thymidine has been researched along with levoleucovorin in 98 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 78 (79.59) | 18.7374 |
1990's | 10 (10.20) | 18.2507 |
2000's | 6 (6.12) | 29.6817 |
2010's | 4 (4.08) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Roberts, D; Warmath, EV | 1 |
Heidelberger, C; Moran, RG; Mulkins, M | 1 |
Harrap, KR; Straw, JA; Talbot, DC; Taylor, GA | 1 |
Lietman, PS; Rogers, HJ | 2 |
Bertino, JR | 1 |
Browman, GP; Harrap, KR; Taylor, GA | 1 |
Shearer, M; Taylor-Papadimitriou, J; Watling, D | 1 |
Grindey, GB; Pavelic, ZP; Semon, JH | 1 |
Ganeshaguru, K; Hoffbrand, AV | 1 |
Frei, E; Howell, SB; Krishan, A | 1 |
Hannan, GN; McAuslan, BR; Reilly, W | 1 |
Neugut, AI; Weinstein, IB | 1 |
Sauer, H; Schalhorn, A; Wilmanns, W | 2 |
Friedman, MA; Sadée, W | 1 |
Frei, E | 1 |
Brown, B; Frei, E; Tattersall, MH | 1 |
Frei, E; Jaffe, N; Parker, L; Pitman, S; Tattersall, MH | 1 |
Hsie, AW; Schröder, CH | 1 |
Harrap, KR; Jackson, RC; Taylor, GA | 1 |
Brown, BL; Frei, E; Tattersall, MH | 1 |
White, PJ; Widdowson, D | 1 |
Greenberg, ML; Waxman, S | 1 |
Saunders, J; Wickramasinghe, SN; Williams, G | 1 |
Bull, JM; Chabner, BA; Pinedo, HM; Zaharko, DS | 1 |
Azizkhan, JC; Speeg, KV; Stromberg, K | 1 |
Cloos, J; Noordhuis, P; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL | 1 |
Grem, JL | 1 |
Rustum, YM; Yin, MB | 1 |
Chang, CC; Li, IC; Trosko, JE | 1 |
Booker, L; Browman, GP; Spiegl, P | 1 |
Kane, MA; Raptis, G; Roth, E; Schreiber, C; Waxman, S | 1 |
Arbuck, SG; Creaven, PJ; Herrera, L; Mittelman, A; Petrelli, N; Rustum, YM; Trave, F; Zakrzewski, SF | 1 |
Akiyama, Y; Kiriyama, Y; Kito, T; Kubota, M; Mikawa, H; Takimoto, T; Tanizawa, A | 2 |
Bertino, JR; Sobrero, AF | 1 |
Barlowe, CK; Goldman, ID; Matherly, LH; Phillips, VM | 1 |
Bertino, JR; Mini, E; Moroson, BA | 1 |
Lönn, S; Lönn, U | 1 |
Branda, RF; McCormack, JJ; Perlmutter, CA | 1 |
Burres, NS; Cass, CE | 1 |
Diddens, H; Niethammer, D; Teufel, T | 1 |
Bygbjerg, IC | 1 |
Rustum, YM | 1 |
Grunberg, E | 1 |
Canellos, GP; Greenberg, NH; Mead, JA; Schrecker, AW | 1 |
Grossowicz, N; Mandelbaum-Shavit, F | 1 |
Makulu, DR | 1 |
Myers, RF; Thirugnanam, M | 1 |
Berry, CL; Germain, J | 1 |
Cooper, LE; Groth, DP; Vogler, WR | 1 |
Carlin, SC; Friedkin, M; Rosenberg, RN; VandeVenter, L | 1 |
Bishop, A; Foerster, J; Hryniuk, WM | 1 |
McBurney, MW; Whitmore, GF | 1 |
Borsa, J; Whitmore, GF | 2 |
Bertino, JR; McCullough, JL; O'Brien, P | 1 |
Hakala, MT | 1 |
Loehr, EV; Roberts, D | 1 |
Singer, R; Weidauer, H | 1 |
Beaulieu, D; Matiaszuk, NV; Pottier, A; Rosenblatt, DS; Vuchich, MJ; Whitehead, VM | 1 |
Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ | 1 |
Kano, Y; Kubota, T; Miura, Y; Sakamoto, S; Sakuraya, K; Taguchi, H; Takaku, F | 1 |
Abelson, HT; Beardsley, GP; Fosburg, MT; Goorin, AM; Gorka, C; Link, D; Link, M | 1 |
Samuels, LL; Straw, JA | 1 |
Chu, EH; Li, IC | 1 |
Leyva, A; Nederbragt, H; Pinedo, HM; Uitendaal, MP; van der Grint, L | 1 |
Bogyo, D; Mihich, E | 1 |
Browman, GP; Calvert, AH; Harrap, KR; Hart, LI; Taylor, GA | 1 |
Evans, RM; Hakala, MT; Laskin, JD | 1 |
Ariel, M; Grossowicz, N; Holtzer, E; Lavi, H | 1 |
Chanarin, I; Deacon, R; Lumb, M; Perry, J | 1 |
Bruno, S; Creaven, P; Grindey, G; Kinahan, J; Ledesma, E; Mittelman, A; Moayeri, H; Priore, R; Zakrzewski, S | 1 |
Browman, GP | 1 |
Sauer, H; Schalhorn, A | 1 |
Hida, K; Kano, Y; Sakamoto, S; Suda, K; Takaku, F | 1 |
Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ | 1 |
Handschumacher, RE; Pizzorno, G; Sun, Z | 1 |
Cao, S; Rustum, YM; Yin, MB | 1 |
D'Incalci, M; Erba, E; Sen, S; Sessa, C; Vikhanskaya, FL | 1 |
Adamson, PC; Balis, FM; Montello, MJ; Murphy, RF; O'Brien, M; Sorensen, JM; Widemann, BC | 1 |
Canestrari, JG; McGuire, JJ; Nagel, GS | 1 |
Backus, HH; Bunni, MA; Comijn, L; Jackman, AL; Jansen, G; Mitchell, F; Peters, GJ; Priest, DG; Smid, K; van der Wilt, CL; Veerman, G; Voorn, DA; Wouters, D | 1 |
Chango, A; James, SJ; Melnyk, S; Pogribna, M; Pogribny, I; Yi, P | 1 |
Beijnen, JH; Boogerd, W; Mathĵt, RA; Schellens, JH; Schornagel, JH; Soesan, M; van den Bongard, HJ | 1 |
Aggarwal, BB; Majumdar, S | 1 |
GROSSOWICZ, N; MANDELBAUM, F | 1 |
MATSUYA, Y; YAMANE, I | 1 |
SHIRAHA, Y | 1 |
DUNN, MS; VIJAYARAGHAVAN, PK | 1 |
SAUBERLICH, HE | 1 |
Beijnen, JH; Schellens, JH | 1 |
Nelson, LS; Smith, SW | 1 |
Adamson, PC; Balis, FM; Boron, M; Cole, DE; Eby, M; Fox, E; Ivy, P; Jayaprakash, N; Kim, A; Murphy, RF; O'Brien, M; Shalabi, A; Widemann, BC | 1 |
Bhinder, B; Djaballah, H; Fischer, MA; Früh, K; Hirsch, AJ; Nelson, JA; Parkins, C; Radu, C; Shum, D; Smith, JL; Stein, DA | 1 |
Daignan-Fornier, B; Hürlimann, HC; Pinson, B; Saint-Marc, C | 1 |
Aboagye, EO; Doblas, S; Döring, C; Faber, C; Fricke, IB; Griffiths, JR; Heinzmann, K; Heller, A; Hermann, S; Honess, DJ; Jacobs, AH; Just, N; Rieder, N; Schäfers, KP; Schelhaas, S; Schneider, R; Sinkus, R; Smith, DM; Wachsmuth, L | 1 |
5 review(s) available for thymidine and levoleucovorin
Article | Year |
---|---|
The fluoropyrimidines: biochemical mechanisms and design of clinical trials.
Topics: Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Humans; Leucovorin; Metabolism; Methotrexate; Pyrimidines; Thymidine; Thymine | 1978 |
Methotrexate revisited.
Topics: Adolescent; Adult; Alkalies; Aminopterin; Animals; Bone Marrow; Bone Neoplasms; Drug Therapy, Combination; Female; Folic Acid Antagonists; Humans; Kidney; Kidney Failure, Chronic; Leucovorin; Leukemia L1210; Methotrexate; Neoplasm Metastasis; Osteosarcoma; Thymidine; Vincristine | 1976 |
Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience.
Topics: Colonic Neoplasms; Deoxyuridine; Dipyridamole; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Nucleosides; Nucleotides; RNA, Neoplasm; Thymidine; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
The effect of trimethoprim on the activity of sulfonamides and antibiotics in experimental infections.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bacterial Infections; Drug Synergism; Escherichia coli Infections; Haemophilus Infections; Klebsiella Infections; Leucovorin; Mice; Microbial Sensitivity Tests; Pneumococcal Infections; Proteus Infections; Pseudomonas aeruginosa; Pseudomonas Infections; Salmonella Infections; Staphylococcal Infections; Sulfonamides; Thymidine; Trimethoprim | 1973 |
[Results of primary antineoplastic chemotherapy in advanced keratinizing squamous epithelial carcinomas of the head and neck region].
Topics: Adult; Aged; Bleomycin; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Inosine; Leucovorin; Male; Methotrexate; Middle Aged; Prognosis; Thymidine; Vincristine | 1981 |
93 other study(ies) available for thymidine and levoleucovorin
Article | Year |
---|---|
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antagonists; Humans; Hypoxanthines; Leucovorin; Leukemia, Lymphoid; Methotrexate; Purines; Thymidine | 1975 |
Role of thymidylate synthetase activity in development of methotrexate cytotoxicity.
Topics: Animals; Cell Division; Cells, Cultured; Floxuridine; Humans; Hypoxanthines; Leucovorin; Leukemia, Experimental; Methotrexate; Methyltransferases; Mice; Thymidine; Thymidylate Synthase | 1979 |
Some observations on the reversibility of methotrexate toxicity in normal proliferating tissues.
Topics: Animals; Bone Marrow; Bone Marrow Cells; DNA; Drug Interactions; Drug Therapy, Combination; Hypoxanthines; Intestinal Mucosa; Intestines; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Purines; Pyrimidines; Thymidine | 1977 |
Effect of folate and folinate on 3H-thymidine incorporation by transforming human lymphocytes in vitro.
Topics: Concanavalin A; DNA; DNA Replication; Dose-Response Relationship, Drug; Folic Acid; Humans; Leucovorin; Lymphocyte Activation; Lymphocytes; Thymidine; Tritium | 1977 |
"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.
Topics: Animals; Asparaginase; Breast Neoplasms; Carboxypeptidases; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia; Lung Neoplasms; Lymphoma; Melanoma; Methotrexate; Neoplasms; Osteosarcoma; Tetrahydrofolates; Thymidine | 1977 |
Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines.
Topics: Allopurinol; Animals; Drug Synergism; Female; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Purines; Pyrimidines; Thymidine; Time Factors | 1977 |
The in vitro effect of trimethoprim on blastogenic transformation of human peripheral blood lymphocytes.
Topics: Autoradiography; Cells, Cultured; Concanavalin A; Deoxyuridine; Folic Acid; Formates; Humans; In Vitro Techniques; Leucine; Leucovorin; Lymphocyte Activation; Lymphocytes; Thymidine; Time Factors; Trimethoprim; Uridine | 1977 |
Growth requirements of calf lens epithelium in culture.
Topics: Animals; Blood; Cattle; Cell Division; Cell Line; Culture Media; Epithelial Cells; Fibroblasts; Folic Acid; Lens, Crystalline; Leucovorin; Methotrexate; Mice; Mitomycins; Thymidine | 1978 |
Modulation versus rescue of antimetabolite toxicity by salvage metabolites administered by continuous infusion.
Topics: Animals; Drug Therapy, Combination; Duodenal Diseases; Female; Infusions, Parenteral; Inosine; Lethal Dose 50; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Thymidine | 1978 |
The effect of deoxyuridine, vitamin B12, folate and alcohol on the uptake of thymidine and on the deoxynucleoside triphosphate concentrations in normal and megaloblastic cells.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyadenine Nucleotides; Deoxyuridine; DNA; Ethanol; Folic Acid; Humans; Leucovorin; Lymphocytes; Tetrahydrofolates; Thymidine; Thymine Nucleotides; Vitamin B 12 | 1978 |
Cytokinetic comparison of thymidine and leucovorin rescue of marrow in humans after exposure to high-dose methotrexate.
Topics: Bone Marrow; Cell Cycle; DNA, Neoplasm; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Thymidine | 1979 |
Stimulation of endothelia cell proliferation by precursors of thymidylate.
Topics: Animals; Aorta; Cattle; Cell Count; Cell Division; Cells, Cultured; Clone Cells; Cornea; Culture Media; Endothelium; Folic Acid; gamma-Glutamyl Hydrolase; Leucovorin; Serum Albumin, Bovine; Thymidine | 1979 |
Growth limitation of BHK-21 cells and its relation to folate metabolism.
Topics: Aminopterin; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Drug Resistance; Folic Acid; Hypoxanthines; Kidney; Leucovorin; Tetrahydrofolate Dehydrogenase; Thymidine | 1979 |
The biochemistry of the citrovorum factor rescue effect in normal bone marrow cells after high-dose methotrexate.
Topics: Adult; Bone Marrow; Cells, Cultured; Deoxyuridine; Humans; Leucovorin; Lymphocytes; Male; Methotrexate; Middle Aged; Osteosarcoma; Thymidine; Thymidine Kinase | 1979 |
The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects.
Topics: Allopurinol; Animals; Drug Therapy, Combination; Leucovorin; Leukemia L1210; Male; Methotrexate; Mice; Thymidine | 1975 |
New approaches to cancer chemotherapy with methotrexate.
Topics: Adult; Animals; Biological Transport; Bone Marrow; Creatinine; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Kidney; Leucovorin; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Purines; Thymidine; Thymine Nucleotides | 1975 |
A temperature-sensitive auxotropic variant of Chinese hamster ovary cells.
Topics: Animals; Bromodeoxyuridine; Cell Line; Clone Cells; Cricetinae; Female; Glycine; Hypoxanthines; Leucovorin; Molecular Biology; Ovary; Temperature; Tetrahydrofolate Dehydrogenase; Thymidine; Uridine | 1975 |
Aspects of the biochemical pharmacology of cytembena.
Topics: Acrylates; Animals; Cell Division; DNA Nucleotidyltransferases; DNA, Neoplasm; Dose-Response Relationship, Drug; Folic Acid; Formate-Tetrahydrofolate Ligase; Glycine Hydroxymethyltransferase; Humans; In Vitro Techniques; Leucine; Leucovorin; Leukemia L1210; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Rats; Sarcoma, Yoshida; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidine; Thymidine Kinase; Thymidylate Synthase; Uridine | 1975 |
Methotrexate-thymidine treatment of murine leukemia.
Topics: Allopurinol; Animals; Drug Evaluation, Preclinical; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidine | 1975 |
The nutritional requirements of methicillin-dependent and -resistant strains of Pediococcus cerevisiae.
Topics: Acetates; Alanine; Amino Acids; Culture Media; Glucose; Lactates; Leucovorin; Methicillin; Mutation; Pantothenic Acid; Pediococcus; Penicillin Resistance; Penicillins; Species Specificity; Thioglycolates; Thymidine | 1976 |
Sequential use of methotrexate, folinic acid, and cytosine arabinoside in the treatment of acute leukemia.
Topics: Adult; Bone Marrow; Bone Marrow Cells; Child; Cytarabine; Deoxyuridine; DNA; Drug Administration Schedule; Female; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mitosis; Thymidine; Thymine | 1976 |
Effects of anticonvulsant drugs on the synthesis of DNA and protein by human bone marrow cells in vitro.
Topics: Bone Marrow; Bone Marrow Cells; DNA; Folic Acid; Humans; Leucine; Leucovorin; Phenobarbital; Phenytoin; Protein Biosynthesis; Thymidine | 1976 |
The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides.
Topics: Adenosine; Animals; Cell Division; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Granulocytes; Guanosine; Hematopoietic Stem Cells; Inosine; Leucovorin; Leukocytes; Male; Methotrexate; Mice; Mice, Inbred C57BL; Ribonucleosides; Thymidine | 1976 |
The stimulation by methotrexate of human chorionic gonadotropin and placental alkaline phosphatase in cultured choriocarcinoma cells.
Topics: Alkaline Phosphatase; Cells, Cultured; Choriocarcinoma; Chorionic Gonadotropin; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Induction; Female; Humans; L-Lactate Dehydrogenase; Leucovorin; Methotrexate; Neoplasm Proteins; Placenta; Pregnancy; RNA, Neoplasm; Thymidine; Uterine Neoplasms | 1976 |
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Topics: Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovorin; Mice; Mice, Inbred BALB C; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition.
Topics: Adenocarcinoma; Cell Division; Colonic Neoplasms; DNA; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Leucovorin; Thymidine; Time Factors | 1991 |
Thymidylate synthetase gene as a quantitative mutation marker in Chinese hamster cells.
Topics: Animals; Cells, Cultured; Culture Media; Ethyl Methanesulfonate; Gene Expression; Genetic Markers; Hypoxanthine; Hypoxanthines; Leucovorin; Mutation; Thymidine; Thymidylate Synthase; Time Factors; Ultraviolet Rays | 1990 |
Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate.
Topics: Cell Division; Cell Line; Drug Antagonism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Lymphoid Tissue; Methotrexate; Polyglutamic Acid; Tetrahydrofolates; Thymidine; Uridine | 1985 |
Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Survival; Fluorouracil; Folic Acid; Glucose; Humans; KB Cells; Leucovorin; Leukemia, Myeloid, Acute; Methotrexate; Nasopharyngeal Neoplasms; Pentosephosphates; Phosphoribosyl Pyrophosphate; Thymidine | 1987 |
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia L1210; Mice; RNA; Stomach Neoplasms; Thymidine; Thymidylate Synthase | 1987 |
Synergistic effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
Topics: Aphidicolin; Cell Line; Cytarabine; Diterpenes; DNA Damage; Drug Combinations; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Phosphorylation; Thymidine | 1989 |
Sequential combination of methotrexate and 1-beta-D-arabinofuranosylcytosine shows synergistic effect on the generation of DNA strand breaks in a human promyelocytic leukemia cell line.
Topics: Arabinofuranosylcytosine Triphosphate; Cycloheximide; Cytarabine; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Leukemia, Promyelocytic, Acute; Methotrexate; Thymidine; Tumor Cells, Cultured | 1989 |
Endogenous thymidine and hypoxanthine are a source of error in evaluating methotrexate cytotoxicity by clonogenic assays using undialyzed fetal bovine serum.
Topics: Adenocarcinoma; Animals; Cattle; Cell Adhesion; Colonic Neoplasms; Colony-Forming Units Assay; Culture Media; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Methotrexate; Neoplastic Stem Cells; Quinazolines; Thymidine; Trimetrexate | 1986 |
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
Topics: Adenosine; Animals; Cell Division; Floxuridine; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mice; Thymidine | 1987 |
Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin.
Topics: Cell Division; Cell Line; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Leukemia, Lymphoid; T-Lymphocytes; Thymidine | 1987 |
Increased levels of DNA lesions induced by leucovorin-5-fluoropyrimidine in human colon adenocarcinoma.
Topics: Adenocarcinoma; Aphidicolin; Cell Line; Cell Survival; Colonic Neoplasms; Diterpenes; DNA; DNA Damage; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Pyrimidines; Thymidine | 1988 |
Cellular pharmacology of chloroquinoxaline sulfonamide and a related compound in murine B16 melanoma cells.
Topics: Animals; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Deoxyuridine; DNA; Flow Cytometry; Leucovorin; Melanoma; Mice; Quinoxalines; Sulfanilamides; Sulfaquinoxaline; Tetrahydrofolate Dehydrogenase; Thymidine | 1988 |
Inhibition of methotrexate-induced differentiation of cultured human choriocarcinoma (BeWo) cells by thymidine.
Topics: Cell Differentiation; Cells, Cultured; Choriocarcinoma; DNA; DNA Replication; Female; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Methotrexate; Pregnancy; Thymidine; Uterine Neoplasms | 1987 |
High-dose methotrexate therapy with leucovorin rescue: in vitro investigations on human osteosarcoma cell lines.
Topics: Cell Line; Cell Survival; Deoxyuridine; DNA, Neoplasm; Humans; Leucovorin; Methotrexate; Osteosarcoma; Thymidine; Tumor Cells, Cultured | 1987 |
Effect of proguanil and cycloguanil on human lymphocytes in vitro.
Topics: Humans; Leucovorin; Lymphocyte Activation; Proguanil; Thymidine; Triazines | 1985 |
Selective modulation of 5-fluorouracil action in patients with colorectal carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Kinetics; Leucovorin; Mice; Mice, Inbred BALB C; Rats; Rectal Neoplasms; Thymidine | 1985 |
The effect of treatment with cytotoxic agents on mouse spleen dihydrofolate reductase activity.
Topics: Animals; Cyclophosphamide; Floxuridine; Folic Acid; In Vitro Techniques; Leucovorin; Male; Methotrexate; Mice; Nucleosides; Organ Size; Spleen; Tetrahydrofolate Dehydrogenase; Thymidine | 1967 |
Effect of folinate on thymidine uptake by Pediococcus cerevisiae.
Topics: Aminopterin; Carbon Isotopes; Deoxyuridine; Floxuridine; Glucose; Hydrogen-Ion Concentration; Iodoacetates; Leucovorin; Methotrexate; Pediococcus; Temperature; Thymidine; Thymine; Tritium; Uracil | 1968 |
Mode of action of methotrexate upon insulin-antibody formation in guinea pigs.
Topics: Adenosine; Animals; Antibody Formation; Deoxyadenosines; Depression, Chemical; Drug Antagonism; Floxuridine; Formates; Guanosine; Guinea Pigs; Immunization; Immunosuppressive Agents; Insulin Antibodies; Iodine Isotopes; Leucovorin; Male; Mathematics; Methotrexate; Swine; Tetrahydrofolates; Thymidine; Time Factors | 1972 |
Nutrient media for plant-parasitic nematodes. VI. Nucleic acids content and nucleotide synthesis in Aphelenchoides rutgersi.
Topics: Adenosine Monophosphate; Animals; Carbon Radioisotopes; Culture Media; Cytidine Monophosphate; DNA; Folic Acid Antagonists; Glucose; Glycine; Guanosine Monophosphate; Inosine; Leucovorin; Lipids; Methods; Nematoda; Nucleotides; Orotic Acid; Protein Biosynthesis; RNA; Thymidine; Tritium; Uridine Monophosphate | 1974 |
Absence of the third molar tooth in the mouse: its relevance to human malformation.
Topics: Animals; Anodontia; Deficiency Diseases; DNA; Female; Humans; Injections, Intraperitoneal; Leucovorin; Liver; Methotrexate; Mice; Mice, Inbred CBA; Molar; Thymidine; Tooth Abnormalities; Tritium | 1972 |
Correlation of cytosine arabinoside-induced increment in growth fraction of leukemic blast cells with clinical response.
Topics: Adult; Aged; Bone Marrow; Bone Marrow Cells; Cell Division; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Female; Humans; Leucovorin; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mitosis; Thymidine; Time Factors; Tritium | 1974 |
Quinazoline antifolates as inhibitors of growth, dihydrofolate reductase, and thymidylate synthetase of mouse neuroblastoma cells in culture.
Topics: Animals; Cells, Cultured; Chromatography, Paper; Folic Acid Antagonists; Growth; Kinetics; Leucovorin; Methyltransferases; Mice; Neoplasms, Experimental; Neuroblastoma; Quinazolines; Thymidine; Thymidylate Synthase | 1974 |
Clinical correlates of in vitro effect of methotrexate on acute leukemia blasts.
Topics: Adolescent; Adult; Bone Marrow; Bone Marrow Cells; Cell Biology; Cell Survival; Child; DNA, Neoplasm; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocytes; Methotrexate; Purines; Remission, Spontaneous; Thymidine; Tritium | 1974 |
Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells.
Topics: Adenosine; Animals; Cell Fusion; Cell Survival; Cells, Cultured; Chromatography, DEAE-Cellulose; Clone Cells; Cricetinae; Crosses, Genetic; Culture Media; DNA; Female; Folic Acid; Glycine; Hybrid Cells; Leucovorin; Methotrexate; Mutation; Ovary; Phenotype; RNA; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1974 |
Studies relating to the mode of action of methotrexate. 3. Inhibition of thymidylate synthetase in tissue culture cells and in cell-free systems.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Culture Techniques; Deoxyuridine; DNA; Embryo, Mammalian; Escherichia coli; Folic Acid; Histocytochemistry; Kinetics; L Cells; Leucovorin; Methotrexate; Mice; Nucleotides; RNA; Thymidine; Transferases; Tritium | 1969 |
Studies relating to the mode of action of methotrexate. II. Studies on sites of action in L-cells in vitro.
Topics: Animals; Cattle; Culture Media; Culture Techniques; L Cells; Leucovorin; Methotrexate; Nucleosides; Nucleotides; Purines; Tetrahydrofolate Dehydrogenase; Thymidine | 1969 |
Inhibition of growth of leukemia cells by enzymic folate depletion.
Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; Folic Acid; Humans; Hypoxanthines; In Vitro Techniques; Leucovorin; Leukemia L1210; Leukemia, Experimental; Methotrexate; Pseudomonas; Serine; Thymidine | 1971 |
Homofolate and tetrahydrohomofolate, inhibitors of purine synthesis.
Topics: Animals; Culture Media; Culture Techniques; Folic Acid; Glycine; Leucovorin; Methotrexate; Neoplasms, Experimental; Purines; Sarcoma, Experimental; Thymidine | 1971 |
Elevation of thymidylate synthetase activity in CCRF-CEM cells.
Topics: Cell Line; Cells, Cultured; Child; Deoxyuridine; Humans; In Vitro Techniques; Leucovorin; Leukemia, Lymphoid; Methotrexate; Methyltransferases; Thymidine; Uracil Nucleotides | 1971 |
Differential effects of folinic acid and glycine, adenosine, and thymidine as rescue agents in methotrexate-treated human cells in relation to the accumulation of methotrexate polyglutamates.
Topics: Adenosine; Deoxyuridine; DNA; Fibroblasts; Glycine; Humans; Leucovorin; Methotrexate; Polyglutamic Acid; Thymidine; Time Factors | 1982 |
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate | 1984 |
Effects of leucovorin and methylcobalamin with N2O anesthesia.
Topics: Bone Marrow; Deoxyuridine; DNA; Folic Acid; Humans; Leucovorin; Nitrous Oxide; Thymidine; Time Factors; Vitamin B 12 | 1984 |
Methotrexate-induced renal impairment: clinical studies and rescue from systemic toxicity with high-dose leucovorin and thymidine.
Topics: Adolescent; Adult; Child; Creatinine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Inulin; Kidney Diseases; Kinetics; Leucovorin; Methotrexate; Neoplasms; Thymidine | 1983 |
Improved therapeutic index with high-dose methotrexate: comparison of thymidine-purine rescue with citrovorum factor rescue in mice.
Topics: Animals; Brain Neoplasms; Deoxycytidine; DNA Replication; Dose-Response Relationship, Drug; Hypoxanthine; Hypoxanthines; Inosine; Leucovorin; Leukemia L1210; Methotrexate; Mice; Thymidine; Thymine | 1984 |
Mutants of Chinese hamster cells deficient in thymidylate synthetase.
Topics: Aminopterin; Animals; Cell Line; Cricetinae; Cricetulus; Culture Media; Drug Resistance; Leucovorin; Lung; Methyltransferases; Mutation; Thymidine; Thymidylate Synthase | 1984 |
Biochemical control of high-dose methotrexate/Leucovorin rescue therapy.
Topics: Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Humans; Leucovorin; Methotrexate; Neoplasms; Thymidine; Thymidine Kinase | 1980 |
Reversal of methotrexate inhibition of colony growth of L1210 leukemia cells in semisolid medium.
Topics: Animals; Bone Marrow; Cell Division; Clone Cells; Culture Media; Inosine; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Thymidine | 1981 |
Reversal of the in vitro methotrexate suppression of cell-mediated immune response by folinic acid and thymidine plus hypoxanthine.
Topics: Animals; Cells, Cultured; Drug Interactions; Hypoxanthines; Immune Tolerance; Immunity, Cellular; Leucovorin; Methotrexate; Mice; Thymidine; Time Factors | 1980 |
The intracellular mechanism of action of metoprine (DDMP).
Topics: Animals; Cell Survival; Cells, Cultured; Deoxyuridine; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimethamine; Pyrimidines; Thymidine | 1980 |
Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.
Topics: Animals; Carcinoma; Cell Line; Deoxyribonucleosides; Deoxyribose; Deoxyuridine; Drug Synergism; Fluorouracil; Humans; Inosine; Leucovorin; Mice; Sarcoma, Experimental; Thymidine; Thymidylate Synthase | 1981 |
Physiological and enzymatic properties of a thymidine-requiring Pediococcus cerevisiae mutant.
Topics: Aminopterin; Folic Acid; Leucovorin; Methotrexate; Methyltransferases; Mutation; Pediococcus; Tetrahydrofolate Dehydrogenase; Thymidine; Thymidylate Synthase | 1982 |
A comparison of tetrahydrofolate and 5-formyltetrahydrofolate in correcting the impairment of thymidine synthesis in pernicious anaemia.
Topics: Anemia, Pernicious; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Leucovorin; Tetrahydrofolates; Thymidine | 1982 |
Phase I study of high-dose methotrexate with thymidine and low-dose leucovorin.
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Kinetics; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Thymidine | 1982 |
Comparison of thymidine and folinic acid protection from methotrexate toxicity in human lymphoid cell lines.
Topics: B-Lymphocytes; Cell Division; Cell Line; Dose-Response Relationship, Drug; Humans; Hypoxanthines; Leucovorin; Lymphocytes; Methotrexate; T-Lymphocytes; Thymidine | 1982 |
[Radiational basis and practice of the citrovorum factor (Leucovorin) protection after high-dose methotrexate therapy. High-dose methotrexate/leucovorin].
Topics: Bone Marrow; Deoxyuridine; DNA; Dose-Response Relationship, Drug; Humans; Leucovorin; Lymphocytes; Methotrexate; Thymidine | 1980 |
5-Methyltetrahydrofolate related enzymes and DNA polymerase alpha activities in bone marrow cells from patients with vitamin B12 deficient megaloblastic anemia.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Alcohol Oxidoreductases; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA Polymerase II; DNA-Directed DNA Polymerase; Female; Folic Acid; Humans; Hydroxocobalamin; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Tetrahydrofolates; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1982 |
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil.
Topics: Cell Cycle; Colonic Neoplasms; DNA; Drug Interactions; Fluorouracil; Humans; Leucovorin; S Phase; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Modulation of target enzyme associated with the action of antifolates.
Topics: Antimetabolites, Antineoplastic; Carcinoma; Dose-Response Relationship, Drug; Drug Interactions; Evaluation Studies as Topic; Humans; Intestinal Neoplasms; Leucovorin; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid.
Topics: Antineoplastic Agents; Cell Cycle; DNA, Neoplasm; Drug Screening Assays, Antitumor; Female; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Ovarian Neoplasms; Tetrahydrofolates; Thymidine; Time Factors; Tumor Cells, Cultured | 1994 |
Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
Topics: Adolescent; Adult; Antidotes; Antimetabolites, Antineoplastic; Carboxypeptidases; Child; Child, Preschool; Female; Humans; Infant; Kidney; Kidney Diseases; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Thymidine | 1997 |
Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.
Topics: Cell Cycle; Cell Division; Culture Media; Drug Resistance; Enzyme Inhibitors; Fetal Blood; Head and Neck Neoplasms; Humans; Hypoxanthine; Inhibitory Concentration 50; Leucovorin; Leukemia; Methotrexate; Quinazolines; Thymidine; Thymidine Phosphorylase; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pemetrexed; Quinazolines; Thiophenes; Thymidine; Thymidine Kinase; Thymidylate Synthase | 2001 |
Homocysteine metabolism in children with Down syndrome: in vitro modulation.
Topics: Adenosine; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cystathionine beta-Synthase; Cysteine; DNA Methylation; Down Syndrome; Glutathione; Homocysteine; Humans; Leucovorin; Lymphocytes; Methionine; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Sarcosine; Superoxide Dismutase; Thymidine; Vitamin B 12 | 2001 |
Successful rescue with leucovorin and thymidine in a patient with high-dose methotrexate induced acute renal failure.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Brain Neoplasms; Drug Therapy, Combination; Humans; Leucovorin; Lymphoma; Methotrexate; Middle Aged; Thymidine | 2001 |
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Base Sequence; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Folic Acid Antagonists; Gene Expression; Genes, Reporter; HeLa Cells; Humans; I-kappa B Kinase; I-kappa B Proteins; Jurkat Cells; Leucovorin; Methotrexate; NF-kappa B; NF-KappaB Inhibitor alpha; Oligodeoxyribonucleotides; Phosphorylation; Protein Serine-Threonine Kinases; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2B; Theobromine; Thymidine; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; U937 Cells | 2001 |
Sparing of folinic acid by thymidine.
Topics: Folic Acid; Leucovorin; Nucleosides; Nucleotides; Thymidine | 1961 |
CULTURE OF SINGLE MAMMALIAN CELLS.
Topics: Animals; Cattle; Cholesterol; Corrinoids; Culture Media; Insulin; Leucovorin; Research; Research Design; Serine; Thymidine; Tissue Culture Techniques; Vitamin B 12 | 1963 |
[TOPICAL ADMINISTRATION OF CARCINOSTATIC AGENTS, WITH SPECIAL REFERENCE TO CONTINUOUS INTRA-ARTERIAL INJECTION AND TUMOR PERFUSION].
Topics: Administration, Topical; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Humans; Injections, Intra-Arterial; Leucovorin; Mitomycin; Mitomycins; Neoplasms; Thymidine; Tritium | 1964 |
Effect of thymidine, citrovorum factor, folic acid and degradation products of vitamin B12 on red blood cell counts in experimental anemia in male mice.
Topics: Anemia; Animals; Blood Cell Count; Erythrocytes; Folic Acid; Leucovorin; Male; Mice; Thiamine; Thymidine; Vitamin B 12 | 1952 |
The relationship of folic acid, vitamin B12 and thymidine in the nutrition of Leuconostoç citrovorum 8081.
Topics: Bacteria; Corrinoids; Folic Acid; Humans; Leuconostoc; Leucovorin; Thymidine; Vitamin B 12 | 1949 |
[Management recommendations in patients with methotrexate intoxication].
Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Female; Humans; Kidney; Leucovorin; Lymphoma; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Renal Insufficiency; Thymidine; Vitamin B Complex | 2007 |
Case files of the New York City Poison Control Center: antidotal strategies for the management of methotrexate toxicity.
Topics: Antidotes; Antimetabolites, Antineoplastic; Child; Fluid Therapy; Folic Acid; gamma-Glutamyl Hydrolase; Hemoperfusion; Humans; Infusions, Intravenous; Leucovorin; Male; Methotrexate; New York City; Poison Control Centers; Poisoning; Renal Dialysis; Thymidine; Treatment Outcome; Vitamin B Complex | 2008 |
Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug Administration Schedule; Drug Therapy, Combination; Female; gamma-Glutamyl Hydrolase; Humans; Infant; Kidney Diseases; Leucovorin; Male; Methotrexate; Middle Aged; Thymidine | 2010 |
Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dengue Virus; Disease Models, Animal; DNA Viruses; Flavivirus; Flavivirus Infections; Floxuridine; HEK293 Cells; HeLa Cells; Humans; Leucovorin; Methotrexate; Mice; Mice, 129 Strain; Mice, Inbred C57BL; RNA Viruses; Thymidine; Tumor Suppressor Protein p53; Vero Cells; Virus Replication; West Nile virus | 2013 |
Serine hydroxymethyltransferase: a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aminoimidazole Carboxamide; Carbon-Nitrogen Ligases; Folic Acid; Gene Expression Regulation, Fungal; Glycine Hydroxymethyltransferase; Histidine; Leucovorin; Methionine; Mutation; Purines; Ribonucleotides; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tetrahydrofolates; Thymidine; Trans-Activators; Transcriptional Activation | 2015 |
Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Artifacts; Biological Transport; Cell Transformation, Neoplastic; Colorectal Neoplasms; Dideoxynucleosides; Diffusion Magnetic Resonance Imaging; Female; Fluorouracil; HCT116 Cells; Humans; Leucovorin; Mice; Organoplatinum Compounds; Thymidine | 2018 |