thymine and zidovudine

thymine has been researched along with zidovudine in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's8 (61.54)18.2507
2000's2 (15.38)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Anderson, KS; Chu, CK; Mathew, JS; Ray, AS; Schinazi, RF; Shi, J1
Andries, K; De Clercq, E; Debyser, Z; Pauwels, R1
Bull, CO; Landry, ML; Milstone, LM; Reuveni, H; Schwartz, PM1
Baba, M; De Clercq, E; Mori, S; Nitta, I; Sekiya, K; Takashima, H; Tanaka, H; Ubasawa, M; Umezu, K; Walker, RT1
Mitsuya, H1
Baba, M; Balzarini, J; De Clercq, E; Miyasaka, T; Nakashima, H; Pauwels, R; Perno, CF; Schols, D; Tanaka, H; Walker, RT1
Alvarez, R; Balzarini, J; Camarasa, MJ; De Clercq, E; Jimeno, ML; San-Félix, A; Velázquez, S1
Bader, JP; Boyer, PL; Buckheit, RW; Chu, SH; Fliakas-Boltz, V; Hughes, SH; Mayers, DL; Pan, BC; Weislow, O; Yeagy-Bargo, S1
Cretton, EM; Hitchcock, MJ; Kaul, S; Kidd, LB; McClure, HM; Sommadossi, JP; Zhou, Z1
Danel, K; el-Emam, AA; Larsen, E; Nielsen, C; Pedersen, EB; Vaaben, GB1
Agelis, G; Botić, T; Cencic, A; Dolinsek, J; Komiotis, D; Tsoukala, E1
Adhikary, A; Khanduri, D; Pottiboyina, V; Rice, CT; Sevilla, MD1
Burt, MB; Marta, RA; Martens, JK; Martens, SM; McMahon, TB; Ziegler, BE1

Reviews

1 review(s) available for thymine and zidovudine

ArticleYear
Specific HIV-1 reverse transcriptase inhibitors.
    Journal of enzyme inhibition, 1992, Volume: 6, Issue:1

    Topics: Antiviral Agents; Benzodiazepines; HIV Reverse Transcriptase; HIV-1; Imidazoles; Models, Genetic; Reverse Transcriptase Inhibitors; Thymine; Transcription, Genetic; Zidovudine

1992

Other Studies

12 other study(ies) available for thymine and zidovudine

ArticleYear
2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions.
    Bioorganic & medicinal chemistry letters, 2004, May-03, Volume: 14, Issue:9

    Topics: Acids; Animals; Cell Line; Dideoxynucleosides; Furans; Humans; Magnetic Resonance Spectroscopy

2004
Antiviral activity of 5-iodo-2'-deoxyuridine and related drugs in human keratinocytes infected in vitro with herpes simplex virus type 1.
    Skin pharmacology : the official journal of the Skin Pharmacology Society, 1991, Volume: 4, Issue:4

    Topics: Animals; Antiviral Agents; Bromodeoxyuridine; Drug Interactions; Guinea Pigs; Herpes Simplex; Humans; Idoxuridine; Keratinocytes; Simplexvirus; Thymidine; Thymidine Phosphorylase; Thymine; Zidovudine

1991
Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives.
    Molecular pharmacology, 1991, Volume: 39, Issue:6

    Topics: Antiviral Agents; HIV-1; Humans; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine; Zidovudine

1991
[Inhibitors of HIV-1 reverse transcriptase and protease as chemotherapeutics for AIDS].
    Nihon rinsho. Japanese journal of clinical medicine, 1991, Volume: 49, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Didanosine; HIV Protease Inhibitors; HIV Reverse Transcriptase; HIV-1; Humans; Reverse Transcriptase Inhibitors; Thymine; Zalcitabine; Zidovudine

1991
Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.
    Biochemical and biophysical research communications, 1989, Dec-29, Volume: 165, Issue:3

    Topics: Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Line; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; HIV Antigens; HIV-1; HIV-2; Lymphocytes; Macrophages; Thymine; Virus Replication; Zalcitabine; Zidovudine

1989
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.
    Journal of medicinal chemistry, 1995, May-12, Volume: 38, Issue:10

    Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Polymers; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Thymine; Uridine; Zidovudine

1995
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase.
    Virology, 1995, Jun-20, Volume: 210, Issue:1

    Topics: Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Mutagenesis, Site-Directed; Nevirapine; Pyridines; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine; Uracil; Zidovudine

1995
In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:9

    Topics: Aminoisobutyric Acids; Animals; Antiviral Agents; Biological Availability; Biotransformation; Chromatography, High Pressure Liquid; Feces; HIV; In Vitro Techniques; Injections, Intravenous; Injections, Subcutaneous; Liver; Macaca fascicularis; Macaca mulatta; Rats; Rats, Sprague-Dawley; Stavudine; Thymine; Zidovudine

1993
Synthesis of an AZT-HEPT hybrid and homologous AzddU derivatives.
    Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 1996, Volume: 50, Issue:5

    Topics: Antiviral Agents; Thymine; Zidovudine

1996
An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents.
    Bioorganic & medicinal chemistry, 2007, May-01, Volume: 15, Issue:9

    Topics: Antineoplastic Agents; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Intestines; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Rotavirus; Stereoisomerism; Structure-Activity Relationship; Thymine; Uracil; Xylose; Zidovudine

2007
Formation of aminyl radicals on electron attachment to AZT: abstraction from the sugar phosphate backbone versus one-electron oxidation of guanine.
    The journal of physical chemistry. B, 2010, Jul-22, Volume: 114, Issue:28

    Topics: Anti-HIV Agents; Electron Spin Resonance Spectroscopy; Electrons; Free Radicals; Guanine; Models, Theoretical; Oxidation-Reduction; Sugar Phosphates; Thymidine; Thymine; Zidovudine

2010
Structural investigation of protonated azidothymidine and protonated dimer.
    Journal of the American Society for Mass Spectrometry, 2014, Volume: 25, Issue:2

    Topics: Dimerization; Hydrogen Bonding; Models, Molecular; Protons; Spectrometry, Mass, Electrospray Ionization; Thymine; Vibration; Zidovudine

2014