thymine has been researched along with fluorouracil in 129 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 74 (57.36) | 18.7374 |
| 1990's | 12 (9.30) | 18.2507 |
| 2000's | 16 (12.40) | 29.6817 |
| 2010's | 15 (11.63) | 24.3611 |
| 2020's | 12 (9.30) | 2.80 |
| Authors | Studies |
|---|---|
| Hall, IH; Lee, KH; Wu, YS | 1 |
| Aryasomayajula, R; Bandi, PR; Jennepalli, S; Kura, RR; Musku, MR; Rondla, SR; Vedula, MS | 1 |
| Forsthoefel, PF; Williams, ML | 1 |
| Johnson, GA | 1 |
| Heinonen, J; Kukko, E | 1 |
| Friedman, MA; Sadée, W | 1 |
| Bloch, A; Bobek, M; Kuhar, S | 1 |
| Kaneko, M; Kikugawa, M; Kontani, Y; Tamaki, N | 1 |
| Hatta, H; Kagiya, T; Nishimoto, S; Ueshima, H | 1 |
| Darland, G; Kaplan, L; Rosenbach, M | 1 |
| Kiang, DT; Mirkin, BL; O'Dea, RF; Ramnaraine, ML; Stoeckeler, JS; Tuchman, M | 1 |
| Fujii, S; Fukushima, M; Shirasaka, T; Tatsumi, K | 1 |
| Bronk, JR; Lister, N; Lynch, S | 1 |
| O'Dea, RF; Ramnaraine, ML; Tuchman, M | 2 |
| Balzarini, J; Bricaud, H; De Clercq, E; Desgranges, C; Drouillet, F; Herdewijn, P; Razaka, G | 1 |
| Cano, JP; Cross, DS; Diasio, RB; Gewirtz, DA; Goldman, ID; Sommadossi, JP | 2 |
| Killion, K; Rao, KV; Tanrikut, Y | 1 |
| Bresler, SK; Mosevitskii, MI; Vyacheslavov, LG | 1 |
| Houlihan, RB; Roby, R; Teskey, C | 1 |
| Borek, E; Ryan, A | 1 |
| Heidelberger, C | 2 |
| Wolberg, WH | 3 |
| Agarwal, DP; Eickhoff, K; Goedde, HW | 1 |
| Geller, M; Kulakowska, I; Lesyng, B; Wierzchowski, KL | 1 |
| Bisaillon, JG; De Repentigny, J; Mathieu, LG | 1 |
| Boyle, JM | 1 |
| Friedkin, M | 1 |
| Brozmanová, J; Sedliaková, M | 1 |
| Heidelberger, C; Khwaja, T; Meyer, RB; Miyazaki, T; Nesnow, S | 1 |
| Bärwolff, D; Langen, P; Matthes, E | 1 |
| Brozmanová, J; Sedliaková, M; Varkonda, S | 1 |
| Donch, J; Green, MH; Greenberg, J | 1 |
| Cohen, SS | 1 |
| Archer, LJ; Landman, OE | 1 |
| Reich, J; Soska, J | 1 |
| Antonovskiĭ, VL; Gukovskaia, AS; Prokop'eva, TM; Sukhoroukov, BI | 1 |
| Fischer, HU; Jobski, C; Mundinger, F; Ostertag, C; Vogt, P | 1 |
| Cooper, GM; Dunning, WF; Greer, S | 1 |
| Dorsett, MT; Gentry, GA; Morse, PA | 1 |
| Cernohorský, IJ; Miller, V; Pacáková, V | 1 |
| Andoh, T; Chargaff, E | 1 |
| Barner, HD; Cohen, SS; Stern, JL | 1 |
| Horiuchi, T; Ohshima, Y | 1 |
| Lark, C; Lark, KG | 2 |
| Ebner, H | 1 |
| Greenberg, DM; Reeves, WJ; Seid, A | 1 |
| Reynolds, VH; Van Way, CW | 1 |
| Jordan, RL; Schumacher, H; Wilson, JG | 1 |
| Jordan, RL; Schumacher, HJ; Wilson, JG | 1 |
| Lallier, R | 1 |
| Green, WR; Lis, AW | 1 |
| Au, JL; Creaven, PJ; Ledesma, EJ; Mittelman, A; Rustum, YM | 1 |
| Fujii, S; Shirasaka, T | 1 |
| Burchenal, D; Clarkson, BD; Fried, J; Murgo, AJ; Strife, A; Vale, KL; Woodcock, T; Young, CW | 1 |
| Fujii, S; Fukushima, M; Ikenaka, K; Kitano, S; Maehara, Y; Nakamura, H; Shirasaka, T | 1 |
| Marunaka, T; Umeno, Y | 1 |
| Covey, JM; Straw, JA | 1 |
| Holland, JF; Mandel, E; Martin, DS; Ohnuma, T; Roboz, J; Waxman, S | 1 |
| Fernandez-Salguero, P; Furuya, H; Gonzalez, FJ; Lin, K; McBride, OW; Podschun, B; Schnackerz, KD; Yokota, H | 1 |
| Baptiste, N; O'Connor, CJ; Otter, BA; Schwartz, EL; Wadler, S | 1 |
| Azuma, A; Hanaoka, K; Kobayashi, T; Matsuda, A; Minakawa, N; Nakajima, Y; Nishizono, N; Sasaki, T; Suzuki, M; Tanaka, M | 1 |
| Courtney, A; Cox, J; Meyer, W; Mues, G; Nemunaitis, J | 1 |
| Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Akamo, Y; Fukui, T; Kidouchi, K; Kobayashi, K; Manabe, T; Mizuno, I; Mohri, N; Sumi, S; Takeyama, H | 1 |
| Hamajima, N; Imaeda, M; Kidouchi, K; Kodama, K; Ohba, S; Sumi, S; Togari, H; Wada, Y | 1 |
| Elizondo, G; Fernandez-Salguero, P; Gonzalez, FJ; McLeod, HL; Raunio, H; Sapone, A; Wei, X | 1 |
| Harwood, FG; Houghton, JA; Tillman, DM | 1 |
| Dobashi, K; Hayashi, K; Kidouchi, K; Kondou, M; Kouwaki, M; Sumi, S; Togari, H; Wada, Y | 1 |
| Gierens, H; März, W; Nauck, M; Wieland, H | 1 |
| Baas, F; Haasjes, J; Meinsma, R; Muller, EW; Richel, DJ; van Gennip, AH; van Kuilenburg, AB; Waterham, HR; Zoetekouw, L | 1 |
| Aukett, A; Baaske, H; Dobritzsch, D; Duley, JA; Haasjes, J; Hein, G; Kalhoff, H; Kirk, JM; Lindqvist, Y; Maropoulos, GD; Meinsma, R; Nowaczyk, MJ; van Gennip, AH; van Kuilenburg, AB; Ward, KP; Waterham, HR | 1 |
| Fukushima, M; Honda, T; Inagawa, H; Moriyama, A; Soma, G | 1 |
| BIRNIE, GD; HEIDELBERGER, C | 1 |
| GOTTSCHLING, H; HEIDELBERGER, C | 1 |
| GALLANT, J; STAPLETON, R | 1 |
| BOND, SB; KRISS, JP | 1 |
| DEREPENTIGNY, J; FRAPPIER, A; SONEA, S | 1 |
| GEISSLER, E | 1 |
| BIRNIE, GD; BOOHAR, J; HEIDELBERGER, C | 1 |
| LANGEN, P | 1 |
| BODMER, WF; GRETHER, S | 1 |
| MORSE, PA; POTTER, VR | 1 |
| ROSENTHAL, HA | 1 |
| BASCH, RS; KARNOFSKY, DA | 1 |
| JACQUEZ, JA | 1 |
| Abeling, NG; Stroomer, AE; Van Gennip, AH; Van Kuilenburg, AB; Van Lenthe, H | 1 |
| Croxford, R; Kim, YI; Lucock, M; Sohn, KJ; Yates, Z | 1 |
| Emura, T; Fukushima, M; Kitazato, K; Murakami, Y; Nakagawa, F | 1 |
| Emura, T; Fukushima, M; Ohshimo, H; Suzuki, N; Yamaguchi, M | 1 |
| Abdul-Jabbar, MA; Al-Sanna'a, NA; Atrak, TM; Van Gennip, AH; Van Kuilenburg, AB | 1 |
| Al-Salabi, MI; Candlish, D; de Koning, HP; Gudin, S; Jarvis, SM; Quashie, NB; Ranford-Cartwright, LC | 1 |
| Billinghurst, BE; Loppnow, GR; Yeung, R | 1 |
| Dai, HX; Wang, J; Yao, SP | 1 |
| Boisdron-Celle, M; Fey, L; Gamelin, E; Lainé-Cessac, P; Morel, A | 1 |
| Peters, GJ; Prins, HJ; Temmink, OH; van Gelderop, E | 1 |
| Agelis, G; Botić, T; Cencic, A; Dolinsek, J; Komiotis, D; Tsoukala, E | 1 |
| Cabezas-Herrera, J; Campo, LS; Navarro-Perán, E; Rodríguez-López, JN | 1 |
| Balzarini, J; Kiritsis, C; Komiotis, D; Manta, S; Tsoukala, E; Tzioumaki, N | 2 |
| Taketsugu, T; Yamazaki, S | 1 |
| Balzarini, J; Dimopoulou, A; Kiritsis, C; Kollatos, N; Komiotis, D; Manta, S; Papasotiriou, I; Parmenopoulou, V | 1 |
| Nakagawa, F; Nukatsuka, M; Saito, H; Sakata, M; Takechi, T; Uchida, J | 1 |
| Ishida, K; Kazuno, H; Matsuo, K; Oguchi, K; Okabe, H; Osada, A; Sakamoto, K; Tanaka, N; Ueno, H; Yamada, Y; Yokogawa, T | 1 |
| Cameron, A; Charles, BG; Duley, JA; George, R; Harris, M; Helsby, N; Mead, S; Ni, M; Norris, RL; Shannon, C; Sheffield, L; van Kuilenburg, AB | 1 |
| Hochster, HS; Uboha, N | 1 |
| Alonso-Orduña, V; Capdevila, J; Hernando-Cubero, J; Matos-García, I | 1 |
| Aglietta, M; Bonzano, A; Cagnazzo, C; Depetris, I; Filippi, R; Leone, F; Marino, D | 1 |
| Cervantes, A; Moreno Vera, S; Peeters, M; Taieb, J | 1 |
| Charles, BG; Cowley, D; Duley, JA; George, R; Harris, M; Helsby, N; Ni, M; Norris, RL; Shannon, C; Sheffield, L; van Kuilenburg, ABP | 1 |
| Milano, G | 1 |
| Banchi, M; Bocci, G; Cremolini, C; Cucchiara, F; Di Desidero, T; Falcone, A; Gentile, D; Moretto, R; Orlandi, P | 1 |
| Asai, A; Doki, Y; Haraguchi, N; Ishii, H; Kobunai, T; Konno, M; Koseki, J; Matsuoka, K; Mori, M; Takechi, T; Tsunekuni, K | 1 |
| Barlow, P; Bonnet, C; Brenman, E; Burns, KE; Duley, J; Findlay, M; Helsby, NA; Jeong, SH; Porter, D; Sharples, K | 1 |
| Carter, AM; Iveson, T; Mullamitha, S; Shiu, KK; Spooner, C; Stevens, D | 1 |
| Amellal, N; Argilés, G; Aubel, P; Borg, C; Danielewicz, I; Egorov, A; Falcone, A; Fedyanin, M; Garcia-Alfonso, P; Glynne-Jones, R; Kanehisa, A; Kroening, H; Moiseenko, V; Pfeiffer, P; Punt, CJA; Saunders, MP; Stroyakovskiy, D; Van Cutsem, E; Van de Wouw, AJ; Wasan, H | 1 |
| Antonuzzo, L; Castiglione, F; Di Costanzo, F; Lastraioli, E; Lavacchi, D; Messerini, L; Palmieri, VE | 1 |
| Fukazawa, A; Hasegawa, S; Ishibashi, K; Ishida, H; Kamiyama, H; Koda, K; Kosugi, C; Kuramochi, H; Matsuda, A; Otsuka, T; Sakamoto, K; Sonoda, H; Yamada, T; Yamaguchi, S; Yoshida, H; Yoshida, Y; Yoshimatsu, K | 1 |
| Akamatsu, H; Asaoka, T; Furukawa, K; Imasato, M; Inui, M; Iwamoto, K; Kishi, K; Mikamori, M; Moon, J; Naito, A; Nakahara, Y; Ohtsuka, M; Wada, R; Zenitani, S | 1 |
| Fukada, M; Futamura, M; Imai, H; Imai, T; Iwata, Y; Matsuhashi, N; Mori, R; Okumura, N; Sato, Y; Suetsugu, T; Takahashi, T; Tanaka, H; Tanaka, Y; Yasufuku, I; Yoshida, K | 1 |
| Delaney, S; Tarantino, ME | 1 |
| Dechow, T; Ettrich, TJ; Fruehauf, S; Fuchs, M; Heinemann, V; Hoyer, I; Kaiser, F; Karthaus, M; Kiani, A; König, A; Kurreck, A; Modest, DP; Müller, L; Quante, M; Reinacher-Schick, A; Roderburg, C; Schwaner, I; Sommerhäuser, G; Stahler, A; Stintzing, S; von Weikersthal, LF | 1 |
| Broeren, MAC; Brunsveld, L; Deenen, MJ; Hanrath, MA; Lapré, C; Scharnhorst, V; Streng, AS; van de Kerkhof, D; van den Broek, R; van den Wildenberg, SAH; van Dongen, JLJ | 1 |
| Chang, I; Chang, WJ; Chen, R; Circelli, J; Harpel, Z; Rivera, J; Wei, R; Wu, S | 1 |
9 review(s) available for thymine and fluorouracil
| Article | Year |
|---|---|
The fluoropyrimidines: biochemical mechanisms and design of clinical trials.
Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Metabolism; Methotrexate; Pyrimidines; Thymidine; Thymine | 1978 |
Lysogenic induction.
Topics: Animals; Bacteria; Bacteriolysis; Bacteriophages; Cell Transformation, Neoplastic; Chromosomes; Coliphages; Conjugation, Genetic; Crosses, Genetic; DNA, Bacterial; DNA, Viral; Escherichia coli; Floxuridine; Fluorouracil; Genes; Lysogeny; Mitomycins; Mutation; Thymine; Transcription, Genetic; Ultraviolet Rays; Virus Replication | 1973 |
Thymidylate synthetase.
Topics: Animals; Binding Sites; Deoxyuridine; Drug Stability; Escherichia coli; Fluorouracil; Folic Acid Deficiency; Genes, Regulator; Hot Temperature; Hydrogen; Kinetics; Methyltransferases; Mutation; Neoplasms; Protein Binding; Protein Conformation; Salmonella typhimurium; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfhydryl Compounds; Tetrahydrofolates; Thymidylate Synthase; Thymine | 1973 |
Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture.
Topics: Animals; Antineoplastic Agents; Arginase; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Deoxyribonucleases; DNA; Fluorouracil; Humans; Liver Neoplasms; Methylcholanthrene; Mice; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Oncogenic Viruses; Orotic Acid; Phenanthrenes; Protein Binding; Pyrimidinones; Rats; Skin Neoplasms; Thymine; Uracil | 1970 |
On the nature of thymineless death.
Topics: Antineoplastic Agents; Coliphages; Deoxyribonucleosides; DNA Replication; DNA, Bacterial; Escherichia coli; Fluorouracil; HeLa Cells; Nucleic Acid Denaturation; RNA, Bacterial; Sulfanilamides; Thymine | 1971 |
TAS-102: a novel antimetabolite for the 21st century.
Topics: Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Clinical Trials as Topic; Colorectal Neoplasms; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Humans; Neoplasms; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; Uracil | 2016 |
The Role of Fluoropirimidines in Gastrointestinal Tumours: from the Bench to the Bed.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Resistance, Neoplasm; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Gastrointestinal Neoplasms; Humans; Molecular Targeted Therapy; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Pyrrolidines; Thymidine Phosphorylase; Thymidylate Synthase; Thymine; Trifluridine; Uracil | 2017 |
Fluoropyrimidine-induced cardiotoxicity.
Topics: Acetates; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyrimidines; Pyrrolidines; Quinazolines; Thiophenes; Thymine; Trifluridine; Uracil; Uridine | 2018 |
Trifluridine/tipiracil: an emerging strategy for the management of gastrointestinal cancers.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Clinical Trials as Topic; Colonic Neoplasms; Docetaxel; Drug Combinations; Fluorouracil; Gastrointestinal Neoplasms; Humans; Immunotherapy; Indoles; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Pyrrolidines; Quality of Life; Taxoids; Thymine; Trifluridine; Uracil | 2018 |
4 trial(s) available for thymine and fluorouracil
| Article | Year |
|---|---|
Towards a test to predict 5-fluorouracil toxicity: Pharmacokinetic data for thymine and two sequential metabolites following oral thymine administration to healthy adult males.
Topics: Adult; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Male; Middle Aged; Models, Biological; Saliva; Thymine; Urea | 2016 |
Trifluridine/tipiracil plus bevacizumab in patients with untreated metastatic colorectal cancer ineligible for intensive therapy: the randomized TASCO1 study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Fluorouracil; Humans; Pyrrolidines; Quality of Life; Thymine; Trifluridine | 2020 |
Combination of TAS-102 and bevacizumab as third-line treatment for metastatic colorectal cancer: TAS-CC3 study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Disease-Free Survival; Drug Combinations; Fluorouracil; Humans; Japan; Leucovorin; Pyrrolidines; Thymine; Trifluridine | 2021 |
Study protocol of the FIRE-8 (AIO-KRK/YMO-0519) trial: a prospective, randomized, open-label, multicenter phase II trial investigating the efficacy of trifluridine/tipiracil plus panitumumab versus trifluridine/tipiracil plus bevacizumab as first-line tre
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Body Weight; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Fluorouracil; Humans; Multicenter Studies as Topic; Panitumumab; Prospective Studies; Pyrrolidines; Randomized Controlled Trials as Topic; Thymine; Trifluridine | 2022 |
116 other study(ies) available for thymine and fluorouracil
| Article | Year |
|---|---|
Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine alpha-methylene-gamma-lactones and related derivatives.
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Lactones; Leukemia, Experimental; Male; Melanoma; Mice; Neoplasms, Experimental; Rats; Thymine; Uracil | 1977 |
Novel nucleosides as potent influenza viral inhibitors.
Topics: Animals; Antiviral Agents; Cell Line; Dogs; Humans; Influenza A virus; Influenza B virus; Influenza, Human; Purine Nucleosides; Pyrimidine Nucleosides; Structure-Activity Relationship | 2010 |
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cell Survival; Drug Synergism; Female; Fetal Death; Floxuridine; Fluorouracil; Forelimb; Genes; Hindlimb; Mice; Mutation; Nucleic Acids; Pregnancy; Protein Precursors; Thymidine; Thymine; Tibia; Toes; Uracil | 1975 |
Free radicals formed by exposure of pyrimidine solids to sodium atoms: an electron spin resonance study.
Topics: Alloxan; Bromouracil; Cytosine; Electron Spin Resonance Spectroscopy; Fluorouracil; Free Radicals; Pyrimidines; Sodium; Thymine; Uracil | 1975 |
Partial inhibition of DNA synthesis gives rise to increase in the level of inorganic pyrophosphatase in the growing cells of Escherichia coli.
Topics: Depression, Chemical; DNA, Bacterial; Escherichia coli; Fluorouracil; Mitomycins; Nalidixic Acid; Pyrophosphatases; Thymine; Trimethoprim | 1977 |
Synthesis and biological activity of 5-fluoro- and 5-methyl-1,3-oxazine-2,6(3H)-dione.
Topics: Animals; Cell Division; Culture Media; Drug Stability; Escherichia coli; Fluorouracil; In Vitro Techniques; Leukemia L1210; Mice; Oxazines; Pyrimidines; Spectrophotometry, Ultraviolet; Streptococcus; Thymine | 1979 |
Inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by 5-fluorouracil and alpha-fluoro-beta-alanine.
Topics: Alanine Transaminase; Animals; beta-Alanine; Fluorouracil; Kinetics; Liver; Rats; Thymine; Transaminases | 1992 |
1-(5'-Fluoro-6'-hydroxy-5',6'-dihydrouracil-5'-yl)-5-fluorouracil, a novel N(1)-C(5)-linked dimer that releases 5-fluorouracil by radiation activation under hypoxic conditions.
Topics: Animals; Antineoplastic Agents; Electrochemistry; Female; Fluorouracil; Mice; Mice, Inbred C3H; Prodrugs; Thymine | 1992 |
Isolation of a thymidine kinase negative mutant of Nocardia lactamdurans.
Topics: DNA, Bacterial; Floxuridine; Fluorouracil; Mutation; Nocardia; Phenotype; Thymidine; Thymidine Kinase; Thymine | 1989 |
Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity.
Topics: Adult; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; Fluorouracil; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Thymine; Uracil | 1985 |
Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.
Topics: Animals; Barbiturates; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NAD+); Fluorouracil; Kinetics; Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Pyridines; Pyrimidines; Rats; Sarcoma 180; Thymine; Uracil | 1987 |
Absorption of 5-fluorouracil and related pyrimidines in rat small intestine.
Topics: Animals; Biological Transport, Active; Chromatography, High Pressure Liquid; Fluorouracil; Galactose; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Perfusion; Rats; Rats, Inbred Strains; Thymine; Uracil; Water | 1987 |
In vitro degradation of pyrimidine bases: studies of rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1986 |
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.
Topics: Animals; Bromouracil; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Fluorouracil; Leukemia P388; Leukemia, Experimental; Liver; Metabolic Clearance Rate; Mice; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil | 1986 |
Modulation of 5-fluorouracil catabolism in isolated rat hepatocytes with enhancement of 5-fluorouracil glucuronide formation.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Fluorouracil; In Vitro Techniques; Kinetics; Liver; Male; Pyrimidine Nucleosides; Rats; Rats, Inbred Strains; Thymine; Tritium; Uracil | 1985 |
Evidence from rat hepatocytes of an unrecognized pathway of 5-fluorouracil metabolism with the formation of a glucuronide derivative.
Topics: Animals; Cell Membrane Permeability; Fluorouracil; Glucuronates; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Thymine; Time Factors; Tritium | 1985 |
Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Rats; Rats, Inbred Strains; Thymidine; Thymine; Uracil; Uridine | 1985 |
GLC determination of fluorouracil.
Topics: Aniline Compounds; Bacillus subtilis; Biological Assay; Chromatography, Gas; Chromatography, Ion Exchange; Escherichia coli; Fluorouracil; Methods; Spectrophotometry, Ultraviolet; Thymine; Uracil | 1974 |
Errors in DNA replication in bacteria in the presence of a thymidylic acid deficiency.
Topics: Bacillus subtilis; Bromouracil; Cell Survival; Deoxyribonucleosides; DNA Replication; Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Glucose; Kinetics; Mathematics; Methyltransferases; Mutagens; Mutation; Probability; Species Specificity; Streptomycin; Thymidine; Thymidylate Synthase; Thymine; Time Factors; Tryptophan | 1974 |
Inhibition of plaque formation by myxoma and fibroma viruses with pyrimidine analogues.
Topics: Antiviral Agents; Benzimidazoles; Bromodeoxyuridine; Culture Techniques; Cytosine; DNA, Viral; Fibroma; Floxuridine; Fluorouracil; Idoxuridine; Mercaptopurine; Methotrexate; Myxoma virus; Nucleosides; Oncogenic Viruses; Thiosemicarbazones; Thymine | 1965 |
The nucleotides of fluorinated pyrimidines and their biological activities.
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Ion Exchange; Floxuridine; Fluorine; Fluorouracil; Formates; HeLa Cells; Kinetics; Mice; Models, Biological; Pyrimidine Nucleotides; Pyrimidines; RNA; Structure-Activity Relationship; Thymidylate Synthase; Thymine; Vaccinia virus | 1971 |
Considerations in the development of a predictive system for cancer chemotherapy.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; DNA; Floxuridine; Fluorouracil; Liver Neoplasms; Neoplasms, Experimental; Nucleosides; Thymine | 1971 |
A note on in vitro inhibition of thymine degradation by some pyrimidine analogues and related products.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Depression, Chemical; Fluorouracil; In Vitro Techniques; Liver; Pyrimidines; Swine; Thymine; Uracil | 1969 |
Dipole moments of 2,4-diketopyrimidines. II. Uracil, thymine and their derivatives.
Topics: Chemical Phenomena; Chemistry, Physical; Chlorine; Dioxanes; Ethyl Ethers; Evaluation Studies as Topic; Fluorouracil; Isomerism; Light; Mathematics; Nitro Compounds; Optics and Photonics; Pyrimidines; Pyrimidinones; Spectrophotometry, Infrared; Thymine; Uracil | 1974 |
Influence of cell wall inhibitors in thymine-requiring Staphylococcus aureus strains.
Topics: Alanine; Cell Wall; Cycloserine; DNA, Bacterial; Fluorouracil; Methicillin; Mucoproteins; Penicillin Resistance; Penicillins; Staphylococcus; Thymine | 1972 |
Genetic and physiological factors relating to excision-repair in Escherichia coli.
Topics: Cell Survival; Coliphages; Deoxyribonucleases; DNA Nucleotidyltransferases; DNA Repair; DNA, Bacterial; DNA, Viral; Escherichia coli; Fluorouracil; Molecular Weight; Mutation; Nucleic Acid Denaturation; Pyrimidines; Radiation Effects; Thymidine; Thymine; Time Factors; Tritium; Ultraviolet Rays | 1972 |
Thymine dimer excision in UV-irradiated and 5-fluorouracil-postincubated Escherichia coli.
Topics: Carbon Radioisotopes; Cell Count; Cell Survival; DNA Repair; DNA, Bacterial; Escherichia coli; Fluorouracil; Histidine; Mutation; Radiation Effects; Thymine; Ultraviolet Rays; Uracil | 1974 |
Pyridine nucleosides related to 5-fluorouracil and thymine.
Topics: Cell Line; Chromatography, Thin Layer; Circular Dichroism; Dealkylation; Fluorouracil; Growth; Humans; Magnetic Resonance Spectroscopy; Methods; Molecular Conformation; Nucleosides; Pyridines; Pyridones; Spectrophotometry, Ultraviolet; Thymine | 1973 |
Inhibition by 6-aminothymine of the degradation of nucleosides (5-iododeoxyuridine, thymidine) and pyrimidine bases (5-iodouracil, uracil and 5-fluorouracil) in vivo.
Topics: Amines; Animals; Antimetabolites; Bone Marrow; Chromatography; DNA; Fluorouracil; Idoxuridine; Intestinal Mucosa; Iodine Radioisotopes; Male; Mice; Nucleosides; Pentosyltransferases; Rabbits; Spleen; Thymidine; Thymine; Thymus Gland; Uracil | 1974 |
Effect of 5-fluorouracil post-treatment on UV-resistance of Escherichia coli cells.
Topics: Bacterial Proteins; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Fluorouracil; Histidine; Radiation Effects; Radiation-Protective Agents; Thymine; Ultraviolet Rays | 1968 |
Effect of inhibitors of DNA synthesis of UV-sensitive derivatives of Escherichia coli strain K-12.
Topics: DNA; Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Nalidixic Acid; Radiation Effects; Recombination, Genetic; Starvation; Thymine; Ultraviolet Rays | 1970 |
Transport of donor deoxyribonucleic acid into the cell interior of thymine-starved Bacillus subtilis with chromosomes arrested at the terminus.
Topics: Bacillus subtilis; Biological Transport; Cell Division; Chromosome Mapping; Chromosomes, Bacterial; DNA Replication; DNA, Bacterial; Fluorouracil; Muramidase; Protoplasts; Thymine; Transformation, Genetic; Tryptophan | 1969 |
Thymineless death in Lactobacillus acidophilus R-26.
Topics: Adenine Nucleotides; Culture Media; Fluorouracil; Folic Acid; Lactobacillus acidophilus; Thymine | 1970 |
[Protonation of thymine, uracil and its 5-haloid-derivatives].
Topics: Bromouracil; Fluorouracil; Protons; Thymine; Uracil | 1972 |
[Clinical and experimental results of interstitial Brachy-Curie-therapy combined with radiation sensitizing agents in infiltrative growing brain neoplasms].
Topics: Animals; Brain Neoplasms; Bromodeoxyuridine; Carcinosarcoma; Cytidine; Fluorouracil; Guanosine; Iridium; Methotrexate; Neoplasms, Experimental; Radiation-Sensitizing Agents; Rats; Thymine | 1972 |
Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo.
Topics: Animals; Azo Compounds; Dactinomycin; Depression, Chemical; DNA; DNA, Neoplasm; Fluorouracil; Intestine, Small; Iodine Isotopes; Leukemia, Experimental; Liver; Male; Nucleosides; Oxidoreductases; Pyrimidines; Rats; RNA; RNA, Neoplasm; Spleen; Thymidine; Thymine; Tritium; Uracil | 1972 |
Response of DNA thymine synthesis in human tumor and normal tissue to 5-fluorouracil.
Topics: Breast Neoplasms; Carbon Isotopes; Chromatography, Paper; Colon; Colonic Neoplasms; Depression, Chemical; DNA; DNA, Neoplasm; Female; Fluorouracil; Formates; Humans; In Vitro Techniques; Lung Neoplasms; Methyltransferases; Ovarian Neoplasms; Serine; Thymidine; Thymine; Thymine Nucleotides; Tritium; Uracil Nucleotides | 1972 |
In vivo inhibition of pyrimidine catabolism by 5-cyanouracil.
Topics: Animals; Carbon Dioxide; Fluorouracil; Liver; Metabolism; Pyrimidines; Rats; Thymine; Time Factors; Uracil | 1971 |
Gas-liquid chromatography of some pyrimidine derivatives.
Topics: Bromine; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Gas; Cytosine; Fluorouracil; Mathematics; Methods; Phenanthrenes; Pyrimidines; Silicon; Thymine; Triazines; Uracil | 1971 |
Formation and fate of abnormal ribosomes of E. coli cells treated with 5-fluorouracil.
Topics: Adenine Nucleotides; Chemistry Techniques, Analytical; Cytosine Nucleotides; Dactinomycin; Escherichia coli; Fluorouracil; Guanine Nucleotides; In Vitro Techniques; Phosphorus Isotopes; Purines; Pyrimidines; RNA, Bacterial; RNA, Transfer; Thymine; Ultracentrifugation; Uracil Nucleotides | 1965 |
The lethality of streptomycin and the stimulation of RNA synthesis in the absence of protein synthesis.
Topics: Adenine; Arginine; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Drug Resistance, Microbial; Escherichia coli; Fluorouracil; Guanine; Kanamycin; Neomycin; Phosphates; RNA, Bacterial; Streptomycin; Sulfur Isotopes; Thymine; Uracil | 1966 |
Inhibition of repressor formation in the lactose system of Escherichia coli by inhibitors of protein synthesis.
Topics: Antimetabolites; Chloramphenicol; DNA, Bacterial; Enzyme Repression; Escherichia coli; Fluorouracil; Galactosidases; Hot Temperature; Lactose; Mutation; Puromycin; RNA, Bacterial; Thymine; Uracil | 1966 |
Regulation of chromosome replication in Escherichia coli: a comparison of the effects of phenethyl alcohol treatment with those of amino acid starvation.
Topics: Alcohols; Amino Acids; Autoradiography; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Chromosomes; DNA, Bacterial; Escherichia coli; Fluorouracil; Thymine | 1966 |
The effect of 5-fluorouracil on DNA-thymine synthesis in human tumors.
Topics: Carbon Isotopes; DNA, Neoplasm; Fluorouracil; Formates; Humans; Neoplasms; Thymidine; Thymine; Tritium | 1969 |
[New possibilities in the treatment of epithelioma].
Topics: Animals; Fluorouracil; Humans; Precancerous Conditions; Rats; Skin Neoplasms; Thymine; Uracil | 1969 |
A new paper chromatography solvent system resolving pyrimidine-pyrimidine riboside-pyrimidine deoxyriboside mixtures.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Chromatography, Paper; Culture Techniques; Cytosine Nucleotides; DNA; Fluorouracil; Guanine Nucleotides; Methods; Nucleosides; Pyrimidines; Solvents; Spectrophotometry; Thymidine; Thymine; Ultraviolet Rays; Uracil Nucleotides | 1969 |
A new method for treatment of carcinoma of the breast and colon with 5-fluorouracil.
Topics: Adult; Aged; Breast Neoplasms; Chemical Phenomena; Chemistry; Colonic Neoplasms; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Thymine; Uracil | 1970 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. I. Biological aspects.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Carbon Tetrachloride Poisoning; Drug Synergism; Embryo, Mammalian; Female; Fluorouracil; Injections, Intraperitoneal; Kidney; Liver; Male; Maternal-Fetal Exchange; Pregnancy; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1969 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. II. Biochemical aspects.
Topics: Animals; Carbon Isotopes; Depression, Chemical; DNA; Drug Synergism; Embryo, Mammalian; Extraembryonic Membranes; Female; Fluorouracil; Formates; Injections, Intraperitoneal; Ligases; Liver; Male; Phosphorus; Phosphorus Isotopes; Pregnancy; Rats; Thymidine; Thymidine Kinase; Thymine; Uracil | 1969 |
[Effects of 5-fluorouracil and 6-methylpurine on development of the egg of the sea urchin Paracentrotus lividus].
Topics: Animals; Antimetabolites; DNA; Echinodermata; Embryo, Nonmammalian; Female; Fluorouracil; In Vitro Techniques; Ovum; RNA; Thymine; Uracil | 1965 |
Effects of ultraviolet radiation on RNA C-C glycosyls and other derivatives of uracil.
Topics: Chemical Phenomena; Chemistry, Physical; Fluorouracil; Nucleosides; Radiation Effects; RNA, Transfer; Spectrophotometry; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uridine | 1966 |
Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
Topics: Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Rectal Neoplasms; Thymidine; Thymine | 1982 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug Synergism; Fluorouracil; Neoplasms, Experimental; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentosyltransferases; Phosphorylation; Pyrimidines; Sarcoma, Yoshida; Tegafur; Thymidine; Thymine; Uracil; Uridine | 1984 |
Effects of thymidine and thymidine plus 5-fluorouracil on the growth kinetics of a human lymphoid cell line.
Topics: Cell Cycle; Cell Division; Cell Line; Cell Survival; DNA Replication; Floxuridine; Fluorouracil; Humans; Thymidine; Thymine | 1980 |
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Liver; Male; Mice; Phosphorylation; Rats; Sarcoma 180; Sarcoma, Yoshida; Tegafur; Thymidine; Thymidine Phosphorylase; Thymine; Uracil; Uridine; Uridine Phosphorylase | 1980 |
Determination of 5-fluorouracil and pyrimidine bases in plasma by gas chromatography-chemical ionization-mass fragmentography.
Topics: Cytosine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Ions; Pyrimidines; Tegafur; Thymine; Uracil | 1980 |
Nonlinear pharmacokinetics of thymidine, thymine, and fluorouracil and their kinetic interactions in normal dogs.
Topics: Animals; Dogs; Drug Interactions; Fluorouracil; Kinetics; Metabolic Clearance Rate; Thymidine; Thymine | 1983 |
Clinical pharmacologic effects of thymidine plus 5-FU.
Topics: Adult; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leukocyte Count; Male; Middle Aged; Neoplasms; Platelet Count; Thymidine; Thymine; Time Factors | 1980 |
cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 1; Cricetinae; Dihydrouracil Dehydrogenase (NADP); DNA, Complementary; Fluorouracil; Humans; Hybrid Cells; Metabolism, Inborn Errors; Mice; Molecular Sequence Data; Oxidoreductases; Recombinant Proteins; Swine; Thymine; Uracil | 1994 |
Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Deoxyribonucleosides; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Humans; Interferon alpha-2; Interferon-alpha; Recombinant Proteins; Stimulation, Chemical; Thymidine Phosphorylase; Thymidylate Synthase; Thymine; Tritium; Tumor Cells, Cultured | 1994 |
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Lymphoma, Large B-Cell, Diffuse; Mice; Molecular Structure; Neoplasm Transplantation; Structure-Activity Relationship; Thymine; Tumor Cells, Cultured; Uracil | 1993 |
Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU).
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Codon; Colonic Neoplasms; Disease Progression; DNA, Neoplasm; Drug Resistance, Neoplasm; Exons; Female; Fluorouracil; Forecasting; Genes, ras; Guanine; Humans; Irinotecan; Male; Middle Aged; Mutation; Prognosis; Retreatment; Sequence Analysis, DNA; Survival Rate; Thymine; Treatment Failure | 1997 |
Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil.
Topics: Animals; Biological Availability; Biotransformation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Intestinal Mucosa; Kinetics; Liver; Mice; Oxidoreductases; Rats; Species Specificity; Thymidine; Thymine; Uracil | 1998 |
[A case of gastric cancer with decreased dihydropyrimidine dehydrogenase activity].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Oxidoreductases; Pyrimidines; Stomach Neoplasms; Thymine; Uracil | 1998 |
Population and family studies of dihydropyrimidinuria: prevalence, inheritance mode, and risk of fluorouracil toxicity.
Topics: Adult; Amidohydrolases; Child; Child, Preschool; Female; Fluorouracil; Genes, Recessive; Homozygote; Humans; Infant; Japan; Male; Metabolism, Inborn Errors; Nuclear Family; Prevalence; Pyrimidines; Risk; Thymine; Uracil | 1998 |
Characterization of the human dihydropyrimidine dehydrogenase gene.
Topics: Alleles; Cloning, Molecular; Dihydrouracil Dehydrogenase (NADP); Exons; Fluorouracil; Gene Dosage; Humans; Introns; Leukocytes; Neoplasm Proteins; Oxidoreductases; Point Mutation; Polymerase Chain Reaction; Restriction Mapping; RNA Splicing; RNA, Messenger; Thymine; Uracil | 1998 |
Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.
Topics: Cell Death; Cell Survival; Clone Cells; Deoxyadenine Nucleotides; Deoxyadenosines; Fluorouracil; Humans; Kinetics; Leucovorin; Nucleosomes; Thymine; Thymine Nucleotides; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1995 |
Possible prediction of adverse reactions to fluorouracil by the measurement of urinary dihydrothymine and thymine.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Infant; Infant, Newborn; Male; Middle Aged; Predictive Value of Tests; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Reference Values; Thymine | 1998 |
Rapid detection of a common dihydropyrimidine dehydrogenase mutation associated with 5-fluorouracil toxicity and congenital thymine uraciluria using fluorogenic hybridization probes.
Topics: Alleles; Antimetabolites; Dihydrouracil Dehydrogenase (NADP); Fluorescent Dyes; Fluorouracil; Genotype; Humans; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Oxidoreductases; Polymorphism, Genetic; Sequence Analysis, DNA; Temperature; Thymine; Uracil | 2001 |
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.
Topics: Adult; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Exons; Fatal Outcome; Female; Fibroblasts; Fluorouracil; Gene Frequency; Humans; Leukocytes, Mononuclear; Mutation; Oxidoreductases; Polymorphism, Restriction Fragment Length; Thymine; Uracil | 2001 |
Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure.
Topics: Age of Onset; Amino Acids; Animals; Cells, Cultured; Child, Preschool; Crystallography, X-Ray; Dihydrouracil Dehydrogenase (NADP); Electron Transport; Exons; Fibroblasts; Fluorouracil; Gene Deletion; Genotype; Granulocytes; Humans; Infant; Infant, Newborn; Intellectual Disability; Leukocytes, Mononuclear; Models, Molecular; Motor Skills Disorders; Mutation; Mutation, Missense; Oxidoreductases; Phenotype; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Pyrimidines; Swine; Thymine; Uracil | 2002 |
Development and characterization of a monoclonal antibody with cross-reactivity towards uracil and thymine, and its potential use in screening patients treated with 5-fluorouracil for possible risks.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Contraindications; Cross Reactions; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Fluorouracil; Humans; Hybridomas; Mice; Mice, Inbred BALB C; Oxidoreductases; Pyrimidines; Risk Factors; Thymine; Uracil | 2002 |
In vitro synthesis of acidsoluble thymine compounds by human neoplastic tissues.
Topics: DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Neoplasms; Thymine | 1963 |
FLUORINATED PYRIMIDINES. XIX. SOME BIOLOGICAL EFFECTS OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE ON ESCHERICHIA COLI AND BACTERIOPHAGE T4B.
Topics: Antimetabolites; Carbon Isotopes; Chromatography; Coliphages; Escherichia coli; Floxuridine; Fluorouracil; Metabolism; Mutation; Pharmacology; Pyrimidines; Research; Thymine; Trifluridine; Virus Cultivation | 1963 |
PHYSIOLOGICAL EVIDENCE ON THE NATURE OF THE REPRESSOR OF ALKALINE PHOSPHATASE SYNTHESIS IN ESCHERICHIA COLI.
Topics: Alkaline Phosphatase; Bacterial Proteins; Chloramphenicol; Culture Media; Enzyme Inhibitors; Escherichia coli; Fluorouracil; Leucine; Metabolism; Mutation; Pharmacology; Phosphates; Proteins; Research; Temperature; Thymine | 1964 |
THE EFFECT OF NATURAL AND UNNNATURAL PYRIMIDINES AND PYRIMIDINE NUCLEOSIDES ON THE PHOSPHOROLYSIS OF 5-IODODEOXYURIDINE BY MOUSE LIVER EXTRACT.
Topics: Animals; Chromatography; Deoxyuridine; Floxuridine; Fluorouracil; Idoxuridine; Iodine Isotopes; Liver; Liver Extracts; Metabolism; Mice; Nucleosides; Pharmacology; Phosphotransferases; Pyrimidine Nucleosides; Pyrimidines; Research; Thymidine; Thymine; Uracil | 1964 |
EVIDENCE FOR TWO DISTINCT ASPECTS OF THE MECHANISM REGULATING CHROMOSOME REPLICATION IN ESCHERICHIA COLI.
Topics: Amino Acids; Bacterial Proteins; Chloramphenicol; Chromosomes; Cytosine; DNA; DNA, Bacterial; Escherichia coli; Fluorouracil; Metabolism; Pharmacology; Proteins; Research; RNA; RNA, Bacterial; Thymine | 1964 |
[MACROMOLECULAR MODIFICATIONS IN A PATHOGENIC BACTERIUM BY MEANS OF ANTIMETABOLITES OF NUCLEIC ACIDS: COMPARATIVE EFFECTS OF 5-FLUOROURACIL AND ACRIDINE ORANGE ON VIRULENCE INDICATORS IN STAPHYLOCOCCUS AUREUS].
Topics: Acridine Orange; Acridines; Antigens; Antimetabolites; DNA; DNA, Bacterial; Fluorescence; Fluorouracil; Immunodiffusion; Microscopy; Microscopy, Fluorescence; Pharmacology; Research; RNA; RNA, Bacterial; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus; Thymine; Uracil; Virulence | 1964 |
[RESEARCH ON THE MECHANISM OF INDUCTION. 8. THE EFFECT OF 5-FLUOROURACIL ON INDUCTION BY MEANS OF THYMINE DEFICIENCY].
Topics: Bacteriolysis; Coliphages; Floxuridine; Fluorouracil; Genetics; Pharmacology; Research; Thymine | 1964 |
FLUORINATED PYRIMIDINES. XXII. EFFECTS OF VARIOUS COMPOUNDS ON THE INCORPORATION OF (14C)FORMATE INTO DNA THYMINE IN SUSPENSIONS OF EHRLICH ASCITES CELLS.
Topics: Animals; Antineoplastic Agents; Ascites; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Formates; Metabolism; Mutagens; Pharmacology; Pyrimidines; Research; Suspensions; Thymine; Tissue Culture Techniques | 1964 |
INFLUENCE OF PURINE AND PYRIMIDINE COMPOUNDS ON DNA-SYNTHESIS OF ASCITES-TUMOUR CELLS.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Cytosine Nucleotides; DNA; DNA, Neoplasm; Fluorouracil; Metabolism; Neoplasms, Experimental; Nucleotides; Pharmacology; Phosphorus Isotopes; Purines; Pyrimidines; Research; Thymine; Uracil; Uracil Nucleotides | 1964 |
UPTAKE AND INCORPORATION OF THYMINE, THYMIDINE, URACIL, URIDINE, AND 5-FLUOROURACIL INTO THE NUCLEIC ACIDS OF BACILLUS SUBTILIS.
Topics: Bacillus subtilis; Carbon Isotopes; DNA; DNA, Bacterial; Fluorouracil; Metabolism; Nucleosides; Research; RNA; RNA, Bacterial; Thymidine; Thymine; Tritium; Uracil; Uridine | 1965 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
[ON THE EFFECT OF 5-BROMOURACIL AND 5-FLUOROURACIL ON THE VIRUS INDUCTION OF A LYSOGENIC THYMINE-LESS MUTANT OF E. COLI BY MEANS OF ULTRAVIOLET RAYS].
Topics: Bromouracil; Coliphages; DNA; Escherichia coli; Fluorouracil; Lysogeny; Research; Thymine; Ultraviolet Rays; Uracil; Virus Activation | 1964 |
Effects of 5-fluorodeoxyuridine and related halogenated pyrimidines on the sand-dollar embryo.
Topics: Cytidine; DNA; Female; Floxuridine; Fluorouracil; Humans; Orotic Acid; Pregnancy; Pyrimidines; Thymidine; Thymine; Uridine | 1960 |
Permeability of Ehrlich cells to uracil, thymine and fluorouracil.
Topics: Fluorouracil; Humans; Neoplasms; Permeability; Thymine; Uracil | 1962 |
New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?
Topics: Aminoisobutyric Acids; beta-Alanine; Brain Diseases, Metabolic, Inborn; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Homeostasis; Humans; Inactivation, Metabolic; Neurotransmitter Agents; Purine-Pyrimidine Metabolism, Inborn Errors; Stereoisomerism; Thymine; Uracil; Valine | 2004 |
Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate.
Topics: Alanine; Animals; Antimetabolites, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cytosine; DNA Probes; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genotype; Humans; Leucovorin; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Polymorphism, Genetic; Random Allocation; Thymidylate Synthase; Thymine; Transfection; Transplantation, Heterologous; Valine | 2004 |
A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells.
Topics: Animals; Antimetabolites; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; Coloring Agents; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Globins; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Chemical; Neoplasm Metastasis; Neoplasm Transplantation; Polymerase Chain Reaction; Pyrrolidines; Sensitivity and Specificity; Tetrazolium Salts; Thiazoles; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil | 2004 |
A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Combinations; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pyrrolidines; Rats; Rats, Nude; Stomach Neoplasms; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2004 |
Dihydropyrimidine dehydrogenase deficiency presenting at birth.
Topics: Age of Onset; Antimetabolites; Binding Sites; Digestive System Abnormalities; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Genes, Recessive; Heterozygote; Homozygote; Humans; Infant, Newborn; Muscular Diseases; Mutation; Purine-Pyrimidine Metabolism, Inborn Errors; Thymine; Uracil | 2005 |
Trypanosoma brucei: a survey of pyrimidine transport activities.
Topics: Animals; Antimetabolites; Biological Transport; Cytidine; Cytosine; Female; Fluorouracil; Parasitic Sensitivity Tests; Pyrimidines; Rats; Rats, Wistar; Thymidine; Thymine; Trypanocidal Agents; Trypanosoma brucei brucei; Uridine | 2006 |
Excited-state structural dynamics of 5-fluorouracil.
Topics: Absorption; Binding Sites; DNA; Fluorouracil; Methane; Molecular Conformation; Photochemistry; RNA; Spectrum Analysis, Raman; Thymine; Time Factors; Ultraviolet Rays | 2006 |
Michael addition of pyrimidine with disaccharide acrylates catalyzed in organic medium with lipase M from Mucor javanicus.
Topics: Acrylates; Disaccharides; Fluorouracil; Lipase; Mucor; Thymine; Uracil | 2006 |
Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma.
Topics: Adenine; Aged; Alleles; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; DNA, Complementary; Exons; Fatal Outcome; Female; Fluorouracil; Gene Frequency; Humans; Introns; Mutation; Pedigree; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Thymine; Uracil | 2007 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Pyrrolidines; Sensitivity and Specificity; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Tumor Cells, Cultured; Uracil; Xenograft Model Antitumor Assays | 2007 |
An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents.
Topics: Antineoplastic Agents; Antiviral Agents; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Intestines; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Rotavirus; Stereoisomerism; Structure-Activity Relationship; Thymine; Uracil; Xylose; Zidovudine | 2007 |
Effects of folate cycle disruption by the green tea polyphenol epigallocatechin-3-gallate.
Topics: Adenosine; Apoptosis; Caco-2 Cells; Camellia sinensis; Caspase 3; Catechin; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; DNA Methylation; DNA Replication; Fluorouracil; Folic Acid Antagonists; Gene Expression; Humans; Hypoxanthine; Leucovorin; Models, Biological; NF-kappa B; Protein Binding; Receptor, Adenosine A3; Tetrahydrofolate Dehydrogenase; Thymine; Transcription, Genetic | 2007 |
Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cytosine; Drug Screening Assays, Antitumor; Fluorouracil; HeLa Cells; Humans; Mice; Nucleosides; Stereoisomerism; Thymine; Uracil | 2010 |
Efficient synthesis of exomethylene- and keto-exomethylene-d-glucopyranosyl nucleoside analogs as potential cytotoxic agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cytotoxins; Fluorouracil; Humans; Inhibitory Concentration 50; Mice; Nucleosides; Thymine; Uracil | 2011 |
Nonradiative deactivation mechanisms of uracil, thymine, and 5-fluorouracil: a comparative ab initio study.
Topics: Fluorouracil; Molecular Structure; Photochemical Processes; Quantum Theory; Solutions; Thermodynamics; Thymine; Ultraviolet Rays; Uracil | 2012 |
Stereocontrolled synthesis of 4'-C-cyano and 4'-C-cyano-4'-deoxy pyrimidine pyranonucleosides as potential chemotherapeutic agents.
Topics: Acetylation; Antineoplastic Agents; Cytostatic Agents; Drug Design; Fluorouracil; HeLa Cells; Humans; Inhibitory Concentration 50; Mannose; Nitriles; Oxidation-Reduction; Oxygen; Pyrimidine Nucleosides; Sodium Cyanide; Stereoisomerism; Thymine; Uracil | 2012 |
Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, with irinotecan hydrochloride on human colorectal and gastric cancer xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Irinotecan; Male; Mice; Pyrrolidines; Stomach Neoplasms; Thymine; Trifluridine; Uracil; Xenograft Model Antitumor Assays | 2015 |
Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; DNA, Neoplasm; Drug Combinations; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Fluorouracil; HCT116 Cells; Humans; Male; Pyrophosphatases; Pyrrolidines; Substrate Specificity; Thymidine Kinase; Thymine; Trifluridine; Uracil | 2015 |
Preliminary Evidence for Enhanced Thymine Absorption: A Putative New Phenotype Associated With Fluoropyrimidine Toxicity in Cancer Patients.
Topics: Adult; Aged; Amidohydrolases; Capecitabine; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Phenotype; Thymine | 2018 |
Fluoropyrimidines and DPD testing: is there truly an inexorable link?
Topics: Antineoplastic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fluorouracil; Genotype; Humans; Neoplasms; Oxonic Acid; Pharmacogenomic Testing; Phenotype; Point-of-Care Testing; Pyrrolidines; Tegafur; Thymine; Trifluridine; Uracil | 2019 |
Pharmacological effects of the simultaneous and sequential combinations of trifluridine/tipiracil (TAS-102) and 5-fluorouracil in fluoropyrimidine-sensitive colon cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Colonic Neoplasms; Drug Combinations; Drug Synergism; Fluorouracil; Humans; Pyrrolidines; Thymine; Trifluridine; Tumor Cells, Cultured | 2020 |
CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure.
Topics: AC133 Antigen; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colon; Drug Combinations; Drug Synergism; Fluorouracil; Gene Expression; Humans; Hyaluronan Receptors; Inhibitory Concentration 50; Neoplastic Stem Cells; Pyrrolidines; Spheroids, Cellular; Thymidine Kinase; Thymine; Trifluridine | 2019 |
A case-control study to assess the ability of the thymine challenge test to predict patients with severe to life threatening fluoropyrimidine-induced gastrointestinal toxicity.
Topics: Capecitabine; Case-Control Studies; Diagnostic Tests, Routine; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Thymine | 2020 |
Review of metastatic colorectal cancer treatment pathways and early clinical experience of trifluridine/tipiracil in the UK named patient programme.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Disease Progression; Drug Combinations; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine; United Kingdom; Uracil | 2020 |
Evaluation of RAS mutational status through BEAMing assay to monitor disease progression of metastatic colorectal cancer: a case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Capecitabine; Cetuximab; Colorectal Neoplasms; Disease Progression; DNA Mutational Analysis; Drug Combinations; Fluorouracil; Humans; Leucovorin; Liquid Biopsy; Male; Middle Aged; Mutation; Phenylurea Compounds; Pyridines; Pyrrolidines; ras Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thymine; Trifluridine | 2020 |
[Case Series of the TAS-102 plus Bevacizumab(Bev)Combination Therapy in Unresectable Advanced Colorectal Cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Humans; Neoplasm Recurrence, Local; Pyrrolidines; Thymine; Treatment Outcome; Trifluridine | 2020 |
Mechanism of acquired 5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Metabolic Networks and Pathways; Pyrrolidines; Ribonucleotide Reductases; Thymidine Phosphorylase; Thymine; Trifluridine | 2021 |
Kinetic Analysis of the Effect of
Topics: Acetylation; DNA Repair; Fluorouracil; Kinetics; Lysine; Thymine; Thymine DNA Glycosylase | 2022 |
Quantification of uracil, dihydrouracil, thymine and dihydrothymine for reliable dihydropyrimidine dehydrogenase (DPD) phenotyping critically depend on blood and plasma storage conditions.
Topics: Biomarkers; Capecitabine; Chromatography, Liquid; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Tandem Mass Spectrometry; Thymine; Uracil | 2022 |
Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism.
Topics: Antimetabolites; Cytarabine; Floxuridine; Fluorouracil; Gemcitabine; Nucleosides; Pyrimidines; Tetrahymena thermophila; Thymine; Uracil | 2023 |