Page last updated: 2024-08-17

thymidine and stavudine

thymidine has been researched along with stavudine in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (12.12)	18.7374
1990's	11 (16.67)	18.2507
2000's	36 (54.55)	29.6817
2010's	11 (16.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Horwitz, JP; Kessel, D; Meltsner, BR; Palomino, E	1
Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H	1
Li, Y; Liotta, DC; Liu, L; Lutz, S; Soni, PB; Zhang, X	1
Eguchi, S; Hamano, Y; Matsuoka, Y; Minamoto, K; Watanabe, K	1
August, EM; Birks, EM; Prusoff, WH	1
August, EM; Marongiu, ME; Prusoff, WH	1
Lin, TS; Prusoff, WH; Schinazi, RF	1
August, EM; Brankovan, V; Ghazzouli, I; Hitchcock, MJ; Lin, TS; Mansuri, MM; Prusoff, WH; Sommadossi, JP; Starrett, JE; Sterzycki, RZ	1
Balzarini, J; De Clercq, E; Herdewijn, P	1
Schmahl, W; Stammberger, I; Tempel, K	1
Domin, BA; Mahony, WB; Zimmerman, TP	1
Baba, M; De Clercq, E; Desmyter, J; Herdewijn, P; Pauwels, R; Vandeputte, M	1
Hamamoto, Y; Matsuda, A; Matsui, T; Nakashima, H; Ueda, T; Yamamoto, N	1
Bawdon, RE; Kaul, S; Sobhi, S	1
Balzarini, J	1
Sinko, PJ; Waclawski, AP	1
Baba, M; Hashimoto, KI; Okamoto, M; Shigeta, S; Tsunoda, R	1
Back, DJ; Barry, MG; Hoggard, PG; Kewn, S; Khoo, SH	1
Segal, MB; Thomas, SA	1
Balzarini, J; Camarasa, MJ; Chamorro, C; De Clercq, E; Jimeno, ML; Tuñón, V; Velázquez, S	1
Boretto, J; Canard, B; Deville-Bonne, D; Guerreiro, C; Janin, J; Meyer, P; Sarfati, S; Schneider, B; Véron, M	1
Kong, F; Ning, J	1
Agut, H; Angleraud, F; Bonmarchand, M; Brun-Vezinet, F; Calvez, V; Coutellier, A; Delaugerre, C; Descamps, D; Izopet, J; Katlama, C; Matheron, S; Mouroux, M; Valantin, MA; Yvon-Groussin, A	1
Clark, R; Cohen, C; Cooley, T; Grosso, R; Gulick, R; Marlowe, SI; Mauney, J; Mulanovich, V; Santana, J; Schoellkopf, N; Squires, KE; Stevens, M; Tebas, P; Uffelman, K; Wright, D; Yangco, B	1
Bellos, N; Eron, JJ; Esinhart, J; Grosso, R; Jemsek, J; Murphy, RL; Parenti, DM; Peterson, D; Pottage, J; Rashbaum, BC; Schoellkopf, N; Sepulveda, G; Stevens, M; Swindells, S	1
Bower, M; Gazzard, BG; Mandalia, S; Matthews, GV; Moyle, GJ; Nelson, M	1
Aquaro, S; Balzarini, J; Bianchi, V; De Clercq, E; Knispel, T; Meier, C; Perno, CF; Rampazzo, C	1
Becker, SL; Fusco, GP; Fusco, JS; Graham, NM; Hansen, NI; Igboko, EF; Raffanti, SR; Slatko, GH	1
Becker, S; Fisher, R; Graham, N; Henry, K; Hernandez, J; Hirani, A; Liao, Q; Raffanti, S; Ross, L; Scarsella, A; St Clair, M	1
Ait-Khaled, M; Amphlett, G; Clotet, B; Katlama, C; Staszewski, S; Stone, C; Tisdale, M	1
Balzarini, J; De Clercq, E; Meier, C; Muus, U; Naesens, L; Renze, J	1
Balzarini, J; De Clercq, E; Ducho, C; Meier, C; Naesens, L	1
Pendergrass, S; Qazi, S; Richman, D; Uckun, FM; Venkatachalam, TK	1
Bates, M; Hellmann, NS; Hughes, MD; Katzenstein, DA; Shafer, RW; Shulman, NS; Whitcomb, JM; Winters, MA; Zolopa, AR	1
Carr, A; Cooper, DA; Hoy, J; Hudson, J; Law, M; Martin, A; Smith, DE	1
Konrad, M; Lavie, A; Meier, C; Monnerjahn, C; Ostermann, N; Segura-Peña, D; Veit, T	1
Balzarini, J; Barchi, JJ; Boyer, PL; Choi, Y; Comin, MJ; George, C; Hughes, SH; Jacobson, KA; Kim, HS; Marquez, VE; Mitsuya, H	1
Bölske, G; Carnrot, C; Eriksson, S; Wang, L; Wehelie, R	1
Calvez, V; Delaugerre, C; Katlama, C; Marcelin, AG; Simon, A; Viegas, P; Wirden, M	1
Ajana, F; Alcaraz, I; Bocket, L; Gerard, Y; Goffard, A; Mouton, Y; Viget, N; Wattré, P; Yazdanpanah, Y	1
Franco, S; Martínez, MA; Mas, A; Matamoros, T; Menéndez-Arias, L; Vázquez-Alvarez, BM	1
Calvo, KC; Koser, GF; Wang, X	1
Baba, M; Cheng, YC; Dutschman, GE; Haraguchi, K; Honma, Y; Itoh, Y; Nitanda, T; Takeda, S; Tanaka, H	1
Bates, M; Chappey, C; Clair, MS; Fisher, R; Lanier, ER; Parkin, N; Ross, L; Tisdale, M	1
Canard, B; Deval, J; Guerreiro, C; Matamoros, T; Menéndez-Arias, L; Mulard, L	1
Borderi, M	1
Kiseleva, IaIu; Pliasunova, OA; Pokrovskaia, NV; Pokrovskiĭ, AG	1
Haraguchi, K; Sumino, M; Tanaka, H	1
Haraguchi, K; Sumino, M; Takeda, S; Tanaka, H	1
Balzarini, J; Gisch, N; Meier, C	1
Côté, HC; Gadawski, I; Papp, E	1
Bélec, L; Charpentier, C; Karmochkine, M; Laureillard, D; Piketty, C; Si-Mohamed, A; Sodqi, M; Weiss, L	1
de la Fuente, M; Iza, N; Navarro, R; Palafox, MA	1
Portilla, J	1
Baba, M; Cheng, YC; Tanaka, H; Wang, X	1
Martínez, MA; Matamoros, T; Menéndez-Arias, L; Nevot, M	1
Alcolea Palafox, M; Iza, N	1
Laclair, DD; McKee, EE; Morris, GW	1
Curran, A; Ribera, E	1
McCann, KA; McKee, EE; Williams, DW	1
Bauerfeind, R; Behrens, GM; Binz, A; Leverkus, M; Panayotova-Dimitrova, D; Stankov, MV; Vondran, FW	1
Chaiwarith, R; Kotarathitithum, W; Nuntachit, N; Praparattanapan, J; Sirisanthana, T; Supparatpinyo, K	1
Flint, OP; Wang, F	1
Badia, R; Ballana, E; Clotet, B; Esté, JA; Martí, R; Pauls, E; Riveira-Muñoz, E; Ruiz, A; Terradas, G; Torres-Torronteras, J	1
Ba, S; Gottlieb, GS; Leong, SS; Oakes, MK; Parker, KM; Raugi, DN; Seydi, M; Smith, RA; Sow, PS; Wu, VH	1
Kitabatake, A; Koide, Y; Suzuki, T	1

Reviews

4 review(s) available for thymidine and stavudine

Article	Year
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives. Pharmacy world & science : PWS, 1994, Apr-15, Volume: 16, Issue:2 Topics: Animals; Antiviral Agents; Dideoxyadenosine; Dideoxynucleosides; Humans; Lamivudine; Purines; Pyrimidines; Retroviridae; Spiro Compounds; Stavudine; Thymidine; Uridine; Zalcitabine; Zidovudine	1994
[Use of thymidine-sparing regimens in first-line therapy and in switches from thymidine analogues]. Le infezioni in medicina, 2005, Volume: 13, Issue:3 Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Stavudine; Thymidine; Treatment Outcome; Zidovudine	2005
[Tenofovir as a strategy to avoid or limit adverse effects]. Enfermedades infecciosas y microbiologia clinica, 2008, Volume: 26 Suppl 8 Topics: Adenine; Anemia; Anti-HIV Agents; Antimetabolites; Clinical Trials as Topic; DNA, Mitochondrial; Double-Blind Method; Drug Therapy, Combination; Dyslipidemias; Glucose Metabolism Disorders; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Multicenter Studies as Topic; Organophosphonates; Prospective Studies; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zidovudine	2008
From old to new nucleoside reverse transcriptase inhibitors: changes in body fat composition, metabolic parameters and mitochondrial toxicity after the switch from thymidine analogs to tenofovir or abacavir. Expert opinion on drug safety, 2011, Volume: 10, Issue:3 Topics: Adenine; Adipose Tissue; Body Composition; Dideoxynucleosides; Drug Substitution; Humans; Metabolism; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zidovudine	2011

Trials

6 trial(s) available for thymidine and stavudine

Article	Year
A comparison of stavudine plus lamivudine versus zidovudine plus lamivudine in combination with indinavir in antiretroviral naive individuals with HIV infection: selection of thymidine analog regimen therapy (START I). AIDS (London, England), 2000, Jul-28, Volume: 14, Issue:11 Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; Follow-Up Studies; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lamivudine; Male; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Zidovudine	2000
A comparison of stavudine, didanosine and indinavir with zidovudine, lamivudine and indinavir for the initial treatment of HIV-1 infected individuals: selection of thymidine analog regimen therapy (START II). AIDS (London, England), 2000, Jul-28, Volume: 14, Issue:11 Topics: Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Didanosine; Dideoxynucleosides; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Lamivudine; Male; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Viral Load; Zidovudine	2000
Zidovudine and stavudine sequencing in HIV treatment planning: findings from the CHORUS HIV cohort. Journal of acquired immune deficiency syndromes (1999), 2001, Jan-01, Volume: 26, Issue:1 Topics: Adolescent; Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Homosexuality; Humans; Logistic Models; Longitudinal Studies; Male; Middle Aged; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; White People; Zidovudine	2001
Subtle decreases in stavudine phenotypic susceptibility predict poor virologic response to stavudine monotherapy in zidovudine-experienced patients. Journal of acquired immune deficiency syndromes (1999), 2002, Oct-01, Volume: 31, Issue:2 Topics: Adult; Anti-HIV Agents; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Phenotype; Predictive Value of Tests; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Time Factors; Treatment Outcome; Viral Load; Zidovudine	2002
Thymidine analogue withdrawal for lipoatrophic patients on protease-sparing therapy improves lipoatrophy but compromises antiviral control: the PIILR extension study. AIDS (London, England), 2002, Dec-06, Volume: 16, Issue:18 Topics: Anti-HIV Agents; HIV-Associated Lipodystrophy Syndrome; Humans; Male; Middle Aged; Stavudine; Substance Withdrawal Syndrome; Thymidine; Zidovudine	2002
Thymidine analogue mutations in antiretroviral-naive HIV-1 patients on triple therapy including either zidovudine or stavudine. The Journal of antimicrobial chemotherapy, 2004, Volume: 53, Issue:1 Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Resistance, Multiple, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation; Stavudine; Thymidine; Viral Load; Zidovudine	2004

Other Studies

56 other study(ies) available for thymidine and stavudine

Article	Year
Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders. Journal of medicinal chemistry, 1990, Volume: 33, Issue:1 Topics: AIDS Dementia Complex; Animals; Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Chemistry, Physical; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Kinetics; Molecular Structure; Phosphorylation; Pyrimidine Nucleosides; Rabbits; Stavudine; T-Lymphocytes; Thymidine Kinase; Thymus Gland; Zidovudine	1990
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents. Journal of medicinal chemistry, 1987, Volume: 30, Issue:8 Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication	1987
Synthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases. Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3 Topics: Animals; Drosophila melanogaster; Fluorescent Dyes; Nucleosides; Phosphotransferases (Alcohol Group Acceptor)	2010
Synthesis and reactivities of 2,2'-anhydro-1-(3'-deoxy-3'-iodo-5'-O-trityl- beta-D-arabinofuranosyl)thymine. Nucleic acids symposium series, 1991, Issue:25 Topics: Dideoxynucleosides; Molecular Structure; Stavudine; Thymidine	1991
3'-Deoxythymidin-2'-ene permeation of human lymphocyte H9 cells by nonfacilitated diffusion. Molecular pharmacology, 1991, Volume: 39, Issue:2 Topics: Antiviral Agents; Cell Membrane Permeability; Cells, Cultured; Dideoxynucleosides; Diffusion; Dipyridamole; Humans; Kinetics; Lymphocytes; Octanols; Solubility; Stavudine; Thioinosine; Thymidine; Time Factors; Water	1991
Effect of 3'-deoxythymidin-2'-ene (d4T) on nucleoside metabolism in H9 cells. Biochemical pharmacology, 1990, May-15, Volume: 39, Issue:10 Topics: Amino Acids; Cell Division; Cell Survival; Cells, Cultured; Cytidine; Deoxycytidine; Dideoxynucleosides; Humans; Nucleosides; Stavudine; Thymidine; Thymidine Kinase; Uridine	1990
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus. Biochemical pharmacology, 1987, Sep-01, Volume: 36, Issue:17 Topics: Antiviral Agents; Deoxycytidine; HIV; Humans; Monocytes; Retroviridae Proteins; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Virus Replication; Zidovudine	1987
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent. Journal of medicinal chemistry, 1989, Volume: 32, Issue:2 Topics: Antiviral Agents; Bone Marrow; Dideoxynucleosides; HIV; Stavudine; Thymidine; Zidovudine	1989
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. The Journal of biological chemistry, 1989, Apr-15, Volume: 264, Issue:11 Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Deoxycytidine; Deoxyribonucleotides; Dideoxynucleosides; Dose-Response Relationship, Drug; HIV; Humans; Mice; Phosphorylation; Sarcoma Viruses, Murine; Solubility; Stavudine; Thymidine; Zidovudine	1989
Scheduled and unscheduled DNA synthesis in chick embryo liver following X-irradiation and treatment with DNA repair inhibitors in vivo. International journal of radiation biology, 1989, Volume: 56, Issue:3 Topics: Animals; Autoradiography; Chick Embryo; Cytarabine; Dideoxynucleosides; DNA; DNA Repair; In Vitro Techniques; Liver; Stavudine; Thymidine; Tritium	1989
2',3'-Dideoxythymidine permeation of the human erythrocyte membrane by nonfacilitated diffusion. Biochemical and biophysical research communications, 1988, Aug-15, Volume: 154, Issue:3 Topics: Antiviral Agents; Biological Transport; Diffusion; Erythrocyte Membrane; Humans; Kinetics; Nucleosides; Stavudine; Thymidine; Tritium	1988
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. Biochemical and biophysical research communications, 1987, Jan-15, Volume: 142, Issue:1 Topics: Antigens, Viral; Antiviral Agents; Cell Line; Cell Survival; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Structure-Activity Relationship; Thymidine; Virus Replication; Zidovudine	1987
Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus. Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:6 Topics: Antigens, Viral; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Stavudine; Thymidine; Viral Plaque Assay; Virus Replication; Zalcitabine; Zidovudine	1987
The ex vivo transfer of the anti-HIV nucleoside compound d4T in the human placenta. Gynecologic and obstetric investigation, 1994, Volume: 38, Issue:1 Topics: Diffusion; Dipyridamole; Female; Fetal Blood; Gestational Age; Humans; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy; Stavudine; Thymidine; Zidovudine	1994
Oral absorption of anti-acquired immune deficiency syndrome nucleoside analogues. 2. Carrier-mediated intestinal transport of stavudine in rat and rabbit preparations. Journal of pharmaceutical sciences, 1996, Volume: 85, Issue:5 Topics: Administration, Oral; Animals; Antiviral Agents; Biological Availability; Biological Transport; Drug Carriers; Drug Stability; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Microvilli; Rabbits; Rats; Rats, Sprague-Dawley; Stavudine; Thymidine	1996
Stavudine selectively induces apoptosis in HIV type 1-infected cells. AIDS research and human retroviruses, 1997, Jan-20, Volume: 13, Issue:2 Topics: Anti-HIV Agents; Apoptosis; Cell Line; Didanosine; DNA Fragmentation; Down-Regulation; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reverse Transcriptase Inhibitors; Stavudine; T-Lymphocytes; Thymidine; Zalcitabine; Zidovudine	1997
Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:6 Topics: Anti-HIV Agents; Cells, Cultured; Drug Interactions; Humans; Leukemia, Monocytic, Acute; Leukocytes, Mononuclear; Phosphorylation; Phytohemagglutinins; Stavudine; Stimulation, Chemical; Thymidine; Zidovudine	1997
The transport of the anti-HIV drug, 2',3'-didehydro-3'-deoxythymidine (D4T), across the blood-brain and blood-cerebrospinal fluid barriers. British journal of pharmacology, 1998, Volume: 125, Issue:1 Topics: Analysis of Variance; Animals; Anti-HIV Agents; Biological Transport; Blood-Brain Barrier; Brain; Guinea Pigs; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine	1998
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Anti-HIV Agents; Cell Line; Dimerization; HIV-1; HIV-2; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Fast Atom Bombardment; Spiro Compounds; Stavudine; Thymidine; Uridine; Zidovudine	1999
Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase. The EMBO journal, 2000, Jul-17, Volume: 19, Issue:14 Topics: Anti-HIV Agents; Boron Compounds; Crystallography, X-Ray; DNA Repair; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Models, Molecular; Molecular Conformation; Nucleoside-Diphosphate Kinase; Protein Binding; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Thymidine; Transcription, Genetic; Zidovudine	2000
A facile synthesis of 1-(5'-O-acetyl-3'-O-benzyl-beta-D-xylofuranosyl)thymidine: a potentially viable intermediate for the preparation of the anti-AIDS drugs, AZT and D4T. Carbohydrate research, 2000, Jun-16, Volume: 326, Issue:3 Topics: Anti-HIV Agents; Stavudine; Thymidine; Zidovudine	2000
[Conditions of "thymidine analog mutations" (TAMs) in naive patients treated with different combinations of d4T]. Pathologie-biologie, 2000, Volume: 48, Issue:5 Topics: Anti-HIV Agents; Drug Resistance; Humans; Lamivudine; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine	2000
Absence of association between individual thymidine analogues or nonnucleoside analogues and lipid abnormalities in HIV-1-infected persons on initial therapy. Journal of acquired immune deficiency syndromes (1999), 2000, Aug-01, Volume: 24, Issue:4 Topics: Adult; Alkynes; Anti-HIV Agents; Arteriosclerosis; Benzoxazines; Cholesterol; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lipids; Male; Nevirapine; Oxazines; Risk Factors; Stavudine; Thymidine; Triglycerides; Zidovudine	2000
Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP. Molecular pharmacology, 2000, Volume: 58, Issue:5 Topics: 5'-Nucleotidase; Anti-HIV Agents; Culture Media; Dideoxynucleotides; Half-Life; Humans; Hydrogen-Ion Concentration; Leukocytes, Mononuclear; Macrophages; Monocytes; Stavudine; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Thymine Nucleotides; Time Factors; Tritium; Tumor Cells, Cultured; Zidovudine	2000
Thymidine analog and multinucleoside resistance mutations are associated with decreased phenotypic susceptibility to stavudine in HIV type 1 isolated from zidovudine-naive patients experiencing viremia on stavudine-containing regimens. AIDS research and human retroviruses, 2001, Aug-10, Volume: 17, Issue:12 Topics: Anti-HIV Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; HIV Infections; HIV Protease; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Molecular Sequence Data; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Viremia; Zidovudine	2001
M184V is associated with a low incidence of thymidine analogue mutations and low phenotypic resistance to zidovudine and stavudine. AIDS (London, England), 2002, Aug-16, Volume: 16, Issue:12 Topics: Drug Resistance, Microbial; Genotype; HIV Infections; HIV-1; Humans; Mutation; Phenotype; Retrospective Studies; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Viral Load; Zidovudine	2002
Comparative study of bis(benzyl)phosphate triesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and cyclosal-d4TMP--hydrolysis, mechanistic insights and anti-HIV activity. Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:2 Topics: Anti-HIV Agents; Dideoxynucleotides; Esters; HIV-1; HIV-2; Humans; Hydrolysis; Molecular Structure; Stavudine; Structure-Activity Relationship; Thymidine; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured	2002
Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity. Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:2 Topics: Anti-HIV Agents; Dideoxynucleotides; Drug Stability; Esters; Half-Life; HIV-1; HIV-2; Humans; Hydrolysis; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Stavudine; Structure-Activity Relationship; Thymidine; Thymidine Kinase; Thymine Nucleotides; Tumor Cells, Cultured	2002
Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:11 Topics: Anti-HIV Agents; Dideoxynucleotides; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Nucleosides; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Thymidine; Thymidine Monophosphate; Zidovudine	2002
Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. Biochemistry, 2003, Mar-11, Volume: 42, Issue:9 Topics: Anti-HIV Agents; Crystallography, X-Ray; Dideoxynucleotides; Drug Design; Humans; Kinetics; Macromolecular Substances; Nucleoside-Phosphate Kinase; Prodrugs; Protein Conformation; Stavudine; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Monophosphate; Thymine Nucleotides	2003
A conformationally locked analogue of the anti-HIV agent stavudine. An important correlation between pseudorotation and maximum amplitude. Journal of medicinal chemistry, 2003, Jul-17, Volume: 46, Issue:15 Topics: Animals; Anti-HIV Agents; Bridged Bicyclo Compounds; Cell Line; Crystallography, X-Ray; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Lymphocytes; Molecular Conformation; Molecular Mimicry; Reverse Transcriptase Inhibitors; Stavudine; Stereoisomerism; Structure-Activity Relationship; Thymidine	2003
Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth. Molecular microbiology, 2003, Volume: 50, Issue:3 Topics: Amino Acid Sequence; Cell Division; Cloning, Molecular; Deoxyuridine; Escherichia coli; Feedback, Physiological; Molecular Sequence Data; Molecular Weight; Mycoplasma pneumoniae; Nucleosides; Phosphates; Pyrimidine Nucleosides; Recombinant Proteins; Sequence Homology, Amino Acid; Stavudine; Substrate Specificity; Tetrahydrouridine; Thymidine; Thymidine Kinase; Thymine Nucleotides; Ureaplasma urealyticum; Zidovudine	2003
Thymidine analogue reverse transcriptase inhibitors resistance mutations profiles and association to other nucleoside reverse transcriptase inhibitors resistance mutations observed in the context of virological failure. Journal of medical virology, 2004, Volume: 72, Issue:1 Topics: Anti-HIV Agents; Base Sequence; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thymidine; Treatment Failure; Viral Load; Zidovudine	2004
Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNA prim The Journal of biological chemistry, 2004, Jun-04, Volume: 279, Issue:23 Topics: Adenosine Triphosphate; Amino Acid Sequence; Base Sequence; Codon; DNA; DNA Primers; Drug Resistance, Viral; Gene Deletion; HIV Reverse Transcriptase; Kinetics; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Phenotype; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Sequence Homology, Amino Acid; Stavudine; Thymidine; Time Factors; Tyrosine; Zidovudine	2004
Bis-ketol nucleoside triesters as prodrugs of the antiviral nucleoside triphosphate analogues of 3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:3 Topics: Anti-HIV Agents; Cell Line; Esters; HIV; Humans; Molecular Structure; Nucleosides; Prodrugs; Stavudine; Thymidine	2004
Synthesis and anti-HIV activity of 4'-cyano-2',3'-didehydro-3'-deoxythymidine. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:4 Topics: Animals; Anti-HIV Agents; HIV Infections; HIV-1; Humans; Stavudine; Thymidine	2004
Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance. AIDS (London, England), 2004, Aug-20, Volume: 18, Issue:12 Topics: Adenine; Algorithms; Anti-HIV Agents; Databases, Genetic; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV; HIV Infections; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zalcitabine; Zidovudine	2004
Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues. Journal of molecular biology, 2005, Jun-10, Volume: 349, Issue:3 Topics: Adenosine Triphosphate; Boron Compounds; Dideoxynucleotides; Drug Resistance, Multiple, Viral; HIV-1; Humans; Kinetics; Mutation; Phosphorylation; RNA-Directed DNA Polymerase; Stavudine; Thymidine; Thymine Nucleotides; Time Factors; Zidovudine	2005
[In vitro selection and phenotyping of HIV-1 mutants resistant to azidothymidine and didanosine]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2005, Volume: 50, Issue:5-6 Topics: Didanosine; Drug Resistance, Viral; HIV-1; Mutation; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zidovudine	2005
Nucleophilic substitution at the 4'-position of nucleosides: new access to a promising anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine. The Journal of organic chemistry, 2006, Jun-09, Volume: 71, Issue:12 Topics: Anti-HIV Agents; Indicators and Reagents; Nucleosides; Stavudine; Structure-Activity Relationship; Thymidine	2006
An alternative method suitable for a large scale synthesis of 4'-ethynyl-2',3'-didehydro-3'-deoxythymidine. Nucleic acids symposium series (2004), 2004, Issue:48 Topics: Combinatorial Chemistry Techniques; Stavudine; Thymidine	2004
Enzymatically activated cycloSal-d4T-monophosphates: The third generation of cycloSal-pronucleotides. Journal of medicinal chemistry, 2007, Apr-05, Volume: 50, Issue:7 Topics: Anti-HIV Agents; Cell Line; Dideoxynucleotides; Humans; Hydrolysis; Organophosphates; Stavudine; Structure-Activity Relationship; Thymidine; Thymine Nucleotides	2007
Longitudinal effects of thymidine analogues on mtDNA, mtRNA and multidrug resistance (MDR-1) induction in cultured cells. The Journal of antimicrobial chemotherapy, 2008, Volume: 61, Issue:5 Topics: Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; DNA, Mitochondrial; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; K562 Cells; RNA; RNA, Mitochondrial; Stavudine; Thymidine; Time Factors; Zidovudine	2008
Foscarnet salvage therapy efficacy is associated with the presence of thymidine-associated mutations (TAMs) in HIV-infected patients. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2008, Volume: 43, Issue:2 Topics: Adult; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Foscarnet; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Mutation; Reverse Transcriptase Inhibitors; Salvage Therapy; Stavudine; Thymidine; Treatment Outcome; Zidovudine	2008
Simulation of the first hydration shell of nucleosides D4T and thymidine: structures obtained using MP2 and DFT methods. The journal of physical chemistry. B, 2009, Feb-26, Volume: 113, Issue:8 Topics: Anti-HIV Agents; Hydrogen Bonding; Nucleic Acid Conformation; Quantum Theory; Stavudine; Thermodynamics; Thymidine; Water	2009
Retention of metabolites of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel anti-human immunodeficiency virus type 1 thymidine analog, in cells. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:8 Topics: Anti-HIV Agents; Biological Transport; Cell Line; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dipyridamole; Humans; Multidrug Resistance-Associated Proteins; Phosphodiesterase Inhibitors; Phosphorylation; Stavudine; Thymidine; Zidovudine	2009
Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination. The Journal of biological chemistry, 2009, Nov-20, Volume: 284, Issue:47 Topics: Acyclovir; Adenosine Triphosphate; Anti-HIV Agents; DNA Mutational Analysis; DNA Primers; Drug Resistance, Multiple; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Stavudine; Thymidine; Valine; Zidovudine	2009
Tautomerism of the natural thymidine nucleoside and the antiviral analogue D4T. Structure and influence of an aqueous environment using MP2 and DFT methods. Physical chemistry chemical physics : PCCP, 2010, Jan-28, Volume: 12, Issue:4 Topics: Antiviral Agents; Hydrogen Bonding; Quantum Theory; Stavudine; Thermodynamics; Thymidine; Water	2010
Pyrimidine deoxynucleoside and nucleoside reverse transcriptase inhibitor metabolism in the perfused heart and isolated mitochondria. Antiviral therapy, 2010, Volume: 15, Issue:4 Topics: Animals; Anti-HIV Agents; Deoxycytidine; Male; Mitochondria, Heart; Myocardium; Nucleosides; Perfusion; Phosphorylation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Stavudine; Thymidine; Zalcitabine; Zidovudine	2010
Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria. Journal of neurochemistry, 2012, Volume: 122, Issue:1 Topics: Animals; Brain; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Kinetics; Male; Mitochondria; Nucleotidases; Phosphorylation; Pyrimidine Nucleosides; Rats; Rats, Sprague-Dawley; Stavudine; Thymidine; Time Factors; Tritium; Zidovudine	2012
Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation. AIDS (London, England), 2012, Oct-23, Volume: 26, Issue:16 Topics: Anti-HIV Agents; Autophagy; Blotting, Western; Cells, Cultured; DNA, Mitochondrial; Fatty Liver; Female; Flow Cytometry; Hep G2 Cells; HIV Infections; Humans; Lipid Metabolism; Male; Microscopy, Electron; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Stavudine; Thymidine; Zidovudine	2012
Resistance-associated mutations after initial antiretroviral treatment failure in a large cohort of patients infected with HIV-1 subtype CRF01_AE. Current HIV research, 2012, Volume: 10, Issue:8 Topics: Adult; Aged; Anti-HIV Agents; Cohort Studies; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Thailand; Thymidine; Treatment Failure; Zidovudine	2012
BMS-986001, an HIV nucleoside reverse transcriptase inhibitor, does not degrade mitochondrial DNA in long-term primary cultures of cells isolated from human kidney, muscle, and adipose tissue. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:12 Topics: Adenine; Adipocytes; DNA Fragmentation; DNA, Mitochondrial; Epithelial Cells; Humans; Kidney Tubules, Proximal; Mitochondria; Muscle Fibers, Skeletal; Organophosphonates; Primary Cell Culture; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Tenofovir; Thymidine	2013
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8 Topics: CD4-Positive T-Lymphocytes; Gene Expression; HIV Reverse Transcriptase; HIV-2; Host-Pathogen Interactions; Humans; Jurkat Cells; Macrophages; Monomeric GTP-Binding Proteins; Primary Cell Culture; Reverse Transcriptase Inhibitors; SAM Domain and HD Domain-Containing Protein 1; Stavudine; Thymidine; Viral Regulatory and Accessory Proteins; Virus Replication; Zidovudine	2014
The Nucleoside Analog BMS-986001 Shows Greater In Vitro Activity against HIV-2 than against HIV-1. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12 Topics: Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Reverse Transcriptase Inhibitors; Stavudine; Thymidine	2015
Reaction of Thymidine with Hypobromous Acid in Phosphate Buffer. Chemical & pharmaceutical bulletin, 2016, Volume: 64, Issue:8 Topics: Bromates; Buffers; Molecular Structure; Phosphates; Stavudine; Thymidine	2016