thymidine has been researched along with raltitrexed in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gangjee, A; Jain, HD; Kisliuk, RL; McGuire, JJ | 1 |
| Gangjee, A; Kisliuk, RL; Lin, X; McGuire, JJ | 1 |
| Arredondo, MA; Guimaraes, MA; Rustum, YM; Yin, MB; Zhang, ZG | 1 |
| Cao, S; Rustum, YM; Yin, MB | 1 |
| Rathod, PK; Reshmi, S | 1 |
| Lehman, NL; Moran, RG; Smith, SG | 1 |
| Keyomarsi, K; Molnar, G; Pardee, AB; Samet, J | 1 |
| Hickman, JA; Jackman, AL; Potten, CS; Pritchard, DM; Watson, AJ | 1 |
| Harris, AL; Patterson, AV; Stratford, IJ; Talbot, DC | 1 |
| Frank, C; Guo, B; Panadero, A; Rustum, YM; Slocum, HK; Wrzosek, C; Yin, MB | 1 |
| Cao, S; McGuire, JJ; Rustum, YM | 1 |
| Aherne, GW; Benstead, J; Clarke, SJ; Farrugia, DC; Jackman, AL; Pritchard, DM | 1 |
| Danenberg, PV; Lehman, NL | 1 |
| Genestier, L; Izeradjene, K; Revillard, JP | 1 |
| Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D | 1 |
| Faessel, HM; Greco, WR; Rustum, YM; Slocum, HK | 1 |
| Banerjee, D; Bertino, JR; Li, WW; Magro, PG; Russo, AJ | 1 |
| Antony, S; Gmeiner, WH; Kohlhagen, G; Liao, ZY; Pommier, Y; Sordet, O; Zhang, HL | 1 |
| Boddy, AV; Graham-Cole, CL; Hesp, R; Melton, RG; Newell, DR; Taylor, GA; Thomas, HD | 1 |
| Cassidy, J; Collie-Duguid, ES; McLeod, HL; Wang, W | 1 |
| Boddy, AV; Heer, R; Karran, P; Newell, DR; O'Toole, K; Pridgeon, SW; Robinson, M; Taylor, GA; Xu, YZ | 1 |
| Ghosh, D; McMahon, MA; Seiple, L; Siliciano, RF; Spivak, AM; Stivers, JT; Weil, AF; Zhou, Y | 1 |
22 other study(ies) available for thymidine and raltitrexed
| Article | Year |
|---|---|
Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Pyrimidines; Structure-Activity Relationship; Thymidylate Synthase | 2004 |
Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofol
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Escherichia coli; Folic Acid Antagonists; Glutamates; Humans; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Toxoplasma | 2005 |
Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor.
Topics: Cell Division; Cell Line; DNA; DNA Damage; DNA, Single-Stranded; Fluorouracil; Formyltetrahydrofolates; Methotrexate; Quinazolines; Rhodamines; Thiophenes; Thymidine; Thymidylate Synthase; Time Factors | 1992 |
Modulation of target enzyme associated with the action of antifolates.
Topics: Antimetabolites, Antineoplastic; Carcinoma; Dose-Response Relationship, Drug; Drug Interactions; Evaluation Studies as Topic; Humans; Intestinal Neoplasms; Leucovorin; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.
Topics: Animals; Antimalarials; Cell Division; Erythrocytes; Folic Acid Antagonists; HeLa Cells; Humans; In Vitro Techniques; Mice; Plasmodium falciparum; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
Topics: Acyltransferases; Antineoplastic Agents; Cell Division; Cell Survival; Colonic Neoplasms; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Hypoxanthines; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme.
Topics: Cell Cycle; Cell Division; Cells, Cultured; Cycloheximide; Enzyme Stability; Humans; Protein Biosynthesis; Quinazolines; RNA, Messenger; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation.
Topics: Animals; Apoptosis; Colon; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Histocytochemistry; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Male; Mice; Mice, Inbred Strains; Quinazolines; RNA; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Suppressor Protein p53; Uridine | 1997 |
Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Culture Media, Conditioned; Dose-Response Relationship, Drug; Female; Humans; Quinazolines; Thiophenes; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Time Factors; Transfection; Tumor Cells, Cultured | 1998 |
Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex.
Topics: Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; DNA Fragmentation; DNA-Binding Proteins; DNA, Neoplasm; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Activation; Enzyme Inhibitors; Growth Inhibitors; Humans; Macromolecular Substances; Protein Serine-Threonine Kinases; Quinazolines; Retinoblastoma-Binding Protein 1; Thiophenes; Thymidine; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured | 1999 |
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity.
Topics: Animals; Antimetabolites, Antineoplastic; Deoxyuridine; Diarrhea; Digestive System; Dose-Response Relationship, Drug; Folic Acid; Intestinal Mucosa; Intestine, Large; Intestine, Small; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Weight Loss | 2000 |
Modulation of RTX cytotoxicity by thymidine and dipyridamole in vitro: implications for chemotherapy.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Genes, p53; Humans; Phosphodiesterase Inhibitors; Quinazolines; Thiophenes; Thymidine; Tumor Cells, Cultured | 2000 |
Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells.
Topics: Animals; CD8-Positive T-Lymphocytes; Clonal Deletion; Enterotoxins; Fas Ligand Protein; fas Receptor; Folic Acid Antagonists; Growth Inhibitors; Injections, Intraperitoneal; Injections, Intravenous; Ligands; Lymphocyte Activation; Lymphocyte Depletion; Membrane Glycoproteins; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Nucleic Acid Synthesis Inhibitors; Quinazolines; Staphylococcus aureus; Superantigens; T-Lymphocyte Subsets; Thiophenes; Thymidine; Thymidylate Synthase | 2001 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase | 2001 |
Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cecal Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Folic Acid; Glutamates; Hematinics; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Ileal Neoplasms; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 2003 |
p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
Topics: Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Stability; Fibrosarcoma; Folic Acid Antagonists; Humans; Methotrexate; Neoplastic Stem Cells; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53 | 2004 |
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Death; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; DNA, Single-Stranded; Drug Screening Assays, Antitumor; Fluorodeoxyuridylate; Fluorouracil; Leukemia P388; Mice; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Topoisomerase I Inhibitors | 2005 |
An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Cell Line, Tumor; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; HT29 Cells; Humans; Immunoglobulin Fab Fragments; Injections, Intravenous; Mice; Mice, Nude; Quinazolines; Reproducibility of Results; Thiophenes; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Xenograft Model Antitumor Assays | 2007 |
Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Fluorouracil; Humans; NF-kappa B; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2007 |
Thiothymidine combined with UVA as a potential novel therapy for bladder cancer.
Topics: Animals; Apoptosis; Cell Line, Tumor; DNA Damage; Female; Humans; Quinazolines; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Thiophenes; Thymidine; Ultraviolet Therapy; Urinary Bladder Neoplasms | 2011 |
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.
Topics: Anti-HIV Agents; Base Sequence; CD4-Positive T-Lymphocytes; Deoxyuracil Nucleotides; DNA Glycosylases; DNA, Viral; Enzyme Inhibitors; Gene Knockdown Techniques; HIV-1; Host-Pathogen Interactions; HT29 Cells; Humans; Immunity, Innate; Macrophages; Models, Biological; Mutation; Quinazolines; Reverse Transcription; Thiophenes; Thymidine; Thymidylate Synthase; Virion; Virus Integration | 2013 |