Page last updated: 2024-08-17

thymidine and levoleucovorin

thymidine has been researched along with levoleucovorin in 98 studies

Research

Studies (98)

TimeframeStudies, this research(%)All Research%
pre-199078 (79.59)18.7374
1990's10 (10.20)18.2507
2000's6 (6.12)29.6817
2010's4 (4.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Roberts, D; Warmath, EV1
Heidelberger, C; Moran, RG; Mulkins, M1
Harrap, KR; Straw, JA; Talbot, DC; Taylor, GA1
Lietman, PS; Rogers, HJ2
Bertino, JR1
Browman, GP; Harrap, KR; Taylor, GA1
Shearer, M; Taylor-Papadimitriou, J; Watling, D1
Grindey, GB; Pavelic, ZP; Semon, JH1
Ganeshaguru, K; Hoffbrand, AV1
Frei, E; Howell, SB; Krishan, A1
Hannan, GN; McAuslan, BR; Reilly, W1
Neugut, AI; Weinstein, IB1
Sauer, H; Schalhorn, A; Wilmanns, W2
Friedman, MA; Sadée, W1
Frei, E1
Brown, B; Frei, E; Tattersall, MH1
Frei, E; Jaffe, N; Parker, L; Pitman, S; Tattersall, MH1
Hsie, AW; Schröder, CH1
Harrap, KR; Jackson, RC; Taylor, GA1
Brown, BL; Frei, E; Tattersall, MH1
White, PJ; Widdowson, D1
Greenberg, ML; Waxman, S1
Saunders, J; Wickramasinghe, SN; Williams, G1
Bull, JM; Chabner, BA; Pinedo, HM; Zaharko, DS1
Azizkhan, JC; Speeg, KV; Stromberg, K1
Cloos, J; Noordhuis, P; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL1
Grem, JL1
Rustum, YM; Yin, MB1
Chang, CC; Li, IC; Trosko, JE1
Booker, L; Browman, GP; Spiegl, P1
Kane, MA; Raptis, G; Roth, E; Schreiber, C; Waxman, S1
Arbuck, SG; Creaven, PJ; Herrera, L; Mittelman, A; Petrelli, N; Rustum, YM; Trave, F; Zakrzewski, SF1
Akiyama, Y; Kiriyama, Y; Kito, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A2
Bertino, JR; Sobrero, AF1
Barlowe, CK; Goldman, ID; Matherly, LH; Phillips, VM1
Bertino, JR; Mini, E; Moroson, BA1
Lönn, S; Lönn, U1
Branda, RF; McCormack, JJ; Perlmutter, CA1
Burres, NS; Cass, CE1
Diddens, H; Niethammer, D; Teufel, T1
Bygbjerg, IC1
Rustum, YM1
Grunberg, E1
Canellos, GP; Greenberg, NH; Mead, JA; Schrecker, AW1
Grossowicz, N; Mandelbaum-Shavit, F1
Makulu, DR1
Myers, RF; Thirugnanam, M1
Berry, CL; Germain, J1
Cooper, LE; Groth, DP; Vogler, WR1
Carlin, SC; Friedkin, M; Rosenberg, RN; VandeVenter, L1
Bishop, A; Foerster, J; Hryniuk, WM1
McBurney, MW; Whitmore, GF1
Borsa, J; Whitmore, GF2
Bertino, JR; McCullough, JL; O'Brien, P1
Hakala, MT1
Loehr, EV; Roberts, D1
Singer, R; Weidauer, H1
Beaulieu, D; Matiaszuk, NV; Pottier, A; Rosenblatt, DS; Vuchich, MJ; Whitehead, VM1
Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ1
Kano, Y; Kubota, T; Miura, Y; Sakamoto, S; Sakuraya, K; Taguchi, H; Takaku, F1
Abelson, HT; Beardsley, GP; Fosburg, MT; Goorin, AM; Gorka, C; Link, D; Link, M1
Samuels, LL; Straw, JA1
Chu, EH; Li, IC1
Leyva, A; Nederbragt, H; Pinedo, HM; Uitendaal, MP; van der Grint, L1
Bogyo, D; Mihich, E1
Browman, GP; Calvert, AH; Harrap, KR; Hart, LI; Taylor, GA1
Evans, RM; Hakala, MT; Laskin, JD1
Ariel, M; Grossowicz, N; Holtzer, E; Lavi, H1
Chanarin, I; Deacon, R; Lumb, M; Perry, J1
Bruno, S; Creaven, P; Grindey, G; Kinahan, J; Ledesma, E; Mittelman, A; Moayeri, H; Priore, R; Zakrzewski, S1
Browman, GP1
Sauer, H; Schalhorn, A1
Hida, K; Kano, Y; Sakamoto, S; Suda, K; Takaku, F1
Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ1
Handschumacher, RE; Pizzorno, G; Sun, Z1
Cao, S; Rustum, YM; Yin, MB1
D'Incalci, M; Erba, E; Sen, S; Sessa, C; Vikhanskaya, FL1
Adamson, PC; Balis, FM; Montello, MJ; Murphy, RF; O'Brien, M; Sorensen, JM; Widemann, BC1
Canestrari, JG; McGuire, JJ; Nagel, GS1
Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D1
Chango, A; James, SJ; Melnyk, S; Pogribna, M; Pogribny, I; Yi, P1
Beijnen, JH; Boogerd, W; Mathĵt, RA; Schellens, JH; Schornagel, JH; Soesan, M; van den Bongard, HJ1
Aggarwal, BB; Majumdar, S1
GROSSOWICZ, N; MANDELBAUM, F1
MATSUYA, Y; YAMANE, I1
SHIRAHA, Y1
DUNN, MS; VIJAYARAGHAVAN, PK1
SAUBERLICH, HE1
Beijnen, JH; Schellens, JH1
Nelson, LS; Smith, SW1
Adamson, PC; Balis, FM; Boron, M; Cole, DE; Eby, M; Fox, E; Ivy, P; Jayaprakash, N; Kim, A; Murphy, RF; O'Brien, M; Shalabi, A; Widemann, BC1
Bhinder, B; Djaballah, H; Fischer, MA; Früh, K; Hirsch, AJ; Nelson, JA; Parkins, C; Radu, C; Shum, D; Smith, JL; Stein, DA1
Daignan-Fornier, B; Hürlimann, HC; Pinson, B; Saint-Marc, C1
Aboagye, EO; Doblas, S; Döring, C; Faber, C; Fricke, IB; Griffiths, JR; Heinzmann, K; Heller, A; Hermann, S; Honess, DJ; Jacobs, AH; Just, N; Rieder, N; Schäfers, KP; Schelhaas, S; Schneider, R; Sinkus, R; Smith, DM; Wachsmuth, L1

Reviews

5 review(s) available for thymidine and levoleucovorin

ArticleYear
The fluoropyrimidines: biochemical mechanisms and design of clinical trials.
    Cancer chemotherapy and pharmacology, 1978, Volume: 1, Issue:2

    Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Metabolism; Methotrexate; Pyrimidines; Thymidine; Thymine

1978
Methotrexate revisited.
    Medical and pediatric oncology, 1976, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Alkalies; Aminopterin; Animals; Bone Marrow; Bone Neoplasms; Drug Therapy, Combination; Female; Folic Acid Antagonists; Humans; Kidney; Kidney Failure, Chronic; Leucovorin; Leukemia L1210; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Thymidine; Vincristine

1976
Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience.
    Seminars in oncology, 1992, Volume: 19, Issue:2 Suppl 3

    Topics: Colonic Neoplasms; Deoxyuridine; Dipyridamole; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Nucleosides; Nucleotides; RNA, Neoplasm; Thymidine; Tumor Cells, Cultured; Uridine Monophosphate

1992
The effect of trimethoprim on the activity of sulfonamides and antibiotics in experimental infections.
    The Journal of infectious diseases, 1973, Volume: 128

    Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bacterial Infections; Drug Synergism; Escherichia coli Infections; Haemophilus Infections; Klebsiella Infections; Leucovorin; Mice; Microbial Sensitivity Tests; Pneumococcal Infections; Proteus Infections; Pseudomonas aeruginosa; Pseudomonas Infections; Salmonella Infections; Staphylococcal Infections; Sulfonamides; Thymidine; Trimethoprim

1973
[Results of primary antineoplastic chemotherapy in advanced keratinizing squamous epithelial carcinomas of the head and neck region].
    Laryngologie, Rhinologie, Otologie, 1981, Volume: 60, Issue:4

    Topics: Adult; Aged; Bleomycin; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Inosine; Leucovorin; Male; Methotrexate; Middle Aged; Prognosis; Thymidine; Vincristine

1981

Other Studies

93 other study(ies) available for thymidine and levoleucovorin

ArticleYear
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
    European journal of cancer, 1975, Volume: 11, Issue:11

    Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antagonists; Humans; Hypoxanthines; Leucovorin; Leukemia, Lymphoid; Methotrexate; Purines; Thymidine

1975
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity.
    Proceedings of the National Academy of Sciences of the United States of America, 1979, Volume: 76, Issue:11

    Topics: Animals; Cell Division; Cells, Cultured; Floxuridine; Humans; Hypoxanthines; Leucovorin; Leukemia, Experimental; Methotrexate; Methyltransferases; Mice; Thymidine; Thymidylate Synthase

1979
Some observations on the reversibility of methotrexate toxicity in normal proliferating tissues.
    Journal of the National Cancer Institute, 1977, Volume: 58, Issue:1

    Topics: Animals; Bone Marrow; Bone Marrow Cells; DNA; Drug Interactions; Drug Therapy, Combination; Hypoxanthines; Intestinal Mucosa; Intestines; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Purines; Pyrimidines; Thymidine

1977
Effect of folate and folinate on 3H-thymidine incorporation by transforming human lymphocytes in vitro.
    Experientia, 1977, May-15, Volume: 33, Issue:5

    Topics: Concanavalin A; DNA; DNA Replication; Dose-Response Relationship, Drug; Folic Acid; Humans; Leucovorin; Lymphocyte Activation; Lymphocytes; Thymidine; Tritium

1977
"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.
    Seminars in oncology, 1977, Volume: 4, Issue:2

    Topics: Animals; Asparaginase; Breast Neoplasms; Carboxypeptidases; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia; Lung Neoplasms; Lymphoma; Melanoma; Methotrexate; Neoplasms; Osteosarcoma; Tetrahydrofolates; Thymidine

1977
Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines.
    Chemico-biological interactions, 1977, Volume: 18, Issue:1

    Topics: Allopurinol; Animals; Drug Synergism; Female; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Purines; Pyrimidines; Thymidine; Time Factors

1977
The in vitro effect of trimethoprim on blastogenic transformation of human peripheral blood lymphocytes.
    Biochemical pharmacology, 1977, Sep-01, Volume: 26, Issue:17

    Topics: Autoradiography; Cells, Cultured; Concanavalin A; Deoxyuridine; Folic Acid; Formates; Humans; In Vitro Techniques; Leucine; Leucovorin; Lymphocyte Activation; Lymphocytes; Thymidine; Time Factors; Trimethoprim; Uridine

1977
Growth requirements of calf lens epithelium in culture.
    Journal of cellular physiology, 1978, Volume: 95, Issue:1

    Topics: Animals; Blood; Cattle; Cell Division; Cell Line; Culture Media; Epithelial Cells; Fibroblasts; Folic Acid; Lens, Crystalline; Leucovorin; Methotrexate; Mice; Mitomycins; Thymidine

1978
Modulation versus rescue of antimetabolite toxicity by salvage metabolites administered by continuous infusion.
    Antibiotics and chemotherapy, 1978, Volume: 23

    Topics: Animals; Drug Therapy, Combination; Duodenal Diseases; Female; Infusions, Parenteral; Inosine; Lethal Dose 50; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Thymidine

1978
The effect of deoxyuridine, vitamin B12, folate and alcohol on the uptake of thymidine and on the deoxynucleoside triphosphate concentrations in normal and megaloblastic cells.
    British journal of haematology, 1978, Volume: 40, Issue:1

    Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyadenine Nucleotides; Deoxyuridine; DNA; Ethanol; Folic Acid; Humans; Leucovorin; Lymphocytes; Tetrahydrofolates; Thymidine; Thymine Nucleotides; Vitamin B 12

1978
Cytokinetic comparison of thymidine and leucovorin rescue of marrow in humans after exposure to high-dose methotrexate.
    Cancer research, 1979, Volume: 39, Issue:4

    Topics: Bone Marrow; Cell Cycle; DNA, Neoplasm; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Thymidine

1979
Stimulation of endothelia cell proliferation by precursors of thymidylate.
    Journal of cellular physiology, 1979, Volume: 100, Issue:1

    Topics: Animals; Aorta; Cattle; Cell Count; Cell Division; Cells, Cultured; Clone Cells; Cornea; Culture Media; Endothelium; Folic Acid; gamma-Glutamyl Hydrolase; Leucovorin; Serum Albumin, Bovine; Thymidine

1979
Growth limitation of BHK-21 cells and its relation to folate metabolism.
    In vitro, 1979, Volume: 15, Issue:5

    Topics: Aminopterin; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Drug Resistance; Folic Acid; Hypoxanthines; Kidney; Leucovorin; Tetrahydrofolate Dehydrogenase; Thymidine

1979
The biochemistry of the citrovorum factor rescue effect in normal bone marrow cells after high-dose methotrexate.
    European journal of cancer, 1979, Volume: 15, Issue:10

    Topics: Adult; Bone Marrow; Cells, Cultured; Deoxyuridine; Humans; Leucovorin; Lymphocytes; Male; Methotrexate; Middle Aged; Osteosarcoma; Thymidine; Thymidine Kinase

1979
The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects.
    Nature, 1975, Jan-17, Volume: 253, Issue:5488

    Topics: Allopurinol; Animals; Drug Therapy, Combination; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Thymidine

1975
New approaches to cancer chemotherapy with methotrexate.
    The New England journal of medicine, 1975, Apr-17, Volume: 292, Issue:16

    Topics: Adult; Animals; Biological Transport; Bone Marrow; Creatinine; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Kidney; Leucovorin; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Purines; Thymidine; Thymine Nucleotides

1975
A temperature-sensitive auxotropic variant of Chinese hamster ovary cells.
    Experimental cell research, 1975, Mar-01, Volume: 91, Issue:1

    Topics: Animals; Bromodeoxyuridine; Cell Line; Clone Cells; Cricetinae; Female; Glycine; Hypoxanthines; Leucovorin; Molecular Biology; Ovary; Temperature; Tetrahydrofolate Dehydrogenase; Thymidine; Uridine

1975
Aspects of the biochemical pharmacology of cytembena.
    Neoplasma, 1975, Volume: 22, Issue:3

    Topics: Acrylates; Animals; Cell Division; DNA Nucleotidyltransferases; DNA, Neoplasm; Dose-Response Relationship, Drug; Folic Acid; Formate-Tetrahydrofolate Ligase; Glycine Hydroxymethyltransferase; Humans; In Vitro Techniques; Leucine; Leucovorin; Leukemia L1210; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Rats; Sarcoma, Yoshida; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidine; Thymidine Kinase; Thymidylate Synthase; Uridine

1975
Methotrexate-thymidine treatment of murine leukemia.
    Annals of the New York Academy of Sciences, 1975, Aug-08, Volume: 255

    Topics: Allopurinol; Animals; Drug Evaluation, Preclinical; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidine

1975
The nutritional requirements of methicillin-dependent and -resistant strains of Pediococcus cerevisiae.
    Journal of general microbiology, 1976, Volume: 92, Issue:1

    Topics: Acetates; Alanine; Amino Acids; Culture Media; Glucose; Lactates; Leucovorin; Methicillin; Mutation; Pantothenic Acid; Pediococcus; Penicillin Resistance; Penicillins; Species Specificity; Thioglycolates; Thymidine

1976
Sequential use of methotrexate, folinic acid, and cytosine arabinoside in the treatment of acute leukemia.
    European journal of cancer, 1976, Volume: 12, Issue:8

    Topics: Adult; Bone Marrow; Bone Marrow Cells; Child; Cytarabine; Deoxyuridine; DNA; Drug Administration Schedule; Female; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mitosis; Thymidine; Thymine

1976
Effects of anticonvulsant drugs on the synthesis of DNA and protein by human bone marrow cells in vitro.
    Scandinavian journal of haematology, 1976, Volume: 17, Issue:4

    Topics: Bone Marrow; Bone Marrow Cells; DNA; Folic Acid; Humans; Leucine; Leucovorin; Phenobarbital; Phenytoin; Protein Biosynthesis; Thymidine

1976
The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides.
    Cancer research, 1976, Volume: 36, Issue:12

    Topics: Adenosine; Animals; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Granulocytes; Guanosine; Hematopoietic Stem Cells; Inosine; Leucovorin; Leukocytes; Male; Methotrexate; Mice; Mice, Inbred C57BL; Ribonucleosides; Thymidine

1976
The stimulation by methotrexate of human chorionic gonadotropin and placental alkaline phosphatase in cultured choriocarcinoma cells.
    Cancer research, 1976, Volume: 36, Issue:12

    Topics: Alkaline Phosphatase; Cells, Cultured; Choriocarcinoma; Chorionic Gonadotropin; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; L-Lactate Dehydrogenase; Leucovorin; Methotrexate; Neoplasm Proteins; Placenta; Pregnancy; RNA, Neoplasm; Thymidine; Uterine Neoplasms

1976
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
    Seminars in oncology, 1992, Volume: 19, Issue:2 Suppl 3

    Topics: Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovorin; Mice; Mice, Inbred BALB C; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Monophosphate

1992
Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition.
    Cancer communications, 1991, Volume: 3, Issue:2

    Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Leucovorin; Thymidine; Time Factors

1991
Thymidylate synthetase gene as a quantitative mutation marker in Chinese hamster cells.
    Mutation research, 1990, Volume: 243, Issue:3

    Topics: Animals; Cells, Cultured; Culture Media; Ethyl Methanesulfonate; Gene Expression; Genetic Markers; Hypoxanthine; Hypoxanthines; Leucovorin; Mutation; Thymidine; Thymidylate Synthase; Time Factors; Ultraviolet Rays

1990
Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:2

    Topics: Cell Division; Cell Line; Drug Antagonism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Lymphoid Tissue; Methotrexate; Polyglutamic Acid; Tetrahydrofolates; Thymidine; Uridine

1985
Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
    Cancer research, 1987, Dec-15, Volume: 47, Issue:24 Pt 1

    Topics: Adenosine; Carcinoma, Squamous Cell; Cell Survival; Fluorouracil; Folic Acid; Glucose; Humans; KB Cells; Leucovorin; Leukemia, Myeloid, Acute; Methotrexate; Nasopharyngeal Neoplasms; Pentosephosphates; Phosphoribosyl Pyrophosphate; Thymidine

1987
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:5

    Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia L1210; Mice; RNA; Stomach Neoplasms; Thymidine; Thymidylate Synthase

1987
Synergistic effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
    Leukemia research, 1989, Volume: 13, Issue:2

    Topics: Aphidicolin; Cell Line; Cytarabine; Diterpenes; DNA Damage; Drug Combinations; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Phosphorylation; Thymidine

1989
Sequential combination of methotrexate and 1-beta-D-arabinofuranosylcytosine shows synergistic effect on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: Arabinofuranosylcytosine Triphosphate; Cycloheximide; Cytarabine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Thymidine; Tumor Cells, Cultured

1989
Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
    International journal of cell cloning, 1986, Volume: 4, Issue:1

    Topics: Adenocarcinoma; Animals; Cattle; Cell Adhesion; Colonic Neoplasms; Colony-Forming Units Assay; Culture Media; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Methotrexate; Neoplastic Stem Cells; Quinazolines; Thymidine; Trimetrexate

1986
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
    The Journal of biological chemistry, 1987, Jan-15, Volume: 262, Issue:2

    Topics: Adenosine; Animals; Cell Division; Floxuridine; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mice; Thymidine

1987
Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin.
    Cancer treatment reports, 1987, Volume: 71, Issue:4

    Topics: Cell Division; Cell Line; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Leukemia, Lymphoid; T-Lymphocytes; Thymidine

1987
Increased levels of DNA lesions induced by leucovorin-5-fluoropyrimidine in human colon adenocarcinoma.
    Cancer research, 1988, Aug-01, Volume: 48, Issue:15

    Topics: Adenocarcinoma; Aphidicolin; Cell Line; Cell Survival; Colonic Neoplasms; Diterpenes; DNA; DNA Damage; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Pyrimidines; Thymidine

1988
Cellular pharmacology of chloroquinoxaline sulfonamide and a related compound in murine B16 melanoma cells.
    Biochemical pharmacology, 1988, Dec-01, Volume: 37, Issue:23

    Topics: Animals; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Deoxyuridine; DNA; Flow Cytometry; Leucovorin; Melanoma; Mice; Quinoxalines; Sulfanilamides; Sulfaquinoxaline; Tetrahydrofolate Dehydrogenase; Thymidine

1988
Inhibition of methotrexate-induced differentiation of cultured human choriocarcinoma (BeWo) cells by thymidine.
    Cancer research, 1987, Oct-01, Volume: 47, Issue:19

    Topics: Cell Differentiation; Cells, Cultured; Choriocarcinoma; DNA; DNA Replication; Female; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Methotrexate; Pregnancy; Thymidine; Uterine Neoplasms

1987
High-dose methotrexate therapy with leucovorin rescue: in vitro investigations on human osteosarcoma cell lines.
    Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:2

    Topics: Cell Line; Cell Survival; Deoxyuridine; DNA, Neoplasm; Humans; Leucovorin; Methotrexate; Osteosarcoma; Thymidine; Tumor Cells, Cultured

1987
Effect of proguanil and cycloguanil on human lymphocytes in vitro.
    European journal of clinical pharmacology, 1985, Volume: 28, Issue:3

    Topics: Humans; Leucovorin; Lymphocyte Activation; Proguanil; Thymidine; Triazines

1985
Selective modulation of 5-fluorouracil action in patients with colorectal carcinoma.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1985, Volume: 4, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Kinetics; Leucovorin; Mice; Mice, Inbred BALB C; Rats; Rectal Neoplasms; Thymidine

1985
The effect of treatment with cytotoxic agents on mouse spleen dihydrofolate reductase activity.
    Cancer research, 1967, Volume: 27, Issue:4

    Topics: Animals; Cyclophosphamide; Floxuridine; Folic Acid; In Vitro Techniques; Leucovorin; Male; Methotrexate; Mice; Nucleosides; Organ Size; Spleen; Tetrahydrofolate Dehydrogenase; Thymidine

1967
Effect of folinate on thymidine uptake by Pediococcus cerevisiae.
    Journal of bacteriology, 1968, Volume: 95, Issue:4

    Topics: Aminopterin; Carbon Isotopes; Deoxyuridine; Floxuridine; Glucose; Hydrogen-Ion Concentration; Iodoacetates; Leucovorin; Methotrexate; Pediococcus; Temperature; Thymidine; Thymine; Tritium; Uracil

1968
Mode of action of methotrexate upon insulin-antibody formation in guinea pigs.
    Biochemical pharmacology, 1972, Feb-15, Volume: 21, Issue:4

    Topics: Adenosine; Animals; Antibody Formation; Deoxyadenosines; Depression, Chemical; Drug Antagonism; Floxuridine; Formates; Guanosine; Guinea Pigs; Immunization; Immunosuppressive Agents; Insulin Antibodies; Iodine Isotopes; Leucovorin; Male; Mathematics; Methotrexate; Swine; Tetrahydrofolates; Thymidine; Time Factors

1972
Nutrient media for plant-parasitic nematodes. VI. Nucleic acids content and nucleotide synthesis in Aphelenchoides rutgersi.
    Experimental parasitology, 1974, Volume: 36, Issue:2

    Topics: Adenosine Monophosphate; Animals; Carbon Radioisotopes; Culture Media; Cytidine Monophosphate; DNA; Folic Acid Antagonists; Glucose; Glycine; Guanosine Monophosphate; Inosine; Leucovorin; Lipids; Methods; Nematoda; Nucleotides; Orotic Acid; Protein Biosynthesis; RNA; Thymidine; Tritium; Uridine Monophosphate

1974
Absence of the third molar tooth in the mouse: its relevance to human malformation.
    The Journal of pathology, 1972, Volume: 108, Issue:1

    Topics: Animals; Anodontia; Deficiency Diseases; DNA; Female; Humans; Injections, Intraperitoneal; Leucovorin; Liver; Methotrexate; Mice; Mice, Inbred CBA; Molar; Thymidine; Tooth Abnormalities; Tritium

1972
Correlation of cytosine arabinoside-induced increment in growth fraction of leukemic blast cells with clinical response.
    Cancer, 1974, Volume: 33, Issue:3

    Topics: Adult; Aged; Bone Marrow; Bone Marrow Cells; Cell Division; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Female; Humans; Leucovorin; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mitosis; Thymidine; Time Factors; Tritium

1974
Quinazoline antifolates as inhibitors of growth, dihydrofolate reductase, and thymidylate synthetase of mouse neuroblastoma cells in culture.
    Molecular pharmacology, 1974, Volume: 10, Issue:2

    Topics: Animals; Cells, Cultured; Chromatography, Paper; Folic Acid Antagonists; Growth; Kinetics; Leucovorin; Methyltransferases; Mice; Neoplasms, Experimental; Neuroblastoma; Quinazolines; Thymidine; Thymidylate Synthase

1974
Clinical correlates of in vitro effect of methotrexate on acute leukemia blasts.
    Cancer research, 1974, Volume: 34, Issue:10

    Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Cell Biology; Cell Survival; Child; DNA, Neoplasm; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Purines; Remission, Spontaneous; Thymidine; Tritium

1974
Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells.
    Cell, 1974, Volume: 2, Issue:3

    Topics: Adenosine; Animals; Cell Fusion; Cell Survival; Cells, Cultured; Chromatography, DEAE-Cellulose; Clone Cells; Cricetinae; Crosses, Genetic; Culture Media; DNA; Female; Folic Acid; Glycine; Hybrid Cells; Leucovorin; Methotrexate; Mutation; Ovary; Phenotype; RNA; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium

1974
Studies relating to the mode of action of methotrexate. 3. Inhibition of thymidylate synthetase in tissue culture cells and in cell-free systems.
    Molecular pharmacology, 1969, Volume: 5, Issue:4

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Culture Techniques; Deoxyuridine; DNA; Embryo, Mammalian; Escherichia coli; Folic Acid; Histocytochemistry; Kinetics; L Cells; Leucovorin; Methotrexate; Mice; Nucleotides; RNA; Thymidine; Transferases; Tritium

1969
Studies relating to the mode of action of methotrexate. II. Studies on sites of action in L-cells in vitro.
    Molecular pharmacology, 1969, Volume: 5, Issue:4

    Topics: Animals; Cattle; Culture Media; Culture Techniques; L Cells; Leucovorin; Methotrexate; Nucleosides; Nucleotides; Purines; Tetrahydrofolate Dehydrogenase; Thymidine

1969
Inhibition of growth of leukemia cells by enzymic folate depletion.
    Science (New York, N.Y.), 1971, Apr-09, Volume: 172, Issue:3979

    Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; Folic Acid; Humans; Hypoxanthines; In Vitro Techniques; Leucovorin; Leukemia L1210; Leukemia, Experimental; Methotrexate; Pseudomonas; Serine; Thymidine

1971
Homofolate and tetrahydrohomofolate, inhibitors of purine synthesis.
    Cancer research, 1971, Volume: 31, Issue:6

    Topics: Animals; Culture Media; Culture Techniques; Folic Acid; Glycine; Leucovorin; Methotrexate; Neoplasms, Experimental; Purines; Sarcoma, Experimental; Thymidine

1971
Elevation of thymidylate synthetase activity in CCRF-CEM cells.
    Cancer research, 1971, Volume: 31, Issue:9

    Topics: Cell Line; Cells, Cultured; Child; Deoxyuridine; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Methotrexate; Methyltransferases; Thymidine; Uracil Nucleotides

1971
Differential effects of folinic acid and glycine, adenosine, and thymidine as rescue agents in methotrexate-treated human cells in relation to the accumulation of methotrexate polyglutamates.
    Molecular pharmacology, 1982, Volume: 21, Issue:3

    Topics: Adenosine; Deoxyuridine; DNA; Fibroblasts; Glycine; Humans; Leucovorin; Methotrexate; Polyglutamic Acid; Thymidine; Time Factors

1982
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
    Advances in enzyme regulation, 1984, Volume: 22

    Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate

1984
Effects of leucovorin and methylcobalamin with N2O anesthesia.
    The Journal of laboratory and clinical medicine, 1984, Volume: 104, Issue:5

    Topics: Bone Marrow; Deoxyuridine; DNA; Folic Acid; Humans; Leucovorin; Nitrous Oxide; Thymidine; Time Factors; Vitamin B 12

1984
Methotrexate-induced renal impairment: clinical studies and rescue from systemic toxicity with high-dose leucovorin and thymidine.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:3

    Topics: Adolescent; Adult; Child; Creatinine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Inulin; Kidney Diseases; Kinetics; Leucovorin; Methotrexate; Neoplasms; Thymidine

1983
Improved therapeutic index with high-dose methotrexate: comparison of thymidine-purine rescue with citrovorum factor rescue in mice.
    Cancer research, 1984, Volume: 44, Issue:6

    Topics: Animals; Brain Neoplasms; Deoxycytidine; DNA Replication; Dose-Response Relationship, Drug; Hypoxanthine; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidine; Thymine

1984
Mutants of Chinese hamster cells deficient in thymidylate synthetase.
    Journal of cellular physiology, 1984, Volume: 120, Issue:2

    Topics: Aminopterin; Animals; Cell Line; Cricetinae; Cricetulus; Culture Media; Drug Resistance; Leucovorin; Lung; Methyltransferases; Mutation; Thymidine; Thymidylate Synthase

1984
Biochemical control of high-dose methotrexate/Leucovorin rescue therapy.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 74

    Topics: Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Humans; Leucovorin; Methotrexate; Neoplasms; Thymidine; Thymidine Kinase

1980
Reversal of methotrexate inhibition of colony growth of L1210 leukemia cells in semisolid medium.
    Cancer research, 1981, Volume: 41, Issue:3

    Topics: Animals; Bone Marrow; Cell Division; Clone Cells; Culture Media; Inosine; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Thymidine

1981
Reversal of the in vitro methotrexate suppression of cell-mediated immune response by folinic acid and thymidine plus hypoxanthine.
    Cancer research, 1980, Volume: 40, Issue:3

    Topics: Animals; Cells, Cultured; Drug Interactions; Hypoxanthines; Immune Tolerance; Immunity, Cellular; Leucovorin; Methotrexate; Mice; Thymidine; Time Factors

1980
The intracellular mechanism of action of metoprine (DDMP).
    European journal of cancer, 1980, Volume: 16, Issue:12

    Topics: Animals; Cell Survival; Cells, Cultured; Deoxyuridine; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimethamine; Pyrimidines; Thymidine

1980
Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.
    Cancer research, 1981, Volume: 41, Issue:9 Pt 1

    Topics: Animals; Carcinoma; Cell Line; Deoxyribonucleosides; Deoxyribose; Deoxyuridine; Drug Synergism; Fluorouracil; Humans; Inosine; Leucovorin; Mice; Sarcoma, Experimental; Thymidine; Thymidylate Synthase

1981
Physiological and enzymatic properties of a thymidine-requiring Pediococcus cerevisiae mutant.
    Journal of bacteriology, 1982, Volume: 150, Issue:2

    Topics: Aminopterin; Folic Acid; Leucovorin; Methotrexate; Methyltransferases; Mutation; Pediococcus; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidylate Synthase

1982
A comparison of tetrahydrofolate and 5-formyltetrahydrofolate in correcting the impairment of thymidine synthesis in pernicious anaemia.
    Scandinavian journal of haematology, 1982, Volume: 28, Issue:4

    Topics: Anemia, Pernicious; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Leucovorin; Tetrahydrofolates; Thymidine

1982
Phase I study of high-dose methotrexate with thymidine and low-dose leucovorin.
    Cancer research, 1982, Volume: 42, Issue:11

    Topics: Adult; Aged; Drug Evaluation; Female; Humans; Kinetics; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Thymidine

1982
Comparison of thymidine and folinic acid protection from methotrexate toxicity in human lymphoid cell lines.
    Cancer treatment reports, 1982, Volume: 66, Issue:12

    Topics: B-Lymphocytes; Cell Division; Cell Line; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Lymphocytes; Methotrexate; T-Lymphocytes; Thymidine

1982
[Radiational basis and practice of the citrovorum factor (Leucovorin) protection after high-dose methotrexate therapy. High-dose methotrexate/leucovorin].
    Onkologie, 1980, Volume: 3, Issue:2

    Topics: Bone Marrow; Deoxyuridine; DNA; Dose-Response Relationship, Drug; Humans; Leucovorin; Lymphocytes; Methotrexate; Thymidine

1980
5-Methyltetrahydrofolate related enzymes and DNA polymerase alpha activities in bone marrow cells from patients with vitamin B12 deficient megaloblastic anemia.
    Blood, 1982, Volume: 59, Issue:4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Alcohol Oxidoreductases; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA Polymerase II; DNA-Directed DNA Polymerase; Female; Folic Acid; Humans; Hydroxocobalamin; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Tetrahydrofolates; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency

1982
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
    Journal of medicinal chemistry, 1995, Sep-15, Volume: 38, Issue:19

    Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1995
Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil.
    Biochemical pharmacology, 1995, Feb-14, Volume: 49, Issue:4

    Topics: Cell Cycle; Colonic Neoplasms; DNA; Drug Interactions; Fluorouracil; Humans; Leucovorin; S Phase; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1995
Modulation of target enzyme associated with the action of antifolates.
    Advances in enzyme regulation, 1994, Volume: 34

    Topics: Antimetabolites, Antineoplastic; Carcinoma; Dose-Response Relationship, Drug; Drug Interactions; Evaluation Studies as Topic; Humans; Intestinal Neoplasms; Leucovorin; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1994
Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid.
    British journal of cancer, 1994, Volume: 69, Issue:2

    Topics: Antineoplastic Agents; Cell Cycle; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Ovarian Neoplasms; Tetrahydrofolates; Thymidine; Time Factors; Tumor Cells, Cultured

1994
Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:5

    Topics: Adolescent; Adult; Antidotes; Antimetabolites, Antineoplastic; Carboxypeptidases; Child; Child, Preschool; Female; Humans; Infant; Kidney; Kidney Diseases; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Thymidine

1997
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
    International journal of oncology, 1999, Volume: 15, Issue:6

    Topics: Cell Cycle; Cell Division; Culture Media; Drug Resistance; Enzyme Inhibitors; Fetal Blood; Head and Neck Neoplasms; Humans; Hypoxanthine; Inhibitory Concentration 50; Leucovorin; Leukemia; Methotrexate; Quinazolines; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured

1999
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
    Cancer research, 2001, May-01, Volume: 61, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase

2001
Homocysteine metabolism in children with Down syndrome: in vitro modulation.
    American journal of human genetics, 2001, Volume: 69, Issue:1

    Topics: Adenosine; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cystathionine beta-Synthase; Cysteine; DNA Methylation; Down Syndrome; Glutathione; Homocysteine; Humans; Leucovorin; Lymphocytes; Methionine; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Superoxide Dismutase; Thymidine; Vitamin B 12

2001
Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure.
    Cancer chemotherapy and pharmacology, 2001, Volume: 47, Issue:6

    Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Brain Neoplasms; Drug Therapy, Combination; Humans; Leucovorin; Lymphoma; Methotrexate; Middle Aged; Thymidine

2001
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Sep-01, Volume: 167, Issue:5

    Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Base Sequence; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Folic Acid Antagonists; Gene Expression; Genes, Reporter; HeLa Cells; Humans; I-kappa B Kinase; I-kappa B Proteins; Jurkat Cells; Leucovorin; Methotrexate; NF-kappa B; NF-KappaB Inhibitor alpha; Oligodeoxyribonucleotides; Phosphorylation; Protein Serine-Threonine Kinases; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2B; Theobromine; Thymidine; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; U937 Cells

2001
Sparing of folinic acid by thymidine.
    Science (New York, N.Y.), 1961, Jun-02, Volume: 133, Issue:3466

    Topics: Folic Acid; Leucovorin; Nucleosides; Nucleotides; Thymidine

1961
CULTURE OF SINGLE MAMMALIAN CELLS.
    Nature, 1963, Jul-20, Volume: 199

    Topics: Animals; Cattle; Cholesterol; Corrinoids; Culture Media; Insulin; Leucovorin; Research; Research Design; Serine; Thymidine; Tissue Culture Techniques; Vitamin B 12

1963
[TOPICAL ADMINISTRATION OF CARCINOSTATIC AGENTS, WITH SPECIAL REFERENCE TO CONTINUOUS INTRA-ARTERIAL INJECTION AND TUMOR PERFUSION].
    Gan no rinsho. Japan journal of cancer clinics, 1964, Volume: 10

    Topics: Administration, Topical; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Humans; Injections, Intra-Arterial; Leucovorin; Mitomycin; Mitomycins; Neoplasms; Thymidine; Tritium

1964
Effect of thymidine, citrovorum factor, folic acid and degradation products of vitamin B12 on red blood cell counts in experimental anemia in male mice.
    Archives of biochemistry and biophysics, 1952, Volume: 36, Issue:2

    Topics: Anemia; Animals; Blood Cell Count; Erythrocytes; Folic Acid; Leucovorin; Male; Mice; Thiamine; Thymidine; Vitamin B 12

1952
The relationship of folic acid, vitamin B12 and thymidine in the nutrition of Leuconostoç citrovorum 8081.
    Archives of biochemistry, 1949, Volume: 24, Issue:1

    Topics: Bacteria; Corrinoids; Folic Acid; Humans; Leuconostoc; Leucovorin; Thymidine; Vitamin B 12

1949
[Management recommendations in patients with methotrexate intoxication].
    Nederlands tijdschrift voor geneeskunde, 2007, Feb-10, Volume: 151, Issue:6

    Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Female; Humans; Kidney; Leucovorin; Lymphoma; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Renal Insufficiency; Thymidine; Vitamin B Complex

2007
Case files of the New York City Poison Control Center: antidotal strategies for the management of methotrexate toxicity.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2008, Volume: 4, Issue:2

    Topics: Antidotes; Antimetabolites, Antineoplastic; Child; Fluid Therapy; Folic Acid; gamma-Glutamyl Hydrolase; Hemoperfusion; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; New York City; Poison Control Centers; Poisoning; Renal Dialysis; Thymidine; Treatment Outcome; Vitamin B Complex

2008
Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Sep-01, Volume: 28, Issue:25

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug Administration Schedule; Drug Therapy, Combination; Female; gamma-Glutamyl Hydrolase; Humans; Infant; Kidney Diseases; Leucovorin; Male; Methotrexate; Middle Aged; Thymidine

2010
Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.
    Journal of virology, 2013, Volume: 87, Issue:17

    Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dengue Virus; Disease Models, Animal; DNA Viruses; Flavivirus; Flavivirus Infections; Floxuridine; HEK293 Cells; HeLa Cells; Humans; Leucovorin; Methotrexate; Mice; Mice, 129 Strain; Mice, Inbred C57BL; RNA Viruses; Thymidine; Tumor Suppressor Protein p53; Vero Cells; Virus Replication; West Nile virus

2013
Serine hydroxymethyltransferase: a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae.
    Current genetics, 2015, Volume: 61, Issue:4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aminoimidazole Carboxamide; Carbon-Nitrogen Ligases; Folic Acid; Gene Expression Regulation, Fungal; Glycine Hydroxymethyltransferase; Histidine; Leucovorin; Methionine; Mutation; Purines; Ribonucleotides; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tetrahydrofolates; Thymidine; Trans-Activators; Transcriptional Activation

2015
Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018, Volume: 59, Issue:7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Artifacts; Biological Transport; Cell Transformation, Neoplastic; Colorectal Neoplasms; Dideoxynucleosides; Diffusion Magnetic Resonance Imaging; Female; Fluorouracil; HCT116 Cells; Humans; Leucovorin; Mice; Organoplatinum Compounds; Thymidine

2018