thymine has been researched along with uracil in 1207 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 655 (54.27) | 18.7374 |
| 1990's | 93 (7.71) | 18.2507 |
| 2000's | 158 (13.09) | 29.6817 |
| 2010's | 231 (19.14) | 24.3611 |
| 2020's | 70 (5.80) | 2.80 |
| Authors | Studies |
|---|---|
| Hall, IH; Lee, KH; Wu, YS | 1 |
| Aryasomayajula, R; Bandi, PR; Jennepalli, S; Kura, RR; Musku, MR; Rondla, SR; Vedula, MS | 1 |
| Di Fate, V; Nelson, V; Shapiro, R; Welcher, M | 1 |
| Hayatsu, H | 1 |
| Castro, A; Guiffrida, AM; Ragusa, N; Ricceri, G | 1 |
| Chadha, MS; Choughuley, AS; Kazi, ZA; Subbaraman, AS | 1 |
| Brabec, V; Christian, SD; Dryhurst, G | 1 |
| Hradecna, Z; Jacob, HE; Kittler, L; Löber, G | 1 |
| Cohen, SS; I, J | 1 |
| Okazaki, T; Tamanoi, F | 1 |
| Abbott, MT; Hsu, CA; Shaffer, PM | 1 |
| Forsthoefel, PF; Williams, ML | 1 |
| Edwards, ES; Magill, CW; Magill, JM; Sabina, RL | 1 |
| Cadet, J; Teoule, R | 3 |
| Johnson, GA | 1 |
| Hoshi, A; Riesz, P; Rustgi, S | 1 |
| Riesz, P; Rustgi, S | 1 |
| Flossmann, W; Westhof, E; Zehner, H | 1 |
| Hilton, MG | 1 |
| McGhee, JD; von Hippel, PH | 1 |
| Voytek, P | 1 |
| Berglund, G; Greter, J; Lindstedt, S; Steen, G; Waldenström, J; Wass, U | 1 |
| Ihara, J; Patterson, LK; Redpath, JL | 1 |
| Al Chalabi, K; Gutteridge, WE | 1 |
| Jenkin, HM; Sandok, PL | 1 |
| Chelton, ET; Jones, AS; Walker, RT | 2 |
| Finn, C; Sadée, W; Schwandt, HJ | 1 |
| Griffith, LM; MacInnis, AJ; Page, CR | 1 |
| King, TJ; Raverty, WD; Thomson, RH | 1 |
| Hsiao, WL; Krooth, RS; Lam, GF | 1 |
| Sonoda, T; Tatibana, M | 1 |
| DiMenna, WS; Lamb, RG; Piantadosi, C | 1 |
| Isono, K; Suhadolnik, RJ | 1 |
| Alazard, R; Boquet, PL; Paoletti, C | 1 |
| Dyson, HJ; Upcroft, P; Wake, RG | 1 |
| Ianson, IK; Sukhodub, LF | 2 |
| Germain, MJ; Gore, SS; Kirss, TA; Pauly, JL; Schuller, MG; Zelcer, AA | 1 |
| Kumar, U; Sanyal, NK; Sinha, RP | 1 |
| McCloskey, JA; Puzo, G; Schram, KH | 1 |
| Hahn, BS; Wang, SY | 1 |
| Chittenden, GJ; Schwartz, AW | 1 |
| Christman, CL; McKee, JR; O'Brien, WD; Wang, SY | 1 |
| Burr, JG; Lee, YJ; Summers, WA | 1 |
| Dougherty, D; McGlynn, SP; Meeks, J; Wittel, K | 1 |
| Al-Obeidi, FA; Borazan, HN | 1 |
| Bekker, ML; Milstein, OA | 1 |
| Ianson, IK; Sukhodub, LF; Verkin, BI | 1 |
| Al-Obeidi, F; Borazan, HN | 1 |
| Taguchi, H; Wang, SY | 1 |
| Cech, D; Hein, L; Langen, P; Otto, A; von Janta-Lipinski, M; Wuttke, R | 1 |
| MacInnis, AJ; Page, CR | 1 |
| Varghese, AJ | 3 |
| Hom, ML; Loman, H | 1 |
| Yamamoto, O | 1 |
| Lhotská, M; Vondrejs, V | 1 |
| Moustacchi, E; Waters, R | 1 |
| Bhattacharjee, SB; Bhaumik, G | 2 |
| Byrd, DM; Prusoff, WH | 1 |
| Burr, JG; Lee, YS; Summers, WA | 1 |
| Kolosov, AI | 1 |
| Bensasson, R; Salet, C | 1 |
| Bulgakova, VG; Korolev, PN; Melikhova, EI; Polin, AN; Silaev, AB | 1 |
| Miller, V; Pacáková, V; Smolková, E | 1 |
| Danilov, VI; Shulga, SM | 1 |
| Rebek, J | 1 |
| Ebright, RH; Ebright, YW; Gunasekera, A | 1 |
| Nese, C; Schuchmann, MN; Von Sonntag, C; Yuan, Z | 1 |
| Arison, B; Darland, G; Kaplan, L | 1 |
| Abeling, NG; Driedijk, PC; Elzinga, A; van Gennip, AH | 1 |
| Bisaro, DM; Brough, CL; Ehrlich, M; Gardiner, WE; Inamdar, NM; Zhang, XY | 1 |
| Pu, WT; Struhl, K | 1 |
| el-Hajj, HH; Wang, L; Weiss, B | 1 |
| Mark, F; Rashid, R; Schuchmann, HP; von Sonntag, C | 2 |
| Herak, JN; Hüttermann, J | 1 |
| Chen, EC; Chen, ES; Ehdaie, S; Robinson, JM; Wentworth, WE; Wiley, JR | 1 |
| Seal, G; Sirover, MA; Tallarida, RJ | 1 |
| Camiña, F; Castro-Gago, M; Lojo, S; Rodríguez-Núñez, A; Rodríguez-Segade, S | 1 |
| Abeling, NG; Busch, S; Scholten, EG; Stroomer, LE; van Gennip, AH | 1 |
| Adolph, KJ; Fung, E; McLeod, DR; Morgan, K; Snyder, FF | 1 |
| Bruskov, VI; Galetich, IK; Poltev, VI; Shulyupina, NV; Sukhodub, LF; Teplitsky, AB | 1 |
| Joly, JM; Williams, WM | 1 |
| Chestnut, WG; Merrill, BM; Porter, DJ; Spector, T; Taylor, LC | 1 |
| Berger, R; Duran, M; Jakobs, C; Rovers, P; Smit, LM; Stellaard, F; van Vugt, JM | 1 |
| Zhang, CT; Zhang, R | 1 |
| Iwamoto, K; Lin, ML; Seno, M | 1 |
| Carlson, RM; Samanta, AK; Xue, WL | 1 |
| Görner, H | 1 |
| Buchanan, MV; Hettich, RL; Ho, CH | 1 |
| Danilov, VI; Tolokh, IS | 2 |
| Cheong, C; Clark, LB; Tinoco, I; Williams, AL | 1 |
| Gray, DM; Ratliff, RL; Steely, HT | 1 |
| Bystrova, MO; Ivin, BA; Korsakov, MV; Likhachev, AJ; Mironiuk, TA; Nefedov, VD; Sinotova, EN | 1 |
| Herrala, AM; Vilpo, JA | 1 |
| Ide, N; Itahara, T; Nishino, A | 1 |
| Abeling, NG; Bakker, HD; Elzinga-Zoetekouw, L; Scholten, LG; van Cruchten, A; van Gennip, AH | 1 |
| Okajima, K; Suchi, M; Wada, Y; Yamamoto, T | 1 |
| Bruskov, VI; Bushuev, VN; Okon, MS; Poltev, VI; Shulyupina, NV | 1 |
| Misra, TN; Sarkar, D | 1 |
| Ho, IK; Kimura, T; Tateoka, Y; Watanabe, K; Yamamoto, I | 2 |
| Bronk, JR; Hastewell, JG | 1 |
| Ahluwalia, JC; Bhat, R; Kishore, N | 1 |
| Kondo, T; Murali Krishna, C; Riesz, P | 1 |
| Rivera, VM; Sarai, A; Takeda, Y | 1 |
| Kiang, DT; Mirkin, BL; O'Dea, RF; Ramnaraine, ML; Stoeckeler, JS; Tuchman, M | 1 |
| Schuchmann, HP; von Sonntag, C | 1 |
| Schuchmann, HP; von Sonntag, C; Wagner, R | 1 |
| Basappa, SC; Murthy, VS; Vishwanath, P | 1 |
| Aiba, N; Kawazoe, Y; Okuhara, E; Wakizaka, A | 1 |
| Fujii, S; Fukushima, M; Shirasaka, T; Tatsumi, K | 1 |
| Kankaanpää, PU; Nykänen, PJ; Raunio, PV | 1 |
| Olivares, J; Verdys, M | 1 |
| Clark, W; Olson, WK; Srinivasan, AR; Torres, R | 1 |
| Ehrlich, KC; Ehrlich, M; Shenoy, S | 1 |
| Fujita, S; Nagata, Y | 1 |
| Deeble, DJ; von Sonntag, C | 1 |
| Ehrlich, M; Gehrke, CW; Kuo, KC; Norris, KF; Wang, RY | 1 |
| Patel, BN; West, TP | 1 |
| Hammond, MM; Jarroll, EL; Lindmark, DG | 1 |
| Bakkeren, JA; Braakhekke, JP; De Abreu, RA; Gabreëls, FJ; Renier, WO; Sengers, RC | 1 |
| Bronk, JR; Lister, N; Lynch, S | 1 |
| Franzus, MJ; Malcolm, GB; Pine, L | 1 |
| Meadows, J; Smith, RC | 1 |
| Bakkeren, JA; Braakhekke, J; De Abreu, RA; Gabreels, FJ; Maas, JM; Sengers, RC | 1 |
| O'Dea, RF; Ramnaraine, ML; Tuchman, M | 2 |
| Kunz, BA | 1 |
| Cadet, J; Cummings, A; Frenkel, K; Solomon, J; Steinberg, JJ; Teebor, GW | 1 |
| Beemer, FA; Berger, R; de Bree, PK; Duran, M; Penders, TJ; Stoker-de Vries, SA; van der Woude, JK; Wadman, SK; Weits-Binnerts, JJ | 2 |
| Berger, R; Hammond, J; James, C; Wilcken, B; Wise, G | 1 |
| Fujimoto, S; Mizota, C; Mizutani, N; Tamaki, N | 1 |
| Balzarini, J; Bricaud, H; De Clercq, E; Desgranges, C; Drouillet, F; Herdewijn, P; Razaka, G | 1 |
| Kollman, PA; Rao, SN | 1 |
| Cano, JP; Cross, DS; Diasio, RB; Gewirtz, DA; Goldman, ID; Sommadossi, JP | 1 |
| Dizdaroglu, M; Simic, MG | 1 |
| Collins, JM; Fine, RL; Jenkins, JF; Kinsella, TJ; Klecker, RW; Strong, JM | 1 |
| Gutiérrez, C; Hernández, P; Maldonado, A | 1 |
| Ebihara, R; Fujii, Y; Itahara, T; Seto, Y; Tada, M | 1 |
| Breter, HJ; Müller, WE; Yamazaki, Z; Zahn, RK | 1 |
| Hitz, HR; Regös, J | 1 |
| Ayad, SR; Fox, M; Winstanley, D | 1 |
| Cox, B; Olive, T; Unrau, P; Wheatcroft, R | 1 |
| al-Nuri, MA; Glaser, VM; Groshev, VV; Shestakov, SV | 1 |
| Fogt, SM; Price, AR | 2 |
| Harris, WJ | 1 |
| Marmur, J; Neubort, S | 1 |
| Arwert, F; Venema, G | 1 |
| Daneo-Moore, L; Higgins, ML | 1 |
| Mendelson, NH; Reeve, JN | 1 |
| Killion, K; Rao, KV; Tanrikut, Y | 1 |
| Dunham, LT; Price, AR | 1 |
| Price, AR | 1 |
| Stroman, P | 1 |
| Geissler, E | 1 |
| Constantin, T | 1 |
| Kaempe, B | 1 |
| Diez, J; Lorek, H | 1 |
| Halvorson, HO; Steinberg, W | 1 |
| Grossowicz, N; Mandelbaum-Shavit, F | 1 |
| Chauchard, J; Chauchard, P; Lecoq, R; Mazoué, H | 1 |
| Guillet, L; Nofre, C | 1 |
| Kobayashi, Y | 1 |
| Fox, BW; Perkins, JP; Prusoff, WH | 1 |
| Abbott, MT; Liu, CK; McCroskey, RP; Shaffer, PM; Slaughter, RS | 1 |
| Lazdunski, A; Shapiro, BM; Siccardi, AG | 1 |
| Turian, G | 1 |
| Dávila, CA; García-Pineda, D; Reuvers, T | 1 |
| Abbott, MT; Hsu, CA; Liu, CK | 1 |
| Bryan, AM; Olafsson, PG | 1 |
| Pihl, A; Sanner, T | 1 |
| Holmes, DE; Ingalls, RB; Myers, LS | 1 |
| Ormerod, MG; Singh, BB | 1 |
| Cook, JB; Wyard, SJ | 1 |
| Bernhard, W; Snipes, W | 1 |
| Ratapongs, C | 1 |
| Chkheidze, II; Gaponova, IS; Lebedev, IaS; Mikhaĭlov, AI | 1 |
| Glass, JW; Holroyd, RA | 1 |
| McMillan, M; Nicolau, C; Norman, RO | 1 |
| Khym, JX; Uziel, M | 1 |
| Dennis, PP; Herman, RK | 1 |
| Eckstein, F | 1 |
| Gopal-Ayengar, AR; Tatake, VG | 1 |
| Neta, P | 1 |
| Avery, EC; Nucifora, G; Remko, R; Smaller, B | 1 |
| Arima, K; Beppu, T | 1 |
| Phelps, P; Tse, RL; Urban, D | 1 |
| Conigliaro, PJ; Wolfrom, ML | 1 |
| Busch, H; Choi, YC; Henning, D; Reddy, R; Ro-Choi, TS; Shibata, H | 1 |
| Lagercrantz, C | 1 |
| Kleppe, K; Ovrebo, S | 1 |
| Hüttermann, J; Müller, A | 1 |
| Hochstadt, J | 1 |
| Lindsay, RH; Yu, MW | 1 |
| Bacher, A; Lingens, F; Oltmanns, O | 1 |
| Clauwaert, J; Stockx, J | 1 |
| Friedmann, E; Gampel, Z; González, J; Pieber, M; Romero, C; Tohá, J | 1 |
| Agarwal, DP; Eickhoff, K; Goedde, HW | 2 |
| Smith, AE; Yamada, EW | 1 |
| Morris, HP; Queener, SF; Weber, G | 1 |
| Mandel, HG; Riis, M | 1 |
| Arcaya, G; Pantoja, ME; Pieber, M; Romero, C; Tohá, JC | 1 |
| Díaz, E; Grez, M; Hasbún, S; Lyon, F; Pieber, M; Romero, C; Sánchez, G; Tohá, JC | 1 |
| Gilbert, E; Wagner, G | 1 |
| Pennazio, S; Redolfi, P | 1 |
| Hanisch, ME; Lawrence, AL | 1 |
| Hyatt, JA; Swenton, JS | 1 |
| Kulakowska, I; Rabczenko, A | 1 |
| Schott, HN; Shetlar, MD | 1 |
| Pacáková, V; Rehák, V | 1 |
| Cundall, RL; Leonard, NJ | 1 |
| Bobick, S; Brown, PR; Hanley, FL | 1 |
| Liska, B; Smith, PF | 1 |
| Geller, M; Kulakowska, I; Lesyng, B; Wierzchowski, KL | 1 |
| Kahn, PL; Ley, AN; Warner, HR | 1 |
| Daniels, M | 1 |
| Rae, PM | 1 |
| Arnason, BG; Chelmicka-Szorc, E; Darzynkiewicz, Z | 1 |
| Harrington, JP; Herskovits, TT | 1 |
| Barszcz, D; Fielden, EM | 1 |
| Nunn, WD; Tropp, BE | 1 |
| Rehberg, R; Scheie, PO | 1 |
| Medoff, G | 1 |
| Dobisová, M; Hirsch, I; Vondrejs, V | 1 |
| Varricchio, F | 1 |
| Arima, K; Beppu, T; Kawabata, K | 1 |
| Wilkins, AS | 1 |
| Koch, AL; Norris, TE | 1 |
| Fu, AS; Moyer, RW; Szabo, C | 1 |
| Pavlasová, E; Stejskalová, E; Strbánová-Necinová, S | 1 |
| Finn, PD; Hoeprich, PD | 1 |
| Srinivasan, PR; Young, DV | 1 |
| Couse, NL; Cummings, DJ; Haworth, P; Moody, W | 1 |
| Ikenaga, M; Jido, Y; Sidei, T | 1 |
| Ban, J; Kos, E; Vitale, L | 1 |
| Friesen, JD; Roback, ER | 1 |
| Beck, DJ; Brubaker, RR | 1 |
| Pine, MJ | 1 |
| Kelln, RA; Warren, RA | 1 |
| Allerhand, A; Komoroski, RA | 1 |
| Johns, HE; Whillans, DW | 3 |
| Braun, ML; Ferrell, DW; Ott, JL | 1 |
| Glaser, DA; Waskell, L | 1 |
| Bergter, F; Hilliger, M | 1 |
| Karlström, O; Lindahl, T | 1 |
| Birnboim, HC; Nassim, A | 1 |
| Deutch, CE; Pauling, C | 1 |
| Opekarová, M; Vondrejs, V | 1 |
| Javor, GT | 1 |
| Breter, HJ; Weinblum, D; Zahn, RK | 1 |
| Lancini, GC; Pirali, G; Sala, F; Somma, S | 1 |
| Brozmanová, J; Sedliaková, M | 1 |
| Lindahl, T | 1 |
| Halvorson, HO; Rana, RS | 1 |
| Beebe, JL | 1 |
| Hedges, AJ; Timmis, K | 1 |
| Cook, SJ; Price, AR | 1 |
| Wysor, MS; Zollinhofer, RE | 1 |
| Ohmann, E; Rindt, KP | 1 |
| Bishop, RJ; Sueoka, N | 1 |
| Köhnlein, W; Mönkehaus, F | 1 |
| Strniste, GF; Taylor, WD | 1 |
| Konvicková-Lamosová, M; Reich, J; Soska, J | 1 |
| Cyr, WH; Pollard, EC | 1 |
| Fraser, L; Harris, WJ; Mitchell, AI | 1 |
| Behki, RM; Lesley, SM | 2 |
| Merwitz, O | 2 |
| Finch, RG; Hutchison, JG; McGhie, D | 1 |
| Leshem, B; Steinschneider, A | 1 |
| Hayon, E; Simic, M | 1 |
| Sander, EG; Sedor, FA | 1 |
| McAllan, AB; Smith, RH | 2 |
| Cundall, RL; Leonard, NJ; Logue, MW; McCredie, RS | 1 |
| Pappas, PW; Read, CP; Uglem, GL | 1 |
| Crewe, AV; Isaacson, M; Johnson, D | 2 |
| Mathur, CF; Smith, RC | 1 |
| Fabre, F; Moustacchi, E | 1 |
| Tomasz, J | 1 |
| Bacon, V; Duffield, AM; Halpern, B; Hoyano, Y; Pereira, WE; Summons, RE | 1 |
| Askerov, DB; Ivanchenko, VA; Tishchenko, AI; Vul'fson, NS | 1 |
| Brandon, C; Hayashi, H; Marmur, J; Nakanishi, K | 1 |
| Kuzina, ZA; Tereshin, IM | 1 |
| Svetlova, LL; Tereshin, IM | 1 |
| Hayon, E; Rao, PS | 1 |
| Behrman, EJ; Moschel, RC | 1 |
| Bärwolff, D; Langen, P; Matthes, E | 1 |
| Elad, D; Leonov, D | 1 |
| Fisher, GJ; Johns, HE; Varghese, AJ | 1 |
| Pietrzykowska, I; Shugar, D | 1 |
| Astrachan, L; Sicard, N; Simonnet, G | 1 |
| Billen, D; Hewitt, R; Jorgensen, G | 2 |
| Budman, DR; Pardee, AB | 1 |
| Boyle, JV; Cook, TM; Goss, WA | 1 |
| Cohen, SS; Jansen, M; Raina, A | 1 |
| Person, S; Sclair, MH | 1 |
| Shaw, MK | 1 |
| Eberle, H | 1 |
| Lion, MB | 1 |
| Abe, M; Tomizawa, J | 1 |
| Doskocil, J; Paces, V | 1 |
| Anderson, D; Kaplan, S | 1 |
| Smith, RC | 1 |
| Antonov, AS; Belozerskiĭ, AN; Liutskanov, N | 1 |
| Brozmanová, J; Masek, F; Sedliaková, M | 1 |
| Fraser, DK; Porter, B | 1 |
| Hanawalt, P; Kanner, L | 1 |
| Guéron, M; Shulman, RG | 1 |
| Hernádi, F; Kovács, P; Nagy, Z; Vályi-Nagy, T | 1 |
| Pollard, EC; Weller, PK | 2 |
| Binkley, SB; Carpenter, C | 1 |
| Apel, D; Methfessel, J; Schmidt, R; Schultka, R | 1 |
| Hashizume, T; Sasaki, Y | 1 |
| Massaro, EJ | 1 |
| Iwashima, A; Kawasaki, T; Nakamura, M; Nose, Y | 1 |
| Orgel, LE | 1 |
| Lancini, G; Pallanza, R; Silvestri, LG | 1 |
| Chan, H; Lark, KG | 1 |
| Hagerman, DD | 1 |
| Booth, AD; Webb, SJ | 1 |
| Brossmer, R; Ziegler, D | 1 |
| Esser, HO; Mücke, W; Müller, PW | 1 |
| Cruceanu, A | 1 |
| Pollard, EC; Yayanos, AA | 1 |
| Hanawalt, P; Stein, G | 1 |
| Shugar, D; Swierkowski, M | 1 |
| Yan, Y | 1 |
| Bernstein, RL; Sellin, HG; Srinivasan, PR | 1 |
| Frampton, EW; Mandel, M | 1 |
| Lee, SS | 1 |
| Hernádi, F; Kari, C; Kovács, P; Nagy, Z | 1 |
| Donini, P | 1 |
| Billen, D; Bruns, LH | 1 |
| Patrick, MH | 1 |
| Ikenaga, M; Jagger, J; Patrick, MH | 1 |
| Heidelberger, C | 1 |
| Cohen, SS; Nass, MM; Rubenstein, KE | 1 |
| Datta, B; Poddar, RK | 1 |
| Hirsch, I; Janderová, B; Tkadlecek, L; Vondrejs, V | 1 |
| Hirsch, I; Vondrejs, V | 1 |
| Hewitt, RR; Jones, RJ | 1 |
| Deutsch, CE; Pauling, C | 1 |
| Lundquist, R; Olivera, BM | 1 |
| Lamola, AA | 1 |
| Bernátová, L; Sedliaková, M; Stefunková, E | 1 |
| Hirsch, I; Janderová, B; Vondrejs, V | 1 |
| Kaiser, C; McCalla, DR; Reuvers, A | 1 |
| Camakaris, J; Cotton, RG; Danks, DM | 1 |
| Breitman, TR; Finkleman, A; Rabinovitz, M | 1 |
| Nicolau, C; Singh, BB | 1 |
| Turcu, G | 1 |
| Czerniawski, E; Pajkowska, H; Sedlaczek, L | 1 |
| Hiraga, S | 1 |
| Duncan, JF; Kingsbury, DT | 1 |
| Bodmer, WF; Laird, CD | 1 |
| Günther, HL; Prusoff, WH | 1 |
| Gross, JD; Mendelson, NH | 1 |
| O'Sullivan, A; Sueoka, N | 1 |
| Koukalová, B; Reich, J; Soska, J | 1 |
| Godson, GN; Sinsheimer, RL | 1 |
| Anraku, N; Landman, OE | 1 |
| Kirschfeld, S; Wacker, A; Weinblum, D | 1 |
| Pol'kina, RI | 1 |
| Takahashi, I; Yamagishi, H | 1 |
| Bryant, SR; Kruse, PF; Masingale, RE; Nash, J; Skinner, CG | 1 |
| Friedman, N; Nishihara, M; Vasken Aposhian, H | 1 |
| Bilello, JA; Lang, PA; Rouhandeh, H | 1 |
| Lancini, GC; Sartori, G | 1 |
| Ennis, HL; Willis, DB | 1 |
| Coleman, GS | 1 |
| Roscoe, DH | 1 |
| Hayward, J | 1 |
| Fahr, E | 1 |
| Imada, A; Kawashima, F; Kida, M; Nogami, I; Suhara, I | 1 |
| Bobikov, EV; Sazykin, IuO | 1 |
| Koukalová, B | 1 |
| Chai, NC; Lark, KG | 1 |
| Kaltwasser, H; Krämer, J | 1 |
| Hales, HB; Hutchinson, F | 1 |
| Brack, C; Delain, E; Festy, B; Lallemant, AM; Riou, G | 1 |
| Vigny, P | 1 |
| Marcus, M; Newlon, MC | 1 |
| Rusakov, VI | 2 |
| Ottensmeyer, FP; Whiting, RF | 1 |
| Antonovskiĭ, VL; Gukovskaia, AS; Prokop'eva, TM; Sukhoroukov, BI | 1 |
| Doerner, T; Lion, MB | 1 |
| Cooper, GM; Dunning, WF; Greer, S | 1 |
| Ferdinandus, JA; Weber, G | 1 |
| Meistrich, ML; Rauth, AM | 1 |
| Fenselau, C; Hahn, BS; Wang, SY; Zafiriou, OC | 1 |
| Dorsett, MT; Gentry, GA; Morse, PA | 1 |
| Fielden, EM; Lillicrap, SC | 1 |
| Kusaka, T | 1 |
| Gehrke, CW; Lakings, DB | 1 |
| Cernohorský, IJ; Miller, V; Pacáková, V | 1 |
| Bangerter, BW; Chan, SI; Peter, HH | 1 |
| Bollum, FJ; Carrier, WL; Setlow, RB | 1 |
| Klímek, M; Vlasínová, M | 1 |
| Green, JH; Khattak, MN | 1 |
| Myers, LS; Ward, JF; Zimbrick, JD | 1 |
| Isoun, M; Trosko, JE | 1 |
| de Graaf, FK; Stouthamer, AH | 1 |
| Charlier, M; Helene, C | 1 |
| Judis, J | 1 |
| Harrison, AP; Moore, BG | 1 |
| Denhardt, DT; Sinsheimer, RL | 1 |
| Piechowska, M; Shugar, D | 1 |
| Forro, F | 1 |
| Chargaff, E; Karkas, JD; Türler, H | 1 |
| Achey, PM; Pollard, EC | 1 |
| Billen, D; Frampton, EW | 1 |
| Hanawalt, P; Pauling, C | 1 |
| Hodgkins, B; O'Leary, ME; Smith, KC | 1 |
| Munch-Petersen, A; Neuhard, J | 2 |
| Fucík, V; Sormová, Z; Zadrazil, S | 1 |
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| Article | Year |
|---|---|
Bisulfite modification of nucleic acids and their constituents.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Cysteine; Cytosine; DNA; Hydrogen-Ion Concentration; Nucleic Acid Conformation; Poly C; Poly U; Polynucleotides; Pseudouridine; Pyrimidines; Sulfites; Sulfonic Acids; Thymine; Uracil | 1976 |
Molecular aspects of chemical radiosensitization.
Topics: Acetophenones; Cyclic N-Oxides; Diamide; Electron Transport; Ethylmaleimide; Free Radicals; Metronidazole; Nitrofurans; Propiophenones; Radiation-Sensitizing Agents; Thymine; Uracil; Vitamin K | 1977 |
Molecular recognition and self-replication.
Topics: Base Composition; Hydrogen Bonding; Molecular Structure; Nucleic Acids; Proteins; Thymine; Uracil | 1992 |
The radiolysis of pyrimidines in aqueous solutions: an updating review.
Topics: Cytosine; DNA; Free Radicals; Gamma Rays; Hydroxides; Hydroxyl Radical; Nucleosides; Nucleotides; Oxygen; Pyrimidines; Radiation-Sensitizing Agents; Solutions; Thymine; Uracil; Water | 1986 |
The role of the membrane in the utilization of nucleic acid precursors.
Topics: Adenine; Adenosine; Bacillus subtilis; Biological Transport; Cell Membrane; Chromatography, Gel; Cytosine; DNA; Escherichia coli; Guanine; Guanosine; Hydrogen-Ion Concentration; Hypoxanthines; Inosine; Kinetics; Pentosephosphates; Pentosyltransferases; Phosphoric Acids; Purines; Pyrimidines; RNA; Thymine; Uracil; Xanthines | 1974 |
Photochemistry and the triplet state of nucleic acids.
Topics: Acetone; Acetophenones; Adenosine Monophosphate; Benzophenones; Cysteine; Cytosine; DNA; Energy Transfer; Freezing; Lasers; Luminescent Measurements; Orotic Acid; Photolysis; Radiation Effects; Radiation-Sensitizing Agents; RNA; Solutions; Temperature; Thymine; Ultraviolet Rays; Uracil; Water | 1973 |
Photochemistry of nucleic acids and their constituents.
Topics: Amino Acids; Cyclobutanes; Cytosine; Deoxyribodipyrimidine Photo-Lyase; DNA; Halogens; Oxidation-Reduction; Photochemistry; Purines; Pyrimidine Nucleotides; Pyrimidines; Radiation Effects; Radiochemistry; RNA; Sugar Phosphates; Thymine; Ultraviolet Rays; Uracil | 1972 |
Energy transfer in polynucleotides.
Topics: Acridines; Adenine; DNA; Energy Transfer; Light; Nucleotides; Temperature; Thymine; Uracil | 1968 |
[Gas chromatography of nucleic acid components].
Topics: Adenine; Chromatography, Gas; Cytosine; DNA; Guanine; Methods; Nucleic Acids; Nucleotides; Purines; Pyrimidines; RNA; Thymine; Uracil | 1968 |
The molecular basis of embryonic development.
Topics: Adenine; Amino Acid Sequence; Animals; DNA; Embryology; Enzymes; Genetic Code; Glucose; Guanine; Humans; Isoenzymes; L-Lactate Dehydrogenase; Mice; Protein Biosynthesis; Ribosomes; RNA, Messenger; RNA, Transfer; Thymine; Uracil | 1969 |
The chemical basis of mutation.
Topics: Acridines; Adenine; Alkylation; Bromodeoxyuridine; Coliphages; Cytosine; DNA; DNA Replication; Escherichia coli; Genetic Code; Hydrazines; Hydrogen-Ion Concentration; Hydroxylamines; Hypoxanthines; Methylene Blue; Molecular Biology; Mutagens; Mutation; Nitrites; Nucleic Acid Denaturation; Nucleic Acids; Radiation Effects; RNA; Thymine; Ultraviolet Rays; Uracil; Xanthines | 1965 |
An introduction to some concepts of molecular biology.
Topics: Adenine; Amino Acid Sequence; Bacteriophages; Cell Differentiation; Cytosine; DNA; DNA Nucleotidyltransferases; Embryonic and Fetal Development; Enzyme Induction; Enzyme Repression; Escherichia coli; Galactosidases; Genetic Code; Guanine; RNA; RNA Nucleotidyltransferases; RNA, Messenger; Thymine; Uracil; Viruses | 1969 |
[Action of ultraviolet rays on nucleic acids and their constituents].
Topics: Cytosine; Nucleic Acids; Nucleotides; Purines; Pyrimidines; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1969 |
Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture.
Topics: Animals; Antineoplastic Agents; Arginase; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Deoxyribonucleases; DNA; Fluorouracil; Humans; Liver Neoplasms; Methylcholanthrene; Mice; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Oncogenic Viruses; Orotic Acid; Phenanthrenes; Protein Binding; Pyrimidinones; Rats; Skin Neoplasms; Thymine; Uracil | 1970 |
Short-lived free radicals in aqueous solutions of biomolecules.
Topics: Amino Acids; Bromouracil; Caffeine; Chemistry, Organic; Cytosine; Disulfides; Electrons; Free Radicals; Hydrogen Peroxide; Nucleic Acids; Nucleosides; Nucleotides; Organic Chemistry Phenomena; Orotic Acid; Peptides; Proteins; Purines; Pyrimidines; Sulfhydryl Compounds; Thymine; Uracil | 1971 |
[Effect of ultraviolet radiation on the bacterial deoxyribonucleic acid].
Topics: Chemical Phenomena; Chemistry; Cytosine; DNA, Bacterial; Escherichia coli; Micrococcus; Models, Chemical; Nucleic Acid Denaturation; Radiation Effects; Temperature; Thymine; Ultraviolet Rays; Uracil | 1971 |
Modified bases in bacteriophage DNAs.
Topics: 2-Aminopurine; 5-Methylcytosine; Adenine; Bacteriophages; Base Composition; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytosine; Deoxyribonucleases; DNA Replication; DNA, Viral; Nucleic Acid Conformation; Pentoxyl; Substrate Specificity; Templates, Genetic; Thymine; Transcription, Genetic; Uracil | 1980 |
A base called J.
Topics: Animals; DNA, Protozoan; Eukaryota; Evolution, Molecular; Glucosides; Humans; Repetitive Sequences, Nucleic Acid; Telomere; Thymine; Trypanosoma brucei brucei; Trypanosomiasis, African; Uracil; Variant Surface Glycoproteins, Trypanosoma | 1998 |
[Dihydropyrimidine dehydrogenase deficiency].
Topics: Diagnosis, Differential; Dihydrouracil Dehydrogenase (NADP); Humans; Mutation; Oxidoreductases; Prognosis; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 1998 |
Thymine DNA glycosylase.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Pair Mismatch; Base Sequence; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytosine; Deamination; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; DNA, Neoplasm; Endodeoxyribonucleases; Evolution, Molecular; Guanine; Humans; Mice; Models, Genetic; Molecular Sequence Data; Receptors, Retinoic Acid; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity; Thymine; Transcription, Genetic; Transfection; Uracil | 2001 |
Nucleobases as supramolecular motifs.
Topics: Adenine; Cytosine; DNA; Guanine; Nucleic Acid Conformation; Purines; Pyrimidines; RNA; Thymine; Uracil; Zinc; Zinc Fingers | 2005 |
Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Biological Availability; Clinical Trials as Topic; Drug Combinations; Drug Delivery Systems; Drug Resistance, Neoplasm; Forecasting; Gastrointestinal Neoplasms; Humans; Pyrimidines; Pyrrolidines; Thymidine; Thymine; Trifluridine; Uracil | 2007 |
Electronic spectra, excited state structures and interactions of nucleic acid bases and base assemblies: a review.
Topics: Adenine; Base Pairing; Cytosine; DNA; Guanine; Molecular Structure; Nucleic Acid Conformation; Nucleic Acids; Spectrophotometry; Thymine; Uracil | 2007 |
Excitation of nucleobases from a computational perspective I: reaction paths.
Topics: Adenine; Base Pairing; Cytosine; Electrons; Energy Transfer; Guanine; Models, Theoretical; Molecular Structure; Photochemical Processes; Quantum Theory; Thymine; Ultraviolet Rays; Uracil | 2015 |
Photosynthesis and photo-stability of nucleic acids in prebiotic extraterrestrial environments.
Topics: Absorption, Radiation; Cytosine; Extraterrestrial Environment; Ice; Models, Theoretical; Nucleic Acids; Photons; Photosynthesis; Prebiotics; Radiation, Ionizing; Thymine; Ultraviolet Rays; Uracil | 2015 |
Excited states behavior of nucleobases in solution: insights from computational studies.
Topics: Adenine; Cytosine; Electrons; Energy Transfer; Guanine; Models, Chemical; Models, Molecular; Photochemical Processes; Quantum Theory; Solutions; Solvents; Thymine; Uracil | 2015 |
Modified nucleobases.
Topics: Adenine; Cytosine; Energy Transfer; Fluorescent Dyes; Guanine; Models, Molecular; Molecular Structure; Photochemical Processes; Thymine; Uracil | 2015 |
Photoionization spectroscopy of nucleobases and analogues in the gas phase using synchrotron radiation as excitation light source.
Topics: Adenine; Cytosine; Electrons; Energy Transfer; Guanine; Mass Spectrometry; Models, Theoretical; Molecular Structure; Phase Transition; Photochemical Processes; Photoelectron Spectroscopy; Radiation, Ionizing; Synchrotrons; Thymine; Uracil | 2015 |
Photochemistry of nucleic acid bases and their thio- and aza-analogues in solution.
Topics: Adenine; Aza Compounds; Cytosine; Guanine; Molecular Structure; Photochemical Processes; Solutions; Sulfur Compounds; Thymine; Ultraviolet Rays; Uracil | 2015 |
Excited states in DNA strands investigated by ultrafast laser spectroscopy.
Topics: Adenine; Base Pairing; Cytosine; DNA; DNA, Single-Stranded; Energy Transfer; Guanine; Lasers; Nucleic Acid Conformation; Photochemical Processes; Protons; Spectrum Analysis; Thymine; Time Factors; Ultraviolet Rays; Uracil | 2015 |
UV-excitation from an experimental perspective: frequency resolved.
Topics: Adenine; Base Pairing; Cytosine; Electrons; Energy Transfer; Guanine; Hydrogen Bonding; Molecular Structure; Photochemical Processes; Spectrum Analysis; Stereoisomerism; Thymine; Ultraviolet Rays; Uracil | 2015 |
[Efficacy of TAS-102].
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colorectal Neoplasms; Drug Combinations; Humans; Pyrrolidines; Thymine; Trifluridine; Uracil | 2015 |
TAS-102, a novel antitumor agent: a review of the mechanism of action.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Combinations; Humans; Neoplasms; Pyrrolidines; Thymine; Trifluridine; Uracil | 2015 |
TAS-102 for the treatment of metastatic colorectal cancer.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Humans; Neoplasm Metastasis; Prognosis; Pyrrolidines; Survival Rate; Thymine; Trifluridine; Uracil | 2015 |
Current and advancing treatments for metastatic colorectal cancer.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Camptothecin; Colorectal Neoplasms; Drug Combinations; ErbB Receptors; Humans; Irinotecan; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Panitumumab; Pyrrolidines; Ramucirumab; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Therapies, Investigational; Thymine; Trifluridine; Uracil; Vascular Endothelial Growth Factor A | 2016 |
TAS-102: a novel antimetabolite for the 21st century.
Topics: Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Clinical Trials as Topic; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Neoplasms; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
A novel antimetabolite: TAS-102 for metastatic colorectal cancer.
Topics: Animals; Antineoplastic Agents; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Humans; Neoplasm Metastasis; Pyrrolidines; Randomized Controlled Trials as Topic; Survival Rate; Thymine; Trifluridine; Uracil | 2016 |
TAS-102 an Emerging Oral Fluoropyrimidine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Combinations; Folic Acid Antagonists; Humans; Immunotherapy; Molecular Targeted Therapy; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
[Antitumor Molecular Mechanism of Trifluridine and Tipiracil Hydrochloride (TAS-102: TFTD)].
Topics: Animals; Cell Cycle; Colorectal Neoplasms; DNA; Drug Combinations; Drug Design; Drug Resistance, Neoplasm; Humans; Pyrrolidines; Thymine; Trifluridine; Uracil | 2016 |
TAS-102 for Treatment of Advanced Colorectal Cancers That Are No Longer Responding to Other Therapies.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Male; Pyrrolidines; Thymidylate Synthase; Thymine; Trifluridine; Uracil | 2016 |
Review on TAS-102 development and its use for metastatic colorectal cancer.
Topics: Animals; Clinical Trials as Topic; Colorectal Neoplasms; Drug Combinations; Humans; Pyrrolidines; Thymine; Trifluridine; Uracil | 2016 |
TAS-102 (Lonsurf) for the Treatment of Metastatic Colorectal Cancer. A Concise Review.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Drug Combinations; Humans; Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Trifluridine; Uracil | 2016 |
Adherence, Dosing, and Managing Toxicities With Trifluridine/Tipiracil (TAS-102).
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Combinations; Humans; Medication Adherence; Neoplasm Metastasis; Pyrrolidines; Thymine; Trifluridine; Uracil | 2017 |
The Role of Fluoropirimidines in Gastrointestinal Tumours: from the Bench to the Bed.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Molecular Targeted Therapy; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Pyrrolidines; Thymidine Phosphorylase; Thymidylate Synthase; Thymine; Trifluridine; Uracil | 2017 |
A Comparison of Regorafenib and TAS-102 for Metastatic Colorectal Cancer: A Systematic Review and Network Meta-analysis.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Drug Combinations; Humans; Network Meta-Analysis; Phenylurea Compounds; Pyridines; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
Trifluridine-Tipiracil for Previously Treated Metastatic Colorectal Cancer: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Cost-Benefit Analysis; Drug Combinations; Humans; Pyrrolidines; Technology Assessment, Biomedical; Thymine; Trifluridine; Uracil | 2018 |
Beyond second-line therapy in patients with metastatic colorectal cancer: a systematic review.
Topics: Colorectal Neoplasms; Disease Progression; Drug Combinations; Drugs, Investigational; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Phenylurea Compounds; Pyridines; Pyrrolidines; Thymine; Trifluridine; Uracil | 2018 |
Fluoropyrimidine-induced cardiotoxicity.
Topics: Acetates; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyrimidines; Pyrrolidines; Quinazolines; Thiophenes; Thymine; Trifluridine; Uracil; Uridine | 2018 |
Trifluridine/tipiracil: an emerging strategy for the management of gastrointestinal cancers.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Clinical Trials as Topic; Colonic Neoplasms; Docetaxel; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Immunotherapy; Indoles; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Pyrrolidines; Quality of Life; Taxoids; Thymine; Trifluridine; Uracil | 2018 |
The safety of trifluridine and tipiracil for the treatment of metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Humans; Molecular Targeted Therapy; Neoplasm Metastasis; Pyrrolidines; Survival Rate; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
A Systematic Review and Network Meta-Analysis of Regorafenib and TAS-102 in Refractory Metastatic Colorectal Cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Humans; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Randomized Controlled Trials as Topic; Survival Rate; Thymine; Treatment Outcome; Trifluridine; Uracil | 2019 |
The safety and efficacy of trifluridine-tipiracil for metastatic colorectal cancer: A pharmacy perspective.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Humans; Progression-Free Survival; Pyrrolidines; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil | 2019 |
Comparison of Regorafenib, Fruquintinib, and TAS-102 in Previously Treated Patients with Metastatic Colorectal Cancer: A Systematic Review and Network Meta-Analysis of Five Clinical Trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzofurans; Colonic Neoplasms; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Humans; Network Meta-Analysis; Phenylurea Compounds; Pyridines; Pyrrolidines; Quinazolines; Rectal Neoplasms; Thymine; Trifluridine; Uracil | 2019 |
Regorafenib, TAS-102, or fruquintinib for metastatic colorectal cancer: any difference in randomized trials?
Topics: Antineoplastic Agents; Benzofurans; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Disease Progression; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Network Meta-Analysis; Phenylurea Compounds; Progression-Free Survival; Pyridines; Pyrrolidines; Quinazolines; Randomized Controlled Trials as Topic; Thymine; Time Factors; Trifluridine; Uracil | 2020 |
Metastatic Colorectal Carcinoma after Second Progression and the Role of Trifluridine-Tipiracil (TAS-102) in Switzerland.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Disease Progression; Drug Combinations; Humans; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Survival Rate; Switzerland; Thymine; Treatment Outcome; Trifluridine; Uracil | 2020 |
Functional Systems Derived from Nucleobase Self-assembly.
Topics: Adenine; Base Pairing; Coordination Complexes; Cytosine; DNA; Electron Transport; Energy Transfer; Guanine; Molecular Conformation; Oxidation-Reduction; Surface Properties; Thymine; Uracil | 2020 |
TAS-102 in gastric cancer: Development and perspectives of a new biochemically modulated fluroropyrimidine drug combination.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biochemical Phenomena; Drug Combinations; Humans; Pyrrolidines; Stomach Neoplasms; Thymine; Trifluridine; Uracil | 2020 |
Systematic review and network meta-analyses of third-line treatments for metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Colorectal Neoplasms; Double-Blind Method; Drug Combinations; Humans; Microspheres; Neoplasm Metastasis; Network Meta-Analysis; Palliative Care; Phenylurea Compounds; Progression-Free Survival; Pyridines; Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Trifluridine; Uracil; Yttrium Radioisotopes | 2020 |
From Nucleic Acids to Drug Discovery: Nucleobases as Emerging Templates for Drug Candidates.
Topics: Adenine; Cytosine; Drug Discovery; Humans; Nucleic Acids; Pharmaceutical Preparations; Thymine; Uracil | 2021 |
Photoreaction of DNA Containing 5-Halouracil and its Products.
Topics: Bromouracil; DNA; Thymine; Uracil | 2022 |
Effect of KRAS codon 12 or 13 mutations on survival with trifluridine/tipiracil in pretreated metastatic colorectal cancer: a meta-analysis.
Topics: Codon; Colonic Neoplasms; Colorectal Neoplasms; Frontotemporal Dementia; Humans; Mutation; Proto-Oncogene Proteins p21(ras); Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Trifluridine; Uracil | 2022 |
30 trial(s) available for thymine and uracil
| Article | Year |
|---|---|
Phase I study to determine the safety and pharmacokinetics of oral administration of TAS-102 in patients with solid tumors.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Area Under Curve; Asthenia; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nausea; Neoplasms; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; Uracil | 2006 |
Phase 1 study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrrolidines; Thymine; Trifluridine; Uracil | 2008 |
Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrrolidines; Thymine; Trifluridine; Uracil | 2008 |
Phase I study of TAS-102 treatment in Japanese patients with advanced solid tumours.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asian People; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrrolidines; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil | 2012 |
TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Mutation; Neoplasm Metastasis; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyrrolidines; ras Proteins; Thymine; Trifluridine; Uracil | 2012 |
Randomized trial of TAS-102 for refractory metastatic colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Proportional Hazards Models; Pyrrolidines; Survival Analysis; Thymine; Trifluridine; Uracil | 2015 |
TAS-102 for metastatic refractory colorectal cancer.
Topics: Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Male; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Pyrrolidines; Risk Assessment; Survival Analysis; Thymine; Treatment Outcome; Trifluridine; Uracil | 2015 |
Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Combinations; Female; Glucuronosyltransferase; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Polymorphism, Genetic; Proto-Oncogene Proteins p21(ras); Pyrrolidines; Thymine; Trifluridine; Uracil | 2015 |
Phase 1 study of oral TAS-102 in patients with refractory metastatic colorectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Combinations; Fatigue; Febrile Neutropenia; Female; Gastrointestinal Diseases; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Pyrrolidines; Salvage Therapy; Thymine; Treatment Outcome; Trifluridine; Uracil | 2015 |
Human mass balance study of TAS-102 using (14)C analyzed by accelerator mass spectrometry.
Topics: Aged; Antineoplastic Agents; Chromatography, Liquid; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasms; Pyrimidines; Pyrrolidines; Tandem Mass Spectrometry; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil | 2016 |
Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors.
Topics: Aged; Anemia; Antineoplastic Agents; Area Under Curve; Asian People; Biological Availability; Cross-Over Studies; Drug Combinations; Fasting; Female; Food-Drug Interactions; Humans; Japan; Leukopenia; Male; Middle Aged; Nausea; Neoplasms; Neutropenia; Pyrrolidines; Thymine; Trifluridine; Uracil | 2016 |
Phase 1 study of cardiac safety of TAS-102 in patients with advanced solid tumors.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cardiotoxicity; Drug Administration Schedule; Drug Combinations; Electrocardiography; Electrocardiography, Ambulatory; Female; Heart; Humans; Male; Middle Aged; Neoplasms; Pyrrolidines; Thymine; Trifluridine; Uracil | 2016 |
A multicenter phase II study of TAS-102 monotherapy in patients with pre-treated advanced gastric cancer (EPOC1201).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Middle Aged; Pyrrolidines; Stomach Neoplasms; Thymine; Trifluridine; Uracil | 2016 |
Efficacy of trifluridine and tipiracil (TAS-102) versus placebo, with supportive care, in a randomized, controlled trial of patients with metastatic colorectal cancer from Spain: results of a subgroup analysis of the phase 3 RECOURSE trial.
Topics: Adult; Aged; Aged, 80 and over; Antiviral Agents; Colorectal Neoplasms; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Staging; Palliative Care; Prognosis; Pyrrolidines; Spain; Survival Rate; Thymine; Trifluridine; Uracil | 2017 |
A phase 2 randomized study of TAS-102 versus topotecan or amrubicin in patients requiring second-line chemotherapy for small cell lung cancer refractory or sensitive to frontline platinum-based chemotherapy.
Topics: Adult; Aged; Anthracyclines; Antineoplastic Agents; Drug Combinations; Female; Humans; Male; Middle Aged; Platinum; Pyrrolidines; Small Cell Lung Carcinoma; Thymine; Topotecan; Treatment Outcome; Trifluridine; Uracil | 2016 |
Estimating 12-week death probability in patients with refractory metastatic colorectal cancer: the Colon Life nomogram.
Topics: Aged; Colon; Colorectal Neoplasms; Cost-Benefit Analysis; Disease-Free Survival; Drug Combinations; Female; Humans; Logistic Models; Male; Middle Aged; Neoplasm Metastasis; Nomograms; Phenylurea Compounds; Prognosis; Proportional Hazards Models; Pyridines; Pyrrolidines; Thymine; Trifluridine; Uracil | 2017 |
A Phase 1, Open-Label, Randomized, Crossover Study Evaluating the Bioavailability of TAS-102 (Trifluridine/Tipiracil) Tablets Relative to an Oral Solution Containing Equivalent Amounts of Trifluridine and Tipiracil.
Topics: Administration, Oral; Aged; Antineoplastic Agents; Biological Availability; Cross-Over Studies; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasms; Pyrrolidines; Solutions; Tablets; Thymine; Treatment Outcome; Trifluridine; Uracil | 2017 |
TAS-102 plus bevacizumab for patients with metastatic colorectal cancer refractory to standard therapies (C-TASK FORCE): an investigator-initiated, open-label, single-arm, multicentre, phase 1/2 study.
Topics: Adenocarcinoma; Adult; Aged; Angiogenesis Inhibitors; Bevacizumab; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Drug Therapy, Combination; Female; Humans; Japan; Male; Middle Aged; Pyrrolidines; Thymine; Trifluridine; Uracil | 2017 |
Results of a Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Trifluridine/Tipiracil (TAS-102) Monotherapy in Asian Patients With Previously Treated Metastatic Colorectal Cancer: The TERRA Study.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Asia; Colorectal Neoplasms; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Humans; Male; Middle Aged; Mutation; Progression-Free Survival; Proto-Oncogene Proteins p21(ras); Pyrrolidines; Thymine; Time Factors; Trifluridine; Uracil; Young Adult | 2018 |
The subgroups of the phase III RECOURSE trial of trifluridine/tipiracil (TAS-102) versus placebo with best supportive care in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Double-Blind Method; Drug Combinations; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
Cost-effectiveness Analysis of Regorafenib and TAS-102 in Refractory Metastatic Colorectal Cancer in the United States.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Cost-Benefit Analysis; Double-Blind Method; Drug Combinations; Drug Resistance, Neoplasm; Follow-Up Studies; Humans; Liver Neoplasms; Markov Chains; Palliative Care; Phenylurea Compounds; Prognosis; Pyridines; Pyrrolidines; Quality-Adjusted Life Years; Salvage Therapy; Survival Rate; Thymine; Trifluridine; United States; Uracil | 2018 |
Safety of trifluridine/tipiracil in an open-label expanded-access program in elderly and younger patients with metastatic colorectal cancer.
Topics: Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Progression-Free Survival; Pyrrolidines; Research Design; Thymine; Trifluridine; Uracil; Withholding Treatment | 2018 |
Trifluridine/tipiracil versus placebo in patients with heavily pretreated metastatic gastric cancer (TAGS): a randomised, double-blind, placebo-controlled, phase 3 trial.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Disease Progression; Double-Blind Method; Drug Combinations; Europe; Female; Humans; Israel; Japan; Male; Middle Aged; Neoplasm Staging; Progression-Free Survival; Pyrrolidines; Stomach Neoplasms; Thymine; Time Factors; Trifluridine; United States; Uracil | 2018 |
Open-label study to evaluate trifluridine/tipiracil safety, tolerability and pharmacokinetics in patients with advanced solid tumours and hepatic impairment.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Bilirubin; Drug Administration Schedule; Drug Combinations; Drug Dosage Calculations; Female; Humans; Liver; Liver Diseases; Male; Middle Aged; Models, Biological; Neoplasms; Pyrrolidines; Severity of Illness Index; Thymine; Treatment Outcome; Trifluridine; United States; Uracil | 2019 |
Phase II Trial of Trifluridine/Tipiracil in Patients with Advanced, Refractory Biliary Tract Carcinoma.
Topics: Biliary Tract; Carcinoma; Humans; Pyrrolidines; Thymine; Trifluridine; Uracil | 2020 |
Retrospective cohort study of trifluridine/tipiracil (TAS-102) plus bevacizumab versus trifluridine/tipiracil monotherapy for metastatic colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil; Young Adult | 2019 |
Neutropenia and survival outcomes in metastatic colorectal cancer patients treated with trifluridine/tipiracil in the RECOURSE and J003 trials.
Topics: Colorectal Neoplasms; Drug Combinations; Humans; Japan; Neutropenia; Pyrrolidines; Thymine; Trifluridine; Uracil | 2020 |
First-line trifluridine/tipiracil plus bevacizumab for unresectable metastatic colorectal cancer: SOLSTICE study design.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Clinical Protocols; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Neoplasm Metastasis; Neoplasm Staging; Pyrrolidines; Research Design; Thymine; Trifluridine; Uracil | 2020 |
TAS-102 with or without bevacizumab in patients with chemorefractory metastatic colorectal cancer: an investigator-initiated, open-label, randomised, phase 2 trial.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prognosis; Pyrrolidines; Salvage Therapy; Survival Rate; Thymine; Trifluridine; Uracil | 2020 |
Pooled safety analysis from phase III studies of trifluridine/tipiracil in patients with metastatic gastric or gastroesophageal junction cancer and metastatic colorectal cancer.
Topics: Adult; Colonic Neoplasms; Colorectal Neoplasms; Esophagogastric Junction; Frontotemporal Dementia; Humans; Neutropenia; Pyrrolidines; Stomach Neoplasms; Thymine; Trifluridine; Uracil | 2022 |
1116 other study(ies) available for thymine and uracil
| Article | Year |
|---|---|
Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine alpha-methylene-gamma-lactones and related derivatives.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Lactones; Leukemia, Experimental; Male; Melanoma; Mice; Neoplasms, Experimental; Rats; Thymine; Uracil | 1977 |
Novel nucleosides as potent influenza viral inhibitors.
Topics: Animals; Antiviral Agents; Cell Line; Dogs; Humans; Influenza A virus; Influenza B virus; Influenza, Human; Purine Nucleosides; Pyrimidine Nucleosides; Structure-Activity Relationship | 2010 |
Reaction of uracil and thymine derivatives with sodium bisulfite. Studies on the mechanism and reduction of the adduct.
Topics: Binding Sites; Hydrogen-Ion Concentration; Kinetics; Mathematics; Oxidation-Reduction; Structure-Activity Relationship; Sulfites; Thymidine; Thymine; Uracil; Uridine | 1976 |
Nucleic acid biosynthesis in rat embryo cells infected with X14 or H-1 parvovirus.
Topics: Adenine; Animals; Cell Nucleus; Culture Techniques; Cytosine; DNA; DNA-Directed RNA Polymerases; Formates; Parvoviridae; Rats; RNA; Thymine; Uracil | 1977 |
A possible prebiotic synthesis of thymine: uracil-formaldehyde-formic acid reaction.
Topics: Chemical Phenomena; Chemistry; Formaldehyde; Formates; Hot Temperature; Hydrogen-Ion Concentration; Spectrophotometry, Infrared; Thymine; Uracil | 1977 |
Temperature dependence of the interfacial behavior of uracil derivatives.
Topics: Adsorption; Electrochemistry; Electrodes; Hydrogen-Ion Concentration; Mercury; Temperature; Thermodynamics; Thymine; Uracil | 1978 |
Photobiological behaviour of bacteria and phages supplemented with aza-analogoues of nucleic acid bases.
Topics: Adenine; Aza Compounds; Azacitidine; Bacillus cereus; Coliphages; Cytosine; Escherichia coli; Nucleosides; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1975 |
Synthesis and the lethality of bleomycin in bacteria.
Topics: Arginine; Bacterial Proteins; Binding Sites; Bleomycin; Cell Survival; Chloramphenicol; DNA, Bacterial; Escherichia coli; RNA, Bacterial; Spermidine; Streptomyces; Thymine; Uracil | 1976 |
Uracil incorporation into nascent DNA of thymine-requiring mutant of Bacillus subtilis 168.
Topics: Bacillus subtilis; Deoxyuracil Nucleotides; DNA Repair; DNA Replication; DNA, Bacterial; Molecular Weight; Mutation; N-Glycosyl Hydrolases; Thymine; Uracil | 1978 |
Metabolism of pyrimidine deoxyribonucleosides in Neurospora crassa.
Topics: Autoradiography; Carbon Radioisotopes; Cell-Free System; Chromatography, Paper; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Mixed Function Oxygenases; Models, Chemical; Mutation; Neurospora; Neurospora crassa; Pyrimidines; Thymidine; Thymine; Uracil | 1975 |
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cell Survival; Drug Synergism; Female; Fetal Death; Floxuridine; Fluorouracil; Forelimb; Genes; Hindlimb; Mice; Mutation; Nucleic Acids; Pregnancy; Protein Precursors; Thymidine; Thymine; Tibia; Toes; Uracil | 1975 |
Depression of uracil uptake by ammonium in Neurospora crassa.
Topics: Ammonia; Biological Transport, Active; Chromosome Mapping; Cytosine; Depression, Chemical; Genes; Kinetics; Mutation; Neurospora; Neurospora crassa; Thymine; Uracil | 1976 |
Free radicals formed by exposure of pyrimidine solids to sodium atoms: an electron spin resonance study.
Topics: Alloxan; Bromouracil; Cytosine; Electron Spin Resonance Spectroscopy; Fluorouracil; Free Radicals; Pyrimidines; Sodium; Thymine; Uracil | 1975 |
E.s.r. of spin-trapped radicals in gamma-irradiated aqueous solutions of nucleic acids and their constituents.
Topics: Cobalt Radioisotopes; Cytidine Monophosphate; Cytosine; Deoxycytidine; DNA; Electron Spin Resonance Spectroscopy; Gamma Rays; Poly U; Thymidine; Thymidine Monophosphate; Thymine; Uracil; Uridine | 1976 |
E.s.r. of free radicals in aqueous solutions of substituted pyrimidines.
Topics: Cytosine; Electron Spin Resonance Spectroscopy; Free Radicals; Solutions; Thymine; Uracil; Water | 1978 |
The protonation of the 5-thymyl radical in single crystals of thymine derivatives: e.s.r. and INDO evidence.
Topics: Chemical Phenomena; Chemistry; Computers; Electron Spin Resonance Spectroscopy; Free Radicals; Protons; Thymine; Uracil | 1979 |
The metabolism of pyrimidines by proteolytic clostridia.
Topics: Barbiturates; Clostridium; Clostridium botulinum; Clostridium tetani; Culture Media; Cytosine; Fermentation; Hydrogen; NAD; NADP; Oxidation-Reduction; Pyrimidines; Thymine; Uracil | 1975 |
Formaldehyde as a probe of DNA structure. II. Reaction with endocyclic imino groups of DNA bases.
Topics: Chemical Phenomena; Chemistry; Deoxyribonucleosides; DNA; Formaldehyde; Hydrogen-Ion Concentration; Imines; Inosine Nucleotides; Kinetics; Polynucleotides; Pyrimidinones; Thermodynamics; Thymine; Thymine Nucleotides; Uracil; Uracil Nucleotides | 1975 |
Purification of thymidine phosphorylase from Escherichia coli and its photoinactivation in the presence of thymine, thymidine, and some halogenated analogs.
Topics: Bromodeoxyuridine; Bromouracil; Chromatography, DEAE-Cellulose; Chromatography, Gel; Escherichia coli; Hydrogen-Ion Concentration; Idoxuridine; Isoelectric Focusing; Kinetics; Pentosyltransferases; Photochemistry; Thymidine; Thymidine Phosphorylase; Thymine; Time Factors; Uracil | 1975 |
Urinary excretion of thymine and uracil in a two-year-old child with a malignant tumor of the brain.
Topics: Adolescent; Brain Neoplasms; Child, Preschool; Female; Fibroblasts; Humans; Leukemia, Lymphoid; Male; Medulloblastoma; Neuroblastoma; Oxidoreductases; Thymine; Uracil | 1979 |
Pulse-radiolysis studies of 8-methoxypsoralen.
Topics: Adenine; Cytosine; Electron Transport; Methoxsalen; Oxidation-Reduction; Pulse Radiolysis; Thymidine; Thymine; Uracil; Water | 1978 |
Catabolism of deoxythymidylate in some trypanosomatids.
Topics: Animals; Eukaryota; Nucleotidases; Thymidine; Thymidine Monophosphate; Thymidine Phosphorylase; Thymine; Thymine Nucleotides; Trypanosoma brucei brucei; Trypanosoma cruzi; Uracil | 1977 |
Radiolabeling of Treponema pallidum (Nichols virulent strain) in vitro with precursors for protein and RNA biosynthesis.
Topics: Amino Acids; Bacterial Proteins; Cycloheximide; Erythromycin; Kinetics; Pyruvates; Serine; Thymine; Treponema pallidum; Uracil; Uridine | 1978 |
The sensitivity of Mycoplasma mycoides var. capri cells to gamma-radiation after growth in a medium containing the thymine analogue 5-vinyluracil.
Topics: Cells, Cultured; Gamma Rays; Mycoplasma mycoides; Radiation Tolerance; Radiation-Sensitizing Agents; Thymine; Uracil | 1979 |
Determination of uracil and thymine and their nucleosides and nucleotides in picomole amounts by gas chromatography mass spectrometry selected ion monitoring.
Topics: Animals; Chromatography, Gas; Female; Humans; Isotope Labeling; Male; Mass Spectrometry; Methods; Microchemistry; Rats; Thymidine; Thymine; Thymine Nucleotides; Uracil; Uracil Nucleotides; Uridine | 1979 |
Diurnal periodicity of uridine uptake by Hymenolepis diminuta.
Topics: Animals; Cestoda; Circadian Rhythm; Hymenolepiasis; Hymenolepis; Intestines; Male; Rats; Thymine; Uracil; Uridine | 1977 |
Metabolites from the sponge Pachymatisma johnstoni; L-6-bromo-hypaphorine, a new amino-acid (and its crystal structure).
Topics: Amino Acids; Animals; Cholestenes; Methods; Porifera; Thymine; Tryptophan; Uracil | 1977 |
Effects of natural pyrimidines and of certain related compounds on the spontaneous activity of the mouse.
Topics: Animals; Azauridine; Barbital; Cytidine; Depression, Chemical; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Motor Activity; Phenobarbital; Pyrimidines; Thymidine; Thymine; Uracil; Uridine | 1978 |
Metabolic fate of pyrimidines and purines in dietary nucleic acids ingested by mice.
Topics: Adenine; Animals; Carbon Radioisotopes; Cytosine; Diet; Kinetics; Male; Mice; Purines; Pyrimidines; RNA; Thymine; Tissue Distribution; Uracil | 1978 |
Synthesis of potential hypolipidemic agents. Reaction of substituted phenyl 2,3-epoxypropyl ethers with adenine, uracil, and thymine.
Topics: Adenine; Animals; Anticholesteremic Agents; Chemical Phenomena; Chemistry; Epoxy Compounds; Glycerol; Hypolipidemic Agents; In Vitro Techniques; Liver; Male; Rats; Thymine; Triglycerides; Uracil | 1978 |
The biosynthesis of natural and unnatural polyoxins by Streptomyces cacaoi.
Topics: Anti-Bacterial Agents; Escherichia coli; Pyrimidine Nucleosides; Streptomyces; Thymine; Uracil | 1976 |
Effects of 9-hydroxyellipticine on growth and macromolecular synthesis in Escherichia coli.
Topics: Alkaloids; Bacterial Proteins; Cell Division; Cell Survival; DNA, Bacterial; Ellipticines; Escherichia coli; Kinetics; Leucine; RNA, Bacterial; Thymine; Uracil | 1976 |
Characteristics of a Bacillus subtilis W23 mutant temperature sensitive for initiation of chromosome replication.
Topics: Autoradiography; Bacillus subtilis; Bacterial Proteins; Bromouracil; Cell Count; Chromosome Mapping; Chromosomes, Bacterial; DNA Replication; DNA, Bacterial; Leucine; Mutagens; Mutation; Nitrosoguanidines; RNA, Bacterial; Temperature; Thymine; Transformation, Genetic; Tritium; Uracil | 1975 |
[Mass-spectrometric study of trimers of nucleic acid nitrogen bases].
Topics: Adenine; Chemical Phenomena; Chemistry; Cytosine; Mass Spectrometry; Nucleic Acids; Thymine; Uracil | 1977 |
Identification and comparative analysis of thymidine phosphorylase in the plasma of healthy subjects and cancer patients.
Topics: Humans; In Vitro Techniques; Neoplasms; Pentosyltransferases; Thymidine; Thymidine Phosphorylase; Thymine; Uracil; Uridine | 1977 |
Energy of association of uracil with Watson-Crick A-T pair.
Topics: Adenine; Chemical Phenomena; Chemistry, Physical; Models, Chemical; Thymine; Transcription, Genetic; Uracil | 1977 |
Incorporation of oxygen-18 into nucleosides and bases.
Topics: Hypoxanthines; Isotope Labeling; Mass Spectrometry; Oxygen Isotopes; Pyrimidinones; Thymine; Time Factors; Uracil; Uridine | 1977 |
The preparation of trans-pyrimidine glycols by near-UV irradiation.
Topics: Glycols; Magnetic Resonance Spectroscopy; Methods; Molecular Conformation; Pyrimidines; Stereoisomerism; Thymine; Ultraviolet Rays; Uracil | 1977 |
Synthesis of uracil and thymine under simulated prebiotic conditions.
Topics: Acetates; Alanine; Chemical Phenomena; Chemistry; Hot Temperature; Minerals; Photolysis; Propionates; Thymine; Ultraviolet Rays; Uracil; Urea; Water | 1977 |
Effects of ultrasound on nucleic acid bases.
Topics: Adenine; Cytosine; Gases; Guanine; Kinetics; Structure-Activity Relationship; Thymine; Time Factors; Ultrasonics; Uracil | 1977 |
Energy transfer in fluorescent derivatives of uracil and thymine.
Topics: Energy Transfer; Fluorescence; Photochemistry; Thymine; Uracil | 1977 |
Photoelectron spectroscopy of carbonyls. Ureas, uracils, and thymine 1,2.
Topics: Photochemistry; Spectrum Analysis; Thymine; Uracil; Urea | 1976 |
Interactions of nucleic acid bases with catechol: UV studies.
Topics: Adenine; Catechols; Chemical Phenomena; Chemistry; Cytosine; Spectrophotometry, Ultraviolet; Temperature; Thermodynamics; Thymine; Uracil | 1976 |
Utilization of exogenous pyrimidines as a source of nitrogen by cells of the yeast Rhodotorula glutinis.
Topics: Aminohydrolases; Ammonia; Ammonium Sulfate; Carbon Dioxide; Cell-Free System; Cytosine; Mitosporic Fungi; Nitrogen; Oxidoreductases; Pyrimidines; Rhodotorula; Thymine; Uracil | 1976 |
[Ionization potentials of nucleic acid nitrogenous bases].
Topics: Adenine; Cytosine; Guanine; Ions; Methylation; Thymine; Uracil | 1976 |
Interactions of adenine, thymine, and uracil with epinephrine: UV studies.
Topics: Adenine; Chemical Phenomena; Chemistry; Cytosine; Epinephrine; Spectrophotometry, Ultraviolet; Thymine; Uracil | 1976 |
Preparation and stereoconfigurations of heterodimers of pyrimidines.
Topics: Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Pyrimidine Dimers; Thymine; Uracil | 1976 |
Synthesis of substituted 5-fluoro-5,6-dihydropyrimidines.
Topics: Fluorine; Mass Spectrometry; Methods; Pyrimidinones; Thymine; Uracil | 1975 |
Characterization of nucleoside transport in hymenolepidid cestodes.
Topics: Adenine; Adenosine; Animals; Binding, Competitive; Biological Transport, Active; Cestoda; Cricetinae; Deoxyadenosines; Guanosine; Hymenolepis; Hypoxanthines; Kinetics; Male; Mice; Nucleosides; Rats; Stimulation, Chemical; Thymidine; Thymine; Uracil; Uridine | 1975 |
Sensitization of thymine and uracil to ionizing radiation by p-nitroacetophenone.
Topics: Acetophenones; Cobalt Radioisotopes; Gamma Rays; Nitro Compounds; Radiation Effects; Radiation-Sensitizing Agents; Thymine; Uracil | 1975 |
On the radiation chemistry of some pyrimidine-electron adducts: reaction of pyrimidine negative ions with t-butanol radicals.
Topics: Butanols; Electrons; Pulse Radiolysis; Pyrimidines; Thymidine Monophosphate; Thymine; Uracil | 1976 |
Radiation-induced binding of some protein and nucleic acid constituents with macromolecular components in cell systems.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Cell Line; Cobalt Radioisotopes; Cysteine; Cystine; Cytosine; Dose-Response Relationship, Radiation; Escherichia coli; Gamma Rays; Histidine; Leukemia, Lymphoid; Macromolecular Substances; Methionine; Mice; Phenylalanine; Protein Binding; Purines; Pyrimidines; Radiation Effects; Sulfur Radioisotopes; Thymine; Tritium; Tryptophan; Tyrosine; Uracil | 1975 |
DNA synthesis - dependent cell division of Escherichia coli 15 TAU after arginine and uracil starvation.
Topics: Arginine; Cell Count; Cell Division; Colorimetry; DNA Replication; DNA, Bacterial; Escherichia coli; Mutation; Nalidixic Acid; Oxolinic Acid; Thymine; Time Factors; Uracil | 1975 |
Dose dependence of the excision of ultraviolet-induced pyrimidine dimers from nuclear deoxyribonucleic acids of haploid and diploid Saccharomyces cerevisiae.
Topics: Centrifugation, Density Gradient; Chromatography; Culture Media; Diploidy; DNA; Dose-Response Relationship, Radiation; Haploidy; Pyrimidines; Radiation Effects; Saccharomyces cerevisiae; Sodium Chloride; Thymine; Ultraviolet Rays; Uracil | 1975 |
Repair of heat injury in thymine auxotrophs of Escherichia coli.
Topics: Arginine; Culture Media; DNA Repair; Escherichia coli; Hot Temperature; Mutation; RNA, Bacterial; Species Specificity; Thymine; Uracil | 1975 |
Multiplicity reactivation of 5-iodouracil-substituted, nonviable bacteriophage T4td8.
Topics: Coliphages; Culture Media; Escherichia coli; Mutation; Thymine; Uracil; Virus Replication | 1975 |
Energy transfer in fluorescent derivatives of uracil and thymine;.
Topics: Dansyl Compounds; Energy Transfer; Oxadiazoles; Spectrometry, Fluorescence; Thymine; Uracil | 1975 |
[Stability series of nitrogenous base pairs of nucleic acids].
Topics: Adenine; Cytosine; Guanosine; Thymine; Uracil | 1975 |
[The antiblastomatous activity of 9-methyladenine, 1-methyluracil and 1-methylthymine].
Topics: Adenine; Animals; Antimetabolites; Antineoplastic Agents; Mice; Neoplasms, Experimental; Rats; Thymine; Uracil | 1975 |
Studies on thymine and uracil triplet excited state in acetonitrile and water.
Topics: Acetonitriles; Chemical Phenomena; Chemistry; Kinetics; Spectrum Analysis; Thermodynamics; Thymine; Uracil; Water | 1975 |
[Action of heliomycin on the incorporation of labelled protein precursors and nucleic acid in Staphylococcus aureus cells].
Topics: Anti-Bacterial Agents; Carbon Radioisotopes; Depression, Chemical; DNA, Bacterial; Dose-Response Relationship, Drug; Lactones; Leucine; Protein Precursors; RNA, Bacterial; Staphylococcus aureus; Thymine; Time Factors; Uracil | 1975 |
Gas-liquid chromatographic analysis of trimethylsilyl derivatives of pyrimidine and purine bases and nucleosides.
Topics: Adenine; Chromatography, Gas; Chromatography, Liquid; Cytosine; Purine Nucleosides; Pyrimidine Nucleosides; Thymine; Trimethylsilyl Compounds; Uracil | 1976 |
On the possibility of excimer state formation in homodimers of the pyrimidine bases.
Topics: Binding Sites; Calorimetry; Cytosine; Molecular Conformation; Potentiometry; Thermodynamics; Thymine; Uracil | 1976 |
DNA sequence determinants for binding of the Escherichia coli catabolite gene activator protein.
Topics: 5-Methylcytosine; Base Sequence; Cyclic AMP Receptor Protein; Cytosine; DNA, Bacterial; Escherichia coli; Methylation; Molecular Sequence Data; Mutation; Substrate Specificity; Thermodynamics; Thymine; Uracil | 1992 |
Electron transfer from nucleobase electron adducts to 5-bromouracil. Is guanine an ultimate sink for the electron in irradiated DNA?
Topics: Adenine; Bromouracil; Cytosine; DNA; Electrons; Guanine; Hydrogen-Ion Concentration; Pulse Radiolysis; Thymidine; Thymine; Uracil | 1992 |
The biosynthetic origin of the pyridone ring of efrotomycin.
Topics: Anti-Bacterial Agents; Fermentation; Molecular Structure; Mutagenesis; Nocardia; Oxidation-Reduction; Pyridones; Thymidine; Thymine; Uracil | 1991 |
Screening for defects of dihydropyrimidine degradation by analysis of amino acids in urine before and after acid hydrolysis.
Topics: Amidohydrolases; Amino Acids; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Hydrogen-Ion Concentration; Hydrolysis; Male; Oxidoreductases; Pyrimidines; Thymine; Uracil | 1992 |
Transfection of heteroduplexes containing uracil.guanine or thymine.guanine mispairs into plant cells.
Topics: Base Composition; Base Sequence; DNA, Viral; Escherichia coli; Guanine; Molecular Sequence Data; Mosaic Viruses; Nicotiana; Nucleic Acid Heteroduplexes; Oligodeoxyribonucleotides; Plants, Toxic; Plasmids; Protoplasts; Restriction Mapping; Templates, Genetic; Thymine; Transfection; Uracil | 1992 |
Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex.
Topics: Base Sequence; Binding Sites; DNA-Binding Proteins; Fungal Proteins; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Potassium Permanganate; Protein Kinases; Saccharomyces cerevisiae Proteins; Thymine; Transcription Factors; Uracil | 1992 |
Multiple mutant of Escherichia coli synthesizing virtually thymineless DNA during limited growth.
Topics: DNA Glycosylases; DNA Repair; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Genes, Suppressor; Genotype; Kinetics; Mutation; N-Glycosyl Hydrolases; Species Specificity; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Thymine; Tritium; Uracil; Uracil-DNA Glycosidase | 1992 |
SO.(4-)-induced oxidation of 1,3,6-trimethyluracil and 1,3,5-trimethyluracil (1,3-dimethylthymine) by potassium peroxodisulphate in aqueous solution: an interesting contrast.
Topics: Cobalt Radioisotopes; Gamma Rays; Oxidation-Reduction; Potassium; Potassium Compounds; Solutions; Sulfates; Thymine; Uracil; Water | 1991 |
Long-range hole migration in irradiated crystals of nucleic acid bases. An EPR study.
Topics: Crystallization; Cytosine; Electron Spin Resonance Spectroscopy; Energy Metabolism; Guanine; Thymine; Uracil | 1991 |
The determination of absolute electron affinities of the purines and pyrimidines in DNA and RNA from reversible reduction potentials.
Topics: Adenine; Cytosine; DNA; Guanine; Potentiometry; Purines; Pyrimidines; RNA; Thymine; Uracil | 1991 |
Purification and properties of the uracil DNA glycosylase from Bloom's syndrome.
Topics: Black People; Bloom Syndrome; DNA Glycosylases; Enzyme Stability; Fibroblasts; Humans; Isoelectric Point; Isoenzymes; Jews; Kinetics; N-Glycosyl Hydrolases; Polynucleotides; Thymine; United States; Uracil; Uracil-DNA Glycosidase | 1991 |
Purine metabolites and pyrimidine bases in cerebrospinal fluid of children with simple febrile seizures.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Child, Preschool; Cytosine; Female; Guanine; Guanosine; Humans; Hypoxanthine; Hypoxanthines; Infant; Inosine; Inosine Monophosphate; Male; Purines; Pyrimidine Nucleosides; Seizures, Febrile; Thymine; Uracil; Uric Acid; Xanthine; Xanthines | 1991 |
Simple method for the quantitative analysis of dihydropyrimidines and N-carbamyl-beta-amino acids in urine.
Topics: Amidohydrolases; Amino Acids; beta-Alanine; Chromatography, Ion Exchange; Humans; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Thymine; Uracil | 1991 |
Dihydropyrimidine dehydrogenase deficiency in a Hutterite newborn.
Topics: Alberta; Consanguinity; Dihydrouracil Dehydrogenase (NADP); Ethnicity; Humans; Infant, Newborn; Male; Oxidoreductases; Purine-Pyrimidine Metabolism, Inborn Errors; T-Lymphocytes; Thymine; Uracil | 1991 |
Experimental and theoretical study of energetics of complex formation between nucleic acid bases and the bases with amide group.
Topics: Acrylamide; Acrylamides; Amino Acid Sequence; Base Composition; Mass Spectrometry; Molecular Sequence Data; Nucleic Acids; Thermodynamics; Thymine; Uracil | 1991 |
High-performance liquid chromatographic analysis of 5-ethylpyrimidines and 5-methylpyrimidines in plasma.
Topics: Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Deoxyuridine; Humans; Liver; Rats; Thymidine; Thymine; Uracil | 1991 |
Inactivation of dihydropyrimidine dehydrogenase by 5-iodouracil.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Liver; Mass Spectrometry; Molecular Sequence Data; NADP; Oxidoreductases; Peptide Mapping; Substrate Specificity; Thymine; Trypsin; Uracil | 1991 |
The first prenatal diagnosis of dihydropyrimidine dehydrogenase deficiency.
Topics: Amniotic Fluid; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Metabolism, Inborn Errors; Oxidoreductases; Pregnancy; Prenatal Diagnosis; Thymine; Uracil | 1991 |
Diagrammatic representation of the distribution of DNA bases and its applications.
Topics: Adenine; Animals; Bacteria; Base Composition; Biological Evolution; Codon; Cytosine; DNA; Genetic Variation; Guanine; Humans; Linear Models; Mathematics; Plants; RNA, Messenger; Thymine; Uracil | 1991 |
Chromatographic behaviour of cyclodextrin complexes of nucleotides, nucleosides and their bases.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Chromatography, Liquid; Cyclodextrins; Nucleosides; Nucleotides; Thymidine; Thymine; Uracil; Uridine | 1990 |
The identification and quantitation of alkylated nucleobases by high-performance liquid chromatography with UV photodiode array detection.
Topics: Adenine; Alkylation; Chromatography, High Pressure Liquid; Guanine; Reference Standards; Spectrophotometry, Ultraviolet; Thymine; Uracil | 1990 |
Transients of uracil and thymine derivatives and the quantum yields of electron ejection and intersystem crossing upon 20 ns photolysis at 248 nm.
Topics: Photolysis; Thymine; Ultraviolet Rays; Uracil | 1990 |
Characterization of photo-induced pyrimidine cyclobutane dimers by laser desorption Fourier transform mass spectrometry.
Topics: Cyclobutanes; Fourier Analysis; Lasers; Mass Spectrometry; Photochemistry; Pyrimidine Dimers; Thymine; Ultraviolet Rays; Uracil | 1990 |
Hydration of uracil and thymine methylderivatives: a Monte Carlo simulation.
Topics: Algorithms; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Methylation; Monte Carlo Method; Thymine; Uracil; Water | 1990 |
Vacuum ultraviolet circular dichroism as an indicator of helical handedness in nucleic acids.
Topics: Adenine; Circular Dichroism; Cytosine; DNA; Guanine; Nucleic Acid Conformation; RNA; Spectrophotometry, Ultraviolet; Thymine; Uracil | 1986 |
CD of homopolymer DNA-RNA hybrid duplexes and triplexes containing A-T or A-U base pairs.
Topics: Adenine; Base Composition; Circular Dichroism; DNA; Nucleic Acid Conformation; Polynucleotides; RNA; Structure-Activity Relationship; Thymine; Uracil | 1986 |
Methylation of thymine and uracil with free methyl cations formed due to beta-decay of tritiated methane: possible implication in mutagenesis and carcinogenesis.
Topics: Alkylating Agents; Carcinogens; Cations; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Methane; Methylation; Molecular Structure; Mutagens; Thymine; Tritium; Uracil | 1989 |
Template-primer activity of 5-(hydroxymethyl)uracil-containing DNA for prokaryotic and eukaryotic DNA and RNA polymerases.
Topics: Bacillus subtilis; Bacteriophages; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; DNA, Viral; Escherichia coli; Humans; Leukemia; Micrococcus; Pentoxyl; Templates, Genetic; Thymine; Transcription, Genetic; Tumor Cells, Cultured; Uracil | 1989 |
The SO4- -induced oxidation of 1,3,6-trimethyluracil and 1,3-dimethylthymine by potassium peroxodisulphate and oxygen in aqueous solution: an interesting contrast.
Topics: Catalysis; DNA; Free Radicals; Oxidation-Reduction; Potassium; Potassium Compounds; Protons; Sulfates; Thymine; Uracil | 1989 |
Oxidation of pyrimidine bases and their derivatives by sodium peroxodisulfate.
Topics: Adenine; Oxidation-Reduction; Sodium; Sodium Compounds; Sulfates; Sulfuric Acids; Thymine; Uracil | 1989 |
Comparative study of thymine and uracil metabolism in healthy persons and in a patient with dihydropyrimidine dehydrogenase deficiency.
Topics: Adult; Child; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Infant; Male; Metabolic Clearance Rate; Oxidoreductases; Thymine; Uracil | 1989 |
A screening method for dihydropyrimidine dehydrogenase deficiency with colorimetric detection of urinary uracil.
Topics: Child; Colorimetry; Dihydrouracil Dehydrogenase (NADP); Humans; Oxidoreductases; Thymine; Uracil | 1989 |
C-H ... O hydrogen bonding in solutions of methylated nucleic acid base analogs as revealed by NMR.
Topics: Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Structure; Thermodynamics; Thymine; Uracil | 1989 |
Electrical conduction in some nucleic acid base complexes with acridine orange dye: study of localized levels.
Topics: Acridine Orange; Adenine; Electric Conductivity; Guanine; Models, Chemical; Nucleic Acids; Semiconductors; Thymine; Uracil | 1989 |
Effects of N1,N3-diallyluracil and N1,N3-diallylthymine on hepatic drug-metabolizing enzymes of mice.
Topics: Animals; Injections, Intraventricular; Liver; Male; Mice; Mixed Function Oxygenases; Phenobarbital; Sleep; Thymine; Time Factors; Uracil | 1989 |
The specificity of pyrimidine nucleoside transport and metabolism by rat jejunum in vitro.
Topics: Animals; Biological Transport, Active; Deoxyuridine; Intestinal Mucosa; Jejunum; Male; Pyrimidine Nucleosides; Rats; Rats, Inbred Strains; Thymidine; Thymine; Uracil; Uridine | 1989 |
Thermodynamics of some nucleic acid bases and nucleosides in water, and their transfer to aqueous glucose and sucrose solutions at 298.15 K.
Topics: Adenine; Cytosine; Glucose; Nucleosides; Sucrose; Thermodynamics; Thymine; Uracil; Water | 1989 |
Sonolysis, radiolysis, and hydrogen peroxide photolysis of pyrimidine derivatives in aqueous solutions: a spin-trapping study.
Topics: Benzenesulfonates; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen Peroxide; Nitroso Compounds; Orotic Acid; Photolysis; Pyrimidines; Radiation Effects; Solutions; Spin Labels; Thymine; Ultrasonics; Uracil; Water | 1988 |
Analysis of the sequence-specific interactions between Cro repressor and operator DNA by systematic base substitution experiments.
Topics: Amino Acid Sequence; DNA; Molecular Sequence Data; Mutation; Operator Regions, Genetic; Repressor Proteins; Thymine; Transcription Factors; Uracil | 1989 |
Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity.
Topics: Adult; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; Fluorouracil; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Thymine; Uracil | 1985 |
The reactions of the hydroxymethyl radical with 1,3-dimethyluracil and 1,3-dimethylthymine.
Topics: Chromatography, Gas; DNA; Free Radicals; Hydroxides; Hydroxyl Radical; Radiochemistry; Thymine; Uracil | 1986 |
Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium.
Topics: Aflatoxin B1; Aflatoxins; Aminopterin; Aspartic Acid; Bacillus megaterium; DNA, Bacterial; Drug Synergism; Folic Acid; Orotic Acid; Thymine; Uracil; Uridine Monophosphate | 1986 |
Production of 5-formyluracil from thymine in an in vitro active oxygen-generating system.
Topics: Ascorbic Acid; Chromatography, High Pressure Liquid; Edetic Acid; Ferrous Compounds; Gas Chromatography-Mass Spectrometry; Oxidation-Reduction; Oxygen; Spectrophotometry, Ultraviolet; Thymine; Uracil | 1987 |
Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.
Topics: Animals; Barbiturates; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NAD+); Fluorouracil; Kinetics; Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Pyridines; Pyrimidines; Rats; Sarcoma 180; Thymine; Uracil | 1987 |
The significance of 3H-thymidine degradation in cell culture experiments with special reference to rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biological Transport; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Thymidine; Thymidine Phosphorylase; Thymine; Uracil | 1988 |
Isocratic high-performance liquid chromatographic method for studying the metabolism of blood plasma pyrimidine nucleosides and bases: concentration and radioactivity measurements.
Topics: Animals; Chromatography, High Pressure Liquid; Cytosine; Dogs; Female; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Pyrimidine Nucleosides; Rabbits; Rats; Rats, Inbred Strains; Thymine; Uracil | 1988 |
Base sequence effects in double helical DNA. I. Potential energy estimates of local base morphology.
Topics: Base Composition; Base Sequence; Cytosine; DNA; Guanine; Hypoxanthine; Hypoxanthines; Methylation; Molecular Sequence Data; Nucleic Acid Conformation; Stereoisomerism; Thermodynamics; Thymine; Uracil | 1987 |
Repair of thymine.guanine and uracil.guanine mismatched base-pairs in bacteriophage M13mp18 DNA heteroduplexes.
Topics: Bacteriophages; Base Composition; DNA Repair; DNA, Viral; Escherichia coli; Guanine; Methylation; Nucleic Acid Heteroduplexes; Thymine; Uracil | 1987 |
Pulse radiolytic studies of radicals produced from methylated uracils via oxidation by SO4..
Topics: Oxidation-Reduction; Pulse Radiolysis; Sulfates; Thymine; Uracil | 1988 |
Potentiating effects of N1,N3-diallyluracil, N1,N3-diallylthymine and N1,N3-diallyl-6-methyluracil on pentobarbital-induced sleep and diazepam-induced motor incoordination.
Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; In Vitro Techniques; Lethal Dose 50; Mice; Pentobarbital; Psychomotor Performance; Sleep; Thymine; Uracil | 1987 |
Radioprotection of pyrimidines by oxygen and sensitization by phosphate: a feature of their electron adducts.
Topics: Oxygen; Phosphates; Pyrimidines; Radiation-Protective Agents; Radiation-Sensitizing Agents; Thymine; Uracil | 1987 |
DNA cytosine methylation and heat-induced deamination.
Topics: 5-Methylcytosine; Cytosine; Deamination; DNA, Bacterial; DNA, Single-Stranded; Escherichia coli; Hot Temperature; Humans; Kinetics; Methylation; Thymine; Uracil | 1986 |
Degradation of the pyrimidine bases uracil and thymine by Escherichia coli B.
Topics: Biotransformation; Chromatography, Thin Layer; Escherichia coli; Oxidation-Reduction; Thymine; Uracil | 1987 |
Giardia lamblia: uptake of pyrimidine nucleosides.
Topics: Animals; Biological Transport; Cytidine; Cytosine; Ethylmaleimide; Giardia; Iodoacetates; Iodoacetic Acid; Kinetics; Thymidine; Thymine; Uracil; Uridine | 1987 |
Dihydropyrimidine dehydrogenase deficiency. Neurological aspects.
Topics: Adult; Child; Child, Preschool; Dihydrouracil Dehydrogenase (NADP); Epilepsy; Female; Fibroblasts; Humans; Male; Middle Aged; Oxidoreductases; Pedigree; Thymine; Uracil | 1987 |
Absorption of 5-fluorouracil and related pyrimidines in rat small intestine.
Topics: Animals; Biological Transport, Active; Chromatography, High Pressure Liquid; Fluorouracil; Galactose; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Perfusion; Rats; Rats, Inbred Strains; Thymine; Uracil; Water | 1987 |
Guanine is a growth factor for Legionella species.
Topics: Adenine; Culture Media; Cytosine; Growth Substances; Guanine; Hydrogen-Ion Concentration; Hypoxanthine; Hypoxanthines; Legionella; Nucleosides; Nucleotides; Thymine; Uracil; Xanthine; Xanthines | 1986 |
Uric acid protection of nucleobases from ozone-induced degradation.
Topics: Antioxidants; Chromatography, Paper; Guanine; Ozone; Purines; Pyrimidines; Thymine; Uracil; Uric Acid | 1986 |
Dihydrothymine dehydrogenase deficiency in a family, leading to elevated levels of uracil and thymine.
Topics: Child; Chromatography, Gas; Dihydrouracil Dehydrogenase (NAD+); Female; Fibroblasts; Humans; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Purine-Pyrimidine Metabolism, Inborn Errors; Reference Values; Thymine; Uracil | 1986 |
In vitro degradation of pyrimidine bases: studies of rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1986 |
Thymineless mutagenesis in bacteria.
Topics: Base Composition; Base Sequence; DNA Glycosylases; Escherichia coli; Histidine; Kinetics; Lac Operon; Mutation; N-Glycosyl Hydrolases; Thymine; Uracil; Uracil-DNA Glycosidase | 1985 |
Quantitative determination of the 5-(hydroxymethyl)uracil moiety in the DNA of gamma-irradiated cells.
Topics: Acetylation; Chromatography, High Pressure Liquid; DNA; DNA, Bacterial; DNA, Neoplasm; Escherichia coli; Gamma Rays; HeLa Cells; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pentoxyl; Thymine; Uracil | 1985 |
Dihydropyrimidine dehydrogenase deficiency leading to thymine-uraciluria. An inborn error of pyrimidine metabolism.
Topics: Child, Preschool; Dihydrouracil Dehydrogenase (NADP); Humans; Male; Oxidoreductases; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 1985 |
Dihydropyrimidine dehydrogenase deficiency--a further case.
Topics: Dihydrouracil Dehydrogenase (NADP); Humans; Infant; Male; Oxidoreductases; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 1985 |
Increased beta-aminoisobutyric acid in rat liver with 6-azauracil and its enantiomer.
Topics: Aminoisobutyric Acids; Animals; beta-Alanine; Liver; Male; Rats; Rats, Inbred Strains; Stereoisomerism; Thymine; Uracil | 1985 |
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
Topics: Animals; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Fluorouracil; Leukemia P388; Leukemia, Experimental; Liver; Metabolic Clearance Rate; Mice; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil | 1986 |
Hydrogen-bonding preferences in 2,6-diaminopurine: uracil (thymine) and 8-methyl adenine:uracil (thymine) complexes.
Topics: Adenine; Adenosine; Hydrogen Bonding; Nucleic Acid Conformation; Structure-Activity Relationship; Thymine; Uracil | 1986 |
Modulation of 5-fluorouracil catabolism in isolated rat hepatocytes with enhancement of 5-fluorouracil glucuronide formation.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Fluorouracil; In Vitro Techniques; Kinetics; Liver; Male; Pyrimidine Nucleosides; Rats; Rats, Inbred Strains; Thymine; Tritium; Uracil | 1985 |
Formation of radiation-induced cross-links between thymine and tyrosine: possible model for cross-linking of DNA and proteins by ionizing radiation.
Topics: Chromatography, Gas; DNA; Gas Chromatography-Mass Spectrometry; Models, Biological; Proteins; Thymidine; Thymidine Monophosphate; Thymine; Tyrosine; Uracil | 1985 |
Clinical pharmacology of 5-iodo-2'-deoxyuridine and 5-iodouracil and endogenous pyrimidine modulation.
Topics: Chromatography, High Pressure Liquid; Deoxyuridine; Humans; Idoxuridine; Infusions, Parenteral; Neoplasms; Thymine; Uracil; Uridine | 1985 |
Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Rats; Rats, Inbred Strains; Thymidine; Thymine; Uracil; Uridine | 1985 |
Inhibition of uracil-DNA glycosylase increases SCEs in BrdU-treated and visible light-irradiated cells.
Topics: Allium; Bromodeoxyuridine; DNA Glycosylases; DNA Repair; Interphase; Kinetics; Light; N-Glycosyl Hydrolases; Plants; Sister Chromatid Exchange; Thymine; Uracil; Uracil-DNA Glycosidase | 1985 |
Reaction of nucleic acids bases and their derivatives with peroxodisulfate ion.
Topics: Caffeine; Chemical Phenomena; Chemistry; Indicators and Reagents; Peroxides; Sodium Compounds; Structure-Activity Relationship; Sulfates; Sulfuric Acids; Thymine; Uracil | 1985 |
Action of bleomycin on DNA and RNA.
Topics: Adenine Nucleotides; Aldehydes; Antibiotics, Antineoplastic; Base Sequence; Bleomycin; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Cytosine Nucleotides; Dithiothreitol; DNA; DNA, Bacterial; Flavin-Adenine Dinucleotide; Guanine Nucleotides; Inosine Nucleotides; Mercaptoethanol; Oxidation-Reduction; Poly A-U; Polynucleotides; RNA; RNA, Viral; Thymine; Thymine Nucleotides; Tritium; Uracil | 1972 |
[Molecular origin of the effects of light on nucleic acid metabolism].
Topics: Animals; Bacteria; Bacteriophages; Cytosine; DNA; Humans; Methylene Blue; Mice; Nucleic Acid Renaturation; Nucleic Acids; Orotic Acid; Photochemistry; Protein Conformation; Pyrimidines; Quaternary Ammonium Compounds; Radiation Effects; RNA; Skin Neoplasms; Thioxanthenes; Thymine; Ultraviolet Rays; Uracil; Viruses | 1974 |
Investigations on the mode of action of Triclosan, a broad spectrum antimicrobial agent.
Topics: Anti-Bacterial Agents; Bacteria; Carbon Radioisotopes; Cell-Free System; DNA-Directed RNA Polymerases; DNA, Bacterial; Escherichia coli; Phenylalanine; RNA, Bacterial; Thymine; Uracil | 1974 |
The use of ficoll gradient centrifugation to produce synchronous mouse lymphoma cells.
Topics: Animals; Cell Division; Centrifugation, Density Gradient; Iodine Isotopes; Lymphoma; Methods; Mice; Polysaccharides; Staining and Labeling; Thymine; Time Factors; Tritium; Uracil; Uracil Nucleotides | 1969 |
The formation of pyrimidine dimers in the DNA of fungi and bacteria.
Topics: Bacillus subtilis; Basidiomycota; Carbon Isotopes; Cytosine; DNA; DNA Repair; Escherichia coli; Micrococcus; Pyrimidines; Radiation Effects; Saccharomyces cerevisiae; Species Specificity; Thymine; Ultraviolet Rays; Uracil | 1973 |
The labeling of nucleic acids by radioactive precursors in the blue-green algae Anacystis nidulans and Synechocystis aquatilis Sanv.
Topics: Carbon Radioisotopes; Chlorophyta; Cyanobacteria; Cytosine; Deoxyadenosines; DNA; Fungi; Isotope Labeling; Nucleic Acids; Radiometry; RNA; Thymidine; Thymine; Uracil | 1973 |
Effect of nalidixic acid on PBS2 bacteriophage infection of Bacillus subtilis.
Topics: Bacillus subtilis; Bacteriophages; Colorimetry; DNA, Bacterial; DNA, Viral; Hydroxyurea; Nalidixic Acid; Thymine; Time Factors; Uracil; Virus Replication | 1973 |
The occurrence of two types of synthesis of deoxyribonucleic acid during normal growth in Bacillus subtilis.
Topics: Azo Compounds; Bacillus subtilis; Caffeine; Carbon Radioisotopes; Centrifugation, Density Gradient; DNA Replication; DNA, Bacterial; Phenols; Thymidine; Thymine; Tritium; Uracil; Uridine | 1973 |
Synthesis of the unusual DNA of Bacillus subtilis bacteriophage SP-15.
Topics: Bacillus subtilis; Bacteriophages; Carbon Radioisotopes; Centrifugation, Density Gradient; Cesium; DNA, Bacterial; DNA, Viral; Hydrolysis; Pyrimidines; Thymine; Time Factors; Tritium; Uracil | 1973 |
Transfection of Bacillus subtilis with bacteriophage H1 DNA: fate of transfecting DNA and transfection enhancement in B. subtilis uur+ and uur- strains.
Topics: Bacillus subtilis; Bacteriophages; Carbon Radioisotopes; Cell Nucleus; Centrifugation, Density Gradient; DNA Repair; DNA, Viral; Escherichia coli; Haemophilus influenzae; Micrococcus; Molecular Weight; Radiation Genetics; Thymine; Time Factors; Transformation, Genetic; Ultraviolet Rays; Uracil | 1974 |
Factors influencing the frequency of mesosomes observed in fixed and unfixed cells of Streptococcus faecalis.
Topics: Autolysis; Bacterial Proteins; Carbon Radioisotopes; Cell Wall; Cytological Techniques; DNA, Bacterial; Enterococcus faecalis; Freeze Etching; Glutaral; Glycerol; Leucine; Microscopy, Electron; Microtomy; Organoids; Osmium; Oxides; RNA, Bacterial; Thymine; Uracil | 1974 |
Minicells of Bacillus subtilis. A unique system for transport studies.
Topics: Amino Acids; Bacillus subtilis; Biological Transport; Biological Transport, Active; Carbon Radioisotopes; Kinetics; Mutation; Organoids; Proline; Spectrophotometry; Thymine; Time Factors; Tritium; Ultrasonics; Uracil | 1974 |
GLC determination of fluorouracil.
Topics: Aniline Compounds; Bacillus subtilis; Biological Assay; Chromatography, Gas; Chromatography, Ion Exchange; Escherichia coli; Fluorouracil; Methods; Spectrophotometry, Ultraviolet; Thymine; Uracil | 1974 |
Mutants of Bacillus subtilis bacteriophage phi e defective in dTTP-dUTP nucleotidohydrolase.
Topics: Bacillus subtilis; Bacteriophages; Defective Viruses; DNA, Viral; Mutation; Pyrophosphatases; Temperature; Thymine; Thymine Nucleotides; Uracil; Uracil Nucleotides; Virus Replication | 1974 |
Bacteriophage PBS2-induced deoxycytidine triphosphate deaminase in Bacillus subtilis.
Topics: Aminohydrolases; Bacillus subtilis; Bacteriophages; Cell-Free System; Chloramphenicol; Chromatography, Paper; Dactinomycin; Deoxycytidine; DNA Viruses; DNA, Viral; Enzyme Induction; Mutation; Nucleotide Deaminases; Rifampin; Thymine; Tritium; Uracil | 1974 |
Pyrimidine-sensitive drosophila wing mutants: withered (whd), tilt (tt) and dumpy (dp).
Topics: Alanine; Animals; Chromosomes; Culture Media; Drosophila melanogaster; Female; Genes, Lethal; Male; Mutation; Phenotype; Phosphotransferases; Pyrimidines; Suppression, Genetic; Thymidine; Thymine; Uracil; Uridine; Wings, Animal | 1974 |
[Investigations on the mechanism of induction of lysogenic bacteria. IX. The temperature dependence of induction by thymine deficiency and mitomycin C].
Topics: Coliphages; Escherichia coli; Floxuridine; In Vitro Techniques; Mitomycins; Mutation; Temperature; Thymine; Uracil | 1966 |
[Action of highly polymerized nucleic acids and their bases on the survival of thymocytes of rats irradiated in vitro].
Topics: Adenine; Animals; Cytosine; DNA; Guanine; In Vitro Techniques; Purines; Pyrimidines; Radiation Effects; Rats; RNA; Thymine; Thymus Gland; Uracil | 1966 |
Interfering substances in the determination of poisons in autopsy material: nicotinamide, uracil and thymine.
Topics: Humans; Liver; Niacinamide; Spectrophotometry; Thymine; Uracil | 1967 |
[Effects of DNA inhibitors on the multiplication of bacteriophage Ox 174].
Topics: Coliphages; DNA; Escherichia coli; Floxuridine; Thymine; Uracil | 1967 |
Timing of enzyme synthesis during outgrowth of spores of Bacillus cereus. II. Relationship between ordered enzyme synthesis and deoxyribonucleic acid replication.
Topics: Adenine; Amino Acid Oxidoreductases; Bacillus cereus; Bromodeoxyuridine; Carbon Isotopes; Centrifugation, Density Gradient; DNA Replication; DNA, Bacterial; Enzyme Induction; Floxuridine; Glucosidases; Lyases; Mitomycins; Mutation; RNA, Messenger; Spores; Thymine; Tritium; Uracil | 1968 |
Effect of folinate on thymidine uptake by Pediococcus cerevisiae.
Topics: Aminopterin; Carbon Isotopes; Deoxyuridine; Floxuridine; Glucose; Hydrogen-Ion Concentration; Iodoacetates; Leucovorin; Methotrexate; Pediococcus; Temperature; Thymidine; Thymine; Tritium; Uracil | 1968 |
[Reciprocal modifications of nervous excitability under the effect of purine and pyrimidine bases].
Topics: Adenine; Animals; Cytosine; Guanine; Nervous System; Purines; Pyrimidines; Rats; Thymine; Uracil | 1968 |
[Comparative radiosensitivity of thymine and its (5-halo uracil) analogs in Escherichia coli].
Topics: Carbon Isotopes; DNA, Bacterial; Escherichia coli; Nitrogen; Radiation Effects; Radiation Genetics; Thymine; Uracil | 1969 |
Effect of cornin on nucleic acid synthesis during early development in sea urchin eggs.
Topics: Animals; Autoradiography; Cell Division; DNA; Echinodermata; Female; Mitosis; Ovum; RNA; Seawater; Thymidine; Thymine; Time Factors; Tissue Extracts; Uracil; Uridine | 1969 |
Inhibitory action of thymine ribonucleoside and other pyrimidine derivatives on the cleavage of 5-iodo-deoxy-uridine by mouse-liver extract.
Topics: Animals; Chromatography, Thin Layer; Deoxyribonucleosides; Depression, Chemical; Female; Floxuridine; Hydrogen-Ion Concentration; Idoxuridine; Iodine Isotopes; Kinetics; Liver; Mice; Nucleosides; Pentosyltransferases; Pyrimidines; Rats; Ribonucleosides; Thymidine; Thymine; Uracil; Uridine | 1970 |
Stoichiometry of the pyrimidine deoxyribonucleoside 2'-hydroxylase reaction and of the conversions of 5-hydroxymethyluracil to 5-formyluracil and of the latter to uracil-5-carboxylic acid.
Topics: Ammonium Sulfate; Calcium Phosphates; Carbon Dioxide; Carbon Isotopes; Carboxylic Acids; Catalase; Chromatography, DEAE-Cellulose; Chromatography, Gel; Dealkylation; Decarboxylation; Deoxyribonucleosides; Formates; Ketoglutaric Acids; Mixed Function Oxygenases; Neurospora; Neurospora crassa; Oxidation-Reduction; Pyrimidines; Succinates; Thymidine; Thymine; Uracil | 1972 |
Interrelationship between membrane protein composition and deoxyribonucleic acid synthesis in Escherichia coli.
Topics: Amino Acids; Azo Compounds; Bacterial Proteins; Carbon Isotopes; Cell Membrane; DNA, Bacterial; Electrophoresis; Escherichia coli; Floxuridine; Genetics, Microbial; Hydroxyurea; Isotope Labeling; Leucine; Mitomycins; Mutation; Nalidixic Acid; Penicillins; Sodium Dodecyl Sulfate; Temperature; Thymine; Tritium; Uracil | 1972 |
[Selective conidiogenic effect of thymine on a "serineless" mutant of Neurospora crassa].
Topics: Mutation; Neurospora; Neurospora crassa; Serine; Spores, Fungal; Thymine; Uracil | 1973 |
Effects of 5-fluoro-2'-deoxyuridine on bacterial growth. Its use for DNA labelling.
Topics: Bacillus; Bacillus cereus; Bacillus subtilis; Deoxyribonucleosides; DNA, Bacterial; Escherichia coli; Floxuridine; Micrococcus; Pseudomonas; Pseudomonas fluorescens; Thymine; Tritium; Uracil | 1973 |
Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase.
Topics: Binding Sites; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Chromatography, Gel; Electrophoresis, Disc; Formates; Hot Temperature; Ketoglutaric Acids; Kinetics; Methanol; Mixed Function Oxygenases; Neurospora crassa; Protein Denaturation; Thymine; Time Factors; Uracil | 1973 |
The influence of 5-halo substituents on the thermal depyrimidination of the glycosidic bond in 2'-deoxyuridines.
Topics: Bromodeoxyuridine; Calorimetry; Deoxyuridine; Floxuridine; Guanosine; Iodine; Molecular Conformation; Temperature; Thermodynamics; Thymidine; Thymine; Uracil | 1974 |
Radiation sensitivity of cells and base composition of DNA: an electron spin resonance study.
Topics: Adenine; Animals; Bacteria; Cytosine; DNA; DNA, Bacterial; Electron Spin Resonance Spectroscopy; Guanine; In Vitro Techniques; Radiation Effects; Ribose; RNA; Thymine; Thymus Gland; Uracil; Yeasts | 1966 |
Electron spin resonance technique for investigating reactions of free radicals with compounds of biological interest: nucleic acid constituents.
Topics: Chemical Phenomena; Chemistry; Deuterium; Electron Spin Resonance Spectroscopy; Hydrogen; Thymidine; Thymine; Uracil; Uracil Nucleotides; Uridine | 1966 |
Reaction of OH radicals with nucleic acid bases--an E.S.R. study.
Topics: Cytosine; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Nucleic Acids; Purines; Pyrimidines; Spectrum Analysis; Thymine; Uracil | 1966 |
Radical yields in some nucleic acid constituents.
Topics: Adenine; Cytosine; Electron Spin Resonance Spectroscopy; Guanine; Nucleic Acids; Thymine; Uracil | 1966 |
Irradiation of dihydropyrimidines.
Topics: Electron Spin Resonance Spectroscopy; Free Radicals; Pyrimidines; Radiation Effects; Radiochemistry; Thymine; Uracil | 1968 |
[Separation of nucleic acids by thin layer chromatography].
Topics: 1-Propanol; Adenine; Cellulose; Chromatography, Thin Layer; Cytosine; Guanine; Nucleic Acids; Perchlorates; Thymine; Uracil | 1966 |
[Study of radical stages of low-temperature radiolysis of some heteroaromatic compounds-components of nucleic acids].
Topics: Adenine; Cytosine; DNA; Electron Spin Resonance Spectroscopy; Free Radicals; Guanine; Radiochemistry; Temperature; Thymine; Uracil | 1966 |
Radicals formed by electron transfer to pyrimidine derivatives.
Topics: Chemical Phenomena; Chemistry; DNA; Electron Spin Resonance Spectroscopy; Electrons; Free Radicals; Nucleosides; Protons; Pyrimidines; Radiation Effects; Thymidine; Thymine; Uracil | 1968 |
An ESR study of short-lived radicals derived from pyrimidines in aqueous solution.
Topics: Chemical Phenomena; Chemistry; Computers; Cytosine; Electron Spin Resonance Spectroscopy; Free Radicals; Orotic Acid; Pyrimidines; Solutions; Thymine; Time Factors; Uracil; Water | 1969 |
Sequential degradation of nucleic acids. Degradation of Escherichia coli B phenylalanine transfer ribonucleic acid.
Topics: Chemical Phenomena; Chemistry; Cytosine; Escherichia coli; Guanine; Methods; Nucleosides; Nucleotides; Phenylalanine; Phosphoric Monoester Hydrolases; RNA, Bacterial; RNA, Transfer; Thymine; Time Factors; Uracil | 1969 |
Control of deoxyribonucleic acid and ribonucleic acid synthesis in pyrimidine-limited Escherichia coli.
Topics: Autoradiography; Chromatography; Chromosomes, Bacterial; DNA Replication; DNA, Bacterial; Electrophoresis; Escherichia coli; Orotic Acid; Pyrimidines; Ribosomes; RNA, Bacterial; RNA, Transfer; Silicon Dioxide; Spectrophotometry; Thymine; Tritium; Uracil | 1970 |
Nucleoside phosphorothioates.
Topics: Adenine; Alkaline Phosphatase; Cytosine; Hypoxanthines; Nucleotides; Phosphoric Monoester Hydrolases; Ribonucleases; Sulfur; Thymine; Uracil | 1970 |
Adenine complexes of thymine and uracil: electron spin resonance and thermoluminescence investigations.
Topics: Adenine; Chemical Phenomena; Chemistry; Cobalt Isotopes; Electron Spin Resonance Spectroscopy; Electrons; Free Radicals; Hot Temperature; Luminescent Measurements; Radiation; Radiation Effects; Temperature; Thymine; Uracil | 1971 |
Electron spin resonance study of radicals produced in irradiated aqueous solutions of uracil and related pyrimidines.
Topics: Barbiturates; Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Electrons; Formates; Free Radicals; Hydrogen-Ion Concentration; Nitrous Oxide; Orotic Acid; Pyrimidines; Radiation Effects; Solutions; Spectrum Analysis; Thymine; Uracil; Water | 1972 |
Transient radicals of DNA bases by pulse radiolysis. Effects of cysteine and cysteamine as radioprotectors.
Topics: Cysteamine; Cysteine; Cytosine; Electron Spin Resonance Spectroscopy; Electron Transport; Free Radicals; Helium; Hydrogen-Ion Concentration; Kinetics; Nitrogen; Nitrous Oxide; Oxygen; Purines; Pyrimidines; Radiation Effects; Radiation-Protective Agents; Radiochemistry; Solutions; Spectrum Analysis; Thymine; Uracil; Water | 1972 |
Dissociating activity of purified colicin E 2 on the isolated DNA-membrane complex of Escherichia coli.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Carbon Isotopes; Cell Count; Cell Membrane; Centrifugation, Density Gradient; Centrifugation, Zonal; Chelating Agents; Colicins; Diphosphates; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Lipids; Mutation; Nucleotides; Protein Binding; Receptors, Drug; Spheroplasts; Temperature; Thymine; Tritium; Uracil | 1972 |
Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogues: possible role of cyclic AMP.
Topics: Adenine; Caffeine; Cyclic AMP; Epinephrine; Guanine; Guanosine; Humans; Hypoxanthines; Imidazoles; Leukocytes; Movement; Purines; Pyrimidines; Reserpine; Structure-Activity Relationship; Theophylline; Thymine; Uracil; Uric Acid; Xanthines | 1972 |
Pyrimidine nucleosides of the furanose form of 2-amino-2-deoxy-D-xylose.
Topics: Acetamides; Amino Sugars; Ammonia; Anhydrides; Borohydrides; Furans; Methanol; Nucleosides; Optical Rotatory Dispersion; Periodic Acid; Thymine; Uracil; Xylose | 1971 |
MOdified nucleosides of nuclear and nucleolar low molecular weight ribonucleic acid.
Topics: Adenine; Animals; Carcinoma, Hepatocellular; Cell Nucleolus; Cell Nucleus; Chromatography, Gel; Chromatography, Thin Layer; Cytosine; Electrophoresis, Polyacrylamide Gel; Glycols; Guanine; Hypoxanthines; Liver Neoplasms; Male; Molecular Weight; Neoplasms, Experimental; Nucleosides; Rats; RNA, Neoplasm; Thymine; Uracil | 1972 |
Trapping of radicals formed in the photochemical reaction between hydrogen peroxide and some pyrimidine bases, nucleosides, nucleotides, and yeast nucleic acid.
Topics: Cytosine; DNA; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen Peroxide; Nitrogen Isotopes; Nucleosides; Nucleotides; Photochemistry; Pyrimidines; Saccharomyces cerevisiae; Thymine; Uracil | 1973 |
Pyrimidine metabolism in Acinetobacter calcoaceticus.
Topics: Alcaligenes; Carbon Radioisotopes; Cell-Free System; Centrifugation, Density Gradient; Chromatography, Paper; DNA, Bacterial; Mutation; Nucleotidases; Pentosyltransferases; Phosphoric Monoester Hydrolases; Phosphotransferases; Pyrimidine Nucleotides; RNA, Bacterial; Species Specificity; Thymidine; Thymidine Kinase; Thymine; Tritium; Uracil; Uridine | 1973 |
Structure and formation of free radicals in irradiated single crystals of nucleic acid constituents.
Topics: Adenine; Barbiturates; Bromodeoxyuridine; Crystallization; Electron Spin Resonance Spectroscopy; Free Radicals; Guanine; Idoxuridine; Molecular Conformation; Orotic Acid; Purines; Pyrimidines; Radiation Effects; Structure-Activity Relationship; Thymine; Uracil | 1973 |
Inhibitory effects of 2-thiouracil and 2-thiouracil metabolites on enzymes involved in pyrimidine nucleotide biosynthesis.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; In Vitro Techniques; Kinetics; Mice; Nucleotidyltransferases; Orotic Acid; Pentosyltransferases; Phosphotransferases; Proteins; Pyrimidines; Rats; Thiouracil; Thymidine; Thymine; Uracil; Uracil Nucleotides; Uridine | 1974 |
[Production of deficient mutants of Candida guilliermondii with methanesulfonic acid ethyl ester].
Topics: Adenine; Amino Acids; Candida; Culture Media; Esters; Genetics, Microbial; Guanine; Mutagens; Mutation; Sulfonic Acids; Thymine; Uracil; Vitamin B Complex | 1968 |
Interactions of polynucleotides and their components. II. Interaction of uracil derivatives with alkali- and alkali earth chlorides.
Topics: Calcium Chloride; Chemical Phenomena; Chemistry; Chlorides; Hydrogen-Ion Concentration; Polynucleotides; Pyrimidines; Spectrophotometry; Thymine; Ultraviolet Rays; Uracil; Uracil Nucleotides | 1968 |
Permissible base sequences for non self complementary messenger RNAs.
Topics: Adenine; Chemical Phenomena; Chemistry; Computers; Cytosine; Genetic Code; Polynucleotides; Ribosomes; RNA, Messenger; Thymine; Uracil | 1969 |
A note on in vitro inhibition of thymine degradation by some pyrimidine analogues and related products.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Depression, Chemical; Fluorouracil; In Vitro Techniques; Liver; Pyrimidines; Swine; Thymine; Uracil | 1969 |
Purification and properties of dihydrouracil dehydrogenaase from pig liver.
Topics: Acridines; Animals; Carbon Isotopes; Chromatography, Thin Layer; Hydrogen-Ion Concentration; Kinetics; Lactates; Liver; NAD; NADP; Oxidoreductases; Swine; Thymine; Uracil | 1970 |
Dihydrouracil dehydrogenase of rat liver. Separation of hydrogenase and dehydrogenase activities.
Topics: Adenosine Triphosphate; Animals; Cell Membrane; Cell Nucleus; Endoplasmic Reticulum; Glucose-6-Phosphatase; Glutamate Dehydrogenase; Glycerol; Hydrogen-Ion Concentration; Hydrogenation; Liver; Lysosomes; Magnesium; Male; Membranes; Mitochondria, Liver; NAD; NADP; Nucleotidases; Oxidoreductases; Rats; Stimulation, Chemical; Thymine; Uracil | 1971 |
Dihydrouracil dehydrogenase activity in normal, differentiating and regnerating liver and in hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Cell Count; Cell Division; Female; Liver; Liver Neoplasms; Liver Regeneration; Male; NADP; Neoplasm Transplantation; Neoplasms, Experimental; Oxidoreductases; Rats; Spectrophotometry; Thymine; Transplantation, Homologous; Uracil | 1971 |
Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus.
Topics: Amobarbital; Bacillus cereus; Barbiturates; Bemegride; Biological Transport; Carbon Isotopes; Carboxylic Acids; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Chlorpromazine; Glutethimide; Hexobarbital; Hydantoins; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Orotic Acid; Pentobarbital; Phenobarbital; Phenytoin; Primidone; Solubility; Succinimides; Thiopental; Thymine; Trimethadione; Tromethamine; Uracil; Urea | 1970 |
Molecular interaction of L-tryptophan with bases, ribonucleosides and DNA.
Topics: Adenine; Circular Dichroism; Cytosine; DNA; Guanosine; Magnetic Resonance Spectroscopy; Nucleosides; Radiation Effects; Radiation-Protective Agents; Ribonucleosides; Solubility; Spectrum Analysis; Thymine; Tryptophan; Ultraviolet Rays; Uracil; Viscosity | 1971 |
High protective action against gamma radiation damage, by a tryptophan-ethanol mixture.
Topics: Adenine; Cytosine; DNA; Ethanol; Guanine; Radiation; Radiation Effects; Radiation-Protective Agents; Seeds; Thymine; Tryptophan; Uracil | 1972 |
[Photochemistry of 5-iodouracil in aqueous oxygenated solution in presence of primary and secondary alcohols].
Topics: 1-Propanol; Acetaldehyde; Acetone; Aldehydes; Ethanol; Glycols; Hydrogen-Ion Concentration; Oxygen; Photolysis; Solutions; Thymine; Ultraviolet Rays; Uracil | 1972 |
Double-stranded ribonucleic acid from maize rough dwarf virus.
Topics: Centrifugation, Density Gradient; Chromatography, Thin Layer; Cytosine; Guanine; Hot Temperature; Hydrochloric Acid; Hydrolysis; Nucleic Acid Denaturation; Perchlorates; Plant Viruses; Ribonucleases; RNA, Viral; Sodium Dodecyl Sulfate; Spectrophotometry, Ultraviolet; Thymine; Uracil; Zea mays | 1972 |
Purine and pyrimidine absorption by the gut of the chiton, Cryptochiton stelleri.
Topics: Adenine; Aerobiosis; Anaerobiosis; Animals; Biological Transport, Active; Cytosine; Female; Guanine; Hypoxanthines; Intestinal Absorption; Male; Mollusca; Purines; Thymine; Uracil; Uric Acid | 1972 |
Photosensitized cycloadditions to 1,3-dimethyl-6-azauracil and 1,3-dimethyl-6-azathymine. An imine linkage unusually reactive toward photocycloaddition.
Topics: Aza Compounds; Cyclization; Magnetic Resonance Spectroscopy; Mass Spectrometry; Photochemistry; Radiation Effects; Spectrophotometry, Infrared; Thymine; Ultraviolet Rays; Uracil | 1974 |
Conformation of nucleosides. Dipole moments of pyrimidine nucleosides.
Topics: Acetals; Arabinose; Bromouracil; Chemical Phenomena; Chemistry, Physical; Circular Dichroism; Cytidine; Deoxyribonucleosides; Ethers, Cyclic; Furans; Glycosides; Light; Mathematics; Molecular Conformation; Optics and Photonics; Pyrimidine Nucleosides; Ribonucleosides; Thiouracil; Thiouridine; Thymine; Uracil; Uridine | 1974 |
Photochemical addition of amino acids to thymine.
Topics: Amino Acids; Binding Sites; Carbon Radioisotopes; Chromatography, Ion Exchange; Kinetics; Photochemistry; Radiation Effects; Thymine; Time Factors; Ultraviolet Rays; Uracil | 1974 |
Photochemical addition of glutathione to uracil and thymine.
Topics: Acetates; Cysteine; Energy Transfer; Glutathione; Hot Temperature; Photochemistry; Thymine; Ultraviolet Rays; Uracil; Zinc | 1974 |
Recovery of pyrimidine-base derivatives in gas chromatography.
Topics: Adsorption; Carbon Radioisotopes; Chromatography, Gas; Evaluation Studies as Topic; Methane; Methods; Silicon; Spectrophotometry; Spectrophotometry, Ultraviolet; Temperature; Thymine; Time Factors; Uracil | 1974 |
Stereochemically controlled photoreactions between two thymine rings.
Topics: Bridged-Ring Compounds; Cyclization; Photochemistry; Stereoisomerism; Thymine; Ultraviolet Rays; Uracil | 1974 |
The analysis of purine and pyrimidine bases and their nucleosides by high-pressure liquid chromatography.
Topics: Base Sequence; Chromatography; Cytosine; Guanine; Humans; Hypoxanthines; Ion Exchange Resins; Pressure; Purine Nucleosides; Purines; Pyrimidine Nucleosides; Pyrimidines; Temperature; Thymine; Uracil; Xanthines | 1974 |
Requirements of Acholeplasma laidlawii A, strain LA 1, for nucleic acid precursors.
Topics: Acholeplasma laidlawii; Adenosine; Colorimetry; Cytidine; Cytosine; Deoxyribose; DNA, Bacterial; Guanine; Guanosine; Nephelometry and Turbidimetry; Nucleosides; Purines; Pyrimidines; Ribose; RNA, Bacterial; Thymidine; Thymine; Uracil; Uridine | 1974 |
Dipole moments of 2,4-diketopyrimidines. II. Uracil, thymine and their derivatives.
Topics: Chemical Phenomena; Chemistry, Physical; Chlorine; Dioxanes; Ethyl Ethers; Evaluation Studies as Topic; Fluorouracil; Isomerism; Light; Mathematics; Nitro Compounds; Optics and Photonics; Pyrimidines; Pyrimidinones; Spectrophotometry, Infrared; Thymine; Uracil | 1974 |
Virulent bacteriophage infection of Rhizobium leguminosarum.
Topics: Adenine; Bacteriophages; Carbon Isotopes; Cell-Free System; Cytosine; DNA, Bacterial; DNA, Viral; Guanine; Methyltransferases; Microscopy, Electron; Molecular Weight; Nucleotidases; Phosphotransferases; Rhizobium; RNA, Bacterial; Tetrahydrofolate Dehydrogenase; Thymidine; Thymine; Thymine Nucleotides; Uracil; Viral Proteins; Virus Replication | 1972 |
Tautomerism of uracil and thymine in aqueous solution: spectroscopic evidence.
Topics: Isomerism; Mathematics; Models, Chemical; Models, Theoretical; Spectrometry, Fluorescence; Stereoisomerism; Thymine; Ultraviolet Rays; Uracil | 1972 |
5-Hydroxymethyluracil in the DNA of a dinoflagellate.
Topics: Adenosine Monophosphate; Animals; Centrifugation, Density Gradient; Chromatography, Thin Layer; Cytosine; Cytosine Nucleotides; DNA; Eukaryota; Guanine Nucleotides; Nucleic Acid Denaturation; Phosphorus Isotopes; Spectrophotometry, Ultraviolet; Temperature; Thymine; Thymine Nucleotides; Uracil; Uracil Nucleotides | 1973 |
Chick-erythrocyte nucleus reactivation in heterokaryons: suppression by inhibitors of proteolytic enzymes.
Topics: Animals; Arginine; Cell Nucleus; Chickens; Chlorine; Depression, Chemical; DNA; Erythrocytes; Female; Fluorine; HeLa Cells; Humans; Hybrid Cells; Kinetics; Lysine; Phenylalanine; Protease Inhibitors; RNA; Sulfones; Thymidine; Thymine; Tosyl Compounds; Tritium; Uracil; Uridine | 1974 |
Solution studies of the nucleic acid bases and related model compounds. Solubility in aqueous alcohol and glycol solutions.
Topics: 1-Propanol; Adenine; Adenosine; Butanols; Cytosine; Deoxyadenosines; Ethanol; Glycols; Guanosine; Mathematics; Methanol; Nucleic Acid Denaturation; Nucleosides; Solubility; Spectrophotometry, Ultraviolet; Thermodynamics; Thymine; Uracil; Water | 1972 |
Transient and stable products in the pulse radiolysis of some dihydropyrimidine solutions.
Topics: Butanols; Electrons; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Pyrimidines; Radiation Dosage; Radiation Effects; Spectrophotometry; Spectrum Analysis; Thymine; Uracil; Water | 1974 |
Effects of phenethyl alcohol on phospholipid metabolism in Escherichia coli.
Topics: Acetates; Alcohols; Bacterial Proteins; Benzene Derivatives; Carbon Isotopes; Chloramphenicol; Chromatography, Thin Layer; Culture Media; DNA, Bacterial; Escherichia coli; Isoleucine; Lipids; Nalidixic Acid; Phenylalanine; Phosphatidylethanolamines; Phospholipids; RNA, Bacterial; Thymine; Tritium; Uracil; Valine | 1972 |
Response of Escherichia coli B-r to high concentrations of sucrose in a nutrient medium.
Topics: Bacterial Proteins; Carbon Isotopes; Cell Division; Cell Survival; Culture Media; Cytoplasm; DNA, Bacterial; Escherichia coli; Microscopy, Phase-Contrast; Osmosis; Proline; RNA, Bacterial; Spectrophotometry; Sucrose; Thymine; Time Factors; Uracil | 1972 |
Nucleic acid and protein synthesis during thymineless death in lysogenic and nonlysogenic thymine auxotrophs.
Topics: Bacterial Proteins; Carbon Isotopes; Coliphages; Culture Media; DNA, Bacterial; Escherichia coli; Leucine; Lysogeny; Mitomycins; Recombination, Genetic; RNA, Bacterial; Thymine; Uracil | 1972 |
Death and lysis of Escherichia coli 15TAU cells after pulse-interrupted thymine starvation.
Topics: Aerobiosis; Arginine; Bacteriolysis; Cell Survival; Colorimetry; Culture Media; Escherichia coli; Thymine; Time Factors; Uracil | 1972 |
"Compartmentalization" of Escherichia coli ribosomes and ribonucleic acid.
Topics: Bacteriolysis; Bile Acids and Salts; Carbon Isotopes; Cell Fractionation; Cell Membrane; Centrifugation; Centrifugation, Density Gradient; Deoxyribonucleases; DNA, Bacterial; Escherichia coli; Microscopy, Electron; Ribosomes; RNA Nucleotidyltransferases; RNA, Bacterial; RNA, Ribosomal; RNA, Transfer; Spheroplasts; Sucrose; Surface-Active Agents; Thymine; Tritium; Uracil | 1972 |
Specific inhibition of cell division by colicin E 2 without degradation of deoxyribonucleic acid in a new colicin sensitivity mutant of Escherichia coli.
Topics: Bacteriological Techniques; Carbon Isotopes; Cell Division; Colicins; Coliphages; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Hot Temperature; Lysogeny; Microscopy, Phase-Contrast; Mutation; Nucleic Acid Denaturation; Radiation Effects; RNA, Ribosomal; Thymine; Trypsin; Ultraviolet Rays; Uracil | 1972 |
Physiological factors in the regulation of alkaline phosphatase synthesis in Escherichia coli.
Topics: Adenine; Alkaline Phosphatase; Bacterial Proteins; Carbon Isotopes; Culture Media; Enzyme Induction; Escherichia coli; Genetics, Microbial; Guanine; Leucine; Mutation; Nucleotides; Phosphates; Phosphorus Isotopes; Thymine; Uracil | 1972 |
Effect of growth rate on the relative rates of synthesis of messenger, ribosomal and transfer RNA in Escherichia coli.
Topics: Carbon Isotopes; DNA, Bacterial; Escherichia coli; Guanine; Nucleic Acid Denaturation; Nucleic Acid Hybridization; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; Thymine; Time Factors; Uracil | 1972 |
Regulation of bacteriophage T5 development by ColI factors.
Topics: Adenine; Adsorption; Autoradiography; Carbon Isotopes; Colicins; Coliphages; DNA Nucleotidyltransferases; DNA, Viral; Electrophoresis, Disc; Escherichia coli; Extrachromosomal Inheritance; Leucine; Phosphorus Isotopes; RNA, Messenger; RNA, Viral; Thymidine; Thymine; Tritium; Uracil; Viral Proteins; Virus Replication | 1972 |
Histone-induced changes of protein synthesis in Escherichia coli.
Topics: Animals; Arginine; Bacterial Proteins; Carbon Isotopes; Cattle; Culture Media; Enzyme Induction; Escherichia coli; Galactosidases; Genetic Code; Genetics, Microbial; Histones; Leucine; Lysine; RNA, Bacterial; RNA, Messenger; Thymine; Thymus Gland; Time Factors; Uracil | 1972 |
Obfuscation of the activity of antifungal antimicrobics by culture media.
Topics: Amphotericin B; Antifungal Agents; Candida albicans; Culture Media; Cytosine; Pyrimidines; Thymine; Uracil | 1972 |
Regulation of macromolecular synthesis by putrescine in a conditional Escherichia coli putrescine auxotroph.
Topics: Bacterial Proteins; Carbon Isotopes; Cell Division; Centrifugation, Density Gradient; Chloramphenicol; Chromatography, DEAE-Cellulose; Culture Media; Cytoplasm; DNA, Bacterial; Escherichia coli; Genetics, Microbial; Leucine; Mutation; Nalidixic Acid; Putrescine; Ribosomes; RNA, Bacterial; Stimulation, Chemical; Thymine; Tritium; Uracil | 1972 |
Intracellular events in canavanine-treated, T4-infected Escherichia coli.
Topics: Amino Acids; Bacterial Proteins; Canavanine; Carbon Isotopes; Coliphages; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Molecular Weight; RNA, Bacterial; Stereoisomerism; Thymine; Time Factors; Tritium; Uracil; Viral Proteins; Virus Replication | 1972 |
Effect of paramagnetic ions upon formation of spore photoproduct in DNA irradiated with UV at -196 degrees C.
Topics: Chromatography; DNA, Bacterial; Escherichia coli; Magnesium; Manganese; Radiation Effects; Spores, Bacterial; Thymine; Tritium; Ultraviolet Rays; Uracil | 1972 |
Thymine and uracil catabolism in Escherichia coli.
Topics: Amino Acids; Carbon Dioxide; Carbon Isotopes; Culture Media; Escherichia coli; Nitrogen; Thymine; Uracil | 1972 |
A temperature-sensitive glycyl-transfer ribonucleic acid synthetase mutant of Escherichia coli.
Topics: Amino Acyl-tRNA Synthetases; Bacterial Proteins; Carbon Isotopes; Cell-Free System; Chromosome Mapping; DNA, Bacterial; Escherichia coli; Leucine; Lysogeny; Mutagens; Mutation; Nitrosoguanidines; RNA, Bacterial; Spectrophotometry; Temperature; Thymine; Transduction, Genetic; Tritium; Uracil; Uridine | 1973 |
Effect of cis-platinum(II)diamminodichloride on wild type and deoxyribonucleic acid repair deficient mutants of Escherichia coli.
Topics: Bacterial Proteins; Cell Survival; Cisplatin; DNA Repair; DNA, Bacterial; Escherichia coli; Isoleucine; Mitomycins; Mutation; Nucleic Acid Denaturation; Radiation Effects; RNA, Bacterial; Spectrophotometry; Temperature; Thymine; Tritium; Ultraviolet Rays; Uracil | 1973 |
Stringent control of intracellular proteolysis in Escherichia coli.
Topics: Amino Acids; Autoanalysis; Bacterial Proteins; Carbon Dioxide; Carbon Radioisotopes; DNA, Bacterial; Escherichia coli; Genes, Regulator; Leucine; Mutation; Nitrosoguanidines; Nucleic Acids; Phenylalanine; RNA, Bacterial; Stereoisomerism; Thymine; Tritium; Uracil | 1973 |
Studies on the biosynthesis of alpha-putrescinylthymine in bacteriophage phi W-14-infected Pseudomonas acidovorans.
Topics: Bacteriophages; Carbon Radioisotopes; Cell-Free System; Chromatography, Paper; DNA Replication; DNA, Viral; Escherichia coli; Formaldehyde; Pseudomonas; Putrescine; Pyrimidines; Serine; Spectrophotometry; Tetrahydrofolates; Thymidine; Thymidylate Synthase; Thymine; Transferases; Tritium; Uracil | 1973 |
Observation of resonances from some minor bases in the natural-abundance carbon-13 nuclear magnetic resonance spectrum of unfractionated yeast transfer ribonucleic acid. Evidence for fast internal motion of the dihydrouracil rings.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Fourier Analysis; Inosine; Magnesium; Magnetic Resonance Spectroscopy; Nucleotides; Pseudouridine; Ribose; RNA, Transfer; Saccharomyces cerevisiae; Thymine; Uracil; Uridine | 1974 |
Expression of tetracycline resistance mediated by an R-factor in Escherichia coli 15T-1.
Topics: Bacterial Proteins; Carbon Radioisotopes; Culture Media; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Extrachromosomal Inheritance; Glucose; Lactose; Leucine; Mutation; Nalidixic Acid; RNA, Bacterial; Streptomycin; Tetracycline; Thymine; Tritium; Uracil | 1974 |
Mutants of Escherichia coli with cold-sensitive deoxyribonucleic acid synthesis.
Topics: Alleles; Bacterial Proteins; Bacteriological Techniques; Carbon Radioisotopes; Cell Count; Chromosome Mapping; Cold Temperature; Conjugation, Genetic; DNA, Bacterial; Escherichia coli; Genetic Complementation Test; Leucine; Mutagens; Mutation; Nitrosoguanidines; Thymine; Toluene; Transduction, Genetic; Tritium; Uracil | 1974 |
[DNA synthesis and cell division in Escherichia coli 15 TAU following substrate limitation].
Topics: Arginine; Bacterial Proteins; Bacteriological Techniques; Cell Count; Cell Division; Culture Media; DNA Replication; DNA, Bacterial; Escherichia coli; Glucose; Mutation; Thymidine; Thymine; Time Factors; Tritium; Uracil | 1974 |
Heat-induced depyrimidination of deoxyribonucleic acid in neutral solution.
Topics: Bromouracil; Carbon Radioisotopes; Chromatography, Paper; Cytosine; DNA, Bacterial; Escherichia coli; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mutation; Nucleotides; Osmolar Concentration; Pyrimidines; Solubility; Thymine; Uracil | 1973 |
Detection of pyrimidine dimers in hydrolysates of yeast DNA by high voltage paper electrophoresis.
Topics: Ascomycota; Carbon Radioisotopes; DNA; DNA, Bacterial; Electrophoresis, Paper; Escherichia coli; Genetics, Microbial; Hydrolysis; Molecular Biology; Pyrimidines; Thymine; Tritium; Ultraviolet Rays; Uracil | 1974 |
Thymineless mutagenesis in Escherichia coli.
Topics: Arginine; Cell Count; Cell Survival; DNA Replication; DNA, Bacterial; Escherichia coli; Mutagens; Mutation; Nitrosoguanidines; RNA, Bacterial; Thymine; Tritium; Uracil | 1974 |
Growth and cell division of Escherichia coli 15 TAU after transfer to deficient media with different sources of carbon and energy.
Topics: Amino Acids; Arginine; Cell Count; Cell Division; Culture Media; DNA, Bacterial; Escherichia coli; Glucose; Glycerol; Mutation; Thymine; Uracil | 1974 |
Inhibition of ribonucleic acid synthesis by nalidixic acid in Escherichia coli.
Topics: Amino Acids; Bacterial Proteins; Carbon Radioisotopes; Chloramphenicol; Depression, Chemical; Escherichia coli; Glucose; Nalidixic Acid; RNA, Bacterial; RNA, Ribosomal; RNA, Transfer; Thymine; Uracil; Uracil Nucleotides | 1974 |
A highly sensitive method for the estimation of pyrimidine dimers in DNA by high-pressure liquid cation-exchange chromatography.
Topics: Carbon Radioisotopes; Chromatography, Ion Exchange; DNA, Bacterial; Escherichia coli; Evaluation Studies as Topic; Methods; Pressure; Radiation Effects; Spectrophotometry, Ultraviolet; Thymine; Tritium; Ultraviolet Rays; Uracil | 1974 |
Inhibition of peptide chain initiation in Escherichia coli by thermorubin.
Topics: Amino Acids; Anthraquinones; Anti-Bacterial Agents; Bacterial Proteins; Carbon Radioisotopes; Cell-Free System; Chlorella; DNA, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Mutation; Peptide Chain Initiation, Translational; Peptide Initiation Factors; Phenylalanine; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Thymine; Transcription, Genetic; Uracil | 1974 |
Thymine dimer excision in UV-irradiated and 5-fluorouracil-postincubated Escherichia coli.
Topics: Carbon Radioisotopes; Cell Count; Cell Survival; DNA Repair; DNA, Bacterial; Escherichia coli; Fluorouracil; Histidine; Mutation; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1974 |
An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues.
Topics: Binding Sites; Chromatography, Paper; Cytosine; Deoxycytidine Monophosphate; Deoxyuridine; DNA; DNA, Single-Stranded; Escherichia coli; Glucosidases; Magnesium; RNA; Thymine; Uracil; Uracil Nucleotides; Uridine Monophosphate | 1974 |
Nature of deoxyribonucleic acid synthesis and its relationship to protein synthesis during outgrowth of Bacillus cereus T.
Topics: Bacillus cereus; Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chloramphenicol; Colorimetry; Dactinomycin; DNA Repair; DNA Replication; DNA, Bacterial; Genetics, Microbial; Mutation; Peptide Hydrolases; Phenylalanine; Protein Denaturation; RNA, Bacterial; Spores; Spores, Bacterial; Thymidine; Thymine; Tritium; Uracil | 1972 |
Transport alterations in a phosphatidylethanolamine-deficient mutant of Bacillus subtilis.
Topics: Acetates; Adenosine; Amino Acids; Aspartic Acid; Bacillus subtilis; Biological Transport, Active; Carbon Isotopes; Cell Membrane; Culture Media; Genetics, Microbial; Glucose; Lysine; Mutation; Phosphatidylethanolamines; Pyruvates; Stereoisomerism; Thymine; Time Factors; Uracil; Uridine | 1972 |
The killing of sensitive cells by colicin D.
Topics: Amino Acids; Azides; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Colicins; Culture Media; Dinitrophenols; DNA, Bacterial; Edetic Acid; Escherichia coli; Genetics, Microbial; Kinetics; Mutation; RNA, Bacterial; Thymine; Tritium; Uracil | 1972 |
New deoxyribonucleic acid polymerase induced by Bacillus subtilis bacteriophage PBS2.
Topics: Bacillus subtilis; Bacteriophages; Cell-Free System; Chloramphenicol; Chromatography, Paper; Colorimetry; Dactinomycin; Deoxyribonucleosides; DNA Nucleotidyltransferases; DNA, Viral; Enzyme Induction; Magnesium; Thymine; Time Factors; Uracil; Virus Replication | 1972 |
Antibacterial properties of silver chelates of uracil and uracil derivatives in vitro.
Topics: Animals; Anti-Bacterial Agents; Bacillus subtilis; Bromouracil; Cattle; Centrifugation, Density Gradient; Chelating Agents; DNA, Bacterial; Dogs; Female; Male; Mice; Pseudomonas aeruginosa; Salmonella; Silver; Staphylococcus; Streptococcus; Thymine; Uracil; Uridine | 1972 |
[Aspects of thymine metabolism in Athiorhodaceae].
Topics: Carbon Isotopes; DNA Replication; DNA, Bacterial; Photosynthesis; Rhodobacter sphaeroides; Rhodopseudomonas; Rhodospirillum; Rhodospirillum rubrum; Thymine; Uracil; Uridine | 1972 |
5-Bromouracil-tolerant mutants of Bacillus subtilis.
Topics: Bacillus subtilis; Bromouracil; Caffeine; Carbon Isotopes; Cell Survival; Chromosome Mapping; Culture Media; DNA Replication; DNA, Bacterial; Drug Resistance, Microbial; Mutation; Radiation Effects; Spores, Bacterial; Thymine; Transformation, Genetic; Ultraviolet Rays; Uracil | 1972 |
On the nature of the radiation damage in the thymine containing strand of hybrid BU-DNA after long wave-length U.V.
Topics: Bacillus subtilis; Bacteriophages; Bromouracil; DNA; DNA, Bacterial; DNA, Viral; Dose-Response Relationship, Radiation; Genetics, Microbial; Thymine; Transformation, Genetic; Ultraviolet Rays; Uracil | 1972 |
Development of bacteriophage alpha. II. Dependence on the host ribonucleic acid polymerase.
Topics: Bacillus megaterium; Bacteriophages; Carbon Isotopes; Cell-Free System; DNA-Directed RNA Polymerases; DNA, Bacterial; Drug Resistance, Microbial; Lysogeny; Mutation; Rifampin; RNA, Bacterial; Thymidine; Thymine; Uracil; Uracil Nucleotides; Virus Replication | 1972 |
Autolysis of cells of Lactobacillus acidophilus induced by chloroform (effect of growth phase-murein).
Topics: Amino Acids; Bacteriolysis; Carbon Isotopes; Chloroform; Chromatography, Paper; Formaldehyde; Hydrogen-Ion Concentration; Iodine; Lactobacillus acidophilus; Oxidation-Reduction; Peptidoglycan; Temperature; Thymine; Tritium; Uracil | 1972 |
Ionizing radiation-initiated degradation of DNA in germinating spores.
Topics: Bacillus subtilis; Carbon Isotopes; Cobalt Isotopes; DNA, Bacterial; Proline; Radiation Effects; Spores, Bacterial; Thymine; Time Factors; Uracil | 1972 |
Deoxythymidylate phosphohydrolase induced by bacteriophage PBS2 during infection of Bacillus subtilis.
Topics: Bacillus subtilis; Bacteriophages; Deoxyribonucleotides; DNA, Viral; Enzyme Induction; Fluorides; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Mutation; Nucleotidases; Purine Nucleotides; Pyrimidine Nucleotides; Structure-Activity Relationship; Sulfhydryl Reagents; Thymidylate Synthase; Thymine; Thymine Nucleotides; Trypsin; Uracil; Uracil Nucleotides | 1973 |
A comparison of the utilization of thymine and thymidine as precursors for deoxyribonucleic acid synthesis in Bacillus subtilis, and their specific inhibition by 6-(p-hydroxyphenylazo)uracil and caffeine.
Topics: Azo Compounds; Bacillus subtilis; Caffeine; DNA Repair; DNA Replication; DNA, Bacterial; Phenols; Thymidine; Thymine; Tritium; Uracil | 1972 |
Sensitivity to myxin of Escherichia coli treated with ethylenediaminetetraacetic acid.
Topics: Anti-Bacterial Agents; Carbon Isotopes; Culture Media; DNA, Bacterial; Drug Resistance, Microbial; Edetic Acid; Escherichia coli; Micropore Filters; Muramidase; Oxides; Phenazines; RNA, Bacterial; Spectrophotometry; Spheroplasts; Thymine; Uracil | 1973 |
[Tritium splitting from solid, gamma irradiated uracil-5-T and uracil-6-T].
Topics: Adenine; Chemical Phenomena; Chemistry, Physical; Dose-Response Relationship, Radiation; Radiation; Radiation Effects; Thymine; Tritium; Uracil | 1972 |
Stimulation of growth on a deficient medium of a Klebsiella aerogenes species by sulphonamide, para-amino benzoic acid, nitrofurantoin, and some other substances.
Topics: Agar; Aminobenzoates; Aminosalicylic Acids; Culture Media; Klebsiella; Microbial Sensitivity Tests; Nitrofurantoin; Procaine; Sulfonamides; Thymine; Uracil | 1972 |
[On neighbourly relations in chemical mutagenesis].
Topics: Adenine; Cytosine; Guanine; Hydroxylamines; Mutagens; Nucleic Acids; Thymine; Uracil | 1972 |
Addition of hydroxyl radicals to pyrimidine bases and electron transfer reactions of intermediates to quinones.
Topics: Cytosine; Electrons; Energy Transfer; Free Radicals; Hydrogen-Ion Concentration; Quinones; Solutions; Spectrum Analysis; Thymine; Uracil | 1973 |
The effect of thiols on the dehalogenation of 5-iodo and 5-bromouracil.
Topics: Bromouracil; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Cysteine; Hydrogen-Ion Concentration; Kinetics; Mercaptoethanol; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Thymine; Uracil | 1973 |
Degradation of nucleic acids in the rumen.
Topics: Animals; Cattle; Chromatography, Ion Exchange; Chromatography, Thin Layer; DNA; Hypoxanthines; In Vitro Techniques; Nucleosides; Oligonucleotides; Purines; Pyrimidines; RNA; Rumen; Sheep; Thymine; Ultrafiltration; Uracil; Xanthines | 1973 |
Solid state ultraviolet irradiation of 1,1'-trimethylenebisthymine and photosensitized irradiation of 1,1'-polymethylenebisthymines.
Topics: Alkanes; Photochemistry; Polymers; Propane; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1973 |
Degradation of nucleic acid derivatives by rumen bacteria in vitro.
Topics: Adenosine; Animals; Bacteria; Cattle; Cell-Free System; Guanine; Guanosine; Hypoxanthines; In Vitro Techniques; Male; Nucleic Acids; Nucleosides; Nucleotides; Purines; Pyrimidines; Rumen; Thymine; Time Factors; Tissue Extracts; Uracil; Xanthines | 1973 |
The influx of purines and pyrimidines across the brush border of Hymenolepis diminuta.
Topics: Absorption; Adenine; Animals; Binding Sites; Bromouracil; Carbon Isotopes; Cestoda; Culture Media; Guanine; Hymenolepiasis; Hypoxanthines; Purines; Pyrimidines; Thymine; Uracil | 1973 |
Electron beam excitation and damage of biological molecules; its implications for specimen damage in electron microscopy.
Topics: Acridines; Adenine; Cytosine; DNA; Dose-Response Relationship, Radiation; Electrons; Guanine; Microscopy, Electron, Scanning; Polynucleotides; Radiation Effects; Ribosomes; Thymine; Uracil | 1973 |
Incorporation of adenine and uracil into the nucleic acids of Streptococcus bovis.
Topics: Adenine; Animals; Bacteria; Carbon Isotopes; Cattle; Chromatography; Culture Media; DNA, Bacterial; RNA, Bacterial; Rumen; Spectrophotometry; Streptococcus; Thymine; Uracil | 1973 |
Removal of pyrimidine dimers in cells of Schizosaccharomyces pombe mutated in different repair pathways.
Topics: Ascomycota; Chromatography, Ion Exchange; Chromatography, Paper; Cytosine; Darkness; DNA; DNA Repair; Mutation; Photochemistry; Pyrimidines; Radiation Effects; Thymine; Time Factors; Tritium; Ultraviolet Rays; Uracil | 1973 |
Separation of nucleic acid bases, nucleosides and nucleotides on Dowex 50 type resin-coated chromatoplates.
Topics: Absorption; Adenine Nucleotides; Adenosine; Amino Acid Sequence; Chromatography, Ion Exchange; Cytidine; DNA; Guanine Nucleotides; Hydrogen-Ion Concentration; Hydrolysis; Hypoxanthines; Ion Exchange Resins; Protein Hydrolysates; Ribonucleosides; Ribonucleotides; Spectrophotometry, Ultraviolet; Thymine; Uracil; Uridine; Xanthines | 1973 |
Chlorination studies. IV. The reaction of aqueous hypochlorous acid with pyrimidine and purine bases.
Topics: Adenine; Bromouracil; Caffeine; Chemical Phenomena; Chemistry; Guanine; Mass Spectrometry; Purines; Pyrimidines; Sodium Hypochlorite; Spectrophotometry, Ultraviolet; Theophylline; Thymine; Uracil; Xanthines | 1973 |
[Photochemistry of frozen aqueous solutions of mixtures of tryptophan with nucleic acid components].
Topics: Dose-Response Relationship, Radiation; Freezing; Photochemistry; Radiation Effects; Solutions; Spectrum Analysis; Thymine; Tryptophan; Ultraviolet Rays; Uracil; Uridine; Water | 1973 |
Structure and synthesis of dihydroxypentyluracil from bacteriophage SP-15 deoxyribonucleic acid.
Topics: Bacillus; DNA, Viral; Glycols; Magnetic Resonance Spectroscopy; Malates; Optical Rotation; Spectrophotometry, Ultraviolet; Thymine; Uracil | 1973 |
[The effect of a series of antibiotics on nucleic acid and protein synthesis in Salmonella pullorum].
Topics: Alanine; Bacterial Proteins; Carbon Radioisotopes; Chloramphenicol; DNA, Bacterial; Erythromycin; Lysine; RNA, Bacterial; Salmonella; Tetracycline; Thymine; Time Factors; Uracil | 1973 |
[The effect of oxytetracycline and chloramphenicol on protein and nucleic acid biosynthesis by Pasteurella multocida].
Topics: Bacterial Proteins; Carbon Radioisotopes; Chloramphenicol; DNA, Bacterial; Lysine; Oxytetracycline; Pasteurella; RNA, Bacterial; Thymine; Uracil | 1973 |
Redox potentials of free radicals. II. Pyrimidine bases.
Topics: Cytosine; Electron Transport; Free Radicals; Hydrogen-Ion Concentration; Hydroxylation; Kinetics; Mathematics; Potentiometry; Pyrimidines; Spectrophotometry; Thymine; Uracil | 1974 |
[The cleavage of tritium from solid, gamma-irradiated cytosine-5-T (author's transl)].
Topics: Adenine; Cytosine; Dose-Response Relationship, Radiation; Free Radicals; Radiation Effects; Thymine; Tritium; Uracil | 1974 |
Oxidation of nucleic acid bases by potassium peroxodisulfate in alkaline aqueous solution.
Topics: Adenine; Alkalies; Cytosine; Guanine; Kinetics; Oxidation-Reduction; Peroxides; Potassium; Purines; Purinones; Sulfates; Thymine; Uracil | 1974 |
Inhibition by 6-aminothymine of the degradation of nucleosides (5-iododeoxyuridine, thymidine) and pyrimidine bases (5-iodouracil, uracil and 5-fluorouracil) in vivo.
Topics: Amines; Animals; Antimetabolites; Bone Marrow; Chromatography; DNA; Fluorouracil; Idoxuridine; Intestinal Mucosa; Iodine Radioisotopes; Male; Mice; Nucleosides; Pentosyltransferases; Rabbits; Spleen; Thymidine; Thymine; Thymus Gland; Uracil | 1974 |
Photochemical and gamma-ray-induced reactions of nucleic acid constituents. Suppression of the reactivity of pyrimidines in the presence of purines.
Topics: Photochemistry; Purines; Pyrimidines; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1974 |
Ultraviolet-induced reactions of thymine and uracil in the presence of cysteine.
Topics: Carbon Radioisotopes; Chromatography, Thin Layer; Cysteine; Hydrogen-Ion Concentration; Isomerism; Kinetics; Photochemistry; Photolysis; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1974 |
Studies on bacteriophage and bacteriophage DNA containing 5-ethyluracil or 5-bromouracil in place of thymine.
Topics: Bromine; Chromatography, Thin Layer; Coliphages; DNA, Viral; Escherichia coli; Salts; Temperature; Thymine; Uracil | 1967 |
Base composition of rapidly-labelled RNA in E. coli undergoing thymineless death.
Topics: Adenine; Chromatography, Ion Exchange; Culture Media; Cytosine; Escherichia coli; Guanine; Molecular Biology; Mutation; RNA, Bacterial; Thymine; Uracil | 1967 |
Radiation-induced reorientation of chromosome replication sequence: generality in Escherichia coli; independence of prophage or 5-bromouracil toxicity.
Topics: Buffers; Carbon Isotopes; Chromosome Aberrations; Chromosomes; Coliphages; DNA; Escherichia coli; Glucose; Karyotyping; Kinetics; Nitrogen; Radiation Effects; Thymine; Tritium; Ultracentrifugation; Uracil | 1967 |
Thymidine and thymine incorporation into deoxyribonucleic acid: inhibition and repression by uridine of thymidine phosphorylase of Escherichia coli.
Topics: DNA, Bacterial; Enzyme Induction; Escherichia coli; Glucosyltransferases; Ligases; Nucleosides; Pentosephosphates; Pentoses; Thymidine; Thymidine Kinase; Thymine; Tritium; Uracil; Uridine | 1967 |
Induction of excessive deoxyribonucleic acid synthesis in Escherichia coli by nalidixic acid.
Topics: Arginine; Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chloramphenicol; Culture Media; DNA Replication; DNA, Bacterial; Escherichia coli; Ethanol; Nalidixic Acid; RNA, Bacterial; Thymine; Tritium; Uracil | 1967 |
Polyamines and the accumulation of ribonucleic acid in some polyauxotrophic strains of Escherichia coli.
Topics: Amides; Amines; Arginine; Carbon Isotopes; Centrifugation, Density Gradient; Chloramphenicol; Escherichia coli; Glucose; Leucine; Methionine; Mutation; Ribosomes; RNA, Bacterial; Streptomycin; Thymine; Uracil | 1967 |
Mode of action of myxin on Escherichia coli.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Glucose; Leucine; Orotic Acid; RNA, Bacterial; Thymine; Uracil | 1967 |
DNA degradation by decay from incorporated tritium compounds in escherichia coli.
Topics: Carbon Isotopes; DNA, Bacterial; Escherichia coli; Histidine; Radiation Effects; Thymine; Tritium; Uracil | 1968 |
Formation of filaments and synthesis of macromolecules at temperatures below the minimum for growth of Escherichia coli.
Topics: Bacterial Proteins; Carbon Isotopes; Cell Division; DNA, Bacterial; Escherichia coli; Leucine; Microscopy, Electron; Microscopy, Phase-Contrast; Pimelic Acids; Proline; RNA, Bacterial; Temperature; Thymine; Tritium; Uracil | 1968 |
A comparison of [13C]glucose-15NH4Cl with 5-bromouracil as density label in two experiments on sequential DNA replication in Escherichia coli 15T-.
Topics: Ammonium Chloride; Carbon Isotopes; DNA Replication; DNA, Bacterial; Escherichia coli; Glucose; Nitrogen; Radioisotopes; Thymine; Tritium; Uracil | 1968 |
Search for a mechanism for the increased sensitivity of 5-bromouracil-substituted DNA to ultraviolet radiation.
Topics: Bromine; Carbon Isotopes; Chromatography, Paper; Coliphages; Cysteamine; DNA, Bacterial; Escherichia coli; Iodoacetates; Radiation Effects; Thymidine; Thymine; Tritium; Uracil; Uridine | 1968 |
Replication of the escherichia coli K12 chromosome.
Topics: Amino Acids; Carbon Isotopes; Centrifugation, Density Gradient; Chromosome Mapping; Chromosomes, Bacterial; Culture Media; DNA Replication; DNA, Bacterial; Escherichia coli; Histidine; Lysine; Methionine; Models, Biological; Thymine; Transduction, Genetic; Tritium; Uracil | 1967 |
The effect of nucleosides on the phosphorolysis of thymidine by normal and phage-infected cells of E. coli.
Topics: Cell-Free System; Coliphages; Deoxyuridine; Escherichia coli; Nucleosides; Thymidine; Thymine; Triazines; Tritium; Uracil; Uridine | 1968 |
Selection of temperature-sensitive activating enzyme mutants in Escherichia coli.
Topics: Amino Acids; Bacterial Proteins; Carbon Isotopes; Escherichia coli; Ligases; Molecular Biology; Mutation; Proline; RNA, Bacterial; Temperature; Thymine; Tritium; Uracil | 1968 |
Growth and nucleic acid synthesis of Salmonella typhimurium inhibited by alpha-methylmethionine.
Topics: Bacterial Proteins; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Leucine; Methionine; RNA, Bacterial; Salmonella typhimurium; Thymine; Uracil | 1968 |
[Growth dynamics in E. coli T- culture in the presence of base analogs].
Topics: Azaguanine; Culture Media; Escherichia coli; Purines; Thymine; Uracil | 1966 |
Effect of some pre-treatments on UV-sensitivity and on the course of macromolecular synthesis in Escherichia coli 15 T-, U-, his-.
Topics: Bacterial Proteins; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Glucose; Histidine; Mutation; Radiation Effects; RNA, Bacterial; Thymine; Ultraviolet Rays; Uracil | 1968 |
Involvement of protein and ribonucleic acid in the association of deoxyribonucleic acid with other cell components of Escherichia coli.
Topics: Arginine; Bacterial Proteins; Bacteriolysis; Carbon Isotopes; Cell Membrane; Cell-Free System; Centrifugation, Density Gradient; Detergents; DNA, Bacterial; Electrophoresis, Disc; Escherichia coli; RNA, Bacterial; Thymidine; Thymine; Tritium; Tryptophan; Ultrasonics; Uracil | 1968 |
Efficiency of utilization of thymine and 5-bromouracil for normal and repair DNA synthesis in bacteria.
Topics: Bacteriolysis; Bromine; Centrifugation, Density Gradient; DNA Replication; DNA, Bacterial; Escherichia coli; Genetics, Microbial; Radiation Effects; Temperature; Thymine; Ultraviolet Rays; Uracil | 1968 |
Radiosensitivity of Escherichia coli 15T and the metabolic effect of cysteine.
Topics: Carbon Isotopes; Cysteine; DNA, Bacterial; Escherichia coli; Mutation; Phosphates; Phosphorus Isotopes; Radiation Effects; RNA, Bacterial; Thymine; Uracil | 1968 |
Postirradiation permeability of Escerichia coli cells.
Topics: Carbon Isotopes; Cell Membrane Permeability; Coliphages; DNA, Bacterial; Enzyme Induction; Escherichia coli; Oxygen; Radiation Effects; Thymine; Uracil | 1968 |
Effect of p-fluorophenylalanine on chromosome replication in Escherichia coli.
Topics: Amino Acids; Carbon Isotopes; Centrifugation, Density Gradient; Chromosomes, Bacterial; DNA Replication; DNA, Bacterial; Escherichia coli; Ligases; Phenylalanine; RNA, Transfer; Thymine; Tritium; Uracil | 1968 |
[Morphological and biochemical studies of the effect of barbituric acid, ureidosuccinic acid, orotic acid, uracil and thymine on the diabetogenic effect of alloxan].
Topics: Adrenal Glands; Alloxan; Amino Alcohols; Animals; Barbiturates; Blood Glucose; Diabetes Mellitus, Experimental; Female; Histological Techniques; Injections, Intraperitoneal; Kidney; Liver; Orotic Acid; Pancreas; Rats; Succinates; Thymine; Thyroid Gland; Uracil; Uric Acid | 1968 |
Effect of amino acids and purine bases on thiamine synthesis by Escherichia coli.
Topics: Adenine; Amino Acids; Aspartic Acid; Culture Media; Cystine; Cytosine; Escherichia coli; Glutamates; Glycine; Guanine; Histidine; Hypoxanthines; Inositol; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Purines; Serine; Thiamine; Thiazoles; Threonine; Thymine; Tyrosine; Uracil; Valine | 1968 |
Relationships between bactericidal effect and inhibition of ribonucleic acid nucleotidyltransferase by rifampicin in Escherichia coli K-12.
Topics: Bacterial Proteins; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Phenylalanine; Rifampin; RNA Nucleotidyltransferases; RNA, Bacterial; Thymine; Uracil | 1969 |
Chromosome replication in Salmonella typhimurium.
Topics: Amino Acids; Autoradiography; Carbon Isotopes; Centrifugation, Density Gradient; Chromosomes, Bacterial; Conjugation, Genetic; DNA Replication; DNA, Bacterial; Escherichia coli; Nitrogen; Radioisotopes; Salmonella typhimurium; Thymine; Tritium; Uracil | 1969 |
Absorption of microwaves by microorganisms.
Topics: Absorption; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Microwaves; Radiation Effects; RNA, Bacterial; Spectrum Analysis; Thymine; Uracil | 1969 |
[On pyrimidines. V. 5-Bromouracil-4-carbaldehyde].
Topics: Aldehydes; Bromine; DNA, Bacterial; Escherichia coli; Hydrazines; Mutation; Pyrimidines; Thymine; Uracil | 1969 |
Triazine nucleic acid interrelationship in Escherichia coli 15 arg-t-u.
Topics: Arginine; Carbon Isotopes; Culture Media; DNA, Bacterial; Escherichia coli; Genetics, Microbial; Mutation; RNA, Bacterial; Thymine; Triazines; Uracil | 1969 |
A study of the effects of hydrostatic pressure on macromolecular synthesis in Escherichia coli.
Topics: Bacterial Proteins; Carbon Isotopes; Cell Division; DNA, Bacterial; Escherichia coli; Kinetics; Leucine; Pressure; RNA, Bacterial; Temperature; Thymine; Uracil | 1969 |
Initiation of DNA replication cycles in Escherichia coli following DNA synthesis inhibition.
Topics: Amino Acids; Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chromosomes, Bacterial; Culture Media; DNA Replication; DNA, Bacterial; Escherichia coli; Membranes; Mutation; Temperature; Thymine; Tritium; Uracil | 1969 |
A new thymine base analogue, 5-ethyluracil: 5-ethyluridine-5'-pyrophosphate and poly-5-ethyluridylic acid.
Topics: Azotobacter; Chemical Phenomena; Chemistry; Chemistry, Physical; Chromatography, Paper; Escherichia coli; Hydrogen-Ion Concentration; Micrococcus; Nucleosides; Nucleotides; Pancreas; Polynucleotides; Pyrimidines; Ribonucleases; RNA Nucleotidyltransferases; Spectrophotometry; Temperature; Thymine; Ultraviolet Rays; Uracil; Uracil Nucleotides | 1969 |
Effect of U.V.-irradiated DNA containing 5-bromouracil on reactivation U.V. damage in phage lambda.
Topics: Bromine; Coliphages; DNA, Bacterial; DNA, Viral; Escherichia coli; Models, Chemical; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1969 |
Release of nuclear material from x-irradiated bacteria.
Topics: Arginine; Culture Media; Escherichia coli; Radiation Effects; Thymine; Uracil | 1970 |
Control of bacterophage development in Escherichia coli RCrel: events following infection of K12 relaxed strains with T2 and T3.
Topics: Amino Acids; Coliphages; Escherichia coli; Leucine; Ribosomes; RNA, Transfer; Thymine; Uracil | 1970 |
Properties of the deoxyribonucleic acid contained in the defective particle coliphage 15.
Topics: Arginine; Carbon Isotopes; Centrifugation; Centrifugation, Density Gradient; Cesium; Chlorides; Coliphages; Cytosine; Densitometry; Deoxyribonucleases; DNA, Viral; Escherichia coli; Filtration; Genetics, Microbial; Guanine; Hot Temperature; Hybridization, Genetic; Mitomycins; Molecular Weight; Nucleic Acid Denaturation; RNA, Messenger; Sucrose; Thymine; Ultraviolet Rays; Uracil | 1970 |
Thermal induction of bacteriophage Plb.
Topics: Bacterial Proteins; Coliphages; Culture Media; DNA, Bacterial; Escherichia coli; Hot Temperature; Lysogeny; Methionine; RNA, Bacterial; RNA, Messenger; Thymine; Uracil | 1970 |
New data on the toxic and radioprotective effect of cysteine on Escherichia coli 15 T- cells.
Topics: Bacterial Proteins; Carbon Isotopes; Centrifugation; Culture Media; Cysteine; DNA, Bacterial; Escherichia coli; Glucose; Hydrochloric Acid; Minerals; Proline; Radiation Effects; Radiation-Protective Agents; RNA, Bacterial; Thymine; Time Factors; Uracil | 1970 |
Amino acid control over deoxyribonucleic acid synthesis in Escherichia coli infected with T-even bacteriophage.
Topics: Amino Acids; Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Cesium; Chloramphenicol; Chlorides; Coliphages; Culture Media; DNA, Bacterial; DNA, Viral; Escherichia coli; Genetics, Microbial; Ligases; Mutation; Phenotype; Proline; Thymidine; Thymine; Transduction, Genetic; Tritium; Uracil; Uridine | 1970 |
The dampening of DNA replication cycles after x-irradiation or ultraviolet irradiation.
Topics: Carbon Isotopes; Centrifugation, Density Gradient; Cesium; DNA Replication; DNA, Bacterial; Escherichia coli; Nitrogen; Radiation Effects; Radioisotopes; Thymine; Time Factors; Ultraviolet Rays; Uracil | 1970 |
Near-U.V. photolysis of pyrimidine heteroadducts in E. coli DNA.
Topics: DNA, Bacterial; Escherichia coli; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1970 |
Action of photoreactivating light on pyrimidine heteroadduct in bacteria.
Topics: DNA, Bacterial; Escherichia coli; Radiation Effects; Staphylococcus; Thymine; Ultraviolet Rays; Uracil | 1970 |
Synthetic capabilities of plasmolyzed cells and spheroplasts of Escherichia coli.
Topics: Bacterial Proteins; Carbon Isotopes; Cell Membrane; Centrifugation, Density Gradient; DNA, Bacterial; Escherichia coli; Galactosidases; Histidine; Microscopy, Electron; Phospholipids; Ribosomes; RNA, Bacterial; Sucrose; Thymine; Tritium; Uracil | 1970 |
Greater vulnerability of the infecting viral strand of replicative-form deoxyribonucleic acid of bacteriophage phi X174.
Topics: Bromine; Centrifugation, Density Gradient; Cesium; Chlorides; Coliphages; Culture Media; DNA Replication; DNA, Viral; Escherichia coli; Genetics, Microbial; Light; Phosphorus Isotopes; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1970 |
The relationship between thymine-less death and growth rate in Escherichia coli 15 TAU.
Topics: Amino Acids; Arginine; Bacteriological Techniques; Bacteriolysis; Cell Division; Culture Media; Densitometry; Escherichia coli; Glucose; Glycerol; Thymine; Uracil | 1971 |
Division of Escherichia coli 15 TAU cells synchronized by arginine and uracil starvation.
Topics: Arginine; Bacteriological Techniques; Cell Division; Chromosomes, Bacterial; Culture Media; DNA, Bacterial; Escherichia coli; Genetics, Microbial; Microscopy, Phase-Contrast; Nalidixic Acid; Thymine; Uracil | 1971 |
Effect of 5-bromouracil on the growth of a thymine auxotroph of Escherichia coli K-12.
Topics: Bacteriological Techniques; Bromouracil; Cell Division; Escherichia coli; Penicillin Resistance; Penicillins; Spectrophotometry; Thymine; Uracil | 1971 |
Survival and macromolecular synthesis during incubation of Escherichia coli in limiting thymine.
Topics: Arginine; Bacterial Proteins; Bacteriological Techniques; Carbon Isotopes; Culture Media; DNA Replication; DNA, Bacterial; Escherichia coli; RNA, Bacterial; Thymine; Tritium; Ultraviolet Rays; Uracil | 1971 |
Electron energy loss spectra of the nucleic acid bases.
Topics: Adenine; Cytosine; Electrons; Energy Transfer; Guanine; Microscopy, Electron, Scanning; Spectrum Analysis; Thymine; Uracil | 1971 |
DNA synthesis in Escherichia coli in the presence of cyanide.
Topics: Arginine; Carbon Isotopes; Chromatography, DEAE-Cellulose; Chromosomes, Bacterial; Cyanides; DNA Nucleotidyltransferases; DNA, Bacterial; Escherichia coli; Nucleotides; Pyridines; Thymidine; Thymine; Tritium; Uracil | 1971 |
Production of pyrimidine dimers in DNA in the dark.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Paper; Darkness; DNA, Bacterial; Escherichia coli; Hydrolysis; Isomerism; Peroxides; Polymers; Pyrimidines; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1971 |
Influence of ribosides on ultraviolet resistance of Escherichia coli: role of deoxyribonucleic acid synthesis in the ultraviolet resistance enhancement after amino acid prestarvation.
Topics: Amino Acids; Bacterial Proteins; Carbon Isotopes; Culture Media; Densitometry; DNA Replication; DNA, Bacterial; Escherichia coli; Glucose; Leucine; Nucleosides; Radiation Effects; RNA, Bacterial; Thymine; Time Factors; Tryptophan; Ultraviolet Rays; Uracil | 1971 |
Phases of thymineless death in Escherichia coli 15 TAU.
Topics: Agar; Arginine; Bacteriological Techniques; Bacteriolysis; Caffeine; Cell Division; Cell Survival; Colorimetry; Culture Media; DNA Replication; DNA, Bacterial; Escherichia coli; Genetics, Microbial; Thymine; Time Factors; Tritium; Uracil | 1971 |
Breakage of bacterial DNA by nitrofuran derivatives.
Topics: Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; DNA Repair; DNA, Bacterial; Escherichia coli; Genetics, Microbial; Leucine; Mutation; Nitrofurans; Nitrofurantoin; Nitrofurazone; Nucleic Acid Denaturation; RNA, Bacterial; Thymine; Tritium; Uracil | 1971 |
A screening test for urinary purines and pyrimidines and related compounds using auxotrophic mutants of Escherichia coli K12.
Topics: Adenine; Alanine; Aspartic Acid; Biological Assay; Carbamates; Child; Chromatography, Paper; Cytosine; Escherichia coli; Glycosides; Humans; Imidazoles; Inosine; Mutation; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Purinones; Pyrimidines; Ribose; Thymine; Uracil; Uric Acid | 1970 |
Methionineless death in Escherichia coli.
Topics: Amino Acyl-tRNA Synthetases; Arginine; Bacterial Proteins; Bacteriological Techniques; Carbon Isotopes; Cell Survival; Culture Media; Decarboxylation; DNA, Bacterial; Escherichia coli; Filtration; Isoleucine; Leucine; Methionine; Proline; Spermidine; Spermine; Thymine; Tryptophan; Uracil | 1971 |
The incorporation of glucose to Escherichia coli cells in the presence of noncarbohydrate carbon.
Topics: Adenine; Adenosine Triphosphate; Aerobiosis; Amino Acids; Calorimetry; Carbon; Carbon Dioxide; Carbon Isotopes; Culture Media; Escherichia coli; Glucose; Guanine; Hot Temperature; Manometry; Oxidation-Reduction; Oxygen Consumption; Purines; Pyrimidines; Thymine; Uracil; Vitamins | 1971 |
Regulation of synthesis of alkaline phosphatase by deoxyribonucleic acid synthesis in a constitutive mutant of Bacillus subtilis.
Topics: Alkaline Phosphatase; Bacillus subtilis; Carbon Isotopes; Dactinomycin; DNA, Bacterial; Enzyme Repression; In Vitro Techniques; Mitomycins; Mutation; Thymine; Uracil | 1966 |
Use of exogenous adenine to label the nucleic acids of wild-type Neisseria meningitidis.
Topics: Adenine; Carbon Isotopes; Cytosine; DNA, Bacterial; Guanine; Neisseria meningitidis; Nucleosides; Ribose; RNA, Bacterial; Thymine; Tritium; Uracil | 1967 |
5-bromouracil utilization by Bacillus subtilis.
Topics: Bacillus subtilis; Bromine; Bromodeoxyuridine; Centrifugation, Density Gradient; DNA, Bacterial; Thymidine; Thymine; Uracil | 1967 |
Protective effect of 6-azathymine and 6-azauracil against the lethal effect of ultraviolet irradiation. II. Isolation of thymine photoproducts from the nucleic acids of Streptococcus faecalis.
Topics: Carbon Isotopes; Chromatography, Paper; DNA, Bacterial; Enterococcus faecalis; Radiation Effects; Thymidine; Thymine; Triazines; Tritium; Ultraviolet Rays; Uracil | 1967 |
Characterization of a temperature-sensitive mutant of Bacillus subtilis defective in deoxyribonucleic acid replication.
Topics: Bacillus subtilis; Carbon Isotopes; Chloramphenicol; DNA Replication; DNA, Bacterial; Kinetics; Mutation; Photomicrography; RNA, Bacterial; Spores; Temperature; Thymine; Tryptophan; Uracil | 1967 |
Sequential replication of the Bacillus subtilis chromosome. IV. Genetic mapping by density transfer experiment.
Topics: Amino Acid Sequence; Bacillus subtilis; Bromine; Centrifugation, Density Gradient; Chromosome Mapping; Chromosomes, Bacterial; Deuterium; DNA; Hybridization, Genetic; Phosphorus Isotopes; Spores; Statistics as Topic; Thymine; Transformation, Genetic; Tritium; Uracil | 1967 |
DNA synthesis by Lactobacillus acidophilus during glutamic acid starvation.
Topics: Bacterial Proteins; Carbon Isotopes; DNA, Bacterial; Glutamates; Histidine; Lactobacillus acidophilus; RNA, Bacterial; Thymidine; Thymine; Tritium; Uracil | 1967 |
Lysis of Escherichia coli with a neutral detergent.
Topics: Amino Acids; Bacterial Proteins; Bacteriolysis; Carbon Isotopes; Centrifugation, Density Gradient; Detergents; Edetic Acid; Escherichia coli; Magnesium; Microscopy, Phase-Contrast; Molecular Weight; Muramidase; Ribosomes; RNA; RNA, Transfer; Solubility; Thymine; Time Factors; Uracil | 1967 |
Control of the synthesis of macromolecules during amino acid and thymine starvation in Bacillus subtilis.
Topics: Amino Acids; Bacillus subtilis; Bacterial Proteins; Cell Division; Cell Wall; Centrifugation, Density Gradient; Chromosome Mapping; Chromosomes, Bacterial; Culture Media; DNA, Bacterial; Phosphorus Isotopes; Thymine; Transformation, Genetic; Tritium; Uracil | 1968 |
[Incorporation of thymine and cytosine analogs into bacterial deoxyribonucleic acid].
Topics: Antimetabolites; Bacteria; Bromine; Carbon Isotopes; Chlorine; DNA, Bacterial; Enterococcus faecalis; Escherichia coli; Thymine; Uracil | 1967 |
[The effect of pyrimidine derivatives on the antitumor action and toxicity of thio-TEPA].
Topics: Animals; Carcinoma, Ehrlich Tumor; Male; Mice; Neoplasms, Experimental; Pyrimidines; Thiotepa; Thymine; Uracil | 1968 |
Transducing particles of PBS 1.
Topics: Bacillus subtilis; Bacteriophages; Centrifugation, Density Gradient; DNA, Bacterial; DNA, Viral; Microscopy, Electron; Phosphorus Isotopes; Thymidine; Thymine; Transduction, Genetic; Tritium; Uracil | 1968 |
6-Oxa isosteres of uracil and thymine.
Topics: Biological Assay; Chemical Phenomena; Chemistry; Densitometry; Depression, Chemical; Electrons; Enterococcus faecalis; Escherichia coli; Ethers; Lactobacillus; Leuconostoc; Pyrimidines; Spectrophotometry; Thymine; Uracil | 1969 |
Biological activity of 5-hydroxymethyluracil and its deoxynucleoside in noninfected and phage-infected Bacillus subtilis.
Topics: Bacillus subtilis; Bacteriophages; Carbon Isotopes; Centrifugation, Density Gradient; Deoxyuridine; DNA, Bacterial; DNA, Viral; Mutation; Thymine; Uracil; Virus Replication | 1969 |
Effect of adenine on picornaviruses and isolation of an adenine-resistant mutant of echovirus type 7.
Topics: Adenine; Adenine Nucleotides; Animals; Culture Techniques; Cytosine; Drug Resistance, Microbial; Enterovirus; Enterovirus B, Human; Haplorhini; Kidney; Mutation; Nucleosides; Purines; Pyrimidines; RNA, Viral; Sulfates; Thymine; Uracil; Virus Cultivation; Virus Replication | 1969 |
Rifamycins LXI: in vivo inhibition of RNA synthesis of rifamycins.
Topics: Bacillus subtilis; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Phenylalanine; Rifampin; RNA, Bacterial; Thymine; Uracil | 1968 |
Potassium requirement for synthesis of macromolecules in Bacillus subtilis infected with bacteriophage 2C.
Topics: Bacillus subtilis; Bacteriophages; Carbon Isotopes; DNA, Bacterial; DNA, Viral; Leucine; Mutation; Potassium; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Viral; Thymine; Tritium; Uracil | 1969 |
The metabolism of bacterial nucleic acid and of free components of nucleic acid by the rumen ciliate Entodinium caudatum.
Topics: Adenine; Animals; Carbon Isotopes; Ciliophora; Escherichia coli; Guanine; Nucleic Acids; Phosphorus Isotopes; Purines; Pyrimidines; Thymine; Uracil | 1968 |
Synthesis of DNA in phage-infected Bacillus subtilis.
Topics: Bacillus subtilis; Bacteriophages; Carbon Isotopes; Centrifugation, Density Gradient; Chloramphenicol; DNA, Bacterial; DNA, Viral; Enzyme Induction; Hydrolases; Mutation; Temperature; Thymine; Transferases; Uracil | 1969 |
Inhibition of bacterial DNA and protein synthesis in Bacillus subtilis by phage SP82. Effect of changes of temperature on the inhibition.
Topics: Adenine; Amino Acids; Bacillus subtilis; Bacterial Proteins; Bacteriolysis; Bacteriophages; Carbon Isotopes; Chloramphenicol; DNA, Bacterial; Electrophoresis, Disc; Lyases; Mutation; Nucleotides; Temperature; Thymidine; Thymine; Transferases; Uracil | 1969 |
Chemical investigations of the molecular origin of biological radiation damage.
Topics: Chemical Phenomena; Chemistry; Cytosine; DNA; Nucleotides; Purines; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1969 |
Studies on the purine-sensitive mutants of Bacillus subtilis. I. Properties of an adenosine-sensitive mutant.
Topics: Bacillus subtilis; Cytosine; Guanine; Hypoxanthines; Ligases; Nucleosides; Purines; Pyrimidines; Spectrophotometry; Thymidine; Thymine; Uracil; Uridine | 1969 |
[Effect of desoxystreptamine-containing antibiotics on incorporation of labelled amino acids and precursors of nucleic acids in different fractions of Proteus vulgaris and Pseudomonas aeruginosa].
Topics: Alanine; Amino Acids; Anti-Bacterial Agents; Aspartic Acid; Bacterial Proteins; Cell Wall; Depression, Chemical; DNA, Bacterial; Erythromycin Ethylsuccinate; Gentamicins; Glycine; Kanamycin; Leucine; Lysine; Methionine; Neomycin; Proteus; Pseudomonas aeruginosa; RNA, Bacterial; Thymine; Time Factors; Tyrosine; Uracil | 1969 |
DNA synthesis in Lactobacillus acidophilus in the absence of RNA and protein synthesis: a study with rifampicin.
Topics: Bacterial Proteins; DNA, Bacterial; Lactobacillus acidophilus; Leucine; Nucleotides; Rifampin; RNA, Bacterial; Thymine; Tritium; Uracil | 1969 |
Effect of actinomycin D on the transfer of ribonucleic acid from nucleus to cytoplasm in Lactobacillus acidophilus.
Topics: Autoradiography; Biological Transport; Carbon Isotopes; Cell Nucleus; Culture Media; Cytoplasm; Dactinomycin; DNA, Bacterial; Lactobacillus acidophilus; Microscopy, Electron; RNA, Bacterial; Thymine; Tritium; Uracil; Uridine | 1970 |
[Utilization of pyrimidine derivatives by Hydrogenomonas facilis. II. Degradation of thymine and uracil by wild type and mutants].
Topics: Aminohydrolases; Bacterial Proteins; Cell-Free System; Culture Media; Cytosine; Fructose; Genetics, Microbial; Hydro-Lyases; Mutation; Nitrogen; Orotic Acid; Oxidoreductases; Penicillins; Pseudomonas; Thymine; Uracil | 1969 |
Mechanism of the sensitization of bacterial transforming DNA to ultraviolet light by the incorporation of 5-bromouracil.
Topics: Bacillus subtilis; DNA, Bacterial; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1970 |
[Mechanism of action of trypanocide diamidines. Importance of base composition in the berenil-polynucleotides association].
Topics: Adenine; Antiprotozoal Agents; Binding Sites; Chemical Phenomena; Chemistry; DNA; DNA, Bacterial; Spectrum Analysis; Thymine; Ultracentrifugation; Uracil | 1970 |
[Fluorescence of purine and pyrimidine bases at room temperature].
Topics: Adenine; Cytosine; Fluorescence; Guanine; Hydrogen-Ion Concentration; Purines; Pyrimidines; Spectrum Analysis; Temperature; Thymine; Uracil | 1971 |
Control of DNA synthesis in Bacillus subtilis by phage phi e.
Topics: Adenine; Bacillus subtilis; Bacteriophages; Carbon Isotopes; Centrifugation, Density Gradient; Cesium; Chloramphenicol; Chlorides; DNA Nucleotidyltransferases; DNA, Bacterial; DNA, Viral; Genetic Complementation Test; Genetics, Microbial; Mutation; Nucleotidases; Thymidine; Thymine; Uracil | 1971 |
[Experiences in the use of methyluracil and pentoxyl in surgery].
Topics: Humans; Regeneration; Thymine; Tissue Adhesions; Uracil; Wound Healing | 1972 |
Heavy atoms in model compounds and nucleic acid imaged by dark field transmission electron microscopy.
Topics: Base Sequence; Benzene Derivatives; Benzoates; Coliphages; Darkness; Densitometry; DNA, Viral; Elements; Iodine; Microscopy, Electron; Osmium; Palladium; Platinum; Polynucleotides; Thymine; Uracil; Uracil Nucleotides; Uranium | 1972 |
[Protonation of thymine, uracil and its 5-haloid-derivatives].
Topics: Bromouracil; Fluorouracil; Protons; Thymine; Uracil | 1972 |
Triplet state studies of the nucleoside and nucleotide derivatives of uracil and thymine.
Topics: Kinetics; Mathematics; Oxygen; Photolysis; Radiation Effects; Spectrophotometry; Thymidine; Thymine; Thymine Nucleotides; Ultraviolet Rays; Uracil; Uracil Nucleotides; Uridine | 1972 |
Determination of the distribution of 5-bromouracil and 5-iodouracil in the DNA of viable and total phage populations.
Topics: Bromouracil; Centrifugation, Density Gradient; Coliphages; DNA, Viral; Phosphates; Phosphorus Isotopes; Thymine; Tritium; Uracil | 1972 |
Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo.
Topics: Animals; Azo Compounds; Dactinomycin; Depression, Chemical; DNA; DNA, Neoplasm; Fluorouracil; Intestine, Small; Iodine Isotopes; Leukemia, Experimental; Liver; Male; Nucleosides; Oxidoreductases; Pyrimidines; Rats; RNA; RNA, Neoplasm; Spleen; Thymidine; Thymine; Tritium; Uracil | 1972 |
Effect of 5-diazouracil on the synthetic and catabolic utilization of thymine in rat liver.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Carbon Isotopes; Cycloheximide; Dactinomycin; Depression, Chemical; DNA; Liver; Oxidoreductases; Pyrimidines; Rats; Stimulation, Chemical; Thymine; Uracil | 1972 |
Ultraviolet photochemistry of DNA in mouse spermatozoa.
Topics: Animals; Carbon Isotopes; Cytosine; DNA; Kinetics; L Cells; Male; Methods; Mice; Mice, Inbred Strains; Photochemistry; Radiation Dosage; Radiation Effects; Spermatozoa; Thymidine; Thymine; Tritium; Ultraviolet Rays; Uracil | 1972 |
[Use of methyluracyl and pentoxyl in surgery].
Topics: Acute Disease; Appendicitis; Chronic Disease; Humans; Pancreatitis; Postoperative Care; Stomach Diseases; Thymine; Uracil; Wound Healing | 1972 |
Enrichment of 18 O in the nucleic acid bases.
Topics: Bromouracil; DNA; Isotope Labeling; Mass Spectrometry; Oxygen Isotopes; Radiation Effects; RNA; Structure-Activity Relationship; Thymine; Ultraviolet Rays; Uracil; Water | 1972 |
In vivo inhibition of pyrimidine catabolism by 5-cyanouracil.
Topics: Animals; Carbon Dioxide; Fluorouracil; Liver; Metabolism; Pyrimidines; Rats; Thymine; Time Factors; Uracil | 1971 |
The effect of 5-bromouracil on energy transfer in DNA and related model systems. Purine: pyrimidine crystal complexes.
Topics: Adenine; Adenosine; Bromouracil; Crystallography; DNA; Energy Transfer; Kinetics; Luminescent Measurements; Models, Chemical; Purines; Pyrimidines; Radiation Effects; Spectrum Analysis; Temperature; Thymine; Uracil; Uridine | 1971 |
The mechanism of aristeromycin. I. Growth inhibition of Xanthomonas oryzae by aristeromycin.
Topics: Adenine; Adenosine; Anti-Bacterial Agents; Cytidine; Cytosine; Deoxyuridine; Guanine; Guanosine; Hypoxanthines; Inosine; Nucleosides; Thymidine; Thymine; Uracil; Uridine; Xanthines; Xanthomonas | 1971 |
Analysis of base composition of RNA and DNA hydrolysates by gas-liquid chromatography.
Topics: Adenine; Animals; Base Sequence; Cattle; Charcoal; Chromatography, Gas; Chromatography, Ion Exchange; Cytosine; DNA; Guanine; Hydrogen-Ion Concentration; Hydrolysis; Ion Exchange Resins; Male; Methods; Methylation; Microchemistry; Purines; Pyrimidines; RNA; Salmonidae; Spermatozoa; Thymine; Thymus Gland; Tissue Extracts; Uracil; Yeasts | 1971 |
Gas-liquid chromatography of some pyrimidine derivatives.
Topics: Bromine; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Gas; Cytosine; Fluorouracil; Mathematics; Methods; Phenanthrenes; Pyrimidines; Silicon; Thymine; Triazines; Uracil | 1971 |
Purine binding to dinucleotides: evidence for base stacking and insertion.
Topics: Chemical Phenomena; Chemistry, Physical; Magnetic Resonance Spectroscopy; Nucleotides; Protons; Purines; Thymine; Uracil | 1966 |
Pyrimidine dimers in UV-irradiated poly dI:dC.
Topics: Chemical Phenomena; Chemistry; Cytosine; Cytosine Nucleotides; Polynucleotides; Pyrimidines; Radiation Effects; Spectrophotometry; Thymine; Ultraviolet Rays; Uracil | 1965 |
Thymine and uracil-thymine dimers and deoxyribonucleic acid synthesis in mammalian cells irradiated with ultraviolet light.
Topics: Animals; Chromosomes; Culture Media; DNA; L Cells; Mammals; Mutation; Radiation Effects; Thymine; Tritium; Ultraviolet Rays; Uracil | 1966 |
Gamma-irradiation of nucleic-acid constituents in de-aerated aqueous solutions. 3. Thymine and uracil.
Topics: Carbon Isotopes; Cobalt Isotopes; Glycols; Radiation Effects; Solutions; Spectrophotometry; Thymine; Uracil | 1966 |
Studies on the chemical basis of cellular radiosensitization by 5-bromouracil substitution in DNA. I. Pulse- and steady-state radiolysis of 5-bromouracil and thymine.
Topics: Bromine; Chemical Phenomena; Chemistry; Cobalt Isotopes; DNA; Free Radicals; Kinetics; Light; Models, Chemical; Radiation Effects; Radiation-Sensitizing Agents; Radiochemistry; Spectrophotometry; Thymine; Uracil | 1969 |
Lack of photoreactivation in human cells grown in vitro.
Topics: Amnion; Cell Line; Chromatography; Culture Techniques; Cytosine; DNA; HeLa Cells; Humans; Light; Pyrimidines; Radiation Effects; Thymidine; Thymine; Tritium; Ultraviolet Rays; Uracil | 1970 |
Interaction of various bacteriocins with Klebsiella edwardsii var. edwardsii.
Topics: Bacterial Proteins; Bacteriocins; Carbon Isotopes; Depression, Chemical; DNA, Bacterial; Drug Resistance, Microbial; Escherichia; Genetics, Microbial; Klebsiella; Leucine; Mutation; Oxidative Phosphorylation; RNA, Bacterial; Thymine; Uracil | 1971 |
Photosensitized splitting of pyrimidine dimers by indole derivatives.
Topics: 5-Hydroxytryptophan; Carbon Isotopes; Chromatography, Paper; Electron Transport; Fluorescence; Freezing; Orotic Acid; Photochemistry; Radiation Effects; Spectrophotometry; Thymine; Tryptophan; Ultraviolet Rays; Uracil | 1971 |
Mechanism of action of phenolic disinfectants. V. Effect of 2,4-dichlorophenol on the incorporation of labeled substrates by Escherichia coli.
Topics: Acetates; Adenine; Carbon Isotopes; Escherichia coli; Glucose; In Vitro Techniques; Leucine; Phenols; Succinates; Sulfates; Sulfur Isotopes; Thymine; Uracil | 1965 |
Benzo[a]pyrene uptake by bacteria and yeast.
Topics: Benzopyrenes; Carbon Isotopes; Chromatography; Coliphages; Enterobacter; Escherichia coli; Glucose; Hot Temperature; In Vitro Techniques; Penicillins; Saccharomyces; Salmonella typhimurium; Thymine; Uracil | 1965 |
X-ray-induced perturbations in the replication of the bacterial chromosome.
Topics: Carbon Isotopes; Chromosomes; DNA, Bacterial; Escherichia coli; In Vitro Techniques; Radiation Genetics; Thymidine; Thymine; Tritium; Uracil | 1965 |
The process of infection with bacteriophage phi-XD174. VI. Inactivation of infected complexes by ultraviolet irradiation.
Topics: Coliphages; Culture Media; DNA, Viral; Escherichia coli; In Vitro Techniques; Photometry; Thymine; Ultraviolet Rays; Uracil | 1965 |
Replacement of 5-methyluracil (thymine) by 5-ethyluracil in bacterial DNA.
Topics: Chromatography, Paper; DNA, Bacterial; Escherichia coli; In Vitro Techniques; Pyrimidines; Thymine; Uracil | 1965 |
Autoradiographic studies of bacterial chromosome replication in amino-acid deficient Escherichia coli 15T-.
Topics: Arginine; Autoradiography; Chromosomes; DNA, Bacterial; Escherichia coli; Histidine; In Vitro Techniques; Micromanipulation; Mutation; Thymine; Uracil | 1965 |
Studies on the specification of accessory biochemical characters, as exemplified by the fatty acid patterns of various strains of Escherichia coli.
Topics: Chromatography, Gas; Culture Media; DNA, Bacterial; Escherichia coli; Fatty Acids; In Vitro Techniques; Methionine; Molecular Biology; Mutation; Thymine; Uracil | 1965 |
The action of ionizing radiation on postirradiation synthesis and degradation of DNA in Escherichia coli 15 T L.
Topics: Carbon Isotopes; Cell Division; DNA, Bacterial; Escherichia coli; Hot Temperature; In Vitro Techniques; Radiation Effects; Thymine; Uracil | 1966 |
X-ray-induced degradation of deoxyribonucleic acid in a polyauxotrophic bacterium.
Topics: Bromine; Carbon Isotopes; Chromosomes; DNA, Bacterial; Escherichia coli; In Vitro Techniques; Radiation Effects; Thymine; Ultracentrifugation; Uracil | 1966 |
Nonconservative DNA replication in bacteria after thymine starvation.
Topics: DNA, Bacterial; Escherichia coli; In Vitro Techniques; Models, Theoretical; Mutation; Thymine; Ultraviolet Rays; Uracil | 1965 |
The biological importance of ultraviolet light induced DNA-protein crosslinks in Escherichia coli 15 TAU.
Topics: Arginine; Bacterial Proteins; Chemical Phenomena; Chemistry; DNA, Bacterial; Escherichia coli; In Vitro Techniques; Mutation; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1966 |
Studies on the acid-soluble nucleotide pool in thymine-requiring mutants of Escherichia coli during thymine starvation. II. Changes in the amounts of deoxycytidine triphosphate and deoxyadenosine triphosphate in Escherichia coli 15 T-A-U.
Topics: Adenine; Adenosine Triphosphate; Bacterial Proteins; Chemistry Techniques, Analytical; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cytosine Nucleotides; Escherichia coli; In Vitro Techniques; Molecular Biology; Mutation; Thymine; Uracil | 1966 |
The influence of thymine and 5-bromouracil on the sensitivity of Escherichia coli to alkylation, UV and x-irradiation.
Topics: Alkylation; Bromine; DNA, Bacterial; Escherichia coli; In Vitro Techniques; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1966 |
The capacity of the bacterial host for the reproduction of the RNA phage f2. II. Its UV sensitivity in 5-BU labelled host and the effect of the thymineless death.
Topics: Coliphages; Escherichia coli; In Vitro Techniques; Molecular Biology; Mutation; Radiation Effects; RNA Viruses; Thymine; Ultraviolet Rays; Uracil | 1966 |
The effect of hydrostatic pressure on the synthetic processes in bacteria.
Topics: Bacterial Proteins; DNA, Bacterial; Escherichia coli; Galactosidases; In Vitro Techniques; Molecular Biology; Pressure; Proline; RNA, Bacterial; Thymine; Uracil; Valine | 1966 |
Effect of 9-beta-D-arabinofuranosyladenine on polymer synthesis in a polyauxotrophic strain of Escherichia coli.
Topics: Adenine Nucleotides; Aminohydrolases; Arginine; Bacterial Proteins; Carbon Isotopes; Culture Media; DNA, Bacterial; Escherichia coli; Hypoxanthines; Mutation; Polymers; Radiometry; RNA, Bacterial; Thymine; Uracil | 1966 |
Polymer synthesis in killed bacteria: lethality of 2',3'-dideoxyadenosine.
Topics: Adenine; Adenine Nucleotides; Arginine; Bacterial Proteins; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Nucleosides; Polymers; Radiometry; RNA, Bacterial; Streptomycin; Thymine; Uracil | 1966 |
Sensitization of Escherichia coli to radiation by bromouracil: excessive post-irradiation breakdown of deoxyribonucleic acid without concomitant synthesis.
Topics: Bromine; Bromodeoxyuridine; DNA, Bacterial; Escherichia coli; Radiation Effects; Thymine; Uracil | 1966 |
Production of additional sites of deoxyribonucleic acid breakdown in bromouracil containing Escherichia coli exposed to ultra-violet light.
Topics: Bromine; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Mitomycins; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1966 |
Thymineless radiosensitization in Escherichia coli.
Topics: DNA, Bacterial; Escherichia coli; Radiation-Sensitizing Agents; RNA, Bacterial; Thymidine; Thymine; Tryptophan; Uracil | 1966 |
The lethality of streptomycin and the stimulation of RNA synthesis in the absence of protein synthesis.
Topics: Adenine; Arginine; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Guanine; Kanamycin; Neomycin; Phosphates; RNA, Bacterial; Streptomycin; Sulfur Isotopes; Thymine; Uracil | 1966 |
Utilization of 5-bromouracil by thymineless bacteria.
Topics: Bromine; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Mutation; Thymine; Tritium; Ultracentrifugation; Uracil | 1967 |
Regulation of deoxyribonucleic acid synthesis in Escherichia coli: dependence on growth rates.
Topics: Arginine; Autoradiography; DNA, Bacterial; Escherichia coli; Leucine; Methionine; Mutation; Thymine; Tryptophan; Uracil | 1966 |
Control of deoxynucleotide biosynthesis in Escherichia coli. I. Decrease of pyrimidine deoxynucleotide biosynthesis in vivo in the presence of deoxythymidylate.
Topics: Carbon Isotopes; Chromatography, Ion Exchange; DNA, Bacterial; Escherichia coli; Nucleotides; Thymine; Tritium; Uracil | 1967 |
Developmental consequences of introduction of bromouracil into the DNA of sea urchin embryos during early division stages.
Topics: Animals; Bromodeoxyuridine; Cell Division; DNA; Echinodermata; Microscopy, Phase-Contrast; Thymine; Uracil | 1967 |
Selectivity for thymine over 5-bromouracil by a thymine-requiring bacterium.
Topics: Centrifugation, Density Gradient; DNA, Bacterial; Escherichia coli; Mutation; Thymine; Uracil | 1966 |
On the regulation of cell division.
Topics: Aldehydes; Bacterial Proteins; Cell Division; DNA, Bacterial; Escherichia coli; Leucine; RNA, Bacterial; Thymine; Uracil | 1966 |
Fluorinated pyrimidines. 28. The synthesis of 5-trifluoromethyl-6-azauracil and 5-trifluoromethyl-6-aza-2'-deoxyuridine.
Topics: Adenocarcinoma; Animals; Chemistry, Organic; Culture Techniques; Escherichia coli; Female; HeLa Cells; Ketones; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nucleosides; Nucleotides; Organic Chemistry Phenomena; Thymine; Triazines; Uracil | 1966 |
Ribonucleic acid synthesis by Escherichia coli C 3000/L after infection by the ribonucleic acid coliphage ZIK/1, and properties of the coliphage-induced double-stranged ribonucleic acid.
Topics: Bacteriolysis; Carbon Isotopes; Chromatography; Coliphages; DNA, Bacterial; Escherichia coli; Nucleic Acids; Phosphates; Phosphorus Isotopes; RNA, Bacterial; RNA, Transfer; RNA, Viral; Thymine; Uracil | 1966 |
Inhibition of repressor formation in the lactose system of Escherichia coli by inhibitors of protein synthesis.
Topics: Antimetabolites; Chloramphenicol; DNA, Bacterial; Enzyme Repression; Escherichia coli; Fluorouracil; Galactosidases; Hot Temperature; Lactose; Mutation; Puromycin; RNA, Bacterial; Thymine; Uracil | 1966 |
Some effects of bromouracil on the kinetics of thymineless death in Escherichia coli.
Topics: DNA, Bacterial; Escherichia coli; Kinetics; Thymine; Uracil | 1966 |
Physical and chemical characterization of two- and three-stranded adenine-thymine and adenine-uracil homopolymer complexes.
Topics: Adenine; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry; DNA; Escherichia coli; Nucleotidyltransferases; Polymers; Spectrophotometry; Thymine; Uracil | 1966 |
Normal replication of DNA after repair replication in bacteria.
Topics: Bacteriological Techniques; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Radiation Effects; Thymine; Tritium; Ultraviolet Rays; Uracil | 1967 |
Concerning the dynamics of chromosome replication and degradation in a bacterial population exposed to X-rays.
Topics: Bromine; Carbon Isotopes; Centrifugation, Density Gradient; Chromosomes; DNA; Escherichia coli; Radiation Effects; Radiation Genetics; Thymidine; Thymine; Tritium; Ultracentrifugation; Uracil | 1967 |
Mutants affecting thymidine metabolism in Neurospora crassa.
Topics: Carbon Isotopes; Chromatography; Genetics, Microbial; Molecular Biology; Mutation; Neurospora; Pyrimidines; RNA; Thymidine; Thymine; Transferases; Uracil | 1969 |
Alkylation by alcohols in the prescence of dicyclohexylcarbodiimide. Alkylation of thymine, uracil, thymidine, and uridine by alcohols.
Topics: Alcohols; Alkylation; Imides; Nucleosides; Pyrimidines; Thymidine; Thymine; Uracil; Uridine | 1969 |
Thin-layer chromatography of nucleic acid bases, nucleosides, nucleotides and related compounds. IX. Quantitative analysis in situ reflectance spectroscopy.
Topics: Cartilage; Chromatography, Thin Layer; Hypoxanthines; Methods; Nucleosides; Purines; Pyrimidines; Spectrum Analysis; Thymine; Tissue Extracts; Uracil; Uridine | 1969 |
The molecular configuration of pyrimidines that causes allosteric activation of uracil transport in Hymenolepis diminuta.
Topics: Animals; Binding Sites; Biological Transport; Carbon Isotopes; Cestoda; Chemical Phenomena; Chemistry; Depression, Chemical; Kinetics; Male; Membrane Transport Proteins; Pyrimidines; Rats; Stimulation, Chemical; Thymine; Uracil; Uridine | 1969 |
Effect of chloride ions on the gamma-radiation induced destruction of nucleic acid bases in aqueous solution. UCLA 12-724.
Topics: Chemical Phenomena; Chemistry; Chlorides; Cytosine; Free Radicals; Pyrimidinones; Radiation Effects; Thymine; Uracil | 1969 |
[New possibilities in the treatment of epithelioma].
Topics: Animals; Fluorouracil; Humans; Precancerous Conditions; Rats; Skin Neoplasms; Thymine; Uracil | 1969 |
The effect of "muscle cornin" on nucleic acid synthesis of carcinoma cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; In Vitro Techniques; Male; Methods; Mice; Muscles; Nucleic Acids; Peptides; Rabbits; Thymidine; Thymine; Tissue Extracts; Tritium; Uracil; Uridine | 1969 |
Base-pairing configurations between purines and pyrimidines in the solid state. 3. Crystal and molecular structure of two 2:1 hydrogen-bonded complexes, 1-methylthymine: 9-ethyl-2,6-diaminopurine and 1-methyl-5-iodouracil: 9-ethyl-2,6-diaminopurine.
Topics: Chemical Phenomena; Chemistry, Physical; Crystallography; Models, Structural; Purines; Thymine; Uracil; X-Ray Diffraction | 1969 |
Incorporation of labeled nucleic acid and protein precursors by diapausing and nondiapausing blastocysts.
Topics: Alanine; Animals; Autoradiography; Caniformia; Carbon Isotopes; Dactinomycin; DNA; Embryo Implantation; Female; In Vitro Techniques; Lactation; Mink; Morphogenesis; Ovum; Pregnancy; Protein Biosynthesis; Puromycin; Rabbits; Rats; RNA; RNA, Messenger; Thymine; Uracil; Urease; Valine; Xenarthra | 1969 |
Replication of the small coliphage M13: evidence for long-living M13 specific messenger RNA.
Topics: Coliphages; Electrophoresis; Hybridization, Genetic; RNA, Messenger; RNA, Viral; Thymine; Time Factors; Trichloroacetic Acid; Tritium; Uracil; Uridine; Virus Replication | 1970 |
In vitro studies on longwave ultraviolet light-dependent reactions of the skin photosensitizer chlorpromazine with nucleic acids, purines and pyrimidines.
Topics: Adenine; Chemical Phenomena; Chemistry; Chlorpromazine; Cytosine; DNA; Fluorescence; Photosensitivity Disorders; Purines; Pyrimidines; Radiation Effects; RNA; Spectrum Analysis; Thymine; Tritium; Ultraviolet Rays; Uracil | 1970 |
A new method for treatment of carcinoma of the breast and colon with 5-fluorouracil.
Topics: Adult; Aged; Breast Neoplasms; Chemical Phenomena; Chemistry; Colonic Neoplasms; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Thymine; Uracil | 1970 |
Reactions between singlet oxygen and the constituents of nucleic acids. Importance of reactions in photodynamic processes.
Topics: Chemical Phenomena; Chemistry; Guanine Nucleotides; Hydrogen-Ion Concentration; Light; Nucleic Acids; Nucleosides; Oxidation-Reduction; Oxygen; Polynucleotides; Purines; Pyrimidines; Radiation Effects; Spectrophotometry; Thymine; Ultraviolet Rays; Uracil | 1970 |
Pulse radiolysis of nucleic acid constituents and related compounds. 3. Optical spectra and reactivity of organic free radicals formed by reaction of hydroxyl free radicals with pyrimidine bases.
Topics: Cytosine; Electrons; Free Radicals; Hydrogen-Ion Concentration; Nucleic Acids; Pyrimidines; Radiation Effects; Radiochemistry; Spectrophotometry; Thymine; Uracil | 1970 |
Base-pairing configurations between purines and pyrimidines in the solid state. V. Crystal and molecular structure of two 1:1 hydrogen-bonded complexes, 1-methyluracil: 9-ethyl-8-bromo-2,6-diaminopurine and 1-ethylthymine: 9-ethyl-8-bromo-2,6--diaminopuri
Topics: Chemical Phenomena; Chemistry; Crystallography; Purines; Pyrimidines; Temperature; Thymine; Uracil | 1970 |
Crystal structures of dimers of uracil and 6-methyluracil.
Topics: Light; Polymers; Radiochemistry; Thymine; Uracil; X-Ray Diffraction | 1970 |
Partial denaturation of thymine- and 5-bromouracil-containing lambda DNA in alkali.
Topics: Coliphages; DNA, Viral; Hydrogen-Ion Concentration; Microscopy, Electron; Molecular Biology; Nucleic Acid Denaturation; Thymine; Uracil | 1970 |
[Problems of the chemotaxonomy of protozoa].
Topics: Adenine; Animals; Cytosine; DNA; Eukaryota; Guanine; Methods; Molecular Weight; RNA; RNA, Messenger; RNA, Transfer; Thymine; Uracil | 1970 |
Uracil-thymine adduct from a mixture of uracil and thymine irradiated with ultraviolet light.
Topics: DNA; Infrared Rays; Magnetic Resonance Spectroscopy; Photochemistry; Pyrimidinones; Radiation Effects; Spectrum Analysis; Thymine; Ultraviolet Rays; Uracil | 1970 |
Infectious DNA from coliphage T1. II. Host-cell reactivation of UV-irradiated molecules.
Topics: Coliphages; Cysteamine; DNA, Bacterial; Genetics, Microbial; Kinetics; Radiation Genetics; Thymine; Uracil | 1970 |
[Effect of 4-methyl uracil on nucleotide content and uracil degradation in liver of albino rats].
Topics: Adenine Nucleotides; Animals; Chromatography; Guanine Nucleotides; Liver; Nucleosides; Nucleotides; Rats; Thymine; Uracil; Uridine | 1970 |
Studies of the affinity of nuclear material for uroporphyrin. 3. Histones, nucleic acids, and bases.
Topics: Acetone; Adenine; Animals; Cattle; Chemical Precipitation; Chromatography, Gel; Cytosine; Dialysis; DNA; Fluorometry; Glutamates; Guanine; Histones; Humans; Hydrogen-Ion Concentration; Lysine; Peptides; Porphyrins; RNA; Saccharomyces; Serum Albumin; Spectrophotometry; Thymine; Thymus Gland; Uracil | 1970 |
Properties of the triplet states of thymine and uracil in aqueous solution.
Topics: Absorption; Kinetics; Photolysis; Polymers; Spectrum Analysis; Thymine; Uracil | 1971 |
Models of specifically paired like (homologous) nucleic acid structures.
Topics: Adenine; Cytosine; Guanine; Methods; Models, Chemical; Molecular Biology; Nucleic Acids; Protein Binding; Thymine; Uracil | 1971 |
Cytoplsmic uridine phosphorylase of rat liver. Characterization and kinetics.
Topics: Animals; Benzoates; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Computers; Cytoplasm; Deoxyribonucleosides; Electrophoresis, Disc; Hexoses; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Molecular Weight; Pentosephosphates; Phosphates; Protein Binding; Rats; Ribose; Sulfhydryl Compounds; Thymidine; Thymine; Time Factors; Transferases; Uracil; Uridine | 1971 |
A simple paper chromatographic method for separation of methylated adenines and cytosine from the major bases found in nucleic acids.
Topics: Adenine; Base Sequence; Carbon Isotopes; Cellulose; Chromatography, Paper; Cytosine; DNA; Guanine; Hydrolysis; Methionine; Methods; Methylation; Nucleic Acids; Nucleotides; Phosphoric Acids; Purines; Pyrimidines; RNA; RNA, Ribosomal; Thymine; Tritium; Uracil | 1971 |
Thymine: a possible prebiotic synthesis.
Topics: Chromatography, Paper; Chromatography, Thin Layer; Formaldehyde; Humans; Hydrazines; Nucleotides; Thymine; Uracil | 1971 |
Indication of gene amplification in Rhynchosciara by RNA-DNA hybridization.
Topics: Adenine; Animals; Cytosine; Diptera; DNA; Female; Genes; Guanine; Hybridization, Genetic; Larva; Molecular Biology; Ovary; RNA; RNA, Ribosomal; Salivary Glands; Thymine; Tritium; Uracil | 1971 |
18-O studies of the 2-ketoglutarate-dependent sequential oxygenation of thymine to 5-carboxyuracil.
Topics: Ascorbic Acid; Carboxylic Acids; Catalase; Chemical Phenomena; Chemistry; Chromatography, Gas; Formates; Iron; Ketoglutaric Acids; Mass Spectrometry; Neurospora; Oxygen Isotopes; Oxygenases; Silicon; Succinates; Thymine; Uracil | 1971 |
[Peroxides produced from thymine by gamma irradiation in aerated solution].
Topics: Alcohols; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; DNA; Free Radicals; Hot Temperature; Hydantoins; Hydrogen Peroxide; Infrared Rays; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Oxides; Peroxides; Radiation Effects; Silver; Spectrophotometry; Stereoisomerism; Thymine; Ultraviolet Rays; Uracil | 1971 |
Incorporation of 14C-labeled carbohydrates, pyrimidines, lipid components and amino acids into Lee influenza virus and chorioallantoic tissue in culture.
Topics: Acetates; Amino Acids; Butyrates; Carbon Isotopes; Cholesterol; Culture Techniques; Glutamates; Hemagglutinins, Viral; Leucine; Lipid Metabolism; Monosaccharides; Orthomyxoviridae; Thymine; Uracil | 1967 |
Further studies on the mutation with glucose oxime: the reaction of the oxime with T4 phage and nucleic acids.
Topics: Chemical Phenomena; Chemistry; Coliphages; Cytosine; DNA, Viral; Glucose; Hydrogen-Ion Concentration; Mutagens; Mutation; Nucleic Acids; Oximes; Purines; RNA, Viral; Spectrophotometry; Thymine; Ultraviolet Rays; Uracil | 1967 |
Photosensitized dimerization of pyrimidines.
Topics: Acetone; Acetophenones; Benzophenones; Carbon Isotopes; Chemical Phenomena; Chemistry, Physical; Cytosine; Orotic Acid; Pyrimidines; Radiation Effects; Thermodynamics; Thymine; Ultraviolet Rays; Uracil | 1968 |
Nucleosides. XLV. 1-alpha-L-aldo-pentofuranosylpyrimidines.
Topics: Animals; Antineoplastic Agents; Arabinose; Burkitt Lymphoma; Culture Techniques; Cytosine; Humans; Kidney; Leukemia L1210; Liver; Methods; Mice; Nucleosides; Pyrimidines; Thymine; Uracil; Xylose | 1968 |
The chemical composition of the nucleic acids and the proteins of some mycoplasma strains.
Topics: Adenine; Amino Acids; Bacterial Proteins; Cytosine; DNA, Bacterial; Guanine; Mycoplasma; RNA, Bacterial; Thymine; Uracil | 1968 |
Regulatory effect of N6-benzyladenine and pseudothymine (6-methyluracyl) on the synthesis of nucleic acids.
Topics: Adenine; Carbon Isotopes; Orotic Acid; Plants; Purines; Pyrimidines; RNA; Thymine; Uracil | 1968 |
Specific hydrogen bonding of barbiturates to adenine derivatives.
Topics: Adenine; Barbiturates; Chemical Phenomena; Chemistry; Infrared Rays; Models, Theoretical; Protein Binding; Spectrum Analysis; Thymine; Uracil | 1968 |
[Effect of purines and pyrimidines on the growth of Corynebacterium sepedonicum (Spiek. & Kott.) Skapt. & Burkh].
Topics: Adenine; Corynebacterium; Cytosine; Guanine; Hypoxanthines; Purines; Pyrimidines; Thymine; Uracil; Xanthines | 1968 |
Urinary pyrimidines after x-irradiation.
Topics: Animals; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Colorimetry; Cytosine; Female; Nucleosides; Radiation Effects; Rats; Spectrophotometry; Thymidine; Thymine; Time Factors; Tritium; Uracil | 1968 |
A two-dimensional thin-layer chromatographic technique for the separation of admixtures of 5-bromouracil and DNA bases.
Topics: Adenine; Bromine; Chromatography, Thin Layer; Cytosine; DNA; Guanine; Methods; Thymine; Uracil | 1968 |
Thymine starvation by inhibition of uptake and synthesis of thymine-compounds in Tetrahymena.
Topics: Cell Division; DNA; Hot Temperature; Methotrexate; Nucleosides; Tetrahymena; Thymidine; Thymine; Tritium; Uracil; Uracil Nucleotides; Uridine | 1968 |
Fish liver pyrimidine deoxynucleoside phosphorylase and deoxyribosyltransferase.
Topics: Adenine; Animals; Chromatography; Cytosine; Deoxyuridine; Electrophoresis; Glucosyltransferases; Hydrogen-Ion Concentration; Hypoxanthines; Kinetics; Liver; Mercaptoethanol; Nucleosides; Phosphates; Salmonidae; Spectrophotometry; Temperature; Thymidine; Thymine; Uracil | 1968 |
Studies on an interesting Saccharomyces carlsbergensis mutant.
Topics: Cytosine; Lysine; Mutation; Pyrimidines; Saccharomyces; Thymine; Ultraviolet Rays; Uracil | 1968 |
Bromouracil-resistant mutant of Chlamydomonas.
Topics: DNA; Eukaryota; Mutation; Thymine; Uracil | 1968 |
Ribonucleic acid polymerase from Micrococcus lysodeikticus. I. Studies on single stranded homopolynucleotide templates containing adenine, thymine, and uracil.
Topics: Adenine; Adenosine Triphosphate; Carbon Isotopes; Chemical Phenomena; Chemistry; Kinetics; Micrococcus; Polynucleotides; RNA Nucleotidyltransferases; Templates, Genetic; Thymine; Tritium; Uracil; Uracil Nucleotides | 1968 |
DNA biosynthesis by isolated mitochondria: a replicative rather than a repair process.
Topics: Animals; Bromodeoxyuridine; Centrifugation, Density Gradient; DNA; DNA Replication; DNA, Bacterial; Micrococcus; Mitochondria, Liver; Nucleotides; Rats; Thymine; Tritium; Uracil | 1968 |
Element analysis in labeled DNA by x-ray fluorescence.
Topics: Animals; Bromine; Calcium; Chlorine; Chromium; DNA; DNA, Neoplasm; Elements; Fluorometry; Guanine; HeLa Cells; Iodine; Male; Methods; Phosphorus; Salmonidae; Spectrum Analysis; Spermatozoa; Sulfur; Thymine; Uracil; X-Ray Diffraction; Zinc | 1968 |
Purine and pyrimidine synthesis by the avian malaria parasite, Plasmodium lophurae.
Topics: Adenine; Animals; Bicarbonates; Carbon Isotopes; Cytosine; Ducks; Erythrocytes; Formates; Guanine; Ligases; Malaria, Avian; Plasmodium; Purines; Pyrimidines; Thymine; Transferases; Uracil | 1968 |
Iterative extended Hückel study of nucleic acid bases.
Topics: Adenine; Chemical Phenomena; Chemistry; Cytosine; Guanine; Mathematics; Thymine; Uracil | 1968 |
Antagonists of an antifungal substance, polyoxin.
Topics: Adenine; Amino Acids; Antifungal Agents; Ascomycota; Ascorbic Acid; Caseins; Fungi; Mitosporic Fungi; Nitrogen; Peptones; Pyrimidines; Spectrophotometry; Streptomyces; Thymine; Ultraviolet Rays; Uracil; Xanthines; Yeasts | 1968 |
A new technique of pH gradient electrophoresis as applied to the separation of nucleic acid bases.
Topics: Adenine; Cytosine; Electrophoresis; Guanine; Hydrogen-Ion Concentration; Methods; Thymine; Uracil | 1968 |
Ribonucleic acid polymerase from Micrococcus lysodeikticus. II. Studies on double stranded homopolynucleotide templates.
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Binding Sites; Carbon Isotopes; Kinetics; Micrococcus; Models, Structural; Pentoses; Polynucleotides; Ribose; RNA Nucleotidyltransferases; Templates, Genetic; Thymine; Tritium; Uracil; Uracil Nucleotides | 1969 |
An infrared study of the hydrogen-bonding specificity of hypoxanthine and other nucleic acid derivatives.
Topics: Adenine; Chemical Phenomena; Chemistry; Cytosine; Guanine; Hydrogen; Hypoxanthines; Infrared Rays; Spectrum Analysis; Thermodynamics; Thymine; Uracil | 1969 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. I. Biological aspects.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Carbon Tetrachloride Poisoning; Drug Synergism; Embryo, Mammalian; Female; Fluorouracil; Injections, Intraperitoneal; Kidney; Liver; Male; Maternal-Fetal Exchange; Pregnancy; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1969 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. II. Biochemical aspects.
Topics: Animals; Carbon Isotopes; Depression, Chemical; DNA; Drug Synergism; Embryo, Mammalian; Extraembryonic Membranes; Female; Fluorouracil; Formates; Injections, Intraperitoneal; Ligases; Liver; Male; Phosphorus; Phosphorus Isotopes; Pregnancy; Rats; Thymidine; Thymidine Kinase; Thymine; Uracil | 1969 |
Determination of acid pK values of some pyrimidine derivatives.
Topics: Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Pyrimidines; Thymine; Uracil; Urea | 1969 |
Mass spectra of some dimeric photoproducts of pyrimidines.
Topics: Chemical Phenomena; Chemistry; Light; Spectrum Analysis; Thymine; Uracil | 1969 |
Why does DNA contain thymine and RNA uracil?
Topics: Chemical Phenomena; Chemistry; DNA; Light; Mutation; Radiation Genetics; RNA; Thymine; Uracil | 1969 |
Incorporation of radioactive label from pyrimidines into liver lipids.
Topics: Animals; Cytosine; Lipid Metabolism; Lipids; Liver; Nucleic Acids; Proteins; Pyrimidines; Rats; Thymine; Tritium; Uracil | 1969 |
The reaction of nucleic acid components with m-chloroperoxybenzoic acid.
Topics: Adenine; Benzoates; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Paper; Chromatography, Thin Layer; Cyclic N-Oxides; Hydrogen-Ion Concentration; Kinetics; Nucleic Acids; Nucleosides; Nucleotides; Osmolar Concentration; Peroxides; Potentiometry; Pyrimidinones; Spectrophotometry; Temperature; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uridine | 1969 |
[Chromatography of radiolysis products of thymine].
Topics: Barbiturates; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Cobalt Isotopes; Hydantoins; Radiation Effects; Thymine; Uracil; Urea | 1969 |
Interaction of oxidized polyamines with DNA. 3. Association with nucleosides, mono- and polynucleotides.
Topics: Adenine; Adenine Nucleotides; Aldehydes; Amines; Animals; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Cytosine; DNA; Electrophoresis; Guanine; Guanine Nucleotides; Imines; Nucleic Acid Denaturation; Nucleosides; Nucleotides; Polynucleotides; Spectrophotometry; Spermine; Thymine; Thymus Gland; Tritium; Uracil | 1969 |
Base alterations of nucleic acids in stomach wall after prolonged atropine treatment.
Topics: Adenine; Animals; Atropine; Chromatography, Paper; Cytosine; DNA; Gastric Mucosa; Guanine; Purines; Pyrimidines; Rats; RNA; Spectrophotometry; Thymine; Uracil | 1969 |
[Effects of gamma rays on pyrimidine bases in the solid state. I. Effects on uracil and thymine].
Topics: Radiation Effects; Thymine; Uracil | 1965 |
Determination of base sequence in nucleic acids with the electron microscope. IV. Nucleoside complexes with certain metal ions.
Topics: Adenine; Chemical Phenomena; Chemistry, Physical; Copper; Cytosine; Guanine; Hydrogen-Ion Concentration; Lead; Microscopy, Electron; Nucleosides; Spectrophotometry; Thymine; Uracil | 1965 |
Quantum-mechanical study on the photodimerization of aromatic molecules.
Topics: Chemical Phenomena; Chemistry, Physical; Energy Transfer; Light; Models, Theoretical; Pyrimidines; Radiation Effects; Thymine; Uracil | 1965 |
Transducing fragments in generalized transduction by phage P1. I. Molecular origin of the fragments.
Topics: Bacteriolysis; Centrifugation; Coliphages; Culture Media; DNA, Viral; In Vitro Techniques; Mutation; Phosphates; Thymidine; Thymine; Uracil | 1965 |
[Effects of 5-fluorouracil and 6-methylpurine on development of the egg of the sea urchin Paracentrotus lividus].
Topics: Animals; Antimetabolites; DNA; Echinodermata; Embryo, Nonmammalian; Female; Fluorouracil; In Vitro Techniques; Ovum; RNA; Thymine; Uracil | 1965 |
Spectrophotometric and chemical studies of 5-mercaptouracil, 5-mercaptodeoxyuridine, and their S-substituted derivatives.
Topics: Antineoplastic Agents; Antiviral Agents; Deoxyuridine; Spectrophotometry; Thymidine; Thymine; Ultraviolet Rays; Uracil | 1966 |
Anomalous electrophoretic behavior of purine and pyrimidine derivatives in triethylammonium buffers.
Topics: Acetates; Adenine; Bicarbonates; Buffers; Carbonates; Cytosine; Formates; Guanine; Purines; Pyrimidines; Quaternary Ammonium Compounds; Thymine; Uracil; Uracil Nucleotides; Uridine; Xanthines | 1966 |
Effects of ultraviolet radiation on RNA C-C glycosyls and other derivatives of uracil.
Topics: Chemical Phenomena; Chemistry, Physical; Fluorouracil; Nucleosides; Radiation Effects; RNA, Transfer; Spectrophotometry; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uridine | 1966 |
The decrepitude of the rat brain with special reference to changes in nucleic acid.
Topics: Adenine; Aging; Animals; Brain Chemistry; Brain Stem; Cerebellum; Chromatography; Cytosine; Diencephalon; DNA; Guanine; Rats; RNA; Thymine; Uracil | 1966 |
Rapid column chromatography of purine and pyrimidine bases on 'Ectaola' cellulose at room temperature and elevated pressure.
Topics: Adenine; Cellulose; Chromatography, Ion Exchange; Cytosine; DNA; Formates; Guanine; Hot Temperature; Pressure; RNA; Thymine; Uracil | 1966 |
[On the effect of hydrazine and methylsubstituted hydrazines on nucleosides, nucleotides and ribonucleic acids].
Topics: Chemical Phenomena; Chemistry; Cytosine; Cytosine Nucleotides; Hydrazines; Hydrogen-Ion Concentration; Nucleosides; Nucleotides; RNA; Thymidine; Thymine; Uracil; Uracil Nucleotides; Uridine | 1966 |
Studies on chemotherapeutic agents. I. A synthesis of pyrimidine nucleosides of D-glucuronic acid and its derivatives.
Topics: Chemistry, Organic; Cytosine; Glucuronates; Nucleosides; Organic Chemistry Phenomena; Pyrimidines; Thymine; Uracil | 1966 |
Effect of adenine on the photodynamic inactivation of yeast alcohol dehydrogenase in the presence of riboflavin.
Topics: Adenine; Adenine Nucleotides; Alcohol Oxidoreductases; Cytosine; Guanine; Light; Riboflavin; Thymine; Uracil; Yeasts | 1966 |
[On the effect of pyrimidines and their precursors on the diabetogenic activity of alloxan].
Topics: Alloxan; Animals; Aspartic Acid; Barbiturates; Blood Glucose; Cytosine; Diabetes Mellitus, Experimental; Female; Liver Glycogen; Nucleic Acids; Orotic Acid; Pyrimidines; Rats; Thymine; Uracil; Uric Acid | 1966 |
[On the action mechanism of thymine-analogous cytostatics in bacteria].
Topics: Antineoplastic Agents; Bacteria; Cytosine; Lactobacillus; Pyrimidines; Thymine; Tritium; Uracil | 1966 |
[Optical properties and molecular structure of nucleic acids and their components. IV. Infrared spectra and molecular structure of uracil and its derivatives].
Topics: Chemical Phenomena; Chemistry; Deuterium; Hydrogen-Ion Concentration; Infrared Rays; Spectrophotometry; Temperature; Thymidine; Thymine; Uracil; Uridine | 1966 |
[On the experimental study of stomach ulcer in rats].
Topics: Animals; Cytosine; Male; Pyrimidines; Rats; Stomach Neoplasms; Stomach Ulcer; Thiouracil; Thymine; Uracil | 1966 |
Thymine and uracil metabolism in the epidermis.
Topics: Animals; Carbon Isotopes; Guinea Pigs; Humans; Skin; Thymidine; Thymine; Tritium; Uracil | 1967 |
The process of infection with bacteriophage phi-X-174. XI. Infectivity of the complementary strand of the replicative form.
Topics: Antimetabolites; Bromine; Centrifugation, Density Gradient; Coliphages; Deoxyribonucleases; DNA, Viral; Thymine; Ultracentrifugation; Uracil; Virulence | 1967 |
Incorporation of pyrimidines and boron analogues into brain tumour and brain tissue of mice. An approach to boron-neutron capture therapy.
Topics: Animals; Boron; Brain Neoplasms; Carbon Isotopes; DNA; Ependymoma; Mice; Neoplasms, Experimental; Nerve Tissue; Pyrimidines; RNA; Thymine; Tritium; Uracil | 1967 |
Characterization of the photodimers from DNA.
Topics: Chemical Phenomena; Chemistry; DNA; Spectrum Analysis; Thymine; Uracil | 1967 |
Separation and chain-length determination of polynucleotides by gel filtration.
Topics: Adenine; Chromatography, Gel; Cytosine; Guanine; Hydrogen-Ion Concentration; Molecular Weight; Polynucleotides; Thymine; Uracil | 1967 |
[On the effective mechanism of the photodynamic furocumarine photoreaction of psoralen-(4-14C) with DNA, RNA, homopolynucleotides and nucleosides].
Topics: Chromatography, Paper; Coumarins; DNA; Hydrogen-Ion Concentration; Protein Binding; RNA; Thymine; Uracil | 1967 |
Effect of functional group substituents on the paper chromatography of purines and pyrimidines.
Topics: Adenine; Caffeine; Chemical Phenomena; Chemistry; Chromatography, Paper; Cytosine; Guanine; Hydrogen-Ion Concentration; Nitriles; Purines; Pyrimidines; Theobromine; Theophylline; Thymine; Uracil; Water; Xanthines | 1967 |
Photodimerization of pyrimidine nucleic acid derivatives in aqueous solution and the effect of oxygen.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Light; Nucleic Acids; Nucleotides; Orotic Acid; Oxygen; Polymers; Pyrimidines; Solutions; Thymidine; Thymine; Uracil; Uridine | 1967 |
Inhibition of thymidine phosphorylase by 6-aminothymine and derivatives of 6-aminouracil.
Topics: Animals; Chromatography, Thin Layer; Glucosyltransferases; Mice; Thymine; Uracil | 1967 |
Rapid separation of thymine dimer and pyrimidines on ion-exchange paper.
Topics: Adenine; Chromatography, Paper; Cytosine; Guanine; Ion Exchange Resins; Nucleosides; Nucleotides; Pyrimidines; Thymidine; Thymine; Uracil; Uridine | 1967 |
The enzymatic mechanisms for deoxythymidine synthesis in human leukocytes. I. Substrate inhibition by thymine and activation by phosphate or arsenate.
Topics: Arsenicals; Cell-Free System; Deoxyuridine; Glucosyltransferases; Humans; Hydrogen-Ion Concentration; Kinetics; Leukocytes; Pentosephosphates; Phosphates; Thymidine; Thymine; Uracil | 1967 |
Theoretical study on the alkylation and protonation of the nucleic acid bases.
Topics: Adenine; Alkylation; Carcinogens; Chemical Phenomena; Chemistry; Cytosine; Guanine; Methylation; Mutagens; Nucleic Acids; Protons; Purines; Pyrimidines; Thermodynamics; Thymine; Uracil | 1984 |
Site of OH radical attack on dihydrouracil and some of its methyl derivatives.
Topics: Ferricyanides; Hydroxides; Hydroxyl Radical; Indicators and Reagents; Pentoxyl; Pulse Radiolysis; Radiochemistry; Tetramethylphenylenediamine; Tetranitromethane; Thymine; Uracil | 1984 |
Properties and regulation of pyrimidine catabolism in Escherichia coli.
Topics: Ammonia; Diazonium Compounds; Escherichia coli; Glutamate-Ammonia Ligase; Indicators and Reagents; Sulfanilic Acids; Thymine; Uracil | 1981 |
[Age dependency of normal and modified nucleobases in urine in correlation to growth velocity (author's transl)].
Topics: Adenine; Adolescent; Age Factors; Base Sequence; Child; Child, Preschool; Creatinine; Cytosine; Female; Growth; Guanine; Humans; Infant; Male; Mathematics; Nucleosides; Puberty; Reference Values; Thymine; Uracil | 1981 |
Determination of parameters of excited states of DNA and RNA bases by laser UV photolysis.
Topics: Adenine; Cytosine; DNA; Guanine; Lasers; Photolysis; RNA; Thymine; Ultraviolet Rays; Uracil | 1982 |
Pulse radiolysis studies of some aza analogues of nucleic acid components.
Topics: Aza Compounds; Azacitidine; Azauridine; Cytosine; Pulse Radiolysis; Thymine; Uracil | 1983 |
Pyrimidine metabolism in Tritrichomonas foetus.
Topics: Animals; Cytidine; DNA; Proteins; Pyrimidine Nucleosides; Pyrimidines; RNA; Subcellular Fractions; Thymidine; Thymidine Phosphorylase; Thymine; Tritrichomonas; Uracil; Uridine; Uridine Kinase; Uridine Phosphorylase | 1983 |
Metabolism of pyrimidine bases and nucleosides in the coryneform bacteria Brevibacterium ammoniagenes and Micrococcus luteus.
Topics: Brevibacterium; Cytidine; Cytosine; DNA, Bacterial; Micrococcus; Pentosyltransferases; Pyrimidine Nucleosides; Pyrimidine Phosphorylases; Pyrimidines; RNA, Bacterial; Thymidine; Thymine; Uracil; Uridine | 1984 |
Rapid group separations of nucleotides and related compounds of silica columns.
Topics: Acetates; Acetonitriles; Adenine; Animals; Borates; Cells, Cultured; Chromatography; Cytosine; Inosine; Liver; Nucleosides; Nucleotides; Rats; Silicon Dioxide; Thymine; Uracil | 1980 |
E.S.R. studies of free radicals derived from reaction of OH with uracil and thymine.
Topics: Chemical Phenomena; Chemistry; Computers; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen-Ion Concentration; Thymine; Uracil | 1980 |
A novel, highly modified, bacteriophage DNA in which thymine is partly replaced by a phosphoglucuronate moiety covalently bound to 5-(4',5'-dihydroxypentyl)uracil.
Topics: Bacillus subtilis; Bacteriophages; DNA, Bacterial; DNA, Viral; Glucuronates; Micrococcal Nuclease; Phosphoric Diester Hydrolases; Phosphorus Radioisotopes; Radioisotope Dilution Technique; Sugar Phosphates; Thymine; Uracil | 1981 |
Nature of the stacking of nucleic acid bases in water: a Monte Carlo simulation.
Topics: Models, Chemical; Molecular Conformation; Molecular Structure; Monte Carlo Method; Thermodynamics; Thymine; Uracil; Water | 1984 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug Synergism; Fluorouracil; Neoplasms, Experimental; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentosyltransferases; Phosphorylation; Pyrimidines; Sarcoma, Yoshida; Tegafur; Thymidine; Thymine; Uracil; Uridine | 1984 |
Uracil's uncoupling of the decarboxylation of alpha-ketoglutarate in the thymine 7-hydroxylase reaction of Neurospora crassa.
Topics: Ascorbic Acid; Carbon Dioxide; Decarboxylation; Ferrous Compounds; Hydroxylation; Ketoglutaric Acids; Mixed Function Oxygenases; Neurospora; Neurospora crassa; Succinates; Succinic Acid; Thymine; Uracil | 1981 |
Elevated urine, blood and cerebrospinal fluid levels of uracil and thymine in a child with dihydrothymine dehydrogenase deficiency.
Topics: Child; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NAD+); Female; Fibroblasts; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Purines; Pyrimidines; Thymine; Uracil | 1984 |
Photochemical exchange reactions of thymine, uracil and their nucleosides with selected amino acids.
Topics: Amino Acids; Magnetic Resonance Spectroscopy; Photochemistry; Spectrophotometry, Ultraviolet; Thymidine; Thymine; Uracil; Uridine | 1984 |
Dihydropyrimidine dehydrogenase deficiency leading to thymine-uraciluria. An inborn error of pyrimidine metabolism.
Topics: Adolescent; Child; Child, Preschool; Chromatography, Thin Layer; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Leukocytes; Male; Mass Spectrometry; Oxidoreductases; Pentoxyl; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 1984 |
Assessment of electron irradiation damage to biomolecules by electron diffraction and electron energy-loss spectroscopy.
Topics: Adenine; Amino Acids; Cysteine; Cytosine; Electrons; Methionine; Microscopy, Electron; Pyrimidinones; Spectrum Analysis; Thymine; Uracil; Valine | 1984 |
Efficient syntheses of [3-15N]uracil and [3-15N]thymine.
Topics: Ammonium Sulfate; Indicators and Reagents; Isotope Labeling; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Thymine; Uracil | 1983 |
On the nature of folic-acid-sensitive fragile sites in human chromosomes: an hypothesis.
Topics: Base Composition; Chromatin; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human; DNA; Folic Acid; Humans; Methylation; Models, Biological; Nucleoproteins; Thymine; Uracil | 1983 |
Allosteric control of pyrimidine transport in Hymenolepis diminuta: an unusual kinetic isotope effect.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Cell Membrane; Hymenolepis; Kinetics; Thymine; Uracil | 1983 |
New defects of pyrimidine metabolism.
Topics: Child, Preschool; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrimidines; Thymine; Uracil | 1984 |
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Liver; Male; Mice; Phosphorylation; Rats; Sarcoma 180; Sarcoma, Yoshida; Tegafur; Thymidine; Thymidine Phosphorylase; Thymine; Uracil; Uridine; Uridine Phosphorylase | 1980 |
Determination of 5-fluorouracil and pyrimidine bases in plasma by gas chromatography-chemical ionization-mass fragmentography.
Topics: Cytosine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Ions; Pyrimidines; Tegafur; Thymine; Uracil | 1980 |
Reactivity of the alpha-putrescinylthymine amino groups in phi W-14 deoxyribonucleic acid.
Topics: Acetic Anhydrides; Acetylation; Bacteriophages; DNA, Viral; Kinetics; Lysine; Nucleic Acid Conformation; Ornithine; Thymine; Trinitrobenzenesulfonic Acid; Uracil | 1982 |
The structures of two potential antitumor steroid--base adducts.
Topics: Antineoplastic Agents; Chemical Phenomena; Chemistry; Hydrogen Bonding; Hydroxyprogesterones; Molecular Conformation; Progesterone; Receptors, Steroid; Structure-Activity Relationship; Thymine; Uracil; X-Ray Diffraction | 1983 |
A high level of thymine replacement by 5-hydroxymethyluracil in nuclear DNA of the primitive dinoflagellate Prorocentrum micans E.
Topics: Animals; Base Composition; Centrifugation, Density Gradient; Cytosine; Dinoflagellida; DNA; Guanine; Nucleic Acid Denaturation; Pentoxyl; Thymine; Uracil | 1982 |
Uridine and uracil transport in Escherichia coli and transport-deficient mutants.
Topics: Adenine; Adenosine; Biological Transport; Escherichia coli; Guanine; Hypoxanthines; Inosine; Kinetics; Mutation; Species Specificity; Thymine; Uracil; Uridine | 1981 |
Pyrimidine metabolism in Giardia lamblia trophozoites.
Topics: Animals; Cytidine; Giardia; Pyrimidines; Thymidine; Thymidine Phosphorylase; Thymine; Uracil; Uridine; Uridine Phosphorylase | 1982 |
Pyrimidine synthesis by intracellular Toxoplasma gondii.
Topics: Amides; Animals; Aspartic Acid; Cell Line; Cricetinae; Cytosine; Glucose; Humans; Pyrazoles; Pyrimidines; Ribonucleosides; Ribose; Thymine; Toxoplasma; Uracil | 1981 |
Synthesis and interactions of poly-L-lysines containing nucleic acid bases.
Topics: Adenine; Circular Dichroism; Nucleic Acid Conformation; Optical Rotatory Dispersion; Peptides; Polylysine; Protein Conformation; Structure-Activity Relationship; Thymine; Uracil | 1980 |
5-[(Hydroxymethyl)-O-pyrophosphoryl]uracil, an intermediate in the biosynthesis of alpha-putrescinylthymine in deoxyribonucleic acid of bacteriophage phi W-14.
Topics: Bacteriophages; Cell-Free System; DNA Replication; DNA, Viral; Kinetics; Pseudomonas; Thymine; Uracil; Virus Replication | 1981 |
Degradation of pyrimidine bases in Clostridium sticklandii.
Topics: Biodegradation, Environmental; Cell-Free System; Chromatography, Thin Layer; Clostridium; NAD; NADP; Oxidation-Reduction; Thymine; Uracil | 1980 |
Analysis of pyrimidine bases in biological materials by gas chromatography-mass spectrometry.
Topics: Animals; Cytosine; Gas Chromatography-Mass Spectrometry; Mice; Mice, Nude; Pyrimidines; Thymine; Uracil | 1980 |
The reduction of thymine residues in DNA by the combined action of UV light and hypophosphite.
Topics: Circular Dichroism; DNA; DNA Damage; Kinetics; Oxidation-Reduction; Phosphinic Acids; Poly T; Pyrimidines; Quantum Theory; Radiation-Sensitizing Agents; Structure-Activity Relationship; Thymine; Ultraviolet Rays; Uracil | 1995 |
Using modified nucleotides to map the DNA determinants of the Tus-TerB complex, the protein-DNA interaction associated with termination of replication in Escherichia coli.
Topics: 2-Aminopurine; Bacterial Proteins; Base Sequence; Binding Sites; Binding, Competitive; Calorimetry; Deoxyribonucleotides; DNA Replication; DNA-Binding Proteins; DNA, Bacterial; Escherichia coli Proteins; Genes, Bacterial; Guanine; Hydrogen Bonding; Inosine; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; Structure-Activity Relationship; Terminator Regions, Genetic; Thymine; Uracil | 1995 |
Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase.
Topics: Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Mutagenesis, Site-Directed; Nevirapine; Pyridines; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Thymine; Uracil; Zidovudine | 1995 |
Combined deficiencies of NADPH- and NADH-dependent dihydropyrimidine dehydrogenases, a new finding in a family with thymine-uraciluria.
Topics: Child, Preschool; Dihydrouracil Dehydrogenase (NADP); Fibroblasts; Heterozygote; Humans; Leukocytes; Male; NAD; NADP; Oxidoreductases; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 1995 |
Oxidation of thymine to 5-formyluracil in DNA: mechanisms of formation, structural implications, and base excision by human cell free extracts.
Topics: Base Composition; Cell Extracts; Chromatography, High Pressure Liquid; DNA; DNA Glycosylases; DNA Repair; Humans; Kinetics; Leukocytes, Mononuclear; Molecular Structure; Mutagenesis; N-Glycosyl Hydrolases; Oxidation-Reduction; Pentoxyl; Photolysis; Thymine; Ultraviolet Rays; Uracil; Vitamin K | 1995 |
Heterogeneity of symptomatology in two male siblings with thymine uraciluria.
Topics: Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant, Newborn; Language Development Disorders; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 1995 |
Base excision repair of U:G mismatches at a mutational hotspot in the p53 gene is more efficient than base excision repair of T:G mismatches in extracts of human colon tumors.
Topics: Base Sequence; Colonic Neoplasms; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; Endodeoxyribonucleases; Genes, p53; Guanine; HeLa Cells; Humans; Molecular Sequence Data; N-Glycosyl Hydrolases; Point Mutation; Thymine; Uracil; Uracil-DNA Glycosidase | 1995 |
Dihydropyrimidinuria: the first case in Japan.
Topics: Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Japan; Male; Mass Screening; Pilot Projects; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Thymine; Uracil | 1994 |
HpaII methyltransferase is mutagenic in Escherichia coli.
Topics: 5-Methylcytosine; Base Sequence; Cytosine; DNA Repair; DNA-Cytosine Methylases; Escherichia coli; Haemophilus; Molecular Sequence Data; Mutagenesis; Thymine; Uracil | 1995 |
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging.
Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA Damage; DNA, Neoplasm; Gas Chromatography-Mass Spectrometry; Guanine; Hydrolysis; Liver; Liver Neoplasms, Experimental; Lung; Lung Neoplasms; Male; Methylamines; Nitrates; Oxidation-Reduction; Pyrimidines; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thymine; Uracil | 1995 |
Different effects of base analog substitutions in BamHI restriction site on recognition by BamHI endonuclease and BamHI methylase.
Topics: Base Sequence; Binding Sites; Bromouracil; Deoxyribonuclease BamHI; DNA-Cytosine Methylases; Guanine; Inosine; Kinetics; Molecular Sequence Data; Oligonucleotides; Structure-Activity Relationship; Substrate Specificity; Thymine; Uracil | 1995 |
Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea.
Topics: Base Sequence; Cells, Cultured; Child, Preschool; Dihydrouracil Dehydrogenase (NADP); Exons; Female; Fibroblasts; Genotype; Humans; Male; Molecular Sequence Data; Netherlands; Oxidoreductases; Pedigree; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Purine-Pyrimidine Metabolism, Inborn Errors; RNA, Messenger; Sequence Deletion; Thymine; Uracil | 1995 |
The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Topics: Amino Acid Sequence; Binding Sites; Catalysis; Computer Graphics; Crystallography, X-Ray; DNA Glycosylases; DNA Repair; Herpesvirus 1, Human; Humans; Models, Molecular; Molecular Sequence Data; N-Glycosyl Hydrolases; Protein Structure, Secondary; Structure-Activity Relationship; Substrate Specificity; Thymine; Uracil; Uracil-DNA Glycosidase | 1995 |
The influence of packing on free radical yields in crystalline nucleic acids: the pyrimidine bases.
Topics: Crystallization; Cytosine; Electron Spin Resonance Spectroscopy; Free Radicals; Pyrimidines; Thymine; Uracil | 1994 |
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the AlkA enzyme in Escherichia coli.
Topics: Adenine; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; DNA Glycosylases; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genes, Bacterial; Kinetics; N-Glycosyl Hydrolases; Oxidation-Reduction; Thymine; Uracil | 1994 |
Multiple chromosomes in bacteria: structure and function of chromosome II of Rhodobacter sphaeroides 2.4.1T.
Topics: 4-Aminobenzoic Acid; Base Sequence; Chromosome Mapping; Chromosomes, Bacterial; Cloning, Molecular; Cosmids; DNA Mutational Analysis; Genetic Complementation Test; Genome, Bacterial; Histidine; Hydroxybenzoates; Molecular Sequence Data; Mutagenesis, Insertional; Restriction Mapping; Rhodobacter sphaeroides; Serine; Thymine; Uracil | 1994 |
Energetic basis for structural preferences in 5/6-hydroxy-5,6-dihydropyrimidines: products of ionizing and ultraviolet radiation action on DNA bases.
Topics: Calorimetry; Cytosine; DNA; Models, Molecular; Molecular Conformation; Molecular Structure; Pyrimidines; Radiation, Ionizing; Stereoisomerism; Thymine; Ultraviolet Rays; Uracil | 1994 |
cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 1; Cricetinae; Dihydrouracil Dehydrogenase (NADP); DNA, Complementary; Fluorouracil; Humans; Hybrid Cells; Metabolism, Inborn Errors; Mice; Molecular Sequence Data; Oxidoreductases; Recombinant Proteins; Swine; Thymine; Uracil | 1994 |
Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells.
Topics: Base Composition; Base Sequence; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Repair; Endodeoxyribonucleases; HeLa Cells; Humans; Molecular Sequence Data; Substrate Specificity; Thymine; Uracil | 1994 |
Contributions of the thymine methyl group to the specific recognition of poly- and mononucleotides: an analysis of the relative free energies of solvation of thymine and uracil.
Topics: Adenine; Base Composition; Calorimetry; DNA; Molecular Structure; Nucleotides; Polynucleotides; Proteins; Solutions; Thermodynamics; Thymine; Uracil | 1994 |
A non-heme iron protein with heme tendencies: an investigation of the substrate specificity of thymine hydroxylase.
Topics: Amino Acid Sequence; Carboxylic Acids; Catalysis; Heme; Hydroxylation; Iron; Kinetics; Metalloproteins; Mixed Function Oxygenases; Molecular Sequence Data; Neurospora crassa; Nonheme Iron Proteins; Oxidation-Reduction; Rhodotorula; Stereoisomerism; Substrate Specificity; Thymine; Uracil | 1993 |
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Lymphoma, Large B-Cell, Diffuse; Mice; Molecular Structure; Neoplasm Transplantation; Structure-Activity Relationship; Thymine; Tumor Cells, Cultured; Uracil | 1993 |
Nucleosides and nucleotides. 123. Synthesis of 1-(2-deoxy-2-isocyano-beta-D-arabinofuranosyl)cytosine and related nucleosides as potential antitumor agents.
Topics: Animals; Antineoplastic Agents; Cytarabine; Deoxycytidine; Drug Stability; Humans; Isocyanates; Leukemia L1210; Lung Neoplasms; Mice; Molecular Structure; Mouth Neoplasms; Stomach Neoplasms; Thymine; Tumor Cells, Cultured; Uracil | 1993 |
1H NMR studies of gamma-irradiated polynucleotides and DNA in N2O-saturated aqueous solutions: release of undamaged and modified bases.
Topics: Adenine; Cobalt Radioisotopes; Cytosine; DNA Damage; DNA, Single-Stranded; Gamma Rays; Magnetic Resonance Spectroscopy; Nitrous Oxide; Polyribonucleotides; Solutions; Thymine; Uracil; Water | 1993 |
Cytosine deamination in mismatched base pairs.
Topics: Bacteriophage M13; Base Composition; Base Sequence; beta-Galactosidase; Cytosine; Deamination; DNA, Circular; DNA, Single-Stranded; DNA, Viral; Escherichia coli; Genes, Bacterial; Kinetics; Nucleic Acid Heteroduplexes; Thermodynamics; Thymine; Transfection; Uracil | 1993 |
Uracil-DNA glycosylase as a probe for protein--DNA interactions.
Topics: Base Sequence; Binding Sites; Deoxyribonuclease I; DNA; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Lac Operon; Molecular Sequence Data; N-Glycosyl Hydrolases; Polymerase Chain Reaction; Repressor Proteins; Thymine; Uracil; Uracil-DNA Glycosidase; Viral Proteins; Viral Regulatory and Accessory Proteins | 1993 |
Surface-enhanced Raman spectroscopic detection of CO2-(3), SO2-(3), and nucleic acid bases using polyvinyl alcohol film doped with Ag fine particles.
Topics: Adenine; Carbonates; Cytosine; DNA; Guanine; Membranes, Artificial; Particle Size; Polyvinyl Alcohol; Scattering, Radiation; Silver; Spectrum Analysis, Raman; Sulfites; Surface Properties; Thymine; Uracil | 1993 |
DNA mismatch repair and DNA methylation in adult brain neurons.
Topics: 5-Methylcytosine; Animals; Base Composition; Base Sequence; Brain; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Repair; Liver; Methylation; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Organ Specificity; Rats; Thymine; Thymus Gland; Uracil | 1996 |
The problem with pyrimidines.
Topics: Amination; Bacillus Phages; Bacillus subtilis; Base Composition; Cytosine; DNA; DNA Glycosylases; Models, Biological; Models, Molecular; N-Glycosyl Hydrolases; Pyrophosphatases; Thymine; Uracil; Uracil-DNA Glycosidase | 1996 |
Synthesis and biological evaluation of1',2'-seconucleo-5'- phosphonates.
Topics: Adenine; Adenoviruses, Human; Antiviral Agents; Cystine; HIV; Molecular Structure; Nucleotides; Organophosphonates; Organophosphorus Compounds; RNA Viruses; Thymine; Uracil | 1996 |
Synthesis and potent anti-HIV-1 activity of novel 6-benzyluracil analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.
Topics: Alkylation; Antiviral Agents; Cell Division; Drug Design; HIV-1; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship; T-Lymphocytes; Thymine; Uracil; Virus Replication | 1996 |
Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC-->TT transitions.
Topics: Bacteriophage M13; Base Composition; Base Sequence; Cytosine; Deoxyribodipyrimidine Photo-Lyase; DNA Glycosylases; DNA, Viral; Escherichia coli; Kinetics; Lac Operon; Models, Chemical; Molecular Sequence Data; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Pyrimidine Dimers; Recombinant Proteins; Thymine; Transfection; Ultraviolet Rays; Uracil; Uracil-DNA Glycosidase | 1996 |
The paradoxical influence of thymine analogues on restriction endonuclease cleavage of oligodeoxynucleotides.
Topics: Binding Sites; Deoxyribonucleases, Type II Site-Specific; Electrophoresis, Polyacrylamide Gel; Fluoresceins; Fluorescence; Fluorescent Dyes; Hydrolysis; Kinetics; Molecular Structure; Oligodeoxyribonucleotides; Pentoxyl; Thymine; Uracil | 1996 |
A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase.
Topics: Amino Acid Sequence; Animals; Deamination; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; Drosophila melanogaster; Endodeoxyribonucleases; Escherichia coli; Humans; Mice; Molecular Sequence Data; N-Glycosyl Hydrolases; Recombinant Proteins; Sequence Deletion; Sequence Homology, Amino Acid; Serratia marcescens; Thymine; Thymine DNA Glycosylase; Uracil; Uracil-DNA Glycosidase | 1996 |
Identification of a Tus protein segment that photo-cross-links with TerB DNA and elucidation of the role of certain thymine methyl groups in the Tus-TerB complex using halogenated uracil analogues.
Topics: Bacterial Proteins; Bromodeoxyuridine; DNA; DNA-Binding Proteins; Escherichia coli; Escherichia coli Proteins; Glutamates; Half-Life; Idoxuridine; Thymine; Uracil | 1996 |
Expulsion of uracil and thymine from the yeast Saccharomyces cerevisiae: contrasting responses to changes in the proton electrochemical gradient.
Topics: Adenosine Triphosphate; Biological Transport, Active; Energy Metabolism; Glucose; Hydrogen-Ion Concentration; Models, Biological; Potassium; Proton-Motive Force; Saccharomyces cerevisiae; Thymine; Uracil | 1997 |
Secondary radical attack on DNA nucleotides: reaction by addition to DNA bases and abstraction from sugars.
Topics: Adenine; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; DNA; Electron Spin Resonance Spectroscopy; Free Radicals; Gamma Rays; Guanine; Iodoacetamide; Kinetics; Molecular Structure; Oligodeoxyribonucleotides; Thermodynamics; Thymidine Monophosphate; Thymine; Uracil | 1997 |
Lack of correlation between phenotype and genotype for the polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin.
Topics: Child, Preschool; Dihydrouracil Dehydrogenase (NADP); Genotype; Humans; Male; Molecular Sequence Data; Mutation; Oxidoreductases; Pakistan; Phenotype; Polymorphism, Restriction Fragment Length; Purine-Pyrimidine Metabolism, Inborn Errors; RNA Splicing; Sequence Tagged Sites; Thymine; Uracil | 1997 |
Site-specific crosslinking of mammalian U11 and u6atac to the 5' splice site of an AT-AC intron.
Topics: Adenine; Base Sequence; Binding Sites; Cell Nucleus; Cross-Linking Reagents; Cytosine; HeLa Cells; Humans; Introns; Point Mutation; Polymerase Chain Reaction; Ribonucleoprotein, U4-U6 Small Nuclear; Ribonucleoproteins, Small Nuclear; RNA Splicing; Spliceosomes; Substrate Specificity; Thymine; Ultraviolet Rays; Uracil | 1997 |
Dam methyltransferase from Escherichia coli: kinetic studies using modified DNA oligomers: nonmethylated substrates.
Topics: 2-Aminopurine; Adenine; Base Sequence; DNA Methylation; DNA Probes; DNA, Bacterial; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Guanine; Hypoxanthine; Kinetics; Molecular Sequence Data; Nucleic Acid Heteroduplexes; Oligonucleotide Probes; Site-Specific DNA-Methyltransferase (Adenine-Specific); Software; Substrate Specificity; Temperature; Thermodynamics; Thymine; Uracil | 1997 |
Replication of DNA templates containing 5-formyluracil, a major oxidative lesion of thymine in DNA.
Topics: Base Composition; Deoxycytidine Monophosphate; DNA; DNA Polymerase I; DNA Primers; DNA Replication; Exodeoxyribonuclease V; Exodeoxyribonucleases; Mutagens; Oxidation-Reduction; Templates, Genetic; Thymine; Uracil | 1997 |
Development and survival of Drosophila melanogaster fed a diet containing pyrimidine analogs.
Topics: Animals; Bromouracil; Cytosine; Diet; Drosophila melanogaster; Female; Larva; Male; Orotic Acid; Pupa; Pyrimidines; Thymine; Uracil; Uridine Monophosphate | 1997 |
Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones.
Topics: Alkylation; Anti-HIV Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Magnetic Resonance Spectroscopy; Mesylates; Pyrimidines; Pyrimidinones; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thiazoles; Thymine; Uracil; Virus Replication | 1998 |
Enzymatic processing of uracil glycol, a major oxidative product of DNA cytosine.
Topics: Adenosine Triphosphate; Base Composition; Base Sequence; Cytosine; Deoxyadenine Nucleotides; DNA; DNA Damage; DNA Polymerase I; DNA Primers; DNA Repair; Escherichia coli; Kinetics; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oxidation-Reduction; Templates, Genetic; Thymine; Uracil | 1998 |
Michael addition reactions of some nucleobases to 1-(4,6-O-benzylidene-2,3-didehydro-2,3-dideoxy-3-nitro-beta-D- hexopyran osyl) uracil.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Indicators and Reagents; Molecular Structure; Nucleosides; Thymine; Uracil; Uridine | 1997 |
Clinical and biochemical aspects of dihydropyrimidinase deficiency.
Topics: Amidohydrolases; Biomarkers; Humans; Purine-Pyrimidine Metabolism, Inborn Errors; Reference Values; Thymine; Uracil | 1998 |
Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil.
Topics: Animals; Biological Availability; Biotransformation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Intestinal Mucosa; Kinetics; Liver; Mice; Oxidoreductases; Rats; Species Specificity; Thymidine; Thymine; Uracil | 1998 |
The electron affinities of the radicals formed by the loss of an aromatic hydrogen atom from adenine, guanine, cytosine, uracil, and thymine.
Topics: Adenine; Cytosine; Electrochemistry; Free Radicals; Guanine; Hydrogen; Mass Spectrometry; Purines; Pyrimidines; Thermodynamics; Thymine; Uracil | 1998 |
Oxidative damage to proteins, lipids, and DNA in cortical brain regions from patients with dementia with Lewy bodies.
Topics: Adenine; Aged; Aged, 80 and over; Alzheimer Disease; Brain Chemistry; Cerebral Cortex; Cytosine; DNA; Guanine; Humans; Hydantoins; Hypoxanthine; Lewy Bodies; Lipid Peroxidation; Middle Aged; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Thymine; Uracil; Xanthine | 1998 |
[A case of gastric cancer with decreased dihydropyrimidine dehydrogenase activity].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Oxidoreductases; Pyrimidines; Stomach Neoplasms; Thymine; Uracil | 1998 |
Kinetics of the action of thymine DNA glycosylase.
Topics: Base Composition; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA-Binding Proteins; Endodeoxyribonucleases; Escherichia coli; Humans; Kinetics; Thioguanine; Thymine; Uracil | 1998 |
Clinical variability in three Danish patients with dihydropyrimidine dehydrogenase deficiency all homozygous for the same mutation.
Topics: Cell Line, Transformed; Cells, Cultured; Child; Child, Preschool; Dihydrouracil Dehydrogenase (NADP); Female; Homozygote; Humans; Infant; Male; Mutation; Netherlands; Oxidoreductases; Pentoxyl; Thymine; Uracil | 1998 |
Dark and photochemical interactions of dimethyltetrahydrobenzoangelicin with DNA.
Topics: Darkness; DNA; Furocoumarins; Light; Models, Molecular; Photochemistry; Solubility; Thymine; Uracil | 1998 |
Population and family studies of dihydropyrimidinuria: prevalence, inheritance mode, and risk of fluorouracil toxicity.
Topics: Adult; Amidohydrolases; Child; Child, Preschool; Female; Fluorouracil; Genes, Recessive; Homozygote; Humans; Infant; Japan; Male; Metabolism, Inborn Errors; Nuclear Family; Prevalence; Pyrimidines; Risk; Thymine; Uracil | 1998 |
Characterization of the human dihydropyrimidine dehydrogenase gene.
Topics: Alleles; Cloning, Molecular; Dihydrouracil Dehydrogenase (NADP); Exons; Fluorouracil; Gene Dosage; Humans; Introns; Leukocytes; Neoplasm Proteins; Oxidoreductases; Point Mutation; Polymerase Chain Reaction; Restriction Mapping; RNA Splicing; RNA, Messenger; Thymine; Uracil | 1998 |
On the use of ultraviolet resonance Raman intensities to elaborate molecular force fields: application to nucleic acid bases and aromatic amino acid residues models.
Topics: Amino Acids; Base Pairing; Cresols; Cytosine; Electromagnetic Fields; Electrons; Guanine; Hydrocarbons, Aromatic; Imidazoles; Indoles; Molecular Structure; Nucleic Acids; Quantum Theory; Spectrum Analysis, Raman; Statistics as Topic; Thymine; Ultraviolet Rays; Uracil | 1998 |
Investigations on the influence of cisplatin on the antitumor effect of novel phosphonate derivatives of uracil and thymine.
Topics: Animals; Antineoplastic Agents; Cisplatin; Drug Interactions; Leukemia L1210; Male; Mice; Organophosphonates; Thymine; Tumor Cells, Cultured; Uracil | 1998 |
Excision of products of oxidative DNA base damage by human NTH1 protein.
Topics: Barbiturates; Cytosine; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; Kinetics; Oxidation-Reduction; Substrate Specificity; Thymine; Uracil | 1999 |
Synthesis and anticancer evaluation of certain alpha-methylene-gamma-(4-substituted phenyl)-gamma-butyrolactone bearing thymine, uracil, and 5-bromouracil.
Topics: 4-Butyrolactone; Alkylating Agents; Antineoplastic Agents; Bromouracil; Thymine; Tumor Cells, Cultured; Uracil | 1999 |
Classification of organic molecules to obtain electron affinities from half-wave reduction potentials: cytosine, uracil, thymine, guanine and adenine.
Topics: Adenine; Algorithms; Cytosine; Electrons; Guanine; Organic Chemicals; Oxidation-Reduction; Riboflavin; Solvents; Thymine; Uracil; Vitamin A; Vitamin E | 1999 |
A study of the hydration of deoxydinucleoside monophosphates containing thymine, uracil and its 5-halogen derivatives: Monte Carlo simulation.
Topics: Dinucleoside Phosphates; Kinetics; Monte Carlo Method; Nucleic Acid Conformation; Thymine; Uracil; Water | 1999 |
Specific binding of human MSH2.MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine- or uracil-containing UV light photoproducts opposite mismatched bases.
Topics: Base Pair Mismatch; Dimerization; DNA; DNA Repair; DNA-Binding Proteins; Humans; Models, Genetic; Mutagenesis; MutS Homolog 2 Protein; Protein Binding; Proto-Oncogene Proteins; Pyrimidine Dimers; Thymine; Ultraviolet Rays; Uracil | 1999 |
Enzymatic repair of 5-formyluracil. I. Excision of 5-formyluracil site-specifically incorporated into oligonucleotide substrates by alka protein (Escherichia coli 3-methyladenine DNA glycosylase II).
Topics: Adenine; Base Pair Mismatch; DNA Damage; DNA Glycosylases; DNA Repair; Escherichia coli; Guanine; Kinetics; Magnetic Resonance Spectroscopy; Methylnitronitrosoguanidine; Molecular Structure; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Pentoxyl; Substrate Specificity; Thymine; Uracil | 1999 |
Enzymatic repair of 5-formyluracil. II. Mismatch formation between 5-formyluracil and guanine during dna replication and its recognition by two proteins involved in base excision repair (AlkA) and mismatch repair (MutS).
Topics: Adenine; Adenosine Triphosphatases; Bacterial Proteins; Base Pair Mismatch; DNA Glycosylases; DNA Repair; DNA Replication; DNA-Binding Proteins; Escherichia coli Proteins; Guanine; Kinetics; MutS DNA Mismatch-Binding Protein; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Thymine; Uracil | 1999 |
The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites.
Topics: Amino Acid Sequence; Animals; Deoxyribonuclease (Pyrimidine Dimer); Dinucleoside Phosphates; DNA; DNA Methylation; DNA Repair; Endodeoxyribonucleases; Humans; Mice; Molecular Sequence Data; Nucleic Acid Heteroduplexes; Sequence Homology, Amino Acid; Substrate Specificity; Thymine; Uracil | 1999 |
Crystal structure of a thwarted mismatch glycosylase DNA repair complex.
Topics: Base Pair Mismatch; Catalysis; Crystallography, X-Ray; Cytosine; Deoxyribonuclease (Pyrimidine Dimer); DNA Repair; Endodeoxyribonucleases; Escherichia coli; Models, Molecular; N-Glycosyl Hydrolases; Protein Binding; Protein Conformation; Thymine; Thymine DNA Glycosylase; Uracil | 1999 |
Thermodynamic, kinetic and structural studies on the ternary palladium(II) complexes of thioether ligands.
Topics: Calorimetry; Dipeptides; Glycylglycine; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Methionine; Palladium; Potentiometry; Sulfides; Thermodynamics; Thymine; Uracil; Uridine | 2000 |
Infrared spectroscopy of the photo- and radiobiology of DNA bases and their derivatives.
Topics: Adenine; Cytosine; Guanine; Radiation, Ionizing; Spectrophotometry, Infrared; Thymine; Ultraviolet Rays; Uracil | 1974 |
Identification of repair enzymes for 5-formyluracil in DNA. Nth, Nei, and MutM proteins of Escherichia coli.
Topics: Borohydrides; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Glycosylases; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Electrophoresis, Polyacrylamide Gel; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Glutathione Transferase; Mutagenesis, Site-Directed; Mutation; N-Glycosyl Hydrolases; Oligonucleotides; Plasmids; Radiation, Ionizing; Thymine; Uracil | 2000 |
Tandemly repeated DNA is a target for the partial replacement of thymine by beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.
Topics: Animals; DNA Transposable Elements; DNA, Protozoan; DNA, Ribosomal; Genes, Protozoan; Genes, rRNA; Glucosides; RNA, Ribosomal, 5S; RNA, Spliced Leader; Tandem Repeat Sequences; Telomere; Thymine; Trypanosoma brucei brucei; Uracil | 2000 |
Comparison of substrate specificities of Escherichia coli endonuclease III and its mouse homologue (mNTH1) using defined oligonucleotide substrates.
Topics: Animals; Base Pairing; Borohydrides; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; Endodeoxyribonucleases; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Mice; Oligonucleotides; Oligopeptides; Schiff Bases; Sequence Homology, Amino Acid; Stereoisomerism; Substrate Specificity; Thymine; Uracil; Urea | 2000 |
Footprinting studies of specific complexes formed by RepA, a replication initiator of plasmid pCU1, and its binding site.
Topics: Bacterial Proteins; Binding Sites; Chromosome Mapping; DNA Footprinting; DNA Helicases; DNA Replication; DNA-Binding Proteins; DNA, Bacterial; Phosphates; Plasmids; Polymerase Chain Reaction; Protein Binding; Proteins; Replication Origin; Thymine; Trans-Activators; Uracil | 2000 |
Beta-alanine synthase, an enzyme involved in catabolism of uracil and thymine.
Topics: Amidohydrolases; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Isoelectric Focusing; Thymine; Uracil | 2000 |
Synthesis and monitored selection of 5'-nucleobase-capped oligodeoxyribonucleotides.
Topics: Acetic Acid; Base Sequence; Genetic Engineering; Kinetics; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nuclease Protection Assays; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Phosphodiesterase I; Phosphoric Diester Hydrolases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Temperature; Thermodynamics; Thymine; Ultraviolet Rays; Uracil | 2000 |
Defects in pyrimidine degradation identified by HPLC-electrospray tandem mass spectrometry of urine specimens or urine-soaked filter paper strips.
Topics: Chromatography, High Pressure Liquid; Humans; Paper; Pyrimidines; Reproducibility of Results; Specimen Handling; Spectrometry, Mass, Electrospray Ionization; Thymine; Uracil | 2000 |
Differential adsorption of nucleic acid bases: Relevance to the origin of life.
Topics: Adenine; Adsorption; Cytosine; Guanine; Hypoxanthine; Origin of Life; Purines; Pyrimidines; RNA; Surface Properties; Thymine; Uracil | 2001 |
An electrochemical evidence of free radicals formation from flutamide and its reactivity with endo/xenobiotics of pharmacological relevance.
Topics: Acetylcysteine; Adenine; Androgen Antagonists; Cysteamine; Electrochemistry; Flutamide; Free Radical Scavengers; Free Radicals; Glutathione; Kinetics; Thermodynamics; Thymine; Uracil; Xenobiotics | 2001 |
[Polymethylene derivatives of nucleic bases with omega-functional groups. Pyrimidine derivatives].
Topics: Cytosine; DNA Topoisomerases, Type I; Enzyme Inhibitors; HIV Reverse Transcriptase; Humans; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine; Topoisomerase I Inhibitors; Uracil | 2000 |
Low-energy (5-40 eV) electron-stimulated desorption of anions from physisorbed DNA bases.
Topics: Adenine; Adsorption; Anions; Cytosine; DNA; DNA Damage; Electrons; Free Radicals; Guanine; Heterocyclic Compounds; Mass Spectrometry; Powders; Thymine; Uracil | 2001 |
Oxidation of thymine to 5-formyluracil in DNA promotes misincorporation of dGMP and subsequent elongation of a mismatched primer terminus by DNA polymerase.
Topics: Base Pair Mismatch; Base Sequence; Deoxyguanine Nucleotides; DNA; DNA Polymerase I; DNA Repair; DNA Replication; Escherichia coli; Kinetics; Oligodeoxyribonucleotides; Oxidation-Reduction; Templates, Genetic; Thymine; Uracil | 2001 |
Even-odd alternation in mass spectrum of thymine and uracil clusters: evidence of intracluster photodimerization.
Topics: Dimerization; DNA; Mass Spectrometry; Mutagenesis; Photochemistry; Photons; Thymine; Ultraviolet Rays; Uracil | 2001 |
Rapid detection of a common dihydropyrimidine dehydrogenase mutation associated with 5-fluorouracil toxicity and congenital thymine uraciluria using fluorogenic hybridization probes.
Topics: Alleles; Antimetabolites; Dihydrouracil Dehydrogenase (NADP); Fluorescent Dyes; Fluorouracil; Genotype; Humans; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Oxidoreductases; Polymorphism, Genetic; Sequence Analysis, DNA; Temperature; Thymine; Uracil | 2001 |
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.
Topics: Adult; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Exons; Fatal Outcome; Female; Fibroblasts; Fluorouracil; Gene Frequency; Humans; Leukocytes, Mononuclear; Mutation; Oxidoreductases; Polymorphism, Restriction Fragment Length; Thymine; Uracil | 2001 |
Potential derived point charge model study of electrostatic interaction energies in some complexes of water with uracil, thymine, and cytosine.
Topics: Algorithms; Cytosine; Formamides; Hydrogen Bonding; Mathematics; Methane; Static Electricity; Thymine; Uracil; Water | 1984 |
The contribution of the methyl groups on thymine bases to binding specificity and affinity by alanine-rich mutants of the bZIP motif.
Topics: Alanine; Amino Acid Motifs; Amino Acid Substitution; Basic-Leucine Zipper Transcription Factors; Binding Sites; DNA; DNA-Binding Proteins; Fluorescence Polarization; G-Box Binding Factors; Mutation; Protein Binding; Thermodynamics; Thymine; Titrimetry; Transcription Factors; Uracil; Yeasts | 2001 |
Hydration heat capacity of nucleic acid constituents determined from the random network model.
Topics: Adenine; Cysteine; Deoxyribose; Guanine; Hot Temperature; Hydrogen Bonding; Models, Chemical; Neural Networks, Computer; Nucleic Acids; Phosphates; Ribose; Thermodynamics; Thymine; Uracil; Water | 2001 |
Bond energies and attachments sites of sodium and potassium cations to DNA and RNA nucleic acid bases in the gas phase.
Topics: Adenine; Cations; Cytosine; DNA; Guanine; Models, Chemical; Models, Molecular; Potassium; RNA; Sodium; Thermodynamics; Thymine; Uracil | 2001 |
Determination of active site residues in Escherichia coli endonuclease VIII.
Topics: Amino Acid Sequence; Aspartic Acid; Binding Sites; Deoxyribonuclease (Pyrimidine Dimer); DNA Primers; Dose-Response Relationship, Drug; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Kinetics; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxygen; Plasmids; Proline; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Thymine; Uracil | 2002 |
Pyrimidine base catabolism in Pseudomonas putida biotype B.
Topics: Carbon; Culture Media; Glucose; NAD; NADP; Oxidation-Reduction; Pseudomonas putida; Succinates; Thymine; Uracil | 2001 |
The kinetics of hypoxanthine transport across the perfused choroid plexus of the sheep.
Topics: Adenine; Allopurinol; Animals; Binding, Competitive; Biological Transport; Carbon Radioisotopes; Choroid Plexus; Dose-Response Relationship, Drug; Hypoxanthine; In Vitro Techniques; Mannitol; Perfusion; Sheep; Sodium; Thioinosine; Thymine; Tritium; Uracil; Xanthine Oxidase | 2002 |
A solid-state (17)O nuclear magnetic resonance study of nucleic acid bases.
Topics: Crystallography, X-Ray; Cytosine; Guanine; Isotope Labeling; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Oxygen Isotopes; Thymine; Uracil | 2002 |
Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: the protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5' side.
Topics: Archaeal Proteins; Crystallography, X-Ray; DNA; DNA Adducts; DNA-Binding Proteins; Hydrogen; Models, Molecular; Nucleic Acid Conformation; Photochemistry; Protein Conformation; Solutions; Sulfolobus; Thymine; Uracil | 2002 |
Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure.
Topics: Age of Onset; Amino Acids; Animals; Cells, Cultured; Child, Preschool; Crystallography, X-Ray; Dihydrouracil Dehydrogenase (NADP); Electron Transport; Exons; Fibroblasts; Fluorouracil; Gene Deletion; Genotype; Granulocytes; Humans; Infant; Infant, Newborn; Intellectual Disability; Leukocytes, Mononuclear; Models, Molecular; Motor Skills Disorders; Mutation; Mutation, Missense; Oxidoreductases; Phenotype; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Pyrimidines; Swine; Thymine; Uracil | 2002 |
Comparative study of permanganate oxidation reactions of nucleotide bases by spectroscopy.
Topics: Adenine; Cytosine; Guanine; Kinetics; Manganese Compounds; Methods; Oxidation-Reduction; Oxides; Potassium Permanganate; Purines; Pyrimidines; Spectrum Analysis; Thymine; Uracil | 2002 |
5-Methyldeoxycytidine monophosphate deaminase and 5-methylcytidyl-DNA deaminase activities are present in human mature sperm cells.
Topics: Aminohydrolases; Cytidine; Deoxycytidine Monophosphate; DNA; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Male; Molecular Weight; Oligonucleotides; Spermatozoa; Substrate Specificity; Thymine; Uracil | 2002 |
Asymmetric synthesis of 4'-ethoxy-2',3'-didehydro-2',3'-dideoxynucleosides by palladium-catalyzed kinetic discrimination between the corresponding diastereoisomeric lactol acetates.
Topics: Acetates; Adenine; Alkylation; Catalysis; Chemistry, Organic; Chromatography, Thin Layer; Cytosine; Dideoxynucleosides; Kinetics; Magnetic Resonance Spectroscopy; Molecular Structure; Palladium; Stereoisomerism; Thymine; Uracil | 2002 |
Endogenous DNA lesions can inhibit the binding of the AP-1 (c-Jun) transcription factor.
Topics: Adenine; Base Pair Mismatch; Binding, Competitive; Cytosine; DNA Damage; DNA Glycosylases; DNA-Binding Proteins; Humans; N-Glycosyl Hydrolases; Nucleic Acid Heteroduplexes; Oligonucleotides; Pentoxyl; Protein Binding; Proto-Oncogene Proteins c-jun; Thymine; Transcription Factor AP-1; Uracil; Uracil-DNA Glycosidase | 2002 |
Development and characterization of a monoclonal antibody with cross-reactivity towards uracil and thymine, and its potential use in screening patients treated with 5-fluorouracil for possible risks.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Contraindications; Cross Reactions; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Humans; Hybridomas; Mice; Mice, Inbred BALB C; Oxidoreductases; Pyrimidines; Risk Factors; Thymine; Uracil | 2002 |
Pyrazolylborate-zinc-nucleobase-complexes, 2:(1) preparations and structures of Tp(Cum,Me)Zn and Tp(Ph,Me)Zn complexes.
Topics: Adenine; Borates; Cytosine; Guanine; Hydrogen Bonding; Hypoxanthines; Molecular Structure; Nucleosides; Organometallic Compounds; Purines; Pyrazoles; Pyrimidines; Spectrophotometry, Infrared; Thymine; Uracil; Xanthines; Zinc | 2002 |
Influence of local duplex stability and N6-methyladenine on uracil recognition by mismatch-specific uracil-DNA glycosylase (Mug).
Topics: Adenine; Base Composition; Base Pair Mismatch; Base Sequence; DNA; DNA Glycosylases; DNA Repair; Drug Stability; Escherichia coli; N-Glycosyl Hydrolases; Nucleic Acid Denaturation; Oligonucleotides; Phosphorus Isotopes; Substrate Specificity; Temperature; Thymine; Uracil; Uracil-DNA Glycosidase | 2002 |
Interaction of cyclic cytosine-, guanine-, thymine-, uracil- and mixed guanine-cytosine base tetrads with K+, Na+ and Li+ ions -- a density functional study.
Topics: Algorithms; Base Pairing; Cations, Monovalent; Cytosine; Guanine; Hydrogen Bonding; Lithium; Models, Chemical; Models, Molecular; Molecular Conformation; Potassium; Sodium; Static Electricity; Thermodynamics; Thymine; Uracil | 2003 |
[Separation and determination of purine bases and pyrimidine bases from nucleic acid hydrolysis by HPLC on BDS column].
Topics: Adenine; Chromatography, High Pressure Liquid; Cytosine; Guanine; Hypoxanthine; Nucleic Acids; Purines; Pyrimidines; Thymine; Uracil; Yeasts | 2000 |
The thermodynamic contribution of the 5-methyl group of thymine in the two- and three-stranded complexes formed by poly(dU) and poly(dT) with poly(dA).
Topics: Adenine; Calorimetry, Differential Scanning; Circular Dichroism; Nucleic Acid Conformation; Poly A; Poly T; Polydeoxyribonucleotides; Salts; Thermodynamics; Thymine; Uracil | 2003 |
Reactivity of substituted charged phenyl radicals toward components of nucleic acids.
Topics: Adenine; Benzene Derivatives; Biphenyl Compounds; Free Radicals; Gases; Nucleic Acids; Thermodynamics; Thymine; Uracil | 2003 |
Diagnosis of dihydropyrimidine dehydrogenase deficiency in a neonate with thymine-uraciluria.
Topics: Dihydrouracil Dehydrogenase (NADP); Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Male; Oxidoreductases; Point Mutation; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Seizures; Thymine; Uracil | 2003 |
Free energy calculations for the relative binding affinity between DNA and lambda-repressor.
Topics: Binding Sites; Computer Simulation; DNA; DNA-Binding Proteins; Mathematical Computing; Protein Binding; Repressor Proteins; Thymine; Uracil; Viral Proteins; Viral Regulatory and Accessory Proteins; Water | 2003 |
Binding activity of replication protein A to single-stranded DNA containing oxidized pyrimidine base.
Topics: Animals; Base Sequence; Binding Sites; DNA Damage; DNA-Binding Proteins; DNA, Single-Stranded; Oligonucleotides; Oxidation-Reduction; Pentoxyl; Pyrimidines; Replication Protein A; Thymine; Uracil; Xenopus laevis | 2001 |
Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues.
Topics: Cell Line; HIV Reverse Transcriptase; Humans; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thymine; Uracil | 2003 |
Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Conserved Sequence; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Repair; Endodeoxyribonucleases; Escherichia coli; Female; Gene Expression Regulation, Enzymologic; Genetic Complementation Test; Humans; Hypoxanthine; Male; Mice; Molecular Sequence Data; Mutation; Oligonucleotides; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Suppression, Genetic; Thymine; Uracil | 2003 |
Charge driven fragmentation of nucleobases.
Topics: DNA Damage; Gas Chromatography-Mass Spectrometry; Kinetics; Thymine; Uracil | 2003 |
Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes.
Topics: Barbiturates; Cytosine; Enzymes; Thymine; Uracil | 1952 |
beta-amino acid formation by tissue slices incubated with pyrimidines.
Topics: Alanine; Amino Acids; Butyrates; Lipid Metabolism; Liver; Pyrimidines; Thymine; Uracil | 1953 |
Effect of 5-bromouracil on utilization of thymidine by Streptococcus faecalis.
Topics: Bromouracil; Enterococcus faecalis; Streptococcus; Thymidine; Thymine; Uracil | 1954 |
Conversion of uracil to thymine by strains of bacillus subtilis.
Topics: Bacillus; Bacillus subtilis; Thymine; Uracil | 1954 |
Central depressant properties of uracil and related oxypyrimidines.
Topics: Central Nervous System; Central Nervous System Agents; Humans; Hypnotics and Sedatives; Pyrimidines; Thiouracil; Thymine; Uracil | 1955 |
Application of the isotope derivative method to the analysis of pyrimidines.
Topics: Chemistry Techniques, Analytical; Isotopes; Pyrimidines; Thymine; Uracil | 1955 |
Metabolism of intermediate pyrimidine reduction products in vitro.
Topics: Butyrates; In Vitro Techniques; Lipid Metabolism; Liver; Pyrimidines; Thymine; Uracil | 1956 |
Studies on the biosynthesis of bacterial and viral pyrimidines. II. Dihydrouracil and dihydrothymine nucleosides.
Topics: Nucleosides; Nucleotides; Pyrimidines; Thymine; Uracil | 1957 |
[Genetic repercussions of the substitution of thymine by 5-iodouracil in the desoxyribonucleic acid of E. coli 15T-].
Topics: Biochemical Phenomena; DNA; Escherichia coli; Genetic Therapy; Thymine; Uracil | 1957 |
Studies on a relationship of uracil and cytosine nucleosides to biosynthesis of deoxyribonucleic acid thymine.
Topics: Cytosine; DNA; Formates; Nucleosides; Nucleotides; Pyrimidine Nucleosides; Thymine; Uracil | 1958 |
A cytological analysis of the antimetabolite activity of 5-hydroxyuracil in Vicia faba roots.
Topics: Antimetabolites; Cell Nucleus; DNA; DNA Replication; Fabaceae; Mitosis; Plant Roots; Thymidine; Thymine; Uracil; Uridine; Vicia faba | 1958 |
Induction of enzymes for pyrimidine catabolism in Nocardia corallina.
Topics: Nocardia; Oxidoreductases; Pyrimidines; Thymine; Uracil | 1961 |
Inhibition of uracil and thymine degradation by some 5-substituted uracil analogues.
Topics: Biochemical Phenomena; Organic Chemicals; Thymine; Uracil | 1961 |
[Physiological effects of a thymine analog, 5-iodouracil, in E. coli 15 T-].
Topics: Escherichia coli; Organic Chemicals; Thymine; Uracil | 1961 |
Alternative pathways of thymine and uracil metabolism in the liver and hepatoma.
Topics: Carcinoma, Hepatocellular; Humans; Liver; Liver Neoplasms; Thymine; Uracil | 1960 |
Thymine and uracil catabolism in foetal and young rat liver.
Topics: Animals; Fetus; Liver; Rats; Thymine; Uracil | 1960 |
Studies on thymine-5-bromouracil "exchange" in deoxyribonucleic acids of Escherichia coli.
Topics: Bromouracil; DNA; Escherichia coli; Thymine; Uracil | 1959 |
Inhibition of a thymine-deficient mutant of Escherichia coli by 5-substituted uracils.
Topics: Escherichia coli; Nucleosides; Pyrimidines; Thymine; Uracil | 1962 |
[Research on the antimitotic properties of antagonists of natural pyrimidine bases. II. 6-Azauracil, 6-azathymine, 2-thio-5-methylcytosine and 4-methyl-5-bis(beta-chloroethyl)-aminouracil].
Topics: 5-Methylcytosine; Antimitotic Agents; Antineoplastic Agents; Pyrimidines; Thymine; Uracil | 1962 |
[The utilization of thymidine, bromodesoxyuridine and the free pyrimidine bases thymine, bromouracil and iodouracil in desoxyribonucleic acid synthes by ascites tumor cells in vitro].
Topics: Animals; Ascites; Bromouracil; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; In Vitro Techniques; Nucleotides; Pyrimidines; Thymidine; Thymine; Uracil; Uracil Nucleotides | 1962 |
The new occurrence of a new pyrimidine base replacing thymine in a bacteriophage DNA:5-hydroxymethyl uracil.
Topics: Bacteriophages; DNA; DNA, Viral; Pentoxyl; Pyrimidines; Thymine; Uracil | 1962 |
Inability of thymine to replace uracil for growth of Thermobacterium acidophilum (Lactobacillus acidophilus).
Topics: Lactobacillus acidophilus; Thymine; Uracil | 1962 |
Structural specificity of the pyrimidine transport process of the small intestine.
Topics: Barbiturates; Cytosine; Intestine, Small; Intestines; Pyrimidines; Thiouracil; Thymine; Uracil | 1962 |
The action spectra for ultraviolet-light inactivation of systems-containing 5-bromouracil-substituted deoxyribonucleic acid. II. Bacteriophage T4.
Topics: Bacteriophage T4; Bromouracil; Coliphages; DNA; Thymine; Ultraviolet Rays; Uracil | 1963 |
Preparation and chemical and enzymic properties of phosphate esters of 1-(beta-D-glucopyranosyl)uracil and -thymine.
Topics: Esters; Nucleotides; Phosphates; Phosphoric Monoester Hydrolases; Phosphotransferases; Ribonucleases; Thymine; Uracil; Uracil Nucleotides; Venoms | 1962 |
SPLITTING OF URACIL DIMER BY HIGH-ENERGY ELECTRONS.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Electrons; Ion Exchange Resins; Polymers; Radiation Effects; Research; Thymine; Uracil | 1963 |
METABOLIC ACTIVITIES OF MONONUCLEOSIDES ON THE ACTIVATION OF LIVER-PYRUVATE OXIDASE SYSTEM RELATING TO THIAMINE DIPHOSPHATE.
Topics: Chromatography; Guanine; Liver; Nucleosides; Nucleotides; Oxidoreductases; Pharmacology; Portal System; Pyruvate Oxidase; Pyruvates; Rats; Research; Thiamine Pyrophosphate; Thymine; Uracil | 1963 |
INHIBITORY ACTION OF ADENINE, ADENINENUCLEOSIDES AND NUCLEOTIDES ON THE BIOSYNTHESIS OF PORPHYRINS BY RHODOPSEUDOMONASSPHEROIDES.
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Antimetabolites; Chlorophyll; Levulinic Acids; Metabolism; Nucleosides; Nucleotides; Orotic Acid; Pharmacology; Porphyrins; Research; Rhodopseudomonas; Thymine; Uracil | 1963 |
ROLE OF PROTEIN SYNTHESIS IN DNA REPLICATION CYCLE IN BACTERIA.
Topics: Arginine; Autoradiography; Bacteria; Bacterial Proteins; Culture Media; DNA; DNA Replication; DNA, Bacterial; Metabolism; Protein Biosynthesis; Proteins; Research; RNA; RNA, Bacterial; Thymine; Uracil | 1963 |
ACTION OF 5-BROMO-3-SEC-BUTYL-6-METHYLURACIL AS REGARDS REPLACEMENT OF THYMINE IN MOUSE DNA.
Topics: Animals; Bromouracil; Carbon Isotopes; DNA; Liver; Metabolism; Mice; Pyrimidines; Research; Spleen; Thymine; Uracil | 1963 |
BROMINE ANALYSIS IN 5-BROMOURACIL-LABELED DNA BY X-RAY FLUORESCENCE.
Topics: Bromine; Bromouracil; DNA; DNA, Bacterial; Escherichia coli; Fluorescence; Radiation; Research; RNA; RNA, Bacterial; Thymine; Uracil; X-Rays | 1963 |
A THYMINE-REQUIRING MUTANT OF PHAGE T4.
Topics: Bacteriophage T4; Centrifugation; Cesium; Chlorides; Coliphages; Mutation; Nitrites; Research; Thymine; Uracil | 1963 |
[MODIFICATIONS OF INDISPENSABLE FUNCTIONS IN THERMOSENSITIVE ESCHCERICHIA COLI MUTANTS. ON A MUTATION PREVENTING REPLICATION OF THE BACTERIAL CHROMOSOME].
Topics: Chloramphenicol; Chromosomes; Chromosomes, Bacterial; Coliphages; DNA; DNA Replication; DNA, Bacterial; Escherichia coli; Guanidines; Mutation; Nitroso Compounds; Nucleotidases; Pharmacology; Research; Thymine; Trichloroacetic Acid; Uracil | 1963 |
[INHIBITORY ACTION OF NUCLEOSIDES AND ADENINE NUCLEOTIDES ON THE BIOSYNTHESIS OF PORPHYRINS BY RHODOPSEUDOMONAS SPHEROUIDES].
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Antimetabolites; Glycine; Ketoglutaric Acids; Levulinic Acids; Nucleosides; Orotic Acid; Pharmacology; Porphyrins; Research; Rhodopseudomonas; Succinates; Thymidine; Thymine; Uracil | 1963 |
ACCUMULATION OF REPRESSOR FOR ORNITHINE TRANSCARBAMYLASE SYNTHESIS IN ESCHERICHIA COLI MEDIATED BY CHLORAMPHENICOL.
Topics: Alkaline Phosphatase; Antimetabolites; Arginine; Chloramphenicol; Culture Media; Enzyme Inhibitors; Escherichia coli; Galactosidases; Histidine; Leucine; Mutation; Ornithine; Ornithine Carbamoyltransferase; Pharmacology; Phosphotransferases; Proteins; Research; Thymine; Uracil | 1963 |
[SEMI-CONDUCTIBILITY OF DNA (DESOXYRIBONUCLEIC ACID) AND OF PURINE AND PYRIMIDINE BASES OF DNA AND RNA (RIBONUCLEIC ACID)].
Topics: Adenine; Cytosine; DNA; Electrophysiology; Guanine; Purines; Pyrimidines; Research; RNA; Thymine; Uracil | 1963 |
X-RAY DIFFRACTION STUDY OF A DNA WHICH CONTAINS URACIL.
Topics: Bacillus subtilis; Bacteriophages; Chemistry Techniques, Analytical; DNA; DNA, Viral; Research; RNA; RNA, Viral; Thymine; Uracil; X-Ray Diffraction | 1964 |
CONVERSION OF THYMINE TO 5-HYDROXYMETHYLURACIL IN A CELL-FREE SYSTEM.
Topics: Autoradiography; Cell-Free System; Chromatography; Dialysis; Glutathione; Metabolism; NADP; Neurospora; Pentoxyl; Pharmacology; Pyrimidines; Renal Dialysis; Research; Thymine; Uracil | 1964 |
[ON THE INCORPORATION OF BROMOURACIL INTO THE DESOXYRIBONUCLEIC ACID OF TUMOR-BEARING MICE BY ADMINISTRATION OF BROMOURACIL AND DESOXYGUANOSINE].
Topics: Animals; Bromouracil; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Mice; Nucleosides; Research; Sarcoma 37; Thymine; Uracil | 1963 |
A PHAGE INFECTING SAPROSPIRA GRANDIS.
Topics: Adenine; Adenine Nucleotides; Bacteria; Bacterial Proteins; Bacteriophages; Cellulose; Chemistry Techniques, Analytical; Chromatography; Coliphages; Cytosine; Deoxyribonucleases; DNA; DNA, Bacterial; DNA, Viral; Electrons; Guanine; Microscopy; Microscopy, Electron; Research; Ribonucleases; RNA; RNA, Bacterial; RNA, Viral; Thymine; Uracil; Viral Proteins | 1964 |
[ON MOBILITY OF PURINES AND PYRIMIDINE BASES AND THEIR DERIVATIVES DURING ELECTROPHORETIC SEPARATION].
Topics: Adenine; Adenine Nucleotides; Cytosine Nucleotides; Electrophoresis; Guanine; Nucleosides; Nucleotides; Purines; Pyrimidines; Research; Thymidine; Thymine; Uracil | 1964 |
BASIC MECHANISMS IN THE RADIATION CHEMISTRY OF PROTEINS AND THE NUCLEIC ACIDS.
Topics: Alcohol Oxidoreductases; Deoxyribonucleases; DNA; Endopeptidases; Fructose-Bisphosphate Aldolase; Muramidase; Nucleic Acids; Proteins; Radiation Effects; Radiation Injuries; Radiation Injuries, Experimental; Research; Ribonucleases; RNA; Thymine; Uracil | 1964 |
PURE CLONES OF LACTOSE-NEGATIVE MUTANTS OBTAINED IN ESCHERICHIA COLI AFTER TREATMENT WITH 5-BROMOURACIL.
Topics: Bromouracil; Culture Media; Escherichia coli; Lactose; Metabolism; Mutation; Pharmacology; Research; Thymine; Uracil | 1964 |
ENVIRONMENTAL CONDITIONS AFFECTING THE EXPRESSION OF X-RAY-INDUCED LETHALITY IN AN AUXOTROPHIC BACTERIUM.
Topics: Arginine; Bacteria; Bacterial Proteins; Culture Media; DNA; DNA, Bacterial; Escherichia coli; Mutation; Proteins; Radiation Effects; Research; RNA; RNA, Bacterial; Thymine; Uracil; X-Rays | 1964 |
STUDIES ON THE ACID-SOLUBLE NUCLEOTIDE POOL IN THYMINE-REQUIRING MUTANTS OF ESCHERICHIA COLI DURING THYMINE STARVATION. I. ACCUMULATION OF DEOXYADENOSINE TRIPHOSPHATE IN ESCHERICHIA COLI 15 T-A-U-.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Arginine; Chromatography; Colorimetry; Deoxyadenine Nucleotides; Deoxyadenosines; Escherichia coli; Guanine Nucleotides; Metabolism; Mutation; Nucleotides; Perchlorates; Polyphosphates; Research; Ribose; Thymine; Uracil | 1964 |
THE EFFECT OF NATURAL AND UNNNATURAL PYRIMIDINES AND PYRIMIDINE NUCLEOSIDES ON THE PHOSPHOROLYSIS OF 5-IODODEOXYURIDINE BY MOUSE LIVER EXTRACT.
Topics: Animals; Chromatography; Deoxyuridine; Floxuridine; Fluorouracil; Idoxuridine; Iodine Isotopes; Liver; Liver Extracts; Metabolism; Mice; Nucleosides; Pharmacology; Phosphotransferases; Pyrimidine Nucleosides; Pyrimidines; Research; Thymidine; Thymine; Uracil | 1964 |
THE DYE-SENSITIZED PHOTOOXIDATION OF PURINE AND PYRIMIDINE DERIVATIVES.
Topics: Caffeine; Guanine; Guanine Nucleotides; Hydrogen-Ion Concentration; Hypoxanthines; Infrared Rays; Light; Manometry; Methylene Blue; Nucleosides; Oxidation-Reduction; Purines; Research; Theobromine; Theophylline; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uric Acid; Xanthines | 1964 |
THE PHOTO-RESTORATION OF NUCLEIC ACID BIOSYNTHESIS IN THE BACTERIUM ESCHERICHIA COLI.
Topics: DNA; DNA, Bacterial; Escherichia; Escherichia coli; Light; Metabolism; Phenylalanine; Research; RNA; RNA, Bacterial; Spectrophotometry; Thymine; Ultraviolet Rays; Uracil | 1964 |
CHANGES OF THE NUCLEIC ACID CONTENT IN THE RABBIT ORGANS UNDER THE IRRADIATION OF ROENTOGEN RAY.
Topics: Adenine; Adrenal Glands; Antitoxins; Bone Marrow; Cytosine; DNA; Guanine; Liver; Metabolism; Nucleic Acids; Rabbits; Radiation Effects; RNA; Spleen; Thymine; Toxins, Biological; Uracil | 1964 |
THYMINE ANALOGS: THE SYNTHESIS OF 5-DIFLUOROMETHYLURACIL.
Topics: Antineoplastic Agents; Chemistry, Pharmaceutical; Research; Thymine; Uracil | 1963 |
[MECHANISM OF THE MUTAGENIC ACTION OF 5-BROMOURACIL. I. REPLACEMENT OF THYMINE BY 5-BROMOURACIL IN THE DNA OF S. TYPHIMURIUM NO. 70 AND THE MUTAGENIC EFFECT OF THE ANALOG].
Topics: Bromouracil; Chromatography; DNA; DNA, Bacterial; Mutagens; Mutation; Salmonella typhimurium; Thymine; Uracil | 1964 |
FORMATION OF RIBOMONONUCLEOTIDES FROM PURINE AND PYRIMIDINE BASES AND 5'-PHOSPHORIBOSYLPYROPHOSPHATE BY A SALMON MILT EXTRACT.
Topics: Adenine; Adenine Nucleotides; Animals; Carbon Isotopes; Chromatography; Cytosine; Cytosine Nucleotides; Diphosphates; Fishes; Guanine; Guanine Nucleotides; Metabolism; Nucleotides; Orotic Acid; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Research; Salmon; Thymine; Tissue Extracts; Tritium; Uracil; Uracil Nucleotides; Xanthines | 1964 |
THE SYNTHESIS OF MESSENGER RNA WITHOUT PROTEIN SYNTHESIS. I. STUDIES WITH THYMINELESS STRAINS OF ESCHERICHIA COLI.
Topics: Amino Acids; Escherichia coli; Galactosidases; Metabolism; Protein Biosynthesis; Proteins; Research; RNA; RNA, Bacterial; RNA, Messenger; Thymine; Uracil | 1964 |
THE SYNTHESIS OF MESSENGER RNA WITHOUT PROTEIN SYNTHESIS. II. SYNTHESIS OF PHAGE-INDUCED RNA AND SEQUENTIAL ENZYME PRODUCTION.
Topics: Chloramphenicol; Coliphages; Escherichia coli; Histidine; Ligases; Muramidase; Protein Biosynthesis; Research; Ribosomes; RNA; RNA Phages; RNA, Bacterial; RNA, Messenger; Thymine; Transferases; Uracil | 1964 |
SOME BIOCHEMICAL CHANGES ACCOMPANYING PENICILLIN-G RESISTANCE IN STAPHYLOCOCCUS AUREUS.
Topics: Cell Membrane Permeability; Cytosine; DNA; DNA, Bacterial; Mutation; Nitrogen; Penicillin G; Penicillin Resistance; Penicillinase; Proteins; Research; RNA; RNA, Bacterial; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Thymine; Uracil | 1964 |
DARK REPAIR OF ULTRAVIOLET INJURY IN E. COLI DURING DEPRIVATION OF THYMINE.
Topics: Arginine; Carbon Isotopes; Darkness; DNA; DNA, Bacterial; Escherichia coli; Metabolism; Mutation; Research; Thymidine; Thymine; Ultraviolet Rays; Uracil; Wound Healing | 1964 |
QUANTITATIVE E.S.R.-MEASUREMENTS OF RADIATION-INDUCED RADICALS IN NUCLEIC-ACID BASES AND PENTOSES.
Topics: Adenine; Chemistry Techniques, Analytical; Cytosine; Electron Spin Resonance Spectroscopy; Guanine; Inorganic Chemicals; Nucleic Acids; Pentoses; Pyrimidines; Radiation; Radiation Effects; Research; Ribose; Thymine; Uracil; Xanthines | 1964 |
BOUND WATER, METABOLITES AND GENETIC CONTINUITY.
Topics: Amino Acids; Culture Media; DNA; DNA, Bacterial; Escherichia coli; Galactosidases; Genes; Humidity; Lactose; Metabolism; Mutation; Proteins; Radiation Genetics; Research; Thymine; Ultraviolet Rays; Uracil; Water | 1964 |
MACROMOLECULAR SYNTHESES IN THE INITIATION OF BACTERIOPHAGE P1 INDUCTION.
Topics: Bacteriophage P1; Coliphages; DNA; DNA, Viral; Kinetics; Metabolism; Mitomycin; Mitomycins; Research; Ribosomes; RNA; RNA, Viral; Thymine; Uracil | 1964 |
METABOLIC CONTROL OF PENICILLINASE BIOSYNTHESIS IN BACILLUS CEREUS.
Topics: Azaguanine; Bacillus cereus; Cephalosporins; Cytosine; Dactinomycin; Enzyme Inhibitors; Mercury; Penicillanic Acid; Penicillin G; Penicillinase; Penicillins; Pharmacology; Proteins; Research; RNA; RNA, Messenger; Thymine; Uracil | 1964 |
THE INFLUENCE OF HETEROATOMS AND SUBTITUENTS ON THE TAUTOMERIC EQUILIBRIA IN BIOCHEMICAL PURINES AND PYRIMIDINES. I. AZAPURINES AND AZAPYRIMIDINES.
Topics: Adenine; Amines; Cytosine; Guanine; Hypoxanthines; Imines; Kinetics; Nitrogen; Purines; Pyrimidines; Research; Thymine; Uracil; Xanthines | 1964 |
RAPIDLY LABELED RIBONUCLEIC ACIDS OF RHODOPSEUDOMONAS SPHEROIDES UNDER VARYING CONDITIONS OF CATALASE SYNTHESIS.
Topics: Adenine; Catalase; Chemistry Techniques, Analytical; Cytosine; DNA; DNA, Bacterial; Guanine; Metabolism; Research; Rhodobacter sphaeroides; Rhodopseudomonas; RNA; RNA, Bacterial; Spectrophotometry; Thymine; Uracil; Uracil Nucleotides | 1964 |
[SEPARATION OF DNA COMPONENTS ON CELLULOSE LAYERS].
Topics: Adenine; Cellulose; Chromatography; Cytosine; DNA; Guanine; Nucleosides; Nucleotides; Research; Thymine; Uracil | 1964 |
PURINE AND PYRIMIDINES IN SEDIMENTS FROM THE EXPERIMENTAL MOHOLE.
Topics: Adenine; Chemistry Techniques, Analytical; Cytosine; Guanine; Purines; Pyrimidines; Research; Soil; Thymine; Uracil | 1964 |
[ON THE SEMI-CONDUCTIVITY OF PURINE AND PYRIMIDINE BASES OF NUCLEIC ACIDS].
Topics: Adenine; Chemical Phenomena; Chemistry, Physical; Cytosine; Guanine; Nucleic Acids; Purines; Pyrimidines; Research; Thymine; Uracil | 1964 |
PYRIMIDINE INCORPORATION INTO NUCLEIC ACIDS OF CORYNEBACTERIA SPP.
Topics: Corynebacterium; DNA; DNA, Bacterial; Nucleic Acids; Orotic Acid; Proteins; Pyrimidines; Research; RNA; RNA, Bacterial; Thymine; Uracil | 1964 |
3-RIBOSYLPURINES. II. STUDIES ON (3-RIBOSYLXANTHINE) 5'-PHOSPHATE AND ON RIBONUCLEOTIDE DERIVATIVES OF CERTAIN URACIL ANALOGUES.
Topics: Animals; Cattle; Chromatography; Erythrocytes; Glucosyltransferases; Metabolism; Nucleotides; Phosphates; Purines; Pyrimidines; Research; Ribonucleotides; Ribose; Spectrophotometry; Thymine; Uracil; Uric Acid; Xanthines | 1964 |
[MACROMOLECULAR MODIFICATIONS IN A PATHOGENIC BACTERIUM BY MEANS OF ANTIMETABOLITES OF NUCLEIC ACIDS: COMPARATIVE EFFECTS OF 5-FLUOROURACIL AND ACRIDINE ORANGE ON VIRULENCE INDICATORS IN STAPHYLOCOCCUS AUREUS].
Topics: Acridine Orange; Acridines; Antigens; Antimetabolites; DNA; DNA, Bacterial; Fluorescence; Fluorouracil; Immunodiffusion; Microscopy; Microscopy, Fluorescence; Pharmacology; Research; RNA; RNA, Bacterial; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Thymine; Uracil; Virulence | 1964 |
SYNTHETIC PYRIMIDINES AS INHIBITORS OF URACIL AND THYMINE DEGRADATION BY RAT-LIVER SUPERNATANT.
Topics: Catalysis; Liver; Metabolism; NADP; Oxidoreductases; Pharmacology; Pyrimidines; Rats; Research; Thymine; Uracil | 1964 |
A RAPID METHOD FOR THE SEPARATION OF NUCLEIC ACID BASES.
Topics: Adenine; Chromatography; Cytosine; Guanine; Nucleic Acids; Purines; Pyrimidines; Research; Spectrum Analysis; Thymine; Uracil | 1964 |
STUDIES ON THE PHOSPHORYLATION OF THYMIDINE IN REGENERATING RAT LIVER.
Topics: Cytosine; DNA; Fluorides; Liver Diseases; Liver Regeneration; Nucleosides; Nucleotidases; Oxidative Phosphorylation; Phosphorylation; Rats; Research; Thymidine; Thymidine Kinase; Thymine; Uracil | 1964 |
IONIZING RADIATION: EFFECT OF IRRADIATED MEDIUM ON SYNTHETIC PROCESSES.
Topics: beta-Galactosidase; Carbon Isotopes; DNA; DNA, Bacterial; Escherichia coli; Galactosidases; Macromolecular Substances; Metabolism; Proline; Proteins; Radiation Effects; Radiation, Ionizing; Radiometry; Research; Thymine; Uracil; Valine | 1965 |
INTERMOLECULAR FORCES IN ASSOCIATION OF PURINES WITH POLYBENZENOID HYDROCARBONS.
Topics: Adenine; Benzopyrenes; Caffeine; Chemical Phenomena; Chemistry; Cytosine; Guanine; Hypoxanthines; London; Purines; Pyrimidines; Research; Thymine; Uracil; Uric Acid; Xanthines | 1965 |
THE EFFECT OF 5-BROMODEOXYURIDINE ON THE RECOVERY PHENOMENON IN SUB-LETHALLY IRRADIATED CELLS.
Topics: Bromodeoxyuridine; DNA; Nucleosides; Pharmacology; Radiation Injuries; Radiation Injuries, Experimental; Research; Thymine; Tissue Culture Techniques; Uracil | 1964 |
THE INCORPORATION AND DEGRADATION OF PYRIMIDINE DNA PRECURSORS BY HUMAN LEUCOCYTES.
Topics: Autoradiography; Carbon Isotopes; Cytosine Nucleotides; Deoxyuridine; DNA; Humans; Infectious Mononucleosis; Leukemia; Leukemia, Myeloid; Leukocytes; Metabolism; Pyrimidines; Thymidine; Thymine; Tritium; Uracil | 1964 |
INFLUENCE OF PURINE AND PYRIMIDINE COMPOUNDS ON DNA-SYNTHESIS OF ASCITES-TUMOUR CELLS.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Cytosine Nucleotides; DNA; DNA, Neoplasm; Fluorouracil; Metabolism; Neoplasms, Experimental; Nucleotides; Pharmacology; Phosphorus Isotopes; Purines; Pyrimidines; Research; Thymine; Uracil; Uracil Nucleotides | 1964 |
MEMBRANE TRANSPORT OF PURINES AND PYRIMIDINES IN A CESTODE.
Topics: Adenine; Biological Transport; Cell Membrane Permeability; Cestoda; Chromatography; Cytosine; Hypoxanthines; Kinetics; Metabolism; Purines; Pyrimidines; Research; Thymine; Uracil; Xanthines | 1965 |
UPTAKE AND INCORPORATION OF THYMINE, THYMIDINE, URACIL, URIDINE, AND 5-FLUOROURACIL INTO THE NUCLEIC ACIDS OF BACILLUS SUBTILIS.
Topics: Bacillus subtilis; Carbon Isotopes; DNA; DNA, Bacterial; Fluorouracil; Metabolism; Nucleosides; Research; RNA; RNA, Bacterial; Thymidine; Thymine; Tritium; Uracil; Uridine | 1965 |
MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.
Topics: Adenine; Arginine; Bacterial Proteins; Carbon Isotopes; DNA Replication; DNA, Bacterial; Escherichia coli; Nalidixic Acid; Naphthyridines; Pharmacology; Research; RNA; RNA, Bacterial; Thymidine; Thymine; Uracil | 1965 |
RADIOLYSIS OF THYMINE IN AQUEOUS SOLUTIONS: CHANGE IN SITE OF ATTACK WITH CHANGE IN PH.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Hydrogen-Ion Concentration; Radiation Effects; Radiometry; Research; Solutions; Thymine; Uracil; Urea | 1965 |
THIOURACIL-PYRIMIDINE RELATIONSHIPS IN THYROID AND OTHER TISSUES.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Cattle; Liver; Metabolism; Organ Size; Orotic Acid; Pharmacology; Pyrimidines; Rats; Research; RNA; Thiouracil; Thymine; Thymus Gland; Thyroid Gland; Uracil; Uracil Nucleotides | 1965 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
[ON THE EFFECT OF 5-BROMOURACIL AND 5-FLUOROURACIL ON THE VIRUS INDUCTION OF A LYSOGENIC THYMINE-LESS MUTANT OF E. COLI BY MEANS OF ULTRAVIOLET RAYS].
Topics: Bromouracil; Coliphages; DNA; Escherichia coli; Fluorouracil; Lysogeny; Research; Thymine; Ultraviolet Rays; Uracil; Virus Activation | 1964 |
EFFECT OF AZASERINE ON THE INCORPORATION OF 14-C-LABELED PURINES AND PYRIMIDINES INTO ACID-SOLUBLE AND NUCLEIC ACID FRACTIONS OF TRYPANOSOMA EQUIPERDUM.
Topics: Adenine; Amino Acids; Azaserine; Cytosine; Cytosine Nucleotides; DNA; Glutamine; Guanine; Hypoxanthines; Leucine; Metabolism; Nucleic Acids; Orotic Acid; Pharmacology; Purines; Pyrimidines; Research; RNA; Thymine; Trypanosoma; Tryptophan; Tyrosine; Uracil; Uracil Nucleotides | 1965 |
EVIDENCE OF LYSOGENY IN DERIVATIVES OF ESCHERICHIA COLI.
Topics: Bacteriolysis; Carbon Isotopes; Coliphages; DNA, Bacterial; Electrons; Escherichia coli; Lysogeny; Metabolism; Microscopy; Microscopy, Electron; Mitomycin; Mitomycins; Nucleosides; Pharmacology; Radiation Effects; Radiometry; Research; RNA; RNA, Bacterial; Thymine; Ultraviolet Rays; Uracil; Uridine | 1965 |
EFFECT OF CERTAIN PURINE AND PYRIMIDINE ANALOGUES ON GROWTH, NUCLEIC ACID SYNTHESIS AND ULTRAVIOLET-INDUCED LYSIS IN VIBRIO CHOLERAE.
Topics: Azaguanine; Bacteriolysis; DNA; DNA, Bacterial; Metabolism; Pharmacology; Purines; Pyrimidines; Research; RNA; RNA, Bacterial; Thymine; Triazines; Ultraviolet Rays; Uracil; Vibrio; Vibrio cholerae | 1965 |
A NOVEL EFFECT OF ACTINOMYCIN D IN PREVENTING BACTERIOPHAGE T4 MATURATION IN ESCHERICHIA COLI.
Topics: Bacteriophage T4; Coliphages; Dactinomycin; DNA; DNA, Viral; Escherichia coli; Leucine; Pharmacology; Proteins; Research; RNA; RNA, Viral; Thymine; Uracil | 1965 |
A METHOD FOR SELECTIVE ENRICHMENT OF MUTANTS BASED ON THE HIGH UV SENSITIVITY OF DNA CONTAINING 5-BROMOURACIL.
Topics: Bacteriological Techniques; Bromouracil; DNA; DNA, Bacterial; Escherichia coli; Metabolism; Molecular Biology; Mutation; Radiation Effects; Research; Thymine; Ultraviolet Rays; Uracil | 1965 |
FREE-RADICAL FORMATION IN IRRADIATED DEOXYRIBONUCLEIC ACID.
Topics: Bromine; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Cold Temperature; DNA; Electron Spin Resonance Spectroscopy; Nucleosides; Radiation Effects; RNA; Spectrum Analysis; Thymine; Uracil; Uracil Nucleotides; Uridine | 1965 |
Some physiological and genetic properties of a strain of Escherichia coli requiring thymine, arginine and uracil.
Topics: Arginine; Biochemical Phenomena; Escherichia coli; Thymine; Uracil | 1959 |
Active transport of some pyrimidines across the rat intestinal epithelium.
Topics: Animals; Biological Transport, Active; Intestinal Mucosa; Intestine, Small; Intestines; Pyrimidines; Rats; Thymine; Uracil | 1960 |
Permeability of Ehrlich cells to uracil, thymine and fluorouracil.
Topics: Fluorouracil; Humans; Neoplasms; Permeability; Thymine; Uracil | 1962 |
Utilization of pyrimidines and pyrimidine deoxynucleosides by Thermobacterium acidophilum (Lactobacillus acidophilus).
Topics: Lactobacillus; Lactobacillus acidophilus; Nucleosides; Nucleotides; Pentosyltransferases; Pyrimidines; Sweden; Thymidine; Thymine; Uracil | 1961 |
Some effects of 5-bromouracil on a thymine-requiring mutant of Escherichia coli.
Topics: Biochemical Phenomena; Bromouracil; Escherichia coli; Nucleosides; Nucleotides; Thymine; Uracil | 1962 |
Chemical effect of ionizing radiation on cytosine.
Topics: Cytosine; Pyrimidines; Radiation Effects; Radiation, Ionizing; Thymine; Uracil | 1962 |
Effect of 6-azathymine, an analog of thymine, on the urinary excretion of uracil.
Topics: Nucleosides; Nucleotides; Organic Chemicals; Thymine; Uracil | 1962 |
On the aromatic character of the heterocyclic bases of DNA and RNA.
Topics: Adenine; Base Pairing; Cytosine; DNA; Guanine; Hydrogen Bonding; Mathematical Computing; Nucleic Acid Conformation; Quantum Theory; RNA; Stereoisomerism; Thymine; Uracil | 2003 |
Conformational restriction of nucleosides by spirocyclic annulation at C4' including synthesis of the complementary dideoxy and didehydrodideoxy analogues.
Topics: Alkanes; Dideoxynucleosides; Hydroxylation; Models, Chemical; Molecular Conformation; Nucleosides; Spiro Compounds; Stereoisomerism; Sulfenic Acids; Thymine; Tin Compounds; Uracil | 2003 |
New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?
Topics: Aminoisobutyric Acids; beta-Alanine; Brain Diseases, Metabolic, Inborn; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Homeostasis; Humans; Inactivation, Metabolic; Neurotransmitter Agents; Purine-Pyrimidine Metabolism, Inborn Errors; Stereoisomerism; Thymine; Uracil; Valine | 2004 |
Thymidine kinase and thymidine phosphorylase level as the main predictive parameter for sensitivity to TAS-102 in a mouse model.
Topics: Animals; Antineoplastic Agents; Cell Division; Drug Combinations; Head and Neck Neoplasms; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Pancreatic Neoplasms; Pyrrolidines; Stomach Neoplasms; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Thymine; Transplantation, Heterologous; Trifluridine; Uracil | 2004 |
Antagonists of nucleic acid derivatives. II. Reversal studies with substances structurally related to thymine.
Topics: Folic Acid; Lacticaseibacillus casei; Nucleic Acids; Thymine; Uracil | 1950 |
TDDFT investigation on nucleic acid bases: comparison with experiments and standard approach.
Topics: Adenine; Cytosine; Guanine; Models, Molecular; Nucleic Acids; Thermodynamics; Thymine; Uracil | 2004 |
Nucleotide excision repair of 5-formyluracil in vitro is enhanced by the presence of mismatched bases.
Topics: Base Pair Mismatch; Cell-Free System; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; DNA, Circular; Electrophoretic Mobility Shift Assay; Humans; Protein Binding; Thymine; Uracil; Xeroderma Pigmentosum | 2004 |
A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells.
Topics: Animals; Antimetabolites; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; Coloring Agents; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Globins; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Chemical; Neoplasm Metastasis; Neoplasm Transplantation; Polymerase Chain Reaction; Pyrrolidines; Sensitivity and Specificity; Tetrazolium Salts; Thiazoles; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil | 2004 |
Chemical synthesis and translesion replication of a cis-syn cyclobutane thymine-uracil dimer.
Topics: DNA Replication; DNA-Directed DNA Polymerase; Humans; Oligodeoxyribonucleotides; Pyrimidine Dimers; Thymine; Uracil | 2004 |
A molecular dissection of the interaction between the transcription factor Gata-1 zinc finger and DNA.
Topics: Amino Acid Sequence; Animals; Apoptosis; Binding Sites; Chickens; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Erythroid-Specific DNA-Binding Factors; Hydrogen Bonding; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Sequence Data; Oligonucleotides; Protein Binding; Thermodynamics; Thymine; Transcription Factors; Ultraviolet Rays; Uracil; Zinc Fingers | 2004 |
Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state.
Topics: Calibration; Chromatography, High Pressure Liquid; Cobalt Radioisotopes; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Gamma Rays; Models, Chemical; Nitrogen; Oxygen; Pentoxyl; Photons; Spectrophotometry; Synchrotrons; Thymine; Time Factors; Uracil; X-Rays | 2004 |
Ion desorption from DNA components irradiated with 0.5 keV ultrasoft X-ray photons.
Topics: Carbohydrates; Deoxyribose; DNA; DNA Damage; Electrons; Hydrogen; Ions; Mass Spectrometry; Models, Chemical; Models, Statistical; Oxygen; Photons; Thymine; Uracil; X-Rays | 2004 |
Exciplex formation between pyrene and guanine in highly polar solvents.
Topics: Acetonitriles; Adenine; Cytosine; Dimethylformamide; Guanine; Hydrocarbons; Methane; Pyrenes; Solvents; Spectrometry, Fluorescence; Thymine; Uracil; Water | 2004 |
Highly efficient photochemical 2'-deoxyribonolactone formation at the diagonal loop of a 5-iodouracil-containing antiparallel G-quartet.
Topics: Chromatography, High Pressure Liquid; Indicators and Reagents; Light; Models, Molecular; Molecular Conformation; Oligonucleotides; Photochemistry; Potassium; Sodium; Sugar Acids; Thymine; Ultraviolet Rays; Uracil | 2004 |
Low temperature Fourier transform infrared spectra and hydrogen bonding in polycrystalline uracil and thymine.
Topics: Cold Temperature; Hydrogen Bonding; Spectroscopy, Fourier Transform Infrared; Thymine; Uracil | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Combinations; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pyrrolidines; Rats; Rats, Nude; Stomach Neoplasms; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2004 |
Head imaging abnormalities in dihydropyrimidine dehydrogenase deficiency.
Topics: Brain; Dihydropyrimidine Dehydrogenase Deficiency; Fatal Outcome; Female; Humans; Infant; Magnetic Resonance Imaging; Thymine; Uracil | 2004 |
Studies on the relationships of vitamin B12, folic acid, thymine, uracil and methyl group donors in persons with pernicious anemia and related megaloblastic anemias.
Topics: Anemia; Anemia, Megaloblastic; Anemia, Pernicious; Folic Acid; Hematinics; Thymine; Tissue Donors; Uracil; Vitamin B 12 | 1950 |
X-ray diffraction studies of cytosine, uracil and thymine.
Topics: Cytosine; Pyrimidines; Thymine; Uracil; X-Ray Diffraction | 1960 |
Pharmacokinetic modeling of species-dependent enhanced bioavailability of trifluorothymidine by thymidine phosphorylase inhibitor.
Topics: Administration, Oral; Animals; Biological Availability; Computer Simulation; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Macaca fascicularis; Male; Models, Biological; Pyrrolidines; Rats; Rats, Sprague-Dawley; Species Specificity; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil | 2004 |
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.
Topics: Cloning, Molecular; Deoxyribonuclease (Pyrimidine Dimer); DNA Glycosylases; DNA Repair; DNA, Complementary; Escherichia coli; Humans; Hydrogen Peroxide; Mutation; Oligonucleotides; Pentoxyl; Thymine; Uracil | 2005 |
Hydrogen bonds of RNA are stronger than those of DNA, but NMR monitors only presence of methyl substituent in uracil/thymine.
Topics: Adenine; Base Pairing; DNA; Hydrogen Bonding; Nuclear Magnetic Resonance, Biomolecular; RNA; Thermodynamics; Thymine; Uracil | 2004 |
Interaction of sodium and potassium ions with sandwiched cytosine-, guanine-, thymine-, and uracil-base tetrads.
Topics: Algorithms; Base Pairing; Cytosine; Guanine; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Potassium; Sodium; Thermodynamics; Thymine; Uracil | 2005 |
The stabilizing contribution of thymine in duplexes of (dA)24 with (dU)24, (dT)24, (dU12-dT12), (dU-dT)12, (dU2-dT2)6, or (dU3-dT3)4: nearest neighbor and next-nearest neighbor effects.
Topics: Adenine; Base Composition; Circular Dichroism; Nucleic Acid Conformation; Poly A; Poly T; Poly U; Polydeoxyribonucleotides; Salts; Temperature; Thermodynamics; Thymine; Uracil | 2005 |
Convenient synthesis of nucleoside and isonucleoside analogues.
Topics: Catalysis; Cytosine; Indicators and Reagents; Molecular Structure; Nucleosides; Thymine; Uracil | 2005 |
Modulation of base selectivity for a base-discriminating fluorescent nucleobase by addition of mercury ion.
Topics: Base Pairing; Fluorescent Dyes; Mercury; Oligonucleotide Probes; Spectrometry, Fluorescence; Structure-Activity Relationship; Thymine; Uracil | 2005 |
Dihydropyrimidine dehydrogenase deficiency presenting at birth.
Topics: Age of Onset; Antimetabolites; Binding Sites; Digestive System Abnormalities; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Genes, Recessive; Heterozygote; Homozygote; Humans; Infant, Newborn; Muscular Diseases; Mutation; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 2005 |
Atropisomeric property of 1-(2,6-difluorobenzyl)-3-[(2R)-amino-2-phenethyl]-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil.
Topics: Chromatography, High Pressure Liquid; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Receptors, LHRH; Stereoisomerism; Thymine; Uracil | 2005 |
Bond- and site-selective loss of H- from pyrimidine bases.
Topics: DNA; DNA Damage; Electrons; Hydrogen; Methylation; Plasmids; Thermodynamics; Thymine; Uracil | 2005 |
Condensation of nucleobases at mercury/aqueous solution interface--a structural perspective using hydrogen bonding considerations.
Topics: Adenine; Adenosine; Adsorption; Cytosine; Electrodes; Electrolytes; Guanine; Hydrogen Bonding; Mercury; Potassium; Purines; Pyrimidines; Sodium; Solutions; Thermodynamics; Thiouracil; Thymine; Uracil; Water | 2002 |
Light-induced surface wettability of a tethered DNA base.
Topics: Dimerization; DNA; Light; Thymine; Ultraviolet Rays; Uracil; Wettability | 2005 |
Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages.
Topics: Antioxidants; Aorta; Atherosclerosis; Chlorides; Chromatography, High Pressure Liquid; DNA; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Granulocyte-Macrophage Colony-Stimulating Factor; Heme; Humans; Hydrogen-Ion Concentration; Macrophages; Models, Chemical; Monocytes; Mutagenesis; Mutation; Nicotine; Peroxidase; Phenotype; Temperature; Thymine; Time Factors; Uracil | 2006 |
Characterization of novel Na+-dependent nucleobase transport systems at the blood-testis barrier.
Topics: Adenine; Animals; Biological Transport; Blood-Testis Barrier; Cytosine; Guanine; Hypoxanthine; Kinetics; Male; Meglumine; Nucleobase Transport Proteins; Nucleoside Transport Proteins; Purine Nucleosides; Pyrimidine Nucleosides; Rats; Rats, Inbred Strains; Sertoli Cells; Sodium; Thioinosine; Thymine; Uracil; Uridine | 2006 |
Singlet excited-state behavior of uracil and thymine in aqueous solution: a combined experimental and computational study of 11 uracil derivatives.
Topics: Models, Molecular; Solutions; Spectrometry, Fluorescence; Thermodynamics; Thymine; Uracil; Water | 2006 |
Beta-ureidopropionase deficiency presenting with febrile status epilepticus.
Topics: Amidohydrolases; Atrophy; Central Nervous System Diseases; Diagnosis, Differential; Fever; Hematoma, Subdural; Humans; Infant; Magnetic Resonance Imaging; Male; Mutation; Psychomotor Disorders; Purine-Pyrimidine Metabolism, Inborn Errors; Seizures, Febrile; Status Epilepticus; Thymine; Uracil | 2006 |
Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry.
Topics: Adolescent; beta-Alanine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Epilepsy; Exons; Female; Genotype; Humans; Infant; Infant, Newborn; Ions; Male; Mass Spectrometry; Models, Statistical; Mutation; Normal Distribution; Ornithine Carbamoyltransferase Deficiency Disease; Pyrimidines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Thymine; Uracil | 2005 |
Homopairing possibilities of the DNA base thymine and the RNA base uracil: an ab initio density functional theory study.
Topics: Base Pairing; Binding Sites; DNA; Models, Molecular; RNA; Thermodynamics; Thymine; Uracil | 2006 |
Excited-state structural dynamics of cytosine from resonance Raman spectroscopy.
Topics: Algorithms; Cytosine; DNA Damage; Models, Chemical; Photochemistry; Spectrum Analysis, Raman; Thymine; Ultraviolet Rays; Uracil | 2006 |
The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Binding Sites; Crystallization; Crystallography, X-Ray; Dictyostelium; Dimerization; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Folding; Saccharomyces; Substrate Specificity; Thymine; Uracil | 2006 |
Vibrational Feshbach resonances in uracil and thymine.
Topics: Base Composition; Chemistry, Physical; Hydrogen; Hydrogen Bonding; Ions; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Nucleic Acid Conformation; Quantum Theory; Thymine; Uracil; Vibration | 2006 |
Ab initio base-pairing energies of uracil and 5-hydroxyuracil with standard DNA bases at the BSSE-free DFT and MP2 theory levels.
Topics: Adenine; Base Pairing; Cytosine; DNA; Guanine; Models, Molecular; Thymine; Uracil | 2006 |
The influence of microhydration on the ionization energy thresholds of uracil and thymine.
Topics: Ions; Thymine; Uracil; Water | 2005 |
Probing the Watson-Crick, wobble, and sugar-edge hydrogen bond sites of uracil and thymine.
Topics: Binding Sites; Deoxyribose; Dimerization; Hydrogen Bonding; Magnetics; Molecular Structure; Spectrum Analysis; Thymine; Ultraviolet Rays; Uracil | 2005 |
Recognition of oxidized thymine base on the single-stranded DNA by replication protein A.
Topics: Animals; Base Sequence; Binding Sites; DNA, Single-Stranded; Oxidation-Reduction; Replication Protein A; Staining and Labeling; Thymine; Uracil; Xenopus laevis; Xenopus Proteins | 2006 |
American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA.
Topics: Clinical Trials as Topic; Cytarabine; Drug Combinations; Gossypol; Humans; Leukemia; Mastocytosis, Systemic; Molecular Structure; Pyrimidines; Pyrrolidines; Thionucleotides; Thymine; Trifluridine; Uracil | 2006 |
Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism.
Topics: Binding, Competitive; Humans; Kinetics; Ligands; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, LHRH; Thymine; Tritium; Uracil | 2006 |
Michael addition of pyrimidine with disaccharide acrylates catalyzed in organic medium with lipase M from Mucor javanicus.
Topics: Acrylates; Disaccharides; Fluorouracil; Lipase; Mucor; Thymine; Uracil | 2006 |
Ab initio determination of the ionization potentials of DNA and RNA nucleobases.
Topics: Adenine; Base Composition; Biophysics; Calibration; Chemistry, Physical; Cytosine; DNA; Guanine; Ions; Photochemistry; Quantum Theory; RNA; Software; Thymine; Uracil | 2006 |
Selective product amplification of thymine photodimer by recognition-directed supramolecular assistance.
Topics: Catalysis; Crystallography, X-Ray; Dimerization; Hydrogen Bonding; Kinetics; Light; Magnetic Resonance Spectroscopy; Thymine; Uracil | 2006 |
Ion-induced biomolecular radiation damage: from isolated nucleobases to nucleobase clusters.
Topics: Adenine; Base Composition; Biophysics; Chemistry, Physical; DNA; Electrons; Hydrogen Bonding; Ions; Mass Spectrometry; Molecular Conformation; Purines; Pyrimidines; Spectrophotometry; Thymine; Uracil | 2006 |
[Chemical constituents from the south China sea gorgonian coral Subergorgia reticulata].
Topics: Animals; Anthozoa; Cholesterol; Glyceryl Ethers; Guanine; Magnetic Resonance Spectroscopy; Thymine; Uracil | 2006 |
Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma.
Topics: Adenine; Aged; Alleles; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; DNA, Complementary; Exons; Fatal Outcome; Female; Fluorouracil; Gene Frequency; Humans; Introns; Mutation; Pedigree; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Thymine; Uracil | 2007 |
A neonate with recurrent vomiting and generalized hypotonia diagnosed with a deficiency of dihydropyrimidine dehydrogenase.
Topics: Developmental Disabilities; Dihydrouracil Dehydrogenase (NADP); Female; Homozygote; Humans; Infant; Leukocytes, Mononuclear; Muscle Hypotonia; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil; Vomiting | 2006 |
RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors.
Topics: DNA Damage; DNA Helicases; DNA Repair; DNA Repair Enzymes; Elongin; Guanine; HeLa Cells; Humans; Oxidative Stress; Poly-ADP-Ribose Binding Proteins; RNA Polymerase II; Thymine; Transcription Factors; Transcription Factors, TFII; Transcription, Genetic; Transcriptional Elongation Factors; Uracil | 2006 |
On the unusual stability of valence anions of thymine based on very rare tautomers: A computational study.
Topics: Anions; Computer Simulation; Electrons; Methylation; Molecular Structure; Thymine; Uracil; Water | 2006 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Pyrrolidines; Sensitivity and Specificity; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Tumor Cells, Cultured; Uracil; Xenograft Model Antitumor Assays | 2007 |
Structure and cytotoxicity of a new lanostane-type triterpene glycoside from the sea cucumber Holothuria hilla.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cholesterol; Drug Screening Assays, Antitumor; Glycosides; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Sea Cucumbers; Spectrometry, Mass, Electrospray Ionization; Thymine; Triterpenes; Uracil | 2006 |
Janus-AT bases: synthesis, self-assembly, and solid state structures.
Topics: Adenine; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Molecular Structure; Thymine; Uracil | 2007 |
Investigation of proton transport tautomerism in clusters of protonated nucleic acid bases (cytosine, uracil, thymine, and adenine) and ammonia by high-pressure mass spectrometry and ab initio calculations.
Topics: Adenine; Algorithms; Ammonia; Binding Sites; Cytosine; DNA; Isomerism; Protons; RNA; Spectrometry, Mass, Electrospray Ionization; Thermodynamics; Thymine; Uracil | 2007 |
Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides.
Topics: Catalysis; Cytosine; Enzymes; Hydrolysis; Models, Chemical; Pyrimidine Nucleosides; Pyrimidine Nucleotides; Pyrimidinones; Thermodynamics; Thymine; Uracil | 2007 |
Microhydration of cytosine and its radical anion: cytosine.(H2O)n (n=1-5).
Topics: Anions; Cytosine; Free Radicals; Hydrogen Bonding; Models, Chemical; Thymine; Uracil; Water | 2007 |
An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents.
Topics: Antineoplastic Agents; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Intestines; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Rotavirus; Stereoisomerism; Structure-Activity Relationship; Thymine; Uracil; Xylose; Zidovudine | 2007 |
Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Brain; Child, Preschool; Crystallography, X-Ray; Dictyostelium; Enzyme Stability; Escherichia coli; Humans; Language Development Disorders; Magnetic Resonance Imaging; Male; Models, Molecular; Molecular Sequence Data; Mutation, Missense; Protein Conformation; Saccharomyces; Siblings; Thymine; Uracil | 2007 |
Infrared laser spectroscopy of uracil and thymine in helium nanodroplets: vibrational transition moment angle study.
Topics: Helium; Molecular Structure; Nanostructures; Spectrophotometry, Infrared; Thymine; Uracil; Vibration | 2007 |
Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MS.
Topics: Adenine; Chromatography, High Pressure Liquid; Fruiting Bodies, Fungal; Ganoderma; Guanine; Hypoxanthine; Mass Spectrometry; Molecular Structure; Nucleosides; Plant Extracts; Reference Standards; Reproducibility of Results; Species Specificity; Technology, Pharmaceutical; Thymine; Uracil | 2007 |
Quantum-chemical investigation of the structures and electronic spectra of the nucleic acid bases at the coupled cluster CC2 level.
Topics: Adenine; Algorithms; Carbon; Cytosine; Electrons; Guanine; Hydrogen; Nitrogen; Nucleic Acids; Quantum Theory; Spectrophotometry; Thermodynamics; Thymine; Uracil | 2007 |
Ab initio base-pairing energies of an oxidized thymine product, 5-formyluracil, with standard DNA bases at the BSSE-free DFT and MP2 theory levels.
Topics: Base Pairing; Calibration; DNA; Hydrogen Bonding; Models, Chemical; Models, Theoretical; Mutagens; Nucleic Acid Conformation; Oxygen; Software; Thermodynamics; Thymidine; Thymine; Uracil | 2007 |
Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.
Topics: Base Sequence; Binding Sites; Chromatography, High Pressure Liquid; CpG Islands; DNA; Escherichia coli; Glycosides; Humans; Kinetics; Models, Chemical; Molecular Sequence Data; Sister Chromatid Exchange; Thymine; Thymine DNA Glycosylase; Uracil | 2007 |
CH/pi interactions in DNA and proteins. A theoretical study.
Topics: Amino Acids; Benzene; Carbon; Computer Simulation; DNA; Hydrogen; Methane; Models, Chemical; Models, Molecular; Molecular Conformation; Proteins; Surface Properties; Thymine; Uracil | 2007 |
[Studies on chemical constitutes of Acantophora spicifera].
Topics: Chromatography; Chromatography, High Pressure Liquid; Rhodophyta; Sesquiterpenes; Styrenes; Thymine; Uracil | 2007 |
Ab initio molecular dynamics and time-resolved photoelectron spectroscopy of electronically excited uracil and thymine.
Topics: Algorithms; Electrons; Photochemistry; Quantum Theory; Spectrum Analysis; Thymine; Time Factors; Uracil | 2007 |
Enzymatic capture of an extrahelical thymine in the search for uracil in DNA.
Topics: Base Pairing; Binding Sites; DNA; DNA Damage; DNA Repair; Escherichia coli; Humans; Models, Molecular; Mutant Proteins; Nucleic Acid Conformation; Protein Conformation; Protons; Pyrimidines; Substrate Specificity; Thymine; Uracil; Uracil-DNA Glycosidase | 2007 |
Strand-biased spreading of mutations during somatic hypermutation.
Topics: Adenine; Animals; B-Lymphocytes; Base Sequence; Cytidine Deaminase; Cytosine; Deamination; DNA Mismatch Repair; Genes, Immunoglobulin; Immunoglobulin kappa-Chains; Immunoglobulin Variable Region; Mice; Mice, Transgenic; Molecular Sequence Data; Somatic Hypermutation, Immunoglobulin; Thymine; Transgenes; Uracil | 2007 |
Near Infrared Absorption Spectra of Uracil, 5-Chlorouracil, and Thymine.
Topics: Anemia; Humans; Thiourea; Thymine; Uracil | 1949 |
Microwave-promoted facile and efficient preparation of N-(alkoxycarbonylmethyl) nucleobases--building blocks for peptide nucleic acids.
Topics: Alkylation; Cytosine; Dimethylformamide; Microwaves; Peptide Nucleic Acids; Purines; Thymine; Time Factors; Uracil | 2007 |
Infrared spectra of protonated uracil, thymine and cytosine.
Topics: Cytosine; Models, Molecular; Protons; Spectrophotometry, Infrared; Thymine; Uracil | 2007 |
Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements.
Topics: Amidohydrolases; Amino Acid Substitution; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; Dimerization; Metalloproteases; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation, Missense; Saccharomyces; Thymine; Uracil | 2007 |
[Studies on chemical constituents of marine bryozoan Bugula neritina L].
Topics: Animals; Bryozoa; Cholestenones; Cholesterol; Cholesterol Esters; Ergosterol; Magnetic Resonance Spectroscopy; Mass Spectrometry; Seawater; Thymine; Uracil | 2007 |
RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimidines.
Topics: Allantoin; Aptamers, Nucleotide; Base Sequence; Binding Sites; Blotting, Northern; Deoxyribonuclease I; DNA Footprinting; Electrophoretic Mobility Shift Assay; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Glutamic Acid; Models, Biological; Mutation; Promoter Regions, Genetic; Protein Binding; Pyrimidines; SELEX Aptamer Technique; Thymine; Transcription Factors; Uracil | 2007 |
Photoelectron spectroscopy of adiabatically bound valence anions of rare tautomers of the nucleic acid bases.
Topics: Adenine; Anions; Base Composition; Chemistry, Physical; Cytosine; DNA; Electrons; Guanine; Ions; Light; Models, Chemical; Molecular Conformation; Nucleic Acid Conformation; Nucleic Acids; RNA; Spectrophotometry; Thymine; Uracil | 2007 |
Photodissociation of uracil.
Topics: Energy Transfer; Heterocyclic Compounds; Kinetics; Mass Spectrometry; Photochemistry; Photolysis; Thermodynamics; Thymine; Uracil | 2007 |
Chemotaxis of Escherichia coli to pyrimidines: a new role for the signal transducer tap.
Topics: Chemotaxis; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Pyrimidines; Receptors, Cell Surface; Signal Transduction; Thymine; Uracil | 2008 |
Interactions of nucleobases with alkali earth metal cations--electrospray ionization mass spectrometric study.
Topics: Cations; Cytosine; Metals, Alkaline Earth; Nucleotides; Pyridines; Pyrimidines; Spectrometry, Mass, Electrospray Ionization; Thymine; Uracil | 2007 |
Ferrocene-linked thymine/uracil conjugates: base pairing directed self-assembly and supramolecular packing.
Topics: Base Pairing; Crystallography, X-Ray; Ferrous Compounds; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metallocenes; Molecular Structure; Spectrophotometry, Infrared; Thymine; Uracil | 2008 |
Probing noncovalent interactions in biomolecular crystals with terahertz spectroscopy.
Topics: Computer Simulation; Crystallization; Hydrogen Bonding; Models, Chemical; Spectroscopy, Fourier Transform Infrared; Thymine; Uracil; Vibration | 2008 |
The thuggacins, novel antibacterial macrolides from Sorangium cellulosum acting against selected Gram-positive bacteria.
Topics: Anti-Bacterial Agents; Antitubercular Agents; Bacterial Proteins; Cytochromes; Gram-Positive Bacteria; Macrolides; Metabolic Networks and Pathways; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium; Myxococcales; NAD; Oxygen; Thymine; Uracil | 2007 |
Thin-film properties of DNA and RNA bases: a combined experimental and theoretical study.
Topics: Cytosine; DNA; Models, Molecular; Molecular Structure; Nanostructures; RNA; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Thymine; Uracil; X-Rays | 2008 |
Oxidative amination of cuprated pyrimidine and purine derivatives.
Topics: Adenine; Amination; Copper; Oxidation-Reduction; Purines; Pyrimidines; Thymine; Uracil | 2008 |
The electron affinities of deprotonated adenine, guanine, cytosine, uracil, and thymine.
Topics: Adenine; Cytosine; Electrons; Gas Chromatography-Mass Spectrometry; Gases; Guanine; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Photochemistry; Protons; Purines; Pyrimidines; Thermodynamics; Thymine; Uracil | 2008 |
Electronic and vibrational spectroscopy of 1-methylthymine and its water clusters: the dark state survives hydration.
Topics: Algorithms; Electrons; Models, Chemical; Phase Transition; Photochemistry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spectrum Analysis; Thymine; Uracil; Vibration; Water | 2008 |
[Chemical constituents from sea cucumber Holothuria nobilis].
Topics: Animals; Cholesterol; Holothuria; Magnetic Resonance Spectroscopy; Molecular Structure; Saponins; Thymine; Uracil | 2008 |
Blood-brain barrier efflux transport of pyrimidine nucleosides and nucleobases in the rat.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Dihydrouracil Dehydrogenase (NAD+); Female; Liver; Male; Microvessels; Rats; Rats, Wistar; Thymidine; Thymine; Tissue Distribution; Uracil; Uridine | 2009 |
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; DNA Repair; DNA, Single-Stranded; Humans; Methylation; Mice; Mixed Function Oxygenases; Oxidation-Reduction; Oxo-Acid-Lyases; Proteins; Recombinant Proteins; RNA; Substrate Specificity; Thymine; Uracil | 2008 |
Stereoselective formation of a cyclobutane pyrimidine dimer by using N4-acetyl protection of the cytosine base.
Topics: Cyclobutanes; Cytosine; Deoxycytidine; Pyrimidine Dimers; Stereoisomerism; Thymine; Ultraviolet Rays; Uracil | 2008 |
Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases.
Topics: Amino Acid Sequence; Animals; Base Pairing; Catalytic Domain; DNA; Evolution, Molecular; Humans; Isoenzymes; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Protein Conformation; Pyrophosphatases; Sequence Alignment; Sequence Homology, Amino Acid; Thymine; Uracil | 2009 |
Microbiological determination of cytosine, uracil and thymine.
Topics: Cytosine; Thymine; Uracil | 1948 |
Electronic splitting in the excited states of DNA base homodimers and -trimers: an evaluation of short-range and Coulombic interactions.
Topics: Adenine; Cytosine; Dimerization; DNA; Electrons; Models, Chemical; Nucleic Acid Conformation; Quantum Theory; Static Electricity; Thymine; Uracil | 2008 |
Interactions of the "piano-stool" [ruthenium(II) (eta6-arene)(en)CL]+ complexes with water and nucleobases; ab initio and DFT study.
Topics: Adenine; Antineoplastic Agents; Binding Sites; Cytosine; Ethylenediamines; Guanine; Models, Molecular; Molecular Structure; Purines; Pyrimidinones; Quantum Theory; Ruthenium; Thermodynamics; Thymine; Uracil; Water | 2009 |
Structures of hydrated Li+-thymine and Li+-uracil complexes by IRMPD spectroscopy in the N-H/O-H stretching region.
Topics: Hydrogen Bonding; Lithium; Molecular Structure; Spectrophotometry, Infrared; Thermodynamics; Thymine; Uracil; Water | 2009 |
Energetic and hydration contributions of the removal of methyl groups from thymine to form uracil in G-quadruplexes.
Topics: Calorimetry; G-Quadruplexes; Methylation; Thermodynamics; Thymine; Uracil | 2009 |
Photoinduced nonadiabatic dynamics of pyrimidine nucleobases: on-the-fly surface-hopping study with semiempirical methods.
Topics: Algorithms; Computational Biology; Cytosine; Models, Molecular; Molecular Conformation; Photochemistry; Pyrimidine Nucleosides; Pyrimidine Nucleotides; Thymine; Uracil | 2009 |
Additive Pummerer reaction of 3,5-O-(di-tert-butyl)silylene-4-thiofuranoid glycal: a high-yield and beta-selective entry to 4'-thioribonucleosides.
Topics: 2-Aminopurine; Cytosine; Purines; Ribonucleosides; Siloxanes; Thionucleosides; Thiophenes; Thymine; Uracil | 2009 |
Chemotaxis to pyrimidines and identification of a cytosine chemoreceptor in Pseudomonas putida.
Topics: Bacterial Proteins; Chemotaxis; Colony Count, Microbial; Cytosine; Gene Deletion; Genetic Complementation Test; Locomotion; Pseudomonas aeruginosa; Pseudomonas putida; Thymine; Uracil | 2009 |
Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand.
Topics: Base Sequence; Guanine; Hydrogen Bonding; Ligands; Thymine; Uracil | 2009 |
[Characteristic vibration analysis of M-RNA nucleic acid bases complexes (M = Ca+ and Mg+) by DFT].
Topics: Calcium; Cations; Cytosine; Humans; Magnesium; Male; Models, Chemical; Nucleic Acid Conformation; Nucleic Acids; Potassium; Pyrimidines; Quantum Theory; RNA; Sodium; Spectrophotometry, Infrared; Spectrum Analysis, Raman; Thymine; Uracil; Vibration | 2009 |
Thymine hydroperoxide as a potential source of singlet molecular oxygen in DNA.
Topics: Anthracenes; DNA; Hydrogen Peroxide; Infrared Rays; Metals; Peroxides; Singlet Oxygen; Sodium Azide; Spectrum Analysis; Sulfonic Acids; Thymine; Uracil | 2009 |
Quintets of uracil and thymine: a novel structure of nucleobase self-assembly studied by electrospray ionization mass spectrometry.
Topics: Cesium; Hydrogen Bonding; Ions; Metals, Alkali; Models, Molecular; Molecular Structure; Potassium; Rubidium; Spectrometry, Mass, Electrospray Ionization; Thymine; Uracil | 2009 |
Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Deoxyguanosine; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Damage; DNA Repair; Escherichia coli; Mutagenesis; Thymine; Transformation, Bacterial; Uracil | 2009 |
Replication across template T/U by human DNA polymerase-iota.
Topics: Binding Sites; Crystallography, X-Ray; DNA; DNA Polymerase iota; DNA Replication; DNA-Directed DNA Polymerase; Glutathione Transferase; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Nucleic Acid Conformation; Oligonucleotides; Protein Binding; Protein Conformation; Recombinant Fusion Proteins; Substrate Specificity; Templates, Genetic; Thymine; Uracil; X-Ray Diffraction | 2009 |
Intersystem crossing and characterization of dark states in the pyrimidine nucleobases uracil, thymine, and 1-methylthymine.
Topics: Electrons; Kinetics; Models, Chemical; Pyrimidines; Quantum Theory; Thermodynamics; Thymine; Uracil | 2009 |
Synthesis and NMR properties of derivatives of 5,6-dihydroborauracil and 5,6-dihydroborathymine.
Topics: Boron Compounds; Magnetic Resonance Spectroscopy; Thymine; Uracil | 2009 |
Initial excited-state structural dynamics of uracil from resonance Raman spectroscopy are different from those of thymine (5-methyluracil).
Topics: Hydrogen Bonding; Spectrum Analysis, Raman; Thymine; Uracil; Vibration | 2009 |
Correlated ab initio study of nucleic acid bases and their tautomers in the gas phase, in a microhydrated environment and in aqueous solution. Part 4. Uracil and thymine.
Topics: Biophysics; Fluorometry; Gases; Models, Chemical; Nucleic Acid Conformation; Nucleic Acids; Solvents; Spectrometry, Fluorescence; Thermodynamics; Thymine; Uracil; Water | 2005 |
Uracil and thymine reactivity in the gas phase: the S(N)2 reaction and implications for electron delocalization in leaving groups.
Topics: Chlorides; DNA; DNA Glycosylases; Electrons; Gases; Organic Chemistry Phenomena; Thymine; Uracil | 2009 |
Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cytosine; Drug Screening Assays, Antitumor; Fluorouracil; HeLa Cells; Humans; Mice; Nucleosides; Stereoisomerism; Thymine; Uracil | 2010 |
Tautomeric equilibrium of uracil and thymine in model protein-nucleic acid contacts. Spectroscopic and quantum chemical approach.
Topics: Carboxylic Acids; Dimethyl Sulfoxide; Isomerism; Nucleic Acids; Protein Binding; Proteins; Protons; Quantum Theory; Sodium Acetate; Spectrum Analysis; Thermodynamics; Thymine; Uracil | 2010 |
High-resolution electron spectroscopy and structures of lithium-nucleobase (adenine, uracil, and thymine) complexes.
Topics: Adenine; Lithium; Macromolecular Substances; Models, Molecular; Molecular Structure; Quantum Theory; Spectrophotometry; Stereoisomerism; Thermodynamics; Thymine; Uracil | 2010 |
Thiothymine (2-thio-5-methyl-uracil).
Topics: Thiouracil; Thymine; Uracil | 1947 |
The synthesis and biological properties of some new thymine and uracil nucleosides.
Topics: Nucleosides; Pyrimidine Nucleosides; Thymine; Uracil | 1947 |
Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer.
Topics: Antimetabolites, Antineoplastic; Drug Combinations; Drug Resistance, Neoplasm; Humans; Immunohistochemistry; Neoplasms; Patient Selection; Pyrimidines; Pyrrolidines; Thymidine Kinase; Thymidylate Synthase; Thymine; Trifluridine; Uracil | 2010 |
Ab initio investigation of the methylation and hydration effects on the electronic spectra of uracil and thymine.
Topics: Methylation; Models, Chemical; Quantum Theory; Thermodynamics; Thymine; Uracil | 2010 |
The UV absorption of nucleobases: semi-classical ab initio spectra simulations.
Topics: Absorption; Adenine; Cytosine; Gases; Guanine; Nucleosides; Quantum Theory; Spectrophotometry, Ultraviolet; Thymine; Uracil | 2010 |
The protein-DNA contacts in RutR•carAB operator complexes.
Topics: Amino Acid Substitution; Binding Sites; Carbon-Nitrogen Ligases; DNA-Binding Proteins; DNA, Bacterial; Escherichia coli Proteins; Ligands; Models, Molecular; Nucleic Acid Conformation; Operator Regions, Genetic; Protein Structure, Tertiary; Thymine; Transcription Factors; Uracil | 2010 |
Covalent hybridization of CNT by thymine and uracil: a computational study.
Topics: Computer Simulation; Models, Molecular; Nanotubes, Carbon; Thymine; Uracil | 2011 |
Synthesis, characterization, and binding property of isoelectronic analogues of nucleobases, B(6)-substituted 5-aza-6-borauracils and -thymines.
Topics: Boron Compounds; Hydrogen Bonding; Molecular Structure; Thymine; Uracil | 2010 |
Mechanical tuning of molecular recognition to discriminate the single-methyl-group difference between thymine and uracil.
Topics: Heterocyclic Compounds; Models, Molecular; Molecular Conformation; Substrate Specificity; Thymine; Uracil | 2010 |
On the molecular basis of uracil recognition in DNA: comparative study of T-A versus U-A structure, dynamics and open base pair kinetics.
Topics: Adenine; Base Pair Mismatch; Base Pairing; DNA; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Sodium; Thymine; Uracil | 2011 |
Hydrogen bonding and structure of uracil-water and thymine-water complexes.
Topics: Hydrogen Bonding; Models, Molecular; Molecular Conformation; Rotation; Spectrum Analysis; Thermodynamics; Thymine; Uracil; Water | 2010 |
Rapid evaluation of the binding energies in hydrogen-bonded amide-thymine and amide-uracil dimers in gas phase.
Topics: Amides; Dimerization; Gases; Hydrogen Bonding; Quantum Theory; Thermodynamics; Thymine; Uracil | 2011 |
Haemopoietic action of 5-methyl uracil (thymine) in tropical sprue.
Topics: Blood; Celiac Disease; Sprue, Tropical; Thymine; Uracil | 1946 |
Thermodynamic contributions of single internal rA·dA, rC·dC, rG·dG and rU·dT mismatches in RNA/DNA duplexes.
Topics: Adenine; Base Pair Mismatch; Cytosine; DNA; Guanine; RNA; Thermodynamics; Thymine; Uracil | 2011 |
Ferrocene-bis(thymine/uracil) conjugates: base pairing directed, spacer dependent self-assembly and supramolecular packing.
Topics: Base Pairing; Crystallography, X-Ray; Ferrous Compounds; Metallocenes; Models, Molecular; Molecular Structure; Thymine; Uracil | 2010 |
Relaxation mechanisms of UV-photoexcited DNA and RNA nucleobases.
Topics: Adenine; Cytosine; DNA; Guanine; Models, Chemical; Molecular Dynamics Simulation; Molecular Structure; Photochemistry; RNA; Thymine; Ultraviolet Rays; Uracil | 2010 |
[Determination of thymine, hypoxanthine and uracil contents in medical pipefish by HPLC].
Topics: Animals; Chromatography, High Pressure Liquid; Hypoxanthine; Medicine, Chinese Traditional; Smegmamorpha; Thymine; Uracil | 2010 |
Efficient synthesis of exomethylene- and keto-exomethylene-d-glucopyranosyl nucleoside analogs as potential cytotoxic agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Fluorouracil; Humans; Inhibitory Concentration 50; Mice; Nucleosides; Thymine; Uracil | 2011 |
A mild phenotype of dihydropyrimidine dehydrogenase deficiency and developmental retardation associated with a missense mutation affecting cofactor binding.
Topics: Amino Acid Sequence; Child; Creatinine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Flavin-Adenine Dinucleotide; Genotype; Humans; Male; Molecular Sequence Data; Mutation, Missense; Protein Binding; Sequence Homology, Amino Acid; Thymine; Uracil | 2011 |
Adsorption of thymine and uracil on 1:1 clay mineral surfaces: comprehensive ab initio study on influence of sodium cation and water.
Topics: Adsorption; Kaolin; Molecular Dynamics Simulation; Sodium; Thermodynamics; Thymine; Uracil; Water | 2011 |
Electrocatalytic oxidation of nucleobases by TiO2 nanobelts.
Topics: Adenine; Catalysis; Cytosine; Electrochemical Techniques; Electrodes; Guanine; Nanotubes; Nucleosides; Oxidation-Reduction; Thymine; Titanium; Uracil | 2011 |
Adsorption of DNA/RNA nucleobases on hexagonal boron nitride sheet: an ab initio study.
Topics: Adenine; Adsorption; Boron Compounds; Cytosine; Guanine; Models, Molecular; Thymine; Uracil | 2011 |
Interaction of minor groove ligands with G-quadruplexes: thermodynamic contributions of the number of quartets, T-U substitutions, and conformation.
Topics: Aptamers, Nucleotide; Binding Sites; Calorimetry; Calorimetry, Differential Scanning; Circular Dichroism; Distamycins; G-Quadruplexes; Guanine; Ligands; Netropsin; Thermodynamics; Thymine; Uracil | 2011 |
Adsorption of adenine, cytosine, thymine, and uracil on sulfide-modified montmorillonite: FT-IR, Mössbauer and EPR spectroscopy and X-ray diffractometry studies.
Topics: Adenine; Adsorption; Bentonite; Cytosine; Earth, Planet; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Kinetics; Manganese Compounds; Oxidation-Reduction; Oxides; Spectroscopy, Fourier Transform Infrared; Sulfides; Thymine; Uracil; X-Ray Diffraction | 2011 |
Rapid cell division contributes to efficient induction of A/T mutations during Ig gene hypermutation.
Topics: Adenine; B-Lymphocytes; Cell Division; Cell Line; Cytidine Deaminase; DNA Mismatch Repair; Germinal Center; Guanine; Humans; Mutation; Reverse Transcriptase Polymerase Chain Reaction; Somatic Hypermutation, Immunoglobulin; Thymine; Uracil | 2011 |
Electron transfer-induced fragmentation of thymine and uracil in atom-molecule collisions.
Topics: Electron Transport; Mass Spectrometry; Potassium; Thymine; Uracil | 2011 |
Solvation of nucleobases in 1,3-dialkylimidazolium acetate ionic liquids: NMR spectroscopy insights into the dissolution mechanism.
Topics: Adenine; Hydrogen Bonding; Imidazoles; Ionic Liquids; Magnetic Resonance Spectroscopy; Solubility; Thymine; Uracil | 2011 |
Can cytosine, thymine and uracil be formed in interstellar regions? A theoretical study.
Topics: Acetaldehyde; Acetylene; Cytosine; Models, Chemical; Nitriles; Temperature; Thymine; Uracil; Urea | 2012 |
Protection of riboflavin and UVB sensitized degradation of DNA and RNA bases by natural antioxidants.
Topics: Adenine; Antioxidants; Ascorbic Acid; Cytosine; DNA; DNA Damage; Glutathione; Guanine; Nucleic Acids; Oxidative Stress; Photolysis; Protective Agents; Purines; Pyrimidines; Riboflavin; RNA; Thymine; Ultraviolet Rays; Uracil | 2012 |
Structural characterization of viral ortholog of human DNA glycosylase NEIL1 bound to thymine glycol or 5-hydroxyuracil-containing DNA.
Topics: Catalytic Domain; Crystallography, X-Ray; DNA; DNA Glycosylases; Humans; Mimiviridae; Oxidation-Reduction; Thymine; Uracil | 2012 |
Nonradiative deactivation mechanisms of uracil, thymine, and 5-fluorouracil: a comparative ab initio study.
Topics: Fluorouracil; Molecular Structure; Photochemical Processes; Quantum Theory; Solutions; Thermodynamics; Thymine; Ultraviolet Rays; Uracil | 2012 |
Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA.
Topics: 5-Methylcytosine; Catalytic Domain; CpG Islands; Crystallography; DNA Repair; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Humans; Mutagenesis; N-Glycosyl Hydrolases; Protein Structure, Tertiary; Substrate Specificity; Thymine; Thymine DNA Glycosylase; Uracil; Uracil-DNA Glycosidase; Water | 2012 |
Cation radii induced structural variation in fluorescent alkaline earth networks constructed from tautomers of a nucleobase analogue.
Topics: Cations; Coordination Complexes; Crystallography, X-Ray; Metals, Alkaline Earth; Molecular Conformation; Porosity; Pyrimidine Nucleosides; Thymine; Uracil | 2012 |
DNA base stacking: the stacked uracil/uracil and thymine/thymine minima.
Topics: Dimerization; DNA; Quantum Theory; Thymine; Uracil | 2012 |
Electron configuration and hydrogen-bonding pattern in several thymine and uracil analogues studied by 1H-14N NQDR and DFT/QTAIM.
Topics: Electrons; Hydrogen; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Nitrogen; Quantum Theory; Thymine; Uracil | 2012 |
Prototropic interactions of pyrimidine nucleic acid bases with acridine: a spectroscopic investigation.
Topics: Acridines; Cytosine; Electron Transport; Lasers; Pyrimidines; Spectrum Analysis; Thymine; Uracil | 2012 |
Structural and functional properties of CiNTH, an endonuclease III homologue of the ascidian Ciona intestinalis: critical role of N-terminal region.
Topics: Amino Acid Sequence; Animals; Ciona intestinalis; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Glycosylases; DNA Repair; Escherichia coli; Gene Expression Regulation; Guanine; Humans; Hydrogen Peroxide; Molecular Sequence Data; Reactive Oxygen Species; Sequence Alignment; Thymine; Uracil | 2012 |
Gas-phase hydration thermochemistry of sodiated and potassiated nucleic acid bases.
Topics: Adenine; Cytosine; Gases; Mass Spectrometry; Potassium; Pyrimidinones; Sodium; Thermodynamics; Thymine; Uracil | 2012 |
Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A.
Topics: 5-Methylcytosine; Cytidine Deaminase; Deamination; DNA; Enzyme Induction; HEK293 Cells; Humans; Immunity, Innate; Interferons; Plasmids; Proteins; Thymine; Uracil | 2012 |
GC-TOF-MS- and CE-TOF-MS-based metabolic profiling of cheonggukjang (fast-fermented bean paste) during fermentation and its correlation with metabolic pathways.
Topics: Carbohydrate Metabolism; Electrophoresis, Capillary; Fermentation; Food Handling; Gas Chromatography-Mass Spectrometry; Glycine max; Guanine; Hypoxanthine; Metabolic Networks and Pathways; Metabolome; Multivariate Analysis; Thymine; Uracil | 2012 |
TAS-102 in refractory colorectal cancer: caution is needed.
Topics: Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Pyrrolidines; Thymine; Trifluridine; Uracil | 2012 |
Physisorption of nucleobases on graphene: a comparative van der Waals study.
Topics: Adenine; Adsorption; Cytosine; Graphite; Guanine; Hydrophobic and Hydrophilic Interactions; Models, Chemical; Quantum Theory; Thymine; Uracil | 2012 |
Stereocontrolled synthesis of 4'-C-cyano and 4'-C-cyano-4'-deoxy pyrimidine pyranonucleosides as potential chemotherapeutic agents.
Topics: Acetylation; Antineoplastic Agents; Cytostatic Agents; Drug Design; Fluorouracil; HeLa Cells; Humans; Inhibitory Concentration 50; Mannose; Nitriles; Oxidation-Reduction; Oxygen; Pyrimidine Nucleosides; Sodium Cyanide; Stereoisomerism; Thymine; Uracil | 2012 |
Selective bond cleavage in potassium collisions with pyrimidine bases of DNA.
Topics: Cations, Monovalent; DNA; Mass Spectrometry; Models, Chemical; Potassium; Pyrimidines; Static Electricity; Thermodynamics; Thymine; Uracil | 2013 |
The use of the GSAM approach for the structural investigation of low-lying isomers of molecular clusters from density-functional-theory-based potential energy surfaces: the structures of microhydrated nucleic acid bases.
Topics: Adenine; Cytosine; Guanine; Isomerism; Models, Molecular; Quantum Theory; Surface Properties; Thermodynamics; Thymine; Uracil; Water | 2013 |
Synthesis of new 1,2,3-triazole derivatives of uracil and thymine with potential inhibitory activity against acidic corrosion of steels.
Topics: Click Chemistry; Corrosion; Electrochemical Techniques; Hydrogen-Ion Concentration; Nuclear Magnetic Resonance, Biomolecular; Steel; Thymine; Triazoles; Uracil | 2013 |
Comparison of high-order harmonic generation in uracil and thymine ablation plumes.
Topics: Infrared Rays; Mass Spectrometry; Silicon; Thymine; Uracil | 2013 |
Side-by-side comparison of DNA damage induced by low-energy electrons and high-energy photons with solid TpTpT trinucleotide.
Topics: Chromatography, High Pressure Liquid; DNA Damage; Electrons; Oligonucleotides; Pentoxyl; Photons; Radiation, Ionizing; Tandem Mass Spectrometry; Thymine; Uracil | 2013 |
Communication: Electronic UV-Vis transient spectra of the ∙OH reaction products of uracil, thymine, cytosine, and 5,6-dihydrouracil by using the complete active space self-consistent field second-order perturbation (CASPT2//CASSCF) theory.
Topics: Cytosine; Electrons; Hydroxyl Radical; Molecular Structure; Quantum Theory; Spectrophotometry, Ultraviolet; Thymine; Uracil | 2013 |
Excited state structures and decay dynamics of 1,3-dimethyluracils in solutions: resonance Raman and quantum mechanical calculation study.
Topics: Acetonitriles; Methanol; Methylation; Models, Molecular; Quantum Theory; Solutions; Solvents; Spectrum Analysis, Raman; Thymine; Ultraviolet Rays; Uracil; Vibration; Water | 2013 |
Non-covalent interactions: complexes of guanidinium with DNA and RNA nucleobases.
Topics: Adenine; Cations; Computer Simulation; Cytosine; DNA; Electrons; Guanidine; Guanine; Hydrogen Bonding; Models, Molecular; RNA; Thymine; Uracil; Water | 2013 |
π- vs σ-radical states of one-electron-oxidized DNA/RNA bases: a density functional theory study.
Topics: Adenine; Cytosine; DNA; Electrons; Gases; Guanine; Models, Molecular; Oxidation-Reduction; RNA; Solutions; Solvents; Thymine; Uracil; Water | 2013 |
Time-resolved photoelectron imaging of the iodide-thymine and iodide-uracil binary cluster systems.
Topics: Electrons; Iodides; Photoelectron Spectroscopy; Thymine; Time Factors; Uracil; Vibration | 2013 |
Structure-wise discrimination of cytosine, thymine, and uracil by proteins in terms of their nonbonded interactions.
Topics: Amino Acids; Cytosine; DNA-Binding Proteins; Hydrogen Bonding; Ligands; Protein Binding; Solvents; Thymine; Uracil | 2014 |
Computational modeling of photoexcitation in DNA single and double strands.
Topics: Adenine; Base Pairing; Cytosine; DNA; DNA, Single-Stranded; Electrons; Energy Transfer; Guanine; Hydrogen Bonding; Models, Theoretical; Nucleic Acid Conformation; Photochemical Processes; Thymine; Uracil | 2015 |
A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine.
Topics: 5-Methylcytosine; Bacterial Proteins; Base Sequence; Cytosine; DNA; Escherichia coli; Gene Expression; Molecular Sequence Data; Mutation; Oligonucleotides; Recombinant Proteins; Substrate Specificity; Thymine; Uracil; Uracil-DNA Glycosidase | 2014 |
Potassium-uracil/thymine ring cleavage enhancement as studied in electron transfer experiments and theoretical calculations.
Topics: DNA; Electron Transport; Potassium; Pyrimidines; Quantum Theory; RNA; Thymine; Uracil | 2014 |
Structures of protonated thymine and uracil and their monohydrated gas-phase ions from ultraviolet action spectroscopy and theory.
Topics: Adenine; Gases; Ions; Models, Chemical; Phase Transition; Protons; Quantum Theory; Spectrophotometry, Ultraviolet; Stereoisomerism; Temperature; Thermodynamics; Thymine; Uracil; Water | 2014 |
Initial excited-state structural dynamics of 5,6-dimethyluracil from resonance Raman spectroscopy.
Topics: Adjuvants, Immunologic; Models, Chemical; Molecular Structure; Spectrum Analysis, Raman; Thymine; Uracil; Vibration | 2014 |
Identification of the glucosyltransferase that converts hydroxymethyluracil to base J in the trypanosomatid genome.
Topics: DNA, Protozoan; Epigenesis, Genetic; Gene Knockout Techniques; Genome, Protozoan; Glucosides; Glucosyltransferases; Mutagenesis, Site-Directed; Pentoxyl; Protozoan Proteins; RNA Interference; RNA, Messenger; RNA, Protozoan; Substrate Specificity; Thymine; Trypanosoma brucei brucei; Uracil | 2014 |
Radiosensitization by thymidine phosphorylase inhibitor in thymidine phosphorylase negative and overexpressing bladder cancer cell lines.
Topics: Cell Line, Tumor; Cell Proliferation; DNA Damage; Drug Combinations; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Pyrrolidines; Radiation-Sensitizing Agents; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil; Urinary Bladder Neoplasms | 2014 |
Understanding the interaction of DNA-RNA nucleobases with different ZnO nanomaterials.
Topics: Adenine; Binding Sites; Cytosine; DNA; Guanine; Models, Chemical; Models, Molecular; Nanostructures; Nanotubes; Quantum Dots; Quantum Theory; RNA; Surface Properties; Thermodynamics; Thymine; Uracil; Zinc Oxide | 2014 |
Solvent evaporation versus proton transfer in nucleobase-Pt(CN)(4,6)²⁻ dianion clusters: a collisional excitation and electronic laser photodissociation spectroscopy study.
Topics: Adenine; Cyanides; Cytosine; DNA; Electrons; Lasers; Photochemistry; Platinum Compounds; Protons; Quantum Theory; Solvents; Spectrophotometry, Infrared; Thymine; Uracil | 2014 |
Real-time analysis of self-assembled nucleobases by Venturi easy ambient sonic-spray ionization mass spectrometry.
Topics: Cations; Ions; Potassium; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Thymine; Time Factors; Uracil | 2014 |
Chemoenzymatic synthesis of C-4'-spiro-oxetanoribonucleosides.
Topics: Molecular Structure; Monosaccharides; Ribonucleosides; Spiro Compounds; Stereoisomerism; Thymine; Uracil | 2014 |
Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA, Neoplasm; Drug Combinations; Male; Mice, Inbred BALB C; Mice, Nude; Pyrrolidines; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2014 |
FT-IR and Raman spectra, ab initio and density functional computations of the vibrational spectra, molecular geometries and atomic charges of uracil and 5-methyluracil (thymine).
Topics: Hydrogen; Hydrogen Bonding; Molecular Conformation; Normal Distribution; Pyrimidines; Quantum Theory; Software; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Temperature; Thymine; Uracil; Vibration | 2015 |
Excitation of nucleobases from a computational perspective II: dynamics.
Topics: Adenine; Cytosine; Electrons; Energy Transfer; Guanine; Models, Theoretical; Molecular Dynamics Simulation; Photochemical Processes; Quantum Theory; Thymine; Ultraviolet Rays; Uracil | 2015 |
Calculations of pKa's and redox potentials of nucleobases with explicit waters and polarizable continuum solvation.
Topics: Adenine; Cations; Cytosine; Guanine; Hydrogen Bonding; Hydrogen-Ion Concentration; Models, Chemical; Models, Genetic; Molecular Structure; Oxidation-Reduction; Protons; Solvents; Thymine; Uracil; Water | 2015 |
Benchmarking coupled cluster methods on singlet excited states of nucleobases.
Topics: Adenine; Computer Simulation; Cytosine; Energy Transfer; Models, Chemical; Models, Molecular; Molecular Structure; Purines; Pyrimidines; Reproducibility of Results; Structure-Activity Relationship; Thymine; Uracil | 2014 |
Communication: Photoactivation of nucleobase bound platinum(II) metal complexes: probing the influence of the nucleobase.
Topics: Adenine; Cytosine; Organoplatinum Compounds; Photochemical Processes; Spectrophotometry, Ultraviolet; Thymine; Uracil; Water | 2014 |
Poly (9-(2-diallylaminoethyl)adenine HCl-co-sulfur dioxide) deposited on silica nanoparticles constructs hierarchically ordered nanocapsules: curcumin conjugated nanocapsules as a novel strategy to amplify guanine selectivity among nucleobases.
Topics: Biosensing Techniques; Curcumin; Cytosine; Guanine; Hydrophobic and Hydrophilic Interactions; Nanocapsules; Nanoparticles; Poly A; Silicon Dioxide; Spectroscopy, Fourier Transform Infrared; Thymine; Uracil | 2015 |
Defective repair of uracil causes telomere defects in mouse hematopoietic cells.
Topics: Animals; Base Sequence; Bone Marrow Cells; Cells, Cultured; DNA Damage; DNA Repair; DNA-Binding Proteins; In Situ Hybridization, Fluorescence; Mice, Knockout; Protein Binding; Shelterin Complex; Telomere; Telomere Homeostasis; Telomere-Binding Proteins; Telomeric Repeat Binding Protein 1; Telomeric Repeat Binding Protein 2; Thymine; Uracil; Uracil-DNA Glycosidase | 2015 |
TD-DFT investigation of the magnetic circular dichroism spectra of some purine and pyrimidine bases of nucleic acids.
Topics: Circular Dichroism; Computer Simulation; Cytosine; Gases; Models, Chemical; Solvents; Thymine; Uracil; Water | 2015 |
Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, with irinotecan hydrochloride on human colorectal and gastric cancer xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Irinotecan; Male; Mice; Pyrrolidines; Stomach Neoplasms; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2015 |
Positron emission tomography imaging of human colon cancer xenografts in mice with [18F]fluorothymidine after TAS-102 treatment.
Topics: Animals; Antineoplastic Agents; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Dideoxynucleosides; Drug Combinations; Female; Fluorine Radioisotopes; HCT116 Cells; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Positron-Emission Tomography; Pyrrolidines; Radiopharmaceuticals; Random Allocation; Thymidine Kinase; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2015 |
Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts.
Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cell Line, Tumor; Cetuximab; Chromatography, Liquid; Colorectal Neoplasms; Disease Models, Animal; Drug Combinations; Humans; Male; Mice; Mice, Nude; Panitumumab; Pyrrolidines; Tandem Mass Spectrometry; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2015 |
Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluridine Using Human Small Intestinal Epithelial Cells.
Topics: Animals; Caco-2 Cells; Carrier Proteins; Cell Line, Tumor; Cell Membrane Permeability; Colorectal Neoplasms; Drug Combinations; Epithelial Cells; Humans; Intestinal Absorption; Intestine, Small; Membrane Transport Proteins; Nucleoside Transport Proteins; Nucleosides; Oocytes; Pyrrolidines; Thymine; Trifluridine; Uracil; Xenopus | 2015 |
Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; DNA, Neoplasm; Drug Combinations; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Fluorouracil; HCT116 Cells; Humans; Male; Pyrophosphatases; Pyrrolidines; Substrate Specificity; Thymidine Kinase; Thymine; Trifluridine; Uracil | 2015 |
Selective Chemical Labeling of Natural T Modifications in DNA.
Topics: Base Sequence; DNA; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Pentoxyl; Thymine; Uracil | 2015 |
Thymidylate synthase inspired biomodel reagent for the conversion of uracil to thymine.
Topics: Biomimetic Materials; Indicators and Reagents; Thymidylate Synthase; Thymine; Uracil | 2015 |
Drug Improves Survival in Refractory Colorectal Cancer.
Topics: Antineoplastic Agents; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Humans; Pyrrolidines; Survival Analysis; Thymine; Treatment Outcome; Trifluridine; Uracil | 2015 |
High-resolution photoelectron spectra of the pyrimidine-type nucleobases.
Topics: Cytosine; Electrons; Gases; Ions; Photochemistry; Photons; Pyrimidines; Thymine; Uracil | 2015 |
Exposure-dependent incorporation of trifluridine into DNA of tumors and white blood cells in tumor-bearing mouse.
Topics: Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA, Neoplasm; Drug Combinations; Humans; Leukocytes; Mice, Nude; Pyrrolidines; Thymine; Trifluridine; Tumor Stem Cell Assay; Uracil | 2015 |
Electron accommodation dynamics in the DNA base thymine.
Topics: Anions; DNA; Electrons; Gases; Photoelectron Spectroscopy; Quaternary Ammonium Compounds; Thymine; Uracil | 2015 |
Electron Detachment as a Probe of Intrinsic Nucleobase Dynamics in Dianion-Nucleobase Clusters: Photoelectron Spectroscopy of the Platinum II Cyanide Dianion Bound to Uracil, Thymine, Cytosine, and Adenine.
Topics: Adenine; Cold Temperature; Cytosine; Electrons; Gases; Organoplatinum Compounds; Photoelectron Spectroscopy; Thymine; Uracil | 2015 |
Efficacy of Combination Chemotherapy Using a Novel Oral Chemotherapeutic Agent, TAS-102, with Oxaliplatin on Human Colorectal and Gastric Cancer Xenografts.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Death; Cell Proliferation; Colorectal Neoplasms; Drug Combinations; HCT116 Cells; Humans; Mice, Nude; Organoplatinum Compounds; Oxaliplatin; Pyrrolidines; Stomach Neoplasms; Thymine; Treatment Outcome; Trifluridine; Tumor Burden; Uracil; Xenograft Model Antitumor Assays | 2015 |
Automated quantum chemistry based molecular dynamics simulations of electron ionization induced fragmentations of the nucleobases Uracil, Thymine, Cytosine, and Guanine.
Topics: Algorithms; Computer Simulation; Cytosine; DNA Fragmentation; Guanine; Models, Chemical; Molecular Dynamics Simulation; Nucleotides; Quantum Theory; Spectrometry, Mass, Electrospray Ionization; Thymine; Uracil | 2015 |
Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
Topics: Base Pair Mismatch; Catalytic Domain; Crystallography, X-Ray; DNA; Humans; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Pentoxyl; Protein Binding; Thymine; Thymine DNA Glycosylase; Uracil | 2015 |
Synthesis of cyclobutane nucleosides 2-preparation of thymine and uracil analogues.
Topics: Chemistry Techniques, Synthetic; Cyclobutanes; Nucleosides; Photochemical Processes; Stereoisomerism; Thymine; Uracil | 2015 |
Toxicity prediction of PHDDs and phenols in the light of nucleic acid bases and DNA base pair interaction.
Topics: Adenine; Base Pairing; Cytosine; DNA; Environmental Pollutants; Guanine; Models, Chemical; Polychlorinated Dibenzodioxins; Quantitative Structure-Activity Relationship; Quantum Theory; Thermodynamics; Thymine; Uracil | 2015 |
Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi.
Topics: Biocatalysis; Catalytic Domain; Fungal Proteins; Ketoglutaric Acids; Mixed Function Oxygenases; Mutagenesis; Neurospora crassa; Pentoxyl; Protein Binding; Substrate Specificity; Thymine; Uracil | 2015 |
[Short-Term Outcome of TAS-102 for Refractory Metastatic Colorectal Cancer].
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Pyrrolidines; Retrospective Studies; Salvage Therapy; Thymine; Treatment Outcome; Trifluridine; Uracil | 2015 |
Insight into the Mechanism of the Initial Reaction of an OH Radical with DNA/RNA Nucleobases: A Computational Investigation of Radiation Damage.
Topics: Adenine; Computer Simulation; DNA; Guanine; Hydroxyl Radical; Kinetics; RNA; Thymine; Uracil | 2015 |
Synthesis of 5-[3-(2-aminopyrimidin-4-yl)aminopropyn-1-yl]uracil derivative that recognizes Ade-Thy base pairs in double-stranded DNA.
Topics: Adenosine; Base Pairing; DNA; Thymine; Uracil | 2016 |
Complete-active-space second-order perturbation theory (CASPT2//CASSCF) study of the dissociative electron attachment in canonical DNA nucleobases caused by low-energy electrons (0-3 eV).
Topics: Adenine; Cytosine; DNA; DNA Breaks; Electrons; Guanine; Hydrogen; Thermodynamics; Thymine; Uracil | 2015 |
A Study of π-π Stacking Interactions and Aromaticity in Polycyclic Aromatic Hydrocarbon/Nucleobase Complexes.
Topics: Adenine; Cytosine; Guanine; Polycyclic Aromatic Hydrocarbons; Quantum Theory; Thymine; Uracil | 2016 |
Safety and Efficacy of Trifluridine/Tipiracil Monotherapy in Clinical Practice for Patients With Metastatic Colorectal Cancer: Experience at a Single Institution.
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Pyrrolidines; Retrospective Studies; Salvage Therapy; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli.
Topics: APOBEC-3G Deaminase; Base Sequence; Cytidine Deaminase; Cytosine; Deamination; DNA; DNA Repair; DNA Replication; DNA, Bacterial; DNA, Single-Stranded; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Humans; Mutation; Recombinant Proteins; Thymine; Uracil; Uracil-DNA Glycosidase | 2016 |
Reliable vibrational wavenumbers for C=O and N-H stretchings of isolated and hydrogen-bonded nucleic acid bases.
Topics: Adenine; Base Pairing; Cytosine; Dimerization; Guanine; Hydrogen; Hydrogen Bonding; Models, Molecular; Nitrogen; Nucleic Acids; Oxygen; Pyrimidinones; Spectrophotometry, Infrared; Thymine; Uracil | 2016 |
Interactions of Some Divalent Metal Ions with Thymine and Uracil Thiosemicarbazide Derivatives.
Topics: Cobalt; Coordination Complexes; Copper; Hydrogen-Ion Concentration; Semicarbazides; Thermodynamics; Thymine; Uracil | 2016 |
Emerging phase 3 data in relapsed/refractory metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Humans; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Recurrence, Local; Phenylurea Compounds; Pyridines; Pyrrolidines; Retreatment; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
Efficacy and Safety of TAS-102 in Clinical Practice of Salvage Chemotherapy for Metastatic Colorectal Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Pyrrolidines; Salvage Therapy; Survival Analysis; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
Combining the GW formalism with the polarizable continuum model: A state-specific non-equilibrium approach.
Topics: Adenine; Cytosine; Electrons; Models, Chemical; Quantum Theory; Solutions; Thermodynamics; Thymine; Uracil | 2016 |
The methyl- and aza-substituent effects on nonradiative decay mechanisms of uracil in water: a transient absorption study in the UV region.
Topics: Absorption, Radiation; Photons; Spectrometry, Fluorescence; Thymine; Ultraviolet Rays; Uracil; Water | 2016 |
UV laser photoactivation of hexachloroplatinate bound to individual nucleobases in vacuo as molecular level probes of a model photopharmaceutical.
Topics: Adenine; Cisplatin; Cytosine; Lasers; Models, Molecular; Photochemical Processes; Radiation-Sensitizing Agents; Thymine; Ultraviolet Rays; Uracil | 2016 |
Safety of an oral anticancer agent (trifluridine/tipiracil combination tablet) in patients with advanced and recurrent colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Drug Combinations; Female; Humans; Male; Middle Aged; Nausea; Neoplasm Recurrence, Local; Neutropenia; Patient Safety; Pyrrolidines; Retrospective Studies; Tablets; Thymine; Trifluridine; Uracil; Vomiting | 2016 |
In brief: trifluridine/tipiracil (Lonsurf) for metastatic colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Enzyme Inhibitors; Humans; Neoplasm Metastasis; Pyrrolidines; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
TAS-102 Safety in Metastatic Colorectal Cancer: Results From the First Postmarketing Surveillance Study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Product Surveillance, Postmarketing; Pyrrolidines; Thymine; Trifluridine; Uracil | 2016 |
TAS-102, the first "cardio-gentle" fluoropyrimidine in the colorectal cancer landscape?
Topics: Cardiotoxicity; Colorectal Neoplasms; Drug Combinations; Humans; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: a cohort study.
Topics: Age Factors; Aged; Antineoplastic Agents; Chemotherapy-Induced Febrile Neutropenia; Clinical Trials, Phase III as Topic; Cohort Studies; Colorectal Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Neoplasm; Female; Humans; Japan; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Pyrrolidines; Thymine; Trifluridine; United States; Uracil | 2016 |
Efficacy and Safety of Regorafenib or TAS-102 in Patients with Metastatic Colorectal Cancer Refractory to Standard Therapies.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
Interactions of Nucleic Acid Bases with Temozolomide. Stacked, Perpendicular, and Coplanar Heterodimers.
Topics: Adenine; Cytosine; Dacarbazine; Dimerization; Guanine; Quantum Theory; Temozolomide; Thymine; Uracil | 2016 |
Neutropenia as a Predictive Factor in Metastatic Colorectal Cancer Treated With TAS-102.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Neutropenia; Prognosis; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil | 2017 |
Microhydration Prevents Fragmentation of Uracil and Thymine by Low-Energy Electrons.
Topics: Electrons; Models, Molecular; Thymine; Uracil | 2016 |
The Role of Aspirin as Antitumoral Agent for Heavily Pretreated Patients With Metastatic Colorectal Cancer Receiving Capecitabine Monotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Capecitabine; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Phenylurea Compounds; Pyridines; Pyrrolidines; Thymine; Trifluridine; Uracil | 2017 |
Regorafenib Versus Trifluridine/Tipiracil for Refractory Metastatic Colorectal Cancer: A Retrospective Comparison.
Topics: Aged; Antineoplastic Agents; Cohort Studies; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Japan; Male; Middle Aged; Neoplasm Metastasis; Phenylurea Compounds; Pyridines; Pyrrolidines; Retrospective Studies; Survival Rate; Thymine; Treatment Outcome; Trifluridine; Uracil | 2017 |
Interstitial pneumonia in a patient treated with TAS-102 for metastatic colorectal cancer: a case report.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Drug Combinations; Humans; Japan; Lung Diseases, Interstitial; Male; Middle Aged; Pyrrolidines; Thymine; Trifluridine; Uracil | 2016 |
Enhanced sensitivity of Neil1
Topics: Animals; Cytokines; DNA Damage; DNA Glycosylases; DNA Repair; Gene Expression Profiling; Gene Expression Regulation; Guanine; Inflammation; Mice; Mice, Knockout; Neutrophil Infiltration; Oxidative Stress; Pyrimidines; Reactive Oxygen Species; Skin; Thymine; Ultraviolet Rays; Uracil | 2016 |
[A Case of Metastatic Colorectal Cancer Refractory to Standard Chemotherapies Treated with TAS-102 with Bevacizumab].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Combined Modality Therapy; Drug Combinations; Female; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Middle Aged; Pyrrolidines; Sigmoid Neoplasms; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
Genetic variants of DNA repair-related genes predict efficacy of TAS-102 in patients with refractory metastatic colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Disease-Free Survival; DNA Repair Enzymes; Drug Combinations; Drug Resistance, Neoplasm; Female; Genetic Association Studies; Humans; Liver Neoplasms; Male; Middle Aged; Phenylurea Compounds; Proportional Hazards Models; Pyridines; Pyrrolidines; Retrospective Studies; Thymine; Treatment Outcome; Trifluridine; Uracil | 2017 |
A comparative study on the experimental and calculated results of mid-infrared and Raman vibrational modes of nucleic acid bases.
Topics: Adenine; Crystallization; Cytosine; Guanine; Hydrogen Bonding; Molecular Conformation; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thymine; Uracil | 2017 |
Panitumumab interaction with TAS-102 leads to combinational anticancer effects via blocking of EGFR-mediated tumor response to trifluridine.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Panitumumab; Pyrrolidines; Thymine; Trifluridine; Uracil | 2017 |
The influence of substituents and the environment on the NMR shielding constants of supramolecular complexes based on A-T and A-U base pairs.
Topics: Adenine; Base Pairing; DNA; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Structure; Potassium; RNA; Thymine; Uracil | 2017 |
The Formation of Nucleobases from the Ultraviolet Photoirradiation of Purine in Simple Astrophysical Ice Analogues.
Topics: Exobiology; Ice; Purine Nucleosides; Purines; Thymine; Ultraviolet Rays; Uracil | 2017 |
New perspectives for TAS-102: TASK successful?
Topics: Drug Combinations; Pyrrolidines; Thymine; Trifluridine; Uracil | 2017 |
Propensity Score Analysis of Regorafenib Versus Trifluridine/Tipiracil in Patients with Metastatic Colorectal Cancer Refractory to Standard Chemotherapy (REGOTAS): A Japanese Society for Cancer of the Colon and Rectum Multicenter Observational Study.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Japan; Liver Neoplasms; Male; Middle Aged; Phenylurea Compounds; Prognosis; Propensity Score; Pyridines; Pyrrolidines; Retrospective Studies; Salvage Therapy; Survival Rate; Thymine; Trifluridine; Uracil | 2018 |
Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer.
Topics: Antineoplastic Agents; California; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Equilibrative Nucleoside Transporter 1; Female; Gene Frequency; Genotype; Humans; Italy; Japan; Male; Neoplasm Metastasis; Organic Cation Transport Proteins; Organic Cation Transporter 2; Pharmacogenetics; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Polymorphism, Single Nucleotide; Predictive Value of Tests; Pyrrolidines; Retrospective Studies; Thymine; Treatment Outcome; Trifluridine; Uracil | 2017 |
Cost-effectiveness of Trifluridine/tipiracil for Previously Treated Metastatic Colorectal Cancer in England and Wales.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Cost-Benefit Analysis; Drug Combinations; England; Female; Humans; Male; Middle Aged; Phenylurea Compounds; Pyridines; Pyrrolidines; Randomized Controlled Trials as Topic; Salvage Therapy; Thymine; Trifluridine; Uracil; Wales | 2018 |
Integrated safety summary for trifluridine/tipiracil (TAS-102).
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Trifluridine; Uracil | 2018 |
Feasibility and effectiveness of trifluridine/tipiracil in metastatic colorectal cancer: real-life data from The Netherlands.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Leukopenia; Male; Middle Aged; Netherlands; Neutropenia; Prognosis; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Bone Marrow Cells; Colorectal Neoplasms; DNA; Drug Combinations; HCT116 Cells; Humans; Leukocytes, Mononuclear; Male; Mice, Inbred BALB C; Phytohemagglutinins; Pyrrolidines; Spleen; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2017 |
TAS-102 in metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Drug Combinations; Humans; Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
Dynamics of the excised base release in thymine DNA glycosylase during DNA repair process.
Topics: Biocatalysis; Catalytic Domain; Cytosine; DNA; DNA Repair; Humans; Markov Chains; Molecular Docking Simulation; Mutation, Missense; Thymine; Thymine DNA Glycosylase; Uracil | 2018 |
Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli.
Topics: Bacteria; Escherichia coli; Escherichia coli Proteins; Membrane Transport Proteins; Molecular Docking Simulation; Multigene Family; Operon; Phylogeny; Pyrimidines; Substrate Specificity; Thymine; Uracil | 2018 |
Severe neutropenia: a prognosticator in patients with advanced/recurrent colorectal cancer
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Prognosis; Pyrrolidines; Risk Factors; Survival Analysis; Thymine; Trifluridine; Uracil | 2017 |
Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR.
Topics: Cyclization; Humans; Hydrogen Bonding; Imidazoles; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Small Molecule Libraries; Thymine; Uracil | 2018 |
Evaluating trifluridine + tipiracil hydrochloride in a fixed combination (TAS-102) for the treatment of colorectal cancer.
Topics: Colorectal Neoplasms; Drug Combinations; Humans; Prognosis; Pyrrolidines; Thymine; Trifluridine; Uracil | 2018 |
Risk factors contributing to the development of neutropenia in patients receiving oral trifluridine-tipiracil (TAS-102) chemotherapy for advanced/recurrent colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Creatinine; Drug Combinations; Female; Humans; Leukocyte Count; Male; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Neutrophils; Pyrrolidines; Retrospective Studies; Risk Factors; Thymine; Trifluridine; Uracil | 2018 |
Reply to P. Di Nardo et al and R. Sun et al.
Topics: Colonic Neoplasms; Double-Blind Method; Drug Combinations; Humans; Pyrrolidines; Thymine; Trifluridine; Uracil | 2018 |
Interpreting the Benefit of Trifluridine/Tipiracil in Metastatic Colorectal Cancer With Respect to Progression-Free Survival and Overall Survival.
Topics: Colorectal Neoplasms; Double-Blind Method; Drug Combinations; Humans; Progression-Free Survival; Pyrrolidines; Respect; Thymine; Trifluridine; Uracil | 2018 |
Statistical and Clinical Significance in the TERRA Study.
Topics: Double-Blind Method; Drug Combinations; Humans; Pyrrolidines; RNA, Long Noncoding; Telomere; Thymine; Trifluridine; Uracil | 2018 |
Triplex Formation by Oligonucleotides Containing Organomercurated Base Moieties.
Topics: Base Pairing; Base Sequence; Circular Dichroism; Cytosine; Mercury; Nucleic Acid Conformation; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Oligonucleotides; Thymine; Uracil | 2018 |
Usefulness of TAS-102 as Third-line Chemotherapy for Metastatic Colorectal Cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Combinations; Feasibility Studies; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Pyrrolidines; Retrospective Studies; Salvage Therapy; Survival Analysis; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
[Safety and Efficacy of TAS-102 with Bevacizumab for the Treatment of Unresectable Metastatic Colorectal Cancer - A Case Report].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Drug Combinations; Humans; Liver Neoplasms; Male; Pyrrolidines; Rectal Neoplasms; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
Synthesis of novel 3'-azido-3'-deoxy-α-L-ribo configured nucleosides: A comparative study between chemical and chemo-enzymatic methodologies.
Topics: Azides; Catalysis; Enzymes; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleosides; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Structure-Activity Relationship; Thymine; Uracil | 2018 |
Trifluridine/Tipiracil (TAS-102) in Refractory Metastatic Colorectal Cancer: A Multicenter Register in the Frame of the Italian Compassionate Use Program.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Drug Combinations; Female; Humans; Italy; Male; Middle Aged; Progression-Free Survival; Pyrrolidines; Registries; Thymine; Trifluridine; Uracil | 2018 |
Real-world Treatment Patterns Among Patients With Colorectal Cancer Treated With Trifluridine/Tipiracil and Regorafenib.
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Disease Progression; Drug Combinations; Drug Resistance, Neoplasm; Female; Humans; Kaplan-Meier Estimate; Male; Medication Adherence; Middle Aged; Phenylurea Compounds; Pyridines; Pyrrolidines; Retrospective Studies; Thymine; Treatment Outcome; Trifluridine; United States; Uracil | 2018 |
How I treat chemorefractory metastatic colorectal cancer.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Lymphatic Metastasis; Neoplasm Staging; Nivolumab; Phenylurea Compounds; Prognosis; Proto-Oncogene Proteins B-raf; Pyridines; Pyrrolidines; Quinazolines; Randomized Controlled Trials as Topic; Survival Analysis; Thymine; Trastuzumab; Trifluridine; Uracil; Vascular Endothelial Growth Factor Receptor-1 | 2018 |
Biweekly Administration of TAS-102 for Neutropenia Prevention in Patients with Colorectal Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Male; Middle Aged; Neutropenia; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil | 2018 |
Unscheduled DNA synthesis leads to elevated uracil residues at highly transcribed genomic loci in Saccharomyces cerevisiae.
Topics: Cell Cycle; DNA Damage; DNA Replication; DNA, Fungal; Fungal Proteins; Genomic Instability; Genomics; Mutagenesis; Pyrophosphatases; Saccharomyces cerevisiae; Thymine; Transcription, Genetic; Uracil | 2018 |
Optimizing Treatment Sequence for Late-line Metastatic Colorectal Cancer Patients Using Trifluridine/Tipiracil and Regorafenib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Drug Combinations; Female; Follow-Up Studies; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Phenylurea Compounds; Prognosis; Pyridines; Pyrrolidines; Retrospective Studies; Survival Rate; Thymine; Trifluridine; Uracil | 2018 |
Experimental and Theoretical Study on the Cycloreversion of a Nucleobase-Derived Azetidine by Photoinduced Electron Transfer.
Topics: Aza Compounds; Azetidines; Cycloaddition Reaction; Electron Transport; Models, Molecular; Oxidation-Reduction; Photochemical Processes; Pyrimidine Dimers; Pyrimidines; Thymine; Uracil | 2018 |
Role of Predictive Value of the Modified Glasgow Prognostic Score for Later-line Chemotherapy in Patients With Metastatic Colorectal Cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; C-Reactive Protein; Colorectal Neoplasms; Drug Combinations; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Middle Aged; Nutritional Status; Phenylurea Compounds; Prognosis; Pyridines; Pyrrolidines; Retrospective Studies; Serum Albumin, Human; Survival Rate; Thymine; Trifluridine; Uracil | 2018 |
[Two Cases of Long-Term Use of TAS-102 for Unresectable Colorectal Cancer].
Topics: Aged, 80 and over; Appendiceal Neoplasms; Drug Combinations; Female; Humans; Male; Pyrrolidines; Rectal Neoplasms; Recurrence; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
Relationship Between Thymidine Kinase 1 Expression and Trifluridine/Tipiracil Therapy in Refractory Metastatic Colorectal Cancer: A Pooled Analysis of 2 Randomized Clinical Trials.
Topics: Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Prognosis; Pyrrolidines; Randomized Controlled Trials as Topic; Salvage Therapy; Survival Rate; Thymidine Kinase; Thymine; Trifluridine; Uracil | 2018 |
Thermodynamic Stability of DNA Duplexes Comprising the Simplest T → dU Substitutions.
Topics: Base Pairing; DNA; Mutation; Nucleic Acid Conformation; Sodium Chloride; Thermodynamics; Thymine; Uracil; Uracil-DNA Glycosidase; Water | 2018 |
[A Case of Interstitial Pneumonitis Induced by TAS-102 for Liver and Lung Metastasis of Colorectal Cancer].
Topics: Aged; Drug Combinations; Humans; Liver Neoplasms; Lung Diseases, Interstitial; Lung Neoplasms; Male; Pyrrolidines; Rectal Neoplasms; Sigmoid Neoplasms; Thymine; Treatment Outcome; Trifluridine; Uracil | 2018 |
On the Cooperativity Effect in Watson and Crick and Wobble Pairs for a Halouracil Series and Its Potential Quantitative Application Studied through Surface-Enhanced Raman Spectroscopy.
Topics: Base Pairing; Bromouracil; Gold; Least-Squares Analysis; Limit of Detection; Metal Nanoparticles; Nucleic Acid Conformation; Principal Component Analysis; Spectrum Analysis, Raman; Thymine; Uracil | 2018 |
Low Skeletal Muscle Mass before Salvage-Line Chemotherapy Is a Poor Prognostic Factor in Patients with Refractory Metastatic Colorectal Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Muscle, Skeletal; Phenylurea Compounds; Prognosis; Proportional Hazards Models; Pyridines; Pyrrolidines; Retrospective Studies; Salvage Therapy; Thymine; Treatment Outcome; Trifluridine; Uracil | 2019 |
Ionization and Electron Attachment for Nucleobases in Water.
Topics: Adenine; Cytosine; Electrons; Guanine; Molecular Dynamics Simulation; Oxidation-Reduction; Quantum Theory; Thymine; Uracil; Water | 2019 |
Evaluation of Tolerability of Trifluridine/Tipiracil Combination Tablet in Patients With Advanced/Recurrent Colorectal Cancer.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Nausea; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neutropenia; Pyrrolidines; Retrospective Studies; Tablets; Thymine; Treatment Outcome; Trifluridine; Uracil | 2019 |
Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Catalysis; Demethylation; Deoxyadenosines; DNA, Single-Stranded; Epigenesis, Genetic; Humans; Nucleic Acid Conformation; Protein Conformation; Protein Structure, Tertiary; RNA; RNA, Messenger; Substrate Specificity; Thymine; Uracil | 2019 |
Time-resolved radiation chemistry: femtosecond photoelectron spectroscopy of electron attachment and photodissociation dynamics in iodide-nucleobase clusters.
Topics: Adenine; Cytosine; Electrons; Iodides; Lasers; Photoelectron Spectroscopy; Photolysis; Quantum Theory; Thymine; Uracil | 2019 |
Melting of nucleobases. Getting the cutting edge of "Walden's Rule".
Topics: Adenine; Cytosine; Guanine; Hot Temperature; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Phase Transition; Surface Properties; Thermodynamics; Thymine; Uracil | 2019 |
Fluoropyrimidines and DPD testing: is there truly an inexorable link?
Topics: Antineoplastic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Genotype; Humans; Neoplasms; Oxonic Acid; Pharmacogenomic Testing; Phenotype; Point-of-Care Testing; Pyrrolidines; Tegafur; Thymine; Trifluridine; Uracil | 2019 |
Thermochemistry of Uracil, Thymine, Cytosine, and Adenine.
Topics: Adenine; Cytosine; Quantum Theory; Temperature; Thymine; Uracil | 2019 |
The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks.
Topics: Cell Cycle; DNA; DNA Glycosylases; DNA Replication; DNA, Single-Stranded; Humans; Models, Genetic; N-Glycosyl Hydrolases; Thymine; Uracil | 2019 |
Cost-effectiveness of trifluridine/tipiracil (TAS102) for heavily pretreated metastatic gastric cancer.
Topics: Clinical Trials as Topic; Cost-Benefit Analysis; Drug Combinations; Drug Costs; Humans; Markov Chains; Progression-Free Survival; Pyrrolidines; Quality-Adjusted Life Years; Stomach Neoplasms; Thymine; Trifluridine; Uracil | 2020 |
Efficacy and safety of trifluridine/tipiracil in third-line and beyond for the treatment of patients with metastatic colorectal cancer in routine clinical practice: patterns of use and prognostic nomogram.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Nomograms; Prognosis; Progression-Free Survival; Pyrrolidines; Response Evaluation Criteria in Solid Tumors; Retrospective Studies; Spain; Survival Rate; Thymine; Trifluridine; Uracil | 2020 |
Vibrational investigation of nucleobases by means of divide and conquer semiclassical dynamics.
Topics: Adenine; Cytosine; Density Functional Theory; Isomerism; Models, Chemical; Molecular Dynamics Simulation; Thymine; Uracil; Vibration | 2019 |
Trifluridine/Tipiracil (TAS-102) for refractory metastatic colorectal cancer in clinical practice: a feasible alternative for patients with good performance status.
Topics: Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Drug Administration Schedule; Drug Combinations; Feasibility Studies; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Progression-Free Survival; Pyrrolidines; Rectal Neoplasms; Retrospective Studies; Severity of Illness Index; Thymine; Treatment Outcome; Trifluridine; Uracil | 2019 |
Bacterial Nucleobases Synergistically Induce Larval Settlement and Metamorphosis in the Invasive Mussel
Topics: Animals; Bivalvia; Guanine; Larva; Metamorphosis, Biological; Seawater; Thymine; Uracil; Vibrio; Xanthine | 2019 |
The Onset of Grade ≥3 Neutropenia Is Associated With Longer Overall Survival in Metastatic Colorectal Cancer Patients Treated With Trifluridine/Tipiracil.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Neutropenia; Pyrrolidines; Survival Analysis; Thymine; Trifluridine; Uracil | 2019 |
Pretreatment Neutrophil-to-Lymphocyte Ratio Predicts Survival After TAS-102 Treatment of Patients With Metastatic Colorectal Cancer.
Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Colorectal Neoplasms; Drug Combinations; Female; Humans; Leukocyte Count; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Neoplasm Metastasis; Neutrophils; Platelet Count; Prognosis; Progression-Free Survival; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil | 2019 |
Safety Report of TAS-102 in a Patient With Reduced DPD Activity.
Topics: Aged; Antineoplastic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Resistance, Neoplasm; Female; Humans; Patient Safety; Prognosis; Pyrrolidines; Rectal Neoplasms; Thymine; Trifluridine; Uracil | 2019 |
Nucleobase synthesis in interstellar ices.
Topics: Adenine; Ammonia; Carbon Monoxide; Cytosine; Evolution, Chemical; Extraterrestrial Environment; Hypoxanthine; Ice; Methanol; Molecular Structure; Photochemical Processes; Thymine; Ultraviolet Rays; Uracil; Water; Xanthine | 2019 |
Real-world use of trifluridine/tipiracil for patients with metastatic colorectal cancer in Canada.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Canada; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Pyrrolidines; Thymine; Trifluridine; Uracil | 2019 |
Sequencing beyond the second-line setting in metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Humans; Neoplasm Metastasis; Phenylurea Compounds; Prognosis; Pyridines; Pyrrolidines; Salvage Therapy; Survival Rate; Thymine; Trifluridine; Uracil | 2019 |
Prognostic scores for evaluating the survival benefit of regorafenib or trifluridine/tipiracil in patients with metastatic colorectal cancer: an exploratory analysis of the REGOTAS study.
Topics: Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Combinations; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Phenylurea Compounds; Pyridines; Pyrrolidines; Retrospective Studies; Thymine; Treatment Outcome; Trifluridine; Uracil | 2020 |
Sublimation thermodynamics of nucleobases derived from fast scanning calorimetry.
Topics: Adenine; Calorimetry; Cytosine; Guanine; Pressure; Thermodynamics; Thymine; Uracil; Volatilization | 2020 |
Should we optimize cytotoxic therapy by dosing to neutropenia? Lessons from TAS-102.
Topics: Colorectal Neoplasms; Drug Combinations; Humans; Neutropenia; Pyrrolidines; Thymine; Trifluridine; Uracil | 2020 |
TAS-102 plus bevacizumab: a new standard for metastatic colorectal cancer?
Topics: Bevacizumab; Drug Combinations; Humans; Pyrrolidines; Rectal Neoplasms; Thymine; Trifluridine; Uracil | 2020 |
Review of metastatic colorectal cancer treatment pathways and early clinical experience of trifluridine/tipiracil in the UK named patient programme.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; United Kingdom; Uracil | 2020 |
Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes.
Topics: Animals; DNA-Binding Proteins; DNA, Kinetoplast; Genes, Protozoan; Glucosides; Glucosyltransferases; Histones; Leishmania; Mutation; Protozoan Proteins; RNA Interference; RNA Polymerase II; Thymine; Transcription Termination, Genetic; Trypanosoma brucei brucei; Uracil | 2020 |
Bevacizumab in Combination with TAS-102 Improves Clinical Outcomes in Patients with Refractory Metastatic Colorectal Cancer: A Retrospective Study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Humans; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil | 2020 |
Chemo-enzymatic route to bridged homolyxofuranosyl-pyrimidines.
Topics: Carbohydrate Conformation; Pyrimidine Nucleosides; Thymine; Uracil | 2020 |
Trifluridine/tipiracil: A practical guide to its use in the management of refractory metastatic colorectal cancer in Australia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Australia; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Prognosis; Pyrrolidines; Quality of Life; Thymine; Trifluridine; Uracil | 2020 |
TAS-102 plus bevacizumab in metastatic colorectal cancer.
Topics: Bevacizumab; Drug Combinations; Humans; Pyrrolidines; Rectal Neoplasms; Thymine; Trifluridine; Uracil | 2020 |
TAS-102 plus bevacizumab in metastatic colorectal cancer - Authors' reply.
Topics: Bevacizumab; Drug Combinations; Humans; Pyrrolidines; Rectal Neoplasms; Thymine; Trifluridine; Uracil | 2020 |
Impact of tumour growth rate during preceding treatment on tumour response to regorafenib or trifluridine/tipiracil in refractory metastatic colorectal cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Decision-Making; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Phenylurea Compounds; Progression-Free Survival; Pyridines; Pyrrolidines; Retrospective Studies; Thymine; Time Factors; Trifluridine; Tumor Burden; Uracil | 2019 |
Economic Sustainability of Trifluridine/Tipiracil for the Treatment of Refractory Metastatic Colorectal Cancer in Real Life.
Topics: Colorectal Neoplasms; Cost-Benefit Analysis; Drug Combinations; England; Humans; Pyrrolidines; Thymine; Trifluridine; Uracil; Wales | 2020 |
Regorafenib vs trifluridine/tipiracil for metastatic colorectal cancer refractory to standard chemotherapies: A multicenter retrospective comparison study in Japan.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Female; Humans; Japan; Male; Middle Aged; Phenylurea Compounds; Progression-Free Survival; Pyridines; Pyrrolidines; Retrospective Studies; Salvage Therapy; Thymine; Treatment Outcome; Trifluridine; Uracil | 2020 |
First-principles characterization of the singlet excited state manifold in DNA/RNA nucleobases.
Topics: Adenine; Cytosine; Density Functional Theory; DNA; Guanine; RNA; Thymine; Uracil | 2020 |
Combining Bevacizumab With Trifluridine/Thymidine Phosphorylase Inhibitor Improves the Survival Outcomes Regardless of the Usage History of Bevacizumab in Front-line Treatment of Patients With Metastatic Colorectal Cancer.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Pyrrolidines; Survival Analysis; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil; Young Adult | 2020 |
Frequency and hydrogen bonding of nucleobase homopairs in small molecule crystals.
Topics: Adenine; Base Pairing; Crystallography, X-Ray; Cytosine; Databases, Protein; Guanine; Hydrogen Bonding; Hypoxanthine; Molecular Structure; Protein Conformation; Proteins; Small Molecule Libraries; Thymine; Uracil | 2020 |
Experimental and theoretical studies on thymine photodimerization mediated by oxidatively generated DNA lesions and epigenetic intermediates.
Topics: Cytosine; Dimerization; DNA Damage; Epigenesis, Genetic; Oxidation-Reduction; Photochemistry; Sunlight; Thymine; Ultraviolet Rays; Uracil | 2020 |
Probing the molecular frame of uracil and thymine with high-harmonic generation spectroscopy.
Topics: Models, Chemical; Quantum Theory; Spectrum Analysis; Thymine; Uracil | 2021 |
[Long-Term Survivor with Recurrent Gastric Cancer Using Trifluridine/Tipiracil as a Late-Line Chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Humans; Neoplasm Recurrence, Local; Pyrrolidines; Stomach Neoplasms; Survivors; Thymine; Trifluridine; Uracil | 2020 |
Quantum Simulation of the Silicene and Germanene for Sensing and Sequencing of DNA/RNA Nucleobases.
Topics: Adenine; Adsorption; Biosensing Techniques; Computer Simulation; Cytosine; DNA; Germanium; Guanine; RNA; Silicon; Thymine; Uracil | 2021 |
[Two Cases of Metastatic Colorectal Cancer Treated with TAS-102 plus Bevacizumab].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Humans; Neoplasm Recurrence, Local; Pyrrolidines; Thymine; Trifluridine; Uracil | 2021 |
Nonadiabatic Absorption Spectra and Ultrafast Dynamics of DNA and RNA Photoexcited Nucleobases.
Topics: Adenine; Cytosine; DNA; Models, Chemical; RNA; Thymine; Uracil | 2021 |
Prebiotic Route to Thymine from Formamide-A Combined Experimental-Theoretical Study.
Topics: Formamides; Origin of Life; Thymine; Uracil | 2021 |
RNA Editing of the Human DNA Glycosylase NEIL1 Alters Its Removal of 5-Hydroxyuracil Lesions in DNA.
Topics: DNA; DNA Glycosylases; DNA Repair; DNA, Single-Stranded; Humans; Oxidation-Reduction; RNA Editing; Thymine; Uracil | 2021 |
Overexpression and characterization of Escherichia coli dihydropyrimidine dehydrogenase: a four iron-sulphur cluster containing flavoprotein.
Topics: Animals; Catalysis; Dihydrouracil Dehydrogenase (NADP); Escherichia coli; Escherichia coli Proteins; Flavins; Flavoproteins; Histidine; Iron; Iron-Sulfur Proteins; Kinetics; Oligopeptides; Sulfur; Swine; Thymine; Uracil | 2021 |
Cost-effectiveness of trifluridine/tipiracil against nivolumab for heavily pretreated metastatic gastric cancer in Japan.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Cost-Benefit Analysis; Drug Combinations; Humans; Japan; Nivolumab; Pyrrolidines; Stomach Neoplasms; Thymine; Trifluridine; Uracil | 2021 |
Trifluridine/tipiracil versus placebo for third or later lines of treatment in metastatic gastric cancer: an exploratory subgroup analysis from the TAGS study.
Topics: Colorectal Neoplasms; Humans; Pyrrolidines; Stomach Neoplasms; Thymine; Trifluridine; Uracil | 2021 |
Retrospective Study of Regorafenib Versus TAS-102 Efficacy and Safety in Chemorefractory Metastatic Colorectal Cancer (mCRC) Patients: A Multi-institution Real Life Clinical Data.
Topics: Colorectal Neoplasms; Drug Combinations; Humans; Phenylurea Compounds; Pyridines; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil | 2021 |
Initial experience of TAS-102 chemotherapy in Australian patients with Chemo-refractory metastatic colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Australia; Colonic Neoplasms; Colorectal Neoplasms; Drug Combinations; Humans; Middle Aged; Neoplasm Recurrence, Local; Pyrrolidines; Rectal Neoplasms; Retrospective Studies; Thymine; Trifluridine; Uracil | 2022 |
Unexpected Reaction Products of Uracil and Its Methyl Derivatives with Acetic Anhydride and Methylene Chloride.
Topics: Acetic Anhydrides; Methylene Chloride; Thymine; Uracil | 2021 |
Trifluridine/Tipiracil in Metastatic Colorectal Cancer: A UK Multicenter Real-world Analysis on Efficacy, Safety, Predictive and Prognostic Factors.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Humans; Prognosis; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil | 2021 |
Selective sensing of the nucleoside analogue, trifluridine and tipiracil in dosage form and biological matrices.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Combinations; Humans; Nucleosides; Pyrrolidines; Thymine; Trifluridine; Uracil | 2022 |
Enhanced Triplex Hybridization of DNA and RNA via Syndiotactic Side Chain Presentation in Minimal bPNAs.
Topics: DNA; Nucleic Acid Conformation; Nucleic Acid Hybridization; Peptide Nucleic Acids; RNA; Thermodynamics; Thymine; Uracil | 2022 |
Trifluridine/Tipiracil in Combination with Bevacizumab in First-Line for Metastatic Colorectal Cancer: A Way Forward. A Point of View Based on Cost-Effectiveness.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colonic Neoplasms; Colorectal Neoplasms; Cost-Benefit Analysis; Drug Combinations; Humans; Pyrrolidines; Rectal Neoplasms; Thymine; Trifluridine; Uracil | 2022 |
Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase.
Topics: Cytosine; DNA; DNA Repair; Humans; Oligonucleotides; Substrate Specificity; Tandem Mass Spectrometry; Thymine; Thymine DNA Glycosylase; Uracil | 2022 |
The effect of prognostic factors at baseline on the efficacy of trifluridine/tipiracil in patients with metastatic colorectal cancer: A Portuguese exploratory analysis.
Topics: Aged; Colonic Neoplasms; Colorectal Neoplasms; Female; Humans; Liver Neoplasms; Male; Portugal; Prognosis; Pyrrolidines; Rectal Neoplasms; Retrospective Studies; Thymine; Trifluridine; Uracil | 2022 |
Sequential Treatment With Trifluridine/Tipiracil and Regorafenib in Refractory Metastatic Colorectal Cancer Patients: An AGEO Prospective "Real-World Study".
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colorectal Neoplasms; Drug Combinations; Frontotemporal Dementia; Humans; Phenylurea Compounds; Prospective Studies; Pyridines; Pyrrolidines; Rectal Neoplasms; Thymine; Trifluridine; Uracil | 2022 |
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5.
Topics: Aeropyrum; DNA-(Apurinic or Apyrimidinic Site) Lyase; Thermococcus; Thymine; Uracil | 2022 |
Influence of precedent drug on the subsequent therapy in the sequence of trifluridine/tipiracil with/out bevacizumab and regorafenib for unresectable or recurrent colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Humans; Neoplasm Recurrence, Local; Phenylurea Compounds; Pyridines; Pyrrolidines; Thymine; Trifluridine; Uracil | 2022 |
Phylogenic analysis of new viral cluster of large phages with unusual DNA genomes containing uracil in place of thymine in gene-sharing network, using phages S6 and PBS1 and relevant uncultured phages derived from sewage metagenomics.
Topics: Bacteriophages; DNA; DNA, Viral; Genome, Viral; Metagenomics; Myoviridae; Phylogeny; Sewage; Thymine; Uracil | 2022 |
Interaction of glucosamine with uracil and thymine: a computational study.
Topics: Glucosamine; Quantum Theory; Solvents; Thymine; Uracil; Water | 2022 |
Efficacy, safety and prognostic factors in patients with refractory metastatic colorectal cancer treated with trifluridine/tipiracil plus bevacizumab in a real-world setting.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colonic Neoplasms; Colorectal Neoplasms; Drug Combinations; Humans; Middle Aged; Prognosis; Pyrrolidines; Rectal Neoplasms; Retrospective Studies; Thymine; Trifluridine; Uracil | 2022 |
Quantification of uracil, dihydrouracil, thymine and dihydrothymine for reliable dihydropyrimidine dehydrogenase (DPD) phenotyping critically depend on blood and plasma storage conditions.
Topics: Biomarkers; Capecitabine; Chromatography, Liquid; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Tandem Mass Spectrometry; Thymine; Uracil | 2022 |
Quantitation of Pyrimidine in Urine by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry.
Topics: Biomarkers; Chromatography, Liquid; Dihydropyrimidine Dehydrogenase Deficiency; Humans; Pyrimidines; Tandem Mass Spectrometry; Thymidine; Thymine; Uracil | 2022 |
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase.
Topics: 5-Methylcytosine; Cytosine; DNA; DNA Repair; Humans; Oxidative Stress; Pedobacter; Thymine; Thymine DNA Glycosylase; Uracil; Uracil-DNA Glycosidase | 2022 |
Identification of fungal dihydrouracil-oxidase genes by expression in Saccharomyces cerevisiae.
Topics: Cell Extracts; Genes, Fungal; Hydrogen; Hydrogen Peroxide; NAD; Proteome; Saccharomyces cerevisiae; Thymine; Uracil | 2022 |
3-Methylation alters excited state decay in photoionised uracil.
Topics: Methylation; RNA; Thymine; Uracil | 2022 |
Rapid excision of oxidized adenine by human thymine DNA glycosylase.
Topics: Adenine; DNA; DNA Repair; Escherichia coli; Humans; Substrate Specificity; Thymine; Thymine DNA Glycosylase; Uracil | 2023 |
Adenine selected hydrogelation of vitamin B2 with amplified circularly polarized luminescence.
Topics: Adenine; Luminescence; Riboflavin; Thymine; Uracil | 2023 |
Regorafenib is suitable for advanced colorectal cancer patients who have previously received trifluridine/tipiracil plus bevacizumab.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Female; Humans; Male; Middle Aged; Phenylurea Compounds; Pyrrolidines; Retrospective Studies; Thymine; Trifluridine; Uracil | 2023 |
Chemoenzymatic synthesis of bridged homolyxofuranosyl pyrimidine nucleosides: Bicyclic AZT analogues.
Topics: Antiviral Agents; Nucleosides; Pyrimidine Nucleosides; Thymine; Uracil | 2023 |
Distant sequence regions of JBP1 contribute to J-DNA binding.
Topics: Carrier Proteins; DNA; Mixed Function Oxygenases; Thymidine; Thymine; Uracil | 2023 |
Register-Shifted Structures in Base-Flipped Uracil-Damaged DNA.
Topics: DNA; DNA Damage; DNA Repair; Thymine; Uracil; Uracil-DNA Glycosidase | 2023 |
Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism.
Topics: Antimetabolites; Cytarabine; Floxuridine; Fluorouracil; Gemcitabine; Nucleosides; Pyrimidines; Tetrahymena thermophila; Thymine; Uracil | 2023 |
Renal impairment as a risk factor for trifluridine/tipiracil-induced adverse events in metastatic colorectal cancer patients from the REGOTAS study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Colorectal Neoplasms; Drug Combinations; Frontotemporal Dementia; Humans; Neutropenia; Pyrrolidines; Rectal Neoplasms; Retrospective Studies; Risk Factors; Thymine; Trifluridine; Uracil | 2023 |