thymidine has been researched along with thymine arabinoside in 59 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (62.71) | 18.7374 |
| 1990's | 9 (15.25) | 18.2507 |
| 2000's | 11 (18.64) | 29.6817 |
| 2010's | 2 (3.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, MS; Prusoff, WH; Schinazi, RF | 1 |
| Herdewijn, P; Munier-Lehmann, H; Pochet, S; Van Calenbergh, S; Van Rompaey, P; Vanheusden, V | 1 |
| Iltis, JP; Miller, RL; Rapp, F | 1 |
| Allen, GP; Gentry, GA; McGowan, JJ; Randall, CC | 1 |
| Falke, D; Link, D; Moser, H; Müller, WE | 2 |
| Barnett, JM; Gentry, GA; McGowan, JJ | 2 |
| Arendes, J; Beyer, R; Maidhof, A; Müller, WE; Zahn, RK | 1 |
| Arnér, ES; Eriksson, S; Spasokoukotskaja, T | 1 |
| Adams, AD; Meyer, RB; Petrie, CR | 1 |
| Haritani, M; Imada, T; Narita, M | 1 |
| Blair, ED; Snowden, BW; Wagner, EK | 1 |
| Barry, DW; Ellis, MN; Fyfe, JA; Keller, PM; Lehrman, SN; Martin, JL; Rooney, JF; Straus, SE | 1 |
| Machida, H; Sakuma, T; Suzutani, T | 1 |
| Coen, DM; Fleming, HE; Leslie, LK; Retondo, MJ | 1 |
| Gentry, GA; Lawrence, N; Lushbaugh, W | 1 |
| Edris, WA; Tenser, RB | 1 |
| Allen, LB; Löbering, HG; Maidhof, A; Müller, WE; Schröder, HC | 1 |
| Baskin, G; Cantrell, C; Gerone, P; Soike, KF | 1 |
| Janz, C; Wigand, R | 1 |
| Burkhardt, U; Wigand, R | 1 |
| Friedman-Kien, AE; Klein, RJ | 1 |
| Calender, A; Ooka, T | 1 |
| Darby, G; Field, H; McMillan, A | 1 |
| Dunstan, ME; Ressel, S; Tenser, RB | 1 |
| Klein, G; Roubal, J | 1 |
| Hinuma, Y; Sairenji, T; Yonemura, K | 1 |
| Gentry, GA; Veerisetty, V | 2 |
| de Clercq, E | 1 |
| Kiyanagi, T; Kuninaka, A; Machida, H; Morozumi, M; Sakata, S; Yoshino, H | 1 |
| Calender, A; Daillie, J; de Turenne, M; Ooka, T | 1 |
| Inoue, S; Shiota, H | 1 |
| Bastow, KF; Cheng, YC; Derse, DD | 1 |
| Kit, S; Qavi, H | 1 |
| Allaudeen, HS; Chen, HC; De Clercq, E; Liu, YX; Zhang, ZX | 1 |
| Gangarosa, LP; Gentry, GA; Hill, JM; Kwon, BS; Wiggins, CA | 1 |
| Albert, DM; De Clercq, E; Hettinger, ME; Lin, TS; Park, NH; Pavan-Langston, D | 1 |
| Allen, GP; Barnett, JM; Gentry, GA; McGowan, JJ | 1 |
| Ichikawa, M; Kuninaka, A; Machida, H; Saneyoshi, M; Yoshino, H | 1 |
| Li, YY; Minagawa, H; Mori, R; Tanaka, S | 1 |
| Breakefield, XO; Davidson, BL; Hughes, TL; Roessler, BJ; Shewach, DS; Zerbe, LK | 1 |
| Hanson, LA; Kousoulas, KG; Thune, RL | 1 |
| Smith, G | 1 |
| Gotfredsen, CH; Jacobsen, JP; Wengel, J | 1 |
| Davidson, BL; Rubsam, LZ; Shewach, DS | 1 |
| Johansson, M; Karlsson, A; Zheng, X | 2 |
| Balzarinia, J; De Clercq, E; Degrève, B; Durini, E; Karlsson, A; Manfredini, S; Porcu, L; Zhu, C | 1 |
| Hernández, B; Hernanz, A; Navarro, R; Vergoten, G | 1 |
| Johansson, M; Karlsson, A; Lundberg, M; Zheng, X | 1 |
| Filichev, VV; Pedersen, EB | 1 |
| Balzarini, J; Bormans, G; Celen, S; de Groot, T; Karlsson, A; Verbruggen, A | 1 |
| Balzarini, J; Bianchi, V; Franzolin, E; Hernández, AI; Pérez-Pérez, MJ; Rampazzo, C | 1 |
| Balzarini, J; Camarasa, MJ; Familiar, O; Gago, F; Hernandez, AI; Karlsson, A; Negri, A; Pérez-Pérez, MJ; Rodríguez-Barrios, F | 1 |
| Balzarini, J; Curbo, S; Johansson, M; Karlsson, A; Lewis, LD | 1 |
| Mao, L; Sun, Z; Wang, Z; Xu, H; Zhao, L; Zheng, X; Zhu, Z | 1 |
| Gu, M; Jiang, H; Sun, Y; Zheng, X | 1 |
1 review(s) available for thymidine and thymine arabinoside
| Article | Year |
|---|---|
Nucleoside analogues as antiviral agents.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Chemical Phenomena; Chemistry; Cytarabine; Deoxyuridine; Guanine; Herpesviridae Infections; Humans; Idoxuridine; Nucleosides; Ribavirin; Thymidine; Virus Diseases; Viruses | 1981 |
58 other study(ies) available for thymidine and thymine arabinoside
| Article | Year |
|---|---|
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cells, Cultured; Kinetics; Leukemia L1210; Mice; Pyrimidine Nucleosides; Sarcoma 180; Simplexvirus | 1979 |
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Topics: Antitubercular Agents; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Mycobacterium tuberculosis; Nucleoside-Phosphate Kinase; Structure-Activity Relationship; Thymidine; Thymine Nucleotides | 2003 |
Differential effect of arabinofuranosylthymine of the replication of human herpesviruses.
Topics: Arabinonucleosides; Arabinose; Cell Line; Cytomegalovirus; Cytopathogenic Effect, Viral; DNA Replication; DNA, Viral; Herpesvirus 3, Human; Humans; Simplexvirus; Thymidine; Virus Replication | 1977 |
Biochemical transformation of deoxythymidine kinase-deficient mouse cells with UV-irradiated equine herpesvirus type 1.
Topics: Animals; Antigens, Viral; Arabinonucleosides; Cell Division; Cell Line; Cell Transformation, Viral; Herpesviridae; Herpesvirus 1, Equid; Mice; Mice, Nude; Neoplasms, Experimental; Phenotype; Thymidine; Thymidine Kinase; Ultraviolet Rays | 1978 |
The effect of 1-beta-D-arabinofuranosylthymine on the growth of herpes simplex virus types 1 and 2.
Topics: Animals; Arabinonucleosides; Cell Line; Cricetinae; Deoxycytidine Kinase; Rabbits; Simplexvirus; Thymidine; Thymidine Kinase; Virus Replication | 1979 |
The effects of alpha- and beta-D-arabinosyladenosine and beta-D-arabinosylthymine on the synthesis of HSV types 1- and 2-infected cells.
Topics: Animals; Arabinonucleosides; Kidney; Phosphorylation; Rabbits; Simplexvirus; Thymidine; Thymidine Kinase; Thymine; Vidarabine; Virus Cultivation; Virus Replication | 1979 |
Arabinosylthymine: inhibitor of splenic lymphocyte macromolecular synthesis in vitro.
Topics: Animals; Arabinonucleosides; Concanavalin A; Cricetinae; Cytarabine; DNA; Lymphocyte Activation; Lymphocytes; Protein Biosynthesis; Thymidine; Thymidine Kinase | 1979 |
Arabinosyl nucleosides. XII. Influence of arabino-furanosylthymine on growth of L5178y cells.
Topics: Arabinonucleosides; Cell Division; DNA; L Cells; Phosphorylation; Thymidine | 1978 |
Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.
Topics: Arabinonucleosides; Cladribine; Deoxycytidine; Deoxycytidine Kinase; Humans; Isoenzymes; Kinetics; Leukemia; Leukocytes; Mitochondria; Organ Specificity; Phosphorylation; Radioisotope Dilution Technique; Reference Values; Substrate Specificity; Thymidine; Thymidine Kinase; Tritium; Tumor Cells, Cultured; Zidovudine | 1992 |
Preparation and hybridization properties of oligonucleotides containing 1-alpha-D-arabinofuranosylthymine.
Topics: Arabinonucleosides; Benzene; DNA; Kinetics; Nucleic Acid Heteroduplexes; Nucleic Acid Hybridization; Oligonucleotides, Antisense; Poly A; Poly T; RNA; Temperature; Thymidine | 1991 |
Comparative pathology of HPCD pigs infected with wild-type and ara-T-resistant strains of Aujeszky's disease virus.
Topics: Animals; Antigens, Viral; Antiviral Agents; Arabinonucleosides; Colostrum; Drug Resistance, Microbial; Female; Herpesvirus 1, Suid; Hysterectomy; Immunohistochemistry; Pseudorabies; Swine; Thymidine | 1990 |
Transcriptional activation is not responsible for increased levels of autonomously expressed simian virus 40 T-antigen in herpes simplex virus-infected cells.
Topics: Animals; Antigens, Viral, Tumor; Antiviral Agents; Arabinonucleosides; Cell Line; DNA Replication; DNA, Viral; Fluorescent Antibody Technique; Gene Amplification; Gene Expression Regulation; Genetic Markers; Metallothionein; Metals; Mice; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Simian virus 40; Simplexvirus; Thymidine; Transcription, Genetic; Transfection | 1989 |
Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.
Topics: Acyclovir; Adult; Animals; Antiviral Agents; Arabinonucleosides; Cloning, Molecular; DNA Restriction Enzymes; DNA, Viral; Drug Resistance, Microbial; Enzyme Induction; Female; Herpes Simplex; Humans; Kinetics; Male; Mice; Mice, Inbred BALB C; Phosphorylation; Recurrence; Simplexvirus; Substrate Specificity; Thymidine; Thymidine Kinase; Vero Cells | 1987 |
Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells.
Topics: Acyclovir; Aminopterin; Animals; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Dose-Response Relationship, Drug; Fibroblasts; Humans; Idoxuridine; Lung; Nucleosides; Simplexvirus; Thymidine; Vero Cells; Vidarabine | 1988 |
Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus.
Topics: Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Foscarnet; Ganciclovir; Genes, Viral; Idoxuridine; Mutation; Phosphonoacetic Acid; Simplexvirus; Thymidine; Vidarabine | 1985 |
Isolation and differentiation of herpes simplex virus and Trichomonas vaginalis in cell culture.
Topics: Animals; Arabinonucleosides; Cells, Cultured; Cricetinae; Cytopathogenic Effect, Viral; Diagnosis, Differential; Female; Herpes Simplex; Humans; Male; Simplexvirus; Thymidine; Trichomonas vaginalis; Trichomonas Vaginitis | 1985 |
Thymidine kinase (TK) activity in herpes simplex virus type 1 recombinants that carry insertions affecting regulation of the TK gene.
Topics: Animals; Arabinonucleosides; Cell Line; Gene Expression Regulation; Simplexvirus; Thymidine; Thymidine Kinase; Vero Cells; Viral Plaque Assay; Virus Replication | 1986 |
Cytostatic and antiherpesvirus type 1 and 2 activities of 1-beta-D-arabinofuranosylthymine (ara T) prodrugs.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinonucleosides; Cell Line; Leukemia L5178; Mice; Simplexvirus; Thymidine | 1987 |
Investigation of antiviral activity of 1-beta-D-arabinofuranosylthymine (ara-T) and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-ara-U) in monkeys infected with simian varicella virus.
Topics: Animals; Arabinofuranosyluracil; Arabinonucleosides; Chickenpox; Chlorocebus aethiops; Herpesviridae Infections; Nervous System; Neurons; Thymidine; Uridine | 1984 |
Combined interaction of antiherpes substances and interferon beta on the multiplication of herpes simplex virus.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinonucleosides; Cell Line; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Deoxyuridine; Drug Interactions; Foscarnet; Interferon Type I; Phosphonoacetic Acid; Simplexvirus; Tegafur; Thymidine; Vidarabine Phosphate | 1982 |
Combined chemotherapy of cutaneous herpes simplex infection of the guinea pig.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinonucleosides; Deoxyuridine; Drug Therapy, Combination; Female; Foscarnet; Guinea Pigs; Herpes Simplex; Idoxuridine; Male; Phosphonoacetic Acid; Skin Diseases, Infectious; Thymidine; Trifluridine; Vidarabine Phosphate | 1983 |
Effect of eight antiviral drugs on the reactivation of herpes simplex virus in explant cultures of latently infected mouse trigeminal ganglia.
Topics: Acyclovir; Animals; Antibodies, Viral; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Bromodeoxyuridine; Culture Media; Culture Techniques; Cytarabine; Foscarnet; Mice; Mice, Hairless; Neutralization Tests; Phosphonoacetic Acid; Simplexvirus; Thymidine; Trigeminal Nerve; Vidarabine Phosphate; Virus Activation | 1984 |
Effects of arabinofuranosylthymine on Epstein-Barr virus replication.
Topics: Arabinonucleosides; Burkitt Lymphoma; Butyrates; Cell Line; DNA, Viral; Herpesvirus 4, Human; Humans; Mutation; Tetradecanoylphorbol Acetate; Thymidine; Thymidine Kinase; Virus Activation; Virus Replication | 1980 |
The sensitivity of acyclovir-resistant mutants of herpes simplex virus to other antiviral drugs.
Topics: Acyclovir; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Drug Resistance, Microbial; Foscarnet; Guanine; Microbial Sensitivity Tests; Mutation; Phosphonoacetic Acid; Simplexvirus; Thymidine; Trifluridine; Vidarabine | 1981 |
Herpes simplex virus thymidine kinase expression in trigeminal ganglion infection: correlation of enzyme activity with ganglion virus titer and evidence of in vivo complementation.
Topics: Animals; Arabinonucleosides; Cornea; Female; Genetic Complementation Test; Male; Mice; Mutation; Phosphorylation; Simplexvirus; Thymidine; Thymidine Kinase; Trigeminal Ganglion; Trigeminal Nerve | 1981 |
Synthesis of thymidine kinase (TK) in Epstein-Barr virus-superinfected Raji TK-negative cells.
Topics: Arabinonucleosides; Cell Line; Cytarabine; Enzyme Induction; Herpesvirus 4, Human; Humans; Substrate Specificity; Thymidine; Thymidine Kinase | 1981 |
Inhibitory effect of 1-beta-D-arabinofuranosylthymine on synthesis of Epstein-Barr virus.
Topics: Antigens, Viral; Antiviral Agents; Arabinonucleosides; Capsid Proteins; Cell Division; Cell Line; Herpesvirus 4, Human; Humans; Thymidine; Virus Replication | 1981 |
5-Methoxymethyldeoxyuridine-resistant mutants of herpes simplex virus type 1.
Topics: Acyclovir; Animals; Arabinonucleosides; Bromodeoxyuridine; Cell Line; Deoxyuridine; Drug Resistance, Microbial; Enzyme Induction; Guanine; Mice; Mutation; Phosphonoacetic Acid; Simplexvirus; Thymidine; Thymidine Kinase | 1981 |
Comparison of the in vitro and in vivo anti-herpes activities of 1-beta-D-arabinofuranosylthymine and its 5'-monophosphate.
Topics: Animals; Antiviral Agents; Arabinonucleosides; Arabinonucleotides; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Encephalitis; Herpes Simplex; Humans; Kinetics; Mice; Simplexvirus; Thymidine; Viral Plaque Assay | 1982 |
Effect of arabinofuranosylthymine on the replication of Epstein-Barr virus and relationship with a new induced thymidine kinase activity.
Topics: Antigens, Viral; Arabinonucleosides; Arabinonucleotides; DNA Polymerase I; DNA Replication; DNA, Viral; Enzyme Induction; Herpesvirus 4, Human; Phosphorylation; Thymidine; Thymidine Kinase; Virus Activation; Virus Replication | 1983 |
[Comparative studies of anti-herpes simplex virus compounds in vitro].
Topics: Antiviral Agents; Arabinonucleosides; Simplexvirus; Thymidine; Thymine Nucleotides; Vidarabine | 1982 |
Alterations in substrate specificity and physicochemical properties of deoxythymidine kinase of a drug-resistant herpes simplex virus type 1 mutant.
Topics: Arabinonucleosides; Blood; Bromodeoxyuridine; Deoxyuridine; Drug Resistance, Microbial; Enzyme Induction; Hot Temperature; Mutation; Phosphorylation; Simplexvirus; Substrate Specificity; Thymidine; Thymidine Kinase | 1983 |
Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin.
Topics: Antiviral Agents; Aphidicolin; Arabinonucleosides; Coformycin; Diterpenes; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Foscarnet; Pentostatin; Phosphonoacetic Acid; Simplexvirus; Thymidine; Thymidine Kinase; Vidarabine | 1983 |
Thymidine kinase (TK) induction after infection of TK-deficient rabbit cell mutants with bovine herpesvirus type 1 (BHV-1): isolation of TK- BHV-1 mutants.
Topics: Animals; Arabinonucleosides; Cell Line; Cytosol; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Herpesvirus 1, Bovine; Mutation; Phosphorylation; Rabbits; Thymidine; Thymidine Kinase; Trifluridine | 1983 |
Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on several parameters of Epstein-Barr virus infection.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Burkitt Lymphoma; Callitrichinae; Cell Line; Drug Evaluation, Preclinical; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Hybrid Cells; In Vitro Techniques; Thymidine; Virus Cultivation; Virus Replication | 1984 |
Thymine arabinoside (Ara-T) topical and iontophoretic application for herpes simplex virus type 1 and type 2 skin infections in hairless mice.
Topics: Administration, Topical; Animals; Antiviral Agents; Arabinonucleosides; Drug Evaluation, Preclinical; Herpes Simplex; Iontophoresis; Mice; Mice, Hairless; Thymidine | 1984 |
Arabinosylthymine: suppressor of hamster immunoglobulin M formation during primary immune response.
Topics: Animals; Antibodies, Bacterial; Antibody Formation; Arabinonucleosides; Brucella abortus; Cricetinae; Erythrocytes; Immunoglobulin M; Immunologic Memory; Immunosuppressive Agents; Thymidine | 1980 |
Ac2IDU, BVDU, and thymine arabinoside therapy in experimental herpes keratitis.
Topics: Animals; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Drug Evaluation, Preclinical; Idoxuridine; Keratitis, Dendritic; Male; Petrolatum; Rabbits; Sodium Chloride; Thymidine; Vidarabine | 1981 |
Deoxythymidine kinase metabolism in equine herpesvirus type 3 infected horse embryo dermal fibroblasts.
Topics: Animals; Arabinonucleosides; Cell Line; Enzyme Induction; Fibroblasts; Herpesviridae; Horses; Thymidine; Thymidine Kinase; Thymine Nucleotides | 1980 |
Effect of treatment with 1-beta-D-arabinofuranosylthymine of experimental encephalitis induced by herpes simplex virus in mice.
Topics: Animals; Antiviral Agents; Arabinonucleosides; Dose-Response Relationship, Drug; Encephalitis; Female; Herpes Simplex; Lethal Dose 50; Male; Mice; Thymidine; Time Factors | 1980 |
Suppression of infectious virus spread to the liver by foscarnet following lethal infection of acyclovir-resistant herpes simplex virus type 2 in mice.
Topics: Acyclovir; Animals; Arabinonucleosides; Brain; Chlorocebus aethiops; Drug Resistance, Microbial; Foscarnet; Hepatitis, Viral, Animal; Herpes Genitalis; Herpesvirus 2, Human; Humans; Injections, Intraperitoneal; Lethal Dose 50; Mice; Mice, Inbred C3H; Phosphonoacetic Acid; Thymidine; Vero Cells; Vidarabine | 1995 |
Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells.
Topics: Acyclovir; Adenoviruses, Human; Animals; Arabinonucleosides; Avian Sarcoma Viruses; Brain Neoplasms; Drug Resistance; Ganciclovir; Genes, Viral; Genetic Vectors; Glioma; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins; Simplexvirus; Thymidine; Thymidine Kinase; Transfection; Tumor Cells, Cultured | 1994 |
Channel catfish herpesvirus (CCV) encodes a functional thymidine kinase gene: elucidation of a point mutation that confers resistance to Ara-T.
Topics: Animals; Arabinonucleosides; Cell Line; Cloning, Molecular; Drug Resistance, Microbial; Genes, Viral; Herpesviridae; Ictaluridae; Molecular Sequence Data; Mutation; Repetitive Sequences, Nucleic Acid; Thymidine; Thymidine Kinase; Transfection; Viral Structural Proteins | 1994 |
In vitro sensitivity of macropodid herpesvirus 2 to selected anti-herpetic compounds.
Topics: Acyclovir; Animals; Antiviral Agents; Arabinonucleosides; Bromodeoxycytidine; Bromodeoxyuridine; Cell Line; Cytarabine; Deoxycytidine; Herpesviridae; Herpesviridae Infections; Idoxuridine; Macropodidae; Microbial Sensitivity Tests; Neutralization Tests; Thymidine; Trifluridine; Vidarabine | 1996 |
Synthesis and properties of alpha- and beta-oligodeoxynucleotides containing alpha- and beta-1-(2-O-methyl-D-arabino-furanosyl)thymine.
Topics: Arabinonucleosides; Isomerism; Magnetic Resonance Spectroscopy; Oligonucleotides; Thymidine | 1996 |
Superior cytotoxicity with ganciclovir compared with acyclovir and 1-beta-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing.
Topics: Acyclovir; Antineoplastic Agents; Apoptosis; Arabinonucleosides; Cell Cycle; DNA; Ganciclovir; Humans; Phosphorylation; Simplexvirus; Thymidine; Thymidine Kinase | 1998 |
Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antiviral Agents; Arabinonucleosides; Bromodeoxyuridine; Catalysis; Cell Division; Cell Nucleus; Cladribine; Cytarabine; Deoxycytidine; Drosophila melanogaster; Gemcitabine; Humans; Inhibitory Concentration 50; Kinetics; Osteosarcoma; Pancreatic Neoplasms; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Promoter Regions, Genetic; Retroviridae; Substrate Specificity; Thymidine; Thymidine Kinase; Transduction, Genetic; Tumor Cells, Cultured | 2000 |
2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Binding, Competitive; Humans; Kinetics; Mitochondria; Phosphorus Radioisotopes; Phosphorylation; Thymidine; Thymidine Kinase; Tritium | 2001 |
Ab initio vibrational calculations on ara-T molecule: application to analysis of IR and Raman spectra.
Topics: Antiviral Agents; Arabinonucleosides; Models, Molecular; Spectrophotometry, Infrared; Spectrum Analysis, Raman; Thymidine | 2001 |
Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol.
Topics: Amino Acid Sequence; Animals; Arabinonucleosides; Bromodeoxyuridine; Cell Death; Cell Nucleus; Cytosol; Drosophila melanogaster; Gene Expression; Genes, Insect; Genetic Therapy; Green Fluorescent Proteins; Humans; Luminescent Proteins; Osteosarcoma; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Recombinant Fusion Proteins; Retroviridae; Thymidine; Transduction, Genetic; Tumor Cells, Cultured | 2001 |
Lipid-mediated protein delivery of suicide nucleoside kinases.
Topics: Animals; Arabinonucleosides; Bone Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; CHO Cells; Cricetinae; Drosophila melanogaster; Endocytosis; Ganciclovir; Herpesvirus 1, Human; Humans; Liposomes; Osteosarcoma; Phosphatidylethanolamines; Phosphotransferases (Alcohol Group Acceptor); Recombinant Proteins; Thymidine; Thymidine Kinase | 2003 |
Synthesis and incorporation of an alpha-hexofuranosyl thymidine into oligodeoxynucleotides via its two exocyclic OH-groups.
Topics: Arabinonucleosides; Binding Sites; DNA, Complementary; Hydroxides; Molecular Structure; Oligodeoxyribonucleotides; Organophosphorus Compounds; RNA; Temperature; Thymidine | 2004 |
The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Arabinonucleosides; Chlorocebus aethiops; Enzyme Inhibitors; HeLa Cells; Humans; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Phosphotransferases; Spectrometry, Mass, Electrospray Ionization; Thymidine; Thymine; Vero Cells | 2006 |
Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts.
Topics: Arabinonucleosides; Biological Assay; Bromodeoxyuridine; Cell Extracts; Fibroblasts; Humans; Mitochondria; Phosphorylation; Protein Kinase Inhibitors; Substrate Specificity; Thymidine; Thymidine Kinase; Tumor Cells, Cultured | 2006 |
N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Topics: Adenosine Triphosphate; Animals; Antiviral Agents; Arabinonucleosides; Binding, Competitive; Cell Proliferation; Cell Survival; Drosophila melanogaster; Enzyme Inhibitors; Ganciclovir; Herpes Simplex; Herpesvirus 1, Human; Humans; Kinetics; Mitochondria; Models, Molecular; Molecular Conformation; Phosphorylation; Structure-Activity Relationship; Thymidine; Thymidine Kinase; Thymine | 2006 |
Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA.
Topics: Animals; Antineoplastic Agents; Arabinonucleosides; Cell Line, Tumor; Deoxycytidine Kinase; DNA, Mitochondrial; Humans; Phosphotransferases (Alcohol Group Acceptor); Thymidine; Thymidine Kinase | 2009 |
Synergistic therapeutic effect in gastric cancer cells produced by oncolytic adenovirus encoding Drosophila melanogaster deoxyribonucleoside kinase.
Topics: Adenoviridae; Animals; Arabinonucleosides; Cell Line; Cell Survival; Drosophila melanogaster; Drug Synergism; Female; Gene Order; Gene Transfer Techniques; Genetic Vectors; HEK293 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Oncolytic Viruses; Phosphotransferases (Alcohol Group Acceptor); Prodrugs; Stomach Neoplasms; Thymidine; Virus Replication; Xenograft Model Antitumor Assays | 2011 |
Efficacy of lentivirus‑mediated Drosophila melanogaster deoxyribonucleoside kinase combined with (E)‑5‑(2‑bromovinyl)‑2'‑deoxyuridine or 1‑β‑D‑arabinofuranosylthymine therapy in human keloid fibroblasts.
Topics: Adult; Animals; Apoptosis; Arabinonucleosides; Bromodeoxyuridine; Bystander Effect; Cell Proliferation; Combined Modality Therapy; Drosophila melanogaster; Enzyme Assays; Female; Fibroblasts; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; Humans; Insect Proteins; Keloid; Lentivirus; Male; Middle Aged; Phosphotransferases (Alcohol Group Acceptor); Primary Cell Culture; Thymidine; Transgenes | 2018 |