thymine and o-(6)-methylguanine

thymine has been researched along with o-(6)-methylguanine in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199012 (30.77)18.7374
1990's19 (48.72)18.2507
2000's6 (15.38)29.6817
2010's2 (5.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Day, RS2
Dosanjh, MK; Galeros, G; Goodman, MF; Singer, B1
Dosanjh, MK; Essigmann, JM; Samson, L; Sassanfar, M1
Anderson, MW; Belinsky, SA; Devereux, TR1
Essigmann, JM; Singer, B1
Basu, AK; Benasutti, M; Essigmann, JM; Green, CL; Loechler, EL1
Martel-Planche, G; Mironov, NM; Montesano, R; Swann, PF; Wild, CP1
Basu, AK; Essigmann, JM; Loechler, EL1
Cawkwell, L; Georgiadis, P; Margison, GP; Patel, D; Potter, PM; Swann, PF; Wilkinson, MC1
Rajewsky, MF; Samson, L; Thomale, J1
Bromley, M; Fan, CY; Fida, S; O'Connor, PJ; Saffhill, R1
Graves, RJ; Li, BF; Swann, PF1
Boucheron, J; Deal, F; Richardson, FC; Swenberg, JA; Tyeryar, L1
Dolan, ME; Morimoto, K; Pegg, AE; Scicchitano, D2
Kalnik, M; Li, BF; Patel, DJ; Swann, PF1
Dolan, ME; Pegg, AE; Scicchitano, D; Singer, B1
Lindamood, C; Swenberg, JA; Toorchen, D; Topal, MD1
Ihara, K; Kawate, H; Kohda, K; Sakumi, K; Sekiguchi, M1
Huh, N; Kang, H; Konishi, C; Kuroki, T2
Chance, EM; Swann, PF; Tan, HB1
Kleibl, K; Laval, F; Zak, P1
Harris, LC; Margison, GP1
Drummond, JT; Duckett, DR; Lilley, DM; Modrich, P; Murchie, AI; Reardon, JT; Sancar, A1
Altshuler, KB; Essigmann, JM; Hodes, CS1
Levy, DE; Spratt, TE1
Clarke, ND; Paalman, SR; Sung, C1
Hughes, SH; Moschel, RC; Pauly, GT1
Kooistra, R; Lohman, PH; Margison, GP; Pastink, A; Watson, AJ; Zonneveld, JB1
Encell, LP; Loeb, LA1
Day, RS; Dobler, K; Lari, SU; Paterson, MC1
Moschel, RC; Pauly, GT1
Johnson, RE; Prakash, L; Prakash, S; Washington, MT1
Kaina, B; Lips, J1
Haracska, L; Johnson, RE; Prakash, L; Prakash, S1
Kikuchi, Y; Margison, GP; Millington, CL; Takénaka, A; Tsunoda, M; Wilkinson, O; Williams, DM; Zhang, F1
Duncan Lyngdoh, RH; Premila Devi, S; Salam, T1

Reviews

2 review(s) available for thymine and o-(6)-methylguanine

ArticleYear
Site-specific mutagenesis: retrospective and prospective.
    Carcinogenesis, 1991, Volume: 12, Issue:6

    Topics: Animals; DNA; DNA Damage; Guanine; Humans; Mutagenesis; Neoplasms; Thymine

1991
The role of carcinogen DNA adduct structure in the induction of mutations.
    Progress in clinical and biological research, 1990, Volume: 340A

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Base Sequence; DNA; DNA Adducts; DNA Damage; Guanine; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Thymine

1990

Other Studies

37 other study(ies) available for thymine and o-(6)-methylguanine

ArticleYear
Incision at O6-methylguanine:thymine mispairs in DNA by extracts of human cells.
    Biochemistry, 1992, Sep-01, Volume: 31, Issue:34

    Topics: Base Composition; Base Sequence; Binding, Competitive; Colonic Neoplasms; Deoxyribonuclease I; DNA; DNA Repair; Glioma; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Tumor Cells, Cultured

1992
Kinetics of extension of O6-methylguanine paired with cytosine or thymine in defined oligonucleotide sequences.
    Biochemistry, 1991, Dec-10, Volume: 30, Issue:49

    Topics: Base Composition; Base Sequence; Cytosine; DNA-Directed DNA Polymerase; Escherichia coli; Guanine; Kinetics; Molecular Sequence Data; Mutagenesis; Oligonucleotides; Thymine

1991
Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases.
    The Journal of biological chemistry, 1991, Feb-15, Volume: 266, Issue:5

    Topics: Base Sequence; Carcinogens; DNA Damage; DNA Repair; Escherichia coli; Guanine; Humans; Methyltransferases; Molecular Sequence Data; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Thymine

1991
Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.
    Carcinogenesis, 1991, Volume: 12, Issue:2

    Topics: Animals; Base Sequence; Codon; Dimethylnitrosamine; DNA; Drug Resistance; Gene Expression Regulation, Neoplastic; Genes, ras; Guanine; Incidence; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Molecular Sequence Data; Mutation; Nitrosamines; Proto-Oncogenes; Thymine; Time Factors

1991
Measurement of the removal of O6-methylguanine and O4-methylthymine from oligodeoxynucleotides using an immunoprecipitation technique.
    Analytical biochemistry, 1989, Nov-15, Volume: 183, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Base Sequence; Chromatography, High Pressure Liquid; Guanine; Humans; Male; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Precipitin Tests; Rats; Thymine

1989
Mutagenic specificity of alkylated and oxidized DNA bases as determined by site-specific mutagenesis.
    Annali dell'Istituto superiore di sanita, 1989, Volume: 25, Issue:1

    Topics: DNA Mutational Analysis; DNA, Bacterial; Escherichia coli; Guanine; Mutation; Thymine

1989
Purification of the E. coli ogt gene product to homogeneity and its rate of action on O6-methylguanine, O6-ethylguanine and O4-methylthymine in dodecadeoxyribonucleotides.
    Nucleic acids research, 1989, Nov-11, Volume: 17, Issue:21

    Topics: Alkylating Agents; Amino Acids; Chromatography, High Pressure Liquid; Deoxyribonucleotides; DNA Repair; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; Genes, Bacterial; Guanine; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine

1989
Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.
    The EMBO journal, 1988, Volume: 7, Issue:7

    Topics: Alkylation; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Kinetics; Methylnitrosourea; Mutation; Thymine

1988
Phenobarbital: a non-genotoxic agent which induces the repair of O6-methylguanine from hepatic DNA.
    Carcinogenesis, 1988, Volume: 9, Issue:11

    Topics: 2-Acetylaminofluorene; Animals; DNA Repair; Guanine; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenobarbital; Rats; Thymine

1988
Repair of synthetic oligonucleotides containing O6-methylguanine, O6-ethylguanine and O4-methylthymine, by O6-alkylguanine-DNA alkyltransferase.
    IARC scientific publications, 1987, Issue:84

    Topics: Animals; Chromatography, High Pressure Liquid; DNA Repair; Escherichia coli; Guanine; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine

1987
The molecular dosimetry of DNA adducts formed by continuous exposure of rats to alkylating hepatocarcinogens.
    Progress in experimental tumor research, 1987, Volume: 31

    Topics: 1,2-Dimethylhydrazine; Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Dimethylhydrazines; DNA Damage; Guanine; Liver; Rats; Thymine

1987
Specificity of O6-alkylguanine-DNA alkyltransferase.
    IARC scientific publications, 1987, Issue:84

    Topics: Alkylation; Animals; Cattle; DNA Repair; Guanine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; RNA, Ribosomal; RNA, Transfer; Substrate Specificity; Thymine

1987
Synthesis and structural studies by nuclear magnetic resonance of dodecadeoxynucleotides containing O6-methylguanine, O6-ethylguanine and O4-methylthymine.
    IARC scientific publications, 1987, Issue:84

    Topics: Guanine; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Thymine

1987
Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.
    Environmental health perspectives, 1985, Volume: 62

    Topics: Animals; Cell Line; DNA; DNA Repair; Escherichia coli; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Organ Specificity; Rats; Species Specificity; Substrate Specificity; Thymine

1985
Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli.
    Biochemical and biophysical research communications, 1984, Aug-30, Volume: 123, Issue:1

    Topics: Animals; DNA Repair; Escherichia coli; Guanine; Liver; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Poly T; Polydeoxyribonucleotides; Rats; Thymine

1984
O6-Methylguanine-DNA transmethylase converts O6-methylguanine thymine base pairs to guanine thymine base pairs in DNA.
    Carcinogenesis, 1984, Volume: 5, Issue:12

    Topics: Base Composition; DNA Repair; Guanine; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Thymine

1984
Mouse methyltransferase for repair of O6-methylguanine and O4-methylthymine in DNA.
    Carcinogenesis, 1995, Volume: 16, Issue:7

    Topics: 3T3 Cells; Animals; Base Sequence; DNA Repair; DNA, Complementary; Guanine; HeLa Cells; Humans; Immunoblotting; Intracellular Fluid; Methylnitronitrosoguanidine; Methyltransferases; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity; Thymine

1995
Site specificity of incisions at G:T and O6-methylguanine:T base mismatches in DNA by human cell-free extracts.
    Biochemistry, 1995, May-23, Volume: 34, Issue:20

    Topics: Base Composition; Base Sequence; Binding Sites; Binding, Competitive; Cell-Free System; DNA; Guanine; Humans; Molecular Sequence Data; Thymine; Tumor Cells, Cultured

1995
Detection of O6-methylguanine, O4-methylthymine and O4-ethylthymine in human liver and peripheral blood leukocyte DNA.
    Carcinogenesis, 1995, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Aged; Autopsy; DNA; DNA Adducts; Female; Guanine; Humans; Leukocytes; Liver; Male; Middle Aged; Thymine

1995
Kinetic analysis of the coding properties of O6-methylguanine in DNA: the crucial role of the conformation of the phosphodiester bond.
    Biochemistry, 1994, May-03, Volume: 33, Issue:17

    Topics: Base Sequence; Cytosine; DNA; DNA Primers; Exodeoxyribonuclease V; Exodeoxyribonucleases; Guanine; Kinetics; Mathematics; Models, Theoretical; Molecular Sequence Data; Nucleic Acid Conformation; Templates, Genetic; Thymine

1994
Repair of O6-methylguanine and O4-methylthymine by the human and rat O6-methylguanine-DNA methyltransferases.
    The Journal of biological chemistry, 1994, Jan-07, Volume: 269, Issue:1

    Topics: Animals; DNA; DNA Repair; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; Kinetics; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Thymine

1994
A highly sensitive and specific method for quantitation of O-alkylated DNA adducts and its application to the analysis of human tissue DNA.
    Environmental health perspectives, 1993, Volume: 99

    Topics: Alkylating Agents; Alkylation; Chromatography, High Pressure Liquid; DNA; DNA Damage; Guanine; Humans; Leukocytes; Phosphorus Radioisotopes; Precipitin Tests; Sensitivity and Specificity; Thymine

1993
Expression in mammalian cells of the Escherichia coli O6 alkylguanine-DNA-alkyltransferase gene ogt reduces the toxicity of alkylnitrosoureas.
    British journal of cancer, 1993, Volume: 67, Issue:6

    Topics: Animals; Bacterial Proteins; Base Sequence; Cell Survival; Clone Cells; Cricetinae; Drug Resistance; Escherichia coli; Fibroblasts; Gene Expression; Guanine; Lung; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Transfection

1993
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Jun-25, Volume: 93, Issue:13

    Topics: Adenosine Triphosphatases; Bacterial Proteins; Base Composition; Base Sequence; Cisplatin; Dinucleoside Phosphates; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Escherichia coli Proteins; Guanine; Humans; Molecular Sequence Data; MutS DNA Mismatch-Binding Protein; Protein Binding; Thymine

1996
Intrachromosomal probes for mutagenesis by alkylated DNA bases replicated in mammalian cells: a comparison of the mutagenicities of O4-methylthymine and O6-methylguanine in cells with different DNA repair backgrounds.
    Chemical research in toxicology, 1996, Volume: 9, Issue:6

    Topics: Animals; CHO Cells; Cricetinae; DNA; DNA Repair; Genetic Markers; Genetic Vectors; Guanine; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Sequence Analysis; Thymine; Transfection

1996
Structure of the hydrogen bonding complex of O6-methylguanine with cytosine and thymine during DNA replication.
    Nucleic acids research, 1997, Aug-15, Volume: 25, Issue:16

    Topics: Cytosine; DNA Replication; Guanine; Hydrogen Bonding; Hydrogen-Ion Concentration; Structure-Activity Relationship; Thymine

1997
Specificity of DNA repair methyltransferases determined by competitive inactivation with oligonucleotide substrates: evidence that Escherichia coli Ada repairs O6-methylguanine and O4-methylthymine with similar efficiency.
    Biochemistry, 1997, Sep-16, Volume: 36, Issue:37

    Topics: Bacterial Proteins; Binding, Competitive; Cloning, Molecular; DNA Repair; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Gene Expression; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Peptide Fragments; Thymine; Transcription Factors

1997
Comparison of mutagenesis by O6-methyl- and O6-ethylguanine and O4-methylthymine in Escherichia coli using double-stranded and gapped plasmids.
    Carcinogenesis, 1998, Volume: 19, Issue:3

    Topics: DNA Methylation; DNA Repair; Escherichia coli; Guanine; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Thymine

1998
Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA.
    Nucleic acids research, 1999, Apr-15, Volume: 27, Issue:8

    Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA Repair; DNA, Complementary; Drosophila melanogaster; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Guanine; Humans; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thymine; Transcription Factors

1999
Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase.
    Carcinogenesis, 2000, Volume: 21, Issue:7

    Topics: DNA Damage; DNA Repair; Enzyme Inhibitors; Escherichia coli; Guanine; Humans; Lac Operon; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Point Mutation; Substrate Specificity; Thymine

2000
Initiation of strand incision at G:T and O(6)-methylguanine:T base mismatches in DNA by human cell extracts.
    Nucleic acids research, 2001, Jun-01, Volume: 29, Issue:11

    Topics: Adenosine Triphosphate; Base Pair Mismatch; Base Sequence; Cell Extracts; Cell-Free System; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Repair; Dose-Response Relationship, Drug; Endodeoxyribonucleases; Guanine; HT29 Cells; Humans; Mutation; Nucleotides; Substrate Specificity; Thymine; Tumor Cells, Cultured

2001
Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair.
    Chemical research in toxicology, 2001, Volume: 14, Issue:7

    Topics: Base Pair Mismatch; Colonic Neoplasms; Escherichia coli; Genetic Vectors; Guanine; Humans; Kidney; Lac Operon; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Transfection

2001
Accuracy of lesion bypass by yeast and human DNA polymerase eta.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Jul-17, Volume: 98, Issue:15

    Topics: DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Humans; Ligases; Saccharomyces cerevisiae; Thymine; Ubiquitin-Conjugating Enzymes; Ultraviolet Rays

2001
Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins.
    Mutation research, 2001, Nov-01, Volume: 487, Issue:1-2

    Topics: Animals; Base Pair Mismatch; Cell Survival; CHO Cells; Cricetinae; DNA Repair; Guanine; O(6)-Methylguanine-DNA Methyltransferase; Thymine

2001
Role of hoogsteen edge hydrogen bonding at template purines in nucleotide incorporation by human DNA polymerase iota.
    Molecular and cellular biology, 2006, Volume: 26, Issue:17

    Topics: Base Pairing; Cytosine; DNA Damage; DNA Polymerase iota; DNA Primers; DNA-Directed DNA Polymerase; Guanine; Humans; Hydrogen Bonding; Kinetics; Purines; Templates, Genetic; Thymine

2006
O⁶-carboxymethylguanine in DNA forms a sequence context-dependent wobble base-pair structure with thymine.
    Acta crystallographica. Section D, Biological crystallography, 2014, Volume: 70, Issue:Pt 6

    Topics: Base Pairing; Crystallization; Crystallography, X-Ray; DNA; Guanine; Thymine

2014
Molecular criteria for mutagenesis by DNA methylation: Some computational elucidations.
    Mutation research, 2018, Volume: 807

    Topics: Alkylating Agents; Base Pairing; Computational Biology; DNA; DNA Methylation; Guanine; Nucleic Acid Conformation; Thymine

2018