Compounds > thymidine
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thymidine and quinazolines

thymidine has been researched along with quinazolines in 57 studies

Research

Studies (57)

TimeframeStudies, this research(%)All Research%
pre-199014 (24.56)18.7374
1990's16 (28.07)18.2507
2000's19 (33.33)29.6817
2010's8 (14.04)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arredondo, MA; Guimaraes, MA; Rustum, YM; Yin, MB; Zhang, ZG1
Grainger, DJ; Hesketh, TR; Metcalfe, JC; Weissberg, PL1
Aherne, GW; Curtin, NJ; Harris, AL1
Bunni, M; Chou, TC; Galivan, J; Johnson, TB; Nair, MG; Priest, D; Rhee, MS1
Curtin, NJ; Harris, AL; Newell, DR1
Bertino, JR; Sobrero, AF1
Branda, RF; Carney, JK; McCormack, JJ; Moore, AL; Perlmutter, CA1
Galivan, J; Nimec, Z; Rhee, M1
Bassendine, MF; Curtin, NJ; Harris, AL; James, OF1
Bertino, JR; Handschumacher, RE; Sobrero, AF1
Boiocchi, M; Broggini, M; D'Incalci, M; Erba, E; Lorico, A; Rappa, G; Toffoli, G1
Curtin, NJ; Harris, AL1
Carlin, SC; Friedkin, M; Rosenberg, RN; VandeVenter, L1
Dewey, VC; Kidder, GW1
Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ1
Calvert, AH; Harrap, KR; Jackman, AL; Taylor, GA1
Ahmed, JS; Rehbein, G; Zweygarth, E1
Cao, S; Rustum, YM; Yin, MB1
Banks, SD; Barrett, LL; Dickerson, S; Pendergast, W; Smith, GK; Waters, KA1
Rathod, PK; Reshmi, S1
Lehman, NL; Moran, RG; Smith, SG1
Keyomarsi, K; Molnar, G; Pardee, AB; Samet, J1
Bridges, AJ; Denny, WA; Fry, DW; Kraker, AJ; McMichael, A; Nelson, J; Palmer, BD; Rewcastle, GW; Showalter, HD; Sun, L1
Hickman, JA; Jackman, AL; Potten, CS; Pritchard, DM; Watson, AJ1
Dobson, JG; Ethier, MF1
Harris, AL; Patterson, AV; Stratford, IJ; Talbot, DC1
Frank, C; Guo, B; Panadero, A; Rustum, YM; Slocum, HK; Wrzosek, C; Yin, MB1
Cao, S; McGuire, JJ; Rustum, YM1
Bowman, KJ; Calvert, AH; Curtin, NJ; Golding, BT; Griffin, RJ; Huang, B; Loughlin, PJ; Newell, DR; Turner, RN1
Canestrari, JG; McGuire, JJ; Nagel, GS1
Aherne, GW; Benstead, J; Clarke, SJ; Farrugia, DC; Jackman, AL; Pritchard, DM1
Danenberg, PV; Lehman, NL1
Jiang, L; Lee, PC; Rathod, PK; White, J1
Ahn, HS; Boykow, G; Foster, C; Graziano, M; Manna, M; Stamford, A1
Genestier, L; Izeradjene, K; Revillard, JP1
Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D1
Aboagye, E; Boddy, AV; Calvert, AH; Gunn, RN; Hughes, AN; Newell, DR; Osman, S; Price, PM; Rafi, I; Taylor, GA; Wells, P1
Faessel, HM; Greco, WR; Rustum, YM; Slocum, HK1
Rozengurt, E; Santiskulvong, C; Sinnett-Smith, J1
Banerjee, D; Bertino, JR; Li, WW; Magro, PG; Russo, AJ1
Antony, S; Gmeiner, WH; Kohlhagen, G; Liao, ZY; Pommier, Y; Sordet, O; Zhang, HL1
Donson, AM; Foreman, NK; Gore, L; Heideman, R; Straessle, J; Wells, D1
Erlichman, C; Goble, JM; James, CD; Lamont, JD; Mladek, AC; Rao, RD; Sarkaria, JN1
Burgess, AW; Doherty, MM; Ellis, AG; Johns, TG; Levitzki, A; McLachlan, G; Murphy, R; Nerrie, M; Nice, EC; Scott, AM; Vitali, A; Walker, F; Webster, LK; Weinstock, J1
Aboagye, E; Pillai, RG; Price, P; Yau, K1
Boddy, AV; Graham-Cole, CL; Hesp, R; Melton, RG; Newell, DR; Taylor, GA; Thomas, HD1
Cassidy, J; Collie-Duguid, ES; McLeod, HL; Wang, W1
Bandobashi, K; Ikezoe, T; Koeffler, HP; Komatsu, N; Kuwayama, Y; Nishioka, C; Taguchi, H; Taniguchi, A; Tasaka, T; Togitani, K; Yang, J; Yokoyama, A1
Im, KC; Kim, SW; Lee, DH; Lee, JS; Moon, DH; Oh, SJ; Ryu, JS; Sohn, HJ; Suh, C; Yang, YJ1
Boarder, MR; Cheng, Z; Dixon, CJ; Hall, JF; Luo, Y; Taylor, E1
Benz, MR; Bockisch, A; Czernin, J; Damoiseaux, RD; Hartung, V; Hildebrandt, IJ; Laing, RE; Phelps, ME; Walter, MA; Weber, WA1
Banerjee, D; Bertino, JR; Blasberg, RG; Cai, S; de Stanchina, E; Kochetkov, T; Moroz, MA; Nair, J; Schwartz, GK; Serganova, I; Shamis, M; Wu, J1
Amler, LC; Charu, V; Fine, BM; Gitlitz, BJ; Hicks, RJ; Hughes, BG; Macfarlane, D; Mileshkin, L; Mitchell, PL; Pirzkall, A; Solomon, B; Yu, W1
Boddy, AV; Heer, R; Karran, P; Newell, DR; O'Toole, K; Pridgeon, SW; Robinson, M; Taylor, GA; Xu, YZ1
Ahn, JH; Kim, EJ; Kim, SW; Kim, SY; Lee, HJ; Lee, SJ; Moon, DH; Oh, SJ; Ryu, JS1
Ghosh, D; McMahon, MA; Seiple, L; Siliciano, RF; Spivak, AM; Stivers, JT; Weil, AF; Zhou, Y1
Amzel, LM; Bhat, S; Chen, X; Cheng, YL; Crews, P; Gabelli, SB; Liu, JO; Ma, D; Meyers, DJ; Miller, MS; Nacev, BA; Shim, JS; Tenney, K; Zhang, F1

Trials

1 trial(s) available for thymidine and quinazolines

ArticleYear
Changes in 18F-fluorodeoxyglucose and 18F-fluorodeoxythymidine positron emission tomography imaging in patients with non-small cell lung cancer treated with erlotinib.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, May-15, Volume: 17, Issue:10

    Topics: Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Disease Progression; Erlotinib Hydrochloride; Female; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Positron-Emission Tomography; Quinazolines; Radiopharmaceuticals; Survival Analysis; Thymidine

2011

Other Studies

56 other study(ies) available for thymidine and quinazolines

ArticleYear
Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor.
    Cancer research, 1992, Nov-01, Volume: 52, Issue:21

    Topics: Cell Division; Cell Line; DNA; DNA Damage; DNA, Single-Stranded; Fluorouracil; Formyltetrahydrofolates; Methotrexate; Quinazolines; Rhodamines; Thiophenes; Thymidine; Thymidylate Synthase; Time Factors

1992
Hexamethylenebisacetamide selectively inhibits the proliferation of human and rat vascular smooth-muscle cells.
    The Biochemical journal, 1992, Apr-15, Volume: 283 ( Pt 2)

    Topics: Acetamides; Animals; Cell Division; Cells, Cultured; Coumarins; DNA Replication; Endothelium, Vascular; Fibroblasts; Hematinics; Humans; Kinetics; Muscle, Smooth, Vascular; Quinazolines; Quinazolinones; Rats; Thymidine

1992
Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.
    Cancer research, 1991, May-01, Volume: 51, Issue:9

    Topics: Cell Division; Cell Survival; Deoxyuracil Nucleotides; Dipyridamole; DNA Damage; Drug Synergism; Folic Acid; Humans; Lung Neoplasms; Quinazolines; Thymidine; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured

1991
The enhancement of the activity of 10-propargyl-5,8-dideazafolate and 5,10-dideazatetrahydrofolate by inhibitors of dihydrofolate reductase.
    Advances in enzyme regulation, 1989, Volume: 28

    Topics: Animals; Cell Line; Cell Survival; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Liver Neoplasms, Experimental; Quinazolines; Rats; Tetrahydrofolates; Thymidine; Tumor Cells, Cultured

1989
Modulation of dipyridamole action by alpha 1 acid glycoprotein. Reduced potentiation of quinazoline antifolate (CB3717) cytotoxicity by dipyridamole.
    Biochemical pharmacology, 1989, Oct-01, Volume: 38, Issue:19

    Topics: Biological Transport; Cell Division; Dipyridamole; Drug Synergism; Folic Acid; Folic Acid Antagonists; Humans; Nucleosides; Orosomucoid; Quinazolines; Thymidine; Tumor Cells, Cultured

1989
Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
    International journal of cell cloning, 1986, Volume: 4, Issue:1

    Topics: Adenocarcinoma; Animals; Cattle; Cell Adhesion; Colonic Neoplasms; Colony-Forming Units Assay; Culture Media; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Methotrexate; Neoplastic Stem Cells; Quinazolines; Thymidine; Trimetrexate

1986
Inhibition of lymphocyte nucleic acid metabolism and antibody production by trimetrexate.
    Biochemical pharmacology, 1987, May-15, Volume: 36, Issue:10

    Topics: Antibody Formation; Deoxyuridine; DNA; Humans; Interphase; Lymphocytes; Methotrexate; Nucleic Acids; Quinazolines; Thymidine; Trimetrexate

1987
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
    Cancer research, 1987, Oct-15, Volume: 47, Issue:20

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate

1987
Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717.
    British journal of cancer, 1986, Volume: 53, Issue:3

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Humans; In Vitro Techniques; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thymidine

1986
Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine.
    Cancer research, 1985, Volume: 45, Issue:7

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Cell Line; Colonic Neoplasms; Drug Resistance; Floxuridine; Humans; Hypoxanthine; Hypoxanthines; Methotrexate; Nucleosides; Quinazolines; Thymidine

1985
Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid.
    Cancer research, 1988, Apr-15, Volume: 48, Issue:8

    Topics: Cell Cycle; Cell Survival; Cycloheximide; DNA; DNA Damage; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Proteins; Quinazolines; Thymidine

1988
Potentiation of quinazoline antifolate (CB3717) toxicity by dipyridamole in human lung carcinoma, A549, cells.
    Biochemical pharmacology, 1988, Jun-01, Volume: 37, Issue:11

    Topics: Carcinoma; Cell Survival; Dipyridamole; DNA; Drug Synergism; Folic Acid; Folic Acid Antagonists; Humans; Lung Neoplasms; Quinazolines; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1988
Quinazoline antifolates as inhibitors of growth, dihydrofolate reductase, and thymidylate synthetase of mouse neuroblastoma cells in culture.
    Molecular pharmacology, 1974, Volume: 10, Issue:2

    Topics: Animals; Cells, Cultured; Chromatography, Paper; Folic Acid Antagonists; Growth; Kinetics; Leucovorin; Methyltransferases; Mice; Neoplasms, Experimental; Neuroblastoma; Quinazolines; Thymidine; Thymidylate Synthase

1974
2,4-diamino-5, 6,7,8-tetrahydroquinazoline, a new pteridine antagonist.
    Biochemical and biophysical research communications, 1969, Feb-21, Volume: 34, Issue:4

    Topics: Animals; Depression, Chemical; Eukaryota; Folic Acid; Growth; Pteridines; Pterins; Quinazolines; Thymidine; Thymine

1969
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
    Advances in enzyme regulation, 1984, Volume: 22

    Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate

1984
Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717.
    Biochemical pharmacology, 1984, Oct-15, Volume: 33, Issue:20

    Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Deoxyuridine; Folic Acid; Leukemia L1210; Male; Methyltransferases; Mice; Mice, Inbred DBA; Quinazolines; Thymidine; Thymidylate Synthase

1984
The effect of halofuginone, Wellcome 993 C, oxytetracycline, and diminazene diaceturate on Babesia equi-infected lymphoblastoid cell cultures.
    The Journal of parasitology, 1984, Volume: 70, Issue:4

    Topics: Amidines; Animals; Antiprotozoal Agents; Babesia; Cell Line; Diminazene; DNA; Lymphocytes; Naphthoquinones; Oxytetracycline; Piperidines; Quinazolines; Quinazolinones; Thymidine

1984
Modulation of target enzyme associated with the action of antifolates.
    Advances in enzyme regulation, 1994, Volume: 34

    Topics: Antimetabolites, Antineoplastic; Carcinoma; Dose-Response Relationship, Drug; Drug Interactions; Evaluation Studies as Topic; Humans; Intestinal Neoplasms; Leucovorin; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1994
Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations.
    Cancer chemotherapy and pharmacology, 1994, Volume: 33, Issue:6

    Topics: Antineoplastic Agents; Carcinoma; Cell Division; Colonic Neoplasms; Humans; Indoles; Isoindoles; Methotrexate; Quinazolines; Thymidine; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured

1994
Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:3

    Topics: Animals; Antimalarials; Cell Division; Erythrocytes; Folic Acid Antagonists; HeLa Cells; Humans; In Vitro Techniques; Mice; Plasmodium falciparum; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1994
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
    Cancer research, 1993, Dec-01, Volume: 53, Issue:23

    Topics: Acyltransferases; Antineoplastic Agents; Cell Division; Cell Survival; Colonic Neoplasms; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Hypoxanthines; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1993
The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme.
    The Journal of biological chemistry, 1993, Jul-15, Volume: 268, Issue:20

    Topics: Cell Cycle; Cell Division; Cells, Cultured; Cycloheximide; Enzyme Stability; Humans; Protein Biosynthesis; Quinazolines; RNA, Messenger; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1993
Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.
    Journal of medicinal chemistry, 1996, Feb-16, Volume: 39, Issue:4

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Binding Sites; Carcinoma, Squamous Cell; Cell Cycle; Cell Line; DNA; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Growth Substances; Heterocyclic Compounds; Humans; Imidazoles; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mice; Mitosis; Molecular Structure; Phosphorylation; Platelet-Derived Growth Factor; Protein-Tyrosine Kinases; Quinazolines; Structure-Activity Relationship; Thymidine

1996
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Mar-04, Volume: 94, Issue:5

    Topics: Animals; Apoptosis; Colon; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Histocytochemistry; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Male; Mice; Mice, Inbred Strains; Quinazolines; RNA; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Suppressor Protein p53; Uridine

1997
Adenosine stimulation of DNA synthesis in human endothelial cells.
    The American journal of physiology, 1997, Volume: 272, Issue:3 Pt 2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Triphosphate; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Endothelium, Vascular; Humans; Kinetics; Poly A; Purinergic P1 Receptor Antagonists; Quinazolines; Tetradecanoylphorbol Acetate; Thioinosine; Thionucleotides; Thymidine; Triazoles; Umbilical Veins

1997
Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro.
    Cancer research, 1998, Jul-01, Volume: 58, Issue:13

    Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Culture Media, Conditioned; Dose-Response Relationship, Drug; Female; Humans; Quinazolines; Thiophenes; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Time Factors; Transfection; Tumor Cells, Cultured

1998
Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex.
    Experimental cell research, 1999, Feb-25, Volume: 247, Issue:1

    Topics: Carrier Proteins; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; DNA Fragmentation; DNA-Binding Proteins; DNA, Neoplasm; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Activation; Enzyme Inhibitors; Growth Inhibitors; Humans; Macromolecular Substances; Protein Serine-Threonine Kinases; Quinazolines; Retinoblastoma-Binding Protein 1; Thiophenes; Thymidine; Thymidylate Synthase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured

1999
Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:7

    Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thiophenes; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured

1999
Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.
    British journal of cancer, 1999, Volume: 80, Issue:11

    Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Cell Survival; Dipyridamole; Drug Synergism; Enzyme Inhibitors; Folic Acid; Leukemia L1210; Mice; Molecular Structure; Orosomucoid; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1999
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
    International journal of oncology, 1999, Volume: 15, Issue:6

    Topics: Cell Cycle; Cell Division; Culture Media; Drug Resistance; Enzyme Inhibitors; Fetal Blood; Head and Neck Neoplasms; Humans; Hypoxanthine; Inhibitory Concentration 50; Leucovorin; Leukemia; Methotrexate; Quinazolines; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured

1999
Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Deoxyuridine; Diarrhea; Digestive System; Dose-Response Relationship, Drug; Folic Acid; Intestinal Mucosa; Intestine, Large; Intestine, Small; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Weight Loss

2000
Modulation of RTX cytotoxicity by thymidine and dipyridamole in vitro: implications for chemotherapy.
    Cancer chemotherapy and pharmacology, 2000, Volume: 45, Issue:2

    Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Genes, p53; Humans; Phosphodiesterase Inhibitors; Quinazolines; Thiophenes; Thymidine; Tumor Cells, Cultured

2000
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:4

    Topics: Animals; Cell Division; Enzyme Inhibitors; Erythrocytes; Folic Acid Antagonists; Indoles; Isoindoles; Kinetics; Leukemia L1210; Mice; Plasmodium falciparum; Quinazolines; Thymidine; Thymidylate Synthase

2000
Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist.
    Biochemical pharmacology, 2000, Nov-15, Volume: 60, Issue:10

    Topics: Apoptosis Regulatory Proteins; Bacterial Proteins; Blood Platelets; Calcium; Carrier Proteins; Cells, Cultured; DNA; Humans; Intracellular Signaling Peptides and Proteins; Muscle, Smooth, Vascular; P-Selectin; Peptide Fragments; Platelet Aggregation; Pyrroles; Quinazolines; Receptor, PAR-1; Receptors, Thrombin; RNA-Binding Proteins; Thrombin; Thymidine; Transcription Factors; Triallate

2000
Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells.
    International immunology, 2001, Volume: 13, Issue:1

    Topics: Animals; CD8-Positive T-Lymphocytes; Clonal Deletion; Enterotoxins; Fas Ligand Protein; fas Receptor; Folic Acid Antagonists; Growth Inhibitors; Injections, Intraperitoneal; Injections, Intravenous; Ligands; Lymphocyte Activation; Lymphocyte Depletion; Membrane Glycoproteins; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Nucleic Acid Synthesis Inhibitors; Quinazolines; Staphylococcus aureus; Superantigens; T-Lymphocyte Subsets; Thiophenes; Thymidine; Thymidylate Synthase

2001
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
    Cancer research, 2001, May-01, Volume: 61, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase

2001
2-[11C]thymidine positron emission tomography as an indicator of thymidylate synthase inhibition in patients treated with AG337.
    Journal of the National Cancer Institute, 2003, May-07, Volume: 95, Issue:9

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Carbon Radioisotopes; Case-Control Studies; Enzyme Inhibitors; Female; Gastrointestinal Neoplasms; Humans; Liver; Male; Middle Aged; Quinazolines; Regression Analysis; Thymidine; Thymidylate Synthase; Tomography, Emission-Computed

2003
Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
    International journal of oncology, 2003, Volume: 23, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cecal Neoplasms; Cell Division; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Folic Acid; Glutamates; Hematinics; Humans; Hydroxymethyl and Formyl Transferases; Hypoxanthine; Ileal Neoplasms; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Pyrimidines; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured

2003
Insulin reduces the requirement for EGFR transactivation in bombesin-induced DNA synthesis.
    Biochemical and biophysical research communications, 2004, Jun-11, Volume: 318, Issue:4

    Topics: Animals; Bombesin; DNA; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Insulin; Mice; Protein Tyrosine Phosphatases; Quinazolines; Swiss 3T3 Cells; Thymidine; Transcriptional Activation; Tritium; Tyrphostins

2004
p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
    Cancer research, 2004, Jun-15, Volume: 64, Issue:12

    Topics: Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Stability; Fibrosarcoma; Folic Acid Antagonists; Humans; Methotrexate; Neoplastic Stem Cells; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Thymidine; Thymidylate Synthase; Trimetrexate; Tumor Suppressor Protein p14ARF; Tumor Suppressor Protein p53

2004
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
    Cancer research, 2005, Jun-01, Volume: 65, Issue:11

    Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Death; DNA Damage; DNA Topoisomerases, Type I; DNA, Neoplasm; DNA, Single-Stranded; Drug Screening Assays, Antitumor; Fluorodeoxyuridylate; Fluorouracil; Leukemia P388; Mice; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Topoisomerase I Inhibitors

2005
Gefitinib is effective against juvenile pilocytic astrocytoma in vitro.
    Pediatric blood & cancer, 2006, Volume: 47, Issue:3

    Topics: Astrocytoma; Cell Proliferation; Central Nervous System Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; ErbB Receptors; Flow Cytometry; Gefitinib; Gene Expression Profiling; Humans; Immunohistochemistry; Oligonucleotide Array Sequence Analysis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Thymidine; Tumor Cells, Cultured

2006
Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells.
    Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:10

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Carrier Proteins; Cell Cycle Proteins; Cell Line, Tumor; Dose-Response Relationship, Drug; ErbB Receptors; Eukaryotic Initiation Factor-4E; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Immunoblotting; Immunoprecipitation; Models, Biological; Phosphoproteins; Phosphorylation; Protein Kinases; Quinazolines; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Thymidine; TOR Serine-Threonine Kinases

2005
Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.
    Biochemical pharmacology, 2006, May-14, Volume: 71, Issue:10

    Topics: Animals; Area Under Curve; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Injections, Intravenous; Injections, Subcutaneous; Mice; Molecular Structure; Protein Tyrosine Phosphatases; Quinazolines; Rats; Thymidine; Tyrphostins; Xenograft Model Antitumor Assays

2006
Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors.
    European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:9

    Topics: Adenocarcinoma; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Cisplatin; Colonic Neoplasms; Enzyme Inhibitors; Fibrosarcoma; Fluorouracil; HT29 Cells; Humans; Quinazolines; Radionuclide Imaging; Radiopharmaceuticals; Thymidine; Thymidylate Synthase; Time Factors; Tritium

2006
An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed.
    Cancer chemotherapy and pharmacology, 2007, Volume: 59, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Cell Line, Tumor; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; HT29 Cells; Humans; Immunoglobulin Fab Fragments; Injections, Intravenous; Mice; Mice, Nude; Quinazolines; Reproducibility of Results; Thiophenes; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Xenograft Model Antitumor Assays

2007
Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
    Cancer chemotherapy and pharmacology, 2007, Volume: 59, Issue:6

    Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Fluorouracil; Humans; NF-kappa B; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2007
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
    Blood, 2007, Sep-15, Volume: 110, Issue:6

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Aurora Kinase A; Aurora Kinase B; Aurora Kinases; Case-Control Studies; Cell Cycle; Cell Proliferation; Colony-Forming Units Assay; Daunorubicin; Drug Synergism; Drug Therapy, Combination; Drug Tolerance; Enzyme Inhibitors; Female; Flow Cytometry; Humans; Immunoblotting; Leukemia; Mice; Mice, Inbred BALB C; Organophosphates; Protein Serine-Threonine Kinases; Quinazolines; Thymidine; Transplantation, Heterologous; Tubulin Modulators; Vincristine

2007
[18F]Fluorothymidine positron emission tomography before and 7 days after gefitinib treatment predicts response in patients with advanced adenocarcinoma of the lung.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Nov-15, Volume: 14, Issue:22

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Fluorine Radioisotopes; Gefitinib; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Positron-Emission Tomography; Prognosis; Quinazolines; Radiopharmaceuticals; ROC Curve; Thymidine; Time; Tomography, X-Ray Computed

2008
Endosomal signalling of epidermal growth factor receptors contributes to EGF-stimulated cell cycle progression in primary hepatocytes.
    European journal of pharmacology, 2011, Mar-05, Volume: 654, Issue:2

    Topics: Animals; Cell Cycle; Cell Division; Endosomes; Epidermal Growth Factor; ErbB Receptors; Hepatocytes; Male; Microscopy, Confocal; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Thymidine; Tyrphostins

2011
Metabolic imaging allows early prediction of response to vandetanib.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:2

    Topics: Aged; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclins; Dihydroxyphenylalanine; Down-Regulation; Female; Fluorodeoxyglucose F18; G1 Phase; Glucose; Humans; Male; Mice; Mice, SCID; Microarray Analysis; Piperidines; Positron-Emission Tomography; Proto-Oncogene Proteins c-ret; Quality Control; Quinazolines; Radiopharmaceuticals; Resting Phase, Cell Cycle; RNA, Neoplasm; Signal Transduction; Thymidine; Thyroid Neoplasms; Tomography, Emission-Computed

2011
Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Mar-01, Volume: 17, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Dideoxynucleosides; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Fluorouracil; HCT116 Cells; Humans; Immunoblotting; Ki-67 Antigen; Methotrexate; Mice; Mice, Nude; Organophosphates; Positron-Emission Tomography; Quinazolines; Radiopharmaceuticals; Thymidine; Thymidine Kinase; Xenograft Model Antitumor Assays

2011
Thiothymidine combined with UVA as a potential novel therapy for bladder cancer.
    British journal of cancer, 2011, Jun-07, Volume: 104, Issue:12

    Topics: Animals; Apoptosis; Cell Line, Tumor; DNA Damage; Female; Humans; Quinazolines; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Thiophenes; Thymidine; Ultraviolet Therapy; Urinary Bladder Neoplasms

2011
A pilot study for the early assessment of the effects of BMS-754807 plus gefitinib in an H292 tumor model by [(18)F]fluorothymidine-positron emission tomography.
    Investigational new drugs, 2013, Volume: 31, Issue:3

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Fluorine Radioisotopes; Gefitinib; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Pilot Projects; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrazoles; Quinazolines; Receptor, IGF Type 1; Thymidine; Triazines; Tumor Burden

2013
Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Feb-05, Volume: 110, Issue:6

    Topics: Anti-HIV Agents; Base Sequence; CD4-Positive T-Lymphocytes; Deoxyuracil Nucleotides; DNA Glycosylases; DNA, Viral; Enzyme Inhibitors; Gene Knockdown Techniques; HIV-1; Host-Pathogen Interactions; HT29 Cells; Humans; Immunity, Innate; Macrophages; Models, Biological; Mutation; Quinazolines; Reverse Transcription; Thiophenes; Thymidine; Thymidylate Synthase; Virion; Virus Integration

2013
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
    Journal of medicinal chemistry, 2013, May-23, Volume: 56, Issue:10

    Topics: Aminopeptidases; Animals; Cell Proliferation; Chelating Agents; Chromatography, Thin Layer; Cobalt; Crystallography, X-Ray; Down-Regulation; Enzyme Activation; HeLa Cells; Human Umbilical Vein Endothelial Cells; Humans; Indicators and Reagents; Manganese; Metals; Methionine; Mice; Models, Molecular; Protease Inhibitors; Pyridines; Quinazolines; RNA, Small Interfering; Thymidine; Transfection; Zinc

2013