cockayne Syndrome; Cytosine; DNA Damage; DNA Helicases; DNA Repair; DNA Repair Enzymes; Fibroblasts; Gene Expression Profiling; Genetic Complementation Test; Guanine; Humans; Hydrogen Peroxide; Mutation; Oligonucleotide Array Sequence Analysis; Poly-ADP-Ribose Binding Proteins; Protein Structure, Tertiary; Radiation Tolerance; RNA; Thymine; Ultraviolet Rays

2002
Translesion synthesis by human DNA polymerase eta across thymine glycol lesions.
    Biochemistry, 2002, May-14, Volume: 41, Issue:19

    Topics: Base Sequence; DNA; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Humans; In Vitro Techniques; Kinetics; Pyrimidine Dimers; Recombinant Proteins; Substrate Specificity; Thymine

2002
HPLC isolation and mass spectrometric characterization of two isomers of thymine glycols in oligodeoxynucleotides.
    Chemical research in toxicology, 2002, Volume: 15, Issue:5

    Topics: Chromatography, High Pressure Liquid; Nucleotides; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Thymine

2002
Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols.
    The EMBO journal, 2002, Jul-01, Volume: 21, Issue:13

    Topics: Alleles; Animals; Cell Nucleus; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Repair; DNA, Mitochondrial; Endodeoxyribonucleases; Escherichia coli Proteins; Female; Gene Targeting; Liver; Male; Mice; Mice, Knockout; Mitochondria, Liver; Mitochondrial Proteins; Oxidative Stress; Phenotype; Thymine

2002
Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decay.
    Journal of inorganic biochemistry, 2002, Jul-25, Volume: 91, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Alpha Particles; Animals; Ascorbic Acid; Catalase; Cattle; Deoxyguanosine; DNA; DNA Damage; Free Radical Scavengers; Humans; Hydrogen Peroxide; Iron; Nickel; Oxidants; Oxidation-Reduction; Radiation Injuries; Superoxide Dismutase; Thymine; Uranium

2002
Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides.
    The Journal of biological chemistry, 2002, Oct-04, Volume: 277, Issue:40

    Topics: Adenine; Base Sequence; DNA; DNA Damage; DNA Primers; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Humans; Nucleic Acid Conformation; Proteins; Substrate Specificity; Templates, Genetic; Thymine

2002
Global genome removal of thymine glycol in Escherichia coli requires endonuclease III but the persistence of processed repair intermediates rather than thymine glycol correlates with cellular sensitivity to high doses of hydrogen peroxide.
    Nucleic acids research, 2002, Nov-01, Volume: 30, Issue:21

    Topics: Cell Death; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Genome, Bacterial; Hydrogen Peroxide; Kinetics; Temperature; Thymine

2002
Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol.
    Genes & development, 2003, Jan-01, Volume: 17, Issue:1

    Topics: Base Pairing; DNA Damage; DNA Polymerase III; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; DNA, Fungal; Free Radicals; Fungal Proteins; Kinetics; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thymine

2003
Mode of inhibition of short-patch base excision repair by thymine glycol within clustered DNA lesions.
    The Journal of biological chemistry, 2003, Mar-14, Volume: 278, Issue:11

    Topics: Carbon-Oxygen Lyases; Chromatography, High Pressure Liquid; DNA; DNA Damage; DNA Polymerase beta; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Dose-Response Relationship, Drug; HeLa Cells; Humans; Oligonucleotides; Osmium Tetroxide; Ribosemonophosphates; Thymine; Time Factors

2003
Endonuclease IV enhances base excision repair of endonuclease III from Methanobacterium thermoautotrophicum.
    DNA repair, 2003, May-13, Volume: 2, Issue:5

    Topics: Amino Acid Sequence; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Guanine; Methanobacterium; Molecular Sequence Data; Oligonucleotides; Oxygen; Protein Binding; Recombinant Proteins; Sequence Homology, Amino Acid; Sodium Chloride; Thymine

2003
Oxidative DNA damage following exposure to dimethylarsinous iodide: the formation of cis-thymine glycol.
    Toxicology letters, 2003, Jul-20, Volume: 143, Issue:2

    Topics: Cacodylic Acid; Catalase; DNA Damage; Gas Chromatography-Mass Spectrometry; Molecular Structure; Oxidation-Reduction; Superoxide Dismutase; Thymine

2003
Synthesis of a thymine glycol building block and its incorporation into oligonucleotides.
    Nucleic acids symposium series, 2000, Issue:44

    Topics: Base Sequence; Chromatography, High Pressure Liquid; DNA Damage; Methods; Molecular Structure; Oligodeoxyribonucleotides; Osmium Tetroxide; Oxidation-Reduction; Thymine

2000
Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.
    Nucleic acids research, 2003, Sep-15, Volume: 31, Issue:18

    Topics: 5-Methylcytosine; Base Pair Mismatch; Deamination; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Guanine; Humans; Models, Genetic; Mutation; Oligonucleotides; Recombinant Proteins; Substrate Specificity; Thymine; Thymine DNA Glycosylase

2003
Stereoselective excision of thymine glycol from oxidatively damaged DNA.
    Nucleic acids research, 2004, Volume: 32, Issue:1

    Topics: Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Escherichia coli Proteins; Kinetics; N-Glycosyl Hydrolases; Oligonucleotides; Oxidation-Reduction; Oxidative Stress; Saccharomyces cerevisiae Proteins; Stereoisomerism; Substrate Specificity; Thymine

2004
Single-stranded breaks in DNA but not oxidative DNA base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts.
    The Journal of biological chemistry, 2004, Apr-30, Volume: 279, Issue:18

    Topics: Cell Extracts; Cell Nucleus; Cytosine; Deoxyribonucleosides; DNA Damage; DNA Repair; Guanine; HeLa Cells; Humans; Oxidation-Reduction; Pyrimidine Dimers; RNA Polymerase II; Templates, Genetic; Thymine; Transcription, Genetic

2004
Stereoselective excision of thymine glycol lesions by mammalian cell extracts.
    DNA repair, 2004, Mar-04, Volume: 3, Issue:3

    Topics: Animals; Cell Extracts; Cell Nucleus; Cross-Linking Reagents; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; Electrophoresis, Polyacrylamide Gel; Kinetics; Mice; Oligonucleotides; Schiff Bases; Stereoisomerism; Thymine; Tumor Cells, Cultured

2004
The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicity and tumorigenesis.
    Toxicology and applied pharmacology, 2004, Aug-01, Volume: 198, Issue:3

    Topics: Animals; Cacodylic Acid; Carcinogens; Herbicides; Mice; Mice, Inbred ICR; Mutagens; Oxidative Stress; Thymine

2004
Independent generation of the 5-hydroxy-5,6-dihydrothymidin-6-yl radical and its reactivity in dinucleoside monophosphates.
    Journal of the American Chemical Society, 2004, Oct-20, Volume: 126, Issue:41

    Topics: Dinucleoside Phosphates; DNA; Free Radicals; Oxygen; Photochemistry; Stereoisomerism; Thymidine; Thymine

2004
High-efficiency bypass of DNA damage by human DNA polymerase Q.
    The EMBO journal, 2004, Nov-10, Volume: 23, Issue:22

    Topics: Amino Acid Motifs; Amino Acid Sequence; Conserved Sequence; DNA Damage; DNA Polymerase theta; DNA-Directed DNA Polymerase; Humans; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Pyrimidine Dimers; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Templates, Genetic; Thymine

2004
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.
    DNA repair, 2005, Jan-02, Volume: 4, Issue:1

    Topics: Cloning, Molecular; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; DNA, Complementary; Escherichia coli; Humans; Hydrogen Peroxide; Mutation; Oligonucleotides; Pentoxyl; Thymine; Uracil

2005
Base excision repair by hNTH1 and hOGG1: a two edged sword in the processing of DNA damage in gamma-irradiated human cells.
    DNA repair, 2006, Jan-05, Volume: 5, Issue:1

    Topics: B-Lymphocytes; Cells, Cultured; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Glycosylases; DNA Repair; Down-Regulation; Gamma Rays; Gene Silencing; Humans; Hydrogen Peroxide; Thymine

2006
Host cell reactivation of plasmids containing oxidative DNA lesions is defective in Cockayne syndrome but normal in UV-sensitive syndrome fibroblasts.
    DNA repair, 2006, Jan-05, Volume: 5, Issue:1

    Topics: beta-Galactosidase; Cell Survival; Cells, Cultured; Cockayne Syndrome; DNA Damage; DNA Repair; DNA, Single-Stranded; Fibroblasts; Humans; Hydrogen Peroxide; Oxidative Stress; Plasmids; Syndrome; Thymine; Transfection; Ultraviolet Rays

2006
Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA.
    Nucleic acids research, 2006, Volume: 34, Issue:1

    Topics: Anti-Bacterial Agents; Binding Sites; Circular Dichroism; Distamycins; DNA; DNA Damage; Hydroxylation; Imidazoles; Isomerism; Oligodeoxyribonucleotides; Solvents; Surface Plasmon Resonance; Thymidine; Thymine

2006
Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization.
    DNA repair, 2006, Apr-08, Volume: 5, Issue:4

    Topics: Base Pairing; Catalysis; Deoxyribonuclease (Pyrimidine Dimer); Deoxyribose; DNA Damage; DNA Glycosylases; DNA Repair; Escherichia coli Proteins; Humans; Isomerism; Kinetics; Oligonucleotides; Purines; Substrate Specificity; Thymine

2006
A novel approach to DNA damage assessments: measurement of the thymine glycol lesion.
    Radiation research, 2006, Volume: 165, Issue:4

    Topics: Animals; Chromatography, Liquid; Dinucleoside Phosphates; DNA; DNA Damage; Dose-Response Relationship, Radiation; Fibroblasts; Mass Spectrometry; Mice; Mice, Inbred C3H; Mutagenicity Tests; Radiation Dosage; Thymine

2006
Singlet oxygen-induced DNA damage.
    Radiation research, 2006, Volume: 165, Issue:4

    Topics: Animals; Chromatography, Liquid; Dinucleoside Phosphates; DNA; DNA Damage; Dose-Response Relationship, Radiation; HeLa Cells; Humans; Mass Spectrometry; Mutagenicity Tests; Radiation Dosage; Singlet Oxygen; Thymine

2006
Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.
    The Journal of biological chemistry, 2006, Aug-18, Volume: 281, Issue:33

    Topics: Amino Acid Sequence; DNA Damage; DNA Polymerase I; DNA Polymerase theta; DNA Replication; DNA-Directed DNA Polymerase; Humans; Molecular Sequence Data; Protein Processing, Post-Translational; Recombinant Proteins; Templates, Genetic; Thymine

2006
Photoinduced reductive repair of thymine glycol: implications for excess electron transfer through DNA containing modified bases.
    Journal of the American Chemical Society, 2006, Aug-23, Volume: 128, Issue:33

    Topics: DNA; DNA Damage; Electron Transport; Flavin-Adenine Dinucleotide; Lasers; Light; Oligonucleotides; Oxidation-Reduction; Phenothiazines; Photolysis; Thymine

2006
RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors.
    The EMBO journal, 2006, Nov-29, Volume: 25, Issue:23

    Topics: DNA Damage; DNA Helicases; DNA Repair; DNA Repair Enzymes; Elongin; Guanine; HeLa Cells; Humans; Oxidative Stress; Poly-ADP-Ribose Binding Proteins; RNA Polymerase II; Thymine; Transcription Factors; Transcription Factors, TFII; Transcription, Genetic; Transcriptional Elongation Factors; Uracil

2006
Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions.
    Nucleic acids symposium series (2004), 2004, Issue:48

    Topics: DNA Damage; DNA Glycosylases; HeLa Cells; Humans; Oxidation-Reduction; Pyrimidines; Solutions; Stereoisomerism; Substrate Specificity; Thymine

2004
Characterization of the binding of distamycin A to damaged DNA: a comparison with the DNA recognition of the human DDB protein.
    Nucleic acids symposium series (2004), 2006, Issue:50

    Topics: Binding Sites; Distamycins; DNA; DNA Damage; DNA-Binding Proteins; Fluorescence Resonance Energy Transfer; Humans; Nucleic Acid Conformation; Protein Binding; Pyrimidine Dimers; Surface Plasmon Resonance; Thymine

2006
RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.
    DNA repair, 2007, Jun-01, Volume: 6, Issue:6

    Topics: Adenine; Base Sequence; DNA Damage; DNA Repair; Guanine; HeLa Cells; Humans; Models, Chemical; Models, Genetic; Molecular Sequence Data; Oxygen; RNA Polymerase II; Thymine; Transcription, Genetic; Transcriptional Elongation Factors

2007
Cylindrical projection of electrostatic potential and image analysis tools for damaged DNA: the substitution of thymine with thymine glycol.
    The journal of physical chemistry. B, 2008, Feb-21, Volume: 112, Issue:7

    Topics: Diagnostic Imaging; DNA Damage; Models, Molecular; Nucleic Acid Conformation; Oligonucleotides; Quantum Theory; Static Electricity; Thymine

2008
A novel monofunctional DNA glycosylase activity against thymine glycol in mouse cell nuclei.
    Journal of radiation research, 2008, Volume: 49, Issue:3

    Topics: Animals; Blotting, Western; Cell Nucleus; Chromatography; DNA Glycosylases; DNA Repair; Fluorometry; Mice; Mice, Inbred DBA; Reverse Transcriptase Polymerase Chain Reaction; Thymine

2008
Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts.
    Nucleic acids research, 2008, Volume: 36, Issue:9

    Topics: Base Pair Mismatch; Cell Extracts; Cell Nucleus; DNA Breaks, Double-Stranded; DNA Polymerase beta; DNA Repair; Guanine; HeLa Cells; Humans; Recombinant Fusion Proteins; Thymine

2008
Interconversion of the cis-5R,6S- and trans-5R,6R-thymine glycol lesions in duplex DNA.
    Journal of the American Chemical Society, 2008, Sep-03, Volume: 130, Issue:35

    Topics: Carbohydrate Conformation; Deoxyribose; DNA; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Oligonucleotides; Thermodynamics; Thymine

2008
Altered expression of the human base excision repair gene NTH1 in gastric cancer.
    Carcinogenesis, 2009, Volume: 30, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Case-Control Studies; Deoxyribonuclease (Pyrimidine Dimer); DNA, Neoplasm; Down-Regulation; Female; Gastric Mucosa; Genotype; Humans; Immunoenzyme Techniques; Intestinal Neoplasms; Luciferases; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Thymine; Young Adult

2009
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.
    The Journal of biological chemistry, 2009, Jul-03, Volume: 284, Issue:27

    Topics: Basic-Leucine Zipper Transcription Factors; Breast Neoplasms; DNA; DNA Adducts; DNA Damage; DNA Helicases; Enzyme Activation; Fanconi Anemia; Fanconi Anemia Complementation Group Proteins; Female; Guanine; Humans; Oxidative Stress; Replication Protein A; Substrate Specificity; Thymine

2009
Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic.
    Nucleic acids research, 2009, Volume: 37, Issue:13

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Deoxyguanosine; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Damage; DNA Repair; Escherichia coli; Mutagenesis; Thymine; Transformation, Bacterial; Uracil

2009
Theoretical studies on the thermodynamics and kinetics of the N-glycosidic bond cleavage in deoxythymidine glycol.
    The journal of physical chemistry. B, 2009, Jul-30, Volume: 113, Issue:30

    Topics: Crystallography, X-Ray; Glycosides; Hydrolysis; Kinetics; Models, Molecular; Molecular Conformation; Solvents; Thermodynamics; Thymine; Water

2009
The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with deoxyguanosine in DNA.
    Biochemistry, 2009, Oct-20, Volume: 48, Issue:41

    Topics: 5-Methylcytosine; Base Pairing; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Oligodeoxyribonucleotides; Protons; Thymine

2009
Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site.
    Nucleic acids research, 2010, Volume: 38, Issue:2

    Topics: Base Pairing; Base Sequence; Binding Sites; DNA; DNA Damage; DNA Repair Enzymes; DNA-Binding Proteins; Endodeoxyribonucleases; Escherichia coli Proteins; Humans; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protons; Stereoisomerism; Thymine; Xeroderma Pigmentosum Group A Protein

2010
Efficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cattle; Copper; Deoxyguanosine; DNA; DNA Damage; DNA Polymerase beta; Escherichia coli; Gamma Rays; Hydrogen Peroxide; Mutation; Thymine

2010
DNA polymerases beta and lambda bypass thymine glycol in gapped DNA structures.
    Biochemistry, 2010, Jun-08, Volume: 49, Issue:22

    Topics: Base Pairing; Catalysis; DNA Damage; DNA Polymerase beta; DNA Repair; DNA Replication; Humans; Multigene Family; Proliferating Cell Nuclear Antigen; Replication Protein A; Substrate Specificity; Templates, Genetic; Thymine

2010
Products of thymine oxygenation by a non-heme oxygenation model, Fe(II)(MeCN)6(2+)-Ac2O-H2O2, and the transition state model between oxoiron and thymine.
    Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:6

    Topics: DNA Damage; Iron Compounds; Models, Biological; Oxidation-Reduction; Thymine

2010
Error-free replicative bypass of thymine glycol by the combined action of DNA polymerases kappa and zeta in human cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Aug-10, Volume: 107, Issue:32

    Topics: DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Humans; Thymine

2010
A nuclear family A DNA polymerase from Entamoeba histolytica bypasses thymine glycol.
    PLoS neglected tropical diseases, 2010, Aug-10, Volume: 4, Issue:8

    Topics: Cell Nucleus; DNA Polymerase III; Entamoeba histolytica; Models, Molecular; Phylogeny; Protein Structure, Tertiary; Protozoan Proteins; Recombinant Proteins; Sequence Homology; Thymine

2010
Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.
    Journal of molecular biology, 2011, Jan-21, Volume: 405, Issue:3

    Topics: Amino Acid Sequence; Animals; Base Sequence; DNA Damage; DNA Polymerase theta; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Genes, pol; Humans; Mice; Molecular Sequence Data; Protein Structure, Tertiary; Thymine

2011
A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex.
    Journal of molecular biology, 2011, Sep-09, Volume: 412, Issue:1

    Topics: DNA Replication; DNA-Directed DNA Polymerase; Molecular Sequence Data; Protein Binding; Protein Structure, Secondary; Thymine; Viral Proteins

2011
New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.
    PloS one, 2011, Volume: 6, Issue:7

    Topics: Base Sequence; DNA; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; HeLa Cells; Humans; Hydantoins; Kinetics; Oligodeoxyribonucleotides; Oxidation-Reduction; Pyrimidines; Thymine; Urea

2011
Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA.
    The Journal of biological chemistry, 2012, Feb-03, Volume: 287, Issue:6

    Topics: Catalytic Domain; Crystallography, X-Ray; DNA; DNA Glycosylases; Humans; Mimiviridae; Oxidation-Reduction; Thymine; Uracil

2012
The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability.
    Nucleic acids research, 2012, Volume: 40, Issue:14

    Topics: Cell Line; DNA; DNA Damage; Genomic Instability; Guanine; HeLa Cells; Humans; Protein Interaction Domains and Motifs; RecQ Helicases; S Phase; Sister Chromatid Exchange; Thymine

2012
Structural and functional properties of CiNTH, an endonuclease III homologue of the ascidian Ciona intestinalis: critical role of N-terminal region.
    Genes & genetic systems, 2012, Volume: 87, Issue:2

    Topics: Amino Acid Sequence; Animals; Ciona intestinalis; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Glycosylases; DNA Repair; Escherichia coli; Gene Expression Regulation; Guanine; Humans; Hydrogen Peroxide; Molecular Sequence Data; Reactive Oxygen Species; Sequence Alignment; Thymine; Uracil

2012
Highly mutagenic exocyclic DNA adducts are substrates for the human nucleotide incision repair pathway.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Adenine; Biocatalysis; Cell Extracts; Cell-Free System; Cytosine; DNA Adducts; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; HeLa Cells; Humans; Kinetics; Mutagens; Oligonucleotides; Oxidation-Reduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Thymine; Time Factors

2012
Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases.
    DNA repair, 2013, Jun-01, Volume: 12, Issue:6

    Topics: DNA Adducts; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Ligases; DNA Repair Enzymes; DNA-Activated Protein Kinase; DNA-Binding Proteins; Endonucleases; Glycolates; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Nuclear Proteins; Recombinational DNA Repair; Thymine

2013
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions.
    DNA repair, 2013, Volume: 12, Issue:7

    Topics: DNA; DNA Adducts; DNA Damage; DNA Repair; Exodeoxyribonucleases; Humans; Nucleic Acid Conformation; Oxidation-Reduction; Reactive Oxygen Species; RecQ Helicases; Rothmund-Thomson Syndrome; Telomere; Telomeric Repeat Binding Protein 2; Thymine; Werner Syndrome Helicase

2013
Contribution of DNA unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes.
    DNA repair, 2013, Volume: 12, Issue:11

    Topics: Chromatin Assembly and Disassembly; DNA Damage; DNA Glycosylases; DNA Repair; DNA, Ribosomal; Histones; Humans; Kinetics; Nucleosomes; Oxidative Stress; Thymine

2013
Stimulation of N--glycoside transfer in deoxythymidine glycol: mechanism of the initial step in base excision repair.
    Journal of molecular modeling, 2014, Volume: 20, Issue:3

    Topics: Computer Simulation; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Repair; Glycosides; Models, Chemical; Models, Molecular; Molecular Structure; Thymidine; Thymine

2014
A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.
    The Journal of biological chemistry, 2014, May-09, Volume: 289, Issue:19

    Topics: Cell Line; DNA Polymerase theta; DNA Replication; DNA-Directed DNA Polymerase; Fibroblasts; Humans; Oxidation-Reduction; Protein Structure, Tertiary; Thymine

2014
Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice.
    Neurobiology of aging, 2015, Volume: 36, Issue:7

    Topics: Animals; Disease Models, Animal; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Endonucleases; Gene Expression; Humans; Hypoxia, Brain; Loss of Heterozygosity; Male; Mice; Nucleotides; Risk Factors; Stroke; Thymine; X-ray Repair Cross Complementing Protein 1

2015
Impact of thymine glycol damage on DNA duplex energetics: Correlations with lesion-induced biochemical and structural consequences.
    Biopolymers, 2015, Volume: 103, Issue:9

    Topics: Calorimetry, Differential Scanning; Circular Dichroism; DNA; DNA Damage; Nucleic Acid Conformation; Thermodynamics; Thymine

2015
Nonhomologous end joining of complex DNA double-strand breaks with proximal thymine glycol and interplay with base excision repair.
    DNA repair, 2016, Volume: 41

    Topics: DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Repair; HCT116 Cells; Humans; Thymine

2016
Expression and the Peculiar Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA Glycosylase.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Amino Acid Sequence; Animals; Cell Line; Chagas Disease; DNA Damage; DNA Glycosylases; DNA Repair; Gene Expression Regulation; Humans; Models, Molecular; Oxidative Stress; Protein Conformation; Rats; Sequence Alignment; Thymine; Trypanosoma cruzi

2016
Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 07-12, Volume: 113, Issue:28

    Topics: Computer Simulation; Crystallography; DNA; DNA Glycosylases; DNA Repair; Escherichia coli; Furans; Humans; Models, Chemical; Thymine

2016
A new understanding towards the reactivity of DNA peroxy radicals.
    Physical chemistry chemical physics : PCCP, 2016, Sep-14, Volume: 18, Issue:34

    Topics: DNA; Free Radicals; Gases; Oxidation-Reduction; Thermodynamics; Thymine; Water

2016
Enhanced sensitivity of Neil1
    DNA repair, 2016, Volume: 48

    Topics: Animals; Cytokines; DNA Damage; DNA Glycosylases; DNA Repair; Gene Expression Profiling; Gene Expression Regulation; Guanine; Inflammation; Mice; Mice, Knockout; Neutrophil Infiltration; Oxidative Stress; Pyrimidines; Reactive Oxygen Species; Skin; Thymine; Ultraviolet Rays; Uracil

2016
Molecular mechanisms by which oxidative DNA damage promotes telomerase activity.
    Nucleic acids research, 2017, Nov-16, Volume: 45, Issue:20

    Topics: Base Sequence; DNA; DNA Damage; DNA, Single-Stranded; G-Quadruplexes; Guanine; HEK293 Cells; Humans; Oxidative Stress; Protein Binding; Shelterin Complex; Telomerase; Telomere; Telomere Homeostasis; Telomere-Binding Proteins; Thymine

2017
Development of a Cell-Based Assay for Measuring Base Excision Repair Responses.
    Scientific reports, 2017, 10-11, Volume: 7, Issue:1

    Topics: Base Sequence; Biological Assay; DNA; DNA Repair; HEK293 Cells; HeLa Cells; Humans; Nucleic Acid Conformation; Oligonucleotides; Thymine; Time Factors

2017
The active site residues Gln55 and Arg73 play a key role in DNA damage bypass by S. cerevisiae Pol η.
    Scientific reports, 2018, 07-09, Volume: 8, Issue:1

    Topics: Arginine; Catalytic Domain; DNA Damage; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Glycine; Guanine; Mutagenesis, Site-Directed; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thymine

2018
Complex interplay of lesion-specific DNA repair enzyme on bistranded clustered DNA damage harboring Tg:G mismatch in nucleosome core particles.
    Journal of biosciences, 2018, Volume: 43, Issue:4

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Cell Extracts; Deoxyguanosine; Deoxyribonuclease (Pyrimidine Dimer); DNA Breaks, Double-Stranded; DNA Damage; DNA Glycosylases; DNA Mismatch Repair; DNA Repair; HeLa Cells; Humans; Nucleosomes; Oxidative Stress; Radiation, Ionizing; Thymine

2018
The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks.
    Genes, 2019, 04-23, Volume: 10, Issue:4

    Topics: Cell Cycle; DNA; DNA Glycosylases; DNA Replication; DNA, Single-Stranded; Humans; Models, Genetic; N-Glycosyl Hydrolases; Thymine; Uracil

2019
The remarkable UV light invulnerability of thymine GNA dinucleotides.
    Chemical communications (Cambridge, England), 2019, Oct-15, Volume: 55, Issue:83

    Topics: Nucleic Acid Conformation; Nucleotides; Thymine; Ultraviolet Rays

2019
Mutagenic Effects of a 2-Deoxyribonolactone-Thymine Glycol Tandem DNA Lesion in Human Cells.
    Biochemistry, 2020, 02-04, Volume: 59, Issue:4

    Topics: DNA; DNA Damage; DNA Polymerase iota; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; HEK293 Cells; Humans; Mutagenesis; Mutagens; Nucleotides; Sugar Acids; Thymine

2020
Plant organellar DNA polymerases bypass thymine glycol using two conserved lysine residues.
    The Biochemical journal, 2020, 03-13, Volume: 477, Issue:5

    Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Conserved Sequence; DNA-Directed DNA Polymerase; Lysine; Organelles; Thymine

2020
Mutational analysis of Thermococcus kodakarensis Endonuclease III reveals the roles of evolutionarily conserved residues.
    DNA repair, 2020, Volume: 90

    Topics: Amino Acid Sequence; Archaeal Proteins; DNA Damage; DNA Glycosylases; DNA Repair; DNA, Archaeal; Evolution, Molecular; Kinetics; Protein Structural Elements; Sequence Analysis, Protein; Substrate Specificity; Thermococcus; Thymine

2020
The eukaryotic replisome tolerates leading-strand base damage by replicase switching.
    The EMBO journal, 2021, 03-01, Volume: 40, Issue:5

    Topics: DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thymine

2021
RNA Editing of the Human DNA Glycosylase NEIL1 Alters Its Removal of 5-Hydroxyuracil Lesions in DNA.
    Biochemistry, 2021, 05-18, Volume: 60, Issue:19

    Topics: DNA; DNA Glycosylases; DNA Repair; DNA, Single-Stranded; Humans; Oxidation-Reduction; RNA Editing; Thymine; Uracil

2021
Study of optical absorption cross-section spectra and high-order harmonic generation of thymine, thymine glycol, and thymine dimer molecules.
    Journal of molecular modeling, 2022, Nov-28, Volume: 28, Issue:12

    Topics: Density Functional Theory; Electrons; Pyrimidine Dimers; Thymine

2022
Synthetic DNA binders for fluorescent sensing of thymine glycol-containing DNA duplexes and inhibition of endonuclease activity.
    Chemical communications (Cambridge, England), 2023, May-16, Volume: 59, Issue:40

    Topics: DNA; DNA Repair; Endonucleases; Thymine

2023